hydroxyphenytoin has been researched along with phenytoin in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (45.78) | 18.7374 |
| 1990's | 23 (27.71) | 18.2507 |
| 2000's | 18 (21.69) | 29.6817 |
| 2010's | 2 (2.41) | 24.3611 |
| 2020's | 2 (2.41) | 2.80 |
| Authors | Studies |
|---|---|
| Bius, DL; Boyles, LW; Dudley, KH; Teague, BL; Wiese, LS; Witkin, KM | 1 |
| Kabra, PM; Marton, LJ | 1 |
| Elander, M; Garle, M; Hoppel, C | 1 |
| Liu, D; Zeng, J; Zou, Y | 1 |
| Dickinson, RG; Eadie, MJ; Hooper, WD; Lander, CM; McKinnon, GE | 1 |
| Hsieh, CY; Huang, JD | 1 |
| Altieri, LP; Kirshner, M; Perel, JM; Pollock, BG; Reynolds, CF; Yeager, AL | 1 |
| Inaba, T | 1 |
| el-Din, MK; el-Emam, AA; Moustafa, MA; Subbagh, HI | 1 |
| Ito, Y; Iwaki, M; Ogiso, T; Tsunekawa, K | 1 |
| Baars, AM; Hekster, YA; Steegers-Theunissen, RP; Vree, TB | 1 |
| Anderson, WT; Lewis, LM; Oliver, SR; Shrewsbury, RP; White, LG | 1 |
| Dickinson, RG; Fowler, DW; Kluck, RM | 1 |
| Brown, LP; Flint, OP; Gibson, GG; Lewis, DF; Orton, TC | 1 |
| Barale, R; Barcellona, PS; Campana, A; Caranti, S; Rossi, V; Zucconi, D | 1 |
| Boucher, BA; Fabian, TC; Jaresko, GS; Rasmussen, SN; Rodman, JH; Watridge, CB | 1 |
| Finkler, AE; Siff, KS | 1 |
| Hinrichs, JE; Smith, QT | 1 |
| Lum, JT; Wells, PG | 1 |
| Maguire, JH; McClanahan, JS | 1 |
| Gugler, R; Jensen, JC | 1 |
| Sato, A; Shimada, K; Wakabayashi, H | 1 |
| Dickinson, RG; Eadie, MJ; Hooper, WD; Maguire, B; Patterson, M | 1 |
| Bourgeois, BF; Wad, N | 1 |
| Lascelles, PT; Patsalos, PN | 1 |
| Matzke, GR; Sawchuk, RJ | 1 |
| Izumo, Y; Murakami, N; Okabayashi, I; Sakaguchi, T; Sato, A; Shimada, K | 1 |
| Cooper, CG; Hassell, TM; Johnson, PT; Maguire, JH | 1 |
| Kapetanovic, IM; Kupferberg, HJ | 1 |
| Jürgens, U | 1 |
| Bagwell, CB; Chapman, JR; Hudson, JL; Roberts, DW; Schol, HM | 1 |
| DeVane, CL; Stout, SA | 1 |
| May, T; Rambeck, B | 1 |
| O'Leary, TD; Sansom, LN | 1 |
| Izumo, Y; Sakaguchi, T; Sato, A; Shimada, K | 1 |
| Breimer, DD; Buruma, OJ; de Wolff, FA; Ferrari, MD; Vermeij, P | 1 |
| Hassell, TM; Page, RC; Roebuck, S; Wray, SH | 1 |
| Biemann, K; Biller, JE; Browne, TR; Costello, CE; Van Langenhove, A | 1 |
| Arboix, M; Pantarotto, C; Raimondi, A; Sezzano, P | 1 |
| Dodson, WE; Loney, LC | 1 |
| Montgomery, C; Vore, M | 1 |
| Sakaguchi, T; Sato, A; Shimada, K | 1 |
| Chou, RC; Levy, G | 1 |
| Batt, AM; Engasser, JM; Magdalou, J; Sarhan, F; Siest, G | 1 |
| Cartier, LL; Sawchuk, RJ | 1 |
| Emery, MG; Kochenour, NK; Sawchuk, RJ | 1 |
| Anglin, DL; Cox, S; Jones, PR; Nahata, MC; O'Mara, NB | 1 |
