hydroxymaprotilin has been researched along with maprotiline in 100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (51.00) | 18.7374 |
| 1990's | 43 (43.00) | 18.2507 |
| 2000's | 5 (5.00) | 29.6817 |
| 2010's | 1 (1.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Arendt, J; Checkley, SA; Everitt, B; Palazidou, E; Skene, D | 1 |
| Inukai, T; Noguchi, S | 1 |
| Inukai, T; Kuno, T; Noguchi, S; Tanaka, C | 1 |
| Bieck, PR; Duhl, DM; Gillespie, DD; Manier, DH; Sulser, F | 1 |
| Maj, J; Rogóz, Z; Skuza, G; Sowińska, H | 2 |
| Inukai, T; Noguchi, S; Okada, M | 1 |
| Birnstiel, S; Haas, HL | 1 |
| Bornová, L; David, I; Filip, V; Höschl, C; Karen, P; Seifertová, D | 1 |
| Fukuda, Y; Inukai, T; Noguchi, S | 1 |
| Ackermann, R; Bieck, PR; Dieterle, W; Kaiser, G; Reimann, IW | 1 |
| Schultheiss, A; Starke, K; Szabo, B | 1 |
| Budziszewska, B; Grochmal, A; Przegaliński, E | 1 |
| Hole, G; Keller, F; Steiner, B; Straub, R; Wolfersdorf, M | 1 |
| Bönisch, H; Coppeneur, D; Lingen, B; Martiny-Baron, G; Paulus, G | 1 |
| Tejani-Butt, SM | 1 |
| Klimek, V; Maj, J; Rogóz, Z; Skuza, G; Sowińska, H | 1 |
| Ackermann, R; Dieterle, W; Kaiser, G; Schueller, F | 1 |
| Delini-Stula, A; Herrmann, WM; Schärer, E; Wendt, G | 1 |
| Bianchi, E; Brunello, N; Perez, J; Racagni, G; Tinelli, D | 1 |
| Müller, WE; Schubert, T | 1 |
| Carboni, E; Di Chiara, G; Frau, R; Tanda, GL | 1 |
| Klimek, V; Maj, J; Rogóz, Z; Skuz, G; Wedzony, K | 1 |
| Jones, RS; Mondadori, C; Olpe, HR | 1 |
| Bieck, PR; Hoffmann, E; Jedrychowski, M | 1 |
| Bigajska, K; Maj, J; Papp, M; Skuza, G; Zazula, M | 1 |
| Bijak, M | 1 |
| Faltus, F; Janecková, E; Koníková, M; Krekule, P; Molcan, J; Mrna, B; Náhunek, K; Pazdírek, S; Svestka, J; Zapletálek, M | 1 |
| Cesková, E; Misurec, J; Náhunek, K; Obrovská, V; Rysánek, R; Svestka, J; Wendt, G | 1 |
| Faltus, F; Janecková, E | 1 |
| Cesková, E; Mayer, P; Náhunek, K; Rysánek, R; Svestka, J | 1 |
| Katz, RJ | 1 |
| Starke, K; Wichmann, T | 1 |
| Mogilnicka, E; Wedzony, K; Zazula, M | 1 |
| Kraemer, GW; McKinney, WT | 1 |
| Feuerstein, TJ; Hertting, G; Jackisch, R | 1 |
| Binz, U; Hole, G; Steiner, B; Wendt, G; Wolfersdorf, M | 1 |
| Berger, M; Emrich, HM; Riemann, D; von Zerssen, D | 1 |
| Blansjaar, BA; Dijken, WA; Haffmans, J; Kamp, JS; Kramer, HJ; Nolen, WA; van de Putte, JJ | 2 |
| Bakish, D; Browne, M; Horn, E; Hrdina, PD; Lapierre, YD | 1 |
| Li, A; Marek, GJ; Seiden, LS | 1 |
| Chouchane, L; Hoebeke, J; Strosberg, AD | 1 |
| Abrahamsson, T; Carlsson, L | 1 |
| Binz, U; Hole, G; Metzger, R; Wendt, G; Wolfersdorf, M | 1 |
| Delini-Stula, A; Mogilnicka, E | 1 |
| Maj, J; Wedzony, K | 1 |
| Horne, C; Mutschler, E; Spahn, H | 1 |
| Axmann, D; Breyer-Pfaff, U; Gaertner, H; Giedke, H; Rein, W | 1 |
| Lautin, A; Novatt, A; Peselow, ED; Rohrs, C; Rotrosen, J; Siekierski, J; Wolkin, A | 1 |
| Gnirss, FA | 1 |
| Giedke, H; Heimann, H | 1 |
| Giedke, H; Heimann, H; Rein, W | 1 |
| Feuerstein, TJ; Hertting, G | 1 |
| Dieterle, W; Faigle, JW; Kriemler, HP; Winkler, T | 2 |
| Blaschke, D; Dieterle, D; Laakmann, G; Schmauss, M | 1 |
| Arendt, J; Burton, S; Checkley, SA; Franey, C; Thompson, C | 1 |
| Dijken, WA; Kamp, JS; Nolen, WA; van de Putte, JJ | 1 |
| Breyer-Pfaff, U; Kriemler, P; Kroeker, M; Winkler, T | 1 |
| Boissard, CG; Delini-Stula, A; Hunn, C; Mogilnicka, E | 1 |
| Maj, J; Rogóz, Z; Skuza, G | 1 |
| Boissard, CG; Delini-Stula, A; Mogilnicka, E; Waldmeier, PC | 1 |
| Golden, RN; Potter, WZ; Rudorfer, MV | 1 |
