hydroquinone has been researched along with benzene in 153 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (15.03) | 18.7374 |
| 1990's | 54 (35.29) | 18.2507 |
| 2000's | 40 (26.14) | 29.6817 |
| 2010's | 28 (18.30) | 24.3611 |
| 2020's | 8 (5.23) | 2.80 |
| Authors | Studies |
|---|---|
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Abellán Guillén, A; Cordeiro, MN; Garrido Escudero, A; Morales Helguera, A; Pérez-Garrido, A | 1 |
| Fujie, K; Ito, Y; Maeda, S | 1 |
| Ganousis, LG; Goon, D; Ross, D; Wu, KK; Zyglewska, T | 1 |
| Neun, DJ; Penn, A; Snyder, CA | 2 |
| Schad, H; Schäfer, F; Seidel, HJ; Weber, L | 1 |
| Kolachana, P; Smith, MT; Subrahmanyam, VV | 1 |
| Kalf, GF; Renz, JF | 1 |
| Kalf, G; Renz, J; Schlosser, M; Shurina, R | 1 |
| Bois, FY; Smith, MT; Spear, RC | 1 |
| Hedli, CC; Snyder, R; Witmer, CM | 1 |
| Eastmond, DA; Robertson, ML; Smith, MT; Yager, JW | 1 |
| Eastmond, DA; Paradisin, WM; Robertson, ML; Smith, MT; Yager, JW | 1 |
| Cooper, KR; Dimitriadis, EA; Guy, RL; Hu, PD; Snyder, R | 1 |
| Doane-Setzer, P; Ross, D; Smith, MT; Steinmetz, KL; Subrahmanyam, VV | 1 |
| Kalf, GF; Post, GB; Snyder, R | 1 |
| Fan, XH; Hirata, Y; Minami, M | 1 |
| Reasor, MJ; Thomas, DJ; Wierda, D | 1 |
| Koop, DR; Laethem, CL; Schnier, GG | 1 |
| Bauer, H; Cooper, K; Dimitriadis, E; Goldstein, BD; Guy, R; Hu, P; Snyder, R; Witz, G | 1 |
| Adams, DO; Lewis, JG; Stewart, W | 1 |
| Garner, CD; Johnson, JT; Lee, EW | 1 |
| Haga, S; Koike, N; Sakurai, M; Sato, A; Shimizu, H; Ubukata, N | 1 |
| Gaido, KW; Wierda, D | 1 |
| Abraham, NG; Brown, A; Levere, RD; Lutton, JD; Nelson, J | 1 |
| Cai, SX; Ikeda, M; Inoue, O; Jin, C; Kasahara, M; Li, GL; Nakatsuka, H; Seiji, K; Watanabe, T; Yin, SG | 1 |
| King, AG; Landreth, KS; Wierda, D | 1 |
| Jowa, L; Kalf, G; Rushmore, T; Snyder, R; Witz, G | 1 |
| Blumer, JL; Pellack-Walker, P | 1 |
| Gad-El Karim, MM; Legator, MS; Sadagopa Ramanujam, VM | 1 |
| Ahmed, AE; Gad-el-Karim, MM; Legator, MS; Ramanujam, VM | 1 |
| Kalf, G; Rushmore, T; Snyder, R | 1 |
| Gaido, K; Wierda, D | 1 |
| Kissinger, PT; Lunte, SM | 1 |
| Ahmad, S; Rao, GS; Singh, V | 1 |
| Eastmond, DA; Hasegawa, LS; Rupa, DS | 1 |
| Barale, R; Barrai, I; Chelotti, L; Loprieno, N; Marrazzini, A | 1 |
| Carbonnelle, P; Lauwerys, R; Leroy, JY; Lison, D | 1 |
| Hazel, BA; Kalf, GF; Niculescu, R; O'Connor, A | 2 |
| Chen, H; Eastmond, DA | 1 |
| Li, Y; Trush, MA; Zhu, H | 1 |
| Medinsky, MA; Schlosser, P; Seaton, MJ | 1 |
| Bond, JA; Medinsky, MA; Schlosser, PM | 1 |
