hydroxyindoleacetic acid has been researched along with n-methyl-3,4-methylenedioxyamphetamine in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (12.60) | 18.7374 |
| 1990's | 53 (41.73) | 18.2507 |
| 2000's | 42 (33.07) | 29.6817 |
| 2010's | 16 (12.60) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goromaru, T; Hashimoto, K; Maeda, H | 2 |
| Gibb, JW; Hanson, GR; Johnson, M; Mitros, K; Stone, DM; Zobrist, R | 1 |
| Katz, JL; Martello, AL; Martello, MB; Ricaurte, GA | 1 |
| Culp, S; DeSouza, EB; Lehmann, J; Zaczek, R | 1 |
| McCann, UD; Ricaurte, GA | 1 |
| Katz, JL; Ricaurte, GA; Steele, TD | 1 |
| Gudelsky, GA; Meltzer, HY; Nash, JF | 1 |
| Cho, AK; Hiramatsu, M | 1 |
| Goromaru, T; Hashimoto, K | 2 |
| Gaylor, DW; Slikker, W | 2 |
| Finnegan, KT; Irwin, I; Langston, JW; Ricaurte, GA | 1 |
| Arora, RC; Meltzer, HY; Nash, JF; Schreiber, MA | 1 |
| Cunningham, KA; Paris, JM | 1 |
| Ali, SF; Gough, B; Holson, RR; Slikker, W | 1 |
| Hsu, FL; Yeh, SY | 1 |
| Dornan, WA; Katz, JL; Ricaurte, GA | 1 |
| Chang, AS; Cho, AK; DiStefano, E; Hiramatsu, M | 1 |
| Huang, XM; Johnson, MP; Nichols, DE | 1 |
| Lovenberg, W; Schmidt, CJ; Wu, L | 1 |
| Schmidt, CJ | 1 |
| Battaglia, G; De Souza, EB; Kuhar, MJ; Molliver, ME; O'Hearn, E; Yeh, SY | 1 |
| Gibb, JW; Hanson, GR; Stone, DM | 1 |
| Gibb, JW; Hanson, GR; Stahl, DC; Stone, DM | 1 |
| Battaglia, G; De Souza, EB; Yeh, SY | 1 |
| DeLanney, LE; Forno, LS; Irwin, I; Langston, JW; Molliver, ME; Ricaurte, GA; Wilson, MA | 1 |
| Ali, SF; Bailey, JR; Frith, CH; Newport, GD; Scallet, AC; Slikker, W | 1 |
| DeLanney, LE; Irwin, I; Langston, JW; Ricaurte, GA; Wiener, SG | 1 |
| Schmidt, CJ; Taylor, VL | 1 |
| Bush, LG; Gibb, JW; Hanson, GR; Johnson, M; Stone, DM | 1 |
| Battaglia, G; De Souza, EB; Insel, TR; Johannessen, JN; Marra, S | 1 |
| Gibb, JW; Hanson, GR; Johnson, M; Letter, AA; Merchant, K | 1 |
| Kleven, MS; Seiden, LS; Woolverton, WL | 1 |
| Lowy, MT; Meltzer, HY; Nash, JF | 1 |
| Johnson, MP; Nichols, DE | 1 |
| Colado, MI; Green, AR | 2 |
| McCann, UD; Ricaurte, GA; Ridenour, A; Shaham, Y | 1 |
| Farfel, GM; Seiden, LS | 1 |
| Cowen, PJ; Series, HG; Sharp, T | 1 |
| Nichols, DE; Sprague, JE | 2 |
| Green, AR; Hewitt, KE | 1 |
| Colado, MI; Green, AR; Williams, JL | 1 |
| Hatzidimitriou, G; Katz, JL; Martello, AL; Ricaurte, GA; Scanzello, CR | 1 |
| Colado, MI; Green, AR; Murray, TK | 1 |
| Hashimoto, K | 1 |
| Aguirre, N; Del Río, J; Galbete, JL; Lasheras, B | 1 |
| Gartside, SE; McQuade, R; Sharp, T | 1 |
| Johnson, MP; Nichols, DE; Schmidt, CJ; Sprague, JE | 1 |
| Finnegan, KT; Taraska, T | 1 |
| Laverty, R; Russell, B; Schmierer, D; Zheng, Y | 1 |
| Colado, MI; Granados, R; Green, AR; Misra, A; Murray, TK; O'Shea, E | 1 |
| Ashby, CR; Granoff, MI | 1 |
| Connor, TJ; Currid, A; Finn, D; Kelly, JP; Leonard, BE; McNamara, MG; O'Malley, M; Redmond, AM | 1 |
| Laverty, R; Zheng, Y | 1 |
| Malberg, JE; Seiden, LS | 1 |
| Colado, MI; Esteban, B; Granados, R; Green, AR; O'Shea, E | 3 |
| Aguirre, N; Ballaz, S; Del Río, J; Lasheras, B | 1 |
| Bolla, KI; McCann, UD; Ricaurte, GA | 1 |
| Yeh, SY | 1 |
| Eligulashvili, V; McCann, UD; Mertl, M; Ricaurte, GA | 1 |
| Andrews, AM; Cadet, JL; Jayanthi, S; Ladenheim, B | 1 |
| Cadet, JL; Dersch, C; Rothman, R; Yeh, SY | 1 |
| Gamma, A; Huber, T; Liechti, M; Vollenweider, FX | 1 |
| Baker, LE; Byrne, T; Poling, A | 1 |
| Ang, L; Furukawa, Y; Kalasinsky, KS; Kish, SJ; Vorce, SP | 1 |
| Aguirre, N; Hervías, I; Lasheras, B | 1 |
| Davis, S; Gold, LH; Henriksen, SJ; Huitrón-Resendiz, S; Parsons, LH; Schroeder, R; Taffe, MA; Weed, MR | 1 |
| Callahan, BT; Cord, BJ; Ricaurte, GA | 1 |
| Camarero, J; Colado, MI; Esteban, B; Green, AR; O'Shea, E; Sanchez, V | 1 |
| Colado, MI; Elliott, JM; Green, AR; Mechan, AO; O'Shea, E | 1 |
| Kovar, KA; Mayerhofer, A; Schmidt, WJ | 1 |
| Delatte, MS; McCann, UD; Moerschbaecher, JM; Ricaurte, GA; Stevenson, MW; Winsauer, PJ; Yuan, J | 1 |
| Johnson, EA; Miller, DB; O'Callaghan, JP | 1 |
| Easton, N; Fry, JR; Green, AR; Marsden, CA; O'Shea, E | 1 |
| Bäumer, T; Buhmann, C; Petersen, K; Rosenkranz, M; Stuerenburg, HJ; Thomasius, R | 1 |
| Ali, SF; Meyer, JS | 1 |
| Ali, SF; Blough, B; Gough, B; Imam, SZ; Slikker, W | 1 |
| Cord, BJ; Hatzidimitriou, G; McCann, UD; Ricaurte, GA; Yuan, J | 1 |
| Callahan, BT; Cord, BJ; McCann, UD; Ricaurte, GA; Yuan, J | 1 |
| Boot, BP; McCann, UD; Mechan, AO; Ricaurte, GA | 1 |
| Davis, SA; Gold, LH; Hatzidimitriou, G; Parsons, LH; Ricaurte, GA; Schroeder, R; Taffe, MA; Yuan, J | 1 |
| Bull, EJ; Fone, KC; Hutson, PH | 1 |
| Clemens, KJ; Cornish, JL; Hunt, GE; Li, KM; McGregor, IS; Van Nieuwenhuyzen, PS | 1 |
| Baumann, MH; Rothman, RB; Wang, X; Xu, H | 1 |
| Colado, MI; Elliott, JM; Green, AR; O'shea, E; Saadat, KS; Sanchez, V | 1 |
| Cornish, JL; Li, KM; McGregor, IS; Morley, KC | 1 |
| Colado, MI; Escobedo, I; Green, AR; Navarro, M; O'Shea, E; Orio, L; Sanchez, V | 1 |
| Freezer, A; Irvine, RJ; Salem, A | 1 |
| Ben Hamida, S; Cassel, JC; Jeltsch, H; Jones, BC; Kelche, C; Koenig, J; Lazarus, C; Riegert, C | 1 |
| Clemens, KJ; Cornish, JL; Hunt, GE; Li, KM; McGregor, IS | 1 |
