hydroxychloroquine and leflunomide

hydroxychloroquine has been researched along with leflunomide in 59 studies

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	22 (37.29)	29.6817
2010's	24 (40.68)	24.3611
2020's	13 (22.03)	2.80

Authors

Authors	Studies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Kremer, JM	1
O'Dell, J	1
Wasko, MC; Wildy, KS	1
Barthel, HR	1
Pisetsky, DS; St Clair, EW	1
Scott, DL	1
Erkan, D; Harrison, MJ; Paget, SA; Yazici, Y	1
Kellner, H; Schiemann, U	1
Gross, WL; Schnabel, A	1
Finesilver, AG	1
Cui, Y; Luo, rQ; Yao, RY; Zhang, X; Zhou, H	1
Chikkamuniyappa, S	1
Emery, P; Suarez-Almazor, M	1
Issa, SN; Ruderman, EM	1
Fath, R	1
Resman-Targoff, BH	1
Allaart, CF; Breedveld, FC; de Vries-Bouwstra, JK; Dijkmans, BA; Gerards, AH; Goekoop-Ruiterman, YP; Hazes, JM; Kerstens, PJ; van der Kooij, SM; van Groenendael, JH; van Zeben, D	1
Matsuda, T; Ohtsubo, H	1
Bingham, CO; Miner, MM	1
Boswell, JS; Costner, MI	1
Brasington, R	1
Díaz, J; González, A; Mora, C; Quintana, G	1
Bambery, P; Jose, V; Mittal, N; Mittal, R; Sharma, A; Wanchu, A	1
Arbogast, PG; Chen, L; Curtis, JR; Delzell, E; Griffin, MR; Grijalva, CG; Herrinton, L; Kawai, VK; Liu, L; Mitchel, EF; Ouellet-Hellstrom, R; Solomon, DH; Stein, CM	1
Miller, AV; Ranatunga, SK	1
Abásolo, L; Fernández-Gutierrez, B; Fontsere, O; Jover-Jover, JA; León, L; Peña-Blanco, RC; Rodriguez-Rodriguez, L	1
Nardi, AE; Ornelas, AC; Pinho de Oliveira Ribeiro, N; Pinho de Oliveira, CM; Rafael de Mello Schier, A; Silva, AC	1
Cleland, LG; Flabouris, K; James, MJ; Lee, AT; Metcalf, RG; Proudman, SM; Rischmueller, M; Spargo, LD; Sullivan, TR; Wechalekar, MD	1
Chen, DY; Chen, HH; Chen, YM; Chou, P; Chou, YJ; Huang, N; Lai, KL; Lin, CH	1
Biswas, M; Chatterjee, S; Ghosh, A; Ghosh, S; Sarkate, P	1
Batat, E; Bitterman, H; Cohen, AD; Cohen, S; Comanesther, D; Feldhamer, I; Greenberg-Dotan, S; Shalom, G; Zisman, D	1
Fautrel, B; Gaujoux-Viala, C; Tsonaka, R; van der Helm-van Mil, AH; van Nies, JA	1
Cortés-Hernández, J; Egri, N; Ordi-Ros, J; Vilardell-Tarrés, M	1
Chen, CJ; Cheng, TT; Lin, JC; Lin, KM	1
Cummins, L; Duggan, E; Katikireddi, VS; Pahau, H; Shankaranarayana, S; Su, KY; Thomas, R; Videm, V	1
Alfaro-Lozano, JL; Elera-Fitzcarrald, C; Pastor-Asurza, CA	1
Horneff, G; Hügle, B	1
Gerosa, M; Meroni, PL; Schioppo, T	1
Chen, DY; Chen, YM; Liao, TL; Liu, HJ	1
Baker, JF; Cannella, A; Cannon, GW; Caplan, L; Davis, LA; England, BR; George, M; Ibrahim, S; Michaud, K; Mikuls, TR; OʼDell, J; Sauer, B; Teng, CC	1
Bazzichi, L; Bianchino, L; Caporali, R; Nacci, F; Sinigaglia, L	1
Bertolo, MB; Brenol, CV; Castelar Pinheiro, GDR; Cruz, BA; de Albuquerque, CP; de Freitas, MVC; Duarte, ALBP; Giorgi, RDN; Gomides, APM; Kakehasi, AM; Laurindo, IMM; Louzada-Júnior, P; Mota, LMHD; Pereira, IA; Ubirajara Silva de Souza, MPG; Xavier, RM	1
Li, RN; Lin, CH; Lin, YZ; Ou, TT; Sung, WY; Tsai, WC; Tseng, CC; Wu, CC; Yen, JH	1
Cai, YM; Gan, YZ; He, J; Li, J; Li, R; Li, SG; Li, ZG; Liao, H; Liu, JJ; Liu, X; Shi, LJ; Sun, XL; Xu, J; Ye, H; Zhang, RJ; Zhao, JX	1
Amiri, N; Baldwin, C; De Vera, MA; Rebić, N; Sayre, EC; Zusman, EZ	1
Bessette, L; Haraoui, B; Lazovskis, J; Pope, J; Rampakakis, E; Sampalis, JS; Vaillancourt, J	1
Li, J; Xie, W; Zhang, Z	1
Cantagrel, A; Combe, B; Daïen, C; Debandt, M; Fautrel, B; Lukas, C; Mary, J; Morel, J	1
Bértolo, MB; Bonfiglioli, KR; Brenol, CV; da Mota, LMH; da Rocha Castelar Pinheiro, G; de Albuquerque, CP; de Fátima Lobato da Cunha Sauma, M; Giorgi, RDN; Gomides, APM; Júnior, PL; Pereira, IA; Radominski, SC; Resende Guimarães, MFB; Santos, ABV	1
Cai, S; Dong, L; Li, M; Sun, W	1
Deng, D; Li, M; Li, S; Tian, L; Wang, T; Wu, J; Yang, J; Zeng, F; Zhou, J; Zou, J	1
Hammad, I; Porter, TF	1
