hydroxyurea and leukotriene b4

hydroxyurea has been researched along with leukotriene b4 in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	46 (56.10)	18.2507
2000's	20 (24.39)	29.6817
2010's	14 (17.07)	24.3611
2020's	2 (2.44)	2.80

Authors

Authors	Studies
Grisham, MB; Keenan, CM; Vaananen, PM; Wallace, JL	1
Greco, MN; Hageman, WE; Persico, FJ; Powell, ET; Tighe, JJ	1
Abraham, WM; Ahmed, A; Bell, RL; Bouska, J; Cortes, A; Hinz, W; Lanni, C; Sielczak, MW	1
Coblyn, JS; Helfgott, S; Henson, B; Kremer, JM; Maier, AL; Petrillo, G; Rubin, P; Sperling, R; Weinblatt, ME	1
Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER	1
Desai, SN; Jamieson-Leclercq, T; Noonan, TC	1
Chan, CC; Foster, A; Guay, J; Riendeau, D; Wolfe, S	1
Borgeat, P; Dubé, L; Kesterson, J; Lauzière, M; Rubin, P; Sirois, P	1
Knapp, HR	1
Garland, LG; Jackson, WP; Salmon, JA	1
Albert, DH; Bell, RL; Bouska, J; Brooks, DW; Carter, GW; Dyer, R; Summers, JB; Young, PR	1
Barnes, NC; Barnes, PJ; Hui, KP; Kesterson, J; Rubin, P; Taylor, GW; Taylor, IK	1
Bukhave, K; Lauritsen, K; Laursen, LS; Naesdal, J; Rask-Madsen, J	1
Fuller, BJ; Green, CJ; Lane, NJ; Manek, S; Thorniley, MS	1
Kimble, EF; Kowalski, TJ; Peters, PA; Powers, C; Satoh, Y; Toledo, LM	1
Bell, RL; Bouska, JB; Brooks, DW; Carter, GW; Harris, RR; Lanni, C; Malo, PE; Otis, ER; Stewart, AO	1
Guidot, DM; Repine, JE; Repine, MJ; Westcott, JY	1
Bell, RL; Brooks, DW; Carter, GW; Hansen, R; Lanni, C; Malo, PE; Rubin, P; Stewart, AO	1
Breton, J; Chabot-Fletcher, M; DeWolf, W; Griswold, D; Hillegass, L; Keller, P	1
Anderson, CB; Mangino, MJ; Murphy, MK	1
Bell, RL; Bouska, J; Brooks, DW; Carter, GW; Lanni, C; Machinist, J; Malo, PE; Summers, JB; Young, PR	1
Chertock, H; DiPasquale, G; Koeler, J; Peppard, J; Raychaudhuri, A; White, WD	1
Colombo, C; DiPasquale, G; Fryer, LR; Greenspan, PD; Haston, W; Healy, C; Kotyuk, B; Pastor, G; Pellas, TC; Raychaudhuri, A	1
Bishop, MJ; Chi, EY; Henderson, WR; Su, M	1
Berkenkopf, JW; Carlson, RP; Grimes, D; Kreft, AF; Marinari, LR; Musser, JH; Sturm, RJ; Weichman, BM	1
Carlson, RP; Glaser, K; Grimes, D; Gunawan, I; Hartman, DA; Howell, R; Kanzelberger, M; Malamas, MS; Nelson, JA; Shah, U	1
Clausen, M; Gautschi, K; Reinboth, JJ; Remé, CE	1
Cohn, J; Dworski, R; Fish, JE; Kane, GC; Kim, CJ; Murray, JJ; Peters, SP; Pollice, M; Sheller, J; Tollino, M	1
Medvedeff, ED; Nickerson-Nutter, CL	1
Awni, WM; Braeckman, RA; Cavanaugh, JH; Dubé, LM; Granneman, GR; Linnen, PJ; Locke, CS	1
Awni, WM; Braeckman, RA; Dubé, LM; Granneman, GR; Witt, G	1
Bleecker, ER; Cohn, J; Hasday, JD; Meltzer, SS	1
Harada, K; Hibi, S; Kawahara, T; Kobayashi, N; Miyamoto, K; Numata, H; Okamoto, Y; Shinoda, M; Tagami, K; Yamatsu, I	1
Broutman, L; Callaghan, C; Doria, MI; Eiznhamer, D; Keshavarzian, A; Zarif, A	1
Bell, RL; Brooks, CD; Huang, R; Hulkower, KI; Otis, ER; Pollock, JS; Walsh, RE	1
Bell, RL; Carter, GW; Goodfellow, C; Harris, RR; Namovic, MT; Walsh, RE	1
Douglas, I; Herrnreiter, A; Leff, AR; Mayer, D; Muñoz, NM; Zhu, X	1
Carpentier, PJ; Drajesk, JF; Joos, GF; Kips, JC; Pauwels, RA; Van Schoor, J	1
Bachelet, M; Bureau, MF; Cortese, C; De Castro, CM; Vargaftig, BB	1
Kotadia, B; Mangino, JE; Mangino, MJ; Sielczak, M	1
Klasing, KC; Korver, DR; Wakenell, P	1
Bell, RL; Carter, GW; Harris, RR; Wilcox, D	1
Aoki, Y; Kao, PN; Qiu, D; Zhao, GH	1
Bouboulis, D; Frieri, M; Lark, G; Sansone, G; Schaefer, PA; Therattil, JM; Wang, SF; Zitt, M	1
Abraham, WM; Ahmed, A; Botvinnikova, Y; Lauredo, IT; Sabater, JR	1
Hardy, DB; Pereria, LE; Yang, K	1
Hirasawa, N; Kushihara, M; Ohuchi, K; Takahagi, H; Takasaki, W; Takayanagi, M; Yamashita, M	1
Heerschap, A; Mayatepek, E; Rotteveel, JJ; Steijlen, PM; Willemsen, MA	1
Dugas, B	1
Agustí, C; Cardell, LO; Nadel, JA	1
Bizer, C; Schapowal, A; Simon, HU; Thomet, OA; Wiesmann, UN	1
Harada, K; Inoue, T; Nagakura, N; Oketani, K	1
Alcaraz, MJ; Guillén, MI; Vicente, AM	1
Coffey, MJ; Peters-Golden, M; Phare, SM	1
Gershwin, ME; Morrissey, BM; Naguwa, S; Vang, K; Watnik, M; Wineinger, J; Ziboh, VA	1
Britti, D; Chatterjee, PK; Cuzzocrea, S; Di Paola, R; Patel, NS; Sautebin, L; Thiemermann, C	1
Beer, DG; Chen, X; Giordano, TJ; Jin, Z; Lin, Y; Lubet, RA; Shih, WC; Sood, S; Wang, P; Wang, S; Wu, N; Yang, CS	1
Kulkarni, SK; Kumar, M; Patil, CS; Singh, VP	1
Aronoff, DM; Canetti, C; Chen, GH; Choe, M; Flamand, N; Peters-Golden, M; Toews, GB; Wettlaufer, S	1
Dahlén, B; Dahlén, SE; Delin, I; Gaber, F; James, A; Kumlin, M; Sampson, AP; Wetterholm, A	1
Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Jiang, X; Karlsson, L; Lundeen, KA; Rao, NL; Riley, JP; Williams, KN; Xue, X	1
Andoh, T; Kamimura, K; Kawai, S; Kuraishi, Y; Nakano, T; Nojima, H; Ohtsuka, E	1
Dastidar, SG; Kakar, S; Paliwal, JK; Ray, A; Salman, M; Sattigeri, V; Sharma, P; Shirumalla, RK; Singh Saini, G; Varshney, B	1
