hydroxyl radical has been researched along with selegiline in 17 studies
| Studies (hydroxyl radical) | Trials (hydroxyl radical) | Recent Studies (post-2010) (hydroxyl radical) | Studies (selegiline) | Trials (selegiline) | Recent Studies (post-2010) (selegiline) |
|---|---|---|---|---|---|
| 10,147 | 26 | 3,657 | 2,575 | 319 | 394 |
| Protein | Taxonomy | hydroxyl radical (IC50) | selegiline (IC50) |
|---|---|---|---|
| Cholinesterase | Homo sapiens (human) | 0.0055 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.0039 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 1.798 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.376 | |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 0.2127 | |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | 0.9046 | |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | 1.4408 | |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | 0.0067 | |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | 0.1001 | |
| Type-1 angiotensin II receptor | Sus scrofa (pig) | 0.048 | |
| Alpha-synuclein | Homo sapiens (human) | 0.27 | |
| Amine oxidase [flavin-containing] B | Bos taurus (cattle) | 1 | |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | 0.017 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 12 (70.59) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiueh, CC; Huang, SJ; Murphy, DL | 2 |
| Cohen, G | 1 |
| Boulu, RG; Callebert, J; Lancelot, E; Plotkine, M | 1 |
| Chiueh, CC; Mohanakumar, KP; Murphy, DL; Wu, RM | 1 |
| Chiueh, CC; Krishna, G; Mohanakumar, KP; Murphy, DL; Obata, T; Sternberger, LM; Wu, RM | 1 |
| Bennett, JP; Parker, WD; Smith, TS | 1 |
| Chiueh, CC; Murphy, DL; Pert, A; Wu, RM | 1 |
| Chiueh, CC; Murphy, DL; Wu, RM | 1 |
| Boismenu, D; Mamer, O; Montgomery, J; Ste-Marie, L; Vachon, L | 1 |
| Huber, EW; Ohlweiler, DF; Thomas, CE | 1 |
| Ferger, B; Kuschinsky, K; Seyfried, C; van Amsterdam, C | 1 |
| Bémeur, C; Lambert, J; Montgomery, J; Ste-Marie, L; Vachon, L | 1 |
| Acuña-Castroviejo, D; Escames, G; Khaldy, H; León, J; Luna, JD; Vives, F | 1 |
| Atiki, L; Cano, J; Machado, A; Revuelta, M; Santiago, M; Toms-Camardiel, MC; Venero, JL | 1 |
| Mohanakumar, KP; Muralikrishnan, D; Samantaray, S | 1 |
| Mohanakumar, KP; Saravanan, KS; Senthilkumar, KS; Sindhu, KM | 1 |
2 review(s) available for hydroxyl radical and selegiline
| Article | Year |
|---|---|
Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline).
Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Animals; Antioxidants; Corpus Striatum; Free Radicals; Humans; Hydroxyl Radical; Lipid Peroxidation; Monoamine Oxidase; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra | 1994 |
In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia.
Topics: Animals; Antioxidants; Basal Ganglia; Corpus Striatum; Dopamine; Free Radical Scavengers; Free Radicals; Humans; Hydroxyl Radical; Melanins; MPTP Poisoning; Nerve Degeneration; Parkinson Disease; Rats; Salicylates; Selegiline; Substantia Nigra | 1994 |
15 other study(ies) available for hydroxyl radical and selegiline
| Article | Year |
|---|---|
Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clorgyline; Dialysis; Free Radicals; Hydroxides; Hydroxyl Radical; Rats; Selegiline | 1992 |
The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence.
Topics: Animals; Brain; Catalase; Catecholamines; Dopamine; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Levodopa; Monoamine Oxidase; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Selegiline; Superoxide Dismutase; Superoxides | 1983 |
Striatal dopamine participates in glutamate-induced hydroxyl radical generation.
