Compounds > hydroxyl radical
Page last updated: 2024-09-04

hydroxyl radical and mitoxantrone

hydroxyl radical has been researched along with mitoxantrone in 6 studies

Compound Research Comparison

Studies
(hydroxyl radical)		Trials
(hydroxyl radical)		Recent Studies (post-2010)
(hydroxyl radical)		Studies
(mitoxantrone)		Trials
(mitoxantrone)		Recent Studies (post-2010) (mitoxantrone)
10,147263,6574,5551,0421,004

Protein Interaction Comparison

ProteinTaxonomyhydroxyl radical (IC50)mitoxantrone (IC50)
Chain A, Probable serine/threonine-protein kinase pknBMycobacterium tuberculosis H37Rv0.8
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))2.049
rac GTPase-activating protein 1 isoform aHomo sapiens (human)14.46
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)3.5619
Epidermal growth factor receptorHomo sapiens (human)5.3859
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.0352
Tyrosine-protein kinase FynHomo sapiens (human)1.2579
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)4.9898
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.219
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.6441
ATP-dependent translocase ABCB1Homo sapiens (human)1.501
Proto-oncogene tyrosine-protein kinase ROSHomo sapiens (human)2.9987
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.7487
DNA topoisomerase 2-alphaHomo sapiens (human)5.3
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)1.7853
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)3.5849
Casein kinase II subunit alpha'Homo sapiens (human)0.66
Sodium-dependent noradrenaline transporter Homo sapiens (human)4.9898
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.5619
Multidrug resistance-associated protein 1 Homo sapiens (human)0.0081
Casein kinase II subunit betaHomo sapiens (human)0.66
Casein kinase II subunit alphaHomo sapiens (human)0.66
Tyrosine-protein kinase BTKHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)3.5849
TAR DNA-binding protein 43Homo sapiens (human)10
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)3.5849
Integrase Human immunodeficiency virus 15.9
Multidrug and toxin extrusion protein 2Homo sapiens (human)0.68
Casein kinase II subunit alpha 3Homo sapiens (human)0.66
Multidrug and toxin extrusion protein 1Homo sapiens (human)0.3733
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)3.39
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.9038

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's3 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisher, GR; Gutierrez, PL; Oldcorne, MA; Patterson, LH1
Kharasch, ED; Novak, RF1
Davies, KJ; Doroshow, JH1
Hasinoff, BB; Malisza, KL1
Bailly, C; Bernier, JL; Routier, S; Waring, MJ1
Aledavood, SA; Bakhshizadeh, M; Esmaily, H; Hadizadeh, F; Mohajeri, SA; Sazgarnia, A; Seifi, M; Varshoei Tabrizi, F1

Other Studies

6 other study(ies) available for hydroxyl radical and mitoxantrone

ArticleYear
NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals.
    Biochemical pharmacology, 1992, Feb-04, Volume: 43, Issue:3

    Topics: Animals; Anthraquinones; Antineoplastic Agents; Daunorubicin; Dose-Response Relationship, Drug; Hydroxides; Hydroxyl Radical; Kinetics; Liver; Mitoxantrone; NAD(P)H Dehydrogenase (Quinone); NADP; Oxidation-Reduction; Rats; Structure-Activity Relationship; Superoxides

1992
Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation.
    The Journal of biological chemistry, 1985, Sep-05, Volume: 260, Issue:19

    Topics: Anthraquinones; Antineoplastic Agents; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Kinetics; Linoleic Acid; Linoleic Acids; Lipid Peroxides; Micelles; Mitoxantrone; Spectrophotometry; Xanthine Oxidase

1985
Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.
    The Journal of biological chemistry, 1986, Mar-05, Volume: 261, Issue:7

    Topics: Animals; Anthraquinones; Antibiotics, Antineoplastic; Cattle; Chemical Phenomena; Chemistry; Daunorubicin; Doxorubicin; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Methane; Mitochondria, Heart; Mitomycin; Mitomycins; Mitoxantrone; NAD; NADP; Naphthacenes; Oxidation-Reduction; Oxygen Consumption; Rotenone; Superoxides

1986
Doxorubicin reduces the iron(III) complexes of the hydrolysis products of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and produces hydroxyl radicals.
    Archives of biochemistry and biophysics, 1995, Feb-01, Volume: 316, Issue:2

    Topics: Aerobiosis; Antibiotics, Antineoplastic; Antioxidants; Chelating Agents; Doxorubicin; Electron Spin Resonance Spectroscopy; Ethylenediamines; Ferric Compounds; Ferrous Compounds; Glycine; Heart; Hydrolysis; Hydroxyl Radical; Mitoxantrone; Models, Chemical; Oxidation-Reduction; Razoxane

1995
DNA recognition by two mitoxantrone analogues: influence of the hydroxyl groups.
    FEBS letters, 1996, Feb-05, Volume: 379, Issue:3

    Topics: Antineoplastic Agents; Base Sequence; DNA; DNA Footprinting; Hydroxyl Radical; Mitoxantrone; Molecular Sequence Data; Structure-Activity Relationship

1996
Utilizing photosensitizing and radiosensitizing properties of TiO
    Photodiagnosis and photodynamic therapy, 2019, Volume: 25

    Topics: Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dose-Response Relationship, Drug; Fibrosarcoma; Humans; Hydroxyl Radical; Melanoma; Mitoxantrone; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Radiation-Sensitizing Agents; Titanium

2019