hydroxyurea has been researched along with l 663536 in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (72.73) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Desai, SN; Jamieson-Leclercq, T; Noonan, TC | 1 |
| Henson, PM; Hill, E; Maclouf, J; Murphy, RC | 1 |
| Bailie, MB; Carter, GW; Dahm, LJ; Harris, RR; Peters-Golden, M; Roth, RA | 1 |
| Ford-Hutchinson, AW | 1 |
| Carpenter, TG; Cuthbert, NJ; Fitzgerald, MF; Francis, HP; Gardiner, PJ; Mohrs, K; Müller-Peddinghaus, R; Newton, BB; Patel, UP; Thompson, AM | 1 |
| Guidot, DM; Repine, JE; Repine, MJ; Westcott, JY | 1 |
| Black, C; Brideau, C; Chan, C; Ford-Hutchinson, A; Frenette, R; Tagari, P | 1 |
| Frossard, N; LeGall, G; Poaty, V; Riquet, M | 1 |
| Chertock, H; DiPasquale, G; Koeler, J; Peppard, J; Raychaudhuri, A; White, WD | 1 |
| Howell, RE; Jenkins, LP; Rubin, EB; Sickels, BD; Weichman, BM; Woeppel, SL | 1 |
| Berkenkopf, JW; Carlson, RP; Grimes, D; Kreft, AF; Marinari, LR; Musser, JH; Sturm, RJ; Weichman, BM | 1 |
| Berkenkopf, JW; Grimes, D; Heaslip, RJ; Ilsemann, BA; Sickels, BD; Weichman, BM | 1 |
| Rainsford, KD; Smith, F; Ying, C | 1 |
| Aoki, Y; Kao, PN; Qiu, D; Zhao, GH | 1 |
| Castonguay, A; Rioux, N | 1 |
| Carlson, R; Glaser, K; Hartman, D; Kreft, A; Lock, Y; Tomchek, L; Weichman, B | 1 |
| Gunning, WT; Kramer, PM; Pereira, MA; Steele, VE | 1 |
| Aronoff, DM; Canetti, C; Chen, GH; Choe, M; Flamand, N; Peters-Golden, M; Toews, GB; Wettlaufer, S | 1 |
| Andoh, T; Kamimura, K; Kawai, S; Kuraishi, Y; Nakano, T; Nojima, H; Ohtsuka, E | 1 |
| Chen, Z; Fang, SH; Huang, XJ; Li, CT; Lu, YB; Qi, LL; Wei, EQ; Yuan, YM; Zhang, L; Zhang, LH; Zhang, WP | 1 |
| Adesina, SE; Hart, CM; Kang, BY; Murphy, TC; Porter, KM; Sutliff, RL | 1 |
| Ahmadieh, H; Hafezi-Moghadam, A; Ishibashi, T; Ishikawa, K; Kanavi, MR; Koga, T; Nakama, T; Nakao, S; Ohba, M; Okuno, T; Penninger, JM; Saeki, K; Sasaki, F; Sonoda, KH; Yokomizo, T; Yoshida, S | 1 |
1 review(s) available for hydroxyurea and l 663536
| Article | Year |
|---|---|
Leukotriene antagonists and inhibitors: clinical applications.
Topics: Animals; Asthma; Glomerulonephritis; Humans; Hydroxyurea; Indoles; Inflammatory Bowel Diseases; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Propionates; Psoriasis; Quinolines; Receptors, Leukotriene | 1995 |
21 other study(ies) available for hydroxyurea and l 663536
| Article | Year |
|---|---|
Effect of BI-L-239, A-64077 and MK-886 on leukotriene B4 synthesis by chopped guinea pig lung and on antigen-induced tracheal contraction in vitro.
Topics: Animals; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phenols; Trachea | 1992 |
Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Cell Compartmentation; Cell Membrane; Cytosol; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; In Vitro Techniques; Indoles; Leukotrienes; Neutrophils; Substrate Specificity | 1992 |
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Hydroxyurea; Indoles; Inflammation; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Liver; Liver Diseases; Male; Phenyl Ethers; Rats; Rats, Sprague-Dawley | 1995 |
Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005.
Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Animals; Benzoquinones; Bronchoconstriction; Carrier Proteins; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Injections, Intravenous; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Membrane Proteins; Ovalbumin; Pyrans; Quinolines; Quinolones; Trachea | 1994 |
Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Adhesion; Chemotaxis, Leukocyte; Cytochrome c Group; Dose-Response Relationship, Drug; Humans; Hydroxyurea; In Vitro Techniques; Indoles; Interleukin-8; Kinetics; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
Topics: Animals; Calcimycin; Chromatography, High Pressure Liquid; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Quinolines | 1993 |
Effect of 5-lipoxygenase inhibitors on the anti-IgE-induced contraction of passively sensitized human bronchus in vitro.
