hydroxyl radical has been researched along with oxidopamine in 36 studies
| Studies (hydroxyl radical) | Trials (hydroxyl radical) | Recent Studies (post-2010) (hydroxyl radical) | Studies (oxidopamine) | Trials (oxidopamine) | Recent Studies (post-2010) (oxidopamine) |
|---|---|---|---|---|---|
| 10,147 | 26 | 3,657 | 8,630 | 6 | 2,407 |
| Protein | Taxonomy | hydroxyl radical (IC50) | oxidopamine (IC50) |
|---|---|---|---|
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | 8 | |
| DNA repair protein RAD52 homolog | Homo sapiens (human) | 0.779 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.89) | 18.7374 |
| 1990's | 14 (38.89) | 18.2507 |
| 2000's | 11 (30.56) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cowan, DL; Oldfield, FF; Sun, AY | 1 |
| Davison, AJ; Gee, P | 2 |
| Cohen, G; Slivka, A | 1 |
| Cohen, G | 1 |
| Cohen, G; Heikkila, RE | 1 |
| Asanuma, M; Kawai, M; Kohno, M; Masumizu, T; Mori, A; Ogawa, N; Tanaka, K | 1 |
| Ben-Shachar, D; Eshel, G; Finberg, JP; Riederer, P; Youdim, MB | 1 |
| De Wit, LE; Gramsbergen, JB; Korf, J; Koster, JF; Sloot, WN | 1 |
| Correa, JG; Stoppani, AO | 1 |
| Memoli, S; Nappi, AJ; Prota, G; Vass, E | 1 |
| Herlinger, E; Jellinger, K; Kienzl, E; Linert, L; Youdim, MB | 1 |
| Mazziotti, M; Perlmutter, DH | 1 |
| Blunt, SB; Opacka-Juffry, J; Wilson, AW | 1 |
| Abin, JA; Costa, G; Dajas, F; Dajas-Bailador, FA; Martignoni, E; Martinez-Borges, A; Nappi, G | 1 |
| Burke, WJ; Ebadi, M; el-Sayed, MA; Folks, DG; Hiramatsu, M | 1 |
| Hironishi, M; Senba, E; Ueyama, E | 1 |
| de Groote, C; Eberhardt, O; Ferger, B; Schulz, JB; Teismann, P | 1 |
| Iwata-Ichikawa, E; Kabuto, H; Ogawa, N; Yokoi, I | 1 |
| Camp, DM; LeWitt, PA; Loeffler, DA | 1 |
| Borisenko, GG; Hsia, CJ; Kagan, VE; Schor, NF | 1 |
| Hashiguchi, H; Ishida, Y; Ishizuka, Y; Mitsuyama, Y; Todaka, K | 1 |
| Ferger, B; Mierau, J; Teismann, P | 1 |
| Ferger, B; Halliwell, B; Jenner, A; Jenner, P; Rose, S | 1 |
| Ferger, B; Kuschinsky, K; Teismann, P; Themann, C | 1 |
| Hermida-Ameijeiras, A; Labandeira-García, JL; López-Martín, ME; Méndez-Alvarez, E; Soto-Otero, R | 1 |
| Hermida-Ameijeiras, A; Labandeira-García, JL; López-Real, AM; Méndez-Alvarez, E; Soto-Otero, R | 1 |
| Higashio, C; Kabuto, H; Kohno, M; Nishizawa, M; Shishibori, T; Tada, M | 1 |
| Bar-Am, O; Fridkin, M; Gal, S; Warshawsky, A; Weiner, LM; Youdim, MB; Zheng, H | 1 |
| Wang, DQ; Wang, W; Zhao, DZ | 1 |
| Kostrzewa, RA; Kostrzewa, RM; Nowak, P; Skaba, D | 1 |
| Dziubina, A; Gołembiowska, K | 1 |
| Dong, FY; Peng, Y; Sun, YP; Tang, J; Xu, H; Yin, SM; Yu, DQ; Zhang, WQ | 1 |
| Ashihara, E; Inden, M; Kitamura, Y; Takata, K; Yasui, H; Yoshimoto, K | 1 |
| Bałasz, M; Brus, R; Kasperczyk, S; Kostrzewa, RM; Malinowska-Borowska, J; Nowak, D; Nowak, P; Szkilnik, R | 1 |
| Galisteo, J; Herraiz, T | 1 |
36 other study(ies) available for hydroxyl radical and oxidopamine
| Article | Year |
|---|---|
The involvement of ethanol in the free radical reaction of 6-hydroxydopamine.
