hydroxyindoleacetic acid has been researched along with 3,4-methylenedioxyamphetamine in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (32.73) | 18.7374 |
| 1990's | 30 (54.55) | 18.2507 |
| 2000's | 5 (9.09) | 29.6817 |
| 2010's | 2 (3.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goromaru, T; Hashimoto, K; Maeda, H | 2 |
| Gibb, JW; Hanson, GR; Johnson, M; Mitros, K; Stone, DM; Zobrist, R | 1 |
| Katz, JL; Martello, AL; Martello, MB; Ricaurte, GA | 1 |
| Culp, S; DeSouza, EB; Lehmann, J; Zaczek, R | 1 |
| McCann, UD; Ricaurte, GA | 1 |
| Katz, JL; Ricaurte, GA; Steele, TD | 1 |
| Gudelsky, GA; Meltzer, HY; Nash, JF | 1 |
| Cho, AK; Hiramatsu, M | 1 |
| Goromaru, T; Hashimoto, K | 2 |
| Gaylor, DW; Slikker, W | 2 |
| Finnegan, KT; Irwin, I; Langston, JW; Ricaurte, GA | 1 |
| Arora, RC; Meltzer, HY; Nash, JF; Schreiber, MA | 1 |
| Cunningham, KA; Paris, JM | 1 |
| Nash, JF; Nichols, DE | 1 |
| Ali, SF; Gough, B; Holson, RR; Slikker, W | 1 |
| Hsu, FL; Yeh, SY | 1 |
| Dornan, WA; Katz, JL; Ricaurte, GA | 1 |
| Chang, AS; Cho, AK; DiStefano, E; Hiramatsu, M | 1 |
| Huang, XM; Johnson, MP; Nichols, DE | 1 |
| Lovenberg, W; Schmidt, CJ; Wu, L | 1 |
| Schmidt, CJ | 1 |
| Battaglia, G; De Souza, EB; Kuhar, MJ; Molliver, ME; O'Hearn, E; Yeh, SY | 1 |
| Gibb, JW; Hanson, GR; Johnson, M | 2 |
| Gibb, JW; Hanson, GR; Stone, DM | 1 |
| Gibb, JW; Hanson, GR; Stahl, DC; Stone, DM | 1 |
| Battaglia, G; De Souza, EB; Yeh, SY | 1 |
| DeLanney, LE; Forno, LS; Irwin, I; Langston, JW; Molliver, ME; Ricaurte, GA; Wilson, MA | 1 |
| Ali, SF; Bailey, JR; Frith, CH; Newport, GD; Scallet, AC; Slikker, W | 1 |
| DeLanney, LE; Irwin, I; Langston, JW; Ricaurte, GA; Wiener, SG | 1 |
| Schmidt, CJ; Taylor, VL | 1 |
| Bush, LG; Gibb, JW; Hanson, GR; Johnson, M; Stone, DM | 1 |
| Battaglia, G; De Souza, EB; Insel, TR; Johannessen, JN; Marra, S | 1 |
| Gibb, JW; Hanson, GR; Johnson, M; Letter, AA; Merchant, K | 1 |
| Kleven, MS; Seiden, LS; Woolverton, WL | 1 |
| Lowy, MT; Meltzer, HY; Nash, JF | 1 |
| Johnson, MP; Nichols, DE | 1 |
| Colado, MI; Green, AR | 1 |
| McCann, UD; Ricaurte, GA; Ridenour, A; Shaham, Y | 1 |
| Du, W; Harvey, JA; Romano, AG | 1 |
| Colado, MI; Green, AR; Williams, JL | 1 |
| Hatzidimitriou, G; Katz, JL; Martello, AL; Ricaurte, GA; Scanzello, CR | 1 |
| Colado, MI; Green, AR; Murray, TK | 1 |
| Hashimoto, K | 1 |
| Bai, F; Lau, SS; Monks, TJ | 1 |
| Connor, TJ; Harkin, A; Kelly, JP; Shanahan, E | 1 |
| Belzung, C; Bodard, S; Chalon, S; Galineau, L; Guilloteau, D; Kodas, E | 1 |
| Harkin, A; Kerans, A; McNamara, R; O'Neill, B | 1 |
| Erives, GV; Lau, SS; Monks, TJ | 1 |
| Irvine, RJ; Jaehne, EJ; Salem, A | 1 |
| Cadet, JL; Huestis, MA; Ladenheim, B; Scheidweiler, KB | 1 |
| Maldonado Adrian, C; McCann, UD; Mueller, M; Ricaurte, GA; Yuan, J | 1 |
1 review(s) available for hydroxyindoleacetic acid and 3,4-methylenedioxyamphetamine
| Article | Year |
|---|---|
Neurotoxic amphetamine analogues: effects in monkeys and implications for humans.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Central Nervous System; Designer Drugs; Haplorhini; Humans; Hydroxyindoleacetic Acid; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxins; Rats; Species Specificity | 1992 |
1 trial(s) available for hydroxyindoleacetic acid and 3,4-methylenedioxyamphetamine
| Article | Year |
|---|---|
Serotonin neurotoxicity after (+/-)3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy"): a controlled study in humans.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Analysis of Variance; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Illicit Drugs; Male; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Pain; Pain Measurement; Personality Tests; Prolactin; Serotonin | 1994 |
53 other study(ies) available for hydroxyindoleacetic acid and 3,4-methylenedioxyamphetamine
| Article | Year |
|---|---|
Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Quipazine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 1992 |
Effect of flunarizine and nimodipine on the decrease in tryptophan hydroxylase activity induced by methamphetamine and 3,4-methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Chromatography, High Pressure Liquid; Diltiazem; Drug Interactions; Enzyme Induction; Flunarizine; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nimodipine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Serotonin; Tryptophan Hydroxylase | 1992 |
Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dopamine; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Norepinephrine; Paroxetine; Piperidines; Saimiri; Serotonin; Serotonin Antagonists | 1992 |
Regional distribution to recovery of 5-HT levels after administration of "atrophins" MDMA and D,L-fenfluramine. Stereospecificity and comparison with 5,7-dihydroxytryptamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Atrophy; Brain; Cerebral Ventricles; Designer Drugs; Dopamine; Fenfluramine; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Organ Specificity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism | 1992 |
Evaluation of the neurotoxicity of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine, PMMA).
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; Hallucinogens; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Rats; Rats, Sprague-Dawley; Serotonin; Structure-Activity Relationship | 1992 |
Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Designer Drugs; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Rats; Rats, Wistar; Serotonin | 1992 |
Effect of 3,4-methylenedioxymethamphetamine on 3,4-dihydroxyphenylalanine accumulation in the striatum and nucleus accumbens.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Ketanserin; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Serotonin; Serotonin Antagonists | 1990 |
Enantiomeric differences in the effects of 3,4-methylenedioxymethamphetamine on extracellular monoamines and metabolites in the striatum of freely-moving rats: an in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Electrochemistry; Fenclonine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism | 1990 |
Reduction of in vivo binding of [3H]paroxetine in mouse brain by 3,4-methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hydroxyindoleacetic Acid; Injections, Intravenous; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists | 1990 |
Risk assessment for neurotoxic effects.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Axons; Designer Drugs; Female; Hippocampus; Hydroxyindoleacetic Acid; Macaca mulatta; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Rats; Rats, Inbred Strains; Risk; Serotonin | 1990 |
Aminergic metabolites in cerebrospinal fluid of humans previously exposed to MDMA: preliminary observations.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Biogenic Amines; Designer Drugs; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Reference Values; Substance-Related Disorders | 1990 |
Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Blood Platelets; Frontal Lobe; Hydroxyindoleacetic Acid; Ketanserin; Kinetics; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Time Factors; Tritium | 1991 |
Reduction of [3H]6-nitroquipazine-labelled 5-hydroxytryptamine uptake sites in rat brain by 3,4-methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Binding Sites; Brain; Drug Interactions; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Quipazine; Radioligand Assay; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tritium | 1990 |
Lack of neurotoxicity after intra-raphe micro-injections of MDMA ("ecstasy").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Immunohistochemistry; Indoles; Male; Microinjections; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin | 1990 |
Microdialysis studies on 3,4-methylenedioxyamphetamine and structurally related analogues.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Corpus Striatum; Dialysis; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Caudate Nucleus; Chromatography, High Pressure Liquid; Dialysis; Dopamine; Electrochemistry; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; In Vitro Techniques; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin | 1991 |
The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Central Nervous System Stimulants; Cerebral Cortex; Deoxyepinephrine; Dopamine; Epinephrine; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nordefrin; Rats; Rats, Inbred Strains; Serotonin | 1991 |
