hydroxyitraconazole has been researched along with itraconazole in 81 studies
| Studies (hydroxyitraconazole) | Trials (hydroxyitraconazole) | Recent Studies (post-2010) (hydroxyitraconazole) | Studies (itraconazole) | Trials (itraconazole) | Recent Studies (post-2010) (itraconazole) |
|---|---|---|---|---|---|
| 87 | 29 | 22 | 6,440 | 653 | 2,357 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (27.16) | 18.2507 |
| 2000's | 35 (43.21) | 29.6817 |
| 2010's | 19 (23.46) | 24.3611 |
| 2020's | 5 (6.17) | 2.80 |
| Authors | Studies |
|---|---|
| Brandsteterová, E; Krcméry, V; Kubalec, P; Rády, A | 1 |
| Danger, P; Lacroix, C; Wojciechowski, F | 1 |
| Coronel, B; Dorez, D; Mercatello, A; Moskovtchenko, JF; Peins, MA; Persat, F | 1 |
| Cheymol, G; Descamps, P; Lebot, M; Levy, M; Poirier, JM | 1 |
| Denning, DW; Law, D; Moore, CB | 1 |
| Clemons, KV; Hanson, LH; Heykants, J; Hostetler, JS; Stevens, DA; Woestenborghs, R | 1 |
| Chandrasekar, PH; Ducharme, MP; Edwards, DJ; Mannens, G; Slaughter, RL; Van de Velde, V; Warbasse, LH | 1 |
| Cavalier, A; Elkhaili, H; Jehl, F; Kaltenbach, G; Levêque, D; Monteil, H; Peter, JD; Salmon, J; Salmon, Y | 1 |
| Compas, D; de Goede, PN; Touw, DJ | 1 |
| Bergmann, L; Böhme, A; Hoelzer, D; Just-Nübling, G; Shah, PM; Stille, W | 1 |
| Cheymol, G; Poirier, JM | 1 |
| Ajana, F; Bazin, C; Chwetzoff, E; Datry, A; Le Moing, JP; Levron, JC; Reynes, J | 1 |
| Cartledge, JD; Gazzard, BG; Midgely, J | 1 |
| Colardyn, F; De Beule, K; Decruyenaere, J; Groen, K; Jaqmin, P; Van Peer, A; Vandewoude, K; Vogelaers, D; Woestenborghs, R | 1 |
| Cornu, G; De Beule, K; de Repentigny, L; Jacqmin, P; Leclerc, JM; Ratelle, J; Sokal, EM | 1 |
| Bowman, J; Gubbins, PO; Gurley, BJ | 1 |
| Barone, JA; Bierman, RH; Colaizzi, JL; Guarnieri, J; Hassell, AE; Jessen, L; Moskovitz, BL | 1 |
| Baruch, A; Borum, J; Goldman, M; Hassell, AE; Lee, P; Pesco-Koplowitz, L; Wheat, LJ; Woestenborghs, R; Wu, J; Zhou, H | 1 |
| Ansorg, R; Dermoumi, H; Hülsewede, JW | 1 |
| Bozza, FA; Ponte, CG; Struchiner, CJ; Suarez-Kurtz, G; Vicente, FL | 1 |
| Kantola, T; Kivistö, KT; Neuvonen, PJ | 1 |
| Dupont, B; Odds, FC; Rinaldi, MG; Stevens, DA; Warnock, DW; Woestenborghs, R | 1 |
| Fukuda, M; Iizuka, T; Kume, H; Mochizuki, M; Murase, S; Shimada, S; Takahashi, K | 1 |
| Bossche, HV; Odds, FC | 1 |
| Archimbaud, E; Coronel, B; Dorez, D; Levron, JC; Mercatello, A; Van Devenne, A | 1 |
| Carrier, A; Parent, J | 1 |
| Brandsteterová, E; Kubalec, P | 1 |
| Archer, VC; Chosidow, O; Diquet, B; Lebrun-Vignes, B; Levron, JC; Puech, AJ; Warot, D | 1 |
| Al-Moshen, I; Al-Rawithi, S; Hussein, R; Raines, D | 1 |
