hydroxyurea and guanazole

hydroxyurea has been researched along with guanazole in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199010 (62.50)18.7374
1990's4 (25.00)18.2507
2000's1 (6.25)29.6817
2010's0 (0.00)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Hansch, C; Khwaja, TA; Selassie, CD1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Atkins, LM; Gale, GR; Meischen, SJ; Schwartz, P1
Lewis, WH; Wright, JA1
McClarty, G; Tipples, G1
Romagna, F; Suter, W1
Snapka, RM; Wani, MA1
Spector, T1
Hurlbert, RB; Moore, EC1
Bacon, PE; Cory, JG; Sato, A1
Cory, JG; Lasater, L; Sato, A2
Hards, RG; Wright, JA1
Dick, JE; Hards, RG; Wright, JA1
Larsen, IK; Sjöberg, BM; Thelander, L1
Alyahya, MY; Bhadra, S; Khan, S; Samuel, RE; Xu, YJ1

Reviews

1 review(s) available for hydroxyurea and guanazole

ArticleYear
The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).
    Pharmacology & therapeutics, 1985, Volume: 27, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Survival; Cells, Cultured; DNA; DNA Repair; DNA Replication; Drug Resistance; Guanazole; Histones; Humans; Hydroxyurea; In Vitro Techniques; Mutagens; Pyrazoles; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Structure-Activity Relationship; Triazoles

1985

Other Studies

15 other study(ies) available for hydroxyurea and guanazole

ArticleYear
Structure-activity relationships of antineoplastic agents in multidrug resistance.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured

1990
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Schedule-dependency assessments of ribonucleoside diphosphate reductase inhibitors when used in combination with platinum compounds plus cyclophosphamide in the treatment of advanced L1210 leukemia.
    Cancer treatment reports, 1979, Volume: 63, Issue:3

    Topics: Animals; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Guanazole; Hydroxyurea; Isoquinolines; Leukemia L1210; Mice; Platinum; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Thiosemicarbazones

1979
Ribonucleotide reductase from wild type and hydroxyurea-resistant chinese hamster ovary cells.
    Journal of cellular physiology, 1978, Volume: 97, Issue:1

    Topics: Animals; Cell Line; Cell-Free System; Cells, Cultured; Cricetinae; Drug Resistance, Microbial; Guanazole; Hybrid Cells; Hydroxyurea; Mutation; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases

1978
Isolation and initial characterization of a series of Chlamydia trachomatis isolates selected for hydroxyurea resistance by a stepwise procedure.
    Journal of bacteriology, 1991, Volume: 173, Issue:16

    Topics: Adenine; Animals; Chlamydia trachomatis; Cytidine Diphosphate; DNA, Bacterial; Drug Resistance, Microbial; Guanazole; Hydroxyurea; L Cells; Mutation; Ribonucleotide Reductases; Selection, Genetic

1991
DNA repair induced by various mutagens in rat hepatocyte primary cultures measured in the presence of hydroxyurea, guanazole or aphidicolin.
    Mutation research, 1990, Volume: 231, Issue:2

    Topics: Animals; Aphidicolin; Cells, Cultured; Diterpenes; DNA Damage; DNA Repair; Guanazole; Hydroxyurea; Liver; Male; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Triazoles; Ultraviolet Rays

1990
Drug-induced loss of unstably amplified genes.
    Cancer investigation, 1990, Volume: 8, Issue:6

    Topics: Camptothecin; Dose-Response Relationship, Drug; Drug Resistance; Eflornithine; Gene Amplification; Guanazole; Hydroxyurea; Methotrexate; Proflavine; Tetrahydrofolate Dehydrogenase

1990
Inhibition of ribonucleotide reductases encoded by herpes simplex viruses.
    Pharmacology & therapeutics, 1985, Volume: 31, Issue:3

    Topics: Acyclovir; Antiviral Agents; Guanazole; Herpes Simplex; Humans; Hydroxyurea; Nucleotides; Pyridoxal Phosphate; Ribonucleotide Reductases; Simplexvirus

1985
Studies on the differential mechanisms of inhibition of ribonucleotide reductase by specific inhibitors of the non-heme iron subunit.
    Advances in enzyme regulation, 1984, Volume: 22

    Topics: Anaerobiosis; Animals; Catalase; Cell Division; Cells, Cultured; Deferoxamine; Guanazole; Humans; Hydroxyurea; Isoenzymes; Isoquinolines; Leukemia L1210; Peroxidase; Peroxidases; Pyrazoles; Quinolines; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Triazoles

1984
Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.
    Biochemical pharmacology, 1981, May-01, Volume: 30, Issue:9

    Topics: Animals; Carcinoma, Ehrlich Tumor; Chelating Agents; Deferoxamine; Edetic Acid; Female; Guanazole; Hydroxyurea; Iron Chelating Agents; Mice; Mice, Inbred ICR; Oxyquinoline; Ribonucleotide Reductases

1981
N-carbamoyloxyurea-resistant Chinese hamster ovary cells with elevated levels of ribonucleotide reductase activity.
    Journal of cellular physiology, 1981, Volume: 106, Issue:2

    Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Deoxyadenine Nucleotides; Drug Resistance; Female; Guanazole; Hydroxyurea; Kinetics; Ovary; Ribonucleotide Reductases; Substrate Specificity

1981
Studies of mammalian ribonucleotide reductase activity in intact permeabilized cells: a genetic approach.
    Advances in enzyme regulation, 1980, Volume: 19

    Topics: Animals; Cell Line; Cell Membrane Permeability; Cricetinae; Cricetulus; Drug Resistance; Guanazole; Humans; Hydroxyurea; Kinetics; L Cells; Mice; Mutation; Ribonucleotide Reductases

1980
Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy.
    Advances in enzyme regulation, 1980, Volume: 19

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Interactions; Drug Synergism; Female; Guanazole; Hydroxyurea; Iron Chelating Agents; Isoquinolines; Mice; Pyrazoles; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Thiosemicarbazones

1980
Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues.
    European journal of biochemistry, 1982, Jun-15, Volume: 125, Issue:1

    Topics: Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Escherichia coli; Fibroblasts; Guanazole; Hydroxyurea; In Vitro Techniques; Mice; Nitroso Compounds; Ribonucleotide Reductases; Structure-Activity Relationship; T-Phages; Thymus Gland

1982
Replication stress induced by the ribonucleotide reductase inhibitor guanazole, triapine and gemcitabine in fission yeast.
    FEMS yeast research, 2022, 03-24, Volume: 22, Issue:1

    Topics: Cell Cycle Proteins; Checkpoint Kinase 2; Deoxycytidine; DNA Replication; Enzyme Inhibitors; Gemcitabine; Guanazole; Humans; Hydroxyurea; Pyridines; Ribonucleotide Reductases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Thiosemicarbazones

2022