| Baumann, P; Delini-Stula, A; Hauser, K; Olpe, HR; Storni, A; Waldmeier, P | 1 |
| Gillespie, DD; Lovell, RA; Mishra, R; Robson, RD; Sulser, F | 1 |
| Dieterle, W; Faigle, JW; Imhof, P; Sulc, M; Wagner, J | 1 |
| Breyer-Pfaff, U; Nill, K; Wiatr, R | 1 |
| Breyer-Pfaff, U; Gaertner, HJ; Giedke, H | 1 |
| Dieterle, W; Faigle, JW | 1 |
| Binz, U; Wendt, G | 1 |
| Baumann, PA; Hauser, K; Maitre, L; Storni, A; Waldmeier, PC | 1 |
| Gundert-Remy, U; Mäurer, W; Schmidlin, O; Weber, E | 1 |
| Feistenauer, E; Kuss, HJ | 1 |
| Obergfell, A; Starke, K; Szabo, B | 1 |
| Beauchamp, G; Elie, R; Lavoie, PA | 1 |
| Klimek, V; Mackowiak, M; Zak-Knapik, J | 1 |
| Bornová, L; Filip, V; Höschl, C; Karen, P; Prasko, J; Prasková, H; Seifertová, D | 1 |
| Auberle, T; Starke, K; Szabo, B | 1 |
| Andrade, C | 1 |
| Albrecht, V; David, I; Filip, V; Höschl, C; Palus, M; Prasková, H; Seifertová, D | 1 |
| Benkert, O; Gerken, A; Holsboer, F; Steiger, A | 1 |
| Angst, J; Delini-Stula, A; Stassen, HH | 1 |
| Antonin, KH; Bieck, PR; Firkusny, L; Reimann, IW | 1 |
| Feuerstein, TJ; Göthert, M; Lupp, A; Mutschler, A; Schlicker, E; Van Velthoven, V | 1 |
| Götz, E; Meyer, DK; Mondeh, JD; Olenik, C; Uhl, A | 1 |
| Katz, RJ; Landau, P; Lott, M; Waldmeier, P | 1 |
| Parker, G | 1 |
| Nörenberg, W; Schöffel, E; Starke, K; Szabo, B | 1 |
| Dziedzicka-Wasylewska, M; Klimek, V; Maj, J; Rogoz, R | 1 |
| Eiring, A; Sulser, F | 1 |
| Gray, AM; Sewell, RD; Spencer, PS | 1 |
| Gray, AM; Pache, DM; Sewell, RD | 1 |
| Eckhardt, K; Feuerstein, TJ; Günter, T; Roth, P; Schmidt, S | 1 |
| Ding, YS; Lin, KS | 1 |
| Benveniste, H; Carter, P; Ding, YS; Lin, KS; Logan, J | 1 |
| Bubl, B; Feuerstein, TJ; Hubbe, U; Huethe, F; Jackisch, R; Löffler, M; McIntosh, JM | 1 |
| Birthelmer, A; Ehret, A; Jackisch, R; Leemhuis, J; Riegert, C; Rothmaier, AK | 1 |
| Faltus, F; Janecková, E; Papezová, H | 1 |
2 review(s) available for hydroxymaprotilin and maprotiline
| Article | Year |
|---|---|
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trials as Topic; Dopamine; Double-Blind Method; Humans; Maprotiline; Nomifensine; Norepinephrine; Propiophenones; Propylamines; Seizures; Serotonin; Trazodone; Zimeldine | 1984 |
Time course of improvement under antidepressant treatment: a survival-analytical approach.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analysis of Variance; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Maprotiline; Middle Aged; Models, Statistical; Psychiatric Status Rating Scales; Single-Blind Method; Time Factors | 1993 |
28 trial(s) available for hydroxymaprotilin and maprotiline
| Article | Year |
|---|---|
The acute and chronic effects of (+) and (-) oxaprotiline upon melatonin secretion in normal subjects.
Topics: Administration, Oral; Adult; Antidepressive Agents; Double-Blind Method; Humans; Male; Maprotiline; Melatonin; Norepinephrine; Pineal Gland; Receptors, Adrenergic; Stereoisomerism | 1992 |
[Results of a clinical trial of levoprotiline].
Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Maprotiline; Middle Aged | 1992 |
Pharmacokinetics of the antidepressant levoprotiline after intravenous and peroral administration in healthy volunteers.
Topics: Administration, Oral; Adult; Antidepressive Agents; Biological Availability; Biotransformation; Female; Half-Life; Humans; Injections, Intravenous; Male; Maprotiline | 1992 |
[Psychopathologic and psychophysiologic follow-up of inpatient depressed patients with standardized treatment with clomipramine and oxaprotiline].