| Baba, H; Iwasaki, H; Maezawa, Y; Takagi, K; Tsutani, H; Ueda, T; Yamashita, T; Yamauchi, T; Yoshida, A | 1 |
| Beijnen, JH; Crommentuyn, KM; Koks, CH; Lucassen, G; Sparidans, RW | 1 |
| Franks, AM; Gubbins, PO; Gurley, BJ; McConnell, SA; Melchert, RB; Penzak, SR | 1 |
| Beijnen, JH; Chuenyam, T; Huitema, AD; Koks, CH; Kroon, ED; Lange, JM; Sparidans, RW | 1 |
| Breadmore, MC; Thormann, W | 1 |
| Schiel, X; Spöhrer, U; Vogeser, M | 1 |
| Breadmore, MC; Procházková, A; Theurillat, R; Thormann, W | 1 |
| Delesen, H; Moeller, JG; Nagelschmitz, J; Stass, H | 1 |
| Dasgupta, AK; Datla, RR; Kale, P; Mavadhiya, C; Patel, M; Patel, R; Soni, D; Srivatsan, V | 1 |
| Beijnen, JH; Crommentuyn, KM; Huitema, AD; Mulder, JW; Schellens, JH; Sparidans, RW | 1 |
| Fincher, TK; Franks, AM; Gubbins, PO; Gurley, BJ; McConnell, SA; Penzak, SR; Saccente, M; Williams, DK | 1 |
| Conte, JE; Golden, JA; Kipps, J; McIver, M; Zurlinden, E | 1 |
| Fruehwirth, F; Khoschsorur, G; Zelzer, S | 1 |
| Charles, BG; Redmann, S | 1 |
| Shimizu, M; Sugawara, K; Tateishi, T; Uno, T | 1 |
| de Beule, K; Donnelly, JP; Mouton, JW; Soons, PA; van Peer, A; Van Vliet, A | 1 |
| Bell, SC; Charles, BG; Friberg, LE; Hennig, S; Miller, H; Wainwright, CE | 1 |
| Chi, SC; Nam, TY; Park, CW; Park, ES; Rhee, YS; Shin, YS | 1 |
| Hoffer, C; Isoherranen, N; Kharasch, ED; Kunze, KL; Nelson, WL; Templeton, IE; Thummel, KE | 1 |
| Abdel-Rahman, SM; Blumer, JL; Bradley, JS; Curtin, C; Jacobs, RF; Kauffman, RE; Kearns, GL; Kimko, HC; Maldonado, SD; Massarella, J; Shalayda, K | 1 |
| Bieber, T; Björkhem, I; Diczfalusy, U; Dullens, S; Gerdsen, R; Lütjohann, D; Neuvonen, PJ; Plat, J; Schneider, B; von Bergmann, K | 1 |
| Franks, AM; Gubbins, PO; Gurley, BJ; McConnell, SA; Penzak, SR; Saccente, M; Williams, DK | 1 |
| Chen, Y; Galinsky, RE; Hall, SD; Hamman, MA; Jiyamapa-Serna, VA; Kimura, RE; Quinney, SK | 1 |
| Bharathi, DV; Hotha, KK; Kumar, SS; Mullangi, R; Naidu, A; Reddy, PR; Sagar, PV | 1 |
| Aarnoutse, RE; Brüggemann, RJ; Burger, DM; Touw, DJ; Verweij, PE | 1 |
| Srinivas, NR; Yao, M | 1 |
| Abou-Madi, N; Bunting, EM; Cox, S; Fox, H; Kollias, GV; Martin-Jimenez, T | 1 |
| Jia, JY; Li, SJ; Liu, GY; Liu, YM; Lu, C; Wang, W; Weng, LP; Yu, C; Zhang, MQ | 1 |
| Borucka, B; Grabowski, T; Gumułka, SW; Sasinowska-Motyl, M; Sawicka, R; Swierczewska, A | 1 |
| Choi, YH; Kim, SH; Lee, BK; Lee, U | 1 |
| Bae, SK; Kim, EY; Mun, JH; Park, SJ; Shim, EJ; Shin, JG; Shon, JH | 1 |
| Backman, JT; Kurkinen, KJ; Neuvonen, PJ; Niemi, M; Tapaninen, T | 1 |
| Ohtani, H; Sawada, Y; Toi, A; Tsujimoto, M | 1 |
