Compounds > hydroxyurea

hydroxyurea and acetylcysteine

hydroxyurea has been researched along with acetylcysteine in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (8.33)	18.2507
2000's	4 (33.33)	29.6817
2010's	6 (50.00)	24.3611
2020's	1 (8.33)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Fukuchi, K; Gomi, K; Nakamaki, T; Tomoyasu, S; Tsuruoka, N	1
Bundy, RE; Chester, AH; Marczin, N; Yacoub, M	1
Chan, LC; Hu, L; Jin, DY; Kong, KY; Pan, K; Siu, KL; Sun, H; Tang, HM; Wong, CM	1
Caslin, HL; Elford, HL; Kolawole, EM; McLeod, JJA; Paranjape, A; Qayum, AA; Ryan, JJ; Spence, AJ; Taruselli, MT	1

Reviews

1 review(s) available for hydroxyurea and acetylcysteine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

11 other study(ies) available for hydroxyurea and acetylcysteine

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells. Biochimica et biophysica acta, 1998, Sep-16, Volume: 1404, Issue:3 Topics: Acetylcysteine; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Cytarabine; Deferoxamine; DNA Damage; Etoposide; Gene Expression Regulation; Hydroxyurea; Polyribosomes; RNA, Messenger; Tumor Cells, Cultured; Ubiquitins	1998
A redox-based mechanism for nitric oxide-induced inhibition of DNA synthesis in human vascular smooth muscle cells. British journal of pharmacology, 2000, Volume: 129, Issue:7 Topics: Acetylcysteine; Animals; Ascorbic Acid; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Free Radical Scavengers; G1 Phase; Glutathione; Humans; Hydroxyurea; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxidation-Reduction; Penicillamine; Rats; S Phase; S-Nitrosoglutathione	2000
Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor. Scientific reports, 2015, Jan-20, Volume: 5 Topics: Acetylcysteine; Cell Cycle; Cell Proliferation; DNA Replication; Ferredoxins; Hydroxyurea; Iron; Oxidation-Reduction; Phenotype; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors	2015
Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells. Cellular immunology, 2017, Volume: 319 Topics: Acetylcysteine; Animals; Bone Marrow Cells; Chemokine CCL3; Female; Gene Expression Regulation; Genes, Reporter; Hydroxamic Acids; Hydroxyurea; Immunosuppressive Agents; Interleukin-13; Interleukin-33; Lipopolysaccharides; Luciferases; Male; Mast Cells; Mice; Mice, Inbred C57BL; NF-kappa B; Primary Cell Culture; Signal Transduction; Transcription Factor AP-1; Tumor Necrosis Factor-alpha	2017