Compounds > hydroxyurea

hydroxyurea and sirolimus

hydroxyurea has been researched along with sirolimus in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (21.05)18.2507
2000's2 (10.53)29.6817
2010's11 (57.89)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dumont, FJ; Fischer, P; Sirotina, A1
Fabbro, D; Ferrari, S; Frost, V; Mercep, L; Meyer, T; Morley, SJ1
Buchkovich, KJ; Greider, CW1
Branellec, D; Le Roux, A; Perlman, H; Sata, M; Sedlak, TW; Walsh, K1
Ansari, AA; Bostik, P; Greenberg, KP; Mayne, AE; Powell, JD; Villinger, F1
Boehm, A; Herndlhofer, S; Jaeger, U; Knoebl, P; Mayerhofer, M; Sillaber, C; Sperr, WR; Valent, P1
Jarosz, DF; Lindquist, S1
Duan, Y; Feng, J; Jiang, L; Zhao, Y1
Ann, DK; Chen, L; Chen, W; Chen, YR; Hu, S; Kuo, ML; Tang, M; Yang, L; Yen, Y; Zhang, K; Zhang, L; Zhou, B1
Calzolari, R; Di Marzo, R; Maggio, A; Martorana, A; Pecoraro, A; Rigano, P; Sacco, M; Scazzone, C; Troia, A1
Fujimuro, M; Ito, A; Nakagawa, K; Nakata, S; Takeda, H; Watanabe, T1
Borgmann, K; Koalick, D; Ludwig, K; Pai, GM; Pospiech, H; Rubio, I; Wang, ZQ; Zielinski, A1
Al-Khatti, AA; Alkhunaizi, AM1
Barré, B; González, A; Hall, MN; Li, J; Liti, G; Long, A; Mustonen, V; Persson, K; Vázquez-García, I; Warringer, J; Yue, JX1
Cui, W; Hull, L; Li, X; Xiao, M1
Chaudhury, I; Holz, MK; Knudson, K; Nolan, M1
Li, J; Liti, G; Mikhalev, E; Stenberg, S; Thompson, D; Warringer, J; Yue, JX1

Reviews

1 review(s) available for hydroxyurea and sirolimus

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for hydroxyurea and sirolimus

ArticleYear
Evaluation of in vivo antineoplastic effects of rapamycin in patients with chemotherapy-refractory AML.
    European journal of internal medicine, 2009, Volume: 20, Issue:8

    Topics: Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Middle Aged; Pilot Projects; Sirolimus; Treatment Outcome

2009

Other Studies

17 other study(ies) available for hydroxyurea and sirolimus

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Increased LFA-1-mediated homotypic cell adhesion is associated with the G1 growth arrest induced by rapamycin in a T cell lymphoma.
    Experimental cell research, 1995, Volume: 219, Issue:1

    Topics: Animals; Antibodies; CD11 Antigens; CD18 Antigens; Cell Adhesion; Cell Cycle; Cell Division; Cell Line; Culture Media, Serum-Free; Flow Cytometry; G1 Phase; Hydroxyurea; Immunosuppressive Agents; Lymphocyte Function-Associated Antigen-1; Lymphoma, T-Cell; Mimosine; Nocodazole; Polyenes; Sirolimus; Tacrolimus; Tumor Cells, Cultured

1995
The phosphodiesterase inhibitor SQ 20006 selectively blocks mitogen activation of p70S6k and transition to S phase of the cell division cycle without affecting the steady state phosphorylation of eIF-4E.
    The Journal of biological chemistry, 1995, Nov-03, Volume: 270, Issue:44

    Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Line; Cyclic AMP; Emetine; Enzyme Activation; Eukaryotic Initiation Factor-4E; Humans; Hydroxyurea; Immunosuppressive Agents; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogens; Nicotinic Acids; Peptide Initiation Factors; Phosphodiesterase Inhibitors; Phosphorylation; Polyenes; Polyribosomes; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Reticulocytes; Ribosomal Protein S6 Kinases; S Phase; Sirolimus

1995
Telomerase regulation during entry into the cell cycle in normal human T cells.
    Molecular biology of the cell, 1996, Volume: 7, Issue:9

    Topics: Antibodies; Antigens, CD20; B-Lymphocytes; Blotting, Northern; CD2 Antigens; CD28 Antigens; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Humans; Hydroxyurea; Immunosuppressive Agents; Interleukin-2; Leukocytes; Microtubule-Associated Proteins; Phytohemagglutinins; Polyenes; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Receptor-CD3 Complex, Antigen, T-Cell; RNA; Sirolimus; T-Lymphocytes; Telomerase; Tumor Suppressor Proteins; Up-Regulation

1996
Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity.
    The EMBO journal, 1998, Jul-01, Volume: 17, Issue:13

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; G1 Phase; Homeodomain Proteins; Hydroxyurea; Male; Mice; Mitogens; Muscle Proteins; Muscle, Smooth, Vascular; Phenotype; Polyenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; S Phase; Serum Albumin, Bovine; Sirolimus; Tumor Suppressor Protein p53

1998
Relative resistance in the development of T cell anergy in CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Jan-01, Volume: 166, Issue:1