| Colado, MI; Escobedo, I; Green, AR; O'Shea, E; Orio, L; Sanchez, V | 1 |
| Harkin, A; Kerans, A; McNamara, R; O'Neill, B | 1 |
| Baumann, MH; Rothman, RB; Zolkowska, D | 1 |
| Camarero, J; Colado, MI; Escobedo, I; Green, AR; O'Shea, E; Orio, L; Sanchez, V | 1 |
| Hashimoto, K; Iyo, M; Shimizu, E; Shirayama, Y; Zhang, L | 1 |
| Elliott, JM; Green, AR; Moran, PM; Saadat, KS | 1 |
| Callaghan, PD; Daws, LC; Farrand, K; Hughes, P; Irvine, RJ; Salem, A | 1 |
| Francis, R; Jotwani, RP; Kuhn, CM; Walker, QD; Waller, ST; Williams, CN | 1 |
| Irvine, RJ; Salem, A; Stanley, N | 1 |
| Hewton, R; Irvine, RJ; Salem, A | 1 |
| Aguirre, N; de la Torre, R; Goni-Allo, B; Lasheras, B; O Mathúna, B; Puerta, E; Segura, M | 1 |
| Aguirre, N; de la Torre, R; Goñi-Allo, B; Hervias, I; Lasheras, B; Mathúna, BO; Puerta, E | 1 |
| Ashford, KA; Christie, IN; Evans, AK; Lowry, CA; Reinders, N; Wakerley, JB | 1 |
| Alves, CJ; Alves, E; Binienda, Z; Carvalho, F; de Lourdes Bastos, M; Fernandes, E; Summavielle, T; Tavares, MA | 1 |
| Aguirre, N; Goñi-Allo, B; Hervias, I; Jordan, J; Lasheras, B; Puerta, E | 1 |
| Cadet, JL; Huestis, MA; Ladenheim, B; Scheidweiler, KB | 1 |
| von Ameln, N; von Ameln-Mayerhofer, A | 1 |
| Ali, SF; Daniels, LG; Meyer, JS; Piper, BJ | 1 |
| Irvine, RJ; Jaehne, EJ; Majumder, I; Salem, A | 1 |
| Aguilar, MA; Armario, A; Do Couto, BR; Fuentes, S; Gagliano, H; Miñarro, J; Rodríguez-Arias, M | 1 |
| Largeron, M; Martinez, CM; McCann, U; Mechan, A; Mueller, M; Neudörffer, A; Ricaurte, GA | 1 |
| Goiny, M; Ichinose, F; Kehr, J; Nyberg, F; Sievertsson, T; Yoshitake, S; Yoshitake, T | 1 |
| Buwalda, B; Grahlmann, C; Granneman, RA; Koolhaas, JM; Wallinga, AE | 1 |
| Ali, SF; Meyer, JS; Shen, EY | 1 |
| Irvine, RJ; Majumder, I; White, JM | 1 |
| Aguilar, MA; Miñarro, J; Rodríguez-Arias, M; Vidal-Infer, A | 1 |
| Ali, SF; Biezonski, DK; Kim, PJ; Meyer, JS; Piper, BJ; Shinday, NM | 1 |
| Behan, B; Blau, CW; Byrne, D; Campbell, M; Duffy, P; Gigliucci, V; Gobbo, OL; Harkin, A; Kelly, ME; Kerskens, CM; McHugh Smith, K; Ogden, I; Rouine, J | 1 |
| Cichon, T; Cox, BM; Galloway, MP; Perrine, SA; Shah, MM; Tancer, ME; Thomas, DM | 1 |
| Cholanians, AB; Herndon, JM; Lau, SS; Lizarraga, LE; Monks, TJ; Phan, AV | 1 |
| Aoki, Y; Ishiba, A; Kato, H; Maeno, Y; Matsumoto, T; Monma-Ohtaki, J; Nagao, M; Seko-Nakamura, Y | 1 |
1 review(s) available for hydroxyindoleacetic acid and n-methyl-3,4-methylenedioxyamphetamine
| Article | Year |
|---|---|
Neurotoxic amphetamine analogues: effects in monkeys and implications for humans.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Central Nervous System; Designer Drugs; Haplorhini; Humans; Hydroxyindoleacetic Acid; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxins; Rats; Species Specificity | 1992 |
1 trial(s) available for hydroxyindoleacetic acid and n-methyl-3,4-methylenedioxyamphetamine
| Article | Year |
|---|---|
Serotonin neurotoxicity after (+/-)3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy"): a controlled study in humans.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Analysis of Variance; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Illicit Drugs; Male; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Pain; Pain Measurement; Personality Tests; Prolactin; Serotonin | 1994 |
125 other study(ies) available for hydroxyindoleacetic acid and n-methyl-3,4-methylenedioxyamphetamine
| Article | Year |
|---|---|
Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Quipazine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 1992 |
Effect of flunarizine and nimodipine on the decrease in tryptophan hydroxylase activity induced by methamphetamine and 3,4-methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Chromatography, High Pressure Liquid; Diltiazem; Drug Interactions; Enzyme Induction; Flunarizine; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nimodipine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Serotonin; Tryptophan Hydroxylase | 1992 |
Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dopamine; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Norepinephrine; Paroxetine; Piperidines; Saimiri; Serotonin; Serotonin Antagonists | 1992 |
Regional distribution to recovery of 5-HT levels after administration of "atrophins" MDMA and D,L-fenfluramine. Stereospecificity and comparison with 5,7-dihydroxytryptamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Atrophy; Brain; Cerebral Ventricles; Designer Drugs; Dopamine; Fenfluramine; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Organ Specificity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism | 1992 |
Evaluation of the neurotoxicity of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine, PMMA).
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; Hallucinogens; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Rats; Rats, Sprague-Dawley; Serotonin; Structure-Activity Relationship | 1992 |
Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Designer Drugs; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Rats; Rats, Wistar; Serotonin | 1992 |