Aga, AB; Bakland, G; Fremstad, H; Haavardsholm, EA; Hansen, IJW; Hansen, IM; Haukeland, H; Høili, CA; Kvien, TK; Lexberg, Å; Lillegraven, S; Ljoså, MA; Madland, TM; Moholt, E; Olsen, IC; Paulshus Sundlisæter, N; Sexton, J; Solomon, DH; Spada, C; Uhlig, T; van der Heijde, D	1
Belani, PJ; Kavadichanda, CG; Negi, VS	1
Filippa, MG; Panopoulos, S; Sfikakis, PP; Spanos, E; Spanos, G; Tektonidou, MG; Yavropoulou, MP	1
Barrett, R; Culliford, D; Edwards, CJ; Fraser, S; Lin, SX	1
Feng, J; Qin, X; Xu, K; Yang, S; Yu, G; Zhang, M; Zheng, P	1
Bekker, CPJ; Blokland, SLM; Hamkour, S; Hillen, MR; Kruize, AA; Leavis, HL; Lopes, AP; Radstake, TR; van der Heijden, EH; Van Helden-Meeuwsen, CG; van Roon, JA; Versnel, MA	1

Reviews

18 review(s) available for hydroxychloroquine and leflunomide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Rational use of new and existing disease-modifying agents in rheumatoid arthritis. Annals of internal medicine, 2001, Apr-17, Volume: 134, Issue:8 Topics: Adjuvants, Immunologic; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Costs; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Risk Factors; Sulfasalazine	2001
Current concepts regarding pharmacologic treatment of rheumatoid and osteoarthritis. Hand clinics, 2001, Volume: 17, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhibitors; Digestive System; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Lactones; Leflunomide; Methotrexate; Osteoarthritis; Pyrazoles; Receptors, Tumor Necrosis Factor; Sulfasalazine; Sulfonamides; Sulfones	2001
Progress in the treatment of rheumatoid arthritis. JAMA, 2001, Dec-12, Volume: 286, Issue:22 Topics: Analgesics; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclosporine; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Penicillamine; Receptors, Tumor Necrosis Factor; Sulfasalazine	2001
Advances in the medical management of rheumatoid arthritis. Hospital medicine (London, England : 1998), 2002, Volume: 63, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Steroids; Sulfasalazine; Treatment Outcome	2002
[Gastrointestinal side effects in the therapy of rheumatologic diseases]. Zeitschrift fur Gastroenterologie, 2002, Volume: 40, Issue:11 Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Etanercept; Gastrointestinal Diseases; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Rheumatic Diseases; Stomach Ulcer; Sulfasalazine; Tumor Necrosis Factor-alpha	2002
Newer approaches to the treatment of rheumatoid arthritis. WMJ : official publication of the State Medical Society of Wisconsin, 2003, Volume: 102, Issue:7 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prednisolone; Receptors, Tumor Necrosis Factor	2003
Rheumatoid arthritis. Clinical evidence, 2003, Issue:9 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Penicillamine; Receptors, Tumor Necrosis Factor; Sulfasalazine	2003
Damage control in rheumatoid arthritis. Hard-hitting, early treatment is crucial to curbing joint destruction. Postgraduate medicine, 2004, Volume: 116, Issue:5 Topics: Arthritis, Rheumatoid; Azathioprine; Disease Progression; Humans; Hydroxychloroquine; Immunologic Factors; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine	2004
Medical therapy: where are we now? American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Sep-15, Volume: 63, Issue:18 Suppl 4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine; Treatment Outcome	2006
[Effective combination therapy of TNF antagonists with DMARDs]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Volume: 65, Issue:7 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cysteine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Tumor Necrosis Factor-alpha	2007