The effects of repeated administration of MDMA on the expression of sexual behavior in the male rat.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Corpus Striatum; Ejaculation; Hippocampus; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Serotonin; Sexual Behavior, Animal | 1991 |
A pharmacokinetic analysis of 3,4-methylenedioxymethamphetamine effects on monoamine concentrations in brain dialysates.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Biological Availability; Brain Chemistry; Corpus Striatum; Dialysis; Dopamine; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Isomerism; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Amphetamine; Animals; Brain; Dopamine; Dopamine Agents; Homovanillic Acid; Hydroxyindoleacetic Acid; Indans; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Serotonin | 1991 |
Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin; Time Factors | 1986 |
Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cerebral Cortex; Fluoxetine; Hydroxyindoleacetic Acid; Kinetics; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Time Factors | 1987 |
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Brain Chemistry; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tritium | 1987 |
Effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE) on central serotonergic and dopaminergic systems of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Corpus Striatum; Dopamine; Frontal Lobe; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Hypothalamus; Male; Rats; Rats, Inbred Strains; Serotonin; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 1987 |
Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Amines; Brain; Corpus Striatum; Hippocampus; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred Strains; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Species Specificity; Time Factors; Tryptophan Hydroxylase | 1987 |
The effects of amphetamine-like designer drugs on monoaminergic systems in rat brain.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Serotonin; Tryptophan Hydroxylase | 1987 |
MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biological Transport, Active; Brain; Dose-Response Relationship, Drug; Guinea Pigs; Hydroxyindoleacetic Acid; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Regeneration; Neurons; Rats; Rats, Inbred Strains; Serotonin; Species Specificity | 1988 |
(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Dose-Response Relationship, Drug; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Macaca fascicularis; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Fibers; Neurons; Raphe Nuclei; Saimiri; Serotonin | 1988 |
Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA).
Topics: 3,4-Methylenedioxyamphetamine; Administration, Oral; Amphetamines; Animals; Brain; Brain Chemistry; Dopamine; Female; Hydroxyindoleacetic Acid; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Species Specificity | 1988 |
5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cebidae; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; N-Methyl-3,4-methylenedioxyamphetamine; Saimiri; Serotonin | 1988 |
Direct central effects of acute methylenedioxymethamphetamine on serotonergic neurons.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cerebral Cortex; Hydroxyindoleacetic Acid; In Vitro Techniques; Infusions, Parenteral; Injections; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Tryptophan Hydroxylase; Tumor Cells, Cultured | 1988 |
Glucocorticoids and 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Adrenalectomy; Amphetamines; Animals; Cerebral Cortex; Corticosterone; Glucocorticoids; Hippocampus; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Rats; Rats, Inbred Strains; Serotonin; Tryptophan Hydroxylase | 1989 |
3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Norepinephrine; Serotonin | 1989 |
Effects of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine isomers on central serotonergic, dopaminergic and nigral neurotensin systems of the rat.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotensin; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Substantia Nigra; Tryptophan Hydroxylase | 1988 |
Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Macaca; Macaca mulatta; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin | 1989 |
Selective reduction of striatal type II glucocorticoid receptors in rats by 3,4-methylenedioxymethamphetamine (MDMA).