Topics: Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Ethanol; Ferrous Compounds; Free Radicals; Glutathione; Hydrogen Peroxide; Hydroxides; Hydroxydopamines; Hydroxyl Radical; Lipid Peroxidation; Mannitol; Oxidopamine; Sodium-Potassium-Exchanging ATPase; Spin Labels; Vitamin E | 1991 |
Intermediates in the aerobic autoxidation of 6-hydroxydopamine: relative importance under different reaction conditions.
Topics: Aerobiosis; Catalase; Chemical Phenomena; Chemistry; Deferoxamine; Edetic Acid; Formates; Free Radicals; Glucose; Hydrogen Peroxide; Hydroxides; Hydroxydopamines; Hydroxyl Radical; Mannitol; Metals; Oxidation-Reduction; Oxidopamine; Pentetic Acid; Superoxide Dismutase; Superoxides | 1989 |
Hydroxyl radical attack on dopamine.
Topics: Ascorbic Acid; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dopamine; Edetic Acid; Hydroxides; Hydroxydopamines; Hydroxyl Radical; Oxidopamine | 1985 |
Monoamine oxidase, hydrogen peroxide, and Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Culture Techniques; Dopamine; Humans; Hydrogen Peroxide; Hydroxides; Hydroxydopamines; Hydroxyl Radical; Macaca fascicularis; Monoamine Oxidase; Neurons; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Superoxides | 1987 |
Redox state of cytochrome c in the presence of the 6-hydroxydopamine/oxygen couple: oscillations dependent on the presence of hydrogen peroxide or superoxide.
Topics: Chemical Phenomena; Chemistry; Cytochrome c Group; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxydopamines; Hydroxyl Radical; Mannitol; Metals; Oxidation-Reduction; Oxidopamine; Oxygen; Superoxides | 1984 |
Alloxan and 6-hydroxydopamine: cellular toxins.
Topics: Alloxan; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Free Radicals; Heart Atria; Hydroxides; Hydroxydopamines; Hydroxyl Radical; Insulin; Male; Myocardium; Norepinephrine; Oxidopamine; Radioimmunoassay; Sympathetic Nervous System; Tritium | 1984 |
Bromocriptine protects mice against 6-hydroxydopamine and scavenges hydroxyl free radicals in vitro.
Topics: Animals; Bromocriptine; Carbidopa; Corpus Striatum; Desipramine; Dopamine; Free Radical Scavengers; Hydroxyl Radical; Injections, Intraventricular; Levodopa; Male; Mice; Mice, Inbred ICR; Oxidopamine | 1994 |
The neurotoxicity of iron and nitric oxide. Relevance to the etiology of Parkinson's disease.
Topics: Animals; Deferoxamine; Dominance, Cerebral; Ferritins; Free Radicals; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Injections, Intraventricular; Iron; Lipid Peroxidation; Nitric Oxide; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Stereotyped Behavior; Substantia Nigra | 1993 |
Manganese-induced hydroxyl radical formation in rat striatum is not attenuated by dopamine depletion or iron chelation in vivo.
Topics: Animals; Corpus Striatum; Deferoxamine; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Iron; Iron Chelating Agents; Male; Manganese; Molecular Weight; Neurotoxins; Osmolar Concentration; Oxidopamine; Rats; Rats, Wistar; Reserpine; Time Factors | 1996 |
Catecholamines enhance dihydrolipoamide dehydrogenase inactivation by the copper Fenton system. Enzyme protection by copper chelators.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Captopril; Catecholamines; Catechols; Cattle; Chelating Agents; Copper; Cysteine; Dihydrolipoamide Dehydrogenase; Dopamine; Epinephrine; Hydrogen Peroxide; Hydroxyl Radical; Iron; Kinetics; Mammals; Norepinephrine; Oxidation-Reduction; Oxidopamine; Penicillamine | 1996 |
The effects of hydroxyl radical attack on dopa, dopamine, 6-hydroxydopa, and 6-hydroxydopamine.
Topics: Benzoquinones; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Hydroxyl Radical; Melanins; Models, Chemical; Oxidation-Reduction; Oxidopamine; Quinones | 1995 |
Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease.