| Apseloff, G; Davis, WB; Gerber, N; Mays, DC; Pawluk, LJ; Sagone, AL; She, ZW | 1 |
| Desiderio, C; Fanali, S; Küpfer, A; Thormann, W | 1 |
| Andurén, I; Brunius, G; Iinuma, M; Lerner, UH; Modéer, T | 1 |
| Brunius, G; Modéer, T; Shinoda, K; Yucel-Lindberg, T | 1 |
| Goto, W; Higuchi, S; Hirata, K; Ieiri, I; Imayama, S; Ohtsubo, K; Ohyama, Y; Toshitani, A; Yamada, H | 1 |
| Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA | 2 |
| Inubushi, M; Misawa, S; Sakamoto, N; Tanaka, E | 1 |
| Birkett, DJ; Miners, JO; Pass, MC; Tassaneeyakul, W | 1 |
| Amamoto, T; Higuchi, S; Ieiri, I; Irie, S; Kimura, M; Kubota, T; Mamiya, K; Nakamura, K; Nakano, S; Tashiro, N; Urae, A; Wada, Y; Yoshioka, S | 1 |
| Datta, P | 1 |
| Bouckaert, A; Desager, JP; Horsmans, Y; Van den Berge, V | 1 |
| Chen, LS; Goldstein, JA; Kato, R; Li, QH; Tsuzuki, T; Ueda, M; Yamazoe, Y; Yasumori, T | 1 |
| Fukumaki, Y; Furuumi, H; Higuchi, S; Ieiri, I; Imai, J; Mamiya, K; Miyahara, S; Nanba, E; Ninomiya, H; Otsubo, K; Tashiro, N; Yamane, M | 1 |
| Mayanagi, H; Onodera, K; Shinoda, H; Takahashi, A | 1 |
| Yao, TW; Zeng, S | 1 |
| Caraco, Y; Muszkat, M; Wood, AJ | 1 |
| Kim, HS; Lee, DC; Oh, KH; Park, JH | 1 |
| Lin, JH; Lin, Y; Rodrigues, AD; Tang, C | 1 |
| Komatsu, T; Nakajima, M; Yamazaki, H; Yokoi, T | 1 |
| Kume, T; Nakajima, M; Ohashi, N; Sakata, N; Yokoi, T | 1 |
| Hashimoto, Y; Hasunuma, M; Okabe, H | 1 |
| Rainey, PM; Roberts, WL | 1 |
| Chan, YW; Chu, TS; Fok, TF; Fung, KP; Fung, LW; Ho, YY; Wong, HY | 1 |
| Ding, H; Yao, T; Zeng, S | 1 |
| Hara, Y; Katoh, M; Nakajima, M; Tachibana, O; Yamanaka, H; Yamashita, J; Yokoi, T | 1 |
| Allabi, AC; Gala, JL; Horsmans, Y | 1 |
| Argikar, UA; Birnbaum, AK; Cloyd, JC; Conway, J; Klein, EC; Kshirsagar, S; Leppik, IE; Oetting, WS; Remmel, RP | 1 |
| Gorman, LA; Kumar, V; Rock, DA; Tracy, TS; Wahlstrom, JL; Warren, CJ | 1 |
| Kang, HE; Kim, YC; Lee, MG | 1 |
| Fuhr, U; Jaehde, U; Jetter, A; Kasel, D; Kirchheiner, J; Klaassen, T; Tomalik-Scharte, D | 1 |
| Mosher, CM; Rettie, AE; Tai, G | 1 |
| Li, XY; Li, YP; Liu, YN; Yang, YZ; Yuan, M; Zhu, JB | 1 |
| DeOrazio, RJ; Fitzpatrick, K; Guo, C; Guzzo, PR; Hu, M; Khmelnitsky, Y; Kitchen, DB; Liu, S; Luche, M; Maeng, JH; Mhyre, AJ; Tom, S; Usyatinsky, A; Zhang, Z | 1 |
| Bridgewater, B; Feng, S; McIntire, G; Strickland, EC | 1 |
| Jiang, L; Li, W; Liu, Y; Lv, X; Wang, X; Wang, Z; Yin, H | 1 |
1 review(s) available for hydroxyphenytoin and phenytoin
| Article | Year |
|---|---|
Phenytoin: pharmacogenetic polymorphism of 4'-hydroxylation.
