hydroxyurea has been researched along with calcimycin in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (80.77) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Greco, MN; Hageman, WE; Persico, FJ; Powell, ET; Tighe, JJ | 1 |
| Abraham, WM; Ahmed, A; Bell, RL; Bouska, J; Cortes, A; Hinz, W; Lanni, C; Sielczak, MW | 1 |
| Henson, PM; Hill, E; Maclouf, J; Murphy, RC | 1 |
| Borgeat, P; Dubé, L; Kesterson, J; Lauzière, M; Rubin, P; Sirois, P | 1 |
| Bustelo, XR; Freire, M; Gómez-Márquez, J; Otero, A | 1 |
| Bendele, AM; Fleisch, JH; Wong, WS | 1 |
| Garland, LG; Jackson, WP; Salmon, JA | 1 |
| Dermarkarian, R; Drazen, JM; Israel, E; Rosenberg, M; Rubin, P; Sperling, R; Taylor, G | 1 |
| Bailie, MB; Carter, GW; Dahm, LJ; Harris, RR; Peters-Golden, M; Roth, RA | 1 |
| Henson, PM; Hill, E; MacMillan, D; Murphy, RC; Sala, A | 1 |
| Black, C; Brideau, C; Chan, C; Ford-Hutchinson, A; Frenette, R; Tagari, P | 1 |
| Hutchison, AJ; Kimble, EF; Kowalski, TJ; Lee, WH; Libby, AH; Satoh, Y; Stanton, JL; White, DH | 1 |
| Chertock, H; DiPasquale, G; Koeler, J; Peppard, J; Raychaudhuri, A; White, WD | 1 |
| Currie, JL; Isakson, PC; Rao, TS; Shaffer, AF | 1 |
| Currie, JL; Isakson, PC; Kim, S; Rao, T; Shaffer, AF; Smith, WG; Thompson, JM | 1 |
| Alper, SL; Beuzard, Y; Brugnara, C; de Franceschi, L; Jouault, H; Rouyer-Fessard, P | 1 |
| Bell, RL; Carter, GW; Goodfellow, C; Harris, RR; Namovic, MT; Walsh, RE | 1 |
| Bolognese, B; Marshall, LA; Roshak, A; Winkler, JD | 1 |
| Akiyama, Y; Furusho, K; Kataoka, A; Koishi, S; Kubota, M; Lin, YW; Sawada, M; Usami, I; Watanabe, Ki | 1 |
| Akiyama, Y; Furusho, K; Kataoka, A; Kitoh, T; Koishi, S; Kubota, M; Lin, YW; Sawada, M; Usami, I; Watanabe, K | 1 |
| Brock, TG; McNish, RW; Peters-Golden, M | 1 |
| Hirasawa, N; Kushihara, M; Ohuchi, K; Takahagi, H; Takasaki, W; Takayanagi, M; Yamashita, M | 1 |
| Hénichart, JP; Pommery, J; Pommery, N | 1 |
| Anderson, GD; Dufield, DR; Hardy, MM; Masferrer, JL; Pufahl, RA; Zweifel, BS | 1 |
| Dastidar, SG; Kakar, S; Paliwal, JK; Ray, A; Salman, M; Sattigeri, V; Sharma, P; Shirumalla, RK; Singh Saini, G; Varshney, B | 1 |
2 trial(s) available for hydroxyurea and calcimycin
| Article | Year |
|---|---|
Effect of Zileuton (A-64077) on the 5-lipoxygenase activity of human whole blood ex vivo.
Topics: Adolescent; Adult; Arachidonate 5-Lipoxygenase; Calcimycin; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Hydroxyurea; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Radioimmunoassay | 1991 |
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Calcimycin; Cold Temperature; Double-Blind Method; Eicosanoids; Humans; Humidity; Hydroxyurea; Lipoxygenase Inhibitors; Male | 1990 |
24 other study(ies) available for hydroxyurea and calcimycin
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.
Topics: Animals; Benzothiazoles; Calcimycin; Dogs; Humans; Hydroxamic Acids; Hydroxyurea; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Methemoglobin; Mice; Molecular Structure; Peritonitis; SRS-A; Structure-Activity Relationship; Thiazoles | 1992 |
The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep.
Topics: Administration, Oral; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Dose-Response Relationship, Drug; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Sheep | 1992 |
Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Cell Compartmentation; Cell Membrane; Cytosol; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; In Vitro Techniques; Indoles; Leukotrienes; Neutrophils; Substrate Specificity | 1992 |
Expression of the rat prothymosin alpha gene during T-lymphocyte proliferation and liver regeneration.
Topics: Animals; Blotting, Northern; Calcimycin; Cell Cycle; Gene Expression; Histones; Hydroxyurea; Liver Regeneration; Lymphocyte Activation; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; S Phase; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymosin; Time Factors | 1991 |
Pharmacologic evaluation of A23187-induced contractions of three distinct preparations of guinea pig lung parenchymal strips.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcimycin; Drug Interactions; Guinea Pigs; Histamine; Hydroxyurea; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth; Prostaglandin Endoperoxides, Synthetic; Pyrilamine; SRS-A | 1992 |
Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents.
