Page last updated: 2024-09-04

hydroxyl radical and 1,10-phenanthroline

hydroxyl radical has been researched along with 1,10-phenanthroline in 31 studies

Compound Research Comparison

Studies
(hydroxyl radical)
Trials
(hydroxyl radical)
Recent Studies (post-2010)
(hydroxyl radical)
Studies
(1,10-phenanthroline)
Trials
(1,10-phenanthroline)
Recent Studies (post-2010) (1,10-phenanthroline)
10,147263,6571,6362466

Protein Interaction Comparison

ProteinTaxonomyhydroxyl radical (IC50)1,10-phenanthroline (IC50)
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))0.902
TPA: protein transporter TIM10Saccharomyces cerevisiae S288C12.3
TPA: protein transporter TIM23Saccharomyces cerevisiae S288C9.59

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19906 (19.35)18.7374
1990's18 (58.06)18.2507
2000's3 (9.68)29.6817
2010's4 (12.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jornot, L; Junod, AF; Petersen, H1
Keyse, SM; Tyrrell, RM1
Chang, WC; Chao, SC; Lickl, E1
Cochrane, CG; Hyslop, PA; Jackson, JH; Sauerheber, R; Schraufstatter, IU; Vosbeck, K; Weitzman, SA1
de Mello Filho, AC; Meneghini, R1
Bailey, CA; Hale, CC; Reeves, JP1
Boschero, AC; de Lúcio, MA; Eizirik, DL; Hoffmann, ME1
Gutteridge, JM; Halliwell, B1
Almeida, CE; Asad, LM; Asad, NR; Leitão, AC1
Hermes-Lima, M1
Burkitt, MJ1
Dreher, D; Junod, AF1
Lang, D; Stamminger, T1
Epe, B; Häring, M; Hegler, J; Pflaum, M; Rüdiger, H1
Behrman, HR; Musicki, B1
Burkitt, MJ; Milne, L; Nicotera, P; Orrenius, S1
Jiang, JJ; Liu, KJ; Mao, Y; Shi, X1
Hermann, T; Heumann, H1
Blakely, G; Sherratt, D1
Byrnes, RW1
Finta, C; Kiss, A1
Asad, NR; Furtado, FA; Leitão, AC1
Az-ma, T; Saeki, N; Yuge, O1
Cao, EH; Ma, WJ; Qin, JF1
Baba, M; Iishi, H; Mikuni, T; Narahara, H; Tatsuta, M; Uedo, N; Yano, H1
Bhowmick, T; Chakravarty, AR; Ramakumar, S; Roy, M; Santhanagopal, R1
Jiang, YL; Jiang, ZH; Liu, HL; Wang, QH1
Chen, H; Liao, X; Lu, J; Yang, N; Ying, P; Zeng, P1
Chan, CW; Chong, KV; Lai, JW; Maah, MJ; Ng, CH; Ooi, IH; Seng, HL1
Hatzidimitriou, AG; Papadopoulos, AN; Perontsis, S; Psomas, G1
Begou, OA; Hatzidimitriou, AG; Papadopoulos, AN; Perontsis, S; Psomas, G1

Reviews

1 review(s) available for hydroxyl radical and 1,10-phenanthroline

ArticleYear
How do Ca2+ and 5-aminolevulinic acid-derived oxyradicals promote injury to isolated mitochondria?
    Free radical biology & medicine, 1995, Volume: 19, Issue:3

    Topics: Aminolevulinic Acid; Animals; Calcium; Catalase; Dithiothreitol; Free Radicals; Hydroxyl Radical; Iron Chelating Agents; Mitochondria; Mitochondria, Liver; Oxidative Stress; Phenanthrolines; Rats; Superoxide Dismutase

1995

Other Studies

30 other study(ies) available for hydroxyl radical and 1,10-phenanthroline

ArticleYear
Differential protective effects of O-phenanthroline and catalase on H2O2-induced DNA damage and inhibition of protein synthesis in endothelial cells.
    Journal of cellular physiology, 1991, Volume: 149, Issue:3

    Topics: Adenosine Triphosphate; Animals; Aorta; Catalase; Cells, Cultured; DNA Damage; DNA, Single-Stranded; Endothelium, Vascular; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Kinetics; NAD; Phenanthrolines; Poly(ADP-ribose) Polymerases; Protein Biosynthesis; Swine

1991
Induction of the heme oxygenase gene in human skin fibroblasts by hydrogen peroxide and UVA (365 nm) radiation: evidence for the involvement of the hydroxyl radical.
    Carcinogenesis, 1990, Volume: 11, Issue:5

