hydroxyflutamide has been researched along with flutamide in 240 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (10.00) | 18.7374 |
| 1990's | 99 (41.25) | 18.2507 |
| 2000's | 72 (30.00) | 29.6817 |
| 2010's | 41 (17.08) | 24.3611 |
| 2020's | 4 (1.67) | 2.80 |
| Authors | Studies |
|---|---|
| Glen, AT; Hughes, LR; Morris, JJ; Taylor, PJ | 1 |
| Ackerman, JH; Bell, MR; Christiansen, RG; D'Ambra, TE; Herrmann, JL; Kullnig, RK; Mallamo, JP; Opalka, CJ; Snyder, BW; Winneker, RC | 1 |
| Affrime, MB; Anjum, S; Cutler, DL; Halstenson, CE; Lambrecht, LJ; Radwanski, E; Swan, SK | 1 |
| Hashimoto, Y; Imai, K; Miyachi, H; Tanatani, A; Wakabayashi, K | 1 |
| Endo, Y; Fijii, S; Goto, T; Ohta, K; Ohta, S; Suzuki, T | 1 |
| Bellavance, E; Luu-The, V; Poirier, D | 1 |
| Badalassi, F; Bertozzi, F; Bradley, SR; Fejzic, A; Gardell, LR; Lewinsky, R; Lund, BW; Olsson, R; Pawlas, J; Piu, F; Schlienger, N; Tabatabaei, A; Thygesen, MB | 1 |
| Endo, Y; Fujii, S; Goto, T; Ohta, K; Ohta, S | 1 |
| Endo, S; Fujii, S; Fujimoto, N; Gouda, H; Hu, D; Iguchi, K; Ikari, A; Irie, K; Kawai, M; Matsukawa, T; Matsunaga, T; Nakayama, T; Oguri, H; Okada, T; Segawa, J; Toyooka, N; Xia, S | 1 |
| Connors, K; Geller, J; Hoffman, RM; Sionit, LR | 1 |
| Huber, GK; Kirschenbaum, A; Levine, AC; Ren, M | 1 |
| Chalmers, D; Kirk, D; Leake, RE; Lloyd, SN | 1 |
| Beato, M; Bock, K; Filmer, A; Hackenberg, R; Hawighorst, T; Schulz, KD; Slater, EP | 1 |
| Cao, C | 1 |
| Breedlove, SM; Fishman, RB | 1 |
| Breedlove, SM; Rand, MN | 2 |
| Bernasconi, D; Cassulo, S; Fazzuoli, L; Giordano, G; Marugo, M; Miglietta, L; Ravera, F | 1 |
| Armstrong, DT; Chandrasekhar, Y | 4 |
| Halushka, PV; Masuda, A; Mathur, R | 1 |
| Mora, G; Muldoon, TG; Steinsapir, J | 1 |
| Cao, CG; Yu, WH | 1 |
| de Launoit, Y; Dufour, M; Labrie, F; Simard, J; Veilleux, R | 1 |
| Asade, RH; Muiño, JP; Prizont, L; Tessler, J | 1 |
| Moon, YS; Yu, FH; Yuen, BH; Yun, YW | 1 |
| Korpacheva, T; Reznikov, A | 1 |
| Reznikov, A | 1 |
| Arbusow, V; Bojar, H; Fittler, F; Klobeck, HG; Schulz, P; Wolf, D | 1 |
| Amaratunga, P; Cartee, RE; Cooney, JC; Frank, D; Haught, J; Humphries, M; Kenter, DC; Leong, P; Rumph, PF; Zampaglioni, N | 1 |
| Dauvois, S; Dumont, M; Haagensen, DE; Labrie, F; Simard, J | 1 |
| Olea, N; Sakabe, K; Sonnenschein, C; Soto, AM | 1 |
| Armstrong, DT; Chandrasekhar, Y; Kennedy, TG | 1 |
| Dauvois, S; Haagensen, DE; Labrie, F; Lévesque, C; Mérand, Y; Simard, J | 1 |
| Begin, DJ; Labrie, F; Luthy, IA | 1 |
| Armstrong, DT; Chandrasekhar, Y; Opavsky, MA; Siuda, A | 1 |
| Baylink, DJ; Farley, JR; Kasperk, CH; Linkhart, TA; Turner, RT; Wergedal, JE | 1 |
| Perentesis, G; Radwanski, E; Symchowicz, S; Zampaglione, N | 1 |
| Gangnerau, MN; Picon, R | 1 |
| Hammond, JM; Spicer, LJ | 1 |
| Dias, JA; Swift, TA | 1 |
| Ayub, M; Levell, MJ | 1 |
| Duleba, AJ; Ho Yuen, B; Kim, KS; Moon, YS | 1 |
| Becker, H; Donn, F; Schmoldt, A; Schulz, M | 1 |
| Baker, D; Labrie, F; Poulin, R | 1 |
| Bélanger, A; Couture, J; Cusan, L; Dupont, A; Giasson, M; Labrie, F | 1 |
| Armstrong, DT; Chandrasekhar, Y; Opavsky, MA; Roe, M | 1 |
| Mauvais-Jarvis, P; Mowszowicz, I; Portois, MC; Santen, RJ | 1 |
| McGinnis, MY; Mirth, MC | 1 |
| Hillier, SG; Purohit, A; Reichert, LE | 1 |
| Handelsman, DJ; Spaliviero, JA; Turtle, JR | 1 |
| Duleba, AJ; Moon, YS; Takahashi, H; Yuen, BH | 1 |
| Azzolin, GC; Saiduddin, S | 1 |
| Messiha, FS | 1 |
| King, RJ; Yates, J | 1 |
| Clark, CR; Merry, BJ; Nowell, NW | 1 |
| Boccuzzi, G; Brignardello, E; Di Monaco, M; Gatto, V; Leonardi, L | 1 |
| Baird, A; Connors, KM; Geller, J; Hoffman, RM; Kohls, M; Sionit, LR | 1 |
| Calabrò, M; Carruba, G; Castagnetta, LA; Farruggio, R; Miceli, MD; Oliveri, G; Pfeffer, U; Sorci, CM | 1 |
| Bravo, AI; Calandra, RS; Capurro, MI; Donaldson, M; Luthy, IA; Mordoh, J; Morvillo, V; Quintans, C | 1 |
| Bartsch, G; Cato, AC; Culig, Z; Hobisch, A; Klocker, H; Peterziel, H; Radmayr, C; Stober, J | 1 |
| Carruba, G; Castagnetta, LA; Comito, L; D'Amico, D; Farruggio, R; Miceli, D; Montesanti, A; Polito, L | 1 |
| Charreau, EH; Dran, G; Lanari, C; Luthy, IA; Molinolo, AA; Montecchia, F; Pasqualini, CD | 1 |
| Kelce, WR; Sar, M; Wilson, EM; Wong, C | 1 |
| Gorczynska, E; Handelsman, DJ | 1 |
| Ajayi, AA; Halushka, PV; Masuda, A; Mathur, R; Matsuda, K; Schrör, K | 1 |
| Bentel, JM; Birrell, SN; Hickey, TE; Horsfall, DJ; Ricciardelli, C; Tilley, WD; Weger, MA | 1 |
| D'Eramo, G; Di Silverio, F; Felli, MP; Frati, L; Gulino, A; Lubrano, C; Maroder, M; Ravenna, L; Sciarra, F; Vacca, A | 1 |
| Biordi, L; Bologna, M; Festuccia, C; Muzi, P; Vicentini, C | 1 |
| Kelley, DB; Robertson, JC; Watson, JT | 1 |
| Deputte, BL; Hempel, M; Johnson, J; Scheffler, G | 1 |
| Boccuzzi, G; Brignardello, E; Di Monaco, M; Gallo, M; Gatto, V; Leonardi, L; Pizzini, A | 1 |
| Dong, Q; Handelsman, DJ; Rintala, H | 1 |
| Dell'Acqua, G; Fattorossi, A; Iacopino, F; Marchetti, P; Pavone-Macaluso, M; Sica, G; van der Kwast, TH | 1 |
| Hsieh, JT; Lin, SH | 1 |
| Nagamani, M; Osuamkpe, C; Yallampalli, C | 1 |
| Govindan, MV; Koutsilieris, M; Pagé, N; Warriar, N | 2 |
| Berrevoets, CA; Mulder, E; Veldscholte, J | 1 |
| Fanger, GR; Henderson, LP; Maue, RA; Tabb, JS; Wilson, EM | 1 |
| Sar, M; Wilson, EM; Wong, CI; Zhou, ZX | 1 |
| Couture, P; Labrie, F; Simard, J; Thériault, C | 1 |
| Halushka, PV; Higashiura, K; Mathur, RS; Zucker, TP | 1 |
| Chang, C; Yeh, S | 1 |
| Kemppainen, JA; Wilson, EM | 1 |
| Beck, S; Hackenberg, R; Hannig, K; Schmidt-Rhode, P; Scholz, A; Schulz, KD | 1 |
| Cooke, GM; Price, CA; Silversides, DW | 1 |
| Kapás, M; Leibinger, J | 1 |
| Burnstein, KL; Cameron, DJ; Dai, JL; Maiorino, CA | 1 |
| Grattan, DR; McCarthy, MM; Rocca, MS; Sagrillo, CA; Selmanoff, M | 1 |
| Chuzel, F; Clark, AM; Saez, JM; Sanchez, P | 1 |
| Lumia, AR; McGinnis, MY; Williams, GW | 1 |
| Caplan, AJ; Fang, Y; Fliss, AE; Robins, DM | 1 |
| Batchelor, KW; Grant, ES; Habib, FK | 1 |
| Babaï, D; Gaido, KW; Gould, JC; Leonard, LS; Lovell, S; McDonnell, DP; Portier, CJ | 1 |
| Jimenez, J; Luizzi, MF; Sonnenschein, C; Soto, AM; Szelei, J | 1 |
| Aichberger, A; Krebs, D; Werner, A | 1 |
| deVere White, RW; French, FS; Gregory, CW; Gumerlock, PH; Hamil, KG; Harris, SE; Mohler, JL; Pretlow, TG; Sar, M; Sharief, Y; Tan, J; Wilson, EM; Zang, DY | 1 |
| Labrie, F; Simard, J; Singh, SM | 1 |
| Chang, C; Miyamoto, H; Yeh, S | 1 |
| Chen, Y; Elbrecht, A; Rutledge, SJ; Schmidt, A; Toney, JH | 1 |
| Bartsch, G; Cronauer, MV; Culig, Z; Hittmair, A; Hobisch, A; Klocker, H; Radmayr, C; Zhang, J | 1 |
| Gurpide, E; Markiewicz, L | 1 |
| Galosy, S; Gudmundsson, GO; Newcomer, B; Sridaran, R; Talamantes, F; Thordarson, G | 1 |
| Barañao, JL; Bley, MA; Saragüeta, PE | 1 |
| Boschelli, F; Caplan, AJ; Fang, Y; Fliss, AE | 1 |
| Belsham, DD; Brown, TJ; Duc, VL; Evangelou, A; Roy, D | 1 |
| Danielpour, D; Lucia, MS; Roberts, AB; Sporn, MB; Stewart, LV | 1 |
| Chang, C; Miyamoto, H; Wilding, G; Yeh, S | 1 |
| Gaido, KW; Maness, SC; McDonnell, DP | 1 |
| Hicok, KC; Hofbauer, LC; Khosla, S | 1 |
| Chang, C; Lardy, H; Messing, E; Miyamoto, H; Yeh, S | 1 |
| Darne, C; Jean, C; Veyssiere, G | 1 |
| Balk, SP; Bubley, GJ; Fenton, MA; Fertig, AM; Kolvenbag, G; Shuster, TD; Taplin, ME | 1 |
| Cavazzini, P; degli Uberti, EC; del Senno, L; Fallo, F; Rossi, R; Valentini, A; Zatelli, MC | 1 |
| Fournier, A; Labrie, C; Lapointe, J; Richard, V | 1 |
| Judd, J; Kremer, M; Oursler, MJ; Pascoe, D; Pederson, L; Riggs, BL; Spelsberg, TC | 1 |
| Chang, C; Kang, HY; Lin, HK; Lin, MF; Thin, TH; Yeh, S | 1 |
| Budman, DR; Kreis, W; Liu, XM; Wang, LG | 1 |
| Li, D; Xu, CJ | 2 |
| Hackenberg, R; Loos, S; Schulz, KD | 1 |
| Hofbauer, LC; Khosla, S; Ten, RM | 1 |
| Fan, Z; Mendelsohn, J; Ye, D | 1 |
| Caplan, AJ; Cheetham, ME; Fliss, AE; Melville, MW; Rao, J | 1 |
| Celermajer, DS; Death, AK; Handelsman, DJ; Jessup, W; McCrohon, JA; Nakhla, S; Stanley, KK | 1 |
| Bardin, CW; Catterall, JF; Crozat, A; Kumar, N; Li, F; Sundaram, K | 1 |
| Brown, TJ; Evangelou, A; Jindal, SK; Letarte, M | 1 |
| Chang, C; Chang, HC; Fujimoto, N; Hu, YC; Huang, KE; Kang, HY; Lin, HK; Miyamoto, H; Mizokami, A; Nishimura, K; Rahman, M; Ting, HJ; Yeh, S | 1 |
| Lumbroso, S; Moras, D; Nicolas, JC; Poujol, N; Sultan, C; Tahiri, B; Wurtz, JM | 1 |
| Chang, C; Wang, C; Young, WJ | 1 |
| Jones, GR; Lyng, FM; Rommerts, FF | 1 |
| Danielsen, M; Harris, VK; List, HJ; Martinez, E; Riegel, AT; Smith, CL | 1 |
| Damien, E; Lanyon, LE; Price, JS | 1 |
| Bentel, JM; Buchanan, G; Greenberg, NM; Han, G; Harris, JM; Horsfall, DJ; Marshall, VR; Matusik, RJ; Moore, N; Nahm, HS; Tilley, WD; Yang, M | 1 |
| Appa Rao, KB; Gui, Y; Lessey, BA; Lovely, LP | 1 |
| Chen, Q; Chihara, K; Kaji, H; Sugimoto, T | 1 |
| Atkin, SL; Bilko, D; Newton, CJ; Pappa, S | 1 |
| Bishop, TC; Dalton, JT; Kirkovsky, L; Marhefka, CA; Miller, DD; Moore, BM; Mukherjee, A | 1 |