Topics: Animals; Humans; Phenytoin; Polymorphism, Genetic | 1990 |
3 trial(s) available for hydroxyphenytoin and phenytoin
| Article | Year |
|---|---|
Limited value of the urinary phenytoin metabolic ratio for the assessment of cytochrome P4502C9 activity in vivo.
Topics: Adult; Anticonvulsants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Female; Humans; Hypoglycemic Agents; Male; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide | 1996 |
Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese.
Topics: Administration, Oral; Alleles; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Genotype; Homozygote; Humans; Hydroxylation; Japan; Mixed Function Oxygenases; Omeprazole; Phenotype; Phenytoin; Polymerase Chain Reaction; Polymorphism, Genetic; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1997 |
Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus.
Topics: Alleles; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Epilepsy; Exons; Humans; Japan; Mutation; Phenytoin; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 2000 |
79 other study(ies) available for hydroxyphenytoin and phenytoin
| Article | Year |
|---|---|
Determination of 5-(p-hydroxyphenyl)-5-phenylhydantoin and studies relating to the disposition of phenytoin in man.
Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Phenytoin | 1979 |
High-pressure liquid-chromatographic determination of 5-(4-hydroxyphenyl)-5-phenylhydantoin in humanurine.
Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Phenytoin | 1976 |
Mass fragmentographic determination of diphenylhydantoin and its main metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, in human plasma.
Topics: Alkylation; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Methods; Microchemistry; Phenytoin; Temperature | 1976 |
[High performance liquid chromatographic determination of hydroxyphenytoin in human urine].
Topics: Chromatography, High Pressure Liquid; Humans; Phenytoin | 1992 |
Phenytoin metabolism during pregnancy.
Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Time Factors | 1992 |
Stereoselective inhibition of diphenylhydantoin metabolism by p-hydroxyphenyl-phenylhydantoin enantiomers in rats.
Topics: Animals; In Vitro Techniques; Male; Microsomes, Liver; Phenytoin; Rats; Rats, Inbred Strains; Stereoisomerism | 1991 |
S-mephenytoin 4-hydroxylation in older Americans.
Topics: Aged; Aging; Aryl Hydrocarbon Hydroxylases; Black People; Chromatography, High Pressure Liquid; Creatinine; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Mephenytoin; Mixed Function Oxygenases; Phenytoin; United States; White People | 1991 |
Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin.
Topics: Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Hydroxylation; Male; Oxidation-Reduction; Phenytoin; Rats | 1990 |
Drug interaction between phenytoin and allopurinol.
Topics: Administration, Oral; Allopurinol; Animals; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Kidney; Liver; Male; Phenytoin; Rats; Rats, Inbred Strains; Regional Blood Flow | 1990 |
Direct high-performance liquid chromatographic analysis of p-hydroxyphenyl-phenylhydantoin glucuronide, the final metabolite of phenytoin, in human serum and urine.
Topics: Chromatography, High Pressure Liquid; Epilepsy; Glucuronates; Glucuronidase; Humans; Phenytoin; Stereoisomerism | 1990 |
The effect of varying extents of Fluosol-DA or normal saline haemodilution on the dose dependent kinetics of phenytoin in the rat.
Topics: Animals; Blood Substitutes; Dose-Response Relationship, Drug; Drug Combinations; Fluorocarbons; Half-Life; Hemodilution; Hydroxyethyl Starch Derivatives; Phenytoin; Rats | 1989 |
Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta.
Topics: Animals; Antipyrine; Female; Humans; In Vitro Techniques; Male; Maternal-Fetal Exchange; Metabolic Clearance Rate; Perfusion; Phenytoin; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Solubility | 1989 |
Teratogenicity of phenylhydantoins in an in vitro system: molecular orbital-generated quantitative structure-toxicity relationships.
Topics: Animals; Cells, Cultured; Female; Hydantoins; Molecular Conformation; Phenytoin; Pregnancy; Rats; Structure-Activity Relationship; Teratogens | 1989 |
Correlations between embryotoxic and genotoxic effects of phenytoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cell Nucleus; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Epoxide Hydrolases; Female; Fetal Death; Fetal Diseases; Fetal Resorption; Male; Mice; Mutagenicity Tests; Phenytoin; Pregnancy | 1987 |
Phenytoin pharmacokinetics in critically ill trauma patients.