| Kuppusamy, P; Li, Y; Trush, MA; Zweier, JL | 1 |
| Birnbaum, LS; McMahon, TF; Medinsky, MA | 1 |
| Laskin, DL; Laskin, JD; Punjabi, CJ; Rao, NR; Synder, R | 1 |
| Chapman, DE; Juchau, MR; Namkung, MJ | 1 |
| Kalf, GF; O'Connor, A | 1 |
| Chepiga, T; Oesch, F; Platt, K; Snyder, R; Thomas, H; Yang, CS | 1 |
| Lee, BL; Ong, CN; Ong, HY; Shi, CY | 1 |
| Hoener, BA; Legathe, A; Tozer, TN | 1 |
| Bodell, WJ; Levay, G; Pongracz, K | 1 |
| Kolachana, P; Meyer, KB; Smith, MT; Subrahmanyam, VV; Zhang, L | 1 |
| Bradford, HN; Colman, RW; Kalf, GF; Niculescu, R | 1 |
| Hudson, KT; Kenyon, EM; Kraichely, RE; Medinsky, MA | 1 |
| Carlson, GP; Chaney, AM | 1 |
| Kenyon, EM; Medinsky, MA; Schlosser, PM | 1 |
| Kalf, GF; Niculescu, R; Renz, JF | 1 |
| Moran, JL; Ross, D; Siegel, D; Sun, XM | 1 |
| Hazel, BA; Kalf, GF | 1 |
| Gut, I; Nedelcheva, V; Soucek, P; Stopka, P; Tichavská, B | 1 |
| Li, Y; Rembish, SJ; Trush, MA; Twerdok, LE; Zhu, H | 1 |
| Irons, RD; Stillman, WS | 1 |
| Hutt, AM; Kalf, GF | 1 |
| Glatt, HR; Henschler, R; Heyworth, CM | 1 |
| Andreoli, C; Crebelli, R; Leopardi, P | 1 |
| Buchet, JP; Carbonnelle, P; Haufroid, V; Hotz, P; Lauwerys, R; Tschopp, A | 1 |
| Bratton, SB; Lau, SS; Monks, TJ | 1 |
| Irons, RD; Pyatt, DW; Stillman, WS | 1 |
| Asgharian, B; Himmelstein, MW; Kenyon, EM; Medinsky, MA; Seaton, MJ | 1 |
| Smith, MT; Wiemels, J | 1 |
| Moran, JL; Ross, D; Siegel, D | 1 |
| Catania, S; Costa, C; Imperatore, C; Pupo, C; Salemi, M; Viscomi, G | 1 |
| Irons, RD; Stillman, WS; Varella-Garcia, M | 1 |
| Chen, L; Cohen, B; Jin, X; Kagan, MR; Li, G; Li, H; Li, K; Li, Y; Melikian, AA; Meng, M; Mu, R; Qu, Q; Shore, R; Winnik, W; Yin, S | 1 |
| Kalf, GF | 1 |
| De Bartolomeo, A; Fabiani, R; Lepore, L; Morozzi, G; Rosignoli, P; Scamosci, M | 1 |
| Draths, KM; Frost, JW; Knop, DR; Ran, N | 1 |
| Carlson, GP; Powley, MW | 1 |
| Gut, I; Soucek, P | 1 |
| Hazel, BA; Hoffmann, MJ; Kalf, GF; Kim, DD; Snyder, R | 1 |
| Fujii-Kuriyama, Y; Hirabayashi, Y; Inoue, T; Kaneko, T; Kanno, J; Kawasaki, Y; Kim, DY; Kodama, Y; Yoon, BI | 1 |
| Winn, LM | 1 |
| Bois, FY; Cicolella, A; Dujardin, R; Gehanno, JF; Gonzalez-Flesca, N; Kouniali, A | 1 |
| Mohan, K; Park, S; Pyo, H; Weisel, CP; Witz, G | 1 |
| Mori, T; Morisawa, S; Nakayama, A; Noguchi, Y; Yagi, T | 1 |
| Goto, R; Ibuki, Y | 1 |
| Farmer, PB; Gaskell, M; McLuckie, KI | 2 |
| Hubbard, AE; Smith, MT; Yang, W; Zhang, L | 1 |
| Angelucci, M; Fatigoni, C; Monarca, S; Moretti, M; Pasquini, R; Scassellati-Sforzolini, G; Simonucci, S; Strappini, M; Villarini, M | 1 |