Topics: Administration, Oral; Animals; Benzeneacetamides; Biological Availability; Biotransformation; Calcimycin; Dogs; Drug Design; Half-Life; Humans; Hydroxamic Acids; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Rabbits; Rats; Structure-Activity Relationship | 1991 |
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Hydroxyurea; Indoles; Inflammation; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Liver; Liver Diseases; Male; Phenyl Ethers; Rats; Rats, Sprague-Dawley | 1995 |
Properties of LTA4 synthase in human neutrophil preparations.
Topics: Arachidonate 5-Lipoxygenase; Calcimycin; Cell Membrane; Cytosol; Humans; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Neutrophils | 1995 |
Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
Topics: Animals; Calcimycin; Chromatography, High Pressure Liquid; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Quinolines | 1993 |
Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.
Topics: Animals; Arachidonate 5-Lipoxygenase; Calcimycin; Chromones; Cyclooxygenase Inhibitors; Dogs; Guinea Pigs; Humans; Hydroxamic Acids; Hydroxylamines; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Male; Molecular Structure; Neutrophils; Seminal Vesicles; Sheep; Structure-Activity Relationship | 1993 |
Effect of 5-lipoxygenase inhibitors on in situ LTB4 biosynthesis following calcium ionophore stimulation in the rat pleural cavity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Carrageenan; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Pleura; Radioimmunoassay; Rats | 1993 |
Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Disease Models, Animal; Drug Evaluation, Preclinical; Eicosanoids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley | 1993 |
Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.
Topics: Animals; Antigens; Blood Vessels; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Guinea Pigs; Humans; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Rats; Skin | 1995 |
Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy.
Topics: Animals; beta-Thalassemia; Body Water; Calcimycin; Calcium; Calcium Channel Blockers; Chlorides; Clotrimazole; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Erythrocyte Aging; Erythrocyte Count; Erythrocyte Deformability; Erythrocytes, Abnormal; Erythropoietin; Female; Gene Deletion; Globins; Hematocrit; Humans; Hydroxyurea; Intracellular Fluid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Potassium; Potassium Channels; Recombinant Proteins; Reticulocytes; Rubidium | 1996 |
Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Calcimycin; Dextrans; Eosinophils; Hydroxyurea; Ionophores; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pulmonary Eosinophilia; Rats; Theophylline | 1996 |
Depletion of human monocyte 85-kDa phospholipase A2 does not alter leukotriene formation.
Topics: Arachidonic Acids; Binding Sites; Calcimycin; Enzyme Inhibitors; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Molecular Weight; Monocytes; Oligonucleotides, Antisense; Phagocytosis; Phospholipases A; Phospholipases A2; Sulfonamides; Zymosan | 1997 |
Apoptosis-resistant phenotype selected by alternating exposure to camptothecin and etoposide.
Topics: Antineoplastic Agents; Apoptosis; Arabinofuranosylcytosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; bcl-X Protein; Calcimycin; Camptothecin; Clone Cells; Cycloheximide; Cytarabine; DNA Fragmentation; Drug Resistance, Neoplasm; Etoposide; HL-60 Cells; Humans; Hydroxyurea; Kinetics; Nucleosomes; Phenotype; Proto-Oncogene Proteins c-bcl-2; Ultraviolet Rays | 1997 |
NADH dehydrogenase deficiency in an apoptosis-resistant mutant isolated from a human HL-60 leukemia cell line.
Topics: Antineoplastic Agents; Apoptosis; Calcimycin; Camptothecin; Cell Division; Clone Cells; Cloning, Molecular; Cytarabine; Deoxyglucose; Etoposide; Glucose; HL-60 Cells; Humans; Hydroxyurea; Macromolecular Substances; Mitochondria; Mutagenesis; NADH Dehydrogenase; Transcription, Genetic; Ultraviolet Rays | 1997 |
Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages.
Topics: Animals; Arachidonate 5-Lipoxygenase; Biological Transport; Calcimycin; Cell Membrane; Enzyme Activation; Female; Hydroxyurea; Interphase; Leukemia, Basophilic, Acute; Leukotrienes; Lipoxygenase Inhibitors; Macrophages, Alveolar; Mast Cells; Rats; Rats, Wistar; Tumor Cells, Cultured | 1998 |
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Modification of eicosanoid profile in human blood treated by dual COX/LOX inhibitors.
Topics: Arachidonic Acid; Calcimycin; Celecoxib; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Eicosanoids; Humans; Hydroxyurea; Indomethacin; Inhibitory Concentration 50; Lipopolysaccharides; Lipoxygenase Inhibitors; Pyrazoles; Sulfonamides | 2005 |
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
Topics: Air; Animals; Arachidonate 5-Lipoxygenase; Biological Assay; Calcimycin; Carrageenan; Cell Line, Tumor; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyurea; Imidazoles; Immunoglobulin E; Inflammation; Ionophores; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Oxidation-Reduction; Rats; Rats, Inbred Lew; Reproducibility of Results; Sulfides; Tandem Mass Spectrometry | 2008 |
Pharmacodynamic and pharmacokinetic characterisation of RBx 7796: a novel 5-lipoxygenase inhibitor.
Topics: Animals; Arachidonate 5-Lipoxygenase; Bronchial Hyperreactivity; Calcimycin; Dogs; Humans; Hydroxyurea; Ionophores; Leukotriene B4; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Neutrophils; Rats; Rats, Wistar; Salts | 2008 |