Anderson, GD; De Ciechi, PA; Keys, KL; Masferrer, JL	1
Ayers, DC; Fanning, PJ; Gaur, T; Lian, JB; Mason-Savas, A; O'Connell, SL; Silva, J; Stein, GS; Wixted, JJ	1
Alestas, T; Seltmann, H; Zouboulis, CC	1
Hu, JH; Li, FQ; Liu, JY; Liu, YX; Pan, YH; Peng, C; Wang, XR; Wu, L; Xu, JG; You, BM; Zhu, QG; Zhu, Y	1
Brotz, TM; Cossette, M; Grégoire, JC; Ibrahim, R; Kouz, S; L'allier, PL; Lavoie, MA; Nozza, A; Paquin, J; Pressacco, J; Tardif, JC; Taub, R	1
Boschi, D; Cena, C; Coruzzi, G; Di Stilo, A; Fruttero, R; Gasco, A; Giorgis, M; Guaita, E; Morini, G; Talniya, NC	1
Albert, RK; Bailey, WC; Casaburi, R; Connett, JE; Cooper, JA; Criner, GJ; Curtis, JL; Dransfield, MT; Han, MK; Harnden, SM; Kim, V; Lazarus, SC; Marchetti, N; Martinez, FJ; McEvoy, CE; Niewoehner, DE; Reilly, JJ; Rice, K; Scanlon, PD; Scharf, SM; Sciurba, FC; Washko, GR; Woodruff, PG	1
Andoh, T; Honma, A; Kitazawa, K; Kuraishi, Y; Sakai, K; Urashima, M	1
Fan, B; Gao, W; Li, B; Li, M; Liu, H; Qu, X; Shao, Q; Wang, Q; Wen, Z; Xie, Q; Yang, Y; Yu, J; Zhao, F	1
Andoh, T; Kuraishi, Y; Takayama, Y	1
Bujalska-Zadrozny, M; Gasinska, E; Maslinski, S; Rzodkiewicz, P	1
Altavilla, D; Arcoraci, V; Bitto, A; Galfo, F; Irrera, N; Macrì, A; Minutoli, L; Pallio, G; Pizzino, G; Squadrito, F; Squadrito, G	1
Cheon, HG; Choi, HE; Kwak, HJ	1
Akyol, O; Huang, L; McBride, DW; Sherchan, P; Wang, Y; Zhang, JH	1
Hashim, AA; Helmy, MM; Mouneir, SM	1
Ahmadieh, H; Hafezi-Moghadam, A; Ishibashi, T; Ishikawa, K; Kanavi, MR; Koga, T; Nakama, T; Nakao, S; Ohba, M; Okuno, T; Penninger, JM; Saeki, K; Sasaki, F; Sonoda, KH; Yokomizo, T; Yoshida, S	1
Alvarez, ML; Carrillo, MC; Ceballos, MP; Comanzo, CG; Lorenzetti, F; Lucci, A; Monti, JA; Pisani, GB; Quiroga, AD; Ronco, MT; Tordjmann, T; Vera, MC	1
Baek, SE; Choi, JM; Jang, EJ; Jeon, EY; Kim, CD; Kim, JO	1
Aleluia, MM; Borges, VM; Carvalho, GQ; Carvalho, MOS; Ferreira, JRD; Filho, JR; Goncalves, MS; Guarda, CC; Lima, JB; Lyra, IM; Maffili, VV; Nascimento, VML; Oliveira, RR; Pitanga, TN; Santana, SS; Santiago, RP; Zanette, DL	1

Trials

13 trial(s) available for hydroxyurea and leukotriene b4

Article	Year
Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis. The Journal of rheumatology, 1992, Volume: 19, Issue:10 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Time Factors	1992
Effect of Zileuton (A-64077) on the 5-lipoxygenase activity of human whole blood ex vivo. Agents and actions, 1991, Volume: 34, Issue:1-2 Topics: Adolescent; Adult; Arachidonate 5-Lipoxygenase; Calcimycin; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Hydroxyurea; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Radioimmunoassay	1991
Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. The New England journal of medicine, 1990, Dec-20, Volume: 323, Issue:25 Topics: Double-Blind Method; Female; Histamine Release; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Nasal Obstruction; Nasal Provocation Tests; Prostaglandin D2; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sneezing	1990
Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax, 1991, Volume: 46, Issue:3 Topics: Adult; Allergens; Asthma; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; SRS-A; Time Factors	1991
Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. Prostaglandins, 1995, Volume: 50, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cross-Over Studies; Dinoprost; Dinoprostone; Double-Blind Method; Eosinophils; Humans; Hydroxyurea; Leukotriene B4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Lung; Lung Injury; Placebos; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Proteins; Regression Analysis; Respiratory Hypersensitivity; Thromboxane B2	1995
The pharmacokinetic and pharmacodynamic interactions between the 5-lipoxygenase inhibitor zileuton and the cyclo-oxygenase inhibitor naproxen in human volunteers. Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2 Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Endoscopy; Humans; Hydroxyurea; Intestinal Mucosa; Leukotriene B4; Lipoxygenase Inhibitors; Male; Naproxen; Thromboxane B2	1995
Pharmacokinetics and pharmacodynamics of zileuton after oral administration of single and multiple dose regimens of zileuton 600mg in healthy volunteers. Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2 Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fasting; Humans; Hydroxylation; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Stereoisomerism; Urea; White People	1995
Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:3 Topics: Adult; Albuterol; Anti-Asthmatic Agents; Asthma, Exercise-Induced; Bronchial Spasm; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Inflammation Mediators; Leukotriene Antagonists; Leukotriene B4; Leukotriene C4; Leukotrienes; Lipoxygenase Inhibitors; Vital Capacity	1996
