hydroxyurea and melphalan

hydroxyurea has been researched along with melphalan in 46 studies

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199021 (45.65)18.7374
1990's8 (17.39)18.2507
2000's7 (15.22)29.6817
2010's10 (21.74)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hansch, C; Khwaja, TA; Selassie, CD1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Hammond, CB; Schmidt, HJ; Suciu, TN; Surwit, EA1
Hunter, JA1
Cheung, NK; Exelby, PR; Gulati, SC; Kushner, BH; Kwon, JH; O'Reilly, RJ1
Blanc, AP; Carcassonne, Y; Cebe, G; Jullien-Depradeux, AM; Pedinielli, FJ; Routy, JP; Taillan, B1
Portnoĭ, AS1
Ben-Efraim, S; Berko, R; Bocian, RC; Colvin, M; Dray, S; Seissman, K1
Jacobs, EM; Johnson, FD1
Dominick, CA; Dykes, DJ; Griswold, DP; Kelley, CA; Roberts, BJ1
Carter, SK2
Delobel, J; Dresch, C; Najean, Y; Pecking, A; Rain, JD1
Burns, BC; Rutledge, F; Smith, JP; Soffar, S1
Donaldson, MH; Fernbach, DJ; Lane, DM; Lonsdale, D; Sutow, WW; Vietti, TJ1
Berry, DH; Holcomb, TM; Lonsdale, D; Nora, AH; Sullivan, MP; Thurman, WG; Vietti, TJ1
Hills, WJ; Rufino, C; Stehlin, JS1
Meistrich, ML; Meyn, RE; White, RA1
Didlake, R; Files, JC; Kirchner, KA; Krueger, RP; Raju, S1
Dantas, M; Drebing, C; Glode, LM; Koeppler, H; Robinson, WA; Thomas, MR1
Anisimowicz, J; Mizan, K1
Hansson, J; Lewensohn, R; Ringborg, U1
Schmidt, JD1
Beere, HM; Chapman, RS; Chresta, CM; Dive, C; Heer, S; Herberg, AA; Hickman, JA; Whetton, AD1
Chapman, RS; Chresta, CM; Dive, C; Whetton, AD1
Berger, NA; Chatterjee, S; Cheng, MF1
Chapman, RS; Dive, C; Whetton, AD1
Heinemann, V; Jehn, U; Pötscher, C1
Fisher, SG; Godwin, J; Nand, S; Stock, W1
Calori, R; Colombi, M; Onida, F; Radaelli, F; Rossi, FG; Usardi, P; Zanella, A; Zilioli, VR1
Ahmann, DL; Bisel, HF; Hahn, RG1
Deng, L; Wu, T; Yan, X; Zhang, J1
Barbagallo, I; Chiarenza, A; Conticello, C; Del Fabro, V; Di Raimondo, F; Giallongo, C; La Cava, P; Palumbo, GA; Parrinello, N; Romano, A; Stagno, F; Tibullo, D1
Deng, L; Lawrie, TA; Wu, T; Zhang, J1
Alsina, M; Hassoun, Y; Kharfan-Dabaja, MA; Nishihori, T; Shain, K; Zhang, L1
Adachi, H; Uematsu, Y; Yamada, T1
Abraham, A; Cluster, A; Delgado, D; Hulbert, ML; Jacobsohn, D; Kukadiya, D; Murray, L; Shenoy, S1
Anaclerico, B; Andriani, A; Aroldi, A; Breccia, M; Carmosino, I; Centra, A; Di Veroli, A; Elli, E; Fianchi, L; Foà, R; Latagliata, R; Martini, V; Montanaro, G; Montanaro, M; Niscola, P; Trapè, G; Villivà, N; Voso, MT1

Reviews

7 review(s) available for hydroxyurea and melphalan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Cutaneous malignant melanoma.
    International journal of dermatology, 1976, Volume: 15, Issue:9