Effect of 3,4-methylenedioxymethamphetamine on 3,4-dihydroxyphenylalanine accumulation in the striatum and nucleus accumbens.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Ketanserin; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Serotonin; Serotonin Antagonists | 1990 |
Enantiomeric differences in the effects of 3,4-methylenedioxymethamphetamine on extracellular monoamines and metabolites in the striatum of freely-moving rats: an in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Electrochemistry; Fenclonine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism | 1990 |
Reduction of in vivo binding of [3H]paroxetine in mouse brain by 3,4-methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hydroxyindoleacetic Acid; Injections, Intravenous; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists | 1990 |
Risk assessment for neurotoxic effects.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Axons; Designer Drugs; Female; Hippocampus; Hydroxyindoleacetic Acid; Macaca mulatta; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Rats; Rats, Inbred Strains; Risk; Serotonin | 1990 |
Aminergic metabolites in cerebrospinal fluid of humans previously exposed to MDMA: preliminary observations.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Biogenic Amines; Designer Drugs; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Reference Values; Substance-Related Disorders | 1990 |
Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Blood Platelets; Frontal Lobe; Hydroxyindoleacetic Acid; Ketanserin; Kinetics; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Time Factors; Tritium | 1991 |
Reduction of [3H]6-nitroquipazine-labelled 5-hydroxytryptamine uptake sites in rat brain by 3,4-methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Binding Sites; Brain; Drug Interactions; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Quipazine; Radioligand Assay; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tritium | 1990 |
Lack of neurotoxicity after intra-raphe micro-injections of MDMA ("ecstasy").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Immunohistochemistry; Indoles; Male; Microinjections; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin | 1990 |
Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Caudate Nucleus; Chromatography, High Pressure Liquid; Dialysis; Dopamine; Electrochemistry; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; In Vitro Techniques; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin | 1991 |
The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Central Nervous System Stimulants; Cerebral Cortex; Deoxyepinephrine; Dopamine; Epinephrine; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nordefrin; Rats; Rats, Inbred Strains; Serotonin | 1991 |
The effects of repeated administration of MDMA on the expression of sexual behavior in the male rat.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Corpus Striatum; Ejaculation; Hippocampus; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Serotonin; Sexual Behavior, Animal | 1991 |
A pharmacokinetic analysis of 3,4-methylenedioxymethamphetamine effects on monoamine concentrations in brain dialysates.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Biological Availability; Brain Chemistry; Corpus Striatum; Dialysis; Dopamine; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Isomerism; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Amphetamine; Animals; Brain; Dopamine; Dopamine Agents; Homovanillic Acid; Hydroxyindoleacetic Acid; Indans; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Serotonin | 1991 |
Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin; Time Factors | 1986 |
Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cerebral Cortex; Fluoxetine; Hydroxyindoleacetic Acid; Kinetics; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Time Factors | 1987 |
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Brain Chemistry; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tritium | 1987 |
Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Amines; Brain; Corpus Striatum; Hippocampus; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred Strains; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Species Specificity; Time Factors; Tryptophan Hydroxylase | 1987 |
The effects of amphetamine-like designer drugs on monoaminergic systems in rat brain.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin; Tryptophan Hydroxylase | 1987 |
MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biological Transport, Active; Brain; Dose-Response Relationship, Drug; Guinea Pigs; Hydroxyindoleacetic Acid; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Regeneration; Neurons; Rats; Rats, Inbred Strains; Serotonin; Species Specificity | 1988 |
(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Dose-Response Relationship, Drug; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Macaca fascicularis; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Fibers; Neurons; Raphe Nuclei; Saimiri; Serotonin | 1988 |
Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA).
Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Amphetamines; Animals; Brain; Brain Chemistry; Dopamine; Female; Hydroxyindoleacetic Acid; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Species Specificity | 1988 |
5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cebidae; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Serotonin | 1988 |
Direct central effects of acute methylenedioxymethamphetamine on serotonergic neurons.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cerebral Cortex; Hydroxyindoleacetic Acid; In Vitro Techniques; Infusions, Parenteral; Injections; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Tryptophan Hydroxylase; Tumor Cells, Cultured | 1988 |
Glucocorticoids and 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Adrenalectomy; Amphetamines; Animals; Cerebral Cortex; Corticosterone; Glucocorticoids; Hippocampus; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Rats; Rats, Inbred Strains; Serotonin; Tryptophan Hydroxylase | 1989 |
3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Norepinephrine; Serotonin | 1989 |
Effects of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine isomers on central serotonergic, dopaminergic and nigral neurotensin systems of the rat.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotensin; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Substantia Nigra; Tryptophan Hydroxylase | 1988 |
Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Macaca; Macaca mulatta; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin | 1989 |
Selective reduction of striatal type II glucocorticoid receptors in rats by 3,4-methylenedioxymethamphetamine (MDMA).
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Androstanols; Animals; Corpus Striatum; Corticosterone; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Serotonin | 1989 |
Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Brain Chemistry; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1989 |
A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; 4-Butyrolactone; Animals; Brain; Chlormethiazole; Designer Drugs; Dizocilpine Maleate; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Ondansetron; Pentobarbital; Rats; Serotonin | 1994 |
Modeling for risk assessment of neurotoxic effects.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Confidence Intervals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Haplorhini; Hydroxyindoleacetic Acid; Male; Maximum Allowable Concentration; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Reference Values; Risk Factors; Serotonin; Species Specificity | 1994 |
Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX.
Topics: Animals; Body Temperature; Brain Chemistry; Dizocilpine Maleate; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Pipecolic Acids; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin | 1995 |
p-Chloroamphetamine (PCA), 3,4-methylenedioxy-methamphetamine (MDMA) and d-fenfluramine pretreatment attenuates d-fenfluramine-evoked release of 5-HT in vivo.
Topics: Amphetamines; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Dextroamphetamine; Fenfluramine; Hydroxyindoleacetic Acid; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; p-Chloroamphetamine; Potassium; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin | 1994 |
The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits.
Topics: Animals; Brain; Hydroxyindoleacetic Acid; Lipid Peroxidation; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Selegiline; Serotonin; Synaptosomes; Tryptophan Hydroxylase | 1995 |
Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats.
Topics: Animals; Chlormethiazole; Dizocilpine Maleate; Haloperidol; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Neuroprotective Agents; Radioligand Assay; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin | 1994 |
Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum.
Topics: Animals; Corpus Striatum; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selegiline; Serotonin; Sodium Chloride | 1995 |
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature Regulation; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Fever; Humans; Hydroxyindoleacetic Acid; Male; Mixed Function Oxygenases; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Phenotype; Proadifen; Quinidine; Rats; Rectum; Serotonin; Serotonin Agents; Sex Factors; Tritium | 1995 |
Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Axons; Brain Chemistry; Hydroxyindoleacetic Acid; Immunohistochemistry; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin | 1993 |
5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Cerebral Cortex; Chlormethiazole; Dizocilpine Maleate; Fenfluramine; Hippocampus; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; p-Chloroamphetamine; Rats; Serotonin | 1993 |
Effects of benzylpiperazine derivatives on the acute effects of 3,4-methylenedioxymethamphetamine in rat brain.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Desipramine; Hydroxyindoleacetic Acid; Imipramine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptosomes | 1993 |
The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones.
