Compounds > hydroxyurea

hydroxyurea and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone

hydroxyurea has been researched along with 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Basu, A; Hu, S; Jayaprakash, V; Krishnan, K; Mishra, N; Prathiba, K; Yen, Y; Zhou, B1
Cory, AH; Cory, JG; Finch, RA; Liu, MC; Sartorelli, AC1
Cheng, Y; Finch, RA; Grill, SP; Liu, M; Loomis, R; Rose, WC; Sartorelli, AC; Vasquez, KM1
Belcourt, MF; Cory, JG; Lin, ZP; Sartorelli, AC1
Barry, BA; Lieberman, RL; Offenbacher, AR; Safiarian, MS; Watson, RA1
Alyahya, MY; Bhadra, S; Khan, S; Samuel, RE; Xu, YJ1

Reviews

1 review(s) available for hydroxyurea and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone

ArticleYear
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.
    Advances in enzyme regulation, 1999, Volume: 39

    Topics: Animals; Antineoplastic Agents; Cell Division; DNA, Neoplasm; Drug Resistance; Enzyme Inhibitors; Female; Hydroxyurea; In Vitro Techniques; Iron; Leukemia L1210; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Pyridines; Ribonucleotide Reductases; Thiosemicarbazones; Tumor Cells, Cultured

1999

Other Studies

5 other study(ies) available for hydroxyurea and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone

ArticleYear
Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones.
    Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23

    Topics: Humans; Hydroxyurea; Molecular Structure; Oxidation-Reduction; Protein Subunits; Ribonucleotide Reductases; Thiosemicarbazones

2008
Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.
    Biochemical pharmacology, 2000, Apr-15, Volume: 59, Issue:8

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Cell Division; DNA; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Hydroxyurea; KB Cells; Leukemia L1210; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyridines; Ribonucleotide Reductases; Thiosemicarbazones; Tumor Cells, Cultured

2000
Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors.
    The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Deoxyribonucleotides; DNA Damage; Down-Regulation; Doxorubicin; Enzyme Inhibitors; Etoposide; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Protein Subunits; Proto-Oncogene Proteins; Pyridines; Recombinant Proteins; Ribonucleotide Reductases; RNA, Small Interfering; Thiosemicarbazones; Tumor Suppressor Protein p53; Vincristine

2004
    The journal of physical chemistry letters, 2021, Sep-23, Volume: 12, Issue:37

    Topics: Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Ferrous Compounds; Free Radicals; Hydroxyurea; Protein Binding; Protein Subunits; Pyridines; Ribonucleotide Reductases; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thiosemicarbazones

2021
Replication stress induced by the ribonucleotide reductase inhibitor guanazole, triapine and gemcitabine in fission yeast.
    FEMS yeast research, 2022, 03-24, Volume: 22, Issue:1

    Topics: Cell Cycle Proteins; Checkpoint Kinase 2; Deoxycytidine; DNA Replication; Enzyme Inhibitors; Gemcitabine; Guanazole; Humans; Hydroxyurea; Pyridines; Ribonucleotide Reductases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Thiosemicarbazones

2022