Topics: Adult; Antidepressive Agents; Arousal; Clomipramine; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Galvanic Skin Response; Habituation, Psychophysiologic; Hospitalization; Humans; Male; Maprotiline; Middle Aged; Personality Tests; Psychometrics | 1991 |
Pharmaco-EEG profile of levoprotiline: second example to discuss the predictive value of pharmaco-electroencephalography in early human pharmacological evaluations of psychoactive drugs.
Topics: Adult; Antidepressive Agents; Double-Blind Method; Electroencephalography; Humans; Imipramine; Male; Maprotiline | 1991 |
CGP 12.103 A versus clomipramine in the treatment of depressed inpatients--results of a double-blind study.
Topics: Anthracenes; Antidepressive Agents; Blood Pressure; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Maprotiline; Middle Aged; Psychiatric Status Rating Scales; Pulse; Random Allocation | 1988 |
Serotonin reuptake inhibition vs. norepinephrine reuptake inhibition: a double-blind differential-therapeutic study with fluvoxamine and oxaprotiline in endogenous and neurotic depressives.
Topics: Adult; Aged; Anthracenes; Antidepressive Agents; Depressive Disorder; Dexamethasone; Female; Fluvoxamine; Humans; Hydrocortisone; Male; Maprotiline; Middle Aged; Norepinephrine; Oximes; Prognosis; Psychiatric Status Rating Scales; Serotonin | 1987 |
Treatment strategy in depression. I. Non-tricyclic and selective reuptake inhibitors in resistant depression: a double-blind partial crossover study on the effects of oxaprotiline and fluvoxamine.
Topics: Adult; Anthracenes; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Fluvoxamine; Humans; Male; Maprotiline; Middle Aged; Oximes; Personality Disorders; Psychological Tests; Psychometrics | 1988 |
Treatment strategy in depression. II. MAO inhibitors in depression resistant to cyclic antidepressants: two controlled crossover studies with tranylcypromine versus L-5-hydroxytryptophan and nomifensine.
Topics: 5-Hydroxytryptophan; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Female; Fluvoxamine; Humans; Male; Maprotiline; Middle Aged; Nomifensine; Oximes; Psychological Tests; Tranylcypromine | 1988 |
Antidepressant plasma levels and clinical response in depressed patients treated with oxaprotiline and doxepin.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Doxepin; Female; Humans; Male; Maprotiline; Middle Aged; Psychiatric Status Rating Scales | 1988 |
Double-blind study of oxaprotiline versus clomipramine in the treatment of depressive inpatients.
Topics: Adult; Aged; Anthracenes; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Maprotiline; Middle Aged; Psychiatric Status Rating Scales | 1987 |
Amitriptyline and oxaprotiline in the treatment of hospitalized depressive patients. Clinical aspects, psychophysiology, and drug plasma levels.
Topics: Amitriptyline; Anthracenes; Antidepressive Agents; Arousal; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Maprotiline; Methoxyhydroxyphenylglycol; Middle Aged; Prognosis; Psychological Tests; Psychopathology | 1986 |
The dexamethasone suppression test and response to placebo.
Topics: 1-Naphthylamine; Clinical Trials as Topic; Depressive Disorder; Dexamethasone; Double-Blind Method; Humans; Maprotiline; Placebos; Sertraline | 1986 |
[Changes in slow evoked potentials in depressed patients treated with amitriptyline and oxaprotiline].
Topics: Adult; Amitriptyline; Anthracenes; Antidepressive Agents; Contingent Negative Variation; Depressive Disorder; Double-Blind Method; Electrophysiology; Evoked Potentials, Auditory; Female; Humans; Male; Maprotiline; Middle Aged; Nortriptyline; Random Allocation | 1987 |
Oxaprotiline in the treatment of endogenous depressed inpatients an early clinical trial.
Topics: Adult; Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Electroencephalography; Female; Humans; Male; Maprotiline; Middle Aged; Psychiatric Status Rating Scales | 1985 |
Clinical studies of the effect of (+) and (-)-oxaprotiline upon noradrenaline uptake.
Topics: Anthracenes; Antidepressive Agents; Desipramine; Humans; Male; Maprotiline; Melatonin; Norepinephrine; Pupil; Stereoisomerism | 1985 |
L-5HTP in depression resistant to re-uptake inhibitors. An open comparative study with tranylcypromine.
Topics: 5-Hydroxytryptophan; Adult; Aged; Carbidopa; Clinical Trials as Topic; Depressive Disorder; Drug Resistance; Drug Therapy, Combination; Fluvoxamine; Follow-Up Studies; Humans; Maprotiline; Middle Aged; Oximes; Random Allocation; Serotonin Antagonists; Stereoisomerism; Tranylcypromine | 1985 |
Second-generation antidepressants.
Topics: Alprazolam; Amoxapine; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trials as Topic; Dopamine; Double-Blind Method; Humans; Maprotiline; Nomifensine; Norepinephrine; Propiophenones; Propylamines; Seizures; Serotonin; Trazodone; Zimeldine | 1984 |
[The Eppendorf Mood and Motivation Scale as assessment procedure in the clinical evaluation of an antidepressive agent].
Topics: Affect; Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Maprotiline; Motivation; Psychiatric Status Rating Scales; Psychometrics; Sleep Stages | 1982 |
Differences of sympathomimetic and anticholinergic action of OH-maprotiline and its R (-)-enantiomer.
