Page last updated: 2024-09-04

hydroxyl radical and sulfasalazine

hydroxyl radical has been researched along with sulfasalazine in 9 studies

Compound Research Comparison

Studies
(hydroxyl radical)
Trials
(hydroxyl radical)
Recent Studies (post-2010)
(hydroxyl radical)
Studies
(sulfasalazine)
Trials
(sulfasalazine)
Recent Studies (post-2010) (sulfasalazine)
10,147263,6574,437585938

Protein Interaction Comparison

ProteinTaxonomyhydroxyl radical (IC50)sulfasalazine (IC50)
Multidrug resistance-associated protein 4Homo sapiens (human)1.5
Solute carrier organic anion transporter family member 2B1 Homo sapiens (human)3
Carbonic anhydrase 1Homo sapiens (human)3.04
Carbonic anhydrase 2Homo sapiens (human)4.49
Mitogen-activated protein kinase 1Homo sapiens (human)6.332
Sodium/bile acid cotransporterHomo sapiens (human)9.6
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.46
Cystine/glutamate transporterHomo sapiens (human)0.16
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.56

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fehér, J; Láng, I; Prónai, L; Yukinobu, I1
Betts, WH; Cleland, LG; Vernon-Roberts, B; Whitehouse, MW1
Halliwell, B1
Aruoma, OI; Butler, J; Halliwell, B; Hoey, BM; Wasil, M1
Grisham, MB; Kvietys, PR; Manci, EA; Smith, SM1
Grisham, MB; Miles, AM1
Joshi, R; Kumar, S; Mukherjee, T; Unnikrishnan, M1
André, C; Gharbi, T; Guillaume, YC; Herlem, G; Ibrahim, F1
Fujiwara, K; Imaue, S; Jawaid, P; Kondo, T; Mitsuhashi, Y; Moniruzzaman, R; Noguchi, K; Noguchi, M; Ogawa, R; Rehman, MU; Saitoh, JI; Tomihara, K; Zhao, QL1

Other Studies

9 other study(ies) available for hydroxyl radical and sulfasalazine

ArticleYear
The oxygen-centered radicals scavenging activity of sulfasalazine and its metabolites. A direct protection of the bowel.
    Acta physiologica Hungarica, 1992, Volume: 80, Issue:1-4

    Topics: Free Radical Scavengers; Humans; Hydroxyl Radical; Inflammatory Bowel Diseases; Kinetics; Magnetic Resonance Spectroscopy; Oxygen Consumption; Spin Labels; Sulfasalazine; Superoxides

1992
In vitro antioxidant properties of potential biotransformation products of salicylate, sulphasalazine and amidopyrine.
    Journal of free radicals in biology & medicine, 1985, Volume: 1, Issue:4

    Topics: Aminopyrine; Antioxidants; Biotransformation; Free Radicals; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Luminescent Measurements; Phenols; Salicylates; Salicylic Acid; Structure-Activity Relationship; Sulfasalazine; Xanthine Oxidase

1985
Sulphasalazine and oxidant scavenging in ulcerative colitis.
    Lancet (London, England), 1987, Sep-12, Volume: 2, Issue:8559

    Topics: Colitis, Ulcerative; Humans; Hydroxides; Hydroxyl Radical; Neutrophils; Sulfasalazine

1987
The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects?
    Biochemical pharmacology, 1987, Nov-01, Volume: 36, Issue:21

    Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Hydroxides; Hydroxyl Radical; Hypochlorous Acid; Mesalamine; Oxidation-Reduction; Sulfanilamides; Sulfapyridine; Sulfasalazine

1987
5-Aminosalicylic acid protects against ischemia/reperfusion-induced gastric bleeding in the rat.
    Gastroenterology, 1988, Volume: 94, Issue:3

    Topics: Aminosalicylic Acids; Animals; Dimethyl Sulfoxide; Gastrointestinal Hemorrhage; Hydroxides; Hydroxyl Radical; Ischemia; Male; Mesalamine; Rats; Rats, Inbred Strains; Stomach; Stomach Diseases; Sulfasalazine

1988
Antioxidant properties of aminosalicylates.
    Methods in enzymology, 1994, Volume: 234

    Topics: Aminosalicylic Acids; Antioxidants; Erythrocytes; Free Radicals; Humans; Hydrogen Peroxide; Hydroxyl Radical; Indicators and Reagents; Neutrophils; Peroxides; Reactive Oxygen Species; Spectrophotometry; Spectrophotometry, Ultraviolet; Sulfapyridine; Sulfasalazine; Superoxides; Thiobarbituric Acid Reactive Substances

1994
Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: mechanistic aspects and antioxidant activity.
    Free radical research, 2005, Volume: 39, Issue:11

    Topics: Aminosalicylic Acids; Anions; Antioxidants; Electrons; Free Radical Scavengers; Free Radicals; Glutathione; Hydrogen-Ion Concentration; Hydroxyl Radical; Inflammation; Inflammatory Bowel Diseases; Kinetics; Lipid Peroxidation; Mesalamine; Models, Chemical; Oxygen; Peroxides; Pulse Radiolysis; Spectrophotometry; Sulfapyridine; Sulfasalazine; Time Factors

2005
Experimental studies of OH° radical/pressure dependence of arginase activity using a molecular chromatography approach.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Oct-15, Volume: 878, Issue:28

    Topics: Animals; Arginase; Bioreactors; Cattle; Chromatography, High Pressure Liquid; Enzymes, Immobilized; Hydroxyl Radical; Kinetics; Pressure; Sulfasalazine

2010
Roles of intracellular and extracellular ROS formation in apoptosis induced by cold atmospheric helium plasma and X-irradiation in the presence of sulfasalazine.
    Free radical biology & medicine, 2018, Volume: 129

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Calcium; Caspase 3; Caspase 8; Cations, Divalent; Cell Line, Tumor; Cell Survival; DNA Fragmentation; fas Receptor; Gene Expression Regulation; HCT116 Cells; Helium; Humans; Hydroxyl Radical; Membrane Potential, Mitochondrial; Mitochondria; Oxidants; Oxidative Stress; Plasma Gases; Signal Transduction; Sulfasalazine; T-Lymphocytes; X-Rays

2018