| Goto, K; Morinaga, H; Nawata, H; Nomura, M; Okabe, T; Takayanagi, R; Tomura, A; Yanase, T | 1 |
| Daftsios, AC; Niopas, I | 1 |
| Andriani, F; Denner, L; Fang, B; Kagawa, S; Kasper, S; Li, X; Marcelli, M; Matusik, RJ; McPhaul, MJ; Nan, B; Weigel, NL; Yu, J | 1 |
| Bobseine, KL; Britt, BH; Cardon, MC; Gray, LE; Hartig, PC; Lambright, CR; Wilson, VS | 1 |
| Baniahmad, A; Cato, AC; Dotzlaw, H; Iñiguez Lluhí, JA; Mink, S; Moehren, U | 1 |
| Deng, QL; Li, D; Ma, XC; Wang, HX | 1 |
| Furutani, T; Hashimoto, T; Kato, S; Koutoku, H; Kudoh, M; Shikama, H; Shimizu, Y; Tanimoto, K; Watanabe, T | 1 |
| Bongers, G; Buttini, M; LeFevour, A; Mucke, L; Raber, J | 1 |
| Bartsch, G; Culig, Z; Godoy-Tundidor, S; Hobisch, A; Pfeil, K | 1 |
| Jänne, OA; Karvonen, U; Palvimo, JJ | 1 |
| Bonmassar, E; Faraoni, I; Missale, C; Rizzetti, MC; Sigala, S; Spano, P; Tognazzi, N | 1 |
| Chan, FL; Chang, C; Huang, J; Lee, YF; Lin, WJ; Messing, EM; Wilding, G | 1 |
| Lumia, AR; McGinnis, MY; Montana, RC | 1 |
| Li, D; Liu, X; Wang, HX; Xu, CJ | 1 |
| Lou, YR; Nazarova, N; Pennanen, P; Qiao, S; Tuohimaa, P | 1 |
| Aozasa, K; Chang, C; Chang, HC; Harada, Y; Kang, HY; Miyamoto, H; Nishimura, K; Nonomura, N; Okuyama, A; Shin, M; Ting, HJ; Tokizane, T; Yeh, S | 1 |
| Toombs, AR; Wiren, KM; Zhang, XW | 1 |
| Armstrong, DT; Gilchrist, RB; Hickey, TE; Marrocco, DL; Norman, RJ | 1 |
| Callewaert, L; Claessens, F; Haelens, A; Verrijdt, G | 1 |
| Fujisawa, Y; Harano, M; Hida, T; Kano, M | 1 |
| Ishizuka, M; Kawada, M; Minamiguchi, K; Ohba, S; Takamoto, K | 1 |
| Stöckle, M; Tahmatzopoulos, A; Unteregger, G; Wullich, B; Zwergel, T; Zwergel, U | 1 |
| Lemaire, G; Mauvais, P; Michel, S; Rahmani, R; Terouanne, B | 1 |
| Chang, C; Hsu, CL; Hu, YC; Huang, J; Kim, E; Li, P; Lin, HK; Ni, J; Sampson, ER; Ting, HJ; Wang, L; Yeh, S; Yeh, SD | 1 |
| Harding, SM; McGinnis, MY | 1 |
| Chung, K; Dalton, JT; Gao, W; Kearbey, JD; Miller, DD; Nair, VA; Parlow, AF | 1 |
| Derk, RC; Murono, EP | 1 |
| Bevan, CL; Cato, AC; Gamble, SC; Hanrahan, S; Hurst, HC; Totty, N; Waxman, J; Whitaker, HC | 1 |
| Lou, YR; Nazarova, N; Talonpoika, R; Tuohimaa, P | 1 |
| Andersen, ME; Bogdanffy, MS; Bus, JS; Cohen, SD; Conolly, RB; David, RM; Doerrer, NG; Dorman, DC; Gaylor, DW; Hattis, D; Rogers, JM; Setzer, RW; Slikker, W; Swenberg, JA; Wallace, K | 1 |
| Anido, M; Bacallao, K; Clementi, M; Johnson, C; Maliqueo, MA; Quezada, S; Vega, M | 1 |
| Ajayi, AA; Halushka, PV | 1 |
| Amato, F; Armstrong, DT; Gilchrist, RB; Hickey, TE; Marrocco, DL; Norman, RJ; Ritter, LJ | 1 |
| Borngraeber, S; Carbonell, X; Chapman, MS; Diamond, MI; Guerbadot, M; Ma, AA; Miner, JN; Schaufele, F | 1 |
| Bechor, Y; Birman, A; Chisin, R; Even-Sapir, E; Fadeeva, L; Golan, E; Gozin, M; Gutman, M; Icar, A; Jacobson, O; Leibovitch, I; Marom, H; Mishani, E; Novak, N | 1 |
| Farla, P; Hersmus, R; Houtsmuller, AB; Trapman, J | 1 |
| Asim, M; Baniahmad, A; Dotzlaw, H; Papaioannou, M; Reeb, C | 1 |
| Hajszan, T; Johansen, JA; Jordan, CL; Leranth, C; MacLusky, NJ | 1 |
| Bondesson, U; Hedeland, M; Jönsson, M; Lennernäs, B; Lennernäs, H; Norlin, M; Tevell, A | 1 |
| Choi, KC; Jeung, EB; Ji, YK; Lee, GS | 1 |
| Carlson, KE; Chisin, R; Elgavish, S; Even-Sapir, E; Gozin, M; Gutman, M; Jacobson, O; Katzenellenbogen, JA; Laky, D; Leibovitc, I; Mishani, E | 1 |
| Jenks, C; Katzenellenbogen, JA; Parent, EE; Sharp, T; Welch, MJ | 1 |
| Gutierrez, CG; Rangel, PL; Rodríguez, A | 1 |
| Chang, CY; Elbi, C; Hager, GL; Hendarwanto, A; Klokk, TI; Kurys, P; Nagaich, AK; Saatcioglu, F; Slagsvold, T | 1 |
| De Rosier, T; Eliason, HC; Ervin, KM; Gowda, K; Kupcho, KR; Marks, BD; Ozers, MS; Qadir, N; Riddle, SM; Shekhani, MS | 1 |
| Fuse, H; Hiyama, T; Ito, T; Kato, S; Kimura, K; Korenaga, S; Sakari, M | 1 |
| Hara, S; Hyochi, N; Isaacs, JT; Ishioka, J; Kageyama, Y; Kihara, K; Singh, P; Urushibara, M | 1 |
| Akahoshi, T; Ariga, H; Hayashi, H; Itoh, Y; Miyazawa, K; Okamoto, T; Onozaki, K; Otsuka, T; Takii, T; Waguri-Nagaya, Y; Xu, J | 1 |
| Meyer, R; Obendorf, M; Wolf, SS | 1 |
| Aso, T; Harada, T; Ishikawa, T; Kubota, T | 1 |
| Ellis, E; Kostrubsky, SE; Mutlib, AE; Nelson, SD; Strom, SC | 1 |
| Bao, BY; Cai, Y; Chang, C; Hsu, CL; Huang, J; Lee, YF; Li, G; Liu, S | 1 |
| Guarino, G; Spampinato, S | 1 |
| Baniahmad, A; Eskelinen, H; Lehtovuori, PT; Nyrönen, TH; Roell, D; Söderholm, AA; Viiliäinen, J | 1 |
| Lenie, S; Smitz, J | 1 |
| Hara, S; Isaacs, JT; Ishioka, J; Kageyama, Y; Nishikawa, K; Tomura, A | 1 |
| Dubbink, HJ; Hersmus, R; Jenster, G; Lusher, SJ; Molier, M; Trapman, J; van de Wijngaart, DJ | 1 |
| Chippari, S; Crabtree, JS; Harris, HA; Kenney, T; Kilbourne, EJ; McNally, C; Nagpal, S; Peano, BJ; Thompson, CC; Wang, W; Winneker, RC | 1 |
| Walker, WH | 1 |
| Qian, ZY; Wu, D; Xiang, Y; Zheng, H | 1 |
| Amadio, J; Murphy, CD | 1 |
| Itoh, K; Kanayama, H; Kawabata, R; Oie, S; Oka, T; Takahashi, M | 1 |
| Jensen, GE; Niemela, JR; Nikolov, NG; Ringsted, T; Wedebye, EB | 1 |
| Anonuevo, A; Bingham, B; Gray, M; Innala, L; Myung, C; Viau, V | 1 |
| Bao, TY; Fu, Q; Gao, JY; Gao, XP; Lei, YH; Li, JQ; Li, YM; Liu, F; Qiu, JX; Shao, C; Shi, CH; Wang, JY; Wang, Y; Xue, W; Yang, ZY; Yuan, JL; Zhang, W; Zhang, YT | 1 |
| Dits, NF; Erkens-Schulze, S; Jenster, G; Marques, RB; van Ijcken, WF; van Weerden, WM | 1 |
| Andrieu, T; Baker, ME; Bertolini, R; Frey, BM; Frey, FJ; Nichols, SE; Setoud, R | 1 |
| Bilinska, B; Gaczarzewicz, D; Koziorowski, M; Lydka, M; Piasecka, M | 1 |
| Chang, C; Hsu, JW; Izumi, K; Miyamoto, H; Zheng, Y | 1 |
| Duda, M; Durlej, M; Knapczyk-Stwora, K; Knet, M; Slomczynska, M; Tabarowski, Z | 1 |
| Brochot, C; Bunescu, A; Choucha Snouber, L; Dumas, ME; Elena-Herrmann, B; Leclerc, E; Legallais, C; Naudot, M | 1 |
| Duda, M; Durlej-Grzesiak, M; Knapczyk-Stwora, K; Knet, M; Slomczynska, M; Tabarowski, Z; Wolna, A | 1 |
| Duda, M; Durlej-Grzesiak, M; Slomczynska, M; Tabarowski, Z | 1 |
| Imasaka, T; Li, X; Miyake, R; Uchimura, T | 1 |
| Chang, C; Huang, CK; Kang, HY; Lee, SO; Luo, J; Tsai, MY | 1 |
| Inouye, Y; Kanno, Y; Kato, K; Kusakabe, T; Ota, R; Someya, K | 1 |
| Duda, M; Grzesiak, M; Knapczyk-Stwora, K; Knet, M; Michna, A; Slomczynska, M; Tabarowski, Z | 1 |
| Culig, Z | 1 |
| Axén, N; Isotalo, T; Lennernäs, B; Lennernäs, H; Malmsten, LÅ; Sjögren, E; Taari, K; Tammela, TL | 1 |
| Bilinska, B; Jendraszak, M; Kotula-Balak, M; Kotwicka, M; Skibinska, I; Zarzycka, M | 1 |
| Begum, S; Bevan, CL; Brooke, GN; Bryan, RA; Dart, DA; Fioretti, FM; Gamble, SC; Hough, MA; Odontiadis, M; Powell, SM; Wait, R; Waxman, J | 1 |
| Makita, M; Miyano, T | 1 |
| Chang, C; Han, R; Li, Y; Messing, E; Niu, Y; Shang, Z; Shyr, CR; Tian, J; Yeh, S; Zhang, M | 1 |
| Bilinska, B; Chojnacka, K; Gorowska, E; Hejmej, A; Klimek, M; Kotula-Balak, M; Mruk, DD; Zarzycka, M | 1 |
| Awrey, S; Azad, AA; Cherkasov, A; Chi, KN; Collins, CC; Gleave, ME; Lallous, N; LeBihan, S; Leblanc, E; Murillo, J; Rennie, PS; Singh, K; Tse, R; Volik, SV; Wyatt, AW | 1 |
| Hara, N; Ishizaki, F; Nishiyama, T; Takeda, K; Tasaki, M; Tomita, Y | 1 |
| El-Shishtawy, KA; Ide, H; Kashiwagi, E; Kawahara, T; Li, Y; Miyamoto, H; Reis, LO; Zheng, Y | 1 |
| Alfirevic, A; Ball, AL; Chadwick, AE; Kamalian, L; Lyon, JJ | 1 |
| Bilinska, B; Galas, J; Kaminska, A; Kotula-Balak, M; Pardyak, L; Ptak, A | 1 |
| Bilińska, B; Dulińska-Litewka, J; Górowska-Wójtowicz, E; Hejmej, A; Kamińska, A; Kotula-Balak, M; Laidler, P; Pardyak, L | 1 |
| Buzon-Cuevas, A; Mendoza, FJ; Perez-Ecija, A; Serrano-Rodriguez, JM | 1 |
| Ahlström, H; Axén, N; Gölander, CG; Häggman, M; Isotalo, T; Ladjevardi, S; Lennernäs, B; Lennernäs, H; Taari, K; Tammela, TL; Tolf, A; von Below, C; Wassberg, C; Weis, J | 1 |
| Li, JZ; Liu, HL; Song, TQ; Zhong, HY | 1 |
| Grzesiak, M; Herian, M; Luck, MR | 1 |
| Chuang, KH; Ide, H; Inoue, S; Jiang, G; Miyamoto, H; Mizushima, T; Oya, M | 1 |
| Azhagiya Singam, ER; Durkin, KA; La Merrill, MA; Smith, MT; Tachachartvanich, P | 1 |
| Fujii, S; Ishigami-Yuasa, M; Kagechika, H; Kawachi, E; Kinoshita, M; Koga, H; Mori, S; Negishi, M; Tanatani, A | 1 |
| Alfirevic, A; Ball, AL; Bloch, KM; Chadwick, AE; Gregory, R; Kenny, J; Liu, X; Lyon, JJ; Rainbow, L | 1 |
| Alfirevic, A; Ball, AL; Chadwick, AE; Jolly, CE; Lennon, MG; Lyon, JJ | 1 |
2 review(s) available for hydroxyflutamide and flutamide
| Article | Year |
|---|---|
Dose-dependent transitions in mechanisms of toxicity: case studies.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Androgen Antagonists; Animals; Butadienes; Dichloroethylenes; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Epoxy Compounds; Ethylene Glycol; Flutamide; Formaldehyde; Humans; Manganese; Manganese Poisoning; Methylene Chloride; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors; Progesterone; Vinyl Compounds; Zinc | 2004 |
Targeting the androgen receptor in prostate cancer.