Topics: Adult; Anthracenes; Blood Pressure; Catecholamines; Heart Rate; Humans; Male; Maprotiline; Parasympatholytics; Pupil; Salivation; Stereoisomerism; Sympathomimetics; Time Factors | 1982 |
Predicting therapeutic results with levoprotiline and maprotiline in major depression: the role of the outcome criteria.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Female; Hospitalization; Humans; Male; Maprotiline; Middle Aged; Placebos; Probability; Treatment Outcome | 1993 |
Not significantly different is not the same as significantly similar.
Topics: Amitriptyline; Antidepressive Agents; Data Interpretation, Statistical; Depressive Disorder; Humans; Maprotiline; Norepinephrine | 1993 |
Dynamics of the effects of levoprotiline and maprotiline on EEG in patients with major depressive episodes (DSM-III-R).
Topics: Adult; Antidepressive Agents; Depressive Disorder; Electroencephalography; Female; Humans; Male; Maprotiline; Middle Aged | 1993 |
Differential effects of the enantiomers R(-) and S(+) oxaprotiline on major endogenous depression, the sleep EEG and neuroendocrine secretion: studies on depressed patients and normal controls.
Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Electroencephalography; Female; Growth Hormone; Humans; Hydrocortisone; Male; Maprotiline; Middle Aged; Neurosecretion; Norepinephrine; Penile Erection; Prolactin; Psychiatric Status Rating Scales; Sleep; Sleep, REM; Stereoisomerism; Testosterone | 1993 |
Time course of improvement under antidepressant treatment: a survival-analytical approach.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analysis of Variance; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Maprotiline; Middle Aged; Models, Statistical; Psychiatric Status Rating Scales; Single-Blind Method; Time Factors | 1993 |
Oxaprotiline: enantioselective noradrenaline uptake inhibition indicated by intravenous amine pressor tests but not alpha 2-adrenoceptor binding to intact platelets in man.
Topics: Adult; Antidepressive Agents; Blood Platelets; Blood Pressure; Depression, Chemical; Female; Humans; In Vitro Techniques; Male; Maprotiline; Norepinephrine; Protein Binding; Receptors, Adrenergic, alpha; Single-Blind Method; Stereoisomerism; Tyramine | 1993 |
A clinical test of noradrenergic involvement in the therapeutic mode of action of an experimental antidepressant.
Topics: Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Maprotiline; Norepinephrine; Psychiatric Status Rating Scales | 1993 |
Recovery from depression: triggers and time patterns.
Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Drug Administration Schedule; Humans; Maprotiline; Personality Inventory; Psychometrics; Survival Analysis; Time Factors; Treatment Outcome | 1996 |
72 other study(ies) available for hydroxymaprotilin and maprotiline
| Article | Year |
|---|---|
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Repeated treatment with levoprotiline, a novel antidepressant, up-regulates histamine H1 receptors and phosphoinositide hydrolysis response in vivo.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Histamine; Hydrolysis; Inositol Phosphates; Male; Maprotiline; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Histamine H1; Receptors, Muscarinic; Up-Regulation | 1992 |
The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking.
Topics: Aggression; Animals; Antidepressive Agents; Binding, Competitive; Cattle; Dose-Response Relationship, Drug; Histamine H1 Antagonists; In Vitro Techniques; Maprotiline; Olfactory Bulb; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Histamine H1 | 1992 |
The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells. Deamplification by isoproterenol and oxaprotiline.
Topics: Adenylyl Cyclases; Animals; Antidepressive Agents; Autoradiography; Blotting, Northern; Brain Neoplasms; Cells, Cultured; DNA Probes; Glioma; Guanylyl Imidodiphosphate; Isoproterenol; Maprotiline; Rats; Receptors, Adrenergic, beta; Regression Analysis; RNA; Tumor Cells, Cultured | 1992 |
The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist.
Topics: Animals; Antidepressive Agents; Benzazepines; Citalopram; Dizocilpine Maleate; Fluoxetine; Imipramine; Isomerism; Male; Maprotiline; Motor Activity; Prazosin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Sulpiride | 1992 |
Pharmacological profile of the new antidepressant levoprotiline.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Coagulation; Blood Glucose; Cardiovascular System; Dogs; Electroencephalography; Female; Heart; Hemolysis; Ileum; Lipids; Male; Maprotiline; Mice; Mice, Inbred Strains; Muscle, Smooth; Physostigmine; Rabbits; Rats; Rats, Wistar; Respiratory System; Urodynamics | 1992 |
Actions of oxaprotiline in the rat hippocampal slice.
Topics: Action Potentials; Animals; Antidepressive Agents; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Maprotiline; Rats; Rats, Inbred Strains; Stereoisomerism; Time Factors | 1992 |
Possible contributory role of the central histaminergic system in the forced swimming model.
Topics: Animals; Antidepressive Agents; Brain Chemistry; Central Nervous System; Depressive Disorder; Disease Models, Animal; Histamine; Male; Maprotiline; Methylhistamines; Mice; Motor Activity; Pyrilamine; Swimming | 1992 |
The noradrenaline uptake inhibitor, (+)-oxaprotiline, but not the inactive enantiomer, (-)-oxaprotiline, inhibits sympathetic nerve activity in the rabbit: involvement of adrenoceptors.