Topics: Animals; Clorgyline; Dopamine; Glutamic Acid; Hydroxyl Radical; Male; Microdialysis; Neostriatum; Rats; Rats, Sprague-Dawley; Salicylates; Selegiline | 1995 |
Suppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuroprotective mechanism in dopaminergic neurotoxicity.
Topics: Ascorbic Acid; Clorgyline; Dopamine; Dopamine Agents; Dopamine Antagonists; Hydroxyl Radical; Melanins; Monoamine Oxidase Inhibitors; Nervous System; Oxidation-Reduction; Pargyline; Selegiline | 1994 |
L-dopa increases nigral production of hydroxyl radicals in vivo: potential L-dopa toxicity?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Acid; Hydroxyl Radical; Levodopa; Microdialysis; Mitochondria; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Selegiline; Stereotaxic Techniques; Substantia Nigra | 1994 |
Apparent antioxidant effect of l-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Dopamine; Hydroxyl Radical; Male; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra | 1993 |
Suppression of hydroxyl radical formation and protection of nigral neurons by l-deprenyl (selegiline).
Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Dopamine; Hydroxyl Radical; Male; Neurons; Rats; Rats, Sprague-Dawley; Selegiline; Time Factors | 1996 |
In vivo hydroxylation of the neurotoxin, 1-methyl-4-phenylpyridinium, and the effect of monoamine oxidase inhibitors: electrospray-MS analysis of intra-striatal microdialysates.
Topics: 1-Methyl-4-phenylpyridinium; Allyl Compounds; Animals; Butylamines; Dopamine Agents; Hydroxyl Radical; Hydroxylation; Male; Mass Spectrometry; Microdialysis; Monoamine Oxidase Inhibitors; Neostriatum; Rats; Rats, Sprague-Dawley; Selegiline; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Hydroxyl and peroxyl radical trapping by the monoamine oxidase-B inhibitors deprenyl and MDL 72,974A: implications for protection of biological substrates.
Topics: Allyl Compounds; Antiparkinson Agents; Butylamines; Deoxyribose; Hydroxyl Radical; In Vitro Techniques; Lipid Peroxidation; Liposomes; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Oxidative Stress; Peroxides; Selegiline; Thiobarbituric Acid Reactive Substances | 1997 |
Effects of alpha-phenyl-tert-butylnitrone and selegiline on hydroxyl free radicals in rat striatum produced by local application of glutamate.
Topics: Administration, Topical; Animals; Corpus Striatum; Cyclic N-Oxides; Free Radical Scavengers; Gentisates; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Male; Microdialysis; Monoamine Oxidase Inhibitors; Nitrogen Oxides; Rats; Rats, Wistar; Selegiline | 1998 |
Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate.
Topics: 1-Methyl-4-phenylpyridinium; Allyl Compounds; Animals; Antioxidants; Butylamines; Corpus Striatum; Dopamine; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Injections, Intraperitoneal; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neurotoxins; Parabens; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline | 1999 |
Comparative effects of melatonin, L-deprenyl, Trolox and ascorbate in the suppression of hydroxyl radical formation during dopamine autoxidation in vitro.
Topics: Antioxidants; Ascorbic Acid; Chromans; Dopamine; Dose-Response Relationship, Drug; Hydroxybenzoates; Hydroxyl Radical; Iron; Melatonin; Oxidation-Reduction; Salicylates; Selegiline | 2000 |
Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy.
Topics: Animals; Axotomy; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Hydroxyl Radical; Immunohistochemistry; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Rats; Rats, Wistar; RNA, Messenger; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase | 2003 |
D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Isomerism; Mice; Mice, Inbred BALB C; Monoamine Oxidase; Neostriatum; Neural Pathways; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Selegiline; Substantia Nigra | 2003 |
L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats.
Topics: Amphetamine; Animals; Catalase; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Electron Transport Complex I; Hydroxyl Radical; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotenone; Selegiline; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase; Uncoupling Agents; Up-Regulation | 2006 |