    Topics: Adult; Animals; Base Sequence; CD4-Positive T-Lymphocytes; Cells, Cultured; Cercocebus atys; Clonal Anergy; Cyclosporine; Cytokines; Epitopes, T-Lymphocyte; Humans; Hydroxyurea; Immunity, Innate; Kinetics; Lymphocyte Activation; Macaca mulatta; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muromonab-CD3; Simian Acquired Immunodeficiency Syndrome; Sirolimus

2001
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
    Science (New York, N.Y.), 2010, Dec-24, Volume: 330, Issue:6012

    Topics: Adaptation, Physiological; Biological Evolution; Crosses, Genetic; Deoxycholic Acid; Drug Resistance, Fungal; Genetic Variation; HSP90 Heat-Shock Proteins; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; Mitochondrial Proteins; Open Reading Frames; Polymorphism, Genetic; Protein Serine-Threonine Kinases; Quantitative Trait Loci; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Stress, Physiological; Sulfurtransferases

2010
Genetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and rapamycin in Candida albicans.
    FEMS yeast research, 2013, Volume: 13, Issue:1

    Topics: Antifungal Agents; Candida albicans; Cloning, Molecular; DNA Damage; DNA, Fungal; Epistasis, Genetic; Fungal Proteins; Gene Deletion; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Phenotype; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2C; Protein Serine-Threonine Kinases; Signal Transduction; Sirolimus

2013
Reciprocal regulation of autophagy and dNTP pools in human cancer cells.
    Autophagy, 2014, Volume: 10, Issue:7

    Topics: Animals; Autophagy; Gene Knockdown Techniques; Humans; Hydroxyurea; Intracellular Space; Mice, Inbred NOD; Mice, SCID; Neoplasms; Nucleotides; Ribonucleoside Diphosphate Reductase; RNA, Small Interfering; Signal Transduction; Sirolimus; Xenograft Model Antitumor Assays

2014
Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and β-Thalassemia Patients.
    Hemoglobin, 2015, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Aged; alpha-Globins; Anemia, Sickle Cell; beta-Globins; beta-Thalassemia; Cells, Cultured; Erythroid Precursor Cells; Female; Fetal Hemoglobin; gamma-Globins; Gene Expression Regulation; Genotype; Humans; Hydroxyurea; Male; Middle Aged; Mutation; Sirolimus; Young Adult

2015
The dynamics of histone H2A ubiquitination in HeLa cells exposed to rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage.
    Biochemical and biophysical research communications, 2016, Mar-25, Volume: 472, Issue:1

    Topics: Acetylation; DNA Damage; Endoplasmic Reticulum Stress; Ethanol; Heat-Shock Response; HeLa Cells; Histones; Humans; Hydrogen Peroxide; Hydroxyurea; Methyl Methanesulfonate; Sirolimus; Subcellular Fractions; Ubiquitinated Proteins; Ubiquitination

2016
TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress.
    Oncotarget, 2016, Dec-20, Volume: 7, Issue:51

    Topics: Animals; Cell Cycle; Cell Death; Cells, Cultured; Chromosome Aberrations; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Doxorubicin; Fibroblasts; Genomic Instability; Hydroxyurea; Mice, Knockout; RNA Interference; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2016
Additive effect of sirolimus and hydroxycarbamide on fetal haemoglobin level in kidney transplant patients with sickle cell disease.
    British journal of haematology, 2019, Volume: 185, Issue:5

    Topics: Adult; Anemia, Sickle Cell; Female; Fetal Hemoglobin; Humans; Hydroxyurea; Kidney Transplantation; Male; Middle Aged; Sirolimus

2019
Shared Molecular Targets Confer Resistance over Short and Long Evolutionary Timescales.
    Molecular biology and evolution, 2019, 04-01, Volume: 36, Issue:4

    Topics: Biological Evolution; Cell Cycle Proteins; Drug Resistance, Fungal; Hydroxyurea; Mutation; Phosphatidylinositol 3-Kinases; Quantitative Trait Loci; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Selection, Genetic; Sirolimus

2019
GATA-type transcription factors play a vital role in radiation sensitivity of Cryptococcus neoformans by regulating the gene expression of specific amino acid permeases.
    Scientific reports, 2019, 04-23, Volume: 9, Issue:1

    Topics: Amino Acid Transport Systems; Cryptococcus neoformans; Fluconazole; Fungal Proteins; GATA Transcription Factors; Gene Expression Regulation, Fungal; Gene Library; Hydroxyurea; Mutation; Phylogeny; Radiation Tolerance; Sirolimus

2019
Fanconi anemia and mTOR pathways functionally interact during stalled replication fork recovery.
    FEBS letters, 2021, Volume: 595, Issue:5

    Topics: Aphidicolin; Cell Survival; DNA; DNA Repair; DNA Replication; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Fibroblasts; Genome, Human; Genomic Instability; Humans; Hydroxyurea; Mitomycin; Primary Cell Culture; Protein Binding; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2021
Genome instability footprint under rapamycin and hydroxyurea treatments.
    PLoS genetics, 2023, Volume: 19, Issue:11

    Topics: DNA, Ribosomal; Genomic Instability; Humans; Hydroxyurea; Mutation; Saccharomyces cerevisiae; Sirolimus

2023