Topics: Animals; Blood Pressure; Clonidine; Drug Interactions; Ganglia, Sympathetic; Heart Rate; Kidney; Maprotiline; Neurotransmitter Uptake Inhibitors; Norepinephrine; Prazosin; Propranolol; Rabbits; Receptors, Adrenergic, alpha; Stereoisomerism; Sympathetic Nervous System; Yohimbine | 1991 |
Oxaprotiline enantiomers stimulate ACTH and corticosterone secretion in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Benzylamines; Corticosterone; Dexamethasone; Diazepam; Dose-Response Relationship, Drug; Male; Maprotiline; Metergoline; Naloxone; Piperidines; Pyrimidines; Radioimmunoassay; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stereoisomerism; Sulpiride; Sympathomimetics | 1991 |
Molecular aspects of the neuronal noradrenaline transporter.
Topics: Adrenal Medulla; Animals; Carrier Proteins; Cattle; Cell Membrane; Chromatography, Affinity; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Desipramine; Iprindole; Maprotiline; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Oocytes; PC12 Cells; Poly A; RNA; RNA, Messenger; Symporters; Xenopus laevis | 1991 |
[3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding.
Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Fluoxetine; Kinetics; Male; Maprotiline; Norepinephrine; Oxidopamine; Radioligand Assay; Rats; Rats, Inbred Strains; Stereoisomerism; Tritium | 1992 |
The effect of (+)- and (-)-oxaprotiline administered repeatedly on the dopamine system.
Topics: Animals; Antidepressive Agents; Apomorphine; Benzazepines; Dextroamphetamine; Exploratory Behavior; Male; Maprotiline; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism; Stereotyped Behavior; Swimming | 1991 |
Determination of the antidepressant levoprotiline and its N-desmethyl metabolite in biological fluids by gas chromatography/mass spectrometry.
Topics: Antidepressive Agents; Gas Chromatography-Mass Spectrometry; Maprotiline; Plasma | 1991 |
cAMP binding proteins in the rat cerebral cortex after administration of selective 5-HT and NE reuptake blockers with antidepressant activity.
Topics: Affinity Labels; Animals; Azides; Cerebral Cortex; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Fluoxetine; Male; Maprotiline; Microtubules; Molecular Weight; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Cyclic AMP; Serotonin Antagonists; Stereoisomerism | 1991 |
Levoprotiline ((-)-oxaprotiline) effects on inositol phosphate generation in human peripheral lymphocytes.
Topics: Antidepressive Agents; Humans; Inositol Phosphates; Lymphocyte Activation; Lymphocytes; Maprotiline; Membrane Lipids; N-Formylmethionine Leucyl-Phenylalanine; Second Messenger Systems | 1991 |
Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals.
Topics: Animals; Caudate Nucleus; Desipramine; Dopamine; Drug Synergism; Extracellular Space; Frontal Lobe; Haloperidol; Hydroxydopamines; Male; Maprotiline; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains | 1990 |
Oxaprotiline enantiomers given repeatedly and brain alpha-adrenoceptors.
Topics: Animals; Anthracenes; Brain; Exploratory Behavior; Male; Maprotiline; Mice; Motor Activity; Neurotransmitter Uptake Inhibitors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism | 1990 |
Some central pharmacological effects of (+)- and (-)-oxaprotiline.
Topics: Animals; Anthracenes; Apomorphine; Behavior, Animal; Clonidine; Dopamine; Hypothermia; Male; Maprotiline; Mice; Motor Activity; Rats; Rats, Inbred Strains; Reserpine; Stereoisomerism | 1990 |
Neuronal sensitivity to substance P is increased after repeated treatment with tranylcypromine, carbamazepine or oxaprotaline, but decreased after repeated electroconvulsive shock.
Topics: Animals; Anthracenes; Antidepressive Agents; Carbamazepine; Cerebral Cortex; Electroshock; Gyrus Cinguli; Iontophoresis; Male; Maprotiline; Neurons; Rats; Substance P; Tranylcypromine | 1985 |
A rapid and sensitive method for the quantitation of levoprotiline in human blood and plasma.
Topics: Antidepressive Agents; Chromatography, High Pressure Liquid; Humans; Injections, Intravenous; Maprotiline; Reference Standards; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1989 |
The influence of repeated treatment with imipramine, (+)- and (-)-oxaprotiline on behavioural effects of dopamine D-1 and D-2 agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anthracenes; Antidepressive Agents; Benzazepines; Dopamine Agents; Drug Interactions; Ergolines; Grooming; Imipramine; Male; Maprotiline; Motor Activity; Nucleus Accumbens; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reference Values; Stereoisomerism | 1989 |
Antidepressant drugs potentiate the alpha 1-adrenoceptor effect in hippocampal slices.
Topics: Animals; Antidepressive Agents; Hippocampus; Imipramine; In Vitro Techniques; Male; Maprotiline; Mianserin; Neurons; Neurotransmitter Agents; Norepinephrine; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
Comparative study of levoprotiline and amitriptyline in endogenous depressions.
