hydroxyl radical has been researched along with levodopa in 27 studies
| Studies (hydroxyl radical) | Trials (hydroxyl radical) | Recent Studies (post-2010) (hydroxyl radical) | Studies (levodopa) | Trials (levodopa) | Recent Studies (post-2010) (levodopa) |
|---|---|---|---|---|---|
| 10,147 | 26 | 3,657 | 17,774 | 1,900 | 4,946 |
| Protein | Taxonomy | hydroxyl radical (IC50) | levodopa (IC50) |
|---|---|---|---|
| integrase, partial | Human immunodeficiency virus 1 | 0.5939 | |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | 0.5939 | |
| Epidermal growth factor receptor | Homo sapiens (human) | 2.88 | |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | 3.729 | |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | 2.146 | |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 2.258 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 11 (40.74) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cohen, G | 2 |
| Hadi, SM; Husain, S | 1 |
| Asanuma, M; Kawai, M; Kohno, M; Masumizu, T; Mori, A; Ogawa, N; Tanaka, K | 1 |
| Bennett, JP; Parker, WD; Smith, TS | 1 |
| Asanuma, M; Edamatsu, R; Kohno, M; Mizukawa, K; Mori, A; Ogawa, N | 1 |
| Butler, J; Land, EJ; Prütz, WA | 1 |
| Cohen, G; Dembiec-Cohen, D; Yakushin, S | 1 |
| Farhan Asad, S; Hadi, SM; Singh, S | 1 |
| Blandini, F; Desideri, S; Godi, L; Mancini, F; Martignoni, E; Nappi, G; Pacchetti, C | 1 |
| Blandini, F; di Jeso, F; Martignoni, E; Nappi, G; Ricotti, R | 1 |
| Chuda, M; Hayabara, T; Ihara, Y; Kuroda, S | 1 |
| Camp, DM; LeWitt, PA; Loeffler, DA | 1 |
| Hashiguchi, H; Ishida, Y; Ishizuka, Y; Mitsuyama, Y; Todaka, K | 1 |
| Ahmad, A; Asad, SF; Hadi, SM; Singh, S | 1 |
| Franceschi, C; Galeazzi, L; Giunta, S; Ronchi, P; Valli, B | 1 |
| Gerlach, M; Kuhn, W; Lehnfeld, R; Riederer, P; Sontag, KH; Waldmeier, P; Xiao, AY | 1 |
| Brus, R; Kostrzewa, JP; Kostrzewa, RA; Kostrzewa, RM; Nowak, P | 1 |
| Abe, Y; Endo, T; Gonda, R; Kaneya, D; Katoh, H; Li, L; Ogata, M; Seki, S; Seki, Y; Shin-Ya, K; Urano, S | 1 |
| Dziubina, A; Gołembiowska, K; Kamińska, K; Kowalska, M | 1 |
| Barman, PK; Borah, A; Mohanakumar, KP; Pandey, M; Usha, R; Varghese, M | 1 |
| Kostrzewa, RA; Kostrzewa, RM; Nowak, P; Skaba, D | 1 |
| Choi, NY; Kim, HT; Kim, MJ; Kim, YS; Koh, SH; Lee, KY; Lee, SJ; Lee, YJ; Park, HH; Park, KH; Yu, HJ | 1 |
| Dziubina, A; Gołembiowska, K | 2 |
| Zhang, H; Zhou, Q | 1 |
| Alharrasi, A; Ashraf, GM; Damanhouri, GA; Hadi, SM; Khan, HY; Perveen, A; Tabrez, S | 1 |
2 review(s) available for hydroxyl radical and levodopa
| Article | Year |
|---|---|
Enzymatic/nonenzymatic sources of oxyradicals and regulation of antioxidant defenses.
Topics: Animals; Antioxidants; Ascorbic Acid; Enzymes; Escherichia coli; Free Radicals; Glutathione; Humans; Hydrogen Peroxide; Hydroxyl Radical; Levodopa; Mesencephalon; Neurons; Paraquat; Peroxides; Reactive Oxygen Species; Superoxides | 1994 |
Peculiarities of L: -DOPA treatment of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Basal Ganglia; Biological Transport; Brain Chemistry; Dopamine; Dyskinesias; Humans; Hydroxyl Radical; Levodopa; Parkinson Disease; Rats; Receptors, Dopamine | 2005 |
2 trial(s) available for hydroxyl radical and levodopa
| Article | Year |
|---|---|
Peripheral markers of oxidative stress in Parkinson's disease. The role of L-DOPA.