| Kang, BY; Kim, E; Kim, TS | 1 |
| Eastmond, DA; Hasegawa, L; Mondrala, ST | 1 |
| Rivedal, E; Witz, G | 1 |
| Dimitrova, ND; Kostadinova, RY; Marinova, SN; Panev, TI; Popov, TA | 1 |
| Johnson, BA; Kim, S; Lan, Q; Li, G; Rappaport, SM; Rothman, N; Shen, M; Smith, MT; Vermeulen, R; Waidyanatha, S; Yin, S; Zhang, L | 1 |
| Badham, HJ; Winn, LM | 2 |
| Grimes, P; Nordlund, J; Ortonne, JP | 1 |
| Kondrová, E; Soucek, P; Stopka, P | 1 |
| Cho, JY; Chun, T; Kim, JY; Lee, JY; Lee, YG; Rhee, MH; Shin, WC | 1 |
| Hatzi, VI; Makropoulos, V; Pantelias, GE; Spiliopoulou, C; Terzoudi, GI | 1 |
| Arbieva, Z; Gavin, IM; Gillis, B; Jayaraman, S; King, ST; Prabhakar, BS | 1 |
| Wan, J; Winn, LM | 1 |
| Galván, N; Lim, S; Smith, MT; Zhang, L; Zmugg, S | 1 |
| Snyder, R | 1 |
| Lautens, M; Raemy, M; Rudolph, A; Thansandote, P | 1 |
| PORTEOUS, JW; WILLIAMS, RT | 2 |
| GARTON, GA; WILLIAMS, RT | 1 |
| SOLLMANN, T | 1 |
| Ibuki, Y; Ishihama, M; Toyooka, T | 1 |
| Cho, JY | 1 |
| Azizi, SN; Chaichi, MJ; Yousefi, M | 1 |
| Guo, W; Ji, Z; McHale, CM; Smith, MT; Zhang, L | 1 |
| Hiraki, Y; Kepa, JK; Miura, S; Ross, D; Siegel, D; Zhou, H | 1 |
| Chan, KM; Ibrahim, HA; Inayat-Hussain, SH; Rajab, NF; Ross, D; Siew, EL | 1 |
| Fu, H; Irons, RD; Kerzic, PJ; Liu, WS; Pan, MT; Schnatter, AR; Zhou, Y | 1 |
| Kim, S; Lan, Q; Li, G; Rappaport, SM; Rothman, N; Smith, MT; Vermeulen, R; Waidyanatha, S; Yin, S; Zhang, L | 1 |
| Eastmond, DA; Mondrala, S | 1 |
| Bratton, SB; Kuhlman, CL; Lau, SS; Monks, TJ | 1 |
| Butterworth, M; Lau, SS; Monks, TJ | 1 |
| Cho, JY; Cho, WJ; Kim, AR; Kim, JY; Kim, S; Lee, J; Lee, JY; Lee, YG; Park, J; Won, MH; Yang, KJ; Yoo, BC | 1 |
| Arnold, SM; Dryzga, MD; Price, PS | 1 |
| Shiga, T; Suzuki, H; Yamamoto, A; Yamamoto, H; Yamamoto, K | 1 |
| Han, QL; Li, XF; Wang, J; Wang, Y; Wu, XR; Xue, M; Yi, ZC | 1 |
| Chen, DZ; Chen, JM; Zhou, YY; Zhu, RY | 1 |
| Brautbar, N; Regev, L; Wu, M; Zlotolow, R | 1 |
| Chunhui, H; Jiaxing, W; Peng, D; Weiyi, P; Xiaomin, W | 1 |
| Kim, IS; Lee, JS; Yang, EJ | 1 |
| Amirizadeh, N; Hosseinkhani, S; Nazem, S; Sadeghizadeh, M; Zolghadr, F | 1 |
| Bi, Y; Guo, L; Huang, W; Li, Z; Ma, Q; Wang, H; Wang, L; Wang, S; Wang, W; Yang, S; Yang, T; Zhu, J | 1 |
| Hu, K; Jiang, H; Lai, Y; Liu, Y; Wei, Q | 1 |
| Anastasio, C; Kinney, H; Smith, JD | 1 |
| Abdollahi, M; Baeeri, M; Bahadar, H; Ghafour-Boroujerdi, E; Gholami, M; Maqbool, F; Mostafalou, S | 1 |