The effect of ABT-761, a novel 5-lipoxygenase inhibitor, on exercise- and adenosine-induced bronchoconstriction in asthmatic subjects. American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:3 Topics: Adenosine; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Exercise; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Vasodilator Agents	1997
Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma. Clinical & developmental immunology, 2004, Volume: 11, Issue:1 Topics: Adult; Aged; Arthritis, Rheumatoid; Asthma; Dietary Supplements; Double-Blind Method; Fatty Acids; Female; gamma-Linolenic Acid; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Neutrophils; Plant Oils; Prospective Studies	2004
Assessment of in vivo 5-lipoxygenase activity by analysis of leukotriene B4 in saliva: effects of treatment with zileuton. The Journal of allergy and clinical immunology, 2007, Volume: 119, Issue:5 Topics: Adult; Arachidonate 5-Lipoxygenase; Chromatography, High Pressure Liquid; Double-Blind Method; Evaluation Studies as Topic; Female; Flow Cytometry; Humans; Hydroxyurea; Leukocytes, Mononuclear; Leukotriene Antagonists; Leukotriene B4; Male; Middle Aged; Saliva	2007
Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome. Circulation. Cardiovascular imaging, 2010, Volume: 3, Issue:3 Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Analysis of Variance; Arachidonate 5-Lipoxygenase; Biomarkers; C-Reactive Protein; Contrast Media; Coronary Angiography; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxyurea; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Observer Variation; Prospective Studies; Radiographic Image Enhancement; Tomography, X-Ray Computed; Treatment Outcome; Triiodobenzoic Acids	2010
Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. COPD, 2011, Volume: 8, Issue:1 Topics: Aged; Biomarkers; Double-Blind Method; Drug Administration Schedule; Female; Hospitalization; Humans; Hydroxyurea; Length of Stay; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Treatment Failure; Treatment Outcome	2011

Other Studies

69 other study(ies) available for hydroxyurea and leukotriene b4

Article	Year
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Inflammation, 1992, Volume: 16, Issue:3 Topics: 5-Lipoxygenase-Activating Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Benzopyrans; Carrier Proteins; Free Radical Scavengers; Gastric Mucosa; Hydroxyurea; Indoles; Indomethacin; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Masoprocol; Membrane Proteins; Organic Chemicals; Permeability; Phenylcarbamates; Propionates; Quinolines; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene; Receptors, Leukotriene B4; Single-Blind Method; Stomach Ulcer; Sulfonamides; Tetrazoles; Tosyl Compounds	1992
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid. Journal of medicinal chemistry, 1992, Aug-21, Volume: 35, Issue:17 Topics: Animals; Benzothiazoles; Calcimycin; Dogs; Humans; Hydroxamic Acids; Hydroxyurea; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Methemoglobin; Mice; Molecular Structure; Peritonitis; SRS-A; Structure-Activity Relationship; Thiazoles	1992
The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep. European journal of pharmacology, 1992, Jul-07, Volume: 217, Issue:2-3 Topics: Administration, Oral; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Dose-Response Relationship, Drug; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Sheep	1992
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. British journal of pharmacology, 1992, Volume: 107, Issue:4 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2	1992
Effect of BI-L-239, A-64077 and MK-886 on leukotriene B4 synthesis by chopped guinea pig lung and on antigen-induced tracheal contraction in vitro. Prostaglandins, 1992, Volume: 44, Issue:6 Topics: Animals; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phenols; Trachea	1992
Inhibition of leukotriene B4 biosynthesis by disulfiram and A-64077 during carrageenan-induced pleurisy in the rat. General pharmacology, 1991, Volume: 22, Issue:2 Topics: Aldehyde Dehydrogenase; Animals; Carrageenan; Colitis, Ulcerative; Disulfiram; Exudates and Transudates; Humans; Hydroxyurea; In Vitro Techniques; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pleurisy; Rats; Rats, Inbred Strains	1991
Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A Topics: Administration, Oral; Animals; Benzeneacetamides; Biological Availability; Biotransformation; Calcimycin; Dogs; Drug Design; Half-Life; Humans; Hydroxamic Acids; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Rabbits; Rats; Structure-Activity Relationship	1991
5-lipoxygenase inhibitory activity of zileuton. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Chromatography, High Pressure Liquid; Dogs; Edema; Haplorhini; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Rats; Rats, Inbred Strains; Species Specificity	1991