Topics: Dopamine; Electron Transport; Ferric Compounds; Ferritins; Hydroxydopamines; Hydroxyl Radical; In Vitro Techniques; Kinetics; Molecular Structure; Neurotoxins; Oxidation-Reduction; Oxidopamine; Oxygen; Parkinson Disease; Spectrophotometry; Spectrophotometry, Ultraviolet | 1995 |
Resistance to the apoptotic effect of aggregated amyloid-beta peptide in several different cell types including neuronal- and hepatoma-derived cell lines.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antimycin A; Apoptosis; Cell Line; Cytotoxins; DNA Fragmentation; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydroxyl Radical; Nerve Growth Factors; Oxidative Stress; Oxidopamine; Peptide Fragments; Rats | 1998 |
Effects of pergolide treatment on in vivo hydroxyl free radical formation during infusion of 6-hydroxydopamine in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Dopamine; Free Radical Scavengers; Hydroxyl Radical; Injections; Male; Neostriatum; Oxidopamine; Pergolide; Rats; Rats, Sprague-Dawley; Sympatholytics | 1998 |
Hydroxyl radical production in the substantia nigra after 6-hydroxydopamine and hypoxia-reoxygenation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Hypoxia, Brain; Male; Neurotoxins; Oxidopamine; Oxygen; Partial Pressure; Rats; Rats, Sprague-Dawley; Salicylic Acid; Substantia Nigra | 1998 |
Metallothionein isoforms provide neuroprotection against 6-hydroxydopamine-generated hydroxyl radicals and superoxide anions.
Topics: Animals; Anions; Brain; Cells, Cultured; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxyl Radical; Metallothionein; Mice; Mitochondria; Neuroprotective Agents; Oxidopamine; Protein Isoforms; Spin Labels; Superoxides | 1998 |
Systematic expression of immediate early genes and intensive astrocyte activation induced by intrastriatal ferrous iron injection.
Topics: Animals; Astrocytes; Behavior, Animal; Coloring Agents; Corpus Striatum; Dopamine; Ferrocyanides; Ferrous Compounds; Genes, Immediate-Early; Geniculate Bodies; Hydroxyl Radical; Male; Microinjections; Oxidative Stress; Oxidopamine; Parkinson Disease, Secondary; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympatholytics | 1999 |
Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation.
Topics: Animals; Dizocilpine Maleate; Dopamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hydroxyl Radical; Male; Malonates; Microdialysis; Neostriatum; Oxidopamine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Succinate Dehydrogenase | 1999 |
EPC-K1, a hydroxyl radical scavenger, prevents 6-hydroxydopamine-induced dopamine depletion in the mouse striatum by up-regulation of catalase activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Ascorbic Acid; Catalase; Cerebral Ventricles; Corpus Striatum; Dopamine; Free Radical Scavengers; Glutathione; Homovanillic Acid; Hydroxyl Radical; Injections, Intraventricular; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Oxidopamine; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin E | 1999 |
L-DOPA does not enhance hydroxyl radical formation in the nigrostriatal dopamine system of rats with a unilateral 6-hydroxydopamine lesion.
Topics: Animals; Cerebellum; Corpus Striatum; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Injections; Levodopa; Male; Mesencephalon; Methamphetamine; Microdialysis; Osmolar Concentration; Oxidopamine; Rats; Rats, Sprague-Dawley; Salicylates; Substantia Nigra | 2000 |
Interaction between 6-hydroxydopamine and transferrin: "Let my iron go".
Topics: Animals; Ascorbic Acid; Behavior, Animal; Deferoxamine; Electron Spin Resonance Spectroscopy; Ferric Compounds; Ferrozine; Free Radicals; Humans; Hydroxyl Radical; Injections, Intraperitoneal; Iron; Iron Chelating Agents; Male; Mice; Mice, Inbred A; Oxidopamine; Transferrin | 2000 |
Repeated administration of high dose levodopa enhances hydroxyl radical production in the rat striatum denervated with 6-hydroxydopamine.
Topics: Animals; Corpus Striatum; Denervation; Drug Administration Schedule; Female; Hydroxyl Radical; Injections, Intraperitoneal; Levodopa; Oxidopamine; Rats; Rats, Wistar | 2000 |
The dopamine agonist pramipexole scavenges hydroxyl free radicals induced by striatal application of 6-hydroxydopamine in rats: an in vivo microdialysis study.
Topics: Adrenergic Agents; Animals; Benzothiazoles; Corpus Striatum; Dopamine; Dopamine Agonists; Hydroxybenzoates; Hydroxyl Radical; Male; Microdialysis; Oxidopamine; Pergolide; Pramipexole; Rats; Rats, Wistar; Thiazoles | 2000 |
6-hydroxydopamine increases hydroxyl free radical production and DNA damage in rat striatum.
