hydroxyurea and lamivudine

hydroxyurea has been researched along with lamivudine in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (23.33)	18.2507
2000's	13 (43.33)	29.6817
2010's	9 (30.00)	24.3611
2020's	1 (3.33)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Cox, S; Palmer, S	1
Melegari, M; Scaglioni, PP; Wands, JR	1
Back, DJ; Barry, MG; Henry-Mowatt, JS; Hoggard, PG; Kewn, S; Sales, SD; Veal, GJ	1
Boucher, CA; De Vos, NM; Nottet, HS; Orendi, JM; Snippe, H; Verhoef, J; Visser, MR	1
Alexander, CS; Harrigan, PR; Mo, T; Montaner, JS; Raboud, JM; Rae, S; Rouleau, D; Zala, C	1
Busch, M; Hecht, FM; Kahn, J; Levy, JA; Martinez-Marino, B; Ong, JC; Stranford, SA	1
Back, DJ; Hoggard, PG; Johnson, MA; Kewn, S; Sales, SD	1
Anderson, RM; Cane, PA; Ferguson, NM; Pillay, D; Taylor, S	1
Mascolini, M	1
Falkenberg, J; Gilden, D; Torres, G	1
Hanna, L	1
Adams, EM; Bennett, K; Collier, AC; Gilbert, PB; Goodwin, D; Havlir, DV; Hirsch, MS; Holohan, MK; Richman, DD; Schnittman, S; Tebas, P; Wheat, LJ	1
Bisset, LR; Böni, J; Hofmann-Lehmann, R; Lüthy, R; Lutz, H; Schüpbach, J	1
Gajary, LC; Mansky, LM; Pearl, DK	1
Almond, LM; Back, DJ; De Vries, C; Gould, J; Hoggard, PG; Kewn, S; Khoo, SH; Lou, Y; Maherbe, A; Sales, SD; Wood, R	1
Butala, N; Daver, NG; Joshi, SR; Kelkar, D; Patwardhan, MR	1
Chen, X; Chen, Z; Hou, C; Lin, Q; Liu, X; Lou, M; Qiu, Y; Shao, J; Song, R; Wang, M; Xu, Z; Yang, C; Zhu, L; Zhu, W	1

Reviews

1 review(s) available for hydroxyurea and lamivudine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for hydroxyurea and lamivudine

Article	Year
Human immunodeficiency virus-infected persons with mutations conferring resistance to zidovudine show reduced virologic responses to hydroxyurea and stavudine-lamivudine. The Journal of infectious diseases, 2000, Volume: 181, Issue:2 Topics: Anti-HIV Agents; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Hydroxyurea; Lamivudine; Logistic Models; Mutation; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; Stavudine; Viral Load; Zidovudine	2000
Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression. AIDS (London, England), 2001, Jul-27, Volume: 15, Issue:11 Topics: Adolescent; Adult; Anti-HIV Agents; Case-Control Studies; CD4 Lymphocyte Count; Drug Therapy, Combination; Enzyme Inhibitors; Female; HIV Infections; Humans; Hydroxyurea; Indinavir; Lamivudine; Male; Nucleic Acid Synthesis Inhibitors; Pancreatitis; Prospective Studies; Survival Analysis; Treatment Failure; Viral Load; Zidovudine	2001
Time-dependent changes in HIV nucleoside analogue phosphorylation and the effect of hydroxyurea. AIDS (London, England), 2002, Dec-06, Volume: 16, Issue:18 Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Drug Interactions; Drug Resistance, Viral; Female; HIV Infections; Humans; Hydroxyurea; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Nevirapine; Nucleosides; Phosphorylation; Reverse Transcriptase Inhibitors; Zidovudine	2002