Topics: Antiparkinson Agents; Biomarkers; Blood Platelets; Dopamine; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Levodopa; Linear Models; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Sodium Salicylate; Superoxide Dismutase; Tyrosine | 1999 |
Determination of hydroxyl free radical formation in human platelets using high-performance liquid chromatography with electrochemical detection.
Topics: Adult; Antiparkinson Agents; Blood Platelets; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Hydroxybenzoates; Hydroxyl Radical; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1999 |
23 other study(ies) available for hydroxyl radical and levodopa
| Article | Year |
|---|---|
The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence.
Topics: Animals; Brain; Catalase; Catecholamines; Dopamine; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Levodopa; Monoamine Oxidase; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Selegiline; Superoxide Dismutase; Superoxides | 1983 |
Strand scission in DNA induced by L-DOPA in the presence of Cu(II).
Topics: Animals; Cattle; Copper; DNA; DNA Damage; Hydrogen Peroxide; Hydroxyl Radical; Levodopa; Plasmids; Reactive Oxygen Species; Single-Strand Specific DNA and RNA Endonucleases; Spectrometry, Fluorescence | 1995 |
Bromocriptine protects mice against 6-hydroxydopamine and scavenges hydroxyl free radicals in vitro.
Topics: Animals; Bromocriptine; Carbidopa; Corpus Striatum; Desipramine; Dopamine; Free Radical Scavengers; Hydroxyl Radical; Injections, Intraventricular; Levodopa; Male; Mice; Mice, Inbred ICR; Oxidopamine | 1994 |
L-dopa increases nigral production of hydroxyl radicals in vivo: potential L-dopa toxicity?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Acid; Hydroxyl Radical; Levodopa; Microdialysis; Mitochondria; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Selegiline; Stereotaxic Techniques; Substantia Nigra | 1994 |
Degeneration of dopaminergic neurons and free radicals. Possible participation of levodopa.
Topics: Animals; Corpus Striatum; Culture Techniques; Dopamine; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxides; Hydroxyl Radical; Levodopa; Male; Mice; Mice, Inbred ICR; Microscopy, Electron; Nerve Degeneration; Receptors, Dopamine; Subcellular Fractions; Substantia Nigra; Superoxides; Thiobarbiturates | 1993 |
Photocatalytic and free radical interactions of the heterocyclic N-oxide resazurin with NADH, GSH, and Dopa.
Topics: Catalysis; Dose-Response Relationship, Radiation; Free Radicals; Gamma Rays; Glutathione; Hydroxyl Radical; Indicators and Reagents; Kinetics; Levodopa; NAD; Oxazines; Oxidation-Reduction; Photochemistry; Spectrophotometry; Time Factors; Xanthenes | 1996 |
Protein L-dopa as an index of hydroxyl radical attack on protein tyrosine.
Topics: Animals; Chromatography, High Pressure Liquid; Hydroxyl Radical; Hydroxylation; Levodopa; Rats; Tyrosine | 1998 |
Uric acid inhibits L-DOPA-CU(II) mediated DNA cleavage.
Topics: Animals; Cattle; Chromosome Breakage; Copper; DNA; DNA Damage; DNA, Superhelical; Dose-Response Relationship, Drug; Hydroxyl Radical; Levodopa; Mannitol; Oxidation-Reduction; Plasmids; Thiourea; Uric Acid; Xanthine | 1998 |
Hydroxyl radical and superoxide dismutase in blood of patients with Parkinson's disease: relationship to clinical data.
Topics: Age Factors; Age of Onset; Aged; Antiparkinson Agents; Bromocriptine; Disease Progression; Erythrocytes; Humans; Hydroxyl Radical; Levodopa; Middle Aged; Multiple System Atrophy; Parkinson Disease; Pergolide; Severity of Illness Index; Statistics as Topic; Superoxide Dismutase; Time Factors | 1999 |
L-DOPA does not enhance hydroxyl radical formation in the nigrostriatal dopamine system of rats with a unilateral 6-hydroxydopamine lesion.