| Fujishima, N; Kagaya, H; Kameoka, Y; Miura, M; Nara, M; Saitoh, H; Sawada, K; Tagawa, H; Takahashi, N | 1 |
| Bille, J; Calandra, T; Decosterd, LA; Marchetti, O; Mercier, T; Pesse, B; Rochat, B; Tissot, F; Widmer, N; Zanolari, B | 1 |
| Buckner, SL; Ceesay, MM; Flanagan, RJ; Morgan, PE; Pagliuca, A | 1 |
| Backman, JT; Karonen, T; Laitila, J; Neuvonen, PJ; Niemi, M | 1 |
| Duan, J; Xiong, X; Zhai, S | 1 |
| Barclay, ML; Begg, EJ; Moore, GA; Zhang, M | 1 |
| Cendejas-Bueno, E; Cuenca-Estrella, M; Gomez-Lopez, A | 1 |
| Cheong, JW; Joo, YD; Kang, HJ; Kim, H; Kim, HG; Kim, HY; Kim, JS; Kim, JY; Kim, SH; Kim, YK; Kim, YS; Lee, DG; Lee, JH; Min, YH; Mun, YC; Park, J; Ryoo, HM; Yi, HG | 1 |
| Abuhelwa, AY; Foster, DJ; Hayes, D; Mudge, S; Upton, RN | 1 |
| Srinivas, NR | 1 |
| Aarnoutse, RE; Brüggemann, RJ; Burger, DM; Koenderink, JB; Lempers, VJ; Russel, FG; van den Heuvel, JJ | 1 |
| Basu, SS; Jarolim, P; Mason, DS; Petrides, A | 1 |
| Hashinaga, K; Hiramatsu, K; Itoh, H; Kadota, JI; Nonoshita, K; Oyama, N; Sato, Y; Suzuki, Y; Tanaka, R; Umeki, K | 1 |
| Bokonjić, D; Djordjević, S; Dragojević-Simić, V; Jaćević, V; Kilibarda, V; Kovačević, A; Mikov, M; Rančić, N | 1 |
| Matsumoto, K; Morita, K; Nakamura, Y; Sato, A | 1 |
| Ahn, C; Brekken, RA; Chembukar, V; DeBerardinis, RJ; Do, QN; Fattah, FJ; Faubert, B; Gerber, DE; Kallem, RR; Kasiri, S; Kernstine, KH; Kim, J; Leff, RD; Lenkinski, RE; Padmanabhan, C; Pedrosa, I; Pelosof, L; Putnam, WC; Reznik, SI; Saltarski, JM; Skelton, R; Subramaniyan, I; Xi, Y; Yuan, Q | 1 |
| Chen-Yoshikawa, TF; Date, H; Imai, S; Masuda, S; Matsubara, K; Matsuda, Y; Nagao, M; Nakagawa, S; Nakagawa, T; Omura, T; Sugimoto, M; Tsuda, M; Tsuzuki, T; Yamamoto, T; Yano, I; Yonezawa, A | 1 |
| Coutinho, AL; Kane, MA; Krug, SA; Polli, JE | 1 |
| Bazydlo, L; Girton, M; Tomsig, J | 1 |
1 review(s) available for hydroxyitraconazole and itraconazole
| Article | Year |
|---|---|
Bioanalytical methods for the determination of itraconazole and hydroxyitraconazole: overview from clinical pharmacology, pharmacokinetic, pharmacodynamic and metabolism perspectives.
Topics: Antifungal Agents; Humans; Itraconazole | 2009 |
28 trial(s) available for hydroxyitraconazole and itraconazole
| Article | Year |
|---|---|
Itraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoin.
Topics: Adult; Analysis of Variance; Anticonvulsants; Antifungal Agents; Chromatography, High Pressure Liquid; Fluorescence; Half-Life; Humans; Immunoassay; Itraconazole; Male; Phenytoin; Reference Values | 1995 |
Itraconazole for prophylaxis of systemic mycoses in neutropenic patients with haematological malignancies.