Topics: Analysis of Variance; Animals; Binding, Competitive; Cerebral Cortex; Cyclic N-Oxides; Free Radicals; Hippocampus; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Neurons, Afferent; Nitrogen Oxides; Paroxetine; Rats; Serotonin; Serotonin Antagonists; Spin Labels | 1995 |
Methylenedioxymethamphetamine induces opposite changes in central pre- and postsynaptic 5-HT1A receptors in rats.
Topics: Animals; Dendrites; Frontal Lobe; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Agents; Synapses; Time Factors | 1995 |
Effects of repeated administration of 3,4-methylenedioxymethamphetamine on 5-hydroxytryptamine neuronal activity and release in the rat brain in vivo.
Topics: Animals; Brain; Frontal Lobe; Hippocampus; Hydroxyindoleacetic Acid; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents | 1996 |
Studies on the mechanism of p-chloroamphetamine neurotoxicity.
Topics: Animals; Brain; Clorgyline; Dopamine; Fever; Hydroxyindoleacetic Acid; Indans; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Neurotoxins; p-Chloroamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin; Serotonin Agents | 1996 |
Nitric oxide and the neurotoxic effects of methamphetamine and 3,4-methylenedioxymethamphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Body Temperature; Brain; Catecholamines; Corpus Striatum; Dopamine; Frontal Lobe; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Isosorbide Dinitrate; Male; Methamphetamine; Mice; Mice, Inbred Strains; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Serotonin | 1997 |
The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aminorex; Animals; Appetite Depressants; Biogenic Monoamines; Brain Chemistry; Dopamine; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred CBA; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin | 1997 |
A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy.
Topics: Animals; Body Temperature; Body Weight; Brain; Dopamine; Female; Hydroxyindoleacetic Acid; Lipid Peroxidation; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Pregnancy; Rats; Rats, Wistar; Serotonin; Serotonin Agents | 1997 |
The effect of the repeated administration of the compound 3,4-methylenedioxymethamphetamine on the response of rats to the 5-HT2A,C receptor agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI).
Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Serotonin Receptor Agonists | 1998 |
Acute 3,4-methylenedioxymethamphetamine(MDMA) administration produces a rapid and sustained suppression of immune function in the rat.
Topics: Animals; Cerebral Cortex; Concanavalin A; Corticosterone; Female; Hallucinogens; Hydroxyindoleacetic Acid; Immunity, Cellular; Leukocyte Count; Lymphocyte Activation; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; T-Lymphocytes; Time Factors | 1998 |
Role of brain nitric oxide in (+/-)3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats.
Topics: Animals; Body Temperature; Enzyme Activation; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Indazoles; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents | 1998 |
Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Body Temperature Regulation; Brain Chemistry; Corpus Striatum; Dopamine; Fever; Frontal Lobe; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Sodium Chloride; Somatosensory Cortex; Temperature | 1998 |
Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR.
Topics: Animals; Body Temperature; Brain Chemistry; Chlormethiazole; Excitatory Amino Acid Antagonists; Fever; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Neuroprotective Agents; Paroxetine; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Serotonin | 1998 |
MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Hydroxyindoleacetic Acid; Hypothalamus; Hypothermia; Male; N-Methyl-3,4-methylenedioxyamphetamine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Serotonin Receptor Agonists | 1998 |
The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').
Topics: Animals; Body Temperature; Brain; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Paroxetine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Agents; Tissue Distribution | 1998 |
Memory impairment in abstinent MDMA ("Ecstasy") users.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Illicit Drugs; Male; Memory; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Pattern Recognition, Visual; Regression Analysis; Serotonin; Serotonin Agents; Verbal Learning | 1998 |
N-tert-butyl-alpha-phenylnitrone protects against 3,4-methylenedioxymethamphetamine-induced depletion of serotonin in rats.
Topics: Animals; Body Temperature Regulation; Brain; Brain Stem; Cyclic N-Oxides; Free Radicals; Frontal Lobe; Hippocampus; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Spin Labels | 1999 |
In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism.
Topics: Animals; Biotransformation; Body Temperature; Brain; Cerebral Cortex; Chlormethiazole; Corpus Striatum; Free Radical Scavengers; Gentisates; Hippocampus; Hydroxybenzoates; Hydroxyindoleacetic Acid; Kinetics; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Neuroprotective Agents; Paroxetine; Rats; Salicylic Acid; Serotonin | 1999 |
Cognitive performance in (+/-) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users: a controlled study.
Topics: Adult; Analysis of Variance; Attention; Cognition; Female; Hallucinogens; Humans; Hydroxyindoleacetic Acid; Male; Mental Recall; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Task Performance and Analysis | 1999 |
Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy).
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Catalase; Corpus Striatum; Dopamine; Glutathione Peroxidase; Homovanillic Acid; Hydroxyindoleacetic Acid; Lipid Peroxides; Mice; Mice, Transgenic; N-Methyl-3,4-methylenedioxyamphetamine; Oxidative Stress; Serotonin; Superoxide Dismutase | 1999 |
Effects of antihistamines on 3, 4-methylenedioxymethamphetamine-induced depletion of serotonin in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Body Temperature; Brain Chemistry; Chlorpheniramine; Fever; Histamine H1 Antagonists; Hydroxyindoleacetic Acid; Hydroxyl Radical; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin | 1999 |
Is a single dose of MDMA harmless?