Topics: Adult; Aged; Analysis of Variance; Computer Simulation; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Phenytoin; Protein Binding; Serum Albumin; Wounds and Injuries | 1988 |
False-positive barbiturate test in urine owing to phenytoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin.
Topics: Barbiturates; False Positive Reactions; Humans; Immunoassay; Phenytoin; Quality Control | 1988 |
Phenytoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin do not alter the effects of bacterial and amplified plaque extracts on cultures of fibroblasts from normal and overgrown gingivae.
Topics: Actinomyces; Adult; Bacterial Physiological Phenomena; Cell Count; Cell Division; Cells, Cultured; Dental Plaque; Fibroblasts; Gingiva; Gingival Hyperplasia; Humans; Phenytoin; Streptococcus; Veillonella | 1987 |
Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Brain; Cleft Palate; Drug Synergism; Embryo Loss; Female; Housing, Animal; Liver; Metabolic Clearance Rate; Mice; Phenytoin; Placenta; Pregnancy; Teratogens | 1986 |
Evidence for stereoselective production of phenytoin (5,5-diphenylhydantoin) arene oxides in man.
Topics: Adolescent; Adult; Biotransformation; Child; Chromatography, High Pressure Liquid; Female; Humans; Male; Phenytoin; Stereoisomerism | 1986 |
Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro.
Topics: Adult; Benzimidazoles; Coumarins; Diazepam; Drug Interactions; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nordazepam; Omeprazole; Oxidation-Reduction; Phenytoin | 1985 |
Gas chromatographic determination of m- and p-hydroxyphenytoin in the urine of epileptic patients.
Topics: Adult; Aged; Carbamazepine; Chromatography, Gas; Epilepsy; Female; Humans; Hydrolysis; Male; Phenytoin; Urea | 1985 |
Extent of urinary excretion of p-hydroxyphenytoin in healthy subjects given phenytoin.
Topics: Adult; Biological Availability; Female; Glucuronates; Humans; Kinetics; Male; Phenytoin | 1985 |
Michaelis-Menten kinetics and the steady-state serum phenytoin/hydroxyphenytoin ratio.
Topics: Adolescent; Adult; Child; Epilepsy; Half-Life; Humans; Kinetics; Middle Aged; Phenytoin | 1985 |
Metabolic interactions of phenytoin in the rat: effect of coadministration with the anticonvulsant drugs sodium valproate, sulthiame, ethosuximide or phenobarbital.
Topics: Animals; Anticonvulsants; Brain; Drug Interactions; Ethosuximide; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Thiazines; Valproic Acid | 1984 |
Contribution of 5-(4-hydroxyphenyl)-5-phenylhydantoin to the discrepancy between phenytoin analyses by EMIT and high-pressure liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Phenytoin; Plasma; Uremia | 1984 |
[Examination of phenytoin metabolites in rat urine].
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Indicator Dilution Techniques; Male; Phenytoin; Rats | 1983 |
Phenytoin metabolism in the cat after long-term oral administration.
Topics: Administration, Oral; Animals; Cats; Feces; Female; Male; Phenytoin | 1984 |
Analysis of p-hydroxyphenytoin in microsomal reactions by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Electrochemistry; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenytoin; Rats; Rats, Inbred Strains | 1984 |
Routine determination of hydroxyphenytoin in urine by high-performance liquid chromatography using an automatic column-switching technique.
Topics: Chromatography, High Pressure Liquid; Epilepsy; Humans; Phenytoin; Statistics as Topic | 1983 |
Flow cytometric analysis of the effect of phenytoin and its major metabolite on mitogen stimulated mouse spleen cells.
Topics: Animals; Cell Cycle; Cells, Cultured; Concanavalin A; Demecolcine; Flow Cytometry; Lipopolysaccharides; Lymphocyte Activation; Mice; Phenytoin; Spleen | 1983 |
Tissue assay of phenobarbital, phenytoin and p-hydroxyphenytoin by high-performance liquid chromatography.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Female; Fetus; Hydrogen-Ion Concentration; Kinetics; Liver; Phenobarbital; Phenytoin; Pregnancy; Rats; Spectrophotometry, Ultraviolet | 1984 |
Urinary hydroxyphenytoin/creatinine ratios as an index of compliance in adult epileptic patients on phenytoin therapy.