Topics: Administration, Oral; Adolescent; Adult; Aged; Agranulocytosis; Antifungal Agents; Female; Hematologic Neoplasms; Humans; Itraconazole; Male; Middle Aged; Mycoses; Prospective Studies | 1996 |
Pharmacokinetics of itraconazole (oral solution) in two groups of human immunodeficiency virus-infected adults with oral candidiasis.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Area Under Curve; Biological Availability; Candidiasis, Oral; Chromatography, High Pressure Liquid; Female; Humans; Itraconazole; Male; Middle Aged; Saliva | 1997 |
Concentrations in plasma and safety of 7 days of intravenous itraconazole followed by 2 weeks of oral itraconazole solution in patients in intensive care units.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adolescent; Adult; Antifungal Agents; beta-Cyclodextrins; Cyclodextrins; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Intensive Care Units; Itraconazole; Male; Middle Aged; Mycoses; Solutions | 1997 |
Enhanced bioavailability of itraconazole in hydroxypropyl-beta-cyclodextrin solution versus capsules in healthy volunteers.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Biological Availability; Capsules; Chemistry, Pharmaceutical; Cross-Over Studies; Humans; Itraconazole; Male; Middle Aged; Solutions | 1998 |
A pharmacokinetic study of intravenous itraconazole followed by oral administration of itraconazole capsules in patients with advanced human immunodeficiency virus infection.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Aged; Antifungal Agents; beta-Cyclodextrins; Cyclodextrins; Female; Humans; Injections, Intravenous; Itraconazole; Male; Middle Aged | 1998 |
Limited-sampling strategy models for itraconazole and hydroxy-itraconazole based on data from a bioequivalence study.
Topics: Adult; Antifungal Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Humans; Itraconazole; Male; Middle Aged; Therapeutic Equivalency | 1999 |
Effect of itraconazole on cerivastatin pharmacokinetics.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Itraconazole; Male; Placebos; Pyridines | 1999 |
Effect of itraconazole on the pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjects.
Topics: Adult; Antifungal Agents; Bodily Secretions; Cross-Over Studies; Drug Interactions; Glucocorticoids; Humans; Hydrocortisone; Itraconazole; Male; Methylprednisolone; Prednisolone | 2001 |
Population pharmacokinetics of itraconazole in Thai HIV-1-infected persons.
Topics: Adult; Antifungal Agents; Bayes Theorem; Biological Availability; Candidiasis, Oral; Cohort Studies; Dose-Response Relationship, Drug; HIV Infections; Humans; Itraconazole; Models, Biological; Thailand; Time Factors | 2003 |
Pharmacokinetics of moxifloxacin are not influenced by a 7-day pretreatment with 200 mg oral itraconazole given once a day in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Aza Compounds; Biological Availability; Cross-Over Studies; Drug Administration Schedule; Drug Therapy, Combination; Fasting; Fluoroquinolones; Germany; Humans; Itraconazole; Male; Moxifloxacin; Quinolines | 2004 |
Simultaneous determination of itraconazole and hydroxyitraconazole in human plasma by high-performance liquid chromatography.
Topics: Antifungal Agents; Buffers; Calibration; Chromatography, High Pressure Liquid; Freezing; Humans; Indicators and Reagents; Itraconazole; Quality Control; Reference Standards; Reproducibility of Results | 2004 |
Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteers.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adult; Antifungal Agents; Area Under Curve; beta-Cyclodextrins; Beverages; Biological Availability; Citrus paradisi; Cross-Over Studies; Cyclodextrins; Female; Food-Drug Interactions; Humans; Itraconazole; Male; Pharmaceutical Solutions | 2004 |
Sensitive determination of itraconazole and its active metabolite in human plasma by column-switching high-performance liquid chromatography with ultraviolet detection.
Topics: Adult; Antifungal Agents; Area Under Curve; Chloroform; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Fasting; Heptanes; Humans; Itraconazole; Male; Metabolic Clearance Rate; Reproducibility of Results; Spectrophotometry, Ultraviolet; Time Factors | 2006 |
Pharmacokinetics of itraconazole and hydroxyitraconazole in healthy subjects after single and multiple doses of a novel formulation.
Topics: Adult; Antifungal Agents; Area Under Curve; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Itraconazole; Male; Middle Aged; Nanoparticles | 2006 |
Population pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole in paediatric cystic fibrosis and bone marrow transplant patients.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Biological Availability; Bone Marrow Transplantation; Child; Child, Preschool; Computer Simulation; Cystic Fibrosis; Drug Administration Schedule; Female; Humans; Infant; Itraconazole; Male; Models, Biological; Population Surveillance; Reproducibility of Results | 2006 |
Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.
Topics: Administration, Oral; Adult; Antifungal Agents; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Female; Glucuronides; Humans; Itraconazole; Liver; Male; Models, Biological | 2008 |
Effects of high-dose itraconazole treatment on lipoproteins in men.
