Page last updated: 2024-09-04

hydroxyl radical and indomethacin

hydroxyl radical has been researched along with indomethacin in 25 studies

Compound Research Comparison

Studies
(hydroxyl radical)
Trials
(hydroxyl radical)
Recent Studies (post-2010)
(hydroxyl radical)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
10,147263,65729,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyhydroxyl radical (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19905 (20.00)18.7374
1990's10 (40.00)18.2507
2000's7 (28.00)29.6817
2010's3 (12.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barreto, JC; Miller, TA; Schmidt, KL; Smith, GS; Tornwall, MS1
Arakawa, T; Kobayashi, K; Sakuma, H1
Bast, A; Rademaker, B; Tuinstra, TJ; Van der Vliet, A1
Aruoma, OI; Halliwell, B1
Caplan, M; Hess, ML; Lucchesi, B; Romson, JL; Rowe, GT1
Fox, IH; Heldsinger, AA; Vinik, AI1
Ramwell, P; Thomas, G1
DeMocko, C; Sagone, AL; Wells, RM1
Laxdal, VA; Prasad, K1
Aldini, G; Carini, M; Macciocchi, A; Maffei Facino, R; Saibene, L1
Dai, FX; Diederich, A; Diederich, D; Jameson, M; Lüscher, T; Skopec, J1
Gupta, JB; Prasad, K2
Bharadwaj, LA; Prasad, K1
Colavita, AR; FitzGerald, GA; Ghiselli, A; Iuliano, L; Leo, R; Pignatelli, P; Praticò, D; Pulcinelli, FM; Violi, F1
Langenstroer, P; Pieper, GM; Siebeneich, W1
Bandyopadhyay, D; Bandyopadhyay, U; Banerjee, RK; Biswas, K; Reiter, RJ1
Grossmann, V; Stetinová, V1
Ambrosio, G; Berlowitz, CO; Bettini, M; Biondi, R; Kass, DA; L'Abbate, A; Lee, CI; Paolocci, N; Rossi, R; Xia, Y; Zweier, JL1
Amer, MA; El-Missiry, MA; Othman, AI1
Angeles', FM; Bobrowski, P; Condezo, LA; Lao, J; Miller, MJ; Musah, RA; Okuhama, NN; Sandoval, M; Zhang, XJ1
Campbell, WB; Chawengsub, Y; Cui, L; Falck, JR; Isbell, MA; Nithipatikom, K1
Jiménez, S; Mas, R; Molina, V; Oyárzabal, A; Pérez, Y1
Adetunde, TO; Orisaremi, CO; Sansaliyu, I; Sofidiya, MO1
Dong, K; Sun, JY; Xing, JF; You, CY; You, HS1

Other Studies

25 other study(ies) available for hydroxyl radical and indomethacin

ArticleYear
Protective effect of dimethylthiourea against mucosal injury in rat stomach. Implications for hydroxyl radical mechanism.
    Digestive diseases and sciences, 1992, Volume: 37, Issue:9

    Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Female; Free Radicals; Gastric Mucosa; Hydroxides; Hydroxyl Radical; Indomethacin; Rats; Rats, Inbred Strains; Thiourea

1992
Effects of active oxygen species on damage to and prostaglandin synthesis in cultured rat gastric cells.
    Osaka city medical journal, 1992, Volume: 38, Issue:1

    Topics: Animals; Catalase; Cells, Cultured; Gastric Mucosa; Hydroxides; Hydroxyl Radical; Indomethacin; Male; Oxygen; Prostaglandins; Rats; Rats, Inbred Strains; Xanthine; Xanthine Oxidase; Xanthines

1992
Intestinal motility disorder induced by peroxides: possible role of lipid peroxidation.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 70, Issue:2

    Topics: Animals; Benzene Derivatives; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guanylate Cyclase; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Indomethacin; Lipid Peroxidation; Male; Masoprocol; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1990
Inactivation of alpha 1-antiproteinase by hydroxyl radicals. The effect of uric acid.
    FEBS letters, 1989, Feb-13, Volume: 244, Issue:1