Treatment, management, and monitoring of established rheumatoid arthritis. The Journal of family practice, 2007, Volume: 56, Issue:10 Suppl R Topics: Abatacept; Adalimumab; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Drug Therapy, Combination; Etanercept; Humans; Hydrotherapy; Hydroxychloroquine; Immunoconjugates; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Methotrexate; Physical Therapy Modalities; Primary Health Care; Prognosis; Quality of Life; Receptors, Tumor Necrosis Factor; Rituximab; Severity of Illness Index; Sulfasalazine; Treatment Outcome	2007
Immunotherapies in rheumatologic disorders. The Medical clinics of North America, 2012, Volume: 96, Issue:3 Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Azathioprine; Certolizumab Pegol; Colchicine; Cyclophosphamide; Cyclosporine; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoconjugates; Immunoglobulin Fab Fragments; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Mycophenolic Acid; Polyethylene Glycols; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Rheumatic Diseases; Rituximab; Sulfasalazine; Tumor Necrosis Factor Inhibitors	2012
The role of synthetic drugs in the biologic era: therapeutic strategies for treating juvenile idiopathic arthritis. Expert opinion on pharmacotherapy, 2016, Volume: 17, Issue:5 Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Drug Therapy, Combination; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Quality of Life; Sulfasalazine	2016
Challenges and treatment options for rheumatoid arthritis during pregnancy. Expert opinion on pharmacotherapy, 2016, Volume: 17, Issue:11 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Pregnancy; Pregnancy Complications; Sulfasalazine; Treatment Outcome	2016
A complex COVID-19 case with rheumatoid arthritis treated with tocilizumab. Clinical rheumatology, 2020, Volume: 39, Issue:9 Topics: Aged; Anti-Bacterial Agents; Antifungal Agents; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Aspergillosis; Aspergillus fumigatus; Betacoronavirus; Coronavirus Infections; Cough; COVID-19; Cytokine Release Syndrome; Deprescriptions; Disease Progression; Dyspnea; Female; Glucocorticoids; Humans; Hydroxychloroquine; Immunocompromised Host; Immunosuppressive Agents; Interleukin-6; Leflunomide; Lung; Lymphohistiocytosis, Hemophagocytic; Methylprednisolone; Oxygen Inhalation Therapy; Pandemics; Pneumocystis carinii; Pneumonia, Pneumocystis; Pneumonia, Viral; Pulmonary Aspergillosis; Recurrence; SARS-CoV-2; Tomography, X-Ray Computed	2020
An Update on Biologic Agents During Pregnancy. Clinics in perinatology, 2020, Volume: 47, Issue:4 Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Autoimmune Diseases; Azathioprine; Biological Products; Cyclophosphamide; Cyclosporine; Female; Fetal Growth Retardation; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Leflunomide; Methotrexate; Mycophenolic Acid; Pregnancy; Pregnancy Complications; Premature Birth; Rituximab; Sulfasalazine; Tumor Necrosis Factor Inhibitors	2020
Subacute cutaneous lupus erythematosus as a rare complication of disease-modifying therapy administration in multiple sclerosis: case report. BMC neurology, 2023, Apr-26, Volume: 23, Issue:1 Topics: Adult; Female; Humans; Hydroxychloroquine; Leflunomide; Lupus Erythematosus, Cutaneous; Multiple Sclerosis	2023

Trials

8 trial(s) available for hydroxychloroquine and leflunomide

Article	Year
Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score. Annals of the rheumatic diseases, 2007, Volume: 66, Issue:10 Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Clinical Protocols; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Infliximab; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Sulfasalazine; Treatment Failure; Treatment Outcome	2007
Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use. Annals of the rheumatic diseases, 2015, Volume: 74, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Docosahexaenoic Acids; Double-Blind Method; Drug Therapy, Combination; Early Medical Intervention; Eicosapentaenoic Acid; Female; Fish Oils; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Remission Induction; Sulfasalazine; Treatment Outcome	2015