Topics: Antifungal Agents; Apolipoprotein A-I; Caco-2 Cells; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Hand Dermatoses; Humans; Itraconazole; Male; Middle Aged; Onychomycosis; Triglycerides | 2007 |
Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice.
Topics: Administration, Oral; Adult; Antifungal Agents; Area Under Curve; Beverages; Citrus paradisi; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Female; Food-Drug Interactions; Humans; Itraconazole; Male; Pharmaceutical Solutions; Sex Factors | 2008 |
Increased oral bioavailability of itraconazole and its active metabolite, 7-hydroxyitraconazole, when coadministered with a vitamin C beverage in healthy participants.
Topics: Adult; Antifungal Agents; Ascorbic Acid; Beverages; Biological Availability; Biotransformation; Cross-Over Studies; Female; Food-Drug Interactions; Half-Life; Humans; Itraconazole; Male; Miconazole; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Young Adult | 2011 |
Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren.
Topics: Adult; Amides; Antifungal Agents; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Fumarates; Half-Life; Humans; Itraconazole; Male; Metabolic Clearance Rate; Renin; Young Adult | 2011 |
Measurement of posaconazole, itraconazole, and hydroxyitraconazole in plasma/serum by high-performance liquid chromatography with fluorescence detection.
Topics: Adult; Aged; Antifungal Agents; Calibration; Chromatography, High Pressure Liquid; Cohort Studies; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Invasive Pulmonary Aspergillosis; Itraconazole; Limit of Detection; Male; Middle Aged; Neutropenia; Reproducibility of Results; Spectrometry, Fluorescence; Triazoles; Young Adult | 2011 |
Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations.
Topics: Adult; Anti-Asthmatic Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Fluconazole; Genetic Association Studies; Half-Life; Humans; Indoles; Itraconazole; Leukotriene Antagonists; Male; Phenylcarbamates; Polymorphism, Genetic; Sulfonamides; Tosyl Compounds; Young Adult | 2012 |
Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in fed and fasted states.
Topics: Administration, Oral; Adolescent; Adult; Capsules; Cross-Over Studies; Female; Healthy Volunteers; Humans; Itraconazole; Male; Middle Aged; Models, Theoretical; Young Adult | 2015 |
Prediction of area under the curve for a p-glycoprotein, a CYP3A4 and a CYP2C9 substrate using a single time point strategy: assessment using fexofenadine, itraconazole and losartan and metabolites.
Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Itraconazole; Losartan; Polypharmacy; Terfenadine | 2016 |
Sensitive and selective quantification of total and free itraconazole and hydroxyitraconazole in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Humans; Itraconazole; Mass Spectrometry; Pulmonary Aspergillosis | 2017 |
Bioequivalence study of two formulations of itraconazole 100 mg capsules in healthy volunteers under fed conditions: a randomized, three-period, reference-replicated, crossover study.
Topics: Administration, Oral; Adult; Antifungal Agents; Area Under Curve; Capsules; Cross-Over Studies; Female; Half-Life; Humans; Itraconazole; Male; Middle Aged; Therapeutic Equivalency; Young Adult | 2018 |
Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer.
Topics: Adult; Angiogenesis Inhibitors; Antineoplastic Agents; Biopsy; Carcinoma, Non-Small-Cell Lung; Female; Hedgehog Proteins; Humans; Itraconazole; Magnetic Resonance Imaging; Male; Middle Aged; Neovascularization, Pathologic; Patched-1 Receptor; Zinc Finger Protein GLI1 | 2020 |
52 other study(ies) available for hydroxyitraconazole and itraconazole
| Article | Year |
|---|---|
Determination of itraconazole and its metabolite in plasma using SPE-HPLC.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Itraconazole; Leukemia; Spectrophotometry, Ultraviolet | 1995 |
Simultaneous determination of itraconazole, hydroxy-itraconazole and amphotericin B in human plasma by HPLC with photodiode array detection.
Topics: Amphotericin B; Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Itraconazole; Mycoses | 1995 |
Itraconazole concentrations during continuous haemodiafiltration.
Topics: Acute Kidney Injury; Hemodiafiltration; Humans; Itraconazole; Male; Middle Aged | 1994 |
Determination of itraconazole and its active metabolite in plasma by column liquid chromatography.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Antifungal Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Itraconazole; Leukemia; Reproducibility of Results | 1994 |
Bioassay for serum itraconazole concentrations using hydroxyitraconazole standards.
Topics: Antifungal Agents; Biological Assay; Candida; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Itraconazole; Microbial Sensitivity Tests | 1994 |
Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: studies of interpatient variations in concentrations.
Topics: Acquired Immunodeficiency Syndrome; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Individuality; Itraconazole; Microbial Sensitivity Tests | 1993 |
[Pharmacokinetic interaction between itraconazole and rifampin in Yucatan miniature pigs].
Topics: Administration, Oral; Adult; Animals; Antibiotics, Antitubercular; Antifungal Agents; Catheterization, Peripheral; Disease Models, Animal; Drug Combinations; Female; Humans; Injections, Intravenous; Itraconazole; Rifampin; Swine | 1996 |
Rapid method for the analysis of itraconazole and hydroxyitraconazole in serum by high-performance liquid chromatography.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Drug Stability; Humans; Itraconazole; Reproducibility of Results; Sensitivity and Specificity | 1996 |
A rapid and specific liquid chromatographic assay for the determination of itraconazole and hydroxyitraconazole in plasma.
Topics: Antifungal Agents; Chromatography, Liquid; Humans; Itraconazole | 1997 |
Itraconazole solution: higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candidiasis, Oral; Capsules; Chemistry, Pharmaceutical; Cohort Studies; Humans; Itraconazole; Male; Solutions | 1997 |
Repeated-dose pharmacokinetics of an oral solution of itraconazole in infants and children.
Topics: Administration, Oral; Antifungal Agents; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Itraconazole; Male; Mycoses; Opportunistic Infections | 1998 |
Rapid and sensitive high performance liquid chromatographic method for the determination of itraconazole and its hydroxy-metabolite in human serum.
Topics: Antifungal Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Indicators and Reagents; Itraconazole; Quality Control; Reference Standards; Reproducibility of Results | 1998 |
Determination of itraconazole and hydroxy-itraconazole in sera using high-performance-liquid-chromatography and a bioassay.
Topics: Antifungal Agents; Biological Assay; Chromatography, High Pressure Liquid; Itraconazole; Paecilomyces | 1995 |
Bioassays for itraconazole blood levels: an interlaboratory collaborative study.
Topics: Antifungal Agents; Biological Assay; Chromatography, High Pressure Liquid; Humans; Itraconazole; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Serum itraconazole and hydroxyitraconazole concentrations and interaction with digoxin in a case of chronic hypertrophic pachymenigitis caused by Aspergillus flavus.
Topics: Aged; Antifungal Agents; Aspergillosis; Aspergillus flavus; Chronic Disease; Digoxin; Drug Interactions; Humans; Itraconazole; Male; Meningitis, Fungal; Serum Albumin | 2000 |
Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro.
Topics: Antifungal Agents; Candida; Fungi; Itraconazole; Microbial Sensitivity Tests; Trichophyton | 2000 |
Itraconazole lung concentrations in haematological patients.
Topics: Adult; Aged; Antifungal Agents; Chromatography, High Pressure Liquid; Female; Hematologic Neoplasms; Humans; Itraconazole; Lung; Male; Middle Aged | 2000 |
Liquid chromatographic-mass spectrometric determination of itraconazole and its major metabolite, hydroxyitraconazole, in dog plasma.
Topics: Animals; Antifungal Agents; Chromatography, High Pressure Liquid; Dogs; Itraconazole; Mass Spectrometry; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Column-switching chromatographic determination of itraconazole and its metabolite hydroxy-itraconazole in human serum.
Topics: Antifungal Agents; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Itraconazole; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2001 |
Expedient microdetermination of itraconazole and hydroxyitraconazole in plasma by high-performance liquid chromatography with fluorescence detection.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Fluorescence; Humans; Indicators and Reagents; Itraconazole; Reproducibility of Results | 2001 |
Successful treatment of Aspergillus spondylodiscitis with high-dose itraconazole in a patient with acute myelogenous leukemia.
Topics: Antifungal Agents; Aspergillosis; Discitis; Humans; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Treatment Outcome | 2001 |
Selective high-performance liquid chromatographic assay for itraconazole and hydroxyitraconazole in plasma from human immunodeficiency virus-infected patients.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; HIV Infections; Humans; Itraconazole; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2002 |
Effect of interleukin 6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes.
Topics: Adult; Cells, Cultured; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Hepatocytes; Humans; Interleukin-6; Itraconazole; Liver; Male; Middle Aged; Receptors, Interleukin-6 | 2003 |
Capillary electrophoresis evidence for the stereoselective metabolism of itraconazole in man.
Topics: beta-Cyclodextrins; Cyclodextrins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Monitoring; Electrophoresis, Capillary; Humans; Itraconazole; Methanol; Polyethylene Glycols; Stereoisomerism | 2003 |
Determination of itraconazole and hydroxyitraconazole in plasma by use of liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction.
Topics: Antifungal Agents; Automation; Chromatography, Liquid; Humans; Itraconazole; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Determination of itraconazole and hydroxyitraconazole in human serum and plasma by micellar electrokinetic chromatography.
Topics: Chromatography, High Pressure Liquid; Chromatography, Micellar Electrokinetic Capillary; Drug Monitoring; Humans; Itraconazole; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Antiretroviral Therapy, Highly Active; Drug Interactions; Drug Therapy, Combination; Histoplasmosis; HIV Infections; HIV Protease Inhibitors; Humans; Itraconazole; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir | 2004 |
Intrapulmonary pharmacokinetics and pharmacodynamics of itraconazole and 14-hydroxyitraconazole at steady state.
Topics: Adult; Antifungal Agents; Area Under Curve; Biotransformation; Bronchoalveolar Lavage Fluid; Epithelium; Female; Half-Life; Humans; Itraconazole; Lung; Male; Middle Aged; Prospective Studies; Pulmonary Alveoli; Specimen Handling | 2004 |
Isocratic high-performance liquid chromatographic method with ultraviolet detection for simultaneous determination of levels of voriconazole and itraconazole and its hydroxy metabolite in human serum.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Itraconazole; Pyrimidines; Reproducibility of Results; Sensitivity and Specificity; Triazoles; Ultraviolet Rays; Voriconazole | 2005 |
A rapid HPLC method with fluorometric detection for determination of plasma itraconazole and hydroxy-itraconazole concentrations in cystic fibrosis children with allergic bronchopulmonary aspergillosis.
Topics: Adolescent; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cystic Fibrosis; Female; Fluorometry; Humans; Infant; Itraconazole; Male; Reproducibility of Results; Sensitivity and Specificity | 2006 |
Formulation of parenteral microemulsion containing itraconazole.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antifungal Agents; Benzyl Alcohol; beta-Cyclodextrins; Castor Oil; Chemistry, Pharmaceutical; Emulsions; Ethanol; Excipients; Hemolysis; Injections, Intravenous; Itraconazole; Male; Particle Size; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Solubility; Solvents; Surface-Active Agents; Triglycerides; Water | 2007 |
Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adolescent; Antifungal Agents; beta-Cyclodextrins; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Itraconazole; Male; Mycoses | 2007 |
Hydroxyitraconazole, formed during intestinal first-pass metabolism of itraconazole, controls the time course of hepatic CYP3A inhibition and the bioavailability of itraconazole in rats.
Topics: Animals; Antifungal Agents; Biological Availability; Cytochrome P-450 CYP3A Inhibitors; Intestinal Mucosa; Itraconazole; Liver; Male; Rats; Rats, Sprague-Dawley | 2008 |
Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for simultaneous quantitation of itraconazole and hydroxyitraconazole in human plasma: application to a bioequivalence study.
Topics: Chromatography, Liquid; Humans; Itraconazole; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Therapeutic Equivalency | 2008 |
International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations.
Topics: Antifungal Agents; Azoles; Biological Assay; Fluconazole; Humans; Itraconazole; Pyrimidines; Triazoles; Voriconazole | 2009 |
Evaluation of oral itraconazole administration in captive Humboldt penguins (Spheniscus humboldti).
Topics: Administration, Oral; Animals; Animals, Zoo; Antifungal Agents; Area Under Curve; Aspergillosis; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Itraconazole; Species Specificity; Spheniscidae; Treatment Outcome | 2009 |
Simultaneous determination of itraconazole and hydroxyitraconazole in human plasma by liquid chromatography-isotope dilution tandem mass spectrometry method.
Topics: Chromatography, Liquid; Humans; Isotope Labeling; Itraconazole; Tandem Mass Spectrometry | 2010 |
Chromatographic/mass spectrometric method for the estimation of itraconazole and its metabolite in human plasma. Application to a bioequivalence study.
Topics: Adult; Antifungal Agents; Area Under Curve; Biotransformation; Calibration; Chromatography, High Pressure Liquid; Cross-Over Studies; Humans; Itraconazole; Male; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Therapeutic Equivalency; Young Adult | 2009 |
Pharmacokinetics of itraconazole in diabetic rats.
Topics: Animals; Antifungal Agents; Area Under Curve; Diabetes Mellitus, Experimental; Itraconazole; Male; Rats; Rats, Sprague-Dawley | 2010 |
Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolam.
Topics: Administration, Oral; Anti-Anxiety Agents; Antifungal Agents; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Humans; Itraconazole; Models, Biological; Time Factors; Triazolam | 2010 |
A simple, sensitive high-performance liquid chromatography -ultraviolet method for the quantification of concentration and steady-state pharmacokinetics of itraconazole and hydroxyitraconazole.
Topics: Blood Chemical Analysis; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; Itraconazole; Solid Phase Extraction; Ultraviolet Rays | 2010 |
Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and caspo
Topics: Anidulafungin; Antifungal Agents; Blood Chemical Analysis; Caspofungin; Chromatography, Liquid; Echinocandins; Humans; Itraconazole; Lipopeptides; Pyrimidines; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2010 |
Validation of a fast and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) with atmospheric pressure chemical ionization method for simultaneous quantitation of voriconazole, itraconazole and its active metabolite hydroxyitraconazole in h
Topics: Antifungal Agents; Antineoplastic Agents; Chromatography, Liquid; Drug Monitoring; Humans; Itraconazole; Liquid-Liquid Extraction; Pyrimidines; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2013 |
A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma.
Topics: Antifungal Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Itraconazole; Limit of Detection; Naproxen; Observer Variation; Pyrimidines; Reference Standards; Reproducibility of Results; Triazoles; Voriconazole | 2013 |
A simple, sensitive HPLC-PDA method for the quantification of itraconazole and hydroxy itraconazole in human serum: a reference laboratory experience.
Topics: Adult; Antifungal Agents; Blood Chemical Analysis; Child; Chromatography, High Pressure Liquid; Drug Stability; Humans; Itraconazole; Limit of Detection; Quality Control; Reference Standards | 2013 |
The relationship between the success rate of empirical antifungal therapy with intravenous itraconazole and clinical parameters, including plasma levels of itraconazole, in immunocompromised patients receiving itraconazole oral solution as prophylaxis: a
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antifungal Agents; Chemotherapy-Induced Febrile Neutropenia; Drug Monitoring; Female; Hematologic Neoplasms; Humans; Itraconazole; Male; Middle Aged; Mycoses; Prospective Studies; Treatment Outcome; Young Adult | 2014 |
Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP.
Topics: Amphotericin B; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Echinocandins; Fluconazole; HEK293 Cells; Humans; Itraconazole; Lipopeptides; Micafungin; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Triazoles; Voriconazole | 2016 |
A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum.
Topics: Antifungal Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Fluconazole; Humans; Itraconazole; Limit of Detection; Reproducibility of Results; Tandem Mass Spectrometry; Time Factors; Triazoles; Voriconazole | 2017 |
Effective plasma concentrations of itraconazole and its active metabolite for the treatment of pulmonary aspergillosis.
Topics: Aged; Aged, 80 and over; Antifungal Agents; Female; Humans; Itraconazole; Male; Middle Aged; Pulmonary Aspergillosis; Retrospective Studies; ROC Curve; Treatment Outcome | 2020 |
Effect of Itraconazole and Its Metabolite Hydroxyitraconazole on the Blood Concentrations of Cyclosporine and Tacrolimus in Lung Transplant Recipients.
Topics: Cyclosporine; Humans; Itraconazole; Lung; Retrospective Studies; Tacrolimus; Transplant Recipients | 2022 |
Validation of a method for itraconazole and major metabolite hydroxyitraconazole for LC-MS/MS analysis with application in a formulation clinical study.
Topics: Chromatography, Liquid; Humans; Itraconazole; Reproducibility of Results; Tandem Mass Spectrometry | 2023 |
Triazole Antifungal Quantification for Therapeutic Drug Monitoring in Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS): Posaconazole, Voriconazole, Itraconazole, and Hydroxyitraconazole.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Monitoring; Itraconazole; Methanol; Reproducibility of Results; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2024 |