    Topics: Adult; Aged; Biopsy; Carmustine; Cyclophosphamide; Dactinomycin; Female; Humans; Hydroxyurea; Male; Melanoma; Melphalan; Microscopy, Electron; Middle Aged; Prognosis; Skin Neoplasms; Sunlight; Wounds and Injuries

1976
[Chemotherapy of prostatic cancer].
    Voprosy onkologii, 1985, Volume: 31, Issue:9

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Dacarbazine; Diethylstilbestrol; Doxorubicin; Estramustine; Fluorouracil; Humans; Hydroxyurea; Male; Melphalan; Methotrexate; Mitomycin; Mitomycins; Prednisolone; Procarbazine; Prostatic Neoplasms; Streptozocin; Vincristine

1985
Single and combination nonhormonal chemotherapy in breast cancer.
    Cancer, 1972, Volume: 30, Issue:6

    Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Drug Synergism; Female; Fluorouracil; Humans; Hydroxyurea; Melphalan; Menopause; Methotrexate; Mice; Vinblastine; Vincristine

1972
An overview of the status of the nitrosoureas in other tumors.
    Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:3

    Topics: Adenocarcinoma; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Carmustine; Cyclohexanes; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Hodgkin Disease; Humans; Hydroxyurea; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Melanoma; Melphalan; Multiple Myeloma; Nitrosourea Compounds; Prednisone; Vincristine

1973
Combination chemotherapy for high-risk gestational trophoblastic tumour.
    The Cochrane database of systematic reviews, 2009, Apr-15, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Gestational Trophoblastic Disease; Humans; Hydatidiform Mole; Hydroxyurea; Melphalan; Methotrexate; Pregnancy; Trophoblastic Tumor, Placental Site; Vincristine

2009
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
    The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dactinomycin; Doxorubicin; Early Termination of Clinical Trials; Female; Gestational Trophoblastic Disease; Humans; Hydatidiform Mole; Hydroxyurea; Leucovorin; Melphalan; Methotrexate; Pregnancy; Trophoblastic Tumor, Placental Site; Vincristine

2013

Trials

3 trial(s) available for hydroxyurea and melphalan

ArticleYear
Successful treatment of accelerated and blastic phase of chronic myeloid leukemia with high-dose interferon alpha and hydroxyurea: a novel approach.
    Leukemia & lymphoma, 1995, Volume: 19, Issue:1-2

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Bone Marrow Transplantation; Busulfan; Combined Modality Therapy; Cytarabine; Humans; Hydroxyurea; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Melphalan; Middle Aged

1995
Clinical evaluation of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxam-ide (NSC-45388), melphalan (NSC-8806), and hydroxyurea (NSC-32065) in the treatment of disseminated malignant melanoma.
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Dacarbazine; Female; Humans; Hydroxyurea; Leukocytes; Male; Melanoma; Melphalan; Middle Aged; Remission Induction; Treatment Outcome

1972
Unrelated Umbilical Cord Blood Transplantation for Sickle Cell Disease Following Reduced-Intensity Conditioning: Results of a Phase I Trial.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2017, Volume: 23, Issue:9

    Topics: Alemtuzumab; Anemia, Sickle Cell; Calcineurin Inhibitors; Child; Child, Preschool; Cord Blood Stem Cell Transplantation; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Hydroxyurea; Male; Melphalan; Mycophenolic Acid; Survival Analysis; Thiotepa; Transplantation Conditioning; Transplantation, Homologous; Treatment Outcome; Unrelated Donors; Vidarabine

2017

Other Studies

36 other study(ies) available for hydroxyurea and melphalan

ArticleYear
Structure-activity relationships of antineoplastic agents in multidrug resistance.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured

1990
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A new combination chemotherapy for resistant trophoblastic disease.
    Gynecologic oncology, 1979, Volume: 8, Issue:1