| Chen, W; Chen, Y; Deng, N; Deng, Q; Huang, M; Liang, B; Liu, L; Liu, X; Ma, X; Qin, F; Tang, H; Xiao, Y; Yuan, W; Zhang, B; Zhang, Q; Zhang, X | 1 |
| Chen, H; Hou, H; Hu, Q; Liu, Y; Wang, A; Zhang, S | 1 |
| Banton, M; Boogaard, PJ; Cox, LA; Ketelslegers, HB; Schnatter, AR | 1 |
| Chen, J; Chen, Y; Han, Y; Jiang, S; Li, J; Ma, R; Qian, S; Shi, Y; Yu, K; Zhang, S | 1 |
| Jones, K; Loizou, GD; McNally, K; Sams, C | 1 |
| Chen, Y; Han, Y; Jiang, S; Qian, S; Shi, Y; Xu, W; Yang, Y; Yu, K; Yu, Z; Zhang, S; Zhu, Y | 1 |
| Li, A; Ma, L; Reetz, MT; Wang, B; Wang, F; Yu, X; Zhou, H | 1 |
| He, F; Hou, F; Lu, Y; Wang, QF; Xing, C; Xu, P; Yang, X | 1 |
| Ling, X; Liu, L; Pan, Z; Tan, Q; Wu, M; Xie, D; Xie, P; Yuan, Q; Zhang, H; Zheng, D | 1 |
| Chen, J; Chen, X; Huang, D; Li, H; Ling, X; Liu, L; Pan, Z; Tan, Q; Zhang, H; Zheng, D; Zhong, B | 1 |
| Chen, J; Gui, Z; Huang, D; Ling, X; Liu, L; Liu, Z; Pan, Z; Peng, J; Tan, Q; Wu, M; Xiu, L; Yuan, Q; Zhang, H | 1 |
| Dong, S; He, J; Jia, Q; Li, C; Li, M; Peng, C; Shao, H; Xing, C; Yang, X | 1 |
| Chen, Y; Li, B; Tang, H; Wang, H; Wu, H; Wu, Y; Yang, H; Ye, Z | 1 |
| Cheng, X; Li, J; Lian, N; Lu, Y; Sui, P; Wang, QF; Xing, C; Xu, P; Zhou, J | 1 |
| Chen, X; Han, Y; Jiang, F; Ling, X; Liu, L; Meng, J; Pan, Z; Yuan, Q; Zhang, H; Zheng, D; Zhong, B; Zhong, Q | 1 |
| Rong, L; Yang, SQ; Yi, ZC; Yu, CH; Zhang, YJ | 1 |
6 review(s) available for hydroquinone and benzene
| Article | Year |
|---|---|
The role of hepatic metabolites of benzene in bone marrow peroxidase-mediated myelo- and genotoxicity.
Topics: Animals; Benzene; Benzoquinones; Biotransformation; Bone Marrow; Humans; Hydroquinones; Mutagens; Peroxidases; Phenol; Phenols; Prostaglandin-Endoperoxide Synthases | 1991 |
Role of metabolism in benzene-induced myelotoxicity and leukemogenesis.
Topics: Animals; Benzene; Biotransformation; Bone Marrow; Catechols; Cells, Cultured; Cytochrome P-450 Enzyme System; Humans; Hydroquinones; Leukemia; Liver; Mutagenicity Tests; Oxygenases; Peroxidases; Phenol; Phenols; T-Lymphocytes | 1990 |
The effects of benzene and hydroquinone on myeloid differentiation of HL-60 promyelocytic leukemia cells.
Topics: Arachidonate 5-Lipoxygenase; Benzene; Cell Differentiation; Enzyme Activation; Granulocytes; Humans; Hydroquinones; Leukemia, Promyelocytic, Acute; Protein Kinase C | 1993 |
Benzene-induced bone marrow cell depression caused by inhibition of the conversion of pre-interleukins-1alpha and -1beta to active cytokines by hydroquinone, a biological reactive metabolite of benzene.