Topics: Androgen Antagonists; Anilides; Antibodies, Neutralizing; Anticarcinogenic Agents; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Curcumin; Flutamide; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Male; Molecular Targeted Therapy; Nitriles; Oligonucleotides, Antisense; Phenylthiohydantoin; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Steroid 17-alpha-Hydroxylase; Tosyl Compounds | 2014 |
5 trial(s) available for hydroxyflutamide and flutamide
| Article | Year |
|---|---|
Steady-state hydroxyflutamide plasma levels after the administration of two dosage forms of flutamide.
Topics: Adult; Analysis of Variance; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Female; Flutamide; Humans; In Vitro Techniques; Male; Middle Aged; Nausea; Patient Compliance; Time Factors | 1991 |
[Examination of the change in plasma concentration of OH-flutamide in low-dose flutamide (250 mg/day) monotherapy for prostate cancer patients].
Topics: Aged; Alanine Transaminase; Androgen Antagonists; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Flutamide; Humans; Liver Function Tests; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Reference Values | 2004 |
Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.
Topics: Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Biotransformation; Chromatography, Liquid; Dogs; Flutamide; Glucuronidase; Humans; In Vitro Techniques; Male; Microsomes, Liver; Prostate; Prostatic Neoplasms; Rats; Spectrometry, Mass, Electrospray Ionization; Swine | 2006 |
Pharmacokinetics of an injectable modified-release 2-hydroxyflutamide formulation in the human prostate gland using a semiphysiologically based biopharmaceutical model.
Topics: Area Under Curve; Chemistry, Pharmaceutical; Delayed-Action Preparations; Flutamide; Half-Life; Humans; Male; Models, Biological; Prostate; Prostatic Neoplasms | 2014 |
An Intraprostatic Modified Release Formulation of Antiandrogen 2-Hydroxyflutamide for Localized Prostate Cancer.
Topics: Aged; Androgen Antagonists; Delayed-Action Preparations; Flutamide; Humans; Injections, Intralesional; Male; Middle Aged; Prostatic Neoplasms | 2017 |
233 other study(ies) available for hydroxyflutamide and flutamide
| Article | Year |
|---|---|
Non-steroidal antiandrogens. Design of novel compounds based on an infrared study of the dominant conformation and hydrogen-bonding properties of a series of anilide antiandrogens.
Topics: Androgen Antagonists; Anilides; Animals; Drug Design; Hydrogen Bonding; Indicators and Reagents; Molecular Conformation; Molecular Structure; Rats; Receptors, Androgen; Spectrophotometry, Infrared; Structure-Activity Relationship | 1991 |
Antiandrogenic steroidal sulfonylpyrazoles.
Topics: Androgen Antagonists; Animals; Male; Molecular Structure; Orchiectomy; Organ Size; Pregnanes; Prostate; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Androgen; Structure-Activity Relationship; Testosterone; X-Ray Diffraction | 1990 |
Pharmacokinetics of flutamide in patients with renal insufficiency.
Topics: Androgen Antagonists; Area Under Curve; Flutamide; Half-Life; Humans; Male; Middle Aged; Renal Dialysis; Renal Insufficiency | 1999 |
4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Cell Line, Tumor; Humans; Male; Mutation; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Binding; Pyrroles; Receptors, Androgen | 2008 |
Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Animals; Binding, Competitive; Boranes; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Evaluation, Preclinical; Flutamide; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Molecular Structure; NIH 3T3 Cells; Nitriles; Pyridines; Receptors, Androgen; Stereoisomerism; Structure-Activity Relationship; Tosyl Compounds; Transfection | 2008 |
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
Topics: 17-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstanes; Biocatalysis; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Humans; Inhibitory Concentration 50; Oxidation-Reduction; Substrate Specificity | 2009 |
Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.
Topics: Administration, Oral; Androgen Receptor Antagonists; Androgens; Animals; Azabicyclo Compounds; Dogs; Drug Design; Humans; Ligands; Male; Mice; Microsomes, Liver; Mutation; NIH 3T3 Cells; Orchiectomy; Prostatic Neoplasms; Rats; Receptors, Androgen; Structure-Activity Relationship; Substrate Specificity; Testosterone Propionate | 2009 |
Design and synthesis of androgen receptor full antagonists bearing a p-carborane cage: promising ligands for anti-androgen withdrawal syndrome.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Antineoplastic Agents, Hormonal; Boranes; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Androgen | 2010 |
Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer.
Topics: Aldo-Keto Reductase Family 1 Member C3; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Design; Enzyme Inhibitors; G1 Phase Cell Cycle Checkpoints; Humans; Male; Mice, Inbred BALB C; PC-3 Cells; Prostatic Neoplasms, Castration-Resistant; Xenograft Model Antitumor Assays | 2020 |
Measurement of androgen sensitivity in the human prostate in in vitro three-dimensional histoculture.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Dihydrotestosterone; Flutamide; Histological Techniques; Humans; Male; Prostate; Prostatic Hyperplasia; Receptors, Androgen; Thymidine | 1992 |
The effect of androgen, estrogen, and growth factors on the proliferation of cultured fibroblasts derived from human fetal and adult prostates.
Topics: Cell Division; Cells, Cultured; Dihydrotestosterone; Epidermal Growth Factor; Estradiol; Female; Fetus; Fibroblasts; Flutamide; Genes, fos; Growth Substances; Humans; Immunohistochemistry; Male; Pregnancy; Prostate; Prostatic Hyperplasia; RNA, Messenger | 1992 |
Local hyperthermia for prostatic disease: in vitro studies on human prostatic cancer cell lines.
Topics: Cell Division; Cell Survival; Dihydrotestosterone; DNA, Neoplasm; Flutamide; Humans; Hyperthermia, Induced; Male; Prostatic Neoplasms; Tumor Cells, Cultured | 1992 |
Regulation of androgen receptor mRNA and protein level by steroid hormones in human mammary cancer cells.
Topics: Blotting, Northern; Breast Neoplasms; Cyproterone; Dihydrotestosterone; Estradiol; Flutamide; Gene Expression Regulation, Neoplastic; Hormones; Humans; Immunohistochemistry; Progesterone Congeners; Radioligand Assay; Receptors, Androgen; RNA, Messenger; Steroids; Tumor Cells, Cultured | 1992 |
[Androgen receptors in muscles mediate the trophic effect of testosterone on axotomized neurons].
Topics: Animals; Axons; Facial Nerve; Female; Flutamide; Hypoglossal Nerve; Motor Neurons; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Testosterone | 1992 |
Local perineal implants of anti-androgen block masculinization of the spinal nucleus of the bulbocavernosus.
Topics: Animals; Embryonic and Fetal Development; Female; Flutamide; Injections; Motor Neurons; Muscles; Perineum; Rats; Sex Differentiation; Spinal Cord; Testosterone | 1992 |
Androgen locally regulates rat bulbocavernosus and levator ani size.
Topics: Animals; Cholera Toxin; Drug Implants; Flutamide; Horseradish Peroxidase; Male; Muscle Development; Muscles; Orchiectomy; Organ Size; Penis; Rats; Rats, Inbred Strains; Testosterone | 1992 |
Effects of dihydrotestosterone and hydroxyflutamide on androgen receptors in cultured human breast cancer cells (EVSA-T).
Topics: Androgen Antagonists; Breast Neoplasms; Cell Division; Dihydrotestosterone; Flutamide; Humans; Receptors, Androgen; Tumor Cells, Cultured | 1992 |
Effects of the antiandrogen hydroxyflutamide on progesterone secretion by preovulatory rat follicles in vivo and in vitro.
Topics: Androgen Receptor Antagonists; Animals; Chorionic Gonadotropin; Culture Techniques; Estrus; Feedback; Female; Flutamide; Luteinizing Hormone; Ovarian Follicle; Ovulation; Progesterone; Radioimmunoassay; Rats; Rats, Inbred Strains | 1991 |
Testosterone increases thromboxane A2 receptors in cultured rat aortic smooth muscle cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Calcium; Cells, Cultured; Estradiol; Flutamide; Male; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Radioligand Assay; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Testosterone; Thromboxane A2 | 1991 |
Regulation of uterine progesterone receptors by the nonsteroidal anti-androgen hydroxyflutamide.
Topics: Androgen Antagonists; Animals; Dose-Response Relationship, Drug; Estradiol; Female; Flutamide; Organ Size; Promegestone; Rats; Rats, Inbred Strains; Receptors, Progesterone; Tritium; Uterus | 1991 |
Effects of steroidal and non-steroidal antiandrogens on the androgen binding properties of the rat ventral prostate androgen receptor.
Topics: Androgen Antagonists; Animals; Cycloheximide; Flutamide; Imidazoles; Imidazolidines; Kinetics; Male; Prostate; Rats; Receptors, Androgen | 1991 |
Muscle as the primary site for testosterone to promote survival of axotomized motoneurons.
Topics: Anesthesia; Animals; Axons; Facial Nerve; Female; Flutamide; Hypoglossal Nerve; Motor Neurons; Muscles; Rats; Rats, Inbred Strains; Testosterone | 1991 |
Characteristics of the biphasic action of androgens and of the potent antiproliferative effects of the new pure antiestrogen EM-139 on cell cycle kinetic parameters in LNCaP human prostatic cancer cells.
Topics: Androgens; Androstane-3,17-diol; Binding, Competitive; Cell Cycle; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Antagonism; Estradiol; Estrogen Antagonists; Estrone; Flow Cytometry; Flutamide; Humans; In Vitro Techniques; Male; Metribolone; Piperidines; Prostatic Neoplasms; Raloxifene Hydrochloride; Tamoxifen; Testosterone; Time Factors; Tumor Cells, Cultured | 1991 |
Effects of hydroxyflutamide on rats treated with a superovulatory dose of pregnant mare serum gonadotropin.
Topics: Androgens; Animals; Chromatography, High Pressure Liquid; Estradiol; Female; Flutamide; Gonadotropins, Equine; Oocytes; Organ Culture Techniques; Ovary; Ovulation; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains | 1991 |
Nonsteroid antiandrogen inhibiting effect on testosterone metabolism in rat prostate and liver.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Dihydrotestosterone; Flutamide; Liver; Male; Orchiectomy; Prostate; Rats; Rats, Inbred Strains; Testosterone | 1990 |
Feedback control of gonadotropin secretion in mammalian and human males: effects of gonadotropin receptor blockers.
Topics: Anilides; Animals; Dogs; Feedback; Flutamide; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Guinea Pigs; Humans; Luteinizing Hormone; Male; Rabbits; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Gonadotropin; Succinate Dehydrogenase; Testosterone | 1990 |
The synthetic androgen mibolerone induces transient suppression of the transformed phenotype in an androgen responsive human prostatic carcinoma cell line.
Topics: Androgen Antagonists; Androgens; Cell Division; Cell Transformation, Neoplastic; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Humans; Male; Nandrolone; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Tumor Cells, Cultured | 1990 |
Evaluation of drug-induced prostatic involution in dogs by transabdominal B-mode ultrasonography.
Topics: Animals; Dogs; Flutamide; Male; Prostate; Ultrasonography | 1990 |
Opposite effects of estrogen and the progestin R5020 on cell proliferation and GCDFP-15 expression in ZR-75-1 human breast cancer cells.
Topics: Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Division; Drug Interactions; Estradiol; Flutamide; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Membrane Transport Proteins; Mifepristone; Neoplasm Proteins; Promegestone; Tumor Cells, Cultured | 1990 |
The proliferative effect of "anti-androgens" on the androgen-sensitive human prostate tumor cell line LNCaP.
Topics: Androgens; Antibodies; Cell Division; Dihydrotestosterone; Estradiol; Flutamide; Humans; Male; Nandrolone; Prostatic Neoplasms; Receptors, Androgen; Testosterone Congeners; Tumor Cells, Cultured | 1990 |
Implantation delay and anti-deciduogenic activity in the rat by the anti-androgen, hydroxyflutamide.
Topics: Anilides; Animals; Decidua; Embryo Implantation; Embryo Implantation, Delayed; Female; Flutamide; Pregnancy; Rats; Rats, Inbred Strains | 1990 |
Regulation of progesterone-binding breast cyst protein GCDFP-24 secretion by estrogens and androgens in human breast cancer cells: a new marker of steroid action in breast cancer.
Topics: Androgens; Apolipoproteins; Apolipoproteins D; Binding, Competitive; Biomarkers, Tumor; Breast Neoplasms; Carrier Proteins; Cell Division; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Estrogens; Female; Flutamide; Glycoproteins; Humans; Kinetics; Membrane Transport Proteins; Neoplasm Proteins; Progesterone; Tumor Cells, Cultured | 1990 |
Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture.
Topics: Androgens; Animals; Cell Division; Chlormadinone Acetate; Dihydrotestosterone; Flutamide; Male; Mammary Neoplasms, Experimental; Medroxyprogesterone; Medroxyprogesterone Acetate; Megestrol; Mice; Progestins; Spironolactone; Tumor Cells, Cultured | 1988 |
Bimodal effects of luteinizing hormone and role of androgens in modifying superovulatory responses of rats to infusion with purified porcine follicle-stimulating hormone.
Topics: Androgens; Animals; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Female; Flutamide; Follicle Stimulating Hormone; Luteinizing Hormone; Ovary; Ovulation; Rats; Rats, Inbred Strains; Superovulation; Time Factors | 1989 |
Androgens directly stimulate proliferation of bone cells in vitro.
Topics: Alkaline Phosphatase; Androgens; Animals; Binding, Competitive; Cell Count; Cell Differentiation; Cell Division; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; DNA; Dose-Response Relationship, Drug; Fluoxymesterone; Flutamide; Humans; Methenolone; Mice; Osteoblasts; Testosterone; Tumor Cells, Cultured | 1989 |
Single and multiple dose pharmacokinetic evaluation of flutamide in normal geriatric volunteers.
Topics: Administration, Oral; Aged; Anilides; Biological Availability; Chromatography, Gas; Flutamide; Half-Life; Humans; Male | 1989 |
Onset of steroidogenesis and differentiation of functional LH receptors in rat fetal testicular cultures.
Topics: Aminoglutethimide; Animals; Binding, Competitive; Bucladesine; Cyproterone; Cyproterone Acetate; Dehydroepiandrosterone; Flutamide; Gestational Age; Luteinizing Hormone; Male; Organ Culture Techniques; Progesterone; Rats; Rats, Inbred Strains; Receptors, LH; Testis; Testosterone | 1987 |
Comparative effects of androgens and catecholestrogens on progesterone production by porcine granulosa cells.