    Topics: Cell Survival; Deferoxamine; Fibroblasts; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Mixed Function Oxygenases; Phenanthrolines; RNA, Messenger; Skin; Ultraviolet Rays

1990
Intracellular oxidative cleavage of DNA in Escherichia coli by the copper-1,10-phenanthroline complex.
    Free radical research communications, 1989, Volume: 8, Issue:1

    Topics: DNA Damage; DNA, Bacterial; Escherichia coli; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Nucleic Acid Hybridization; Oxidation-Reduction; Phenanthrolines; Plasmids

1989
Role of oxidants in DNA damage. Hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:4

    Topics: Asbestos; Bacteriophages; Benzoates; Benzoic Acid; Catalase; Dihydropyridines; Dimethyl Sulfoxide; DNA; Drug Synergism; Electron Spin Resonance Spectroscopy; Hydroxides; Hydroxyl Radical; Mannitol; Nucleic Acid Conformation; Phenanthrolines; Smoking; Superoxide Dismutase; Thiazoles

1987
Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species.
    Biochimica et biophysica acta, 1985, Oct-30, Volume: 847, Issue:1

    Topics: Acetaldehyde; Animals; Cell Line; Cell Survival; Chelating Agents; Chemical Phenomena; Chemistry; DNA; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Fibroblasts; Free Radicals; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Iron Chelating Agents; Mice; Oxidation-Reduction; Phenanthrolines; Superoxides; Xanthine Oxidase

1985
Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles.
    The Journal of biological chemistry, 1986, Apr-15, Volume: 261, Issue:11

    Topics: Animals; Calcium; Carrier Proteins; Cattle; Disulfides; Dithiothreitol; Edetic Acid; Ferrous Compounds; Glutathione; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Myocardium; Oxidation-Reduction; Oxygen; Phenanthrolines; Sarcolemma; Sodium; Sodium-Calcium Exchanger; Superoxides

1986
1,10 phenanthroline, a metal chelator, protects against alloxan- but not streptozotocin-induced diabetes.
    Journal of free radicals in biology & medicine, 1986, Volume: 2, Issue:3

    Topics: Alloxan; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Hydroxides; Hydroxyl Radical; Iron Chelating Agents; Male; Methylurea Compounds; Phenanthrolines; Rats; Rats, Inbred Strains; Streptozocin

1986
The role of the superoxide and hydroxyl radicals in the degradation of DNA and deoxyribose induced by a copper-phenanthroline complex.
    Biochemical pharmacology, 1982, Sep-01, Volume: 31, Issue:17

    Topics: Biotransformation; Deoxyribose; DNA; Free Radicals; Hydroxides; Hydroxyl Radical; Mercaptoethanol; NAD; Oxygen; Phenanthrolines; Superoxides; Thiobarbiturates; Xanthine Oxidase

1982
Lethal interaction between hydrogen peroxide and o-phenanthroline in Escherichia coli.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1994, Volume: 27, Issue:11

    Topics: 2,2'-Dipyridyl; DNA; Escherichia coli; Hydrogen Peroxide; Hydroxyl Radical; Iron Chelating Agents; Phenanthrolines; Protease Inhibitors; Time Factors

1994
Copper--DNA adducts.
    Methods in enzymology, 1994, Volume: 234

    Topics: Copper; DNA; DNA Adducts; DNA Damage; Electron Spin Resonance Spectroscopy; Hydroxyl Radical; Indicators and Reagents; Iron; Kinetics; Oxidation-Reduction; Phenanthrolines

1994
Differential effects of superoxide, hydrogen peroxide, and hydroxyl radical on intracellular calcium in human endothelial cells.
    Journal of cellular physiology, 1995, Volume: 162, Issue:1

    Topics: Calcium; Cells, Cultured; Endothelium, Vascular; Homeostasis; Humans; Hydrogen Peroxide; Hydroxyl Radical; Hypoxanthine; Hypoxanthines; Oxidative Stress; Phenanthrolines; Superoxide Dismutase; Superoxides; Xanthine Oxidase

1995
Minor groove contacts are essential for an interaction of the human cytomegalovirus IE2 protein with its DNA target.
    Nucleic acids research, 1994, Aug-25, Volume: 22, Issue:16

    Topics: Antigens, Viral; Binding Sites; Copper; Cytomegalovirus; Deoxyribonuclease I; DNA; DNA, Viral; Gene Expression Regulation; Hydroxyl Radical; Immediate-Early Proteins; Methylation; Phenanthrolines; Promoter Regions, Genetic; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; TATA Box

1994
Use of repair endonucleases to characterize DNA damage induced by reactive oxygen species in cellular and cell-free systems.
    Toxicology letters, 1993, Volume: 67, Issue:1-3