Topics: Animals; Benzene; Biotransformation; Bone Marrow; Bone Marrow Cells; Carcinogens; Cytokines; Humans; Hydroquinones; Interleukin-1; Mutagens | 1996 |
Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced hematotoxicities.
Topics: Animals; Benzene; Bone Marrow; Bone Marrow Cells; Cytochrome P-450 CYP2E1; Drug Resistance; Glutathione; Humans; Hydroquinones; Liver; Mice; NAD(P)H Dehydrogenase (Quinone); Rats; Thiones; Thiophenes | 1996 |
Hydroquinone, a benzene metabolite, and leukemia: a case report and review of the literature.
Topics: Adult; Animals; Benzene; Chromosome Aberrations; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 7; Humans; Hydroquinones; Leukemia, Myeloid, Acute; Male; Mice; Mutagens; Myelodysplastic Syndromes; Occupational Diseases; Occupational Exposure; Rats | 2012 |
147 other study(ies) available for hydroquinone and benzene
| Article | Year |
|---|---|
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.
Topics: beta-Cyclodextrins; Hydrophobic and Hydrophilic Interactions; Organic Chemicals; Quantitative Structure-Activity Relationship | 2009 |
Acute cytogenetic effect of benzene on rat bone marrow cells in vivo and the effect of inducers or inhibitors of drug-metabolizing enzymes.
Topics: Animals; Azo Compounds; Benzene; Benzoquinones; Bone Marrow; Bone Marrow Cells; Chi-Square Distribution; Chromosome Aberrations; Cyclohexanes; Cyclohexenes; Female; Hydroquinones; Male; Mutagenicity Tests; Mutagens; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Rats, Wistar; Sex Factors; Species Specificity | 1992 |
Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites.
Topics: Aged; Animals; Arylsulfatases; Benzene; Biotransformation; Bone Marrow; Bone Marrow Cells; Fibroblasts; Glucuronosyltransferase; Glutathione; Humans; Hydroquinones; Inactivation, Metabolic; Macrophages; Male; Mice; NAD(P)H Dehydrogenase (Quinone); Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Stromal Cells | 1992 |
Evidence for strain-specific differences in benzene toxicity as a function of host target cell susceptibility.
Topics: Animals; Benzene; Benzoquinones; Bone Marrow; Catechols; Hematopoietic Stem Cells; Hydroquinones; Male; Mice; Mice, Inbred Strains; Species Specificity | 1992 |
Determination of benzene metabolites in urine of mice by solid-phase extraction and high-performance liquid chromatography.
Topics: Animals; Benzene; Catechols; Chromatography, High Pressure Liquid; Female; Hydroquinones; Mice; Phenol; Phenols; Sorbic Acid; Spectrophotometry, Ultraviolet | 1992 |
Hydroxylation of phenol to hydroquinone catalyzed by a human myeloperoxidase-superoxide complex: possible implications in benzene-induced myelotoxicity.
Topics: Benzene; Hematologic Diseases; Histidine; Humans; Hydroquinones; Hydroxylation; Mannitol; Neutrophils; Peroxidase; Phenol; Phenols; Superoxide Dismutase; Superoxides | 1991 |
Role for interleukin-1 (IL-1) in benzene-induced hematotoxicity: inhibition of conversion of pre-IL-1 alpha to mature cytokine in murine macrophages by hydroquinone and prevention of benzene-induced hematotoxicity in mice by IL-1 alpha.
Topics: Animals; Benzene; Blotting, Western; Bone Marrow Cells; Cells, Cultured; DNA; Hematologic Diseases; Hydroquinones; Indomethacin; Interleukin-1; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Protein Biosynthesis; Protein Precursors; Recombinant Proteins | 1991 |
Mechanisms of benzene carcinogenesis: application of a physiological model of benzene pharmacokinetics and metabolism.
Topics: Administration, Inhalation; Animals; Benzene; Calibration; Hydroquinones; Liver; Lung; Male; Models, Biological; Monte Carlo Method; Neoplasms, Experimental; Phenols; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1991 |
Bone marrow DNA adducts and bone marrow cellularity following treatment with benzene metabolites in vivo.
Topics: Animals; Benzene; Bone Marrow; DNA; Hydroquinones; Male; Phenol; Phenols; Rats; Rats, Inbred Strains | 1991 |
Characterization of micronuclei induced in human lymphocytes by benzene metabolites.