Topics: 2-Methoxyestradiol; Androstenedione; Animals; Cell Count; Cells, Cultured; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Estrogens, Catechol; Female; Flutamide; Follicle Stimulating Hormone; Granulosa Cells; Ovum; Progesterone; Swine; Testosterone | 1988 |
Testosterone suppression of ornithine decarboxylase activity in rat Sertoli cells.
Topics: Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Enzyme Induction; Estradiol; Flutamide; Follicle Stimulating Hormone; Male; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Sertoli Cells; Testosterone | 1988 |
Ability of progesterone to reverse anti-androgen (hydroxyflutamide)-induced interference with the preovulatory LH surge and ovulation in PMSG-primed immature rats.
Topics: Anilides; Animals; Female; Flutamide; Gonadotropins, Equine; Luteinizing Hormone; Ovulation; Progesterone; Rats; Rats, Inbred Strains; Sexual Maturation | 1989 |
Inhibition of rat testicular 17 alpha-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro.
Topics: Aldehyde-Lyases; Androgen Antagonists; Animals; Cyproterone; Cyproterone Acetate; Cytochrome P-450 Enzyme System; Flutamide; Imidazoles; Imidazolidines; Kinetics; Male; Microsomes; Rats; Rats, Inbred Strains; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Testis | 1987 |
Inhibition of 20 alpha-hydroxysteroid dehydrogenase activity by follicle-stimulating hormone and androgens in cultured rat granulosa cells: a search for the mechanism of action.
Topics: 20-alpha-Hydroxysteroid Dehydrogenase; 20-Hydroxysteroid Dehydrogenases; Androgens; Androstenedione; Animals; Bucladesine; Cells, Cultured; Cholera Toxin; Dihydrotestosterone; Estradiol; Estrone; Female; Flutamide; Follicle Stimulating Hormone; Granulosa Cells; Progesterone; Rats; Rats, Inbred Strains; Testosterone | 1985 |
Human chorionic gonadotropin and luteinizing hormone-releasing hormone reverse the blockade of ovulation in pregnant mare's serum gonadotropin-primed immature rats by the anti-androgenic drug, hydroxyflutamide.
Topics: Anilides; Animals; Body Fluids; Chorionic Gonadotropin; Female; Flutamide; Gonadotropin-Releasing Hormone; Gonadotropins, Equine; Humans; Organ Size; Ovary; Ovulation; Pituitary Gland; Rats; Rats, Inbred Strains | 1988 |
The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment.
Topics: Administration, Oral; Anilides; Flutamide; Humans; Male; Prostatic Neoplasms | 1988 |
Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line.
Topics: Androgen Antagonists; Androstenedione; Breast Neoplasms; Cell Division; Cell Line; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Flutamide; Humans; Piperidines; Raloxifene Hydrochloride; Receptors, Androgen; Receptors, Estrogen; Testosterone | 1988 |
Plasma levels of hydroxy-flutamide in patients with prostatic cancer receiving the combined hormonal therapy: an LHRH agonist and flutamide.
Topics: Adult; Aged; Anilides; Antineoplastic Combined Chemotherapy Protocols; Flutamide; Gonadotropin-Releasing Hormone; Humans; Kinetics; Male; Middle Aged; Prostatic Neoplasms; Testosterone; Triptorelin Pamoate | 1988 |
Interference with the preovulatory luteinizing hormone surge and blockade of ovulation in immature pregnant mare's serum gonadotropin-primed rats with the anti-androgenic drug, hydroxyflutamide.
Topics: Androgens; Anilides; Animals; Chorionic Gonadotropin; Estrus; Female; Flutamide; Gonadotropins, Equine; Luteinizing Hormone; Ovulation; Proestrus; Rats; Rats, Inbred Strains; Uterus | 1987 |
Androgen dependence of the Dunning R3327G cell line in monolayer culture.
Topics: Androgen Antagonists; Androgens; Animals; Cell Division; Cell Line; Dihydrotestosterone; Flutamide; Male; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Rats; Tumor Cells, Cultured | 1987 |
Inhibition of cell nuclear androgen receptor binding and copulation in male rats by an antiandrogen, Sch 16423.
Topics: Anilides; Animals; Binding, Competitive; Cell Nucleus; Copulation; Dose-Response Relationship, Drug; Female; Flutamide; Male; Rats; Rats, Inbred Strains; Receptors, Androgen; Testosterone; Time Factors | 1986 |
Control of granulosa cell lactate production by follicle-stimulating hormone and androgen.
Topics: Androgens; Animals; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Synergism; Female; Flutamide; Follicle Stimulating Hormone; Granulosa Cells; Lactates; Osmolar Concentration; Progesterone; Rats; Rats, Inbred Strains; Testosterone; Time Factors | 1985 |
Hypothalamic-pituitary function in experimental uremic hypogonadism.
Topics: Animals; Flutamide; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hypogonadism; Hypothalamo-Hypophyseal System; Hypothalamus; Luteinizing Hormone; Male; Metabolic Clearance Rate; Naloxone; Orchiectomy; Pituitary Gland; Rats; Uremia | 1985 |
Steroidogenic capabilities of various compartments of rat ovarian follicles in culture.
Topics: Androgens; Animals; Culture Techniques; Estrogens; Female; Flutamide; Granulosa Cells; Ovarian Follicle; Progesterone; Rats; Steroids; Theca Cells | 1984 |
Effect of androgens on the ovarian morphology of the hypophysectomized rat.
Topics: Animals; Diethylstilbestrol; Dihydrotestosterone; Female; Flutamide; Hypophysectomy; Ovarian Follicle; Rats; Testosterone | 1983 |
Steroidal actions and voluntary drinking of ethanol by male and female rats.
Topics: Alcohol Dehydrogenase; Alcohol Drinking; Alcohol Oxidoreductases; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Estradiol; Estrogen Antagonists; Estrogens; Ethinyl Estradiol; Female; Flutamide; Liver; Male; Rats; Rats, Inbred Strains; Tamoxifen | 1981 |
Antiandrogen effects on androgen-responsive mammary tumour cells in culture.
Topics: Anilides; Animals; Cell Division; Cells, Cultured; Cyproterone; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Mammary Neoplasms, Experimental; Mice; Receptors, Androgen; Testosterone | 1981 |
Effect of alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide (Sch 16423) on serum testosterone and LH in rats.
Topics: Androgen Antagonists; Anilides; Animals; Flutamide; Luteinizing Hormone; Male; Rats; Testosterone | 1981 |
Inhibitory effect of hydroxyflutamide plus tamoxifen on oestradiol-induced growth of MCF-7 breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Dihydrotestosterone; Drug Synergism; Estradiol; Estrogen Antagonists; Flutamide; Humans; Neoplasms, Hormone-Dependent; Tamoxifen; Tumor Cells, Cultured | 1995 |
In vivo and in vitro effects of androgen on fibroblast growth factor-2 concentrations in the human prostate.
Topics: Androgen Antagonists; Cell Division; Culture Techniques; Dihydrotestosterone; Fibroblast Growth Factor 2; Flutamide; Humans; Male; Megestrol; Megestrol Acetate; Orchiectomy; Prostate; Prostatic Hyperplasia; Radioimmunoassay | 1994 |
Growth of LNCaP human prostate cancer cells is stimulated by estradiol via its own receptor.
Topics: Androgen Antagonists; Base Sequence; Breast Neoplasms; Cell Division; Cell Line; Cell Nucleus; Cytosol; Dihydrotestosterone; DNA Primers; DNA, Neoplasm; Estradiol; Female; Flutamide; Gene Expression; Humans; Kinetics; Male; Molecular Sequence Data; Polymerase Chain Reaction; Prostate-Specific Antigen; Prostatic Neoplasms; Radioligand Assay; Receptors, Estradiol; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Androgen alters the dendritic arbors of SNB motoneurons by acting upon their target muscles.
Topics: Animals; Axonal Transport; Cholera Toxin; Dendrites; Drug Implants; Flutamide; Horseradish Peroxidase; Male; Motor Neurons; Muscle, Skeletal; Orchiectomy; Organ Size; Rats; Rats, Sprague-Dawley; Seminal Vesicles; Testosterone | 1995 |
Atypical androgen receptor in the human melanoma cell line IIB-MEL-J.
Topics: Androgen Antagonists; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Hormonal; Binding, Competitive; Cell Division; Dihydrotestosterone; Estradiol; Flutamide; Humans; Hydrocortisone; Immunohistochemistry; Male; Melanoma; Metribolone; Mice; Mice, Nude; Progesterone; Receptors, Androgen; Testosterone; Tumor Cells, Cultured | 1995 |
Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding.
Topics: Amino Acid Sequence; Androgen Antagonists; Animals; Base Sequence; Binding Sites; Flutamide; Haplorhini; Ligands; Male; Methionine; Molecular Sequence Data; Mutation; Prostatic Neoplasms; Protein Binding; Protein Conformation; Receptors, Androgen; Structure-Activity Relationship; Transcriptional Activation; Transfection; Valine | 1995 |
Sex steroids up-regulate E-cadherin expression in hormone-responsive LNCaP human prostate cancer cells.
Topics: Androgen Antagonists; Cadherins; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Gonadal Steroid Hormones; Humans; Immunoblotting; Immunohistochemistry; Male; Prostatic Neoplasms | 1995 |
Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Blood Physiological Phenomena; Cell Division; Dexamethasone; Dihydrotestosterone; Estradiol; Female; Flutamide; Mammary Neoplasms, Experimental; Medroxyprogesterone Acetate; Mice; Mice, Inbred BALB C; Mifepristone; Ovariectomy; Progesterone; Tumor Cells, Cultured | 1995 |
Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide.
Topics: Androgen Receptor Antagonists; Androgens; Animals; Binding, Competitive; Cell Line; Dihydrotestosterone; DNA; Flutamide; Fungicides, Industrial; Humans; Kinetics; Male; Oxazoles; Receptors, Androgen; Recombinant Proteins; Reproduction; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1995 |
Androgens rapidly increase the cytosolic calcium concentration in Sertoli cells.
Topics: Androgen Antagonists; Androgens; Animals; Calcium; Cells, Cultured; Cyclic AMP; Cytosol; Dihydrotestosterone; Drug Synergism; Finasteride; Flutamide; Follicle Stimulating Hormone; Kinetics; Male; Progesterone; Rats; Rats, Wistar; Sertoli Cells; Spermatogenesis; Testosterone; Time Factors | 1995 |
Androgen regulation of thromboxane A2 receptors.
Topics: Animals; Aorta; Blood Platelets; Cells, Cultured; Estradiol; Flutamide; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Muscle, Smooth, Vascular; Rats; Receptors, Thromboxane; Testosterone; Tumor Cells, Cultured | 1995 |
Androgens induce divergent proliferative responses in human breast cancer cell lines.
Topics: Androgen Receptor Antagonists; Androgens; Breast Neoplasms; Cell Division; Dihydrotestosterone; Flutamide; Humans; Imidazoles; Imidazolidines; Nandrolone; Oligonucleotides, Antisense; Receptors, Androgen; Tumor Cells, Cultured | 1995 |
Androgenic and antiandrogenic control on epidermal growth factor, epidermal growth factor receptor, and androgen receptor expression in human prostate cancer cell line LNCaP.
Topics: Androgen Antagonists; Blotting, Northern; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Flutamide; Gene Expression; Humans; Male; Metribolone; Prostatic Neoplasms; Protein Binding; Radioimmunoassay; Receptors, Androgen; RNA, Messenger; Time Factors; Tumor Cells, Cultured | 1995 |
Finasteride dose-dependently reduces the proliferation rate of the LnCap human prostatic cancer cell line in vitro.
Topics: Androgen Antagonists; Cell Division; Cyproterone Acetate; Dihydrotestosterone; Dose-Response Relationship, Drug; Finasteride; Flutamide; Humans; Linear Models; Male; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1995 |
Androgen directs sexual differentiation of laryngeal innervation in developing Xenopus laevis.
Topics: Animals; Axons; Dihydrotestosterone; Female; Flutamide; Laryngeal Muscles; Laryngeal Nerves; Male; Microscopy, Electron; Muscle Development; Sex Differentiation; Testosterone; Xenopus laevis | 1994 |
Behavioral effects of an antiandrogen in adult male rhesus macaques (Macaca mulatta).
Topics: Androgen Antagonists; Animals; Arousal; Dose-Response Relationship, Drug; Female; Flutamide; Macaca mulatta; Male; Sexual Behavior, Animal; Social Environment; Testosterone; Yawning | 1994 |
5-En-androstene-3 beta,17 beta-diol inhibits the growth of MCF-7 breast cancer cells when oestrogen receptors are blocked by oestradiol.
Topics: Androstenediol; Breast Neoplasms; Cell Division; Diethylstilbestrol; Dihydrotestosterone; Estradiol; Flutamide; Humans; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured | 1994 |
Androgen receptor function during undernutrition.
Topics: Androgen Receptor Antagonists; Animals; Feedback; Flutamide; Food Deprivation; Hypothalamus; Luteinizing Hormone; Male; Pituitary Gland; Prostate; Rats; Rats, Wistar; Receptors, Androgen | 1994 |
Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon.
Topics: Androgen Antagonists; Androgens; Cell Cycle; Cell Division; Dihydrotestosterone; Drug Resistance; Flutamide; Humans; Immunohistochemistry; Interferon-beta; Male; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 1994 |
Androgen regulation of cell adhesion molecule gene expression in rat prostate during organ degeneration. C-CAM belongs to a class of androgen-repressed genes associated with enriched stem/amplifying cell population after prolonged castration.
Topics: Adenosine Triphosphatases; Androgen Antagonists; Animals; Antigens, CD; Apoptosis; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Epithelial Cells; Epithelium; Estradiol; Flutamide; Gene Expression; Immunohistochemistry; Kidney; Liver; Male; Orchiectomy; Organ Specificity; Prostate; Rats; Rats, Sprague-Dawley; Seminal Vesicles; Testosterone; Time Factors | 1994 |
Influence of the anti-androgen hydroxyflutamide on in vitro development of mouse embryos.
Topics: Androgen Antagonists; Animals; Blastomeres; Cells, Cultured; Cleavage Stage, Ovum; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Embryonic Development; Estradiol; Female; Flutamide; Mice; Mice, Inbred Strains; Pregnancy; Progesterone; Testosterone | 1993 |
Antiandrogens inhibit human androgen receptor-dependent gene transcription activation in the human prostate cancer cells LNCaP.
