hydroxygenkwanin has been researched along with diosmetin* in 1 studies
1 other study(ies) available for hydroxygenkwanin and diosmetin
| Article | Year |
|---|---|
Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method.
Hydroxygenkwanin (HGK), a natural flavonoid extracted from the buds of Daphne genkwa Sieb.et Zucc. (Thymelaeaceae), possesses a wide range of pharmacological activities, including anti-inflammatory, antibacterial and anticancer. However, the inhibitory effect of HGK on cytochrome P450 (CYP) remains unclear. This study investigated the potential inhibitory effects of HGK on CYP1A2, 2B1/6, 2C9/11, 2D1/6, 2E1 and 3A2/4 enzymes in human and rat liver microsomes (HLMs and RLMs) by the cocktail approach. HGK exhibited no time-dependent inhibition of CYP activities in HLMs and RLMs. Enzyme inhibition kinetics indicated that HGK was not only a competitive inhibitor of human CYP1A2 and 2C9, but also competitively inhibited rat CYP1A2 and 2C11 activities, with K Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Flavonoids; Humans; Isoenzymes; Kinetics; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Risk Assessment | 2022 |