hydroxyurea and carbostyril

hydroxyurea has been researched along with carbostyril in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (46.67)18.2507
2000's6 (40.00)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER1
Carpenter, TG; Cuthbert, NJ; Fitzgerald, MF; Francis, HP; Gardiner, PJ; Mohrs, K; Müller-Peddinghaus, R; Newton, BB; Patel, UP; Thompson, AM1
Currie, JL; Isakson, PC; Rao, TS; Shaffer, AF1
Currie, JL; Isakson, PC; Kim, S; Rao, T; Shaffer, AF; Smith, WG; Thompson, JM1
Payne, AN; Price, RC; Yeadon, M1
Andresen, CJ; Eggler, JF; Smith, WB; Turner, CR; Watson, JW1
Furihata, C; Katsumura, Y; Kobayashi, H; Mori, M; Sugiyama, C1
Henriques, JA; Pereira, VR; Saffi, J1
Alcaraz, MJ; Guillén, MI; Vicente, AM1
Amacher, DE; Beierschmitt, WP; Griffiths, RJ; McNeish, JD; Nagahisa, A; Nakane, M1
Dahm, K; Hübscher, U1
Buscemi, G; Canevari, S; Carlessi, L; Delia, D; Fontanella, E; Lisanti, S; Zannini, L1
Alexeeva, JA; Bessems, A; Beutel, G; Bordessoule, D; Brandwein, JM; Burnett, AK; De Porre, P; Dombret, H; Golenkov, AK; Harousseau, JL; Howes, AJ; Jedrzejczak, WW; Khuageva, NK; Maertens, J; Martinelli, G; Masszi, T; Mollgard, L; Ossenkoppele, GJ; Park, YC; Robak, T; Thomas, X; Tothova, E; Vidriales, MB1
Aström, SU; Barsoum, E; Chabes, A; Tsaponina, O1
Choi, JE; Chung, WH; Heo, SH; Kim, MJ1

Trials

1 trial(s) available for hydroxyurea and carbostyril

ArticleYear
A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older.
    Blood, 2009, Aug-06, Volume: 114, Issue:6

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Disease-Free Survival; Female; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Male; Neutropenia; Quinolones; Survival Rate; Time Factors

2009

Other Studies

14 other study(ies) available for hydroxyurea and carbostyril

ArticleYear
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2

1992
Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005.
    European journal of pharmacology, 1994, Jun-02, Volume: 258, Issue:1-2

    Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Animals; Benzoquinones; Bronchoconstriction; Carrier Proteins; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Injections, Intravenous; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Membrane Proteins; Ovalbumin; Pyrans; Quinolines; Quinolones; Trachea

1994
Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat.
    Life sciences, 1993, Volume: 53, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Disease Models, Animal; Drug Evaluation, Preclinical; Eicosanoids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley

1993
Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3

    Topics: Animals; Antigens; Blood Vessels; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Guinea Pigs; Humans; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Rats; Skin

1995
Allergen-induced glycoconjugate secretion in guinea-pig trachea in vivo: modulation by indomethacin, BW B70C and ZD-2138.
    Pulmonary pharmacology, 1995, Volume: 8, Issue:1

    Topics: Acetylcholine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Glycoconjugates; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Hydroxylamines; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Methylurea Compounds; Pyrans; Quinolones; Spectrometry, Fluorescence; Trachea

1995
The effect of 5-lipoxygenase inhibition on Ascaris antigen (Ag)-induced responses in atopic monkeys.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Helminth; Ascaris suum; Bronchoalveolar Lavage Fluid; Hydroxyurea; Inflammation; Leukocyte Count; Lipoxygenase Inhibitors; Macaca fascicularis; Male; Neutrophils; Pyrans; Quinolones

1996
Induction of unscheduled DNA synthesis in hairless mouse epidermis by skin carcinogens.
    The Journal of toxicological sciences, 1999, Volume: 24, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; DNA; DNA Damage; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Hydroxyurea; Methylnitronitrosoguanidine; Mice; Mice, Hairless; Quinolones; Skin

1999
Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae.
    Current genetics, 2000, Volume: 37, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Cell Division; DNA Helicases; DNA Repair; Hydrogen Peroxide; Hydroxyurea; Mechlorethamine; Methyl Methanesulfonate; Mutagens; Mutation; Quinolones; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ultraviolet Rays

2000
Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages.
    British journal of pharmacology, 2001, Volume: 133, Issue:6

    Topics: Amidines; Animals; Benzylamines; Cell Line; Chick Embryo; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxyurea; Indomethacin; Isoenzymes; Leukotriene B4; Leukotriene C4; Leukotrienes; Macrophage Activation; Macrophages; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrans; Quinolones; Sulfonamides; Time Factors; Transcription Factor AP-1; Zymosan

2001
Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 63, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hydroxyurea; Lipoxygenase Inhibitors; Liver; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Microsomes, Liver; NADH Dehydrogenase; Organ Size; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley

2001
Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block.
    Oncogene, 2002, Oct-31, Volume: 21, Issue:50

    Topics: 4-Nitroquinoline-1-oxide; Cell Cycle; Cell Cycle Proteins; Cell Nucleus; DNA Replication; DNA-Binding Proteins; HeLa Cells; Humans; Hydroxyurea; Proliferating Cell Nuclear Antigen; Quinolones; Replication Protein C; S Phase

2002
DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues.
    Molecular and cellular biology, 2006, Volume: 26, Issue:21

    Topics: 4-Nitroquinoline-1-oxide; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Hydroxyurea; Multiprotein Complexes; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Quinolones; Radiation, Ionizing; Recombinant Fusion Proteins; RNA Interference; Serine; Tumor Suppressor Proteins

2006
Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.
    PLoS genetics, 2011, Volume: 7, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Amino Acid Sequence; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Gene Order; High Mobility Group Proteins; Histones; Hydroxyurea; Molecular Sequence Data; Mutation; Nucleic Acid Synthesis Inhibitors; Phenotype; Protein Serine-Threonine Kinases; Quinolones; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Transcription, Genetic

2011
Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae.
    Free radical biology & medicine, 2018, Volume: 129

    Topics: 4-Nitroquinoline-1-oxide; DNA Breaks, Double-Stranded; DNA, Fungal; Gene Expression Regulation, Fungal; Genome, Fungal; Genomic Instability; Homologous Recombination; Hydrogen Peroxide; Hydroxyurea; Methyl Methanesulfonate; Molecular Chaperones; Mutation; Paraquat; Phleomycins; Quinolones; Rad51 Recombinase; Reactive Oxygen Species; Recombinational DNA Repair; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Superoxide Dismutase-1

2018