hydroxyurea has been researched along with 4-phenylbutyric acid in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Fibach, E; Prasanna, P; Rodgers, GP; Samid, D | 1 |
| Coates, TD; Davies, S; Kuypers, FA; Mignacca, R; Olivieri, NF; Singer, ST; Sweeters, N; Vichinsky, EP; Weatherall, DJ | 1 |
| Brun, M; Elion, J; Krishnamoorthy, R; Lapouméroulie, C; Odièvre, MH | 1 |
| Brose, RD; Dong, GX; Keefer, J; McGuinness, MC; Purvis, S; Schneidereith, T; Shin, G; Smith, KD; Spencer, F | 1 |
1 review(s) available for hydroxyurea and 4-phenylbutyric acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for hydroxyurea and 4-phenylbutyric acid
| Article | Year |
|---|---|
Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment.
Topics: beta-Thalassemia; Blood Transfusion; Combined Modality Therapy; Drug Therapy, Combination; Erythropoiesis; Erythropoietin; Facial Bones; Fetal Hemoglobin; Gene Expression; Genotype; Globins; Hematopoiesis, Extramedullary; Hemoglobin E; Humans; Hydroxyurea; Phenylbutyrates; Radiography; Recombinant Proteins; Splenectomy; Splenomegaly; Treatment Outcome | 2005 |
4 other study(ies) available for hydroxyurea and 4-phenylbutyric acid
| Article | Year |
|---|---|
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia.
Topics: Anemia, Sickle Cell; Azacitidine; beta-Thalassemia; Blotting, Northern; Butyrates; Butyric Acid; Cell Division; Cells, Cultured; DNA Probes; Erythrocytes; Fetal Hemoglobin; Hematopoietic Stem Cells; Humans; Hydroxyurea; Kinetics; Phenylacetates; Phenylbutyrates; Reference Values | 1993 |
Sodium phenyl butyrate downregulates endothelin-1 expression in cultured human endothelial cells: relevance to sickle-cell disease.
Topics: Anemia, Sickle Cell; Cell Line, Transformed; Drug Evaluation, Preclinical; Drug Synergism; Endothelial Cells; Endothelin-1; Gene Expression Regulation; Humans; Hydroxyurea; Intercellular Adhesion Molecule-1; Interferon-gamma; Phenylbutyrates; RNA, Messenger; Solubility; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2007 |
Activation of the stress proteome as a mechanism for small molecule therapeutics.
Topics: Adrenoleukodystrophy; Cell Line; Drug Therapy; Humans; Hydroxamic Acids; Hydroxyurea; Isothiocyanates; Mitochondrial Turnover; Phenylbutyrates; Proteome; Small Molecule Libraries; Sulfoxides; Thiocyanates | 2012 |