hydroxyitraconazole has been researched along with aliskiren in 1 studies
| Studies (hydroxyitraconazole) | Trials (hydroxyitraconazole) | Recent Studies (post-2010) (hydroxyitraconazole) | Studies (aliskiren) | Trials (aliskiren) | Recent Studies (post-2010) (aliskiren) |
|---|---|---|---|---|---|
| 87 | 29 | 22 | 978 | 211 | 611 |
| Protein | Taxonomy | hydroxyitraconazole (IC50) | aliskiren (IC50) |
|---|---|---|---|
| Renin | Homo sapiens (human) | 0.001 | |
| Renin-1 | Mus musculus (house mouse) | 0.0045 | |
| Renin | Rattus norvegicus (Norway rat) | 0.084 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.0004 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.0023 | |
| Renin | Macaca mulatta (Rhesus monkey) | 0.0012 | |
| Renin | Oryctolagus cuniculus (rabbit) | 0.011 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Backman, JT; Kurkinen, KJ; Neuvonen, PJ; Niemi, M; Tapaninen, T | 1 |
1 trial(s) available for hydroxyitraconazole and aliskiren
| Article | Year |
|---|---|
Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren.
Topics: Adult; Amides; Antifungal Agents; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Fumarates; Half-Life; Humans; Itraconazole; Male; Metabolic Clearance Rate; Renin; Young Adult | 2011 |