hydroxyl radical has been researched along with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in 32 studies
| Studies (hydroxyl radical) | Trials (hydroxyl radical) | Recent Studies (post-2010) (hydroxyl radical) | Studies (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) | Trials (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) | Recent Studies (post-2010) (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) |
|---|---|---|---|---|---|
| 10,147 | 26 | 3,657 | 3,859 | 8 | 1,052 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.38) | 18.7374 |
| 1990's | 14 (43.75) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiueh, CC; Huang, SJ; Murphy, DL | 1 |
| Chiueh, CC; Obata, T | 1 |
| Felix, CC; Kalyanaraman, B; Korytowski, W | 1 |
| Barbeau, A; Donaldson, J; Poirier, J | 1 |
| Cohen, G | 1 |
| Chiueh, CC; Miyake, H; Peng, MT | 1 |
| Adams, JD; Cadenas, E; Kim, SS; Klaidman, LK; Leung, AC | 1 |
| Jiang, DH; Lan, J | 2 |
| Beal, MF; Dichgans, J; Klockgether, T; Matthews, RT; Schulz, JB | 1 |
| Bennett, JP; Smith, TS | 1 |
| Bennett, JP; Cassarino, DS; Fall, CP; Halvorsen, EM; Miller, SW; Parker, WD; Parks, JP; Smith, TS; Swerdlow, RH | 1 |
| Mohanakumar, KP; Muralikrishnan, D | 1 |
| Aubin, N; Carter, C; Curet, O; Deffois, A | 1 |
| Earl, CD; Ferger, B; Kuschinsky, K; Oertel, WH; Spratt, C; Teismann, P | 1 |
| Ferger, B; Kuschinsky, K; Seitz, G; Spratt, C; Teismann, P | 1 |
| Cheng, FC; Dryhurst, G; Han, J; Yang, Z | 1 |
| Mohanakumar, KP; Muralikrishnan, D; Thomas, B | 2 |
| Albers, DW; Andreassen, OA; Beal, MF; Carlson, EJ; Dedeoglu, A; Epstein, CJ; Ferrante, RJ; Klivenyi, P | 1 |
| Obata, T; Yamanaka, Y | 1 |
| Ferger, B; Schwaninger, M; Teismann, P; Weih, F | 1 |
| Obata, T | 2 |
| Mohanakumar, KP; Muralikrishnan, D; Samantaray, S | 1 |
| Mohanakumar, KP; Thomas, B | 1 |
| Bergh, JJ; Loots, DT; Mienie, LJ; Van der Schyf, CJ | 1 |
| Galoyan, AA; Knaryan, VH; Mohanakumar, KP; Samantaray, S | 1 |
| Galoyan, AA; Knaryan, VH; Mohanakumar, KP; Samantaray, S; Srinivasan, A; Varghese, M | 1 |
| Cologni, P; Costa-Campos, L; Fernandes, MS; Marcos, TD; Milioli, EM; Santos, CC; Schoenfelder, T; Yunes, VM | 1 |
| Appukuttan, TA; Mohanakumar, KP; Navneet, AK; Pandey, M | 1 |
| Pu, XP; Wang, YH; Zhai, SY; Zhang, HN; Zhou, JJ | 1 |
5 review(s) available for hydroxyl radical and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Article | Year |
|---|---|
Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Diseases; Corpus Striatum; Deferoxamine; Dopamine; Female; Glutathione; Glutathione Disulfide; Hydroxyl Radical; Iron; Lipid Peroxides; Male; Mice; Nerve Degeneration; Osmolar Concentration; Vitamin E | 1997 |
The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine Agents; Hydroxyl Radical; Mice; Mitochondria; Neurodegenerative Diseases; Nitric Oxide; Nitro Compounds; Primates; Propionates; Rats | 1997 |
[Parkinsonism induced by MPTP and free radical generation].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Dopamine; Humans; Hydroxyl Radical; Iron; Monoamine Oxidase; MPTP Poisoning; Oxidative Stress | 2001 |
Environmental estrogen-like chemicals and hydroxyl radicals induced by MPTP in the striatum: a review.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Environmental Pollutants; Estrogens, Non-Steroidal; Humans; Hydroxyl Radical; Parkinsonian Disorders | 2002 |
Dopamine efflux by MPTP and hydroxyl radical generation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Angiotensin-Converting Enzyme Inhibitors; Animals; Dopamine; Humans; Hydroxyl Radical; MPTP Poisoning; Neostriatum; Nitric Oxide; Oxidative Stress; Presynaptic Terminals | 2002 |
27 other study(ies) available for hydroxyl radical and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Article | Year |
|---|---|
Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clorgyline; Dialysis; Free Radicals; Hydroxides; Hydroxyl Radical; Rats; Selegiline | 1992 |
In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dialysis; Dopamine; Free Radicals; Hydroxides; Hydroxyl Radical; Male; Nerve Endings; Perfusion; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Substantia Nigra | 1992 |