Subcutaneous tocilizumab alone or with a csDMARD in rheumatoid arthritis patients: subanalysis of Italian data from a multicenter phase IIIb/IV trial. Clinical rheumatology, 2019, Volume: 38, Issue:3 Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Injections, Subcutaneous; Leflunomide; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome	2019
An open-label randomized controlled trial of DMARD withdrawal in RA patients achieving therapeutic response with certolizumab pegol combined with DMARDs. Rheumatology (Oxford, England), 2020, 07-01, Volume: 59, Issue:7 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Deprescriptions; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Sulfasalazine; Tumor Necrosis Factor Inhibitors	2020
Predictors of good response to conventional synthetic DMARDs in early seronegative rheumatoid arthritis: data from the ESPOIR cohort. Arthritis research & therapy, 2019, 11-15, Volume: 21, Issue:1 Topics: Adult; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Leflunomide; Male; Methotrexate; Middle Aged; Prognosis; Rheumatoid Factor; Sulfasalazine; Surveys and Questionnaires; Treatment Outcome	2019
Leflunomide monotherapy versus combination therapy with conventional synthetic disease-modifying antirheumatic drugs for rheumatoid arthritis: a retrospective study. Scientific reports, 2020, 07-23, Volume: 10, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies	2020
Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial. JAMA, 2021, 05-04, Volume: 325, Issue:17 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Sulfasalazine; Symptom Flare Up; Ultrasonography	2021
Comparison between leflunomide and sulfasalazine based triple therapy in methotrexate refractory rheumatoid arthritis: an open-label, non-inferiority randomized controlled trial. Rheumatology international, 2022, Volume: 42, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Leflunomide; Methotrexate; Sulfasalazine; Treatment Outcome	2022

Other Studies

33 other study(ies) available for hydroxychloroquine and leflunomide

Article	Year
Conventional DMARD options for patients with a suboptimal response to methotrexate. The Journal of rheumatology. Supplement, 2001, Volume: 62 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Sulfasalazine	2001
Leflunomide for the treatment of systemic lupus erythematosus: comment on the article by McMurray. Arthritis and rheumatism, 2001, Volume: 45, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Methotrexate; Middle Aged; Prednisolone	2001
Physician treatment preferences in rheumatoid arthritis of differing disease severity and activity: the impact of cost on first-line therapy. Arthritis and rheumatism, 2002, Jun-15, Volume: 47, Issue:3 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Costs and Cost Analysis; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Pilot Projects; Practice Patterns, Physicians'; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Surveys and Questionnaires; Tumor Necrosis Factor-alpha	2002
[Evidence-based treatment of methotrexate-resistant rheumatoid arthritis. Combinations of conventional disease-modifying antirheumatic agents]. Deutsche medizinische Wochenschrift (1946), 2003, Jan-24, Volume: 128, Issue:4 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Placebos; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine; Time Factors	2003
[Methotrexate combined with leflunomide or hydroxychloroquine in the treatment of rheumatoid arteritis]. Zhonghua yi xue za zhi, 2004, Jun-17, Volume: 84, Issue:12 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged	2004
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. Dermatology online journal, 2004, Jul-15, Volume: 10, Issue:1 Topics: Accidental Falls; Adrenal Cortex Hormones; Aged; Amputation, Surgical; Anti-Bacterial Agents; Antirheumatic Agents; Arm; Arthritis, Rheumatoid; Cellulitis; Combined Modality Therapy; Debridement; Diagnosis, Differential; Drug Therapy, Combination; Elbow Injuries; Fasciitis, Necrotizing; Humans; Hydroxychloroquine; Immunocompromised Host; Isoxazoles; Leflunomide; Male; Shock, Septic; Staphylococcal Scalded Skin Syndrome; Streptococcus pyogenes	2004
[When to begin rheumatism treatment? Initial combination therapy helps fastest]. MMW Fortschritte der Medizin, 2004, Sep-09, Volume: 146, Issue:37 Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydroxychloroquine; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2004
Leflunomide as adjuvant treatment of dermatomyositis. Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:3 Topics: Adjuvants, Immunologic; Adult; Aged; Dermatologic Agents; Dermatomyositis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Treatment Outcome	2008
Disease-modifying antirheumatic drugs. The Journal of hand surgery, 2009, Volume: 34, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine	2009
[Financial cost of early rheumatoid arthritis in the first year of medical attention: three clinical scenarios in a third-tier university hospital in Colombia]. Biomedica : revista del Instituto Nacional de Salud, 2009, Volume: 29, Issue:1 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Colombia; Diagnostic Services; Direct Service Costs; Disease Management; Drug Costs; Drug Therapy, Combination; Etanercept; Health Care Costs; Hospital Costs; Hospitals, University; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Thiazines; Thiazoles	2009
Causes of DMARD withdrawal following ADR within 6 months of initiation among Indian rheumatoid arthritis patients. Rheumatology international, 2012, Volume: 32, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxychloroquine; India; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Time Factors	2012
Changes in cotherapies after initiation of disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis. Arthritis care & research, 2011, Volume: 63, Issue:10 Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Narcotics; Retrospective Studies; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2011
Leflunomide discontinuation in rheumatoid arthritis and influence of associated disease-modifying anti-rheumatic drugs: a survival analysis. Scandinavian journal of rheumatology, 2013, Volume: 42, Issue:6 Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Longitudinal Studies; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome; Withholding Treatment	2013
Anxiety, depression and suicidal ideation in patients with rheumatoid arthritis in use of methotrexate, hydroxychloroquine, leflunomide and biological drugs. Comprehensive psychiatry, 2013, Volume: 54, Issue:8 Topics: Adult; Aged; Antirheumatic Agents; Anxiety; Arthritis, Rheumatoid; Comorbidity; Depression; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Psychiatric Status Rating Scales; Suicidal Ideation	2013
Periodontitis and etanercept discontinuation risk in anti-tumor necrosis factor-naive rheumatoid arthritis patients: a nationwide population-based cohort study. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2013, Volume: 19, Issue:8 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Periodontitis; Receptors, Tumor Necrosis Factor; Retrospective Studies; Risk Assessment; Risk Factors; Sulfasalazine; Tumor Necrosis Factor-alpha	2013
Early, structured disease modifying anti-rheumatic drug (DMARD) therapy reduces cardiovascular risk in rheumatoid arthritis--a single centre study using non-biologic drugs. The Journal of the Association of Physicians of India, 2013, Volume: 61, Issue:8 Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cholesterol; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Methylprednisolone; Middle Aged; Severity of Illness Index; Sulfasalazine; Triglycerides; Young Adult	2013
Psoriatic arthritis treatment and the risk of herpes zoster. Annals of the rheumatic diseases, 2016, Volume: 75, Issue:1 Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Azathioprine; Cyclosporine; Drug Combinations; Drug Therapy, Combination; Etanercept; Female; Glucosamine; Herpes Zoster; Humans; Hydroxychloroquine; Incidence; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Tumor Necrosis Factor-alpha	2016
Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts. Annals of the rheumatic diseases, 2015, Volume: 74, Issue:5 Topics: Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Autoantibodies; Cohort Studies; Disease Progression; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Proportional Hazards Models; Remission Induction; Sulfasalazine; Time-to-Treatment; Treatment Outcome	2015
Etanercept in refractory lupus arthritis: An observational study. Seminars in arthritis and rheumatism, 2015, Volume: 44, Issue:6 Topics: Adult; Antirheumatic Agents; Arthritis; Autoantibodies; Cohort Studies; Etanercept; Female; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Treatment Outcome	2015
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study. Clinical rheumatology, 2015, Volume: 34, Issue:6 Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies; Cyclosporine; Drug Therapy, Combination; Etanercept; Female; Hepatitis C, Chronic; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha	2015
Safety and retention of combination triple disease-modifying anti-rheumatic drugs in new-onset rheumatoid arthritis. Internal medicine journal, 2015, Volume: 45, Issue:12 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Sulfasalazine; Treatment Outcome; United States	2015
Garre's sclerosing osteomyelitis caused by salmonella group D in a patient with systemic lupus erythematosus: an unusual complication. Clinical rheumatology, 2015, Volume: 34, Issue:12 Topics: Adult; Anti-Bacterial Agents; Antiphospholipid Syndrome; Ceftazidime; Doxycycline; Femur; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Male; Methotrexate; Osteomyelitis; Prednisone; Salmonella Infections; Sclerosis; Trimethoprim, Sulfamethoxazole Drug Combination	2015
Risk and severity of herpes zoster in patients with rheumatoid arthritis receiving different immunosuppressive medications: a case-control study in Asia. BMJ open, 2017, 01-05, Volume: 7, Issue:1 Topics: Abatacept; Adalimumab; Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Case-Control Studies; Etanercept; Female; Herpes Zoster; Herpes Zoster Ophthalmicus; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Odds Ratio; Risk Factors; Rituximab; Severity of Illness Index; Sulfasalazine; Taiwan; Time Factors; Tumor Necrosis Factor-alpha; Young Adult	2017
Initiation of Disease-Modifying Therapies in Rheumatoid Arthritis Is Associated With Changes in Blood Pressure. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2018, Volume: 24, Issue:4 Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Pressure; Female; Humans; Hydroxychloroquine; Hypertension; Incidence; Leflunomide; Linear Models; Male; Methotrexate; Middle Aged; Prednisone; Retrospective Studies; Sulfasalazine; Tumor Necrosis Factor Inhibitors	2018
2017 recommendations of the Brazilian Society of Rheumatology for the pharmacological treatment of rheumatoid arthritis. Advances in rheumatology (London, England), 2018, May-24, Volume: 58, Issue:1 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Brazil; Decision Making; Drug Substitution; Drug Therapy, Combination; Glucocorticoids; Humans; Hydroxychloroquine; Leflunomide; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Rheumatology; Societies, Medical; Sulfasalazine	2018