Topics: Adrenergic Agents; Animals; Corpus Striatum; Cytosine; DNA Damage; Gas Chromatography-Mass Spectrometry; Hydroxybenzoates; Hydroxyl Radical; Hypoxanthine; Male; Oxidopamine; Rats; Rats, Wistar | 2001 |
Comparison of two independent aromatic hydroxylation assays in combination with intracerebral microdialysis to determine hydroxyl free radicals.
Topics: Animals; Biological Assay; Cerebral Cortex; Gentisates; Hydrocarbons, Aromatic; Hydroxyl Radical; Isomerism; Male; Microdialysis; Motor Activity; Neurons; Oxidative Stress; Oxidopamine; Phenylalanine; Rats; Rats, Wistar; Salicylic Acid; Sympatholytics | 2001 |
Effect of iron and manganese on hydroxyl radical production by 6-hydroxydopamine: mediation of antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Corpus Striatum; Cysteine; Female; Glutathione; Hydrogen Peroxide; Hydroxyl Radical; Iron; Manganese; Oxidation-Reduction; Oxidopamine; Rats; Rats, Sprague-Dawley | 2001 |
Effects of aluminum and zinc on the oxidative stress caused by 6-hydroxydopamine autoxidation: relevance for the pathogenesis of Parkinson's disease.
Topics: Adrenergic Agents; Aluminum; Animals; Antioxidants; Ascorbic Acid; Brain; Cations; Cysteine; Glutathione; Hydroxyl Radical; Male; Mitochondria; Oxidative Stress; Oxidopamine; Oxygen Consumption; Polarography; Rats; Rats, Sprague-Dawley; Spectrophotometry; Thiobarbituric Acid Reactive Substances; Zinc | 2002 |
Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catalase; Dopamine; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Glutathione Peroxidase; Guaiacol; Homovanillic Acid; Hydroxyl Radical; Male; Mice; Mice, Inbred ICR; Neostriatum; Nerve Tissue Proteins; Oxidopamine; Superoxides; Sympatholytics | 2005 |
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition.
Topics: Animals; Antioxidants; Cell Survival; Culture Media, Serum-Free; Cysteine; Designer Drugs; Hydroxyl Radical; Hydroxyquinolines; Iron Chelating Agents; Lipid Peroxidation; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Neuroprotective Agents; Oxidopamine; PC12 Cells; Piperazines; Rats | 2005 |
[Effect of prepared radix Polygoni multiflori on the elevation of extracellular hydroxyl radical in striatum of rats induced by intracerebral perfusion of 6-hydroxy dopamine].
Topics: Animals; Corpus Striatum; Drugs, Chinese Herbal; Hydroxyl Radical; Male; Microdialysis; Neuroprotective Agents; Oxidopamine; Polygonum; Random Allocation; Rats; Rats, Sprague-Dawley | 2006 |
Acute L: -DOPA effect on hydroxyl radical- and DOPAC-levels in striatal microdialysates of parkinsonian rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Female; Hydroxyindoleacetic Acid; Hydroxyl Radical; Injections, Intraventricular; Levodopa; Male; Microdialysis; Oxidopamine; Parkinsonian Disorders; Pregnancy; Rats; Sympatholytics; Time Factors | 2010 |
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles | 2012 |
[The reduced antioxidation ability in the serum in the early Parkinson's disease rats].
Topics: Animals; Disease Progression; Dopaminergic Neurons; Free Radical Scavengers; Hydroxyl Radical; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley | 2011 |
Detoxification of 6-hydroxydopamine-induced dopaminergic neurodegeneration by 5,5-dimethyl-1-pyrroline N-oxide, a radical trapper, in hemiparkinsonian rats.
Topics: Animals; Antioxidants; Behavior, Animal; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyl Radical; Iron; Male; Mental Disorders; Oxidative Stress; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase | 2012 |
Perinatal manganese exposure and hydroxyl radical formation in rat brain.
Topics: Animals; Brain; Brain Chemistry; Female; Frontal Lobe; Hippocampus; Hydroxyl Radical; Male; Manganese; Neostriatum; Oxidopamine; Parkinsonian Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2015 |
Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkaloids; Antioxidants; Ascorbic Acid; Carbolines; Chromatography, High Pressure Liquid; Deoxyguanosine; Hydrogen Peroxide; Hydroxyl Radical; Melatonin; Oxidative Stress; Oxidopamine | 2015 |