Page last updated: 2024-09-04

hydroxyl radical and mexiletine

hydroxyl radical has been researched along with mexiletine in 2 studies

Compound Research Comparison

Studies (hydroxyl radical)	Trials (hydroxyl radical)	Recent Studies (post-2010) (hydroxyl radical)	Studies (mexiletine)	Trials (mexiletine)	Recent Studies (post-2010) (mexiletine)
10,147	26	3,657	1,488	210	227

Protein Interaction Comparison

Protein	Taxonomy	mexiletine (IC50)
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	1.138
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	10
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	3
Sodium channel protein type 2 subunit alpha	Homo sapiens (human)	2.9

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hideg, K; Kalai, T; Kuppusamy, P; Li, H; Xu, KY; Zhou, L; Zweier, JL	1
Deres, P; Halmosi, R; Hideg, K; Kalai, T; Kovacs, K; Sumegi, B; Toth, A; Toth, K	1

Other Studies

2 other study(ies) available for hydroxyl radical and mexiletine

Article	Year
A pyrroline derivative of mexiletine offers marked protection against ischemia/reperfusion-induced myocardial contractile dysfunction. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Binding, Competitive; Coronary Circulation; Dose-Response Relationship, Drug; Female; Hydroxyl Radical; Mexiletine; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Ouabain; Oxidation-Reduction; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Ventricular Dysfunction, Left; Ventricular Pressure	2000
Akt activation induced by an antioxidant compound during ischemia-reperfusion. Free radical biology & medicine, 2003, Nov-01, Volume: 35, Issue:9 Topics: Androstadienes; Animals; Antioxidants; Caspase 3; Caspases; Energy Metabolism; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hydroxyl Radical; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mexiletine; Molecular Structure; Myocardial Contraction; Phosphatidylinositol 3-Kinases; Phosphocreatine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Wistar; Reperfusion Injury; Superoxides; Wortmannin	2003

Article

Year

A pyrroline derivative of mexiletine offers marked protection against ischemia/reperfusion-induced myocardial contractile dysfunction.

The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Binding, Competitive; Coronary Circulation; Dose-Response Relationship, Drug; Female; Hydroxyl Radical; Mexiletine; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Ouabain; Oxidation-Reduction; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Ventricular Dysfunction, Left; Ventricular Pressure

2000

Akt activation induced by an antioxidant compound during ischemia-reperfusion.

Free radical biology & medicine, 2003, Nov-01, Volume: 35, Issue:9

Topics: Androstadienes; Animals; Antioxidants; Caspase 3; Caspases; Energy Metabolism; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hydroxyl Radical; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mexiletine; Molecular Structure; Myocardial Contraction; Phosphatidylinositol 3-Kinases; Phosphocreatine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Wistar; Reperfusion Injury; Superoxides; Wortmannin

2003