Compounds > hydroxyl radical
Page last updated: 2024-09-04

hydroxyl radical and tamoxifen

hydroxyl radical has been researched along with tamoxifen in 6 studies

Compound Research Comparison

Studies
(hydroxyl radical)		Trials
(hydroxyl radical)		Recent Studies (post-2010)
(hydroxyl radical)		Studies
(tamoxifen)		Trials
(tamoxifen)		Recent Studies (post-2010) (tamoxifen)
10,147263,65720,6302,2276,256

Protein Interaction Comparison

ProteinTaxonomyhydroxyl radical (IC50)tamoxifen (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.46
Serine/threonine-protein kinase D3Homo sapiens (human)1
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)3.553
Estrogen receptorHomo sapiens (human)0.9266
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.949
Protein kinase C gamma typeHomo sapiens (human)1
Protein kinase C beta typeHomo sapiens (human)1
Tyrosine-protein kinase LckHomo sapiens (human)8.033
Tyrosine-protein kinase FynHomo sapiens (human)1.195
Progesterone receptorHomo sapiens (human)0.1288
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.472
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.793
Muscarinic acetylcholine receptor M4Homo sapiens (human)4.817
ATP-dependent translocase ABCB1Homo sapiens (human)6.4
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.585
Alpha-2A adrenergic receptorHomo sapiens (human)1.935
Adenosine receptor A3Homo sapiens (human)3.701
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.829
Steroid hormone receptor ERR1Homo sapiens (human)0.2
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.967
Beta-3 adrenergic receptorHomo sapiens (human)7.703
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.701
Protein kinase C alpha typeHomo sapiens (human)1
Alpha-2B adrenergic receptorHomo sapiens (human)3.518
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.974
Substance-K receptorHomo sapiens (human)3.67
D(1A) dopamine receptorHomo sapiens (human)8.502
Prostaglandin G/H synthase 1Homo sapiens (human)4.391
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.472
Thromboxane-A synthase Homo sapiens (human)0.916
Protein kinase C eta typeHomo sapiens (human)1
Histamine H2 receptorHomo sapiens (human)9.396
Alpha-1D adrenergic receptorHomo sapiens (human)4.982
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.801
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.46
Adenosine receptor A2aHomo sapiens (human)7.099
Sodium-dependent serotonin transporterHomo sapiens (human)2.334
D(3) dopamine receptorHomo sapiens (human)1.072
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.084
Protein kinase C iota typeHomo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.701
5-hydroxytryptamine receptor 6Homo sapiens (human)2.679
Estrogen-related receptor gammaHomo sapiens (human)0.0622
Sodium-dependent dopamine transporter Homo sapiens (human)1.841
Protein kinase C epsilon typeHomo sapiens (human)1
Protein kinase C theta typeHomo sapiens (human)1
Protein kinase C zeta typeHomo sapiens (human)1
Protein kinase C delta typeHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.2759
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.904
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)0.012
Serine/threonine-protein kinase D1Homo sapiens (human)1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.967
Estrogen receptor betaHomo sapiens (human)0.7809
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.021
7-dehydrocholesterol reductaseHomo sapiens (human)0.012

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Everman, DB; Fields, CE; Turner, MJ1
Clavère, P; Gardès-Albert, M; Jore, D; Leguéné, C1
Kubota, S; Obata, T1
Aliau, S; Bonnafous, JC; Borgna, JL; Mattras, H; Richard, E1
Obata, T1
Albright, CD; Appelbaum, JG; Ivanova, A; Salganik, RI; Sivashinski, MS; Wlassoff, WA1

Other Studies

6 other study(ies) available for hydroxyl radical and tamoxifen

ArticleYear
Evidence for superoxide formation during hepatic metabolism of tamoxifen.
    Biochemical pharmacology, 1991, Jun-01, Volume: 41, Issue:11

    Topics: Animals; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione Peroxidase; Hydroxides; Hydroxyl Radical; Liver; Male; Rats; Rats, Inbred F344; Superoxides; Tamoxifen

1991
[Radiolytic oxidation of tamoxifen with the free radicals OH- and/or HO2-].
    Canadian journal of physiology and pharmacology, 2001, Volume: 79, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Free Radical Scavengers; Gamma Rays; Hydrogen Peroxide; Hydroxyl Radical; Oxidation-Reduction; Pulse Radiolysis; Tamoxifen; Water

2001
Protective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum.
    Neuroscience letters, 2001, Aug-03, Volume: 308, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Hydroxyl Radical; Male; Microdialysis; Neostriatum; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinsonian Disorders; Rats; Rats, Wistar; Selective Estrogen Receptor Modulators; Tamoxifen

2001
Differential interactions of estrogens and antiestrogens at the 17 beta-hydroxyl or counterpart hydroxyl with histidine 524 of the human estrogen receptor alpha.
    Biochemistry, 2002, Jun-25, Volume: 41, Issue:25

    Topics: Alanine; Amino Acid Substitution; Animals; Binding Sites; COS Cells; Diethyl Pyrocarbonate; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Estrogens; Histidine; Humans; Hydroxyl Radical; Ligands; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen

2002
Tamoxifen protect against hydroxyl radical generation induced by phenelzine in rat striatum.
    Toxicology, 2006, May-01, Volume: 222, Issue:1-2

    Topics: 1-Methyl-4-phenylpyridinium; Amine Oxidase (Copper-Containing); Animals; Antidepressive Agents; Brain; Dopamine; Estrogen Antagonists; Herbicides; Hydroxyl Radical; Male; Neostriatum; Phenelzine; Rats; Rats, Wistar; Tamoxifen

2006
Hydrogen peroxide overproduced in breast cancer cells can serve as an anticancer prodrug generating apoptosis-stimulating hydroxyl radicals under the effect of tamoxifen-ferrocene conjugate.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:11

    Topics: Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; DNA Damage; Drug Delivery Systems; Female; Ferrous Compounds; Humans; Hydrogen Peroxide; Hydroxyl Radical; Metallocenes; Prodrugs; Reactive Oxygen Species; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured

2007