Topics: Amino Acid Sequence; Androgen Antagonists; Binding, Competitive; Blotting, Western; Chloramphenicol O-Acetyltransferase; Cyproterone Acetate; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Gene Expression Regulation, Viral; Humans; Imidazoles; Imidazolidines; Male; Mammary Tumor Virus, Mouse; Molecular Sequence Data; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1994 |
Interaction of antiandrogen-androgen receptor complexes with DNA and transcription activation.
Topics: Androgen Antagonists; Animals; Binding, Competitive; Blotting, Western; Cell Line; Chloramphenicol O-Acetyltransferase; Chlorocebus aethiops; Cyproterone Acetate; Dihydrotestosterone; DNA; Flutamide; Gene Expression Regulation; Humans; Imidazoles; Imidazolidines; Kidney; Kinetics; Mammary Tumor Virus, Mouse; Metribolone; Receptors, Androgen; Recombinant Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 1993 |
Effects of antiandrogens on transformation and transcription activation of wild-type and mutated (LNCaP) androgen receptors.
Topics: Adenocarcinoma; Alanine; Amino Acid Sequence; Androgen Antagonists; Anilides; Animals; Blotting, Western; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyproterone Acetate; Dose-Response Relationship, Drug; Flutamide; Humans; Male; Metribolone; Mutagenesis, Site-Directed; Nitriles; Point Mutation; Prostatic Neoplasms; Receptors, Androgen; Recombinant Proteins; Threonine; Tosyl Compounds; Transcription, Genetic; Transfection; Transformation, Genetic; Tumor Cells, Cultured | 1993 |
Suppression of sodium channel function in differentiating C2 muscle cells stably overexpressing rat androgen receptors.
Topics: Acetylcholine; Androgen Antagonists; Animals; Bungarotoxins; Cell Differentiation; Cell Line; Dihydrotestosterone; Flutamide; Gene Expression; Metribolone; Mice; Muscles; Rats; Receptors, Androgen; Receptors, Cholinergic; Sodium Channels; Transfection | 1994 |
Steroid requirement for androgen receptor dimerization and DNA binding. Modulation by intramolecular interactions between the NH2-terminal and steroid-binding domains.
Topics: Androgens; Animals; Baculoviridae; Base Sequence; Binding Sites; Cell Line; Cyproterone Acetate; DNA; Flutamide; Genetic Vectors; Humans; Macromolecular Substances; Mifepristone; Molecular Sequence Data; Moths; Receptors, Androgen; Recombinant Proteins; Transfection | 1993 |
Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells.
Topics: 17-Hydroxysteroid Dehydrogenases; Breast Neoplasms; Dexamethasone; Dihydrotestosterone; Estradiol; Estrone; Flutamide; Humans; Kinetics; Medroxyprogesterone Acetate; Receptors, Androgen; Tumor Cells, Cultured | 1993 |
Androstenedione increases thromboxane A2 receptors in human erythroleukemia cells.
Topics: Androgen Antagonists; Androstenedione; Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Cells, Cultured; Drug Interactions; Fatty Acids, Unsaturated; Flutamide; Humans; Indomethacin; Iodine Radioisotopes; Kinetics; Leukemia, Erythroblastic, Acute; Muscle, Smooth, Vascular; Radioligand Assay; Rats; Receptors, Thromboxane; Testosterone; Time Factors; Tumor Cells, Cultured | 1996 |
Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; Dihydrotestosterone; DNA-Binding Proteins; Flutamide; Humans; Male; Molecular Sequence Data; Nuclear Receptor Coactivators; Oncogene Proteins; Prostate; Prostatic Neoplasms; Receptors, Androgen; Receptors, Steroid; Recombinant Proteins; RNA, Messenger; Testosterone; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Agonist and antagonist activities of hydroxyflutamide and Casodex relate to androgen receptor stabilization.
Topics: Androgen Antagonists; Anilides; Binding, Competitive; Cells, Cultured; Flutamide; Nitriles; Receptors, Androgen; Tosyl Compounds | 1996 |
Androgen-like and anti-androgen-like effects of antiprogestins in human mammary cancer cells.
Topics: Androgen Antagonists; Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Cell Division; Dihydrotestosterone; Estrenes; Flutamide; Gonanes; Humans; Mifepristone; Models, Biological; Progestins; Receptors, Androgen; Transfection; Tumor Cells, Cultured | 1996 |
Effects of short-term exposure to hydroxyflutamide in utero on the development of the reproductive tract in male mice.
Topics: Androgen Antagonists; Androgens; Animals; Epididymis; Female; Flutamide; Genitalia, Male; Gestational Age; Hypospadias; Male; Mice; Mice, Inbred Strains; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Prostate; Rats; Seminal Vesicles; Spermatogenesis; Testis; Testosterone | 1995 |
New and validated high-performance liquid chromatographic method for determination of hydroxyflutamide in human plasma.
Topics: Androgen Antagonists; Chromatography, High Pressure Liquid; Drug Stability; Flutamide; Humans; Reproducibility of Results | 1996 |
Androgen and glucocorticoid regulation of androgen receptor cDNA expression.
Topics: Cell Line; Cyproterone Acetate; Cytomegalovirus; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Flutamide; Gene Expression; Glucocorticoids; Humans; Metribolone; Promoter Regions, Genetic; Protein Biosynthesis; Receptors, Androgen; Receptors, Glucocorticoid; RNA, Messenger; Testosterone Congeners; Time Factors; Transfection; Tumor Cells, Cultured | 1995 |
Antiandrogen microimplants into the rostral medial preoptic area decrease gamma-aminobutyric acidergic neuronal activity and increase luteinizing hormone secretion in the intact male rat.
Topics: Androgen Antagonists; Animals; Drug Implants; Flutamide; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoenzymes; Luteinizing Hormone; Male; Neurons; Preoptic Area; Rats; Rats, Sprague-Dawley; RNA, Messenger; Testosterone | 1996 |
Regulation by gonadotropins of the messenger ribonucleic acid for P450 side-chain cleavage, P450(17) alpha-hydroxylase/C17,20-lyase, and 3 beta-hydroxysteroid dehydrogenase in cultured pig Leydig cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Aminoglutethimide; Animals; Aromatase Inhibitors; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Flutamide; Gene Expression Regulation, Enzymologic; Gonadotropins; Kinetics; Leydig Cells; Luteinizing Hormone; Male; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Swine; Testosterone | 1996 |
Inhibition of male sex behavior by androgen receptor blockade in preoptic area or hypothalamus, but not amygdala or septum.
Topics: Amygdala; Androgen Antagonists; Animals; Flutamide; Hypothalamus; Male; Preoptic Area; Rats; Septal Nuclei; Sexual Behavior, Animal | 1996 |
Hsp90 regulates androgen receptor hormone binding affinity in vivo.
Topics: Androgen Antagonists; Binding, Competitive; Flutamide; HSP90 Heat-Shock Proteins; Humans; Models, Chemical; Receptors, Androgen; Saccharomyces cerevisiae | 1996 |
Androgen independence of primary epithelial cultures of the prostate is associated with a down-regulation of androgen receptor gene expression.
Topics: Androgen Antagonists; Androgens; Base Sequence; Blotting, Northern; Cell Division; Dihydrotestosterone; DNA, Neoplasm; Dose-Response Relationship, Drug; Down-Regulation; Epithelium; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Sequence Data; Polymerase Chain Reaction; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1996 |
Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.
Topics: DDT; Dose-Response Relationship, Drug; Endocrine Glands; Environmental Pollutants; Flutamide; Hormones; Humans; In Vitro Techniques; Insecticides; Methoxychlor; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Reproducibility of Results; Saccharomyces cerevisiae; Sensitivity and Specificity; Transcription, Genetic | 1997 |
Androgen-induced inhibition of proliferation in human breast cancer MCF7 cells transfected with androgen receptor.
Topics: Androgen Antagonists; Androgens; Anilides; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; Flutamide; Humans; In Vitro Techniques; Metribolone; Nandrolone; Nitriles; Receptors, Androgen; Testosterone; Testosterone Congeners; Tosyl Compounds; Transfection; Tumor Cells, Cultured | 1997 |
[Does interferon-alpha enhance the effect of tamoxifen-medroxyprogesterone acetate and hydroxyflutamide on in vitro tumor cells?].
Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Flutamide; Humans; Interferon-alpha; Medroxyprogesterone Acetate; Ovarian Neoplasms; Tamoxifen; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells.
Topics: Androgen Antagonists; Animals; Chromosome Mapping; Dehydroepiandrosterone; Epithelium; Estradiol; Flutamide; Haplorhini; Humans; Ligands; Male; Mutation; Progesterone; Prostatic Neoplasms; Receptors, Androgen; Transcription, Genetic; Transcriptional Activation; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 1997 |
Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters.
Topics: Androgen Antagonists; Anilides; Animals; Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Division; Dose-Response Relationship, Drug; Flutamide; Glycoproteins; Humans; Imidazoles; Imidazolidines; Membrane Transport Proteins; Mice; Neoplasm Proteins; Nitriles; Tosyl Compounds; Tumor Cells, Cultured | 1997 |
Hydroxyflutamide may not always be a pure antiandrogen.
Topics: Androgen Antagonists; Flutamide; Humans; Male; Nuclear Receptor Coactivators; Oncogene Proteins; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Trans-Activators; Transcription Factors | 1997 |
Non-steroidal L-245,976 acts as a classical antiandrogen in vitro.
Topics: Amides; Androgen Antagonists; Androgen-Binding Protein; Androgens; Aniline Compounds; Animals; Cell Division; Cell Line; CHO Cells; Colorimetry; Cricetinae; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flutamide; Formazans; Humans; Male; Receptors, Androgen; Recombinant Proteins; Testosterone; Tetrazolium Salts; Thiazoles; Transcriptional Activation; Transfection; Vas Deferens | 1997 |
Synergistic activation of androgen receptor by androgen and luteinizing hormone-releasing hormone in prostatic carcinoma cells.
Topics: Androgen Antagonists; Anilides; Bucladesine; Cell Line; Chloramphenicol O-Acetyltransferase; Cyclic AMP; Flutamide; Genes, Reporter; Gonadotropin-Releasing Hormone; Humans; Kinetics; Male; Metribolone; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Testosterone Congeners; Tosyl Compounds; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1997 |
Estrogenic and progestagenic activities of physiologic and synthetic androgens, as measured by in vitro bioassays.
Topics: Adenocarcinoma; Alkaline Phosphatase; Androgen Antagonists; Androgens; Breast Neoplasms; Cyproterone Acetate; Endometrial Neoplasms; Estradiol; Estrogen Antagonists; Female; Flutamide; Gonanes; Humans; Mifepristone; Polyunsaturated Alkamides; Progestins; Tamoxifen; Testosterone; Testosterone Congeners; Tumor Cells, Cultured | 1997 |
Interaction of mouse placental lactogens and androgens in regulating progesterone release in cultured mouse luteal cells.
Topics: Androgen Receptor Antagonists; Androgens; Androstenedione; Animals; Aromatase Inhibitors; Cattle; Cells, Cultured; Cycloheximide; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Fadrozole; Female; Flutamide; Luteal Cells; Mice; Placental Lactogen; Pregnancy; Progesterone; Prolactin; Protein Synthesis Inhibitors; Rabbits; Testosterone | 1997 |
Concerted stimulation of rat granulosa cell deoxyribonucleic acid synthesis by sex steroids and follicle-stimulating hormone.
Topics: Androgen Antagonists; Androgens; Androstenedione; Androsterone; Animals; Bucladesine; Cells, Cultured; Diethylstilbestrol; Dihydrotestosterone; DNA; Estradiol; Female; Flutamide; Follicle Stimulating Hormone; Granulosa Cells; Insulin; Insulin-Like Growth Factor I; Kinetics; Medroxyprogesterone; Ovary; Progesterone; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Testosterone; Thymidine | 1997 |
Differential in vivo regulation of steroid hormone receptor activation by Cdc37p.
Topics: Amino Acid Sequence; Androgen Antagonists; Cell Cycle Proteins; Chaperonins; Desoxycorticosterone; Dihydrotestosterone; Drosophila Proteins; Flutamide; Genes, Reporter; Humans; Ligands; Molecular Chaperones; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Receptors, Androgen; Receptors, Glucocorticoid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature; Thermodynamics; Transcriptional Activation | 1997 |
Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5alpha-dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons.
Topics: Animals; Cells, Cultured; Dihydrotestosterone; Flutamide; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Humans; Hypothalamus; Mice; Neurons; Receptors, Androgen; RNA, Messenger | 1998 |
The role of transforming growth factor-beta1, -beta2, and -beta3 in androgen-responsive growth of NRP-152 rat prostatic epithelial cells.
Topics: Androgen Antagonists; Androgens; Animals; Antibodies; Cell Division; Cell Line; Dihydrotestosterone; Down-Regulation; Finasteride; Flutamide; Male; Prostate; Rats; Testosterone; Transforming Growth Factor beta | 1998 |
Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.
Topics: Androgen Antagonists; Androgens; Anilides; Cyproterone Acetate; Drug Interactions; Flutamide; Humans; Imidazoles; Male; Mifepristone; Nitriles; Nuclear Receptor Coactivators; Oncogene Proteins; Prostatic Neoplasms; Protein Binding; Protein Conformation; Tosyl Compounds; Trans-Activators; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 1998 |
Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Antineoplastic Agents, Hormonal; Carcinoma, Hepatocellular; DDT; Dihydrotestosterone; Estradiol; Flutamide; Humans; Insecticides; Isomerism; Methoxychlor; Progesterone; Receptors, Androgen; Testosterone; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line.
Topics: Adrenal Glands; Aged; Alkaline Phosphatase; Androgen Antagonists; Androgens; Cell Division; Cell Line; Collagen; Dehydroepiandrosterone; Dihydrotestosterone; DNA-Binding Proteins; Early Growth Response Transcription Factors; Flutamide; Gene Expression Regulation; Humans; Kruppel-Like Transcription Factors; Male; Osteoblasts; Osteocalcin; Testosterone; Transcription Factors; Transforming Growth Factor beta | 1998 |
Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells.
Topics: Androgens; Androstane-3,17-diol; Androstenediol; Anilides; Flutamide; Humans; Male; Mutation; Nitriles; Nuclear Receptor Coactivators; Oncogene Proteins; Prostatic Neoplasms; Protein Conformation; Receptors, Androgen; Steroids; Testosterone; Tosyl Compounds; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1998 |
Phorbol ester causes ligand-independent activation of the androgen receptor.