    Topics: Acridine Orange; Animals; Cell-Free System; DNA Damage; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Free Radicals; Hydroxides; Hydroxyl Radical; Light; Metals; Mice; Oxidation-Reduction; Phenanthrolines; Photosensitizing Agents; Salmonella typhimurium; Swine

1993
Metal chelators reverse the action of hydrogen peroxide in rat luteal cells.
    Molecular and cellular endocrinology, 1993, Volume: 92, Issue:2

    Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Chelating Agents; Corpus Luteum; Cyclic AMP; Deferoxamine; Ethylenediamines; Female; Free Radical Scavengers; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Luteinizing Hormone; Penicillamine; Phenanthrolines; Progesterone; Rats; Rats, Inbred Strains; Receptors, LH; Signal Transduction

1993
1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions.
    The Biochemical journal, 1996, Jan-01, Volume: 313 ( Pt 1)

    Topics: Animals; Apoptosis; Calcium; Cell Nucleus; Chelating Agents; Copper; DNA; DNA Damage; Endonucleases; Enzyme Activation; Hydroxyl Radical; Intercalating Agents; Iron Chelating Agents; Liver; Magnesium; Male; Nucleosomes; Oxidation-Reduction; Phenanthrolines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical

1996
Generation of reactive oxygen species by Co(II) from H2O2 in the presence of chelators in relation to DNA damage and 2'-deoxyguanosine hydroxylation.
    Journal of toxicology and environmental health, 1996, Volume: 47, Issue:1

    Topics: Anserine; Azides; Chelating Agents; Chromatography, High Pressure Liquid; Cobalt; Deferoxamine; Deoxyguanosine; DNA Damage; Electron Spin Resonance Spectroscopy; Electrophoresis; Ethanol; Formates; Hydrogen Peroxide; Hydroxyl Radical; Hydroxylation; Mutagens; Oxidation-Reduction; Phenanthrolines; Reactive Oxygen Species; Sodium Azide; Spectrophotometry, Ultraviolet

1996
Determination of nucleotide distances in RNA by means of copper phenanthroline-generated hydroxyl radical cleavage pattern.
    RNA (New York, N.Y.), 1995, Volume: 1, Issue:10

    Topics: Anticodon; Binding Sites; Hydroxyl Radical; Models, Molecular; Molecular Probes; Molecular Structure; Nucleic Acid Conformation; Nucleotides; Phenanthrolines; RNA; RNA, Fungal; RNA, Transfer, Phe; Saccharomyces cerevisiae; Thermodynamics

1995
Determinants of selectivity in Xer site-specific recombination.
    Genes & development, 1996, Mar-15, Volume: 10, Issue:6

    Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Binding Sites; Chromosomes, Bacterial; DNA Footprinting; DNA Nucleotidyltransferases; DNA-Binding Proteins; DNA, Bacterial; DNA, Superhelical; Escherichia coli; Escherichia coli Proteins; Hydroxyl Radical; Integrases; Models, Genetic; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Phenanthrolines; Plasmids; Recombinases; Recombination, Genetic

1996
Evidence for involvement of multiple iron species in DNA single-strand scission by H2O2 in HL-60 cells.
    Free radical biology & medicine, 1996, Volume: 20, Issue:3

    Topics: Ascorbic Acid; Chelating Agents; Dimethyl Sulfoxide; DNA Damage; DNA, Neoplasm; DNA, Single-Stranded; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Hydrogen Peroxide; Hydroxyl Radical; Iron; Iron Chelating Agents; Kinetics; Phenanthrolines

1996
Footprint analysis of the bsp RI DNA methyltransferase-DNA interaction.
    Nucleic acids research, 1997, Jul-15, Volume: 25, Issue:14

    Topics: Copper; Deoxyribonuclease I; DNA; DNA Footprinting; DNA-Cytosine Methylases; Hydroxyl Radical; Mutagens; Phenanthrolines; Plasmids; Protease Inhibitors; Sulfuric Acid Esters

1997
Effects of 1,10-phenanthroline and hydrogen peroxide in Escherichia coli: lethal interaction.
    Mutation research, 1997, Volume: 385, Issue:3

    Topics: 2,2'-Dipyridyl; Benzoates; Benzoic Acid; Chelating Agents; Copper; Deferoxamine; Escherichia coli; Ethanol; Exodeoxyribonucleases; Ferric Compounds; Ferrous Compounds; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; Intercalating Agents; Iron; Oxidants; Phenanthrolines; Thiourea