Topics: Adult; Aged; Amitriptyline; Anthracenes; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Maprotiline; Middle Aged | 1989 |
Position of levoprotiline in the treatment of acute endogenous depression.
Topics: Adult; Anthracenes; Depressive Disorder; Female; Humans; Male; Maprotiline; Middle Aged | 1989 |
Levoprotiline--function regulator of food and satiety centres?
Topics: Adolescent; Adult; Anorexia Nervosa; Anthracenes; Antidepressive Agents; Bulimia; Dibenzothiepins; Dothiepin; Humans; Male; Maprotiline | 1989 |
Comparison of effect of levoprotiline and dosulepine on cardial functions.
Topics: Anthracenes; Antidepressive Agents; Cardiovascular Physiological Phenomena; Cardiovascular System; Double-Blind Method; Female; Humans; Male; Maprotiline; Middle Aged | 1989 |
Long term treatment with oxaprotiline in patients with major depression.
Topics: Adult; Aged; Anthracenes; Antidepressive Agents; Depressive Disorder; Female; Humans; Male; Maprotiline; Middle Aged; Psychiatric Status Rating Scales | 1989 |
Uptake, release, and modulation of release of noradrenaline in rabbit superior colliculus.
Topics: Animals; Clonidine; Electric Stimulation; Female; In Vitro Techniques; Male; Maprotiline; Norepinephrine; Rabbits; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Neurotransmitter; Serotonin; Superior Colliculi; Tetrodotoxin | 1988 |
Functional supersensitivity to the alpha 1-adrenoceptor agonist after repeated treatment with antidepressant drugs is not conditioned by beta-down-regulation.
Topics: Adrenergic alpha-Agonists; Animals; Antidepressive Agents; Brain Chemistry; Desipramine; Dihydroalprenolol; Male; Maprotiline; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1987 |
Effects of oxaprotiline on the response to peer separation in rhesus monkeys.
Topics: Affect; Animals; Anthracenes; Antidepressive Agents; Arousal; Behavior, Animal; Dose-Response Relationship, Drug; Macaca mulatta; Maprotiline; Motor Activity; Social Behavior; Social Environment; Stereotyped Behavior | 1989 |
Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT-receptor agonists.
Topics: Animals; Clonidine; Hippocampus; In Vitro Techniques; Maprotiline; Norepinephrine; Phentolamine; Rabbits; Receptors, Adrenergic, alpha; Serotonin; Yohimbine | 1985 |
Antidepressant-like effects of (+)-oxaprotiline on a behavioral screen.
Topics: Animals; Anthracenes; Antidepressive Agents; Discrimination Learning; Male; Maprotiline; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1988 |
Stereospecific immuno-recognition of the tetracyclic anti-depressant oxaprotiline.
Topics: Animals; Anthracenes; Antibodies; Antibodies, Monoclonal; Antibody Affinity; Antidepressive Agents; Antigen-Antibody Reactions; Maprotiline; Mice; Mice, Inbred BALB C; Models, Molecular; Rabbits; Stereoisomerism; Structure-Activity Relationship | 1988 |
Characterization of the inhibitory effect of some antidepressant drugs on the outward transport of norepinephrine in the ischemic myocardium.
Topics: Animals; Antidepressive Agents; Biological Transport, Active; Chromatography, High Pressure Liquid; Clonidine; Coronary Disease; Desipramine; Fluoxetine; Heart; Isomerism; Lidocaine; Male; Maprotiline; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains | 1988 |
Single treatments with the antidepressant oxaprotiline and its (+) and (-) enantiomers increase behavioural responses to dopaminergic stimulation in the rat.
Topics: Animals; Anthracenes; Antidepressive Agents; Apomorphine; Dextroamphetamine; Male; Maprotiline; Rats; Rats, Inbred Strains; Stereoisomerism; Stereotyped Behavior | 1988 |
The influence of oxaprotiline enantiomers given repeatedly on the behavioural effects of d-amphetamine and dopamine injected into the nucleus accumbens.
Topics: Animals; Anthracenes; Antidepressive Agents; Dextroamphetamine; Dopamine; Drug Administration Schedule; Exploratory Behavior; Isomerism; Locomotion; Male; Maprotiline; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei | 1988 |
Fluorimetric determination of levoprotiline in human plasma after thin-layer chromatographic or high performance liquid chromatographic separation.
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Maprotiline; Spectrometry, Fluorescence | 1987 |
Depression and sleep disorders. The optical isomers of oxaprotiline and their effect on sleep parameters in healthy subjects.
Topics: Adult; Anthracenes; Depressive Disorder; Humans; Male; Maprotiline; Norepinephrine; Sleep; Sleep Wake Disorders; Sleep, REM | 1986 |
Psychophysiological aspects of depressive syndromes.
Topics: Adult; Amitriptyline; Arousal; Autonomic Nervous System; Depressive Disorder; Electroencephalography; Evoked Potentials, Auditory; Female; Galvanic Skin Response; Humans; Inhibition, Psychological; Male; Maprotiline; Middle Aged | 1987 |
Serotonin (5-HT) enhances hippocampal noradrenaline (NA) release: evidence for facilitatory 5-HT receptors within the CNS.