Topics: Animals; Chloramphenicol O-Acetyltransferase; Cyclic AMP-Dependent Protein Kinases; Flutamide; Genes, Reporter; Humans; Ligands; Mammary Tumor Virus, Mouse; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Rabbits; Receptors, Androgen; Receptors, Glucocorticoid; Receptors, Progesterone; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1998 |
Functional characterization of mutant androgen receptors from androgen-independent prostate cancer.
Topics: Amino Acid Substitution; Androgen Antagonists; Androgens; Androstenedione; Animals; beta-Galactosidase; Cell Line; Dihydrotestosterone; Estradiol; Flutamide; Genes, Reporter; Imidazoles; Imidazolidines; Luciferases; Male; Point Mutation; Progesterone; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Transfection | 1997 |
Evidence for androgen receptor gene expression and growth inhibitory effect of dihydrotestosterone on human adrenocortical cells.
Topics: Adrenal Cortex; Androgen Antagonists; Cell Division; Cells, Cultured; Cyproterone Acetate; Dihydrotestosterone; Female; Flutamide; Gene Expression; Humans; Immunohistochemistry; Male; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 1998 |
Androgens down-regulate bcl-2 protooncogene expression in ZR-75-1 human breast cancer cells.
Topics: Androgen Antagonists; Androgens; Breast Neoplasms; Caspase 3; Caspases; Dihydrotestosterone; Down-Regulation; Estradiol; Estrogens; Female; Flutamide; Humans; Immunohistochemistry; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 1999 |
Androgens regulate bone resorption activity of isolated osteoclasts in vitro.
Topics: Acid Phosphatase; Androgen Antagonists; Androgens; Animals; Bone Resorption; Cathepsin B; Chickens; Dihydrotestosterone; Flutamide; Genes, Reporter; Humans; Isoenzymes; Metribolone; Mice; Osteoclasts; Receptors, Androgen; Regulatory Sequences, Nucleic Acid; Tartrate-Resistant Acid Phosphatase; Transfection; Transforming Growth Factor beta | 1999 |
From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.
Topics: Androgen Antagonists; Androgens; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Flavonoids; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Mutagenesis, Site-Directed; Nuclear Receptor Coactivators; Oncogene Proteins; Prostate-Specific Antigen; Prostatic Neoplasms; Receptor, ErbB-2; Receptors, Androgen; Signal Transduction; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrphostins | 1999 |
Phosphorylation/dephosphorylation of androgen receptor as a determinant of androgen agonistic or antagonistic activity.
Topics: Androgen Antagonists; Androgens; Anilides; Animals; Base Sequence; Dihydrotestosterone; Estradiol; Estramustine; Flutamide; Humans; Ligands; Male; Molecular Sequence Data; Nitriles; Phosphorylation; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Tosyl Compounds; Tumor Cells, Cultured | 1999 |
Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats.
Topics: Androgen Antagonists; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Flutamide; Male; Rats; Rats, Sprague-Dawley | 1998 |
Regulation of GCDFP-15 expression in human mammary cancer cells.
Topics: Androgen Antagonists; Anilides; Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Division; Dihydrotestosterone; Flutamide; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Membrane Transport Proteins; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tosyl Compounds; Tumor Cells, Cultured | 1999 |
The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Cell Line; Dihydrotestosterone; Flutamide; Humans; Interleukin-1; Interleukin-6; NF-kappa B; Osteoblasts; Paracrine Communication; Protein Binding; RNA, Messenger; Stimulation, Chemical; Tumor Necrosis Factor-alpha | 1999 |
Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells.
Topics: Androgen Antagonists; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cycloheximide; Dihydrotestosterone; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flutamide; Humans; Male; Metribolone; Microtubule-Associated Proteins; Prostatic Neoplasms; Protein Synthesis Inhibitors; Receptors, Androgen; Testosterone Congeners; Trastuzumab; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1999 |
Domain requirements of DnaJ-like (Hsp40) molecular chaperones in the activation of a steroid hormone receptor.
Topics: Binding Sites; Binding, Competitive; Flutamide; Gene Deletion; Genetic Complementation Test; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Metribolone; Molecular Chaperones; Mutation; Phenotype; Protein Binding; Protein Structure, Tertiary; Radioligand Assay; Receptors, Androgen; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Suppression, Genetic; Tritium; Zinc Fingers | 1999 |
Androgen receptor expression is greater in macrophages from male than from female donors. A sex difference with implications for atherogenesis.
Topics: Adult; Aged; Arteriosclerosis; Cholesterol Esters; Dihydrotestosterone; Female; Flutamide; Humans; Macrophages; Male; Middle Aged; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Factors | 2000 |
Pharmacokinetics of 2-hydroxyflutamide, a major metabolite of flutamide, in normal and CCl4-poisoned rats.
Topics: Androgen Antagonists; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Flutamide; Male; Rats | 1999 |
7alpha-methyl-19-nortestosterone, a synthetic androgen with high potency: structure-activity comparisons with other androgens.
Topics: Androgen Antagonists; Androgens; Animals; Binding, Competitive; Castration; Cell Line; Flutamide; Genes, Reporter; Male; Nandrolone; Organ Size; Prostate; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Sex Hormone-Binding Globulin; Structure-Activity Relationship; Testosterone; Testosterone Congeners; Transfection | 1999 |
Down-regulation of transforming growth factor beta receptors by androgen in ovarian cancer cells.
Topics: Dihydrotestosterone; Down-Regulation; Female; Flutamide; Gene Expression Regulation; Humans; Ovarian Neoplasms; Receptors, Androgen; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate cancer DU145 cells.
Topics: Androgen Antagonists; Carrier Proteins; Flutamide; Gonadal Steroid Hormones; Histone Acetyltransferases; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Male; Nuclear Receptor Coactivator 1; Nuclear Receptor Coactivators; Oncogene Proteins; Prostatic Neoplasms; Receptors, Androgen; Trans-Activators; Transcription Factors; Tumor Cells, Cultured | 1999 |
Specific recognition of androgens by their nuclear receptor. A structure-function study.
Topics: Amino Acid Sequence; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Binding Sites; Computer Simulation; Cyproterone Acetate; Dose-Response Relationship, Drug; Flutamide; Humans; Ligands; Metribolone; Models, Molecular; Molecular Sequence Data; Nitriles; Progesterone; Promegestone; Receptors, Androgen; Sequence Alignment; Tosyl Compounds; Transcriptional Activation | 2000 |
Isolation and characterization of the androgen receptor mutants with divergent transcriptional activity in response to hydroxyflutamide.
Topics: Amino Acid Sequence; Androgen Antagonists; Animals; Blotting, Western; DNA; Estradiol; Flutamide; Gene Expression; Male; Molecular Sequence Data; Mutagenesis; Point Mutation; Progesterone; Rats; Receptors, Androgen; Saccharomyces cerevisiae; Structure-Activity Relationship; Transcription, Genetic; Transcriptional Activation; Transfection | 2000 |
Rapid androgen actions on calcium signaling in rat sertoli cells and two human prostatic cell lines: similar biphasic responses between 1 picomolar and 100 nanomolar concentrations.
Topics: Androgen Antagonists; Androgens; Animals; Calcium Signaling; Cell Line; Cyproterone Acetate; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Gap Junctions; Humans; Kinetics; Male; Metribolone; Prostate; Prostatic Neoplasms; Rats; Rats, Wistar; Sertoli Cells; Testosterone; Tumor Cells, Cultured | 2000 |
Effects of antiandrogens on chromatin remodeling and transcription of the integrated mouse mammary tumor virus promoter.
Topics: Androgen Antagonists; Animals; Base Sequence; Chromatin; Cyproterone Acetate; DNA Probes; Female; Flutamide; L Cells; Male; Mammary Tumor Virus, Mouse; Mice; Promoter Regions, Genetic; Receptors, Androgen; Transcriptional Activation | 2000 |
Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females.
Topics: Androgen Antagonists; Androstenedione; Animals; Antibodies; Aromatase Inhibitors; Cells, Cultured; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Flutamide; Fulvestrant; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Stress, Mechanical; Tamoxifen; Testosterone; Thymidine | 2000 |
Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.
Topics: Adenocarcinoma; Androgen Antagonists; Androgens; Animals; Binding Sites; Cell Line; COS Cells; Dihydrotestosterone; DNA; Estradiol; Flutamide; Humans; Male; Mice; Mice, Transgenic; Models, Molecular; Mutagenesis; Mutation; Progesterone; Prostatic Neoplasms; Protein Structure, Secondary; Receptors, Androgen; Structure-Activity Relationship; Transcriptional Activation; Transfection | 2001 |
Characterization of androgen receptors in a well-differentiated endometrial adenocarcinoma cell line (Ishikawa).
Topics: Adenocarcinoma; Alkaline Phosphatase; Androgens; Cell Differentiation; Cell Nucleus; Diethylstilbestrol; Dihydrotestosterone; Endometrial Neoplasms; Endometrium; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Flutamide; Fulvestrant; Humans; Metribolone; Progesterone; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2000 |
Testosterone inhibits osteoclast formation stimulated by parathyroid hormone through androgen receptor.
Topics: Androgen Antagonists; Androstenedione; Animals; Aromatase Inhibitors; Cell Division; Cells, Cultured; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Glucuronates; Mice; Mice, Inbred ICR; Osteoclasts; Parathyroid Hormone; Receptors, Androgen; Teriparatide; Testosterone | 2001 |
Dexamethasone blocks antioestrogen- and oxidant-induced death of pituitary tumour cells.
Topics: Adenosine Triphosphate; Cell Death; Dexamethasone; Estradiol; Estrogen Receptor Modulators; Estrone; Flow Cytometry; Flutamide; Fulvestrant; Glucocorticoids; Glyceraldehyde-3-Phosphate Dehydrogenases; Gonanes; Humans; Hydrogen Peroxide; Microscopy, Fluorescence; Mifepristone; Pituitary Neoplasms; Reactive Oxygen Species; Receptor Cross-Talk; Receptors, Cell Surface; Transfection; Tumor Cells, Cultured | 2001 |
Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands.
Topics: Amino Acid Substitution; Binding Sites; Binding, Competitive; Crystallography, X-Ray; Flutamide; Humans; Imidazoles; Imidazolidines; Ligands; Models, Molecular; Mutation; Protein Conformation; Protein Structure, Tertiary; Receptors, Androgen; Receptors, Progesterone; Stereoisomerism; Structure-Activity Relationship | 2001 |
The subnuclear three-dimensional image analysis of androgen receptor fused to green fluorescence protein.
Topics: Active Transport, Cell Nucleus; Androgen Antagonists; Animals; Cell Nucleus; COS Cells; Dihydrotestosterone; Euchromatin; Flutamide; Green Fluorescent Proteins; Heterochromatin; Humans; Ligands; Luminescent Proteins; Microscopy, Confocal; Plasmids; Point Mutation; Progesterone; Protein Binding; Receptors, Androgen; Receptors, Progesterone; Recombinant Fusion Proteins; Transcription, Genetic; Transcriptional Activation | 2001 |
Determination of 2-hydroxyflutamide in human plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.
Topics: Adult; Androgen Antagonists; Chromatography, High Pressure Liquid; Female; Flutamide; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2001 |
Use of the probasin promoter ARR2PB to express Bax in androgen receptor-positive prostate cancer cells.
Topics: Adenoviridae; Androgen Antagonists; Androgen-Binding Protein; Animals; Apoptosis; Arabidopsis Proteins; bcl-2-Associated X Protein; Blotting, Western; DNA-Binding Proteins; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Promoter Regions, Genetic; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen; Transcription Factors; Transplantation, Heterologous; Tumor Cells, Cultured; Up-Regulation | 2001 |
Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and/or hAR for endocrine screening.
Topics: Adenoviridae; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; Cell Line; Dexamethasone; Dihydrotestosterone; Flutamide; Gene Expression; Glucocorticoids; Humans; Luciferases; Mammary Tumor Virus, Mouse; Pesticides; Progesterone; Promoter Regions, Genetic; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Recombinant Fusion Proteins; Transduction, Genetic; Transfection; Tumor Cells, Cultured | 2002 |
The amino terminus of the human AR is target for corepressor action and antihormone agonism.
Topics: Androgen Antagonists; Anilides; Animals; Catalytic Domain; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cyproterone Acetate; DNA-Binding Proteins; Flutamide; Haplorhini; Humans; Ligands; Male; Nitriles; Nuclear Receptor Co-Repressor 2; Point Mutation; Protein Conformation; Receptors, Androgen; Repressor Proteins; Tosyl Compounds; Transcriptional Activation; Transfection | 2002 |
Cytotoxicity of flutamide and 2-hydroxyflutamide and their effects on CYP1A2 mRNA in primary rat hepatocytes.
Topics: Androgen Antagonists; Animals; Cells, Cultured; Cytochrome P-450 CYP1A2; Flutamide; Hepatocytes; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2002 |
Stabilization of androgen receptor protein is induced by agonist, not by antagonists.
Topics: Androgen Receptor Antagonists; Androgens; Anilides; Animals; Blotting, Northern; Blotting, Western; CHO Cells; Cricetinae; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Humans; Ligands; Luciferases; Nitriles; Plasmids; Receptors, Androgen; RNA Processing, Post-Transcriptional; Time Factors; Tosyl Compounds; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2002 |
Androgens protect against apolipoprotein E4-induced cognitive deficits.
Topics: Androgen Antagonists; Androgens; Animals; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain; Cognition; Cognition Disorders; Dihydrotestosterone; Female; Flutamide; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Receptors, Androgen; Recognition, Psychology; Sex Factors; Testosterone | 2002 |
Acquisition of agonistic properties of nonsteroidal antiandrogens after treatment with oncostatin M in prostate cancer cells.
Topics: Androgen Antagonists; Anilides; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Chloramphenicol; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Enzyme Inhibitors; Flavonoids; Flutamide; Growth Inhibitors; Humans; Interleukin-6; Male; Nitriles; Oncostatin M; Peptides; Prostatic Neoplasms; Receptors, Androgen; Receptors, Cytokine; Receptors, Oncostatin M; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tosyl Compounds; Transfection; Tumor Cells, Cultured | 2002 |
Pure antiandrogens disrupt the recruitment of coactivator GRIP1 to colocalize with androgen receptor in nuclei.
