hydroxyl radical has been researched along with isoniazid in 12 studies
| Studies (hydroxyl radical) | Trials (hydroxyl radical) | Recent Studies (post-2010) (hydroxyl radical) | Studies (isoniazid) | Trials (isoniazid) | Recent Studies (post-2010) (isoniazid) |
|---|---|---|---|---|---|
| 10,147 | 26 | 3,657 | 21,815 | 960 | 4,493 |
| Protein | Taxonomy | hydroxyl radical (IC50) | isoniazid (IC50) |
|---|---|---|---|
| Myeloperoxidase | Homo sapiens (human) | 4.85 | |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | 8.29 | |
| Putative FAD-containing monooxygenase MymA | Mycobacterium tuberculosis H37Rv | 4.9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ito, K; Kawanishi, S; Yamamoto, K | 1 |
| Van der Walt, BJ; Van Zyl, JM | 1 |
| Hermes-Lima, M; Nagy, E; Ponka, P; Schulman, HM | 1 |
| Andrews, M; Hermes-Lima, M; Ponka, P; Santos, NC; Schulman, HM; Yan, J | 1 |
| Hermes-Lima, M; Ponka, P; Schulman, HM | 1 |
| Andrade, RG; Gonçalves, MS; Hermes-Lima, M | 1 |
| Alonso, A; Gomes, CS; Hermes-Lima, M; Lopes, GK; MaurÃcio, AQ; Oliveira, RG | 1 |
| Arshad, N; Khan, M; Mirza, B; Rashid, N; Razzque, S; Saleem, S; Yunus, U | 1 |
| Kiddle, JJ; Mezyk, SP; Rickman, KA; Swancutt, KL | 1 |
| Ajitkumar, P; Nair, RR; Sebastian, J; Sharan, D; Swaminath, S | 1 |
| Ajitkumar, P; Nair, RR; Paul, A; Pradhan, A; Sebastian, J; Swaminath, S | 1 |
| Cheng, Y; Lu, X; Wang, C; Zhu, W | 1 |
12 other study(ies) available for hydroxyl radical and isoniazid
| Article | Year |
|---|---|
Manganese-mediated oxidative damage of cellular and isolated DNA by isoniazid and related hydrazines: non-Fenton-type hydroxyl radical formation.
Topics: Autoradiography; Cells, Cultured; DNA; DNA Damage; Electron Spin Resonance Spectroscopy; Electrophoresis, Gel, Pulsed-Field; Free Radical Scavengers; Hydrazines; Hydroxides; Hydroxyl Radical; Isoniazid; Manganese; Oxygen | 1992 |
Apparent hydroxyl radical generation without transition metal catalysis and tyrosine nitration during oxidation of the anti-tubercular drug, isonicotinic acid hydrazide.
Topics: Catalase; Hydroxyl Radical; Isoniazid; Kinetics; Metals; Nitrates; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Thiobarbituric Acid Reactive Substances; Tyrosine | 1994 |
The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against *OH-mediated strand breaks.
Topics: Antioxidants; DNA Damage; Ferrous Compounds; Hydroxyl Radical; Hypoxanthine; Iron Chelating Agents; Isoniazid; Oxidation-Reduction; Plasmids; Pyridoxal; Xanthine Oxidase | 1998 |
EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on *OH formation by the Fenton reaction.
Topics: Cyclic N-Oxides; Deoxyribose; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide; Hydroxyl Radical; Iron; Isoniazid; Oxidation-Reduction; Pyridoxal; Spin Trapping | 1999 |
The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate.
Topics: Ascorbic Acid; Chelating Agents; Deoxyribose; Dimethyl Sulfoxide; DNA Damage; Edetic Acid; Ferric Compounds; Free Radical Scavengers; Hydroxyl Radical; Isoniazid; Kinetics; Models, Chemical; Plasmids; Pyridoxal; Structure-Activity Relationship | 2000 |
Pyridoxal isonicotinoyl hydrazone (PIH) prevents copper-mediated in vitro free radical formation.
Topics: Ascorbic Acid; Copper Sulfate; Deoxyribose; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; In Vitro Techniques; Iron Chelating Agents; Isoniazid; Kinetics; Oxidation-Reduction; Oxygen; Pyridoxal | 2001 |
Pyridoxal isonicotinoyl hydrazone inhibits iron-induced ascorbate oxidation and ascorbyl radical formation.
Topics: Ascorbic Acid; Chelating Agents; Deoxyribose; Edetic Acid; Electron Spin Resonance Spectroscopy; Ferric Compounds; Free Radicals; Hydroxyl Radical; Isoniazid; Nitrilotriacetic Acid; Oxidation-Reduction; Oxidative Stress; Pyridoxal | 2003 |
Electrochemical and spectroscopic investigations of isoniazide and its analogs with ds.DNA at physiological pH: evaluation of biological activities.
Topics: Animals; Anti-Bacterial Agents; Binding Sites; DNA; DNA Damage; Electrochemistry; Free Radical Scavengers; Hydrazines; Hydrogen-Ion Concentration; Hydroxyl Radical; Isoniazid; Oxidative Stress; Pyrazines; Spectrum Analysis; Temperature | 2012 |
Isoniazid: Radical-induced oxidation and reduction chemistry.
Topics: Hydroxyl Radical; Isoniazid; Molecular Structure; Oxidation-Reduction; Temperature | 2013 |
Heterogeneity of ROS levels in antibiotic-exposed mycobacterial subpopulations confers differential susceptibility.
Topics: Anti-Bacterial Agents; Cyclic N-Oxides; Hydrogen Peroxide; Hydroxyl Radical; Isoniazid; Microbial Viability; Models, Biological; Mycobacterium smegmatis; Oxidative Stress; Phenotype; Reactive Oxygen Species; Rifampin; Spin Labels; Superoxides; Thiourea | 2019 |
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Bacterial; Drug Tolerance; Ethambutol; Genome, Bacterial; Hydroxyl Radical; Isoniazid; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Mycobacterium smegmatis; Mycobacterium tuberculosis; Oxidation-Reduction; Oxidative Stress | 2020 |
Fabrication of a Tubular CuO/NiO Biomimetic Nanozyme with Synergistically Promoted Peroxidase-like Performance for Isoniazid Sensing.
Topics: Anti-Bacterial Agents; Biomimetics; Copper; Hydroxyl Radical; Isoniazid; Oxidoreductases; Peroxidase; Peroxidases | 2022 |