Topics: Animals; Biological Transport, Active; Electric Stimulation; Hippocampus; In Vitro Techniques; Indoles; Maprotiline; Norepinephrine; Rabbits; Receptors, Serotonin; Serotonin; Tropanes; Tropisetron | 1986 |
Biotransformation of oxaprotiline: isolation and identification of metabolites in urine of rat and dog.
Topics: Animals; Anthracenes; Biotransformation; Dogs; Magnetic Resonance Spectroscopy; Maprotiline; Mass Spectrometry; Rats | 1986 |
Isolation and identification of hydroxylated maprotiline metabolites.
Topics: Animals; Anthracenes; Dogs; Female; Humans; Hydroxylation; Male; Maprotiline; Rabbits; Rats | 1985 |
Suppressant effect of REM sleep deprivation on neophobia in normal rats and in rats with selective DSP-4 induced damage of locus coeruleus neurons.
Topics: Animals; Anthracenes; Antidepressive Agents; Benzylamines; Fear; Locus Coeruleus; Male; Maprotiline; Norepinephrine; Rats; Sleep Deprivation; Sleep, REM | 1985 |
(+)-Oxaprotiline but not (-)-oxaprotiline given chronically potentiates the aggressive behaviour induced by clonidine.
Topics: Aggression; Animals; Anthracenes; Antidepressive Agents; Clonidine; Drug Synergism; Humans; Isomerism; Male; Maprotiline; Mice | 1983 |
The effects of single and repeated doses of maprotiline, oxaprotiline and its enantiomers on foot-shock induced fighting in rats.
Topics: Aggression; Animals; Anthracenes; Atropine; Cerebral Cortex; Electroshock; Humans; Male; Maprotiline; Norepinephrine; Promethazine; Rats; Stereoisomerism; Tyrosine 3-Monooxygenase | 1983 |
Stereospecificity of behavioural and biochemical responses to oxaprotiline--a new antidepressant.
Topics: Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Brain; Cyclic AMP; Male; Maprotiline; Mice; Neurons; Norepinephrine; Rats; Stereoisomerism | 1982 |
Oxaprotiline: induction of central noradrenergic subsensitivity of its (+)-enantiomer.
Topics: Animals; Anthracenes; Cerebral Cortex; Cyclic AMP; Desipramine; Dihydroalprenolol; In Vitro Techniques; Male; Maprotiline; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Stereoisomerism; Synaptosomes; Time Factors | 1982 |
The metabolic fate of [14C]oxaprotiline.HCl in man. I. Disposition and preliminary pharmacokinetics.
Topics: Administration, Oral; Anthracenes; Antidepressive Agents; Biotransformation; Blood Proteins; Humans; Intestinal Absorption; Kinetics; Male; Maprotiline; Middle Aged | 1984 |
The metabolic fate of [14C]oxaprotiline.HCl in man. II. Isolation and identification of metabolites.
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Humans; Kinetics; Male; Maprotiline; Middle Aged; Stereoisomerism | 1984 |
Measurement of maprotiline and oxaprotiline in plasma by high-performance liquid chromatography of fluorescent derivatives.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dansyl Compounds; Humans; Maprotiline; Spectrometry, Fluorescence | 1984 |
[Biochemical, pharmacologic and psychophysiologic studies for the optimization of drug therapy in depressive illnesses].
Topics: Amitriptyline; Antidepressive Agents; Arousal; Depressive Disorder; Double-Blind Method; Electroencephalography; Evoked Potentials; Glycols; Humans; Maprotiline; Methoxyhydroxyphenylglycol | 1984 |
Multiple inverse isotope dilution assay for the stereospecific quantitative determination of R(-) and S(+)-oxaprotiline in biological fluids.
Topics: Animals; Anthracenes; Chromatography, High Pressure Liquid; Male; Maprotiline; Radioisotope Dilution Technique; Rats; Stereoisomerism | 1982 |
Oxaprotiline, a noradrenaline uptake inhibitor with an active and an inactive enantiomer.
Topics: Animals; Anthracenes; Brain; Electric Stimulation; Female; Maprotiline; Membranes; Molecular Conformation; Myocardium; Norepinephrine; Prazosin; Rats; Serotonin; Stereoisomerism; Synaptosomes; Tyramine | 1982 |
Quantitative high-performance liquid chromatographic assay for the determination of maprotiline and oxaprotiline in human plasma.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Depression; Humans; Maprotiline | 1981 |
Involvement of monoamine uptake inhibition and local anesthesia in the cardiovascular response to cocaine in conscious rabbits.
Topics: Anesthetics, Local; Animals; Blood Pressure; Cocaine; Electric Stimulation; Fluvoxamine; Heart Rate; Lidocaine; Maprotiline; Procaine; Rabbits; Sympathetic Nervous System | 1995 |
Effect of some stereoisomeric tricyclic antidepressants on 45Ca uptake in synaptosomes from rat hippocampus.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Calcium; Calcium Channels; Calcium Radioisotopes; Doxepin; Hippocampus; In Vitro Techniques; Male; Maprotiline; Rats; Rats, Sprague-Dawley; Sodium; Stereoisomerism; Synaptosomes; Trimipramine | 1993 |
Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain.