    Topics: Adult; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Drug Resistance; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Leucovorin; Melphalan; Methotrexate; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms; Vincristine

1979
High-dose melphalan with 6-hydroxydopamine-purged autologous bone marrow transplantation for poor-risk neuroblastoma.
    Cancer, 1991, Jul-15, Volume: 68, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dianhydrogalactitol; Doxorubicin; Female; Fluorouracil; Humans; Hydroxydopamines; Hydroxyurea; Infant; Male; Melphalan; Neoplasm Staging; Neuroblastoma; Oxidopamine; Prognosis; Radiotherapy Dosage; Remission Induction; Survival Rate; Vincristine; Whole-Body Irradiation

1991
[Association of Biermer's anemia with chronic myeloid leukemia. A case report].
    Presse medicale (Paris, France : 1983), 1985, Sep-14, Volume: 14, Issue:30

    Topics: Anemia, Pernicious; Humans; Hydroxyurea; Leukemia, Myeloid; Male; Melphalan; Middle Aged

1985
Tumoricidal and immunomodulatory activities of drugs and implications for therapy of mice bearing a late stage MOPC-315 plasmacytoma.
    International journal of immunopharmacology, 1988, Volume: 10, Issue:7

    Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Carmustine; Cell Division; Cyclophosphamide; Female; Hydroxyurea; Immunity; Melphalan; Methylnitrosourea; Mice; Mice, Inbred BALB C; Plasmacytoma; Spleen

1988
Chemotherapy of metastatic malignant melanoma. Experience with 73 patients.
    Cancer, 1971, Volume: 27, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Eye Neoplasms; Female; Floxuridine; Humans; Hydroxyurea; Idoxuridine; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Metastasis; Nitrogen Mustard Compounds; Nitrosourea Compounds; Skin Neoplasms; Vinblastine; Vincristine; Vulvar Neoplasms

1971
Approaches to combination chemotherapy in rat, mouse, and hamster tumors.
    Cancer chemotherapy reports. Part 2, 1974, Volume: 4, Issue:1

    Topics: Adenocarcinoma; Amides; Androstanols; Animals; Antineoplastic Agents; Cricetinae; Cyclohexanes; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Therapy, Combination; Estradiol; Female; Hydroxyurea; Imidazoles; Mammary Neoplasms, Experimental; Melanoma; Melphalan; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Osteosarcoma; Plasmacytoma; Progesterone; Rats; Sarcoma, Experimental; Triazenes

1974
[Choice of treatment in polycythemia vera. 1. Efficacy of chemotherapy].
    La Nouvelle presse medicale, 1973, May-26, Volume: 2, Issue:21

    Topics: Chlorambucil; Humans; Hydroxyurea; Melphalan; Phosphorus Isotopes; Polycythemia Vera; Remission, Spontaneous; Time Factors

1973
Systemic chemotherapy for carcinoma of the cervix.
    American journal of obstetrics and gynecology, 1967, Mar-15, Volume: 97, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fluorouracil; Humans; Hydroxyurea; Mechlorethamine; Melphalan; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Progestins; Thiotepa; Urea; Uterine Cervical Neoplasms

1967
Evaluation of chemotherapy in children with metastatic Ewing's sarcoma and osteogenic sarcoma.
    Cancer chemotherapy reports, 1971, Volume: 55, Issue:1

    Topics: Adolescent; Amines; Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Hydroxyurea; Male; Melphalan; Neoplasm Metastasis; Nitrosourea Compounds; Osteosarcoma; Sarcoma, Ewing; Triazines; Uracil Mustard; Vincristine

1971
Chemotherapeutic trials in patients with metastatic retinoblastoma.
    Cancer chemotherapy reports, 1968, Volume: 52, Issue:6

    Topics: Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Hydroxyurea; Infant; Male; Melphalan; Neoplasm Metastasis; Retinoblastoma; Uracil Mustard; Vincristine

