hydroxymethyltolbutamide has been researched along with tolbutamide in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (26.09) | 18.7374 |
| 1990's | 13 (56.52) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boutagy, JS; Page, MA; Shenfield, GM | 1 |
| Birkett, DJ; Gregov, D; Miners, JO; Randles, D; Veronese, ME | 1 |
| Adir, J; Miller, AK; Vestal, RE | 1 |
| Belanger, PM; St-Hilaire, S | 1 |
| Back, DJ; Breckenridge, AM; Bunnag, D; Karbwang, J | 1 |
| Keal, J; Somogyi, A; Stockley, C | 1 |
| Back, DJ; Tjia, JF | 1 |
| Back, DJ; Sutcliffe, F; Tjia, JF | 1 |
| Albasini, A; Manenti, F; Melegari, M; Pecorari, P; Vampa, G | 1 |
| Gonzalez, FJ; Korzekwa, KR; Rettie, AE; Trager, WF; Wienkers, LC | 1 |
| Ho, JW; Moody, DE | 1 |
| Makaya, O; Nakamura, J; Nishida, K; Sasaki, H; Shibasaki, J; Washio, K | 1 |
| Birkett, DJ; Miners, JO; Rees, DL; Veronese, ME | 1 |
| Gross, AS; Rieutord, A; Shenfield, GM; Stupans, I | 1 |
| Birkett, DJ; Miners, JO | 1 |
| Ho, JW; Leung, YK | 1 |
| Bridge, S; Gross, AS; Shenfield, GM | 1 |
| Belpaire, FM; De Vriendt, C; Hemeryck, A | 1 |
| Brøsen, K; Hansen, LL | 1 |
| Bauer, S; Brockmöller, J; Kirchheiner, J; Meineke, I; Meisel, C; Prang, V; Rohde, W; Roots, I | 1 |
| Cha, IJ; Flockhart, DA; Kim, KA; Lee, KJ; Lim, YC; Park, JY; Shin, JG; Shon, JH; Yoon, YR | 1 |
| Lin, JH; Lin, Y; Rodrigues, AD; Tang, C | 1 |
| Brockmöller, J; Fuhr, U; Hering, U; Jabrane, W; Jakob, V; Jetter, A; Kasel, D; Kinzig-Schippers, M; Kirchheiner, J; Lazar, A; Rodamer, M; Skott, A; Sörgel, F; Tomalik-Scharte, D; Walchner-Bonjean, M | 1 |
2 trial(s) available for hydroxymethyltolbutamide and tolbutamide
| Article | Year |
|---|---|
Pharmacokinetics of tolbutamide in ethnic Chinese.
Topics: Adult; Asian People; Chromatography, High Pressure Liquid; Female; Humans; Male; Tolbutamide; White People | 1999 |
Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Evaluation; Female; Genotype; Heterozygote; Homozygote; Humans; Hydroxylation; Hypoglycemic Agents; Male; Mixed Function Oxygenases; Polymorphism, Genetic; Single-Blind Method; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tolbutamide | 2002 |
21 other study(ies) available for hydroxymethyltolbutamide and tolbutamide
| Article | Year |
|---|---|
A screening test for slow metabolisers of tolbutamide.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Male; Middle Aged; Pilot Projects; Polymorphism, Genetic; Reference Values; Tolbutamide | 1991 |
Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers.
Topics: Administration, Oral; Adult; Chromatography; Female; Half-Life; Humans; Hydroxylation; Male; Phenotype; Random Allocation; Sulfaphenazole; Tolbutamide | 1990 |
Excretion of tolbutamide metabolites in young and old subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Humans; Male; Middle Aged; Tolbutamide | 1990 |
Simultaneous determinations of tolbutamide and its hydroxy and carboxy metabolites in serum and urine: application to pharmacokinetic studies of tolbutamide in the rat.
