Page last updated: 2024-09-04

hydroxytriamterene sulfate ester and triamterene

hydroxytriamterene sulfate ester has been researched along with triamterene in 13 studies

Compound Research Comparison

Studies
(hydroxytriamterene sulfate ester)
Trials
(hydroxytriamterene sulfate ester)
Recent Studies (post-2010)
(hydroxytriamterene sulfate ester)
Studies
(triamterene)
Trials
(triamterene)
Recent Studies (post-2010) (triamterene)
14101,21218186

Protein Interaction Comparison

ProteinTaxonomyhydroxytriamterene sulfate ester (IC50)triamterene (IC50)
Janus kinase 2 (a protein tyrosine kinase)Homo sapiens (human)4.613
Cathepsin GHomo sapiens (human)7.413
Cytochrome P450 2D6Homo sapiens (human)10
Caspase-1Homo sapiens (human)3.663

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19908 (61.54)18.7374
1990's3 (23.08)18.2507
2000's2 (15.38)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Völger, KD1
Bochner, F; Lloyd, C; Muirhead, MR; Somogyi, AA1
Dao, MT; Villeneuve, JP1
Benet, LZ; Blume, C; Clark, TS; Lin, E; Thornhill, MD; Upton, RA; Williams, RL1
Benet, LZ; Ettinger, B; Sörgel, F1
Greeff, K; Noack, EA; Schuhmacher, P1
Gilfrich, HJ; Knauf, H; Möhrke, W; Mutschler, E; Völger, KD1
Nancollas, GH; White, DJ1
Knauf, H; Leilich, G; Mutschler, E; Völger, KD1
Busch, AE; Greger, R; Hipper, A; Kunzelmann, K; Lang, F; Lindemann, B; Mutschler, E; Suessbrich, H; Waldegger, S1
Knauf, H; Möhrke, W; Mutschler, E1
Blaschke, G; Horstkötter, C; Kober, S; Mutschler, E; Spahn-Langguth, H1
de Koning, CB; Fernandes, MA; Govender, S; Pelly, SC; Schmalz, HG1

Trials

1 trial(s) available for hydroxytriamterene sulfate ester and triamterene

ArticleYear
Pharmacokinetics and pharmacodynamics of triamterene and hydrochlorothiazide and their combination in healthy volunteers.
    International journal of clinical pharmacology and therapeutics, 1997, Volume: 35, Issue:10

    Topics: Adult; Antihypertensive Agents; Cross-Over Studies; Diuretics; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Female; Humans; Hydrochlorothiazide; Kidney Tubules; Linear Models; Male; Sodium; Triamterene

1997

Other Studies

12 other study(ies) available for hydroxytriamterene sulfate ester and triamterene

ArticleYear
[Animal experimental and human pharmacologic studies with phase-II metabolites of triamterene].
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:5

    Topics: Adult; Diuretics; Female; Furosemide; Heart; Humans; Injections, Intravenous; Kidney; Male; Sodium; Triamterene

1991
Deconjugation of p-hydroxytriamterene sulphate in the rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1989, Volume: 19, Issue:6

    Topics: Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Feces; Hydrolysis; Injections, Intraperitoneal; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Triamterene

1989
Kinetics and dynamics of triamterene at steady-state in patients with cirrhosis.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1988, Volume: 11, Issue:1

    Topics: Adult; Diuresis; Drug Therapy, Combination; Female; Furosemide; Humans; Liver Cirrhosis; Male; Middle Aged; Natriuresis; Potassium; Sodium; Triamterene

1988
Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function.
    Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:2

    Topics: Absorption; Adult; Aged; Aging; Biological Availability; Creatinine; Humans; Hydrochlorothiazide; Hypertension; Kidney; Kinetics; Middle Aged; Triamterene

1986
The true composition of kidney stones passed during triamterene therapy.
    The Journal of urology, 1985, Volume: 134, Issue:5

    Topics: Chromatography, Thin Layer; Humans; Kidney Calculi; Triamterene

1985
The effect of triamterene on myocardial phosphodiesterase and adenylate cyclase.
    European journal of pharmacology, 1983, Nov-11, Volume: 95, Issue:1-2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Guinea Pigs; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Triamterene

1983
Pharmacokinetics of triamterene.
    Clinical and experimental hypertension. Part A, Theory and practice, 1983, Volume: 5, Issue:2

    Topics: Age Factors; Aged; Biological Availability; Female; Humans; In Vitro Techniques; Kidney Diseases; Kinetics; Liver Diseases; Time Factors; Triamterene

1983
Triamterene and renal stone formation.
    The Journal of urology, 1982, Volume: 127, Issue:3

    Topics: Calcium Oxalate; Chemical Precipitation; Crystallization; Humans; In Vitro Techniques; Kidney Calculi; Microscopy, Electron, Scanning; Triamterene

1982
Influence of triamterene and hydroxytriamterene sulfuric acid ester on diuresis and saluresis in rats after oral and intravenous application.
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:6

    Topics: Administration, Oral; Animals; Biological Availability; Diuresis; Drug Interactions; Female; Furosemide; Injections, Intravenous; Natriuresis; Potassium; Rats; Triamterene

1980
Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis.
    Pflugers Archiv : European journal of physiology, 1996, Volume: 432, Issue:5

    Topics: Amiloride; Animals; Diuretics; Epithelium; Hydrogen-Ion Concentration; Mathematics; Membrane Potentials; Rats; Sodium Channel Blockers; Triamterene; Xenopus laevis

1996
Determination of triamterene and its main metabolite hydroxytriamterene sulfate in human urine by capillary electrophoresis using ultraviolet absorbance and laser-induced fluorescence detection.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Mar-25, Volume: 769, Issue:1

    Topics: Diuretics; Electrophoresis, Capillary; Humans; Lasers; Reproducibility of Results; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Triamterene

2002
Stereoselective syntheses of the 2-Isopropenyl-2,3-dihydrobenzofuran nucleus: potential chiral building blocks for the syntheses of tremetone, hydroxytremetone, and rotenone.
    The Journal of organic chemistry, 2007, Apr-13, Volume: 72, Issue:8

    Topics: Benzofurans; Molecular Structure; Plant Extracts; Rotenone; Stereoisomerism; Triamterene

2007