Selective 5-lipoxygenase inhibition in ulcerative colitis. Lancet (London, England), 1990, Mar-24, Volume: 335, Issue:8691 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arachidonate Lipoxygenases; Colitis, Ulcerative; Dialysis; Dinoprostone; Drug Evaluation; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Middle Aged; Recurrence; Time Factors	1990
Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation. Transplantation, 1994, Dec-27, Volume: 58, Issue:12 Topics: Acute Kidney Injury; Animals; Capillary Permeability; Creatinine; Disease Models, Animal; Eicosanoids; Enzyme-Linked Immunosorbent Assay; Female; Graft Rejection; Graft Survival; Hydroxylamines; Hydroxyurea; Kidney Transplantation; Kidney Tubules; Leukotriene B4; Lipoxygenase Inhibitors; Methylurea Compounds; Necrosis; Organ Preservation; Prostaglandins F; Rabbits; Thromboxane B2; Urea	1994
Derivatives of 2-[[N-(Aminocarbonyl)-N-hydroxyamino]methyl]-1,4- benzodioxan as orally active 5-lipoxygenase inhibitors. Journal of medicinal chemistry, 1995, Jan-06, Volume: 38, Issue:1 Topics: Administration, Oral; Animals; Dioxanes; Dogs; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Stereoisomerism	1995
Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Haplorhini; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Rats; Stereoisomerism	1995
Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity. Proceedings of the National Academy of Sciences of the United States of America, 1994, Aug-16, Volume: 91, Issue:17 Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Adhesion; Chemotaxis, Leukocyte; Cytochrome c Group; Dose-Response Relationship, Drug; Humans; Hydroxyurea; In Vitro Techniques; Indoles; Interleukin-8; Kinetics; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate	1994
Preclinical and clinical activity of zileuton and A-78773. Annals of the New York Academy of Sciences, 1993, Nov-30, Volume: 696 Topics: Animals; Bronchial Spasm; Guinea Pigs; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Rats	1993
Use of a continuous assay of oxygen consumption to evaluate the pharmacology of 5-lipoxygenase inhibitors. Prostaglandins, leukotrienes, and essential fatty acids, 1993, Volume: 49, Issue:6 Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Drug Evaluation, Preclinical; Humans; Hydroxyurea; Imidazoles; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Monocytes; Oxygen Consumption; Rats; Tumor Cells, Cultured	1993
Effects of the arachidonate 5-lipoxygenase synthesis inhibitor A-64077 in intestinal ischemia-reperfusion injury. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:1 Topics: Animals; Arachidonate 5-Lipoxygenase; Dogs; Hydroxyurea; Intestinal Mucosa; Intestines; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Models, Biological; Neutrophils; Reperfusion Injury	1994
The properties of A-69412: a small hydrophilic 5-lipoxygenase inhibitor. Agents and actions, 1993, Volume: 38, Issue:3-4 Topics: Anaphylaxis; Animals; Biological Availability; Blood Proteins; Dogs; Half-Life; Humans; Hydroxyurea; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Macaca fascicularis; Male; Microsomes, Liver; Protein Binding; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured	1993
Effect of 5-lipoxygenase inhibitors on in situ LTB4 biosynthesis following calcium ionophore stimulation in the rat pleural cavity. Agents and actions, 1993, Volume: 39 Spec No Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Carrageenan; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Pleura; Radioimmunoassay; Rats	1993
LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists. Journal of pharmacological and toxicological methods, 1993, Volume: 30, Issue:3 Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dexamethasone; Hydroxyurea; Indomethacin; Leukocyte Count; Leukotriene B4; Male; Models, Biological; Naproxen; Neutropenia; Neutrophils; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene B4	1993
Lung mast cells increase in number and degranulate during pulmonary artery occlusion/reperfusion injury in dogs. The American review of respiratory disease, 1993, Volume: 147, Issue:2 Topics: Animals; Arterial Occlusive Diseases; Bronchoalveolar Lavage Fluid; Cell Count; Cell Degranulation; Dogs; Hydroxyurea; Leukotriene B4; Lung; Mast Cells; Microscopy, Electron; Pulmonary Artery; Reperfusion Injury; SRS-A; Thromboxane B2; Time Factors	1993
WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity. European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2 Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Female; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Naphthaleneacetic Acids; Prostaglandin-Endoperoxide Synthases; Quinolines; Rabbits; Rats; Rats, Wistar	1993
Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5-lipoxygenase. Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Bronchoconstriction; Guinea Pigs; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Molecular Structure; Monocytes; Oxazoles; Rats; Structure-Activity Relationship; Thiazoles	1996
Lipid mediators in the rat retina: light exposure and trauma elicit leukotriene B4 release in vitro. Current eye research, 1995, Volume: 14, Issue:11 Topics: Animals; Arachidonate 5-Lipoxygenase; Eicosanoids; Enzyme Activation; Hydroxyurea; Leukotriene B4; Light; Lipid Metabolism; Lipoxygenase Inhibitors; Male; Radiation Injuries, Experimental; Radioimmunoassay; Rats; Retina; Rhodopsin	1995
The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation. Arthritis and rheumatism, 1996, Volume: 39, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disease; Disease Models, Animal; Drug Combinations; Exudates and Transudates; Female; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Naproxen; Prostaglandin-Endoperoxide Synthases; Quinolines; Time Factors; Zymosan	1996
Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. Journal of medicinal chemistry, 1996, Aug-02, Volume: 39, Issue:16 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Blood Platelets; Cells, Cultured; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Methacrylates; Molecular Structure; Neutrophils; Pyridines; Rats; Structure-Activity Relationship; Thromboxane B2; Thromboxane-A Synthase	1996
The effect of a selective 5-lipoxygenase inhibitor, zileuton, on tissue damage in acute colonic inflammation in rats. Inflammation, 1996, Volume: 20, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Hydroxyurea; Intestinal Mucosa; Leukocyte Count; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mitomycin; Neutrophils; Peroxidase; Rats; Rats, Sprague-Dawley	1996
Leukotrienes do not regulate nitric oxide production in RAW 264.7 macrophages. Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 55, Issue:3 Topics: Animals; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Hydroxyurea; Interferon-gamma; Leukotriene B4; Leukotrienes; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Second Messenger Systems; Toxicity Tests	1996
Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats. European journal of pharmacology, 1996, Nov-07, Volume: 315, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Calcimycin; Dextrans; Eosinophils; Hydroxyurea; Ionophores; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pulmonary Eosinophilia; Rats; Theophylline	1996
Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:4 Topics: Animals; Cell Movement; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene B4; Leukotriene D4; Lipoxygenase Inhibitors; Male; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Phenylcarbamates; Receptors, Leukotriene; Receptors, Leukotriene B4; Sulfonamides; Tosyl Compounds; Trachea	1997
5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. European journal of pharmacology, 1997, Apr-11, Volume: 324, Issue:1 Topics: Animals; Blood Proteins; Bronchoalveolar Lavage Fluid; Bronchopulmonary Sequestration; Cell Count; Cell Separation; Dose-Response Relationship, Drug; Drug Interactions; Escherichia coli; Guinea Pigs; Hydroxylamines; Hydroxyurea; Injections, Intravenous; Isotope Labeling; Leukocytes; Leukopenia; Leukotriene B4; Leukotriene C4; Lipopolysaccharides; Lipoxygenase Inhibitors; Lung; Macrophage Activation; Macrophages, Alveolar; Methylurea Compounds; Phospholipases A; Phospholipases A2; Radioimmunoassay; Serum Albumin; Tumor Necrosis Factor-alpha	1997
Effects of the 5-lipoxygenase inhibitor A-64077 on intestinal hypothermic organ preservation injury. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:2 Topics: Animals; Cryopreservation; Dinoprostone; Dogs; Hydroxyurea; Ileum; Leukotriene B4; Lipoxygenase Inhibitors; Organ Preservation; Peroxidase	1997
Dietary fish oil or lofrin, a 5-lipoxygenase inhibitor, decrease the growth-suppressing effects of coccidiosis in broiler chicks. Poultry science, 1997, Volume: 76, Issue:10 Topics: Aging; Analysis of Variance; Animals; Body Weight; Cecum; Chickens; Coccidiosis; Corn Oil; Dietary Fats, Unsaturated; Eating; Eimeria tenella; Fatty Acids; Fish Oils; Hemopexin; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Liver; Poultry Diseases; Tumor Necrosis Factor-alpha	1997
The role of tissue mast cells in polyacrylamide gel-induced inflammation in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47, Issue:3 Topics: Acrylic Resins; Animals; Anti-Inflammatory Agents; Dinoprostone; Hydroxyurea; Inflammation; Leukocyte Count; Leukotriene B4; Lipoxygenase Inhibitors; Mast Cells; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase	1998
Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells. The American journal of physiology, 1998, Volume: 274, Issue:6 Topics: Bronchi; Cell Line; Cell Line, Transformed; Epithelial Cells; Histamine; Humans; Hydroxyurea; Indoles; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; NF-kappa B; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Quinolines; RNA, Messenger; Transfection	1998
Allergen-stimulated leukotriene B4 and interleukin-8 levels in patients with asthma and allergic rhinitis-modulation by a lipid pathway inhibitor. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 81, Issue:4 Topics: Adult; Aged; Allergens; Asthma; Female; Humans; Hydroxyurea; Interleukin-8; Leukocytes, Mononuclear; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal	1998
Mechanism of pyocyanin- and 1-hydroxyphenazine-induced lung neutrophilia in sheep airways. Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:6 Topics: Animals; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Female; Hydroxyurea; In Vitro Techniques; Interleukin-8; Leukotriene B4; Lung; Macrophages, Alveolar; Neutrophils; Phenazines; Pseudomonas aeruginosa; Pyocyanine; Sheep	1998
Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells. Biology of reproduction, 1999, Volume: 61, Issue:1 Topics: 11-beta-Hydroxysteroid Dehydrogenases; Choriocarcinoma; Dinoprost; Dinoprostone; Enzyme Inhibitors; Humans; Hydroxysteroid Dehydrogenases; Hydroxyurea; Indomethacin; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Masoprocol; Placenta; Prostaglandins; Tumor Cells, Cultured	1999
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. British journal of pharmacology, 2000, Volume: 129, Issue:2 Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone	2000
5-Lipoxygenase inhibition: a new treatment strategy for Sjögren-Larsson syndrome. Neuropediatrics, 2000, Volume: 31, Issue:1 Topics: Aldehyde Oxidoreductases; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Sjogren-Larsson Syndrome	2000
Lyprinol inhibits LTB4 production by human monocytes. Allergie et immunologie, 2000, Volume: 32, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Bivalvia; Cells, Cultured; Depression, Chemical; Gene Expression Regulation; Humans; Hydroxyurea; Interleukin-4; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Monocytes; New Zealand; Receptors, IgE; Recombinant Proteins; Respiratory Burst; Tetradecanoylphorbol Acetate	2000
Nasal secretion in ragweed-sensitized dogs: effect of leukotriene synthesis inhibition. Acta oto-laryngologica, 2000, Volume: 120, Issue:6 Topics: Animals; Dogs; Hydroxyurea; Hypersensitivity; Leukotriene Antagonists; Leukotriene B4; Nasal Mucosa; Nasal Obstruction; Nasal Provocation Tests; Neutrophils; Plants; Pollen; Rhinitis, Allergic, Seasonal; Time Factors	2000
Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. Biochemical pharmacology, 2001, Apr-15, Volume: 61, Issue:8 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Calcium; Complement C5a; Cysteine; Eosinophils; Humans; Hydroxyurea; In Vitro Techniques; Leukotriene B4; Leukotrienes; Macrophages; Neutrophils; Plant Extracts; Platelet Activating Factor; Sesquiterpenes; Signal Transduction	2001
In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production. European journal of pharmacology, 2001, Jun-22, Volume: 422, Issue:1-3 Topics: Animals; Arachidonate 5-Lipoxygenase; Benzothiazoles; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Humans; Hydroxyurea; Indomethacin; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mesalamine; Methacrylates; Neutrophils; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred F344; Sheep; Sulfasalazine; Thiazoles; Thromboxane B2; Thromboxane-A Synthase	2001
Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages. British journal of pharmacology, 2001, Volume: 133, Issue:6 Topics: Amidines; Animals; Benzylamines; Cell Line; Chick Embryo; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxyurea; Indomethacin; Isoenzymes; Leukotriene B4; Leukotriene C4; Leukotrienes; Macrophage Activation; Macrophages; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrans; Quinolones; Sulfonamides; Time Factors; Transcription Factor AP-1; Zymosan	2001
Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1 Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Nitrates; omega-N-Methylarginine; Precipitin Tests; Proteins; Rats; Rats, Wistar; Tyrosine	2001
Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. Molecular pharmacology, 2004, Volume: 66, Issue:2 Topics: Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Ischemia; Kidney Diseases; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Mice, Knockout; Neutrophils; Peroxidase; Reperfusion Injury	2004
Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Oct-01, Volume: 10, Issue:19 Topics: Adenocarcinoma; Anastomosis, Surgical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Body Weight; Celecoxib; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Esophageal Neoplasms; Humans; Hydroxyurea; Immunohistochemistry; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors	2004
Effect of 5-lipoxygenase inhibitor against lipopolysaccharide-induced hypothermia in mice. Indian journal of experimental biology, 2005, Volume: 43, Issue:12 Topics: Animals; Colon; Dinoprostone; Female; Hydroxyurea; Hypothalamus; Hypothermia; Hypothermia, Induced; Indomethacin; Leukotriene B4; Leukotrienes; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Mice	2005
Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages. Journal of leukocyte biology, 2006, Volume: 79, Issue:6 Topics: Animals; Antigen Presentation; Bone Marrow Cells; Calcium Signaling; Cells, Cultured; Dendritic Cells; Endocytosis; Enzyme Activation; Erythrocytes; Hydroxyurea; Immunoglobulin G; Indoles; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophages; Macrophages, Alveolar; Macrophages, Peritoneal; Mice; Mice, Inbred CBA; Mice, Knockout; Opsonin Proteins; Phagocytosis; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, IgG; Receptors, Leukotriene B4; Sheep; Syk Kinase	2006
Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ascitic Fluid; Benzothiazoles; Dogs; Ear; Edema; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Female; Humans; Hydroxyurea; Inflammation; Leukotriene B4; Leukotriene C4; Lipoxins; Lipoxygenase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neutrophil Infiltration; Peritonitis; Piperidines; Recombinant Proteins	2007
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice. Journal of pharmacological sciences, 2007, Volume: 105, Issue:1 Topics: Animals; Arachidonate 5-Lipoxygenase; Betamethasone Valerate; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Chromones; Cimetidine; Culicidae; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Hydroxyurea; Hypersensitivity; Indoles; Indomethacin; Ketoprofen; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Phenylpropionates; Phospholipid Ethers; Propionates; Pruritus; Quinolines; Terfenadine	2007
Pharmacodynamic and pharmacokinetic characterisation of RBx 7796: a novel 5-lipoxygenase inhibitor. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008, Volume: 57, Issue:3 Topics: Animals; Arachidonate 5-Lipoxygenase; Bronchial Hyperreactivity; Calcimycin; Dogs; Humans; Hydroxyurea; Ionophores; Leukotriene B4; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Neutrophils; Rats; Rats, Wistar; Salts	2008
Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009, Volume: 58, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Epoxide Hydrolases; Humans; Hydroxyurea; Leukotriene B4; Leukotrienes; Male; Mice; Mice, Inbred DBA; Prostaglandins; Pyrazoles; RNA, Messenger; Sulfonamides	2009
Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor. Journal of cellular physiology, 2009, Volume: 221, Issue:1 Topics: Acetates; Animals; Arachidonate 5-Lipoxygenase; Cell Proliferation; Chondrocytes; Cyclopropanes; Fracture Healing; Fractures, Bone; Gene Expression Regulation; Hydroxyurea; Hypertrophy; Leukotriene Antagonists; Leukotriene B4; Mice; Models, Biological; Osteogenesis; Quinolines; Radiography; Receptors, Leukotriene; Sulfides	2009
Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis. Experimental dermatology, 2010, Volume: 19, Issue:2 Topics: Arachidonic Acid; Cell Count; Cell Line; Humans; Hydroxyurea; Interleukin-6; Interleukin-8; Leukotriene Antagonists; Leukotriene B4; Lipogenesis; Sebaceous Glands	2010
Induction of leukotriene B(4) and prostaglandin E(2) release from keratinocytes by protease-activated receptor-2-activating peptide in ICR mice. International immunopharmacology, 2009, Volume: 9, Issue:11 Topics: Animals; Cetirizine; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Hydroxyurea; Indomethacin; Injections, Intradermal; Keratinocytes; Leukotriene B4; Male; Mice; Mice, Inbred ICR; Oligopeptides; Pruritus; Skin; Tacrolimus	2009
Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities. ChemMedChem, 2010, Sep-03, Volume: 5, Issue:9 Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Drug Design; Edema; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Nitric Oxide; Rats; Structure-Activity Relationship	2010
Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. Experimental eye research, 2012, Volume: 98 Topics: Allergens; Ambrosia; Animals; Conjunctivitis, Allergic; Disease Models, Animal; Glucocorticoids; Histamine; Histamine H1 Antagonists, Non-Sedating; Hydroxyurea; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Injections, Intraocular; Injections, Subcutaneous; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mast Cells; Mice; Mice, Inbred ICR; Phenylpropionates; Pollen; Terfenadine	2012