Topics: Active Transport, Cell Nucleus; Androgen Antagonists; Androgens; Anilides; Animals; Cell Nucleus; Chlorocebus aethiops; COS Cells; Cyproterone Acetate; Flutamide; Nitriles; Nuclear Receptor Coactivator 2; Receptors, Androgen; Subcellular Fractions; Tosyl Compounds; Transcription Factors; Transcriptional Activation | 2002 |
Nerve growth factor induces the re-expression of functional androgen receptors and p75(NGFR) in the androgen-insensitive prostate cancer cell line DU145.
Topics: Androgen Antagonists; Androgens; Apoptosis; Cell Division; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Gene Expression; Humans; Male; Nerve Growth Factor; Prostatic Neoplasms; Receptor, Nerve Growth Factor; Receptors, Androgen; RNA, Messenger; Telomerase; Tumor Cells, Cultured | 2002 |
Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.
Topics: Androgen Antagonists; Cell Division; Cyclin D1; Enzyme Activation; ErbB Receptors; Flutamide; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Receptors, Androgen; Substance Withdrawal Syndrome; Tyrphostins | 2002 |
Effects of hydroxyflutamide in the medial preoptic area or lateral septum on reproductive behaviors in male rats.
Topics: Androgen Antagonists; Animals; Female; Flutamide; Male; Preoptic Area; Rats; Receptors, Androgen; Septal Nuclei; Sexual Behavior, Animal | 2002 |
[Sex-difference on flutamide metabolism in rat liver microsomal cytochrome P450 1A2].
Topics: Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Cell Separation; Cytochrome P-450 CYP1A2; Female; Flutamide; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sex Factors | 2002 |
Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells.
Topics: Androgen Antagonists; Anilides; Calcitriol; Cerulenin; Cycloheximide; Down-Regulation; Enzyme Inhibitors; Fatty Acid Synthases; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Nitriles; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tosyl Compounds; Tumor Cells, Cultured | 2003 |
Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator.
Topics: Animals; Cloning, Molecular; COS Cells; Dihydrotestosterone; Flutamide; Gelsolin; Humans; Male; Mice; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation | 2003 |
Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts.
Topics: 5-alpha-Dihydroprogesterone; Androgen Receptor Antagonists; Androgens; Animals; Cell Division; Cell Survival; DNA-Binding Proteins; ets-Domain Protein Elk-1; Extracellular Signal-Regulated MAP Kinases; Flutamide; Genes, Reporter; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Oligonucleotide Array Sequence Analysis; Osteoblasts; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins; Rats; Receptors, Androgen; Transcription Factors; Tumor Cells, Cultured | 2004 |
Interactions between androgen and growth factors in granulosa cell subtypes of porcine antral follicles.
Topics: Androgen Antagonists; Androgens; Animals; Cell Division; Dihydrotestosterone; DNA; Drug Combinations; Female; Flutamide; Follicle Stimulating Hormone; Granulosa Cells; Growth Substances; Insulin-Like Growth Factor I; Progesterone; Swine; Time Factors | 2004 |
Differential effect of small ubiquitin-like modifier (SUMO)-ylation of the androgen receptor in the control of cooperativity on selective versus canonical response elements.
Topics: Amino Acid Motifs; Animals; Binding Sites; COS Cells; Dimerization; DNA; Flutamide; Genes, Reporter; Genetic Vectors; Immunoprecipitation; Ligands; Luciferases; Lysine; Mutation; Plasmids; Point Mutation; Protein Binding; Receptors, Androgen; Response Elements; Small Ubiquitin-Related Modifier Proteins; Transcription, Genetic; Transcriptional Activation; Transfection; Ubiquitin-Conjugating Enzymes | 2004 |
Ectopic expression of the amino-terminal peptide of androgen receptor leads to androgen receptor dysfunction and inhibition of androgen receptor-mediated prostate cancer growth.
Topics: Active Transport, Cell Nucleus; Base Sequence; Cell Division; Cell Line, Tumor; Drug Interactions; Flutamide; Humans; Interphase; Male; Peptide Fragments; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation; Transfection | 2004 |
Proteasome inhibitors and their combination with antiandrogens: effects on apoptosis, cellular proliferation and viability of prostatic adenocarcinoma cell cultures.
Topics: Adenocarcinoma; Androgen Antagonists; Apoptosis; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Drug Interactions; Flutamide; Humans; Leupeptins; Male; Oligopeptides; Prostatic Neoplasms; Protease Inhibitors; Tumor Cells, Cultured | 2004 |
Effect of organochlorine pesticides on human androgen receptor activation in vitro.
Topics: Androgen Antagonists; Binding, Competitive; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Flutamide; Humans; Inhibitory Concentration 50; Insecticides; Male; Metribolone; Receptors, Androgen; Testosterone Congeners | 2004 |
Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer.
Topics: Amino Acid Sequence; Androgen Antagonists; Animals; Blotting, Western; Cell Nucleus; Chlorocebus aethiops; Consensus Sequence; COS Cells; Drug Stability; Fluorescent Antibody Technique; Flutamide; Gene Expression; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nuclear Receptor Coactivators; Oncogene Proteins; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Structure-Activity Relationship; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Two-Hybrid System Techniques | 2004 |
Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors.
Topics: Analysis of Variance; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Conditioning, Psychological; Copulation; Female; Flutamide; Male; Motivation; Preoptic Area; Rats; Receptors, Androgen; Sexual Behavior, Animal; Social Behavior; Testosterone; Ventromedial Hypothalamic Nucleus; Vocalization, Animal | 2004 |
Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androgen Antagonists; Androgens; Animals; Enzyme Inhibitors; Finasteride; Flutamide; Male; Prostate; Prostatic Hyperplasia; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Testis | 2004 |
The effects of the reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, on testosterone formation by cultured Leydig cells from young adult rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Drug Combinations; Estrogen Antagonists; Flutamide; Insecticides; Leydig Cells; Male; Methoxychlor; Oxazoles; Phenols; Rats; Rats, Sprague-Dawley; Testosterone | 2004 |
Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens.
Topics: Adenosine Triphosphate; Androgen Antagonists; Androgens; Anilides; Animals; Cell Line, Tumor; Cell Nucleus; COS Cells; Cytoplasm; Cytoskeleton; Electrophoresis, Gel, Two-Dimensional; Flutamide; Humans; Immunoblotting; Male; Mass Spectrometry; Microscopy, Confocal; Microscopy, Fluorescence; Nitriles; Prostatic Neoplasms; Protein Transport; Receptors, Androgen; Subcellular Fractions; Tosyl Compounds; Transfection | 2004 |
5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells.
Topics: Androgen Receptor Antagonists; Androgens; Anilides; Calcitriol; Cycloheximide; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Drug Interactions; Flutamide; Gene Expression Regulation, Enzymologic; Humans; Male; Nitriles; Prostatic Neoplasms; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Steroid Hydroxylases; Tosyl Compounds; Tumor Cells, Cultured; Vitamin D3 24-Hydroxylase | 2005 |
Potential action of androstenedione on the proliferation and apoptosis of stromal endometrial cells.
Topics: Actins; Adult; Androstenedione; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Cells, Cultured; Endometrium; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Flutamide; Humans; In Situ Nick-End Labeling; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells | 2004 |
Castration reduces platelet thromboxane A2 receptor density and aggregability.
Topics: Aged; Androgen Antagonists; Blood Platelets; Cardiovascular Diseases; Case-Control Studies; Castration; Cross-Sectional Studies; Flutamide; Humans; Male; Middle Aged; Platelet Aggregation; Prostatic Neoplasms; Receptors, Thromboxane A2, Prostaglandin H2; Testosterone | 2005 |
Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells.
Topics: Androgen Antagonists; Androgens; Animals; Bone Morphogenetic Protein 15; Cell Proliferation; Cells, Cultured; Coculture Techniques; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; Flutamide; Follicle Stimulating Hormone; Granulosa Cells; Growth Differentiation Factor 9; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Mice; Mitogens; Oocytes; Progesterone; Recombinant Proteins; Swine; Testosterone | 2005 |
The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions.
Topics: Amino Acid Motifs; Blotting, Western; Estrogen Receptor alpha; Fluorescence Resonance Energy Transfer; Flutamide; Genetic Vectors; HeLa Cells; Humans; Ligands; Luciferases; Luminescent Proteins; Mammary Tumor Virus, Mouse; Mutation; PPAR gamma; Protein Folding; Protein Structure, Tertiary; Receptors, Androgen; Transcriptional Activation | 2005 |
Prostate cancer PET bioprobes: synthesis of [18F]-radiolabeled hydroxyflutamide derivatives.
Topics: Androgen Antagonists; Fluorine Radioisotopes; Flutamide; Humans; Male; Prostatic Neoplasms; Radionuclide Imaging | 2005 |
Antiandrogens prevent stable DNA-binding of the androgen receptor.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Computer Simulation; DNA; DNA-Binding Proteins; DNA, Neoplasm; Flutamide; Green Fluorescent Proteins; Humans; Liver Neoplasms; Male; Metribolone; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Tosyl Compounds | 2005 |
Co-activator and co-repressor interplay on the human androgen receptor.
Topics: Androgen Antagonists; Androgen-Binding Protein; Androgens; Anilides; Cyproterone Acetate; Flutamide; Humans; Ligands; Male; Nitriles; Protein Binding; Receptors, Androgen; Repressor Proteins; Response Elements; Time Factors; Tosyl Compounds; Trans-Activators; Transcriptional Activation | 2005 |
Androgen effects on hippocampal CA1 spine synapse numbers are retained in Tfm male rats with defective androgen receptors.
Topics: Androgens; Animals; Dendrites; Dendritic Cells; Dihydrotestosterone; Estradiol; Flutamide; Genotype; Hippocampus; Male; Microscopy, Electron; Models, Statistical; Mutation; Neurons; Orchiectomy; Rats; Receptors, Androgen; Sesame Oil; Synapses; Time Factors | 2006 |
Anti-progestogenic effect of flutamide on uterine expression of calbindin-D9k mRNA and protein in immature mice.
Topics: Androgen Antagonists; Animals; Blotting, Northern; Blotting, Western; Calbindins; Dose-Response Relationship, Drug; Female; Flutamide; Gene Expression; Injections, Subcutaneous; Mice; Mice, Inbred ICR; Mifepristone; Molecular Structure; Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S100 Calcium Binding Protein G; Time Factors; Up-Regulation; Uterus | 2006 |
Chiral dimethylamine flutamide derivatives--modeling, synthesis, androgen receptor affinities and carbon-11 labeling.
Topics: Carbon Radioisotopes; Flutamide; Humans; Isotope Labeling; Male; Models, Molecular; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Receptors, Androgen | 2006 |
Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide.
Topics: Animals; Bromine Radioisotopes; Flutamide; Isotope Labeling; Ligands; Male; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Tissue Distribution | 2006 |
Testosterone directly induces progesterone production and interacts with physiological concentrations of LH to increase granulosa cell progesterone production in laying hens (Gallus domesticus).
Topics: Animals; Cells, Cultured; Chickens; Dose-Response Relationship, Drug; Female; Flutamide; Granulosa Cells; Luteinizing Hormone; Oviposition; Progesterone; Testosterone; Time Factors | 2007 |
Ligand-specific dynamics of the androgen receptor at its response element in living cells.
Topics: Adenocarcinoma; Androgen Antagonists; Androgens; Anilides; Animals; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cyproterone Acetate; Dihydrotestosterone; Female; Fluorescence Recovery After Photobleaching; Flutamide; Genes, Reporter; Green Fluorescent Proteins; In Situ Hybridization, Fluorescence; Ligands; Luciferases; Mammary Neoplasms, Animal; Mammary Tumor Virus, Mouse; Metribolone; Mice; Microscopy, Video; Mifepristone; Models, Biological; Nitriles; Plasmids; Promoter Regions, Genetic; Receptors, Androgen; Response Elements; Testosterone; Tosyl Compounds; Transcription, Genetic | 2007 |
The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay.
Topics: Amino Acid Sequence; Amino Acid Substitution; Androgen Antagonists; Anilides; Animals; Cyproterone Acetate; Dihydrotestosterone; Fluoresceins; Fluorescence Resonance Energy Transfer; Flutamide; Ligands; Mifepristone; Nitriles; Oligopeptides; Rats; Receptors, Androgen; Tosyl Compounds | 2007 |
Non-steroidal antiandrogens act as AF-1 agonists under conditions of high androgen-receptor expression.
Topics: Androgens; Anilides; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Flutamide; HeLa Cells; Humans; Male; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Receptors, Interferon; Tosyl Compounds; Transcriptional Activation | 2007 |
Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors.
Topics: Allylestrenol; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Cyproterone Acetate; Flutamide; Humans; Imidazolidines; Male; Models, Molecular; Mutagenesis, Site-Directed; Neoplasms, Hormone-Dependent; Nitriles; Plasmids; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Testosterone; Tosyl Compounds; Transcription, Genetic; Transfection | 2007 |
Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.
Topics: Androgen Receptor Antagonists; Arthritis, Rheumatoid; Cell Culture Techniques; Cell Line, Transformed; Cells, Cultured; Dihydrotestosterone; Flutamide; Genes, Reporter; Humans; Interleukin-1alpha; Luciferases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 2007 |
PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.
Topics: Active Transport, Cell Nucleus; Androgen Receptor Antagonists; Androgens; Carrier Proteins; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Flutamide; Humans; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Nuclear Receptor Coactivator 2; Organ Specificity; Protein Binding; Protein Conformation; Protein-Arginine N-Methyltransferases; Receptors, Androgen; Receptors, Estrogen; Transcriptional Activation; Two-Hybrid System Techniques | 2007 |
Testosterone inhibits matrix metalloproteinase-1 production in human endometrial stromal cells in vitro.
Topics: Adult; Androgen Antagonists; Blotting, Western; Cells, Cultured; Depression, Chemical; Endometrium; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Flutamide; Humans; Matrix Metalloproteinase 1; Medroxyprogesterone Acetate; Progesterone; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells; Testosterone | 2007 |
Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Androgen Antagonists; Biological Transport; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Flutamide; Hepatocytes; Humans; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Microsomes, Liver; Spectrometry, Mass, Electrospray Ionization | 2007 |
A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.
Topics: Androgen Antagonists; Androgens; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Progression; Fluorescent Antibody Technique; Flutamide; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; NF-kappa B; Nitrobenzenes; Polymerase Chain Reaction; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Transfection; Tumor Cells, Cultured; Up-Regulation | 2008 |
Nandrolone decreases mu opioid receptor expression in SH-SY5Y human neuroblastoma cells.