Topics: Antibodies, Anti-Idiotypic; Bronchoconstriction; Humans; Hydroxyurea; Immunoglobulin E; In Vitro Techniques; Indoles; Leukotrienes; Lipoxygenase Inhibitors; Pyrilamine | 1993 |
Effect of 5-lipoxygenase inhibitors on in situ LTB4 biosynthesis following calcium ionophore stimulation in the rat pleural cavity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Carrageenan; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Pleura; Radioimmunoassay; Rats | 1993 |
Leukotrienes mediate antigen-induced airway hyper-reactivity in guinea pigs.
Topics: Acetophenones; Animals; Antigens; Bronchoconstriction; Eosinophilia; Guinea Pigs; Hydroxyurea; Indoles; Leukotriene D4; Leukotrienes; Lipoxygenase Inhibitors; Male; Naphthaleneacetic Acids; Quinolines; Tetrazoles | 1994 |
WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity.
Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Female; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Naphthaleneacetic Acids; Prostaglandin-Endoperoxide Synthases; Quinolines; Rabbits; Rats; Rats, Wistar | 1993 |
Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.
Topics: Acetophenones; Animals; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Naphthaleneacetic Acids; Quinolines; SRS-A; Tetrazoles; Trachea | 1993 |
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
Topics: Animals; Benzofurans; Enzyme-Linked Immunosorbent Assay; Hip Joint; Humans; Hydroxyurea; Indoles; Interleukin-1; Knee Joint; Lipoxygenase Inhibitors; Naphthalenes; Organ Culture Techniques; Oxindoles; Pyrazoles; Quinolines; Structure-Activity Relationship; Swine; Synovial Membrane; Tarsus, Animal; Thiazoles; Thiophenes | 1996 |
Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells.
Topics: Bronchi; Cell Line; Cell Line, Transformed; Epithelial Cells; Histamine; Humans; Hydroxyurea; Indoles; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; NF-kappa B; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Quinolines; RNA, Messenger; Transfection | 1998 |
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Aspirin; Body Weight; Carcinogens; Drug Screening Assays, Antitumor; Female; Hydroxyurea; Indoles; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines | 1998 |
WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood.
Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Eicosanoids; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Naphthaleneacetic Acids; Neutrophils; Quinolines; Rats; Serum Albumin | 1999 |
Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Dose-Response Relationship, Drug; Female; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred A; Phenylcarbamates; Sulfonamides; Tosyl Compounds; Urethane | 2002 |
Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages.
Topics: Animals; Antigen Presentation; Bone Marrow Cells; Calcium Signaling; Cells, Cultured; Dendritic Cells; Endocytosis; Enzyme Activation; Erythrocytes; Hydroxyurea; Immunoglobulin G; Indoles; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophages; Macrophages, Alveolar; Macrophages, Peritoneal; Mice; Mice, Inbred CBA; Mice, Knockout; Opsonin Proteins; Phagocytosis; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, IgG; Receptors, Leukotriene B4; Sheep; Syk Kinase | 2006 |
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
Topics: Animals; Arachidonate 5-Lipoxygenase; Betamethasone Valerate; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Chromones; Cimetidine; Culicidae; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Hydroxyurea; Hypersensitivity; Indoles; Indomethacin; Ketoprofen; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Phenylpropionates; Phospholipid Ethers; Propionates; Pruritus; Quinolines; Terfenadine | 2007 |
Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Antioxidants; Antipyrine; Arachidonate 5-Lipoxygenase; Caffeic Acids; Carrier Proteins; Cell Hypoxia; Edaravone; Enzyme Activation; Enzyme Inhibitors; Glucose; Hydrogen Peroxide; Hydroxyurea; Imidazoles; Indoles; Leukotrienes; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Membrane Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Pyridines; Rats; Reactive Oxygen Species; Transfection | 2009 |
Chronic hypoxia promotes pulmonary artery endothelial cell proliferation through H2O2-induced 5-lipoxygenase.
Topics: Arachidonate 5-Lipoxygenase; Cell Hypoxia; Cell Line; Cell Proliferation; Endothelial Cells; Humans; Hydrogen Peroxide; Hydroxyurea; Indoles; Lipoxygenase Inhibitors; Oxygen; Pulmonary Artery | 2014 |
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models.
Topics: Animals; Benzopyrans; Carboxylic Acids; Choroidal Neovascularization; Disease Models, Animal; Eye; Eye Injuries; Hydroxyurea; Indoles; Lasers; Leucine; Leukotriene B4; Macrophages; Macular Degeneration; Male; Mice; Mice, Knockout; Neovascularization, Pathologic; Receptors, Leukotriene B4; Signal Transduction | 2018 |