Topics: Animals; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Rats; Rats, Inbred Strains; Tolbutamide | 1989 |
Inhibition of tolbutamide metabolism by antimalarial drugs.
Topics: Adult; Aged; Antimalarials; Child, Preschool; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Tolbutamide | 1988 |
Simultaneous determination of tolbutamide and its hydroxy and carboxy metabolites in plasma and urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Tolbutamide | 1986 |
Inhibition of tolbutamide metabolism by substituted imidazole drugs in vivo: evidence for a structure-activity relationship.
Topics: Animals; Depression, Chemical; Half-Life; Imidazoles; Kinetics; Liver; Male; Metabolic Clearance Rate; Rats; Structure-Activity Relationship; Tolbutamide | 1985 |
Tolbutamide as a model drug for the study of enzyme induction and enzyme inhibition in the rat.
Topics: Animals; Chloroquine; Cimetidine; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Kinetics; Male; Phenobarbital; Primaquine; Rats; Rats, Inbred Strains; Substrate Specificity; Tolbutamide | 1984 |
An HPLC method for the simultaneous determination of tolbutamide and its metabolites in plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Tolbutamide | 1981 |
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Humans; Recombinant Proteins; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Tolbutamide; Tumor Cells, Cultured; Warfarin | 1994 |
Determination of tolbutamide hydroxylation in rat liver microsomes by high-performance liquid chromatography: effect of psychoactive drugs on in vitro activity.
Topics: Animals; Chromatography, High Pressure Liquid; Hydroxylation; In Vitro Techniques; Male; Microsomes, Liver; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Tolbutamide | 1993 |
A new aspect of tolbutamide metabolism in the rabbit: the role of 1-butyl-3-(p-formylphenyl)sulphonylurea.
Topics: Animals; Chromatography, High Pressure Liquid; Disulfiram; Male; Oxidation-Reduction; Rabbits; Tolbutamide | 1993 |
Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjects.
Topics: Adolescent; Adult; Female; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Middle Aged; Tolbutamide | 1993 |
Gliclazide hydroxylation by rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Gliclazide; Glipizide; Glyburide; Hydroxylation; Hypoglycemic Agents; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; Tolbutamide | 1995 |
Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9.
Topics: Aryl Hydrocarbon Hydroxylases; Chlorpropamide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Humans; Hypoglycemic Agents; In Vitro Techniques; Microsomes, Liver; Molecular Probes; Reproducibility of Results; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Tolbutamide | 1996 |
Inhibitory effect of nicotine and its metabolites on tolbutamide hydroxylation in rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Cotinine; Fluorescence; Hydroxylation; Hypoglycemic Agents; Microsomes, Liver; Molecular Structure; Nicotine; Rats; Sensitivity and Specificity; Smoking; Tolbutamide | 1998 |
Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Fluvoxamine; Humans; In Vitro Techniques; Microsomes, Liver; Middle Aged; Selective Serotonin Reuptake Inhibitors; Statistics as Topic; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Time Factors; Tolbutamide; Warfarin | 1999 |
Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection.
Topics: Chromatography, High Pressure Liquid; Humans; Hypoglycemic Agents; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tolbutamide | 1999 |
Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers.
Topics: Adult; Alleles; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Evaluation; Female; Genotype; Humans; Hypoglycemic Agents; Insulin; Male; Mixed Function Oxygenases; Polymorphism, Genetic; Population Surveillance; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Time Factors; Tolbutamide | 2002 |
Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding.
Topics: Humans; In Vitro Techniques; Microsomes, Liver; Phenytoin; Protein Binding; Serum Albumin, Bovine; Tolbutamide | 2002 |
Cytochrome P450 2C9 phenotyping using low-dose tolbutamide.
Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Exons; Genotype; Humans; Male; Mass Spectrometry; Metabolic Clearance Rate; Middle Aged; Pharmacogenetics; Phenotype; Pilot Projects; Sequence Analysis, DNA; Time Factors; Tolbutamide | 2004 |