Topics: Adult; Benzene; Benzoquinones; Catechols; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Hydroquinones; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Phenol; Phenols; Quinones | 1990 |
Interactive inhibition of erythroid 59Fe utilization by benzene metabolites in female mice.
Topics: Animals; Benzene; Catechols; Erythrocytes; Erythropoiesis; Female; Hemoglobins; Hydroquinones; Iron; Iron Radioisotopes; Male; Mice; Phenol; Phenols; Reference Values | 1990 |
Phenol-induced stimulation of hydroquinone bioactivation in mouse bone marrow in vivo: possible implications in benzene myelotoxicity.
Topics: Animals; Benzene; Biotransformation; Bone Marrow; Bone Marrow Diseases; Catechols; Hydroquinones; Injections, Intraperitoneal; Kidney; Liver; Mice; Oxidation-Reduction; Phenols | 1990 |
Inhibition of RNA synthesis and interleukin-2 production in lymphocytes in vitro by benzene and its metabolites, hydroquinone and p-benzoquinone.
Topics: Animals; Benzene; Benzoquinones; Dose-Response Relationship, Drug; Hydroquinones; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Lymphocytes; Male; Mice; Quinones; RNA | 1985 |
Effect of benzene and its metabolites on natural killer activity of mouse spleen cells in vitro.
Topics: Animals; Benzene; Depression, Chemical; Hydroquinones; In Vitro Techniques; Killer Cells, Natural; Male; Mice; Mice, Inbred C57BL; Phenol; Phenols; Spleen | 1989 |
Macrophage regulation of myelopoiesis is altered by exposure to the benzene metabolite hydroquinone.
Topics: Animals; Benzene; Bone Marrow; Bone Marrow Cells; Cell Line; Colony-Stimulating Factors; Hematopoiesis; Hematopoietic Stem Cells; Hydroquinones; Interleukin-1; Macrophages; Male; Mice; Mice, Inbred C3H | 1989 |
Identification of ethanol-inducible P450 isozyme 3a (P450IIE1) as a benzene and phenol hydroxylase.
Topics: Animals; Benzene; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Hydroquinones; Immunoglobulin G; Isoenzymes; Male; Mixed Function Oxygenases; Phenobarbital; Phenol; Phenols; Rabbits | 1989 |
Studies on the mechanism of benzene toxicity.
Topics: Aldehydes; Animals; Benzene; Benzoquinones; Bone Marrow; Catechols; DNA; Drug Interactions; Female; Hydroquinones; Iron Radioisotopes; Mice; Phenol; Phenols; Quinones; Rats; Toluene | 1989 |
Role of oxygen radicals in induction of DNA damage by metabolites of benzene.
Topics: Benzene; DNA; DNA Damage; Free Radicals; Hydroquinones; Oxygen; Superoxide Dismutase; Superoxides | 1988 |
Inhibitory effect of benzene metabolites on nuclear DNA synthesis in bone marrow cells.
Topics: Animals; Benzene; Benzoquinones; Bone Marrow; Catechols; Cell Nucleus; Cell-Free System; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Hydroquinones; Mice; Mitochondria; Nucleic Acid Synthesis Inhibitors; Quinones | 1989 |
[Mutagenicity of benzene metabolites by fluctuation test].
Topics: Animals; Benzene; Benzoquinones; Biotransformation; Catechols; Hydroquinones; Male; Mutagenicity Tests; Phenol; Phenols; Quinones; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1988 |
Suppression of bone marrow stromal cell function by benzene and hydroquinone is ameliorated by indomethacin.
Topics: Animals; Benzene; Bone Marrow; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Hydroquinones; Indomethacin; Male; Mice; Mice, Inbred Strains; Prostaglandin-Endoperoxide Synthases; Prostaglandins E | 1987 |
Microenvironmental cytokines and expression of erythroid heme metabolic enzymes.
Topics: Ammonia-Lyases; Benzene; Biological Products; Bone Marrow Cells; Cytokines; Erythroblasts; Erythropoiesis; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Hydroquinones; Hydroxymethylbilane Synthase; Iron; Leukemia, Myeloid; Macrophages; Mