hydroxyethyl-methacrylate-ethyl-methacrylate and cyclohexene

The aim of this study was to evaluate chlorhexidine release from unfilled non-solvated methacrylate-based resins of increasing hydrophilicity and to examine relationships among Hoy's solubility parameters, water sorption, solubility and the rate of chlorhexidine release.. Resin discs were prepared from light-cured, experimental resin blends (R1, R2, R3, R4 and R5) containing 0.0, 0.2, 1.0 and 2.0 wt.% chlorhexidine diacetate (CDA). Discs were immersed in distilled water at 37 degrees C, and mass changes were recorded at different periods. Spectral measurements were made to follow change in optical densities of storage solution to examine chlorhexidine release kinetics. After a 28-day period, water sorption, solubility, and the cumulative chlorhexidine release were obtained. Additionally, antibacterial study was performed by observing the presence of inhibition zone against Streptococcus mutans.. The most hydrophilic resin (R5) exhibited the highest chlorhexidine release rate. The most hydrophobic resin (R1) exhibited the lowest rate. However, no inhibition zone was produced by any specimens stored in water for 2 weeks. The addition of CDA increased solubility significantly but had no effect on water sorption. Significant positive correlations were seen between water sorption and the cumulative chlorhexidine release.. Chlorhexidine release from resins may be related to water-induced swelling, which in turn is enhanced by the hydrophilicity of cured polymer matrix.

Topics: 4-Aminobenzoic Acid; Absorption; Acrylic Resins; Adsorption; Anti-Infective Agents, Local; Bisphenol A-Glycidyl Methacrylate; Chlorhexidine; Cyclohexenes; Dental Materials; Diffusion; Humans; Hydrophobic and Hydrophilic Interactions; Materials Testing; Methacrylates; para-Aminobenzoates; Polyethylene Glycols; Polyhydroxyethyl Methacrylate; Polymethacrylic Acids; Solubility; Spectrum Analysis; Streptococcus mutans; Temperature; Time Factors; Water; Wettability