Oxygen activation during the interaction between MPTP metabolites and synthetic neuromelanin--an ESR-spin trapping, optical, and oxidase electrode study.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Dopamine; Electrodes; Electron Spin Resonance Spectroscopy; Hydroxides; Hydroxyl Radical; Melanins; Oxidoreductases; Oxygen; Pyridines; Pyridinium Compounds | 1988 |
The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Cobalt; Dopamine; Drug Synergism; Free Radicals; Humans; Hydroxides; Hydroxyl Radical; Iron; Manganese; Metals; Oxidation-Reduction; Pyridines; Substantia Nigra; Superoxide Dismutase; Zinc | 1985 |
Monoamine oxidase, hydrogen peroxide, and Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Culture Techniques; Dopamine; Humans; Hydrogen Peroxide; Hydroxides; Hydroxydopamines; Hydroxyl Radical; Macaca fascicularis; Monoamine Oxidase; Neurons; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Superoxides | 1987 |
Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Calcium; Calcium Channels; Cell Death; Corpus Striatum; Dopamine; Free Radicals; Hydroxides; Hydroxyl Radical; Iron; Monoamine Oxidase; Nerve Degeneration; Neural Pathways; Oxidation-Reduction; Parkinson Disease, Secondary; Potassium; Potassium Channels; Rats; Substantia Nigra | 1993 |
Redox cycling of MPP+: evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aldehyde Dehydrogenase; Dihydrolipoamide Dehydrogenase; Electron Spin Resonance Spectroscopy; Hydroxides; Hydroxyl Radical; NAD; Oxidation-Reduction; Photolysis; Superoxides; Ultraviolet Rays; Xanthine Oxidase | 1993 |
Mitochondrial toxins in models of neurodegenerative diseases. I: In vivo brain hydroxyl radical production during systemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Azides; Brain; Disease Models, Animal; Dopamine Agents; Hydroxyl Radical; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurodegenerative Diseases; Pyridinium Compounds; Rats; Rats, Sprague-Dawley | 1997 |
Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Brain; Catalase; Disease Models, Animal; Glutathione Peroxidase; Glutathione Reductase; Humans; Hybrid Cells; Hydroxyl Radical; Mice; Mice, Inbred C57BL; Mitochondria; Neuroblastoma; Neurons; Oxidative Stress; Parkinson Disease, Secondary; Reactive Oxygen Species; Superoxide Dismutase; Tumor Cells, Cultured | 1997 |
Excessive iron accumulation in the brain: a possible potential risk of neurodegeneration in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Stem; Corpus Striatum; Glutathione; Glutathione Disulfide; Hydroxyl Radical; Iron; Iron, Dietary; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; Parkinson Disease; Risk Factors | 1997 |
Neuroprotection by bromocriptine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Bromocriptine; Dopamine Agents; Dopamine Agonists; Hydroxyl Radical; Mice; Mice, Inbred BALB C; Motor Neurons; Motor Skills Disorders; Substantia Nigra | 1998 |
Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspirin; Body Temperature; Corpus Striatum; Cyclooxygenase Inhibitors; Dexamethasone; Dopamine; Hydroxybenzoates; Hydroxyl Radical; Lysine; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; MPTP Poisoning; Salicylates; Salicylic Acid; Serotonin; Synaptosomes | 1998 |
Effects of nicotine on hydroxyl free radical formation in vitro and on MPTP-induced neurotoxicity in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Body Weight; Cardiotonic Agents; Cyclic N-Oxides; Dopamine; Dopamine Agents; Drug Interactions; Free Radical Scavengers; Hydroxyl Radical; Locomotion; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nitrogen Oxides; Parkinson Disease, Secondary | 1998 |
Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Animals; Azocines; Benzenesulfonates; Dopamine; Dopamine Agents; Hydroxyl Radical; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Degeneration; Neurons; Neuroprotective Agents; Quinolizines | 1998 |
Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Cysteine; Glutamic Acid; Glutathione; Glycine; Hydrolysis; Hydroxyl Radical; Iron; Kinetics; Male; Microdialysis; Mitochondria; Models, Chemical; Nitro Compounds; Oxygen Consumption; Parkinson Disease; Perfusion; Propionates; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1999 |