Topics: Creatinine; Epilepsy; Female; Humans; Male; Models, Biological; Patient Compliance; Phenytoin | 1984 |
Interaction between phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin and valproate in the rat.
Topics: Animals; Blood Proteins; Drug Interactions; Kinetics; Metabolic Clearance Rate; Phenytoin; Protein Binding; Rats; Valproic Acid | 1981 |
High-performance liquid chromatographic determination of phenytoin and hydroxyphenytoin in human urine.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin | 1983 |
Impairment of phenytoin parahydroxylation as a cause of severe intoxication.
Topics: Aged; Antipyrine; Debrisoquin; Humans; Hydroxylation; Kinetics; Male; Phenytoin | 1983 |
Quantitative histopathologic assessment of developing phenytoin-induced gingival overgrowth in the cat.
Topics: Animals; Cats; Connective Tissue; Disease Models, Animal; Female; Fibroblasts; Gingiva; Gingival Hyperplasia; Male; Phenytoin; Time Factors | 1982 |
A gas chromatographic/mass spectrometric method for the simultaneous quantitation of 5,5-diphenylhydantoin (phenytoin), its para-hydroxylated metabolite and their stable isotope labelled analogs.
Topics: Carbon Radioisotopes; Gas Chromatography-Mass Spectrometry; Humans; Nitrogen Radioisotopes; Phenytoin; Radioisotope Dilution Technique | 1981 |
Mutagenicity of diphenylhydantoin and some of its metabolites towards salmonella typhimurium strains.
Topics: Animals; Biotransformation; Liver; Male; Microsomes, Liver; Mutagenicity Tests; Phenytoin; Polycyclic Compounds; Rats; Salmonella typhimurium | 1982 |
Hemodialysis reduces the unbound phenytoin in plasma.
Topics: Adolescent; Adult; Blood Proteins; Body Weight; Child; Humans; Phenytoin; Protein Binding; Renal Dialysis; Serum Albumin | 1982 |
The effect of diethylstilbestrol treatment on the metabolism and biliary excretion of [14C]phenytoin in the isolated perfused rat liver.
Topics: Animals; Bile; Diethylstilbestrol; Female; In Vitro Techniques; Liver; Perfusion; Phenytoin; Rats | 1981 |
[Quantitative measurement of phenytoin and hydroxyphenytoin in human serum by column extraction-high-performance liquid chromatography (author's transl)].
Topics: Adolescent; Adult; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Phenytoin | 1980 |
Effect of heparin or salicylate infusion on serum protein binding and on concentrations of phenytoin in serum, brain and cerebrospinal fluid of rats.
Topics: Animals; Blood Proteins; Brain; Drug Interactions; Female; Heparin; Phenytoin; Protein Binding; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1981 |
Effect of diphenylhydantoin and its main hydroxylated metabolite on the pharmacokinetics and the urinary and biliary excretion of phenobarbital and its p-hydroxy metabolite.
Topics: Animals; Bile; Half-Life; Kinetics; Male; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Tissue Distribution | 1981 |
Liquid-chromatographic method for simultaneous determination of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in plasma and urine.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Humans; Microchemistry; Phenobarbital; Phenytoin; Urine | 1980 |
Phenytoin metabolism in pregnancy.
Topics: Adult; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy Complications; Prospective Studies; Time Factors | 1980 |
Pharmacokinetics of phenytoin in children with acute neurotrauma.
Topics: Acute Disease; Adolescent; Age Factors; Child; Child, Preschool; Craniocerebral Trauma; Drug Monitoring; Female; Humans; Infant; Infusions, Intravenous; Male; Phenytoin; Prospective Studies | 1995 |
Metabolism of phenytoin and covalent binding of reactive intermediates in activated human neutrophils.
Topics: Antioxidants; Biotransformation; Chelating Agents; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Phenytoin; Proteins; Tetradecanoylphorbol Acetate | 1995 |
Analysis of mephenytoin, 4-hydroxymephenytoin and 4-hydroxyphenytoin enantiomers in human urine by cyclodextrin micellar electrokinetic capillary chromatography: simple determination of a hydroxylation polymorphism in man.