    Topics: alpha 1-Antitrypsin; Ascorbic Acid; Blood Proteins; Chemical Phenomena; Chemistry; Edetic Acid; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxides; Hydroxyl Radical; Hypoxanthine; Hypoxanthines; Indomethacin; Iron; Nitrous Oxide; Pancreatic Elastase; Piroxicam; Protease Inhibitors; Pulse Radiolysis; Superoxides; Uric Acid; Xanthine Oxidase

1989
Identification of hydrogen peroxide and hydroxyl radicals as mediators of leukocyte-induced myocardial dysfunction. Limitation of infarct size with neutrophil inhibition and depletion.
    Advances in myocardiology, 1985, Volume: 5

    Topics: Adenosine Triphosphatases; Animals; Butylated Hydroxytoluene; Calcium; Catalase; Dogs; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Ibuprofen; Indomethacin; Leukocytes; Male; Mannitol; Myocardial Infarction; Myocardium; Neutrophils; Sarcoplasmic Reticulum; Superoxide Dismutase; Tetradecanoylphorbol Acetate

1985
Inhibition of guinea-pig oxyntic cell function by adenosine and prostaglandins.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Bucladesine; Carbachol; Dose-Response Relationship, Drug; Female; Gastrins; Guinea Pigs; Histamine; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Indomethacin; Parietal Cells, Gastric; Phenylisopropyladenosine; Prostaglandins; Receptors, Cell Surface; Receptors, Purinergic

1986
Induction of vascular relaxation by hydroperoxides.
    Biochemical and biophysical research communications, 1986, Aug-29, Volume: 139, Issue:1

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Chlorobenzoates; Endothelium; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Indomethacin; Leukotrienes; Lipid Peroxides; Male; Muscle Contraction; Muscle Relaxation; Peroxides; Rats; Rats, Inbred Strains; Superoxides; Vasodilation

1986
Evidence that OH. production by human PMNs is related to prostaglandin metabolism.
    Inflammation, 1980, Volume: 4, Issue:1

    Topics: Aspirin; Granulocytes; Humans; Hydrogen; Hydroxides; Hydroxyl Radical; Indomethacin; Neutrophils; Oxygen; Phagocytosis; Phenols; Prostaglandins; Zymosan

1980
Hydroxyl radical-scavenging property of indomethacin.
    Molecular and cellular biochemistry, 1994, Jul-27, Volume: 136, Issue:2

    Topics: Chromatography, High Pressure Liquid; Free Radical Scavengers; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Indomethacin; Photolysis; Sensitivity and Specificity; Ultraviolet Rays

1994
Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model.
    International journal of tissue reactions, 1993, Volume: 15, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Diclofenac; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Indomethacin; Liposomes; Membranes, Artificial; Models, Biological; Phosphatidylcholines; Sulfonamides

1993
Endothelium-derived contracting factors in resistance arteries of young spontaneously hypertensive rats before development of overt hypertension.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 21, Issue:3

    Topics: Age Factors; Animals; Arginine; Endothelins; Endothelium, Vascular; Hydroxides; Hydroxyl Radical; Hypertension; In Vitro Techniques; Indomethacin; Male; Nitroarginine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasoconstriction; Vasodilation

1993
Influence of hydroxyl radical on rabbit airway smooth muscle chronically exposed to H2O2 in vivo.
    The American journal of physiology, 1993, Volume: 264, Issue:6 Pt 1

    Topics: Acetylcholine; Animals; Catalase; Epithelium; Free Radicals; Glucose Oxidase; Histological Techniques; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Indomethacin; Muscle Contraction; Muscle, Smooth; Rabbits; Time Factors; Trachea

1993
Mechanism of hydroxyl radical-induced modulation of vascular tone.
    Free radical biology & medicine, 1997, Volume: 22, Issue:3

    Topics: Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hydroxyl Radical; Indomethacin; Mannitol; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Rabbits

1997
Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated.
    Circulation, 1997, Feb-18, Volume: 95, Issue:4

    Topics: Acridines; Aerobiosis; Aspirin; Benzoates; Blood Platelets; Catalase; Cell Hypoxia; Deoxyribose; Free Radical Scavengers; Humans; Hydroxyl Radical; In Vitro Techniques; Indomethacin; L-Lactate Dehydrogenase; Mannitol; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Superoxide Dismutase; Superoxides

