Compounds > hydroxyl radical
Page last updated: 2024-09-04

hydroxyl radical and baicalein

hydroxyl radical has been researched along with baicalein in 8 studies

Compound Research Comparison

Studies
(hydroxyl radical)		Trials
(hydroxyl radical)		Recent Studies (post-2010)
(hydroxyl radical)		Studies
(baicalein)		Trials
(baicalein)		Recent Studies (post-2010) (baicalein)
10,147263,6571,3229839

Protein Interaction Comparison

ProteinTaxonomyhydroxyl radical (IC50)baicalein (IC50)
Chain A, RNA-directed RNA polymerase NS5Dengue virus 2 16681-PDK5335.06
Lysine-specific demethylase 4EHomo sapiens (human)3
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)2.075
Cyclin-dependent kinase 1Homo sapiens (human)6.53
Trypsin-1Homo sapiens (human)3.7
Trypsin-2Homo sapiens (human)3.7
Tyrosine-protein kinase YesHomo sapiens (human)3.3
Cytochrome P450 3A4Homo sapiens (human)9.2
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)0.85
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus0.94
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 21.22
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)10
G2/mitotic-specific cyclin-B1Homo sapiens (human)6.53
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)6.2
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)2.08
Casein kinase II subunit alpha'Homo sapiens (human)10
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)5.7
Trypsin-3Homo sapiens (human)3.7
Testosterone 17-beta-dehydrogenase 3Homo sapiens (human)9.3
Alpha-synucleinHomo sapiens (human)8.2
G protein-coupled receptor kinase 6Homo sapiens (human)8.7
1-deoxy-D-xylulose 5-phosphate reductoisomeraseEscherichia coli K-122.2
Xanthine dehydrogenase/oxidaseHomo sapiens (human)2.79
Serine/threonine-protein kinase PLK1Homo sapiens (human)9
Casein kinase II subunit betaHomo sapiens (human)10
Casein kinase II subunit alphaHomo sapiens (human)10
Xanthine dehydrogenase/oxidaseBos taurus (cattle)3.3
Integrase Human immunodeficiency virus 13.296
Polyunsaturated fatty acid lipoxygenase ALOX15BRattus norvegicus (Norway rat)0.26
Casein kinase II subunit alpha 3Homo sapiens (human)10
Aurora kinase BHomo sapiens (human)4.06

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Edamatsu, R; Hamada, H; Hiramatsu, M; Mori, A1
Gao, Z; Huang, K; Xu, H; Yang, X1
Chen, TF; Chou, DS; Hsiao, G; Hsieh, CY; Lee, JJ; Sheu, JR; Tsai, YJ1
Chou, DS; Hsiao, G; Lai, YA; Sheu, JR; Tsai, YJ1
Dimitrić Marković, JM; Filipović, N; Marković, ZS; Milenković, D1
Hyun, JW; Kang, KA; Kang, SS; Kim, BJ; Lee, IK; Zhang, R1
Chen, C; Chen, D; Li, X; Tian, Y; Wang, X; Xie, H; Xie, Y1
Alomar, SY; Alwasel, SH; Chrienova, Z; Cizmar, E; Cvik, M; Jomova, K; Kuca, K; Lauro, P; Nepovimova, E; Oleksak, P; Rhodes, CJ; Valko, M1

Other Studies

8 other study(ies) available for hydroxyl radical and baicalein

ArticleYear
Free radical scavenging action of baicalein.
    Archives of biochemistry and biophysics, 1993, Volume: 306, Issue:1

    Topics: Animals; Brain; Cerebral Cortex; Chlorides; Drugs, Chinese Herbal; Electron Spin Resonance Spectroscopy; Epilepsy; Ferric Compounds; Flavanones; Flavonoids; Free Radical Scavengers; Hippocampus; Hydroxyl Radical; Male; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Thiobarbituric Acid Reactive Substances

1993
Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi.
    Biochimica et biophysica acta, 1999, Nov-16, Volume: 1472, Issue:3

    Topics: Animals; Antioxidants; Binding Sites; Brain; China; Drugs, Chinese Herbal; Electron Spin Resonance Spectroscopy; Flavanones; Flavonoids; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydroxyl Radical; Lipid Peroxidation; Mitochondria; NADP; Plants, Medicinal; Rats; Tumor Cells, Cultured

1999
Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study.
    Journal of agricultural and food chemistry, 2007, Feb-07, Volume: 55, Issue:3

    Topics: Arachidonate 12-Lipoxygenase; Arachidonic Acid; Blood Platelets; Electron Spin Resonance Spectroscopy; Fatty Acids; Flavanones; Glutathione; Humans; Hydroxyl Radical; Lipoxygenase Inhibitors; Oxidants

2007
Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase.
    Free radical biology & medicine, 2009, Apr-15, Volume: 46, Issue:8

    Topics: Animals; Arachidonate 12-Lipoxygenase; Cell Proliferation; Electron Spin Resonance Spectroscopy; Flavanones; Growth Inhibitors; Hydroxyl Radical; Melanoma, Experimental; Mice; Reactive Oxygen Species; RNA, Small Interfering; Superoxides

2009
Mechanistic study of the structure-activity relationship for the free radical scavenging activity of baicalein.
    Journal of molecular modeling, 2011, Volume: 17, Issue:10

    Topics: Flavanones; Free Radical Scavengers; Hydroxyl Radical; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Structure-Activity Relationship

2011
Mitochondria protection of baicalein against oxidative damage via induction of manganese superoxide dismutase.
    Environmental toxicology and pharmacology, 2011, Volume: 31, Issue:1

    Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Fractionation; Cell Survival; Cell-Free System; Coloring Agents; Cricetinae; DNA Fragmentation; Electrophoretic Mobility Shift Assay; Flavanones; Hydroxyl Radical; Indicators and Reagents; Mitochondria; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Tetrazolium Salts; Thiazoles

2011
Protective Mechanism of the Antioxidant Baicalein toward Hydroxyl Radical-Treated Bone Marrow-Derived Mesenchymal Stem Cells.
    Molecules (Basel, Switzerland), 2018, Jan-20, Volume: 23, Issue:1

    Topics: Animals; Antioxidants; Bone Marrow Cells; Cations, Divalent; Cell Survival; Copper; Cytoprotection; Flavanones; Free Radical Scavengers; Hydroxyl Radical; Iron Chelating Agents; Mesenchymal Stem Cells; Oxidative Stress; Rats; Rats, Sprague-Dawley

2018
The role of redox active copper(II) on antioxidant properties of the flavonoid baicalein: DNA protection under Cu(II)-Fenton reaction and Cu(II)-ascorbate system conditions.
    Journal of inorganic biochemistry, 2023, Volume: 245

    Topics: Antioxidants; Ascorbic Acid; Copper; DNA; DNA Damage; Flavonoids; Hydroxyl Radical; Metals; Oxidation-Reduction; Reactive Oxygen Species

2023