Topics: Buffers; Capillary Action; Chromatography; Cyclodextrins; Humans; Hydroxylation; Kinetics; Mephenytoin; Micelles; Phenytoin; Stereoisomerism | 1994 |
The phenytoin metabolite p-HPPH upregulates prostaglandin biosynthesis in human gingival fibroblasts challenged to interleukin-1.
Topics: Cells, Cultured; Child; Drug Synergism; Female; Fibroblasts; Gingiva; Humans; Interleukin-1; Male; Phenytoin; Prostaglandins; Tumor Necrosis Factor-alpha; Up-Regulation | 1993 |
Effect of phenytoin on interleukin-1 beta production in human gingival fibroblasts challenged to tumor necrosis factor alpha in vitro.
Topics: Child; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Fibroblasts; Flurbiprofen; Gingiva; Gingival Hyperplasia; Humans; Indomethacin; Interleukin-1; Phenytoin; Tumor Necrosis Factor-alpha; Up-Regulation | 1996 |
Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study.
Topics: Adult; Aged; Anticonvulsants; Chronic Disease; Female; Gingival Hyperplasia; Humans; In Vitro Techniques; Male; Middle Aged; Phenytoin; Stereoisomerism | 1995 |
Plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in relation to the incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients.
Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Middle Aged; Phenytoin; Saliva; Statistics, Nonparametric | 1996 |
Simultaneous determination of plasma phenytoin and its primary hydroxylated metabolites in carbon tetrachloride-intoxicated rats by high-performance liquid chromatography.
Topics: Animals; Anticonvulsants; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry | 1995 |
Oxaprozin and 5-(p-hydroxyphenyl)-5-phenylhydantoin interference in phenytoin immunoassays.
Topics: Antibodies, Monoclonal; Cross Reactions; Humans; Immunoassay; Oxaprozin; Phenytoin; Propionates; Reagent Kits, Diagnostic; Renal Insufficiency; Sensitivity and Specificity | 1997 |
Phenytoin hydroxylation in a healthy Caucasian population: bimodal distribution of hydroxyphenytoin urinary excretion.
Topics: Administration, Oral; Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Cohort Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxylation; Life Style; Male; Phenytoin; Polymorphism, Genetic; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; White People | 1997 |
Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19.
Topics: Antibodies; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Japan; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Saccharomyces cerevisiae; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity | 1999 |
The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Gingival Overgrowth; Humans; Male; Middle Aged; Phenytoin; Saliva; Time Factors | 1999 |
Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria.
Topics: Animals; Bone Resorption; Mice; Organ Culture Techniques; Phenytoin; Skull | 2000 |
Stereoselective determination of p-hydroxyphenyl-phenylhydantoin enantiomers in rat liver microsomal incubates by reversed-phase high-performance liquid chromatography using beta-cyclodextrin as chiral mobile phase additives.
Topics: Animals; beta-Cyclodextrins; Chromatography, High Pressure Liquid; Cyclodextrins; Male; Microsomes, Liver; Phenytoin; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2001 |
Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo.
Topics: Adult; Biomarkers; Cytochrome P-450 Enzyme System; Genotype; Humans; Isoenzymes; Male; Metabolic Clearance Rate; Phenytoin | 2001 |
Modeling and kinetic analysis of the reaction system using whole cells with separately and co-expressed D-hydantoinase and N-carbamoylase.
Topics: Agrobacterium tumefaciens; Amidohydrolases; Catalysis; Computer Simulation; Geobacillus stearothermophilus; Glycine; Hydrogen-Ion Concentration; Models, Biological; Models, Chemical; Phenytoin; Sensitivity and Specificity; Stereoisomerism | 2002 |
Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding.
Topics: Humans; In Vitro Techniques; Microsomes, Liver; Phenytoin; Protein Binding; Serum Albumin, Bovine; Tolbutamide | 2002 |
Identification of catalase in human livers as a factor that enhances phenytoin dihydroxy metabolite formation by human liver microsomes.
Topics: Catalase; Cytochrome P-450 Enzyme System; Cytosol; Humans; Hydroxylation; Liver; Microsomes, Liver; Phenytoin; Recombinant Proteins | 2002 |
Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin in human liver microsomes.
Topics: Biotransformation; Glucuronides; Glucuronosyltransferase; Humans; Isoenzymes; Kinetics; Mass Spectrometry; Microsomes, Liver; Phenytoin; Substrate Specificity | 2002 |
The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.