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Androstanols; Animals; Corpus Striatum; Corticosterone; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Serotonin | 1989 |
Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Brain Chemistry; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Characterization of acute N-ethyl-3,4-methylenedioxyamphetamine (MDE) action on the central serotonergic system.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analysis of Variance; Animals; Drug Interactions; Fluoxetine; Frontal Lobe; Hippocampus; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase; Pargyline; Rats; Rats, Inbred Strains; Serotonin; Tryptophan Hydroxylase | 1989 |
A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; 4-Butyrolactone; Animals; Brain; Chlormethiazole; Designer Drugs; Dizocilpine Maleate; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Ondansetron; Pentobarbital; Rats; Serotonin | 1994 |
Modeling for risk assessment of neurotoxic effects.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Confidence Intervals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Haplorhini; Hydroxyindoleacetic Acid; Male; Maximum Allowable Concentration; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Reference Values; Risk Factors; Serotonin; Species Specificity | 1994 |
Methylenedioxyamphetamine: a selective effect on cortical content and turnover of 5-HT.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Cell Survival; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Hydroxyindoleacetic Acid; Immunohistochemistry; Male; Neurons; Rabbits; Serotonin | 1994 |
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature Regulation; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Fever; Humans; Hydroxyindoleacetic Acid; Male; Mixed Function Oxygenases; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Phenotype; Proadifen; Quinidine; Rats; Rectum; Serotonin; Serotonin Agents; Sex Factors; Tritium | 1995 |
Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Axons; Brain Chemistry; Hydroxyindoleacetic Acid; Immunohistochemistry; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin | 1993 |
5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Cerebral Cortex; Chlormethiazole; Dizocilpine Maleate; Fenfluramine; Hippocampus; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; p-Chloroamphetamine; Rats; Serotonin | 1993 |
Effects of benzylpiperazine derivatives on the acute effects of 3,4-methylenedioxymethamphetamine in rat brain.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Desipramine; Hydroxyindoleacetic Acid; Imipramine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptosomes | 1993 |
Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Deoxyepinephrine; Glutathione; Hydroxyindoleacetic Acid; Male; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents | 1999 |
Methylenendioxyamphetamine produces serotonin nerve terminal loss and diminished behavioural and neurochemical responses to the antidepressant fluoxetine.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Antidepressive Agents; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Fluoxetine; Hallucinogens; Hydroxyindoleacetic Acid; Male; Paroxetine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin | 2003 |
Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Adrenergic Uptake Inhibitors; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Brain Chemistry; Dopamine; Embryo, Mammalian; Female; Fenfluramine; Hallucinogens; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Membrane Transport Proteins; Microdialysis; Nortropanes; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Sex Factors; Time Factors; Tyramine | 2005 |
Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Area Under Curve; Behavior, Animal; Body Temperature; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Fever; Hallucinogens; Hydroxyindoleacetic Acid; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Seizures; Serotonin | 2006 |
Accumulation of neurotoxic thioether metabolites of 3,4-(+/-)-methylenedioxymethamphetamine in rat brain.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Hydroxyindoleacetic Acid; Male; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Sulfides | 2008 |
The effect of long-term repeated exposure to 3,4-methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Behavior, Animal; Body Temperature Regulation; Cerebral Cortex; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart Rate; Hot Temperature; Humans; Hydroxyindoleacetic Acid; Hyperthermia, Induced; Injections, Intraperitoneal; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Serotonin; Telemetry; Time Factors | 2008 |
Mice lacking multidrug resistance protein 1a show altered dopaminergic responses to methylenedioxymethamphetamine (MDMA) in striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred Strains; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin | 2010 |
Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Deoxyepinephrine; Dextromethorphan; Excitatory Amino Acid Antagonists; Hydroxyindoleacetic Acid; Male; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin; Sulfides | 2011 |