1997
Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals.
    Cardiovascular research, 1997, Volume: 34, Issue:1

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Catalase; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diuretics, Osmotic; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxyl Radical; In Vitro Techniques; Indomethacin; Male; Mannitol; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; Norepinephrine; Phenylacetates; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Sulfonamides; Superoxide Dismutase; Vasoconstrictor Agents; Vasodilator Agents

1997
Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical.
    Journal of pineal research, 2000, Volume: 29, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cold Temperature; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydroxyl Radical; Indomethacin; Lipid Peroxidation; Melatonin; Omeprazole; Peptic Ulcer; Ranitidine; Rats; Rats, Wistar; Stress, Physiological

2000
Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm).
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:5

    Topics: Alloxan; Animals; Antioxidants; Bronchial Spasm; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Gastric Mucosa; Guinea Pigs; Hydroxyl Radical; Indomethacin; Male; Mice; Rats; Rats, Wistar

2000
Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart.
    Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:4

    Topics: Acetylcholine; Animals; Bradykinin; Cyclooxygenase Inhibitors; Electrolysis; Heart; Hydroxyl Radical; In Vitro Techniques; Indomethacin; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Superoxides

2001
The protective action of melatonin on indomethacin-induced gastric and testicular oxidative stress in rats.
    Redox report : communications in free radical research, 2001, Volume: 6, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytosol; Gastric Mucosa; Hydroxyl Radical; Indomethacin; Isoenzymes; L-Lactate Dehydrogenase; Lipid Peroxidation; Lipoxygenase; Male; Melatonin; Mitochondria; Oxidation-Reduction; Oxidative Stress; Rats; Superoxide Dismutase; Testis; Thiobarbituric Acid Reactive Substances

2001
Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:4

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Cat's Claw; Cells, Cultured; Chromatography, High Pressure Liquid; DNA Primers; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Gastritis; Humans; Hydroxyl Radical; In Situ Nick-End Labeling; Indomethacin; Inhibitory Concentration 50; Lipid Peroxidation; Lipopolysaccharides; Male; Mice; Phytotherapy; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

2002
Relaxant effect of oxygen free radicals on rabbit tracheal smooth muscle.
    Pulmonary pharmacology & therapeutics, 2002, Volume: 15, Issue:4

    Topics: Analysis of Variance; Animals; Asthma; Cyclooxygenase Inhibitors; Epithelium; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Indomethacin; Muscle Relaxation; Muscle, Smooth; Oxidants; Rabbits; Superoxides; Trachea

2002
Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR.
    Journal of the American Society for Mass Spectrometry, 2008, Volume: 19, Issue:4

    Topics: Animals; Animals, Newborn; Aorta; Calcimycin; Cyclotrons; Hydroxyeicosatetraenoic Acids; Hydroxyl Radical; Indomethacin; Rabbits; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry

2008
Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action.
    Journal of natural medicines, 2013, Volume: 67, Issue:1

    Topics: Alcohols; Animals; Glutathione Peroxidase; Hydroxyl Radical; Indomethacin; Lipid Peroxidation; Malondialdehyde; Rats; Rats, Wistar; Stomach Ulcer; Superoxide Dismutase; Waxes

2013
Gastroprotective and antioxidant potentials of ethanolic stem bark extract of Margaritaria discoidea (Euphorbiaceae) in rats.
    Journal of ethnopharmacology, 2015, Aug-02, Volume: 171

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biphenyl Compounds; Ethanol; Euphorbiaceae; Gastric Mucosa; Hydroxyl Radical; Indomethacin; Male; Mice; Phytotherapy; Picrates; Plant Bark; Plant Extracts; Plant Stems; Pylorus; Rats, Wistar; Ulcer

2015
Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid.
    Pharmaceutical biology, 2016, Volume: 54, Issue:10

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cotton Fiber; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Female; Granuloma, Foreign-Body; Hot Temperature; Hydroxyl Radical; Indomethacin; Male; Malondialdehyde; Mice, Inbred ICR; Pain; Rats, Sprague-Dawley; Shikimic Acid; Superoxides; Time Factors; Xylenes

2016