hydroxytyrosyl-acetate and oleuropein

hydroxytyrosyl-acetate has been researched along with oleuropein* in 2 studies

Other Studies

2 other study(ies) available for hydroxytyrosyl-acetate and oleuropein

ArticleYear
Chemical characterization of liposomes containing nutraceutical compounds: Tyrosol, hydroxytyrosol and oleuropein.
    Biophysical chemistry, 2019, Volume: 246

    Tyrosol, hydroxytyrosol and oleuropein are among the major phenolic compounds in fruits, leaves and oils from Olea europaea L. These natural antioxidants molecules revealed several beneficial effects on human health, but a low bioavailability and accessibility to targeted site. Liposomes are drug/nutraceutical delivery carriers, used for driving bioactive molecules to desired target tissues, decreasing potential side effects and protecting the encapsulated molecule from enzymatic metabolic processes. In this study, zwitterionic liposomes containing tyrosol, hydroxytyrosol and oleuropein were synthesized and characterized for their size and surface charge. Particular attention was devoted to the determination of encapsulation efficiency (EE%), quantifying the loaded Tyr, HTyr and Ole amount, by using three different techniques: direct UV spectrophotometry, High Performance Liquid Chromatography and Trolox Equivalent Antioxidant Capacity assay. The results revealed higher EE% for oleuropein. Cyto-toxicity and cyto-compatibility of liposomes were also tested on human chondrocyte cells.

    Topics: Acetates; Antioxidants; Catechols; Cells, Cultured; Chondrocytes; Dietary Supplements; Drug Delivery Systems; Humans; Iridoid Glucosides; Iridoids; Liposomes; Olea; Phenylethyl Alcohol

2019
Faecal microbial metabolism of olive oil phenolic compounds: in vitro and in vivo approaches.
    Molecular nutrition & food research, 2014, Volume: 58, Issue:9

    In the present study, the individual colonic metabolism of the main components of the virgin olive oil phenolic fraction was evaluated by an in vitro model using human faecal microbiota. To assess differences in metabolism related to the molecular structure, four phenolic standards were selected, tyrosol, hydroxytyrosol, hydroxytyrosol acetate and oleuropein. After studying the in vitro colonic metabolism pathways of the individual phenols, the presence of their colonic metabolites was investigated in human faecal samples obtained before and after the sustained intake (3 weeks) of a daily dose of 25 mL of a phenol-enriched olive oil.. The in vitro colon fermentation of the four individual phenolic compounds revealed (i) an increase in phenolic acids, (ii) the stability of hydroxytyrosol and tyrosol and (iii) the high degradation of hydroxytyrosol acetate and oleuropein. Additionally, a moderate intake of a phenol-rich olive oil raised the concentration in human faeces of free hydroxytyrosol and phenylacetic and phenylpropionic acids.. The products of colonic catabolism of olive oil phenolic compounds could be good candidates for novel preventive strategies and open a promising line of research into the preventive action of olive oil phenols in colon and other bowel diseases.

    Topics: Acetates; Catechols; Colon; Feces; Fermentation; Humans; In Vitro Techniques; Iridoid Glucosides; Iridoids; Kinetics; Microbiota; Nontherapeutic Human Experimentation; Olive Oil; Phenols; Phenylethyl Alcohol; Plant Oils

2014