Topics: Androgen Antagonists; Blotting, Western; Cell Line, Tumor; Dactinomycin; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Luciferases; Nandrolone; Neuroblastoma; Nucleic Acid Synthesis Inhibitors; Plasmids; Promoter Regions, Genetic; Receptors, Opioid, mu; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2008 |
Computationally identified novel diphenyl- and phenylpyridine androgen receptor antagonist structures.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Animals; Antineoplastic Agents; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chlorocebus aethiops; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Flutamide; Humans; Male; Models, Molecular; Molecular Structure; Nitriles; Prostatic Neoplasms; Pyridines; Tosyl Compounds | 2008 |
Functional AR signaling is evident in an in vitro mouse follicle culture bioassay that encompasses most stages of folliculogenesis.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Animals; Biological Assay; Cell Culture Techniques; Cells, Cultured; Female; Flutamide; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nitriles; Ovarian Follicle; Receptors, Androgen; Signal Transduction; Tosyl Compounds | 2009 |
Suppression of mutant androgen receptors by flutamide.
Topics: Androgen Antagonists; Androgens; Binding, Competitive; Cell Line, Tumor; Dihydrotestosterone; Flutamide; Humans; Luciferases; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation | 2009 |
Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H.
Topics: Androgen Antagonists; Anilides; Blotting, Western; Cell Line, Tumor; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Humans; Hydrocortisone; Hydrophobic and Hydrophilic Interactions; Male; Mutation; Nitriles; Progesterone; Prostatic Neoplasms; Protein Structure, Secondary; Receptors, Androgen; Steroids; Structure-Activity Relationship; Tosyl Compounds | 2010 |
A mouse model of androgenetic alopecia.
Topics: Alopecia; Androgen Antagonists; Androgens; Animals; beta Catenin; Blotting, Western; Cell Line; Cell Line, Tumor; Dihydrotestosterone; Disease Models, Animal; Female; Flutamide; Hair; Humans; Keratin-5; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Promoter Regions, Genetic; Protein Binding; Receptors, Androgen; Transfection | 2010 |
Is the "comb over" dying? A mouse model for male pattern baldness (androgenic alopecia).
Topics: Alopecia; Androgen Antagonists; Androgens; Animals; beta Catenin; Dihydrotestosterone; Disease Models, Animal; Flutamide; Hair Follicle; Humans; Mice; Mice, Transgenic; Models, Biological; Protein Binding; Receptors, Androgen; Testosterone | 2010 |
Determination of 2-hydroxyflutamide in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS): application to a bioequivalence study on Chinese volunteers.
Topics: Acetonitriles; China; Chromatography, Liquid; Drug Stability; Flutamide; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Tandem Mass Spectrometry; Tegafur; Therapeutic Equivalency | 2010 |
Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species.
Topics: Aniline Compounds; Antineoplastic Agents; Biotransformation; Chromatography, High Pressure Liquid; Cunninghamella; Flutamide; Gas Chromatography-Mass Spectrometry; Humans; Magnetic Resonance Spectroscopy | 2011 |
Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells.
Topics: Androgen Antagonists; Anilides; Antimetabolites, Antineoplastic; Carcinoma; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Flutamide; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Models, Biological; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; Thymidylate Synthase; Tosyl Compounds | 2011 |
QSAR models for anti-androgenic effect--a preliminary study.
Topics: Androgen Antagonists; Animals; CHO Cells; Cricetinae; Cricetulus; Dexamethasone; Flutamide; Humans; Models, Chemical; Quantitative Structure-Activity Relationship; Receptors, Androgen | 2011 |
Androgen receptors in the posterior bed nucleus of the stria terminalis increase neuropeptide expression and the stress-induced activation of the paraventricular nucleus of the hypothalamus.
Topics: Analysis of Variance; Androgen Antagonists; Androgens; Animals; Arginine Vasopressin; Castration; Corticosterone; Dihydrotestosterone; Flutamide; Functional Laterality; Gene Expression Regulation; Glutamate Decarboxylase; Male; Neuropeptides; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Androgen; RNA, Messenger; Septal Nuclei; Stress, Psychological | 2011 |
Androgen receptor coregulators NOCR1, TIF2, and ARA70 may account for the hydroxyflutamide insensitivity of prostate cancer cells.
Topics: Androgen Antagonists; Drug Resistance, Neoplasm; Flutamide; Gene Expression; Gene Expression Profiling; Humans; Male; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 2; Nuclear Receptor Coactivators; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 2011 |
Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines.
Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Base Sequence; Cell Line, Tumor; DNA Primers; Drug Resistance, Neoplasm; Flutamide; Gene Expression Profiling; Humans; Male; Metribolone; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2011 |
A novel steroidal antiandrogen targeting wild type and mutant androgen receptors.
Topics: Androgen Antagonists; Animals; Binding, Competitive; Carbamates; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; Dihydrotestosterone; Drug Screening Assays, Antitumor; Flutamide; Humans; Male; Models, Molecular; Mutation; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Transport; Receptors, Androgen; Structure-Activity Relationship; Transcriptional Activation | 2011 |
Administration of flutamide alters sperm ultrastructure, sperm plasma membrane integrity and its stability, and sperm mitochondrial oxidative capability in the boar: in vivo and in vitro approach.
Topics: Androgen Antagonists; Animals; Cell Membrane; Flutamide; Male; Microscopy, Electron, Transmission; Mitochondria; Oxidation-Reduction; Receptors, Androgen; Spermatozoa; Swine | 2012 |
Androgen receptor signals regulate UDP-glucuronosyltransferases in the urinary bladder: a potential mechanism of androgen-induced bladder carcinogenesis.
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Animals; Cell Line; Cystectomy; Dihydrotestosterone; Down-Regulation; Female; Flutamide; Follow-Up Studies; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Orchiectomy; Receptors, Androgen; Reference Values; Signal Transduction; UDP-Glucuronosyltransferase 1A9; Urinary Bladder; Urinary Bladder Neoplasms | 2013 |
Does 2-hydroxyflutamide inhibit apoptosis in porcine granulosa cells? - An in vitro study.
Topics: Androgen Antagonists; Androgens; Animals; Animals, Inbred Strains; Apoptosis; Cells, Cultured; Down-Regulation; Estradiol; Female; Flutamide; Follicular Atresia; Granulosa Cells; Ovarian Follicle; Progesterone; Receptors, Androgen; Signal Transduction; Sus scrofa; Testosterone; Tissue Culture Techniques; Up-Regulation | 2012 |
Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips.
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Flutamide; Hep G2 Cells; Humans; Lab-On-A-Chip Devices; Liver; Magnetic Resonance Spectroscopy; Metabolomics; Microfluidics | 2013 |
The influence of the antiandrogen 2-hydroxyflutamide on the androgen receptor expression in the porcine ovarian follicles - an in vitro study.
Topics: Androgen Antagonists; Animals; Female; Flutamide; Gene Expression Regulation; Ovarian Follicle; Receptors, Androgen; Swine; Testosterone | 2013 |
Effects of testosterone and 2-hydroxyflutamide on progesterone receptor expression in porcine ovarian follicles in vitro.
Topics: Androgen Antagonists; Androgens; Animals; Blotting, Western; Female; Flutamide; Gene Expression Regulation; Ovarian Follicle; Receptors, Progesterone; Swine; Testosterone | 2012 |
Fluorescence lifetime imaging microscopy for the monitoring of green fluorescent protein-tagged androgen receptors in living cells.
Topics: Animals; Cell Survival; Chlorocebus aethiops; COS Cells; Dihydrotestosterone; Flutamide; Green Fluorescent Proteins; Microscopy, Fluorescence; Receptors, Androgen | 2013 |
Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR.
Topics: Adipocytes; Androgen Receptor Antagonists; Animals; Bone Marrow Cells; Cell Differentiation; Cell Line; ErbB Receptors; Flutamide; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Receptors, Androgen; Signal Transduction | 2013 |
Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression.
Topics: Androgen Antagonists; Androgens; Animals; Cell Differentiation; Cell Line; Flutamide; Follistatin; Mice; Myoblasts; MyoD Protein; Myogenic Regulatory Factor 5; Myogenin; Norpregnadienes; Receptors, Androgen; RNA, Messenger | 2013 |
The impact of antiandrogen 2-hydroxyflutamide on the expression of steroidogenic enzymes in cultured porcine ovarian follicles.
Topics: 3-Hydroxysteroid Dehydrogenases; Androgens; Animals; Aromatase; Estradiol; Female; Flutamide; Gene Expression Regulation; Ovarian Follicle; Progesterone; Receptors, Androgen; RNA, Messenger; Signal Transduction; Steroid 17-alpha-Hydroxylase; Swine; Testosterone; Tissue Culture Techniques | 2014 |
Hydroxyflutamide alters the characteristics of live boar spermatozoa.
Topics: Animals; Flutamide; Male; Membrane Potential, Mitochondrial; Spermatozoa; Superoxides; Swine | 2014 |
Antiandrogens act as selective androgen receptor modulators at the proteome level in prostate cancer cells.
Topics: Amino Acid Sequence; Androgen Antagonists; Anilides; Cell Line, Tumor; Cyproterone Acetate; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Sequence Annotation; Molecular Sequence Data; Mutation; Nandrolone; Neoplasm Proteins; Nitriles; Prostate; Proteome; Receptors, Androgen; Signal Transduction; Tosyl Compounds | 2015 |
Androgens promote the acquisition of maturation competence in bovine oocytes.
Topics: Androgen Receptor Antagonists; Androgens; Animals; Cattle; Cell Nucleus; Dihydrotestosterone; Estradiol; Female; Flutamide; Granulosa Cells; Metaphase; Microscopy, Fluorescence; Oocytes; Receptors, Androgen | 2015 |
Antiandrogen Therapy with Hydroxyflutamide or Androgen Receptor Degradation Enhancer ASC-J9 Enhances BCG Efficacy to Better Suppress Bladder Cancer Progression.
Topics: Androgen Antagonists; Animals; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Cell Line, Tumor; Cell Movement; Cell Survival; Curcumin; Disease Progression; Drug Synergism; Female; Flutamide; Gene Expression; Humans; Integrin alpha5beta1; Interleukin-6; Macrophages; Mice; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome; Urinary Bladder Neoplasms | 2015 |
Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells.
Topics: Androgen Antagonists; Androgens; Animals; Cells, Cultured; Connexin 43; Flutamide; Male; Phosphatidylinositol 3-Kinases; Protein Kinases; Rats, Wistar; Sertoli Cells; Signal Transduction; Testosterone | 2016 |
Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients.
Topics: Androgen Receptor Antagonists; Anilides; Benzamides; DNA; Drug Resistance, Neoplasm; Flutamide; High-Throughput Nucleotide Sequencing; Humans; Male; Mutation; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Tosyl Compounds | 2016 |
Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen.
Topics: Androgen Antagonists; Anilides; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Mutation; Nitriles; Nuclear Receptor Coactivators; Prostatic Neoplasms; Receptors, Androgen; Tosyl Compounds | 2016 |
Enzalutamide inhibits androgen receptor-positive bladder cancer cell growth.
Topics: Androgen Antagonists; Anilides; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dihydrotestosterone; Down-Regulation; Flutamide; Humans; Interleukin-6; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Nitriles; Phenylthiohydantoin; Receptors, Androgen; RNA; Tosyl Compounds; Transcription, Genetic; Urinary Bladder Neoplasms | 2016 |
Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells.
Topics: Adenosine Triphosphate; Culture Media; Flutamide; Galactose; Glucose; Hep G2 Cells; Humans; Mitochondria; NAD; Oxygen Consumption; Superoxides | 2016 |
Primary and tumor mouse Leydig cells exposed to polychlorinated naphthalenes mixture: Effect on estrogen related-receptors expression, intracellular calcium level and sex hormones secretion.
Topics: Animals; Benzodioxoles; Calcium; Cell Line, Tumor; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Flutamide; Gene Expression Regulation; Gonadal Steroid Hormones; Leydig Cells; Male; Mice; Naphthalenes; Quinolines; Receptors, Androgen; Receptors, Estrogen; RNA, Messenger | 2016 |
Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways.
Topics: Androgen Antagonists; Antigens, CD; beta Catenin; Cadherins; Cell Line, Tumor; Flutamide; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptors, Androgen | 2017 |
Pharmacokinetics of the anti-androgenic drug flutamide in healthy stallions.
Topics: Administration, Oral; Androgen Antagonists; Animals; Area Under Curve; Biological Availability; Fasting; Flutamide; Half-Life; Horses; Injections, Intravenous; Male | 2017 |
A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations.
Topics: Androgen Antagonists; Binding Sites; Flutamide; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Protein Binding; Receptors, Androgen | 2017 |
The influence of testosterone on the expression and function of vitamin D(3) receptor (VDR) protein in the porcine ovarian follicle.
Topics: Animals; Female; Flutamide; In Vitro Techniques; Ovarian Follicle; Receptors, Calcitriol; Swine; Testosterone | 2018 |
Androgen Receptor Signaling Reduces Radiosensitivity in Bladder Cancer.
Topics: Androgen Receptor Antagonists; Animals; Cell Line, Tumor; Cell Proliferation; DNA Breaks, Double-Stranded; DNA Repair; Flutamide; Humans; Mice; Radiation Tolerance; Radiation, Ionizing; Receptors, Androgen; Signal Transduction; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2018 |
Structural Dynamics of Agonist and Antagonist Binding to the Androgen Receptor.
Topics: Androgen Receptor Antagonists; Androgens; Anilides; Binding Sites; Dihydrotestosterone; Flutamide; Humans; Molecular Dynamics Simulation; Nitriles; Receptors, Androgen; Testosterone; Tosyl Compounds | 2019 |
Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore.
Topics: Androgen Receptor Antagonists; Androgens; Cell Line, Tumor; Cell Proliferation; Coumarins; Flutamide; Humans; Male; Molecular Structure; Mutation; Nonsteroidal Anti-Androgens; Prostate-Specific Antigen; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen | 2020 |
Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers.
Topics: Adolescent; Adult; Blood Platelets; DNA, Mitochondrial; Female; Flutamide; Genotype; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Tolcapone; Young Adult | 2021 |
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury.
Topics: Chemical and Drug Induced Liver Injury; DNA, Mitochondrial; Flutamide; Genotype; Haplotypes; Humans; Mitochondria; Tolcapone | 2023 |