Topics: Animals; Cerebellum; Corpus Striatum; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Injections; Levodopa; Male; Mesencephalon; Methamphetamine; Microdialysis; Osmolar Concentration; Oxidopamine; Rats; Rats, Sprague-Dawley; Salicylates; Substantia Nigra | 2000 |
Repeated administration of high dose levodopa enhances hydroxyl radical production in the rat striatum denervated with 6-hydroxydopamine.
Topics: Animals; Corpus Striatum; Denervation; Drug Administration Schedule; Female; Hydroxyl Radical; Injections, Intraperitoneal; Levodopa; Oxidopamine; Rats; Rats, Wistar | 2000 |
Inhibition of L-DOPA-Cu(II)-mediated DNA cleavage by bilirubin.
Topics: Animals; Bilirubin; Cattle; Copper; DNA; DNA Damage; DNA, Superhelical; Drug Interactions; Hydroxyl Radical; Levodopa; Plasmids | 2000 |
Transformation of beta-amyloid (A beta) (1-42) tyrosine to L-dopa as the result of in vitro hydroxyl radical attack.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Chromatography, High Pressure Liquid; Humans; Hydroxyl Radical; Hydroxylation; Inflammation; Levodopa; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Tyrosine | 2000 |
The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Levodopa; Male; Microdialysis; Nitriles; Nitrophenols; Oxidative Stress; Parkinsonian Disorders; Rats; Rats, Wistar; Tolcapone | 2001 |
Trapping effect of eugenol on hydroxyl radicals induced by L-DOPA in vitro.
Topics: Aniline Compounds; Antiparkinson Agents; Chelating Agents; Electron Spin Resonance Spectroscopy; Eugenol; Hydroxyl Radical; Iron Chelating Agents; Levodopa; Oxidants; Pyrogallol | 2005 |
Effect of adenosine A(2A) receptor antagonists on L-DOPA-induced hydroxyl radical formation in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Area Under Curve; Benserazide; Catalepsy; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Rats; Rats, Wistar; Time Factors; Triazines; Triazoles; Xanthines | 2009 |
Striatal dopamine level contributes to hydroxyl radical generation and subsequent neurodegeneration in the striatum in 3-nitropropionic acid-induced Huntington's disease in rats.
Topics: Animals; Convulsants; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Huntington Disease; Hydroxyl Radical; Lameness, Animal; Levodopa; Male; Mitochondria; Nerve Degeneration; Neurotoxins; Nitro Compounds; Oxidative Phosphorylation; Oxidative Stress; Propionates; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2009 |
Acute L: -DOPA effect on hydroxyl radical- and DOPAC-levels in striatal microdialysates of parkinsonian rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Female; Hydroxyindoleacetic Acid; Hydroxyl Radical; Injections, Intraventricular; Levodopa; Male; Microdialysis; Oxidopamine; Parkinsonian Disorders; Pregnancy; Rats; Sympatholytics; Time Factors | 2010 |
L-DOPA neurotoxicity is prevented by neuroprotective effects of erythropoietin.
Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Erythropoietin; Humans; Hydroxyl Radical; Levodopa; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rats; Recombinant Proteins; Signal Transduction; Time Factors | 2011 |
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles | 2012 |
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Triazines; Triazoles; Vesicular Monoamine Transport Proteins | 2012 |
Tyrosinase inhibitory effects and antioxidative activities of saponins from Xanthoceras Sorbifolia nutshell.
Topics: Absorption; Antineoplastic Agents, Phytogenic; Antioxidants; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydroxyl Radical; Industrial Waste; Kinetics; Levodopa; Monophenol Monooxygenase; Nuts; Oils; Oxidative Stress; Oxygen; Reactive Oxygen Species; Sapindaceae; Saponins; Superoxides; Time Factors; Triterpenes | 2013 |
Pro-oxidant DNA breakage induced by the interaction of L-DOPA with Cu(II): a putative mechanism of neurotoxicity.
Topics: Antiparkinson Agents; Chelating Agents; Comet Assay; Copper; DNA Breaks; Humans; Hydroxyl Radical; Levodopa; Lymphocytes; Neurotoxicity Syndromes; Oxidation-Reduction; Phenanthrolines; Reactive Oxygen Species; Superoxides | 2015 |