Other Studies

26 other study(ies) available for hydroxyurea and lamivudine

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:2 Topics: Anti-HIV Agents; Cell Line; Deoxycytosine Nucleotides; Drug Synergism; Hydroxyurea; Lamivudine; Phosphorylation; Thymine Nucleotides; Zidovudine	1997
Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. Hepatology (Baltimore, Md.), 1998, Volume: 27, Issue:2 Topics: 2-Aminopurine; Amino Acid Sequence; Antiviral Agents; Blotting, Northern; Carcinoma, Hepatocellular; Cell Line; Famciclovir; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Hydroxyurea; Lamivudine; Liver Neoplasms; Molecular Sequence Data; Mutation; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; Transfection; Tumor Cells, Cultured; Virus Replication	1998
Intracellular activation of 2',3'-dideoxyinosine and drug interactions in vitro. AIDS research and human retroviruses, 1999, Jun-10, Volume: 15, Issue:9 Topics: Anti-HIV Agents; Deoxyadenine Nucleotides; Didanosine; Dideoxynucleotides; Drug Interactions; Guanosine; Humans; Hydroxyurea; Inosine; Intracellular Fluid; Lamivudine; Pentoxifylline; Stavudine; U937 Cells; Zidovudine	1999
Hydroxyurea interferes with antigen-dependent T-cell activation in vitro. European journal of clinical investigation, 2000, Volume: 30, Issue:2 Topics: Candida albicans; HIV-1; Humans; Hydroxyurea; Lamivudine; Lymphocyte Activation; Phytohemagglutinins; Reverse Transcriptase Inhibitors; T-Lymphocytes; Zidovudine	2000
Reduction in CD8+ cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy during primary infection. Proceedings of the National Academy of Sciences of the United States of America, 2001, Jan-16, Volume: 98, Issue:2 Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Depression, Chemical; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hydroxyurea; Immunity, Cellular; Indinavir; Lamivudine; Lymphocyte Count; Male; Middle Aged; Nelfinavir; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Treatment Refusal; Viral Load; Viremia; Zidovudine	2001
The intracellular activation of lamivudine (3TC) and determination of 2'-deoxycytidine-5'-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells. British journal of clinical pharmacology, 2000, Volume: 50, Issue:6 Topics: Anti-HIV Agents; Cell Survival; Cytidine Triphosphate; Deoxycytosine Nucleotides; Dideoxynucleotides; Drug Interactions; Humans; Hydroxyurea; Lamivudine; Methotrexate; Phosphorylation; Tumor Cells, Cultured; Vidarabine	2000
Dynamics of seminal plasma HIV-1 decline after antiretroviral treatment. AIDS (London, England), 2001, Feb-16, Volume: 15, Issue:3 Topics: Alkynes; Antiretroviral Therapy, Highly Active; Antiviral Agents; Benzoxazines; Cyclopropanes; Didanosine; Environmental Monitoring; HIV Infections; HIV-1; Humans; Hydroxyurea; Lamivudine; Male; Oxazines; Semen; Time Factors; Viral Load	2001
A Lisbon traviata. Are clinicians ready to sing addio to monotherapy and libiamo to combinations? Journal of the International Association of Physicians in AIDS Care, 1995, Volume: 1, Issue:8 Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; HIV; HIV Infections; Humans; Hydroxyurea; Indinavir; Interleukin-2; Lamivudine; Mutation; Pyridines; RNA, Viral; Zalcitabine; Zidovudine	1995
Update on clinical trials of combination therapies for HIV infection. NIAID AIDS agenda, 1995 Topics: Adult; Antiviral Agents; CD4 Lymphocyte Count; Child; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Hydroxyurea; Lamivudine; RNA-Directed DNA Polymerase; Stavudine; Zalcitabine; Zidovudine	1995
Dethroning AZT. GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1997, Volume: 11, Issue:2 Topics: Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Hydroxyurea; Lamivudine; Oxazines; Stavudine; Viral Load; Zidovudine	1997
A new approach to initial antiretroviral therapy: protease-sparing combination regimens. BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation, 1998 Topics: Alkynes; Anti-HIV Agents; Antineoplastic Agents; Benzoxazines; Clinical Trials as Topic; Cyclopropanes; Dideoxynucleosides; Drug Resistance, Microbial; Drug Therapy, Combination; Drugs, Investigational; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxyurea; Lamivudine; Lipodystrophy; Oxazines; Reverse Transcriptase Inhibitors; Time Factors; Zidovudine	1998
Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication. Antiviral research, 2002, Volume: 53, Issue:1 Topics: Animals; Anti-HIV Agents; Cats; Cell Line; Dideoxynucleosides; Drug Synergism; Drug Therapy, Combination; Feline Acquired Immunodeficiency Syndrome; Humans; Hydroxyurea; Immunodeficiency Virus, Feline; Kidney; Lamivudine; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine	2002
Combination of drugs and drug-resistant reverse transcriptase results in a multiplicative increase of human immunodeficiency virus type 1 mutant frequencies. Journal of virology, 2002, Volume: 76, Issue:18 Topics: Animals; Anti-HIV Agents; COS Cells; Dose-Response Relationship, Drug; Drug Resistance, Viral; Genetic Vectors; HeLa Cells; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Lamivudine; Mutation; Reverse Transcriptase Inhibitors; Thymidine; Virus Replication; Zidovudine	2002
Low cost anti-retroviral options: chloroquine based ARV regimen combined with hydroxyurea and lamivudine: a new economical triple therapy. The Journal of the Association of Physicians of India, 2004, Volume: 52 Topics: Anti-HIV Agents; Chloroquine; Drug Therapy, Combination; HIV Infections; Humans; Hydroxyurea; Lamivudine	2004
Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein. Biochemical pharmacology, 2016, Mar-01, Volume: 103 Topics: Animals; Antiviral Agents; Cell Line, Tumor; DNA Replication; DNA, Circular; DNA, Viral; Drug Resistance, Viral; Drug Synergism; Genome, Viral; Hepatitis B virus; Humans; Hydroxyurea; Lamivudine; Liver; Mice; Mutation; Ribonucleoside Diphosphate Reductase; Salicylanilides; Virus Replication	2016