Genetic and epigenetic alteration of the programmed cell death 1 in rheumatoid arthritis. European journal of clinical investigation, 2019, Volume: 49, Issue:10 Topics: Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Odds Ratio; Polymorphism, Single Nucleotide; Programmed Cell Death 1 Receptor; Reverse Transcriptase Polymerase Chain Reaction; Rheumatoid Factor; RNA, Messenger; Sulfasalazine; Transcriptome; Treatment Failure; Treatment Outcome	2019
Clinical deep remission and related factors in a large cohort of patients with rheumatoid arthritis. Chinese medical journal, 2019, May-05, Volume: 132, Issue:9 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Surveys and Questionnaires	2019
Perinatal use and discontinuation of disease-modifying anti-rheumatic drugs and biologics in women with rheumatoid arthritis: a cohort study. Rheumatology (Oxford, England), 2020, 07-01, Volume: 59, Issue:7 Topics: Abatacept; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Biological Products; British Columbia; Chloroquine; Cohort Studies; Cyclophosphamide; Cyclosporine; Deprescriptions; Female; Glucocorticoids; Gold Compounds; Humans; Hydroxychloroquine; Interleukin 1 Receptor Antagonist Protein; Leflunomide; Logistic Models; Maternal Age; Methotrexate; Mycophenolic Acid; Odds Ratio; Preconception Care; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, First; Rheumatology; Rituximab; Sulfasalazine; Tumor Necrosis Factor Inhibitors	2020
The impact of different criteria sets on early remission and identifying its predictors in rheumatoid arthritis: results from an observational cohort (2009-2018). Clinical rheumatology, 2020, Volume: 39, Issue:2 Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; China; Cohort Studies; Female; Glucocorticoids; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Patient Reported Outcome Measures; Remission Induction; Retrospective Studies; Sex Factors; Sulfasalazine	2020
Rheumatoid artrhitis treatment in Brazil: data from a large real-life multicenter study. Advances in rheumatology (London, England), 2020, 02-27, Volume: 60, Issue:1 Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Brazil; Chi-Square Distribution; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Statistics, Nonparametric; Sulfasalazine	2020
Impaired adrenal cortex reserve in patients with rheumatic and musculoskeletal diseases who relapse upon tapering of low glucocorticoid dose. Clinical and experimental rheumatology, 2022, Volume: 40, Issue:9 Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Insufficiency; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Cosyntropin; Glucocorticoids; Humans; Hydrocortisone; Hydroxychloroquine; Leflunomide; Methotrexate; Prednisolone; Recurrence; Tumor Necrosis Factor Inhibitors	2022
Impact of the COVID-19 pandemic on prescription refills for immune-mediated inflammatory disorders: a time series analysis (January 2019 to January 2021) using the English Prescribing Dataset. BMJ open, 2022, 12-23, Volume: 12, Issue:12 Topics: Azathioprine; Communicable Disease Control; COVID-19; Drug Prescriptions; Humans; Hydroxychloroquine; Leflunomide; Methotrexate; Pandemics; Sulfasalazine; Time Factors	2022
Leflunomide/hydroxychloroquine combination therapy targets type I IFN-associated proteins in patients with Sjögren's syndrome that show potential to predict and monitor clinical response. RMD open, 2023, Volume: 9, Issue:3 Topics: Biomarkers; Humans; Hydroxychloroquine; Interferon Type I; Leflunomide; Leukocytes, Mononuclear; Proteins; RNA; Sjogren's Syndrome	2023