Topics: Animals; Antidepressive Agents; Binding Sites; Brain; Citalopram; Fluoxetine; Ketanserin; Male; Maprotiline; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin | 1994 |
Inhibition of uptake 1 by (+)-oxaprotiline reveals a differential central regulation of noradrenaline and adrenaline release.
Topics: Anesthesia; Animals; Antidepressive Agents; Blood Pressure; Dose-Response Relationship, Drug; Epinephrine; Female; Heart Rate; Kinetics; Male; Maprotiline; Norepinephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha-2 | 1993 |
Endogenous noradrenaline activates alpha 2-adrenoceptors on serotonergic nerve endings in human and rat neocortex.
Topics: Action Potentials; Adult; Aged; Animals; Cerebral Cortex; Cold Temperature; Electric Stimulation; Exocytosis; Female; Humans; In Vitro Techniques; Male; Maprotiline; Middle Aged; Nerve Endings; Norepinephrine; Phentolamine; Rats; Receptors, Adrenergic, alpha; Serotonin; Yohimbine | 1993 |
Cerebral cortex injury: effect of blockers of re-uptake of catecholamines.
Topics: Animals; Catecholamines; Cerebral Cortex; Cholecystokinin; Male; Maprotiline; Neurotransmitter Uptake Inhibitors; Nomifensine; Protein Precursors; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; RNA, Messenger; Sympathetic Nervous System | 1993 |
Subtype determination of soma-dendritic alpha2-autoreceptors in slices of rat locus coeruleus.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Brimonidine Tartrate; Dendrites; In Vitro Techniques; Locus Coeruleus; Maprotiline; Neurons; Norepinephrine; Phentolamine; Prazosin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Yohimbine | 1997 |
Repeated administration of antidepressant drugs affects the levels of mRNA coding for D1 and D2 dopamine receptors in the rat brain.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain; Citalopram; Imipramine; Male; Maprotiline; Norepinephrine; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Selective Serotonin Reuptake Inhibitors | 1997 |
Increased synaptic availability of norepinephrine following desipramine is not essential for increases in GR mRNA. Short communication.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Desipramine; Male; Maprotiline; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; RNA, Messenger; Synapses | 1997 |
The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds.
Topics: Abdominal Muscles; Acetic Acid; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclobutanes; Dothiepin; Male; Maprotiline; Mice; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Neurotransmitter Uptake Inhibitors; Opioid Peptides; Pain Measurement; Paroxetine; Protease Inhibitors; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors; Thiorphan | 1998 |
Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds?
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclobutanes; Dothiepin; Drug Interactions; Male; Maprotiline; Mice; Norepinephrine; Pain Measurement; Paroxetine; Random Allocation; Receptors, Adrenergic; Selective Serotonin Reuptake Inhibitors | 1999 |
Differential effects of K(ATP) channel blockers on [(3)H]-noradrenaline overflow after short- and long-term exposure to (+)-oxaprotiline or desipramine.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Antidepressive Agents; Autoreceptors; Clonidine; Desipramine; Drug Interactions; Glyburide; In Vitro Techniques; Male; Maprotiline; Neocortex; Norepinephrine; Potassium Channel Blockers; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Time Factors | 2003 |
Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons.
Topics: Animals; Benzopyrans; Carbon Radioisotopes; Fluoxetine; Ligands; Maprotiline; Molecular Structure; Norepinephrine Plasma Membrane Transport Proteins; Papio; Positron-Emission Tomography; Stereoisomerism; Symporters | 2005 |
Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisox
Topics: Adrenergic Uptake Inhibitors; Animals; Autoradiography; Benzopyrans; Binding, Competitive; Brain; Brain Chemistry; Brain Mapping; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Evaluation Studies as Topic; Fluorine Radioisotopes; Fluoxetine; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Maprotiline; Mice; Morpholines; Nordefrin; Norepinephrine Plasma Membrane Transport Proteins; Papio; Positron-Emission Tomography; Protein Binding; Radioligand Assay; Reboxetine; Symporters; Time Factors; Tissue Distribution | 2005 |
Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adolescent; Adult; Aged; Alkaloids; Analysis of Variance; Animals; Autoreceptors; Azocines; Calcium; Child; Child, Preschool; Domperidone; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Feedback; Female; Fluvoxamine; Humans; In Vitro Techniques; Isoxazoles; Male; Maprotiline; Mice; Middle Aged; Neocortex; Nicotine; Nicotinic Antagonists; Potassium; Pyrrolidines; Quinolizines; Rats; Receptors, Nicotinic; Sulpiride; Time Factors; Tritium | 2006 |
Modulation of electrically evoked serotonin release in cultured rat raphe neurons.
Topics: Animals; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Electric Stimulation; Embryo, Mammalian; Female; Hydroxyindoleacetic Acid; Immunohistochemistry; Maprotiline; Nerve Tissue Proteins; Neurons; Pregnancy; Raphe Nuclei; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors; Tritium; Tryptophan Hydroxylase | 2007 |
Maintenance therapy with levoprotiline in anorexia nervosa and bulimia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Antidepressive Agents, Tricyclic; Body Weight; Bulimia Nervosa; Drug Tolerance; Female; Humans; Long-Term Care; Maprotiline; Psychiatric Status Rating Scales | 1991 |