hydroxyurea and naproxen

hydroxyurea has been researched along with naproxen in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's7 (35.00)18.2507
2000's2 (10.00)29.6817
2010's9 (45.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Tausch, G1
Kazmi, SM; Lau, CY; Plante, RK; Taylor, GR; Visconti, V; Zhou, L1
Colombo, C; DiPasquale, G; Fryer, LR; Greenspan, PD; Haston, W; Healy, C; Kotyuk, B; Pastor, G; Pellas, TC; Raychaudhuri, A1
Chourmouzis, E; Fung-Leung, WP; Lau, CY; Pope, BL; Zhou, L1
Medvedeff, ED; Nickerson-Nutter, CL1
Awni, WM; Braeckman, RA; Cavanaugh, JH; Dubé, LM; Granneman, GR; Linnen, PJ; Locke, CS1
Bopp, BA; Kukulka, MJ; Machinist, JM1
Bell, RL; Bouska, J; Brooks, CD; Carter, GW; Dellaria, JF; Hulkower, KI; Kolasa, T; Rodriques, KE; Summers, JB1
Borey, AJ; Clark, JD; Cui, J; Donahue, F; Han, L; Hassan-Zahraee, M; Leach, MW; Lee, KL; Marusic, S; McKew, JC; Pelker, JW; Shen, MW; Shimizu, T; Stedman, NL; Thakker, P; Wolf, SF; Xu, X1
Horn, TL; Johnson, WD; Lubet, RA; McCormick, DL; Phillips, JM; Steele, VE1

Reviews

1 review(s) available for hydroxyurea and naproxen

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for hydroxyurea and naproxen

ArticleYear
The pharmacokinetic and pharmacodynamic interactions between the 5-lipoxygenase inhibitor zileuton and the cyclo-oxygenase inhibitor naproxen in human volunteers.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Endoscopy; Humans; Hydroxyurea; Intestinal Mucosa; Leukotriene B4; Lipoxygenase Inhibitors; Male; Naproxen; Thromboxane B2

1995

Other Studies

18 other study(ies) available for hydroxyurea and naproxen

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
[Effect of naproxen on DNA synthesis and DNA repair of human lymphocytes in in vivo experiments].
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:2A

    Topics: Arthritis, Rheumatoid; Chronic Disease; Cobalt Radioisotopes; DNA; DNA Repair; Humans; Hydroxyurea; Lymphocytes; Middle Aged; Naphthaleneacetic Acids; Naproxen; Prednisolone; Radiation Effects; Thymidine; Tritium

1975
Suppression of NF kappa B activation and NF kappa B-dependent gene expression by tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase.
    Journal of cellular biochemistry, 1995, Volume: 57, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cell Line; Chloramphenicol O-Acetyltransferase; Cyclooxygenase Inhibitors; DNA Primers; Gene Expression; HeLa Cells; Humans; Hydroxyurea; Interleukin-6; Ionomycin; Kinetics; Lipoxygenase Inhibitors; Mice; Molecular Sequence Data; Naproxen; NF-kappa B; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Proto-Oncogene Proteins c-myc; Pyrazoles; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured

1995
LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists.
    Journal of pharmacological and toxicological methods, 1993, Volume: 30, Issue:3

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dexamethasone; Hydroxyurea; Indomethacin; Leukocyte Count; Leukotriene B4; Male; Models, Biological; Naproxen; Neutropenia; Neutrophils; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene B4

1993
Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.
    European journal of immunology, 1996, Volume: 26, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Base Sequence; Binding, Competitive; Cell Movement; E-Selectin; Hydroxyurea; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Naproxen; Neutrophils; Pyrazoles; Skin; Tumor Necrosis Factor-alpha

1996
The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation.
    Arthritis and rheumatism, 1996, Volume: 39, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disease; Disease Models, Animal; Drug Combinations; Exudates and Transudates; Female; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Naproxen; Prostaglandin-Endoperoxide Synthases; Quinolines; Time Factors; Zymosan

1996
In vitro plasma protein binding of zileuton and its N-dehydroxylated metabolite.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Adult; Anti-Allergic Agents; Anti-Inflammatory Agents; Anticoagulants; Blood Proteins; Chromatography, High Pressure Liquid; Drug Interactions; Female; Hematocrit; Humans; Hydroxylation; Hydroxyurea; Ibuprofen; In Vitro Techniques; Isotope Labeling; Lipoxygenase Inhibitors; Male; Naproxen; Prednisolone; Protein Binding; Salicylates; Stereoisomerism; Terfenadine; Theophylline; Warfarin

1995
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.
    Journal of medicinal chemistry, 1997, Feb-28, Volume: 40, Issue:5

    Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Drug Design; Humans; Hydroxyurea; Ibuprofen; Indomethacin; Leukocytes; Leukotriene E4; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Naproxen; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tumor Cells, Cultured

1997
Blockade of cytosolic phospholipase A2 alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses.
    Journal of neuroimmunology, 2008, Nov-15, Volume: 204, Issue:1-2

    Topics: Analysis of Variance; Animals; Benzoates; Cell Proliferation; Cells, Cultured; Cyclooxygenase Inhibitors; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Glycoproteins; Group IV Phospholipases A2; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Myelin-Oligodendrocyte Glycoprotein; Naproxen; Peptide Fragments; Severity of Illness Index; Seveso Accidental Release; Sulfonamides; Th1 Cells; Time Factors

2008
Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Gene Expression; Hydroxyurea; Lipoxygenase Inhibitors; Male; Mouth Neoplasms; Naproxen; Piroxicam; Pyrazoles; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Up-Regulation

2010