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration. Oncogene, 2015, Mar-05, Volume: 34, Issue:10 Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Line; Cell Line, Tumor; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Heparin-binding EGF-like Growth Factor; Heterografts; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukotriene B4; Macrophages; MAP Kinase Signaling System; Matrix Metalloproteinase 7; Mice; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Necrosis Factor-alpha	2015
Involvement of leukotriene B4 in dermatophyte-related itch in mice. Pharmacological reports : PR, 2014, Volume: 66, Issue:4 Topics: Animals; Antibodies, Monoclonal; Arthrodermataceae; Dermatomycoses; Hydroxyurea; Keratinocytes; Leukotriene Antagonists; Leukotriene B4; Male; Mice, Inbred Strains; Oligopeptides; Pruritus; Receptor, PAR-2	2014
Antinociceptive properties of esculetin in non-inflammatory and inflammatory models of pain in rats. Clinical and experimental pharmacology & physiology, 2015, Volume: 42, Issue:2 Topics: Analgesia; Analgesics; Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Hyperalgesia; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pain; Pain Threshold; Rats; Umbelliferones	2015
Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis. European journal of pharmacology, 2016, Oct-15, Volume: 789 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Body Weight; Catechin; CD3 Complex; Celecoxib; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Combinations; Eating; Gene Expression Regulation; Hydroxyurea; Leukotriene B4; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Neutrophil Infiltration; Rats; Rats, Sprague-Dawley; Thromboxane B2; Tumor Necrosis Factor-alpha	2016
5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes. Scientific reports, 2017, 07-10, Volume: 7, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Arachidonate 5-Lipoxygenase; Cell Line; Endoplasmic Reticulum Stress; Hydroxyurea; Insulin Resistance; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Muscle Fibers, Skeletal; Oxidative Stress; Palmitic Acid; Phosphorylation	2017
Naja sputatrix Venom Preconditioning Attenuates Neuroinflammation in a Rat Model of Surgical Brain Injury via PLA2/5-LOX/LTB4 Cascade Activation. Scientific reports, 2017, 07-14, Volume: 7, Issue:1 Topics: Animals; Arachidonate 5-Lipoxygenase; Biomarkers; Brain; Brain Edema; Brain Injuries; Elapid Venoms; Hydroxyurea; Inflammation; Intraoperative Complications; Leukocyte Count; Leukotriene B4; Lipoxygenase Inhibitors; Naja; Phospholipase A2 Inhibitors; Phospholipases A2; Rats; Signal Transduction; Skin; Subcutaneous Tissue; Terpenes	2017
Zileuton alleviates acute cisplatin nephrotoxicity: Inhibition of lipoxygenase pathway favorably modulates the renal oxidative/inflammatory/caspase-3 axis. Prostaglandins & other lipid mediators, 2018, Volume: 135 Topics: Animals; Caspase 3; Cisplatin; Hydroxyurea; Kidney; Leukotriene B4; Leukotriene D4; Lipoxygenases; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley	2018
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. JCI insight, 2018, 09-20, Volume: 3, Issue:18 Topics: Animals; Benzopyrans; Carboxylic Acids; Choroidal Neovascularization; Disease Models, Animal; Eye; Eye Injuries; Hydroxyurea; Indoles; Lasers; Leucine; Leukotriene B4; Macrophages; Macular Degeneration; Male; Mice; Mice, Knockout; Neovascularization, Pathologic; Receptors, Leukotriene B4; Signal Transduction	2018
Participation of 5-lipoxygenase and LTB4 in liver regeneration after partial hepatectomy. Scientific reports, 2019, 12-03, Volume: 9, Issue:1 Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Proliferation; Cyclin D1; Eicosanoids; Hepatectomy; Hydrogen-Ion Concentration; Hydroxyurea; Leukotriene B4; Leukotrienes; Liver; Liver Regeneration; Macrophages; Male; Neutrophils; NF-kappa B; Rats; Rats, Wistar; Signal Transduction	2019
5-LO-derived LTB4 plays a key role in MCP-1 expression in HMGB1-exposed VSMCs via a BLTR1 signaling axis. Scientific reports, 2021, 05-27, Volume: 11, Issue:1 Topics: Animals; Aorta; Arachidonate 5-Lipoxygenase; Chemokine CCL2; Fatty Alcohols; Glycols; HMGB1 Protein; Hydroxyurea; Leukotriene B4; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Signal Transduction	2021
Effect of lysed and non-lysed sickle red cells on the activation of NLRP3 inflammasome and LTB4 production by mononuclear cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2021, Volume: 70, Issue:7 Topics: Adolescent; Anemia, Sickle Cell; Antisickling Agents; Caspase 1; Cells, Cultured; Child; Erythrocytes; Humans; Hydroxyurea; Inflammasomes; Interleukin-18; Interleukin-1beta; Leukocytes, Mononuclear; Leukotriene B4; NLR Family, Pyrin Domain-Containing 3 Protein	2021