Topics: Animals; Cisplatin; Cytochrome P-450 Enzyme System; Debrisoquin; Glycerol; Hydroxylation; Hydroxytestosterones; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Microsomes, Liver; Nephrectomy; Phenytoin; Rats; Rats, Wistar; Renal Insufficiency | 2003 |
Phenytoin overview--metabolite interference in some immunoassays could be clinically important.
Topics: Cross Reactions; Humans; Immunoassay; Kidney Failure, Chronic; Phenytoin | 2004 |
The effects of phenytoin and its metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin on cellular glucose transport.
Topics: 3-O-Methylglucose; Animals; Astrocytes; Biological Transport; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes; Fibroblasts; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Glucose Transporter Type 5; Humans; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Phenytoin; Polymerase Chain Reaction; Rats; Time Factors | 2005 |
[Chiral separation of racemic 5-(p-hydroxyphenyl)-5-phenylhydantoin by RP-HPLC using eluents containing beta-cyclodextrin].
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cyclodextrins; Microsomes, Liver; Phenytoin; Rats; Stereoisomerism | 1997 |
Urinary excretion of phenytoin metabolites, 5-(4'-hydroxyphenyl)-5-phenylhydantoin and its O-glucuronide in humans and analysis of genetic polymorphisms of UDP-glucuronosyltransferases.
Topics: Adolescent; Adult; Anticonvulsants; Female; Glucuronosyltransferase; Humans; Male; Middle Aged; Phenytoin; Polymorphism, Genetic | 2005 |
CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population.
Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benin; Black People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Female; Genetic Variation; Genetics, Population; Genotype; Haplotypes; Humans; Male; Middle Aged; Mixed Function Oxygenases; Pharmacogenetics; Phenytoin; Polymorphism, Genetic | 2005 |
Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Mixed Function Oxygenases; Mutation; Phenytoin; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Stereoisomerism | 2006 |
CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diclofenac; Enzyme Inhibitors; Flurbiprofen; Genotype; In Vitro Techniques; Pharmacogenetics; Phenytoin; Piroxicam; Tolbutamide; Warfarin | 2006 |
Pharmacokinetics of phenytoin and its metabolite, 4'-HPPH, after intravenous and oral administration of phenytoin to diabetic rats induced by alloxan or streptozotocin.
Topics: Administration, Oral; Alloxan; Animals; Anticonvulsants; Area Under Curve; Blood Proteins; Diabetes Mellitus, Experimental; Half-Life; Hydantoins; Injections, Intravenous; Liver; Phenytoin; Protein Binding; Rats; Rats, Sprague-Dawley; Streptozocin | 2008 |
Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Data Interpretation, Statistical; Humans; Male; Mass Spectrometry; Mephenytoin; Middle Aged; Oxidoreductases, N-Demethylating; Phenotype; Phenytoin | 2008 |
CYP2C9 amino acid residues influencing phenytoin turnover and metabolite regio- and stereochemistry.
Topics: Amino Acid Substitution; Amino Acids; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Catalytic Domain; Cytochrome P-450 CYP2C9; Humans; Kinetics; Models, Molecular; Phenytoin; Recombinant Fusion Proteins; Stereoisomerism; Tandem Mass Spectrometry; Warfarin | 2009 |
[Effect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Altitude; Animals; Cytochrome P-450 Enzyme System; Enzyme Activation; Female; Hypoxia; Male; Omeprazole; Phenytoin; Rats; Rats, Sprague-Dawley | 2012 |
The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.
Topics: Dose-Response Relationship, Drug; Drug Design; Glycosides; Humans; Molecular Structure; Phenytoin; Pyridones; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Structure-Activity Relationship; Triazoles | 2014 |
A Rapid LC-MS-MS Method for the Quantitation of Antiepileptic Drugs in Urine.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Liquid; Drug Monitoring; Humans; Lamotrigine; Levetiracetam; Oxcarbazepine; Phenytoin; Tandem Mass Spectrometry; Topiramate | 2020 |
Potential herb-drug interaction risk of thymoquinone and phenytoin.
Topics: Benzoquinones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Herb-Drug Interactions; Hydroxylation; Kinetics; Nigella; Phenytoin; Tandem Mass Spectrometry | 2022 |