Topics: Animals; Clinical Trials as Topic; Ethics, Medical; Hallucinogens; Humans; Hydroxyindoleacetic Acid; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Serotonin | 1999 |
MDMA and learning: effects of acute and neurotoxic exposure in the rat.
Topics: Animals; Hallucinogens; Hydroxyindoleacetic Acid; Learning; Male; N-Methyl-3,4-methylenedioxyamphetamine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Serotonin; Water Deprivation | 2000 |
Striatal serotonin is depleted in brain of a human MDMA (Ecstasy) user.
Topics: Adult; Brain Mapping; Corpus Striatum; Dopamine; Female; Humans; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Occipital Lobe; Reference Values; Serotonin; Serotonin Agents; Substance-Related Disorders | 2000 |
2-Deoxy-D-glucose prevents and nicotinamide potentiates 3, 4-methylenedioxymethamphetamine-induced serotonin neurotoxicity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine Triphosphate; Animals; Body Temperature; Brain; Carrier Proteins; Corpus Striatum; Dopamine; Drug Synergism; Frontal Lobe; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Hypothermia; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neurotoxins; Niacinamide; Organ Specificity; Paroxetine; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2000 |
Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Brain; Cognition; Dose-Response Relationship, Drug; Evoked Potentials, Auditory, Brain Stem; Hydroxyindoleacetic Acid; Macaca mulatta; Male; Memory Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Neuropsychological Tests; Psychomotor Performance; Serotonin; Time Factors | 2001 |
Long-term impairment of anterograde axonal transport along fiber projections originating in the rostral raphe nuclei after treatment with fenfluramine or methylenedioxymethamphetamine.
Topics: 5,7-Dihydroxytryptamine; Adrenergic Uptake Inhibitors; Animals; Axonal Transport; Axons; Desipramine; Fenfluramine; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Neural Pathways; Neurotoxins; Pargyline; Proline; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Time Factors; Tritium | 2001 |
3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Dopamine; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraventricular; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Perfusion; Rats; Serotonin; Serotonin Agents | 2001 |
A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation.
Topics: Amphetamines; Animals; Body Temperature; Body Temperature Regulation; Brain Chemistry; Hallucinogens; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperazines; Rats; Serotonin; Serotonin Receptor Agonists | 2001 |
Changes in serotonin, dopamine and noradrenaline levels in striatum and nucleus accumbens after repeated administration of the abused drug MDMA in rats.
Topics: Animals; Axons; Dopamine; Drug Administration Schedule; Hallucinogens; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Norepinephrine; Nucleus Accumbens; Prefrontal Cortex; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Retrograde Degeneration; Serotonin; Substance-Related Disorders; Time Factors | 2001 |
Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration.
Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Fenfluramine; GABA Modulators; Hydroxyindoleacetic Acid; Learning; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Reaction Time; Saimiri; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Triazolam | 2002 |
Chronic treatment with supraphysiological levels of corticosterone enhances D-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouse.
Topics: Adrenergic Uptake Inhibitors; Animals; Body Temperature; Corticosterone; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Drug Interactions; Female; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxyindoleacetic Acid; Hypothalamo-Hypophyseal System; Immune System; Mice; Mice, Inbred C57BL; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Neurons; Neurotoxins; Organ Size; Serotonin; Stress, Physiological; Tyrosine 3-Monooxygenase | 2002 |
Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia.
Topics: Animals; Brain; Brain Chemistry; Buthionine Sulfoximine; Drug Therapy, Combination; Fever; Glutathione; Hydroxyindoleacetic Acid; Liver; Male; Maleates; N-Methyl-3,4-methylenedioxyamphetamine; Neurodegenerative Diseases; Paroxetine; Rats; Rats, Inbred Strains; Serotonin; Treatment Outcome | 2002 |
Plasma concentrations of 5-HT, 5-HIAA, norepinephrine, epinephrine and dopamine in ecstasy users.
Topics: Biogenic Monoamines; Dopamine; Epinephrine; Hallucinogens; Humans; Hydroxyindoleacetic Acid; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Psychoses, Substance-Induced; Serotonin; Stress, Physiological; Sympathetic Nervous System | 2002 |
Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Apoptosis; Brain; Dopamine; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxins; Organ Specificity; Rats; Rats, Sprague-Dawley; Serotonin | 2002 |
Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Amphetamines; Animals; Caudate Nucleus; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Methamphetamine; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin | 2002 |
RETRACTED: Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy").
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Axons; Brain; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Hallucinogens; Humans; Hydroxyindoleacetic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Papio; Parkinsonian Disorders; Saimiri; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters; Tremor; Tyrosine 3-Monooxygenase | 2002 |
Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines.
Topics: Amphetamines; Animals; Antimetabolites; Biogenic Monoamines; Body Temperature; Carrier Proteins; Deoxyglucose; Energy Metabolism; Fenfluramine; Glucose; Hydroxyindoleacetic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins | 2002 |
MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities.
Topics: Animals; Autoradiography; Brain; Carrier Proteins; Cerebellar Cortex; Chromatography, High Pressure Liquid; Fenclonine; Hydroxyindoleacetic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Paroxetine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins | 2002 |
Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge.
Topics: Animals; Brain; Cognition; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Reaction Time; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity.