In vivo hydroxyl radical generation in the striatum following systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Catalase; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Electrochemistry; Glutathione; Hydroxybenzoates; Hydroxyl Radical; Mice; Mice, Inbred BALB C; Time Factors | 2000 |
Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Catalepsy; Cyclooxygenase Inhibitors; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Free Radical Scavengers; Gentisates; Glutathione; Homovanillic Acid; Hydroxybenzoates; Hydroxyl Radical; Male; Mice; Mice, Inbred BALB C; Monoamine Oxidase; MPTP Poisoning; Neostriatum; Neuroprotective Agents; Sodium Salicylate; Substantia Nigra | 2000 |
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Carrier Proteins; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Genetic Predisposition to Disease; Gentisates; Heterozygote; Homovanillic Acid; Hydroxybenzoates; Hydroxyl Radical; Male; Malonates; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Mitochondria; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurotoxins; Nitro Compounds; Propionates; Salicylic Acid; Superoxide Dismutase | 2001 |
Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biogenic Monoamines; Biotransformation; Dopamine; Dopamine Agents; Electrophoresis; Female; Hydroxyl Radical; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microdialysis; NF-kappa B; Oxidative Stress; Parkinson Disease, Secondary; Substantia Nigra; Tyrosine 3-Monooxygenase | 2001 |
D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Isomerism; Mice; Mice, Inbred BALB C; Monoamine Oxidase; Neostriatum; Neural Pathways; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Selegiline; Substantia Nigra | 2003 |
Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the mouse nigrostriatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell-Free System; Dopamine Agents; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutathione; Hydrogen Peroxide; Hydroxyl Radical; Iron; Melatonin; Mice; Mice, Inbred BALB C; Mitochondria; Oxidative Stress; Substantia Nigra; Superoxide Dismutase | 2004 |
Acetyl-L-carnitine prevents total body hydroxyl free radical and uric acid production induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcarnitine; Animals; Biomarkers; Gas Chromatography-Mass Spectrometry; Hydroxyl Radical; Male; MPTP Poisoning; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Uric Acid | 2004 |
A synthetic human proline-rich-polypeptide enhances hydroxyl radical generation and fails to protect dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced toxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electrochemistry; Humans; Hydroxyl Radical; Mice; Mice, Inbred BALB C; MPTP Poisoning; Neurons; Peptides; Proline; Proline-Rich Protein Domains; Time Factors; Treatment Failure | 2005 |
Synthetic bovine proline-rich-polypeptides generate hydroxyl radicals and fail to protect dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biogenic Amines; Cattle; Cell-Free System; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Hydroxyl Radical; Mice; Mice, Inbred BALB C; Mitochondria; MPTP Poisoning; Neurons; Neurotoxins; Parkinson Disease; Peptides; Proline-Rich Protein Domains | 2006 |
Effect of acute administration of hydroalcohol extract of Ilex paraguariensis St Hilaire (Aquifoliaceae) in animal models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Hydroxyl Radical; Ilex paraguariensis; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Parkinsonian Disorders; Plant Extracts; Reserpine | 2007 |
Taurine fails to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mitochondria; Neurodegenerative Diseases; Neurons; Taurine; Treatment Failure | 2008 |
Neuroprotective effects of 3-O-demethylswertipunicoside against MPTP-induced Parkinson's disease in vivo and its antioxidant properties in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Biphenyl Compounds; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glucosides; Hippocampus; Hydroxyl Radical; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Picrates; Spine; Superoxides; Tyrosine 3-Monooxygenase; Xanthones | 2015 |