1997
Cytosolic Ca2+ movements of endothelial cells exposed to reactive oxygen intermediates: role of hydroxyl radical-mediated redox alteration of cell-membrane Ca2+ channels.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cell Respiration; Cells, Cultured; Cyclic N-Oxides; Cytosol; Dithiothreitol; Endothelium, Vascular; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; Iron Chelating Agents; Nickel; Oxidants; Oxidation-Reduction; Phenanthrolines; Reactive Oxygen Species; Swine; Xanthine; Xanthine Oxidase

1999
The involvement of singlet oxygen in copper-phenanthroline/H2O2-induced DNA base damage: a chemiluminescent study.
    Redox report : communications in free radical research, 1999, Volume: 4, Issue:6

    Topics: Ascorbic Acid; DNA Damage; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; Luminescent Measurements; Oxygen; Phenanthrolines

1999
Suppression by iron chelator phenanthroline of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
    Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

    Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Apoptosis; Cell Division; Cocarcinogenesis; Drug Synergism; Electron Spin Resonance Spectroscopy; Hydroxyl Radical; Iron Chelating Agents; Lipid Peroxidation; Male; Methylnitronitrosoguanidine; Oxidation-Reduction; Phenanthrolines; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Sodium Chloride, Dietary; Stomach Neoplasms

2003
Photo-induced double-strand DNA and site-specific protein cleavage activity of L-histidine (mu-oxo)diiron(III) complexes of heterocyclic bases.
    Dalton transactions (Cambridge, England : 2003), 2009, Jun-28, Issue:24

    Topics: 2,2'-Dipyridyl; Calorimetry; Crystallography, X-Ray; DNA; DNA Cleavage; Ferric Compounds; Heterocyclic Compounds; Histidine; Hydrogen Bonding; Hydroxyl Radical; Iron; Models, Chemical; Models, Molecular; Molecular Conformation; Organometallic Compounds; Phenanthrolines; Photochemical Processes; Protein Binding; Proteins; Quinoxalines; Serum Albumin, Bovine; Thermodynamics; Transition Temperature

2009
Determination of hydroxyl radicals in TiO2/Ti photoelectrocatalytic oxidation system using Fe(phen)3(2+) spectrophotometry.
    Journal of environmental sciences (China), 2006, Volume: 18, Issue:1

    Topics: Catalysis; Electrochemistry; Ferrous Compounds; Hydrogen-Ion Concentration; Hydroxyl Radical; Oxidation-Reduction; Phenanthrolines; Photochemistry; Spectrum Analysis; Titanium

2006
New Oxidovanadium Complexes Incorporating Thiosemicarbazones and 1, 10-Phenanthroline Derivatives as DNA Cleavage, Potential Anticancer Agents, and Hydroxyl Radical Scavenger.
    Chemical biology & drug design, 2015, Volume: 86, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Cleavage; Free Radical Scavengers; Humans; Hydroxyl Radical; Neoplasms; Phenanthrolines; Thiosemicarbazones; Vanadates

2015
Enantiomeric pair of copper(II) polypyridyl-alanine complexes: Effect of chirality on their interaction with biomolecules.
    Journal of inorganic biochemistry, 2016, Volume: 160

    Topics: Alanine; Animals; Cations, Divalent; Cattle; Coordination Complexes; Copper; DNA; DNA Topoisomerases, Type I; Humans; Hydroxyl Radical; Phenanthrolines; Proteasome Endopeptidase Complex; Proteolysis; Pyridines; Serum Albumin; Stereoisomerism; Topoisomerase I Inhibitors

2016
Nickel-diflunisal complexes: synthesis, characterization, in vitro antioxidant activity and interaction with DNA and albumins.
    Journal of inorganic biochemistry, 2016, Volume: 162

    Topics: 2,2'-Dipyridyl; Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Binding, Competitive; Biphenyl Compounds; Cattle; Coordination Complexes; Crystallography, X-Ray; Diflunisal; DNA; Ethidium; Free Radical Scavengers; Hydroxyl Radical; Models, Molecular; Nickel; Phenanthrolines; Picrates; Protein Binding; Serum Albumin; Sulfonic Acids

2016
Characterization and biological properties of copper(II)-ketoprofen complexes.
    Journal of inorganic biochemistry, 2016, Volume: 162

    Topics: 2,2'-Dipyridyl; Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Binding, Competitive; Biphenyl Compounds; Cattle; Coordination Complexes; Copper; Crystallography, X-Ray; DNA; Ethidium; Free Radical Scavengers; Hydroxyl Radical; Ketoprofen; Models, Molecular; Phenanthrolines; Picrates; Protein Binding; Serum Albumin; Sulfonic Acids

2016