1968
Disseminated melanoma. Biologic behavior and treatment.
    Archives of surgery (Chicago, Ill. : 1960), 1967, Volume: 94, Issue:4

    Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Hydrazines; Hydroxyurea; Lymph Node Excision; Lymphatic Metastasis; Melanoma; Melphalan; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Perfusion; Vincristine

1967
Cycle-dependent anticancer drug cytotoxicity in mammalian cells synchronized by centrifugal elutriation.
    Journal of the National Cancer Institute, 1980, Volume: 64, Issue:5

    Topics: Animals; Antineoplastic Agents; Bleomycin; Cell Cycle; Cell Separation; Cell Survival; Cells, Cultured; Cisplatin; Cricetinae; Cricetulus; Cytarabine; Doxorubicin; Female; Hydroxyurea; Interphase; Melphalan; Mesylates; Metaphase; Ovary

1980
Chronic granulocytic leukemia after renal transplantation.
    Archives of internal medicine, 1983, Volume: 143, Issue:10

    Topics: Adult; Allopurinol; Azathioprine; Humans; Hydroxyurea; Kidney Transplantation; Leukemia, Myeloid; Male; Melphalan; Postoperative Complications; Prednisone

1983
Autologous marrow transplantation for patients with chronic myelogenous leukemia (CML) in blast crisis.
    American journal of hematology, 1984, Volume: 16, Issue:2

    Topics: Adult; Bone Marrow Transplantation; Cytarabine; Daunorubicin; Doxorubicin; Female; Freezing; Humans; Hydroxyurea; Leukemia, Myeloid; Male; Melphalan; Middle Aged; Teniposide; Thioguanine; Tissue Preservation; Transplantation, Autologous

1984
[Case of plasmacytic leukemia with complete remission and 1-year survival after a combined 5-drug sequence therapy].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1984, Sep-03, Volume: 39, Issue:36

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Ethamsylate; Female; Humans; Hydroxyurea; Leukemia, Plasma Cell; Melphalan; Prednisone; Time Factors

1984
Different activities of unscheduled DNA synthesis in human melanoma and bone marrow cells.
    Cancer research, 1982, Volume: 42, Issue:1

    Topics: Bone Marrow; Cell Line; DNA Repair; DNA Replication; DNA, Neoplasm; Female; Humans; Hydroxyurea; Male; Melanoma; Melphalan; Neoplasm Metastasis; Ultraviolet Rays

1982
Chemotherapy of hormone-resistant stage D prostatic cancer.
    The Journal of urology, 1980, Volume: 123, Issue:6

    Topics: Cisplatin; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Estramustine; Fluorouracil; Humans; Hydroxyurea; Lomustine; Male; Melphalan; Methotrexate; Prednimustine; Prostatic Neoplasms

1980
Further characterisation of the in situ terminal deoxynucleotidyl transferase (TdT) assay for the flow cytometric analysis of apoptosis in drug resistant and drug sensitive leukaemic cells.
    Cytometry, 1995, Jul-01, Volume: 20, Issue:3

    Topics: Abelson murine leukemia virus; Antineoplastic Agents; Apoptosis; Cell Nucleus; DNA Damage; DNA Nucleotidylexotransferase; DNA, Neoplasm; Drug Resistance, Neoplasm; Etoposide; Flow Cytometry; HL-60 Cells; Humans; Hydroxyurea; Leukemia; Melphalan; Oncogene Proteins v-abl; Protein-Tyrosine Kinases; Recombinant Proteins; Tumor Cells, Cultured

1995
Characterization of drug resistance mediated via the suppression of apoptosis by Abelson protein tyrosine kinase.
    Molecular pharmacology, 1995, Volume: 48, Issue:2

    Topics: Abelson murine leukemia virus; Animals; Apoptosis; Cell Cycle; Cell Line; DNA; DNA Damage; Drug Resistance; Hydroxyurea; Interleukin-3; Melphalan; Mice; Naphthalenes; Protein Kinase C; Protein-Tyrosine Kinases

1995
Schedule-dependent cytotoxicity of topotecan alone and in combination chemotherapy regimens.
    Oncology research, 1994, Volume: 6, Issue:6

    Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Aphidicolin; Camptothecin; Carmustine; Cell Cycle; Cell Death; Cell Line; Cisplatin; Cricetinae; Cricetulus; DNA Damage; DNA Repair; DNA, Neoplasm; Doxorubicin; Drug Synergism; Etoposide; Fibroblasts; Hydroxyurea; Lung; Melphalan; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan

1994
The suppression of drug-induced apoptosis by activation of v-ABL protein tyrosine kinase.
    Cancer research, 1994, Oct-01, Volume: 54, Issue:19

    Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Enzyme Activation; Hydroxyurea; Melphalan; Mice; Oncogene Proteins v-abl; Protein-Tyrosine Kinases

1994
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
    American journal of hematology, 1996, Volume: 52, Issue:1

    Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Busulfan; Cell Transformation, Neoplastic; Chlorambucil; Cohort Studies; Disease Progression; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Hydroxyurea; Incidence; Interferon-alpha; Leukemia; Leukemia, Radiation-Induced; Male; Melphalan; Middle Aged; Phlebotomy; Phosphorus Radioisotopes; Polycythemia Vera; Preleukemia; Primary Myelofibrosis; Retrospective Studies; Ribonucleotide Reductases; Risk; Thrombocythemia, Essential

1996
Second malignancies in essential thrombocythemia (ET): a retrospective analysis of 331 patients with long-term follow-up from a single institution.
    Hematology (Amsterdam, Netherlands), 2008, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkylating Agents; Busulfan; Drug Therapy, Combination; Female; Follow-Up Studies; Hematologic Neoplasms; Humans; Hydroxyurea; Male; Melphalan; Middle Aged; Neoplasms, Second Primary; Retrospective Studies; Thrombocythemia, Essential; Young Adult

2008
Imatinib increases cytotoxicity of melphalan and their combination allows an efficient killing of chronic myeloid leukemia cells.
    European journal of haematology, 2011, Volume: 86, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Cycle; Cytarabine; DNA Damage; Drug Synergism; Gene Expression; Genes, abl; Humans; Hydroxyurea; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melphalan; Piperazines; Pyrimidines; Tumor Stem Cell Assay

2011
High-dose melphalan produces favorable response in a patient with multiple myeloma and coexisting essential thrombocythemia with JAK2 mutation.
    Bone marrow transplantation, 2014, Volume: 49, Issue:1

    Topics: Bone Marrow; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Janus Kinase 2; Melphalan; Middle Aged; Multiple Myeloma; Mutation; Myeloablative Agonists; Platelet Count; Thrombocythemia, Essential; Treatment Outcome

2014
Evaluation of the RBC Pig-a and PIGRET assays using single doses of hydroxyurea and melphalan in rats.
    Mutation research. Genetic toxicology and environmental mutagenesis, 2016, Nov-15, Volume: 811

    Topics: Animals; Erythrocytes; Hydroxyurea; Male; Melphalan; Membrane Proteins; Mutagenicity Tests; Mutagens; Rats; Rats, Sprague-Dawley; Reticulocytes

2016
Treatment of Philadelphia-negative myeloproliferative neoplasms in accelerated/blastic phase with azacytidine. Clinical results and identification of prognostic factors.
    Hematological oncology, 2019, Volume: 37, Issue:3

    Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Blast Crisis; Female; Humans; Hydroxyurea; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Male; Melphalan; Middle Aged; Mutation; Myeloproliferative Disorders; Pipobroman; Polycythemia Vera; Primary Myelofibrosis; Prognosis; Remission Induction; Retrospective Studies; Thrombocythemia, Essential; Treatment Outcome

2019
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