Topics: Animals; Brain; Corticosterone; Exploratory Behavior; Hydroxyindoleacetic Acid; Hypothermia; In Vitro Techniques; Male; Maze Learning; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperazines; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Social Behavior; Substance Withdrawal Syndrome | 2003 |
MDMA ("ecstasy"), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Body Temperature; Corpus Striatum; Dopamine; Dopamine Agents; Drug Interactions; Fever; Hot Temperature; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Wistar; Serotonin; Serotonin Agents; Social Behavior | 2004 |
3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5,7-Dihydroxytryptamine; Animals; Astrocytes; Brain; Brain Chemistry; Carrier Proteins; Down-Regulation; Glial Fibrillary Acidic Protein; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neurons; Neurotoxins; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Up-Regulation | 2004 |
Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Heating; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Neurons; Rats; Serotonin; Serotonin Agents; Time Factors | 2004 |
Preexposure to MDMA ("Ecstasy") delays acquisition but facilitates MDMA-induced reinstatement of amphetamine self-administration behavior in rats.
Topics: Animals; Behavior, Animal; Brain; Dextroamphetamine; Drug Interactions; Extinction, Psychological; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Wistar; Self Administration; Serotonin; Serotonin Agents; Substance-Related Disorders | 2004 |
Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Body Temperature; Brain Chemistry; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Microdialysis; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nucleus Accumbens; Rats; Serotonin; Serotonin Agents; Temperature; Time Factors | 2005 |
Effects of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') and para-methoxyamphetamine on striatal 5-HT when co-administered with moclobemide.
Topics: Amphetamines; Animals; Body Temperature; Drug Interactions; Hallucinogens; Hydroxyindoleacetic Acid; Male; Microdialysis; Moclobemide; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents | 2005 |
MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Brain; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Female; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Random Allocation; Rats; Rats, Long-Evans; Serotonin; Sex Factors; Sexual Maturation; Survival Rate; Time Factors | 2005 |
MDMA ('Ecstasy') and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Brain Chemistry; Central Nervous System Stimulants; Drug Administration Schedule; Drug Combinations; Female; Fever; Hallucinogens; Head Movements; Hydroxyindoleacetic Acid; Interpersonal Relations; Methamphetamine; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Wistar; Serotonin; Swimming; Time Factors | 2005 |
3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity.
Topics: Animals; Blotting, Western; Caspase 1; Chromatography, High Pressure Liquid; Fever; Frontal Lobe; Hallucinogens; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Intraventricular; Interleukin-1; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Peptide Hydrolases; Protein Precursors; Rats; Serotonin | 2005 |
Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Area Under Curve; Behavior, Animal; Body Temperature; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Fever; Hallucinogens; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Seizures; Serotonin | 2006 |
Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease.
Topics: Amphetamines; Animals; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationship, Drug; Electrochemistry; Fluoxetine; Heart Diseases; Hydroxyindoleacetic Acid; Indicators and Reagents; Lung Diseases; Male; Methamphetamine; Microdialysis; Mitogens; Muscle, Smooth, Vascular; N-Methyl-3,4-methylenedioxyamphetamine; Phentermine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stimulation, Chemical | 2006 |
MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature.
Topics: Animals; Body Temperature; Brain; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Serotonin; Temperature; Tryptophan Hydroxylase | 2006 |
Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain.
Topics: Animals; Anti-Bacterial Agents; Brain; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Male; Mice; Microglia; Minocycline; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Serotonin | 2006 |
High-dose MDMA does not result in long-term changes in impulsivity in the rat.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Bias; Brain; Conditioning, Operant; Hallucinogens; Hydroxyindoleacetic Acid; Impulsive Behavior; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Reaction Time; Serotonin; Time Factors | 2006 |
Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamines; Animals; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Hallucinogens; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission; Time Factors | 2006 |
Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats.
Topics: Animals; Anxiety; Behavior, Animal; Body Temperature; Brain; Female; Hallucinogens; Hydroxyindoleacetic Acid; Male; Maze Learning; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin; Sex Characteristics; Sex Factors; Time Factors | 2007 |
The effects of co-administration of 3,4-methylenedioxymethamphetamine ("ecstasy") or para-methoxyamphetamine and moclobemide at elevated ambient temperatures on striatal 5-HT, body temperature and behavior in rats.
Topics: Amphetamines; Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Body Temperature; Chromatography, High Pressure Liquid; Corpus Striatum; Drug Combinations; Hallucinogens; Hydroxyindoleacetic Acid; Male; Moclobemide; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin; Temperature; Time Factors | 2007 |
Potentiation of 3,4-methylenedioxymethamphetamine-induced 5-HT release in the rat substantia nigra by clorgyline, a monoamine oxidase A inhibitor.
Topics: Amphetamines; Animals; Behavior, Animal; Body Temperature; Chromatography, High Pressure Liquid; Clorgyline; Electrochemistry; Electrodes, Implanted; Hydroxyindoleacetic Acid; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Substantia Nigra | 2007 |
The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity.
Topics: Animals; Body Temperature; Brain Chemistry; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Data Interpretation, Statistical; Drug Synergism; Enzyme Inhibitors; Fever; Hallucinogens; Hydroxyindoleacetic Acid; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Nitriles; Rats; Rats, Wistar; Serotonin; Tyrosine | 2008 |
On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.
Topics: Analysis of Variance; Animals; Antimetabolites; Area Under Curve; Body Temperature; Brain; Catechols; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Isoxazoles; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Nitriles; Protein Binding; Rats; Rats, Wistar; Serotonin; Time Factors; Tyrosine | 2008 |
Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex.
Topics: 5-Hydroxytryptophan; Animals; Dose-Response Relationship, Drug; Fluoxetine; Hydrazines; Hydroxyindoleacetic Acid; In Vitro Techniques; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Pargyline; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Time Factors; Tryptophan | 2008 |
Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain.
Topics: Acetylcarnitine; Animals; Body Weight; Brain; Cyclooxygenase 1; DNA, Mitochondrial; Fever; Hallucinogens; Hydroxyindoleacetic Acid; Lipid Peroxidation; Membrane Proteins; Mitochondria; Mitochondrial Diseases; N-Methyl-3,4-methylenedioxyamphetamine; NADH Dehydrogenase; Protein Carbonylation; Rats; Rats, Wistar; Serotonin; Vitamin B Complex | 2009 |
Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat.
Topics: Animals; Blotting, Western; Body Temperature; Brain Chemistry; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Hallucinogens; Hydroxyindoleacetic Acid; Imidazoles; KATP Channels; Male; Microinjections; Mitochondria; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Sildenafil Citrate; Sulfones; Triazines; Vardenafil Dihydrochloride | 2009 |
Mice lacking multidrug resistance protein 1a show altered dopaminergic responses to methylenedioxymethamphetamine (MDMA) in striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred Strains; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin | 2010 |
Atypical development of behavioural sensitization to 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') in adolescent rats and its expression in adulthood: role of the MDMA chirality.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Animals, Newborn; Brain; Chromatography, High Pressure Liquid; Dopamine; Hallucinogens; Hydroxyindoleacetic Acid; Illicit Drugs; Male; Mice; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin; Stereoisomerism | 2010 |
Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats.
Topics: Age Factors; Animals; Binding, Competitive; Body Temperature; Cerebral Cortex; Citalopram; Dose-Response Relationship, Drug; Drug Administration Schedule; Fever; Hippocampus; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxins; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins | 2010 |
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arousal; Body Temperature Regulation; Brain; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Fever; Hallucinogens; Heart Rate; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Serotonin; Serotonin Agents | 2011 |
Adolescent pre-exposure to ethanol or MDMA prolongs the conditioned rewarding effects of MDMA.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Outbred Strains; Cerebral Cortex; Choice Behavior; Conditioning, Psychological; Corpus Striatum; Corticosterone; Dopamine; Drug Administration Schedule; Drug Interactions; Ethanol; Extinction, Psychological; Hippocampus; Hydroxyindoleacetic Acid; Illicit Drugs; Male; Mice; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Reward; Serotonin | 2011 |
Synthesis and neurotoxicity profile of 2,4,5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate.
Topics: Acetylcysteine; Adrenergic Uptake Inhibitors; Animals; Brain; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin | 2011 |
Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Chromatography, High Pressure Liquid; Dopamine; Hydroxyindoleacetic Acid; Locomotion; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Serotonin | 2011 |
Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.
Topics: Animals; Brain; Disease Models, Animal; Female; Fever; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Rats; Rats, Inbred Strains; Serotonin; Serotonin Agents; Sex Characteristics | 2011 |
Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats.
Topics: Adrenergic Uptake Inhibitors; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Body Weight; Brain; Disease Models, Animal; Dronabinol; Drug Administration Schedule; Exploratory Behavior; Fever; Hydroxyindoleacetic Acid; Interpersonal Relations; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Protein Binding; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin | 2011 |
Antidepressant-like effects of 3,4-methylenedioxymethamphetamine in an animal model of depression.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain; Central Nervous System Stimulants; Depressive Disorder; Disease Models, Animal; Hydroxyindoleacetic Acid; Male; Methamphetamine; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin; Swimming | 2011 |
Effect of intermittent exposure to ethanol and MDMA during adolescence on learning and memory in adult mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Corpus Striatum; Dopamine; Ethanol; Hippocampus; Hydroxyindoleacetic Acid; Male; Maze Learning; Memory; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin; Serotonin Agents | 2012 |
Effects of a short-course MDMA binge on dopamine transporter binding and on levels of dopamine and its metabolites in adult male rats.
Topics: Animals; Dopamine; Dopamine Plasma Membrane Transport Proteins; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 2013 |
MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI.
Topics: Animals; Blood Volume; Body Temperature; Cerebral Cortex; Cerebrovascular Circulation; Hallucinogens; Hydroxyindoleacetic Acid; Magnetic Resonance Imaging; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats, Wistar; Serotonin; Serotonin Agents; Spin Labels | 2013 |
Behavioral and neurochemical effects of repeated MDMA administration during late adolescence in the rat.
Topics: Adaptation, Ocular; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Schedule; Exploratory Behavior; Hallucinogens; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 2014 |
Serotonin reuptake transporter deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymethamphetamine, and attenuates depletions in serotonin levels in SERT-KO rats.
Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Gene Knockdown Techniques; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins; Time Factors | 2014 |
5-hydroxytryptamine- and dopamine-releasing effects of ring-substituted amphetamines on rat brain: a comparative study using in vivo microdialysis.
Topics: Amphetamines; Animals; Brain; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dopamine; Extracellular Fluid; Hydroxyindoleacetic Acid; Inhibitory Concentration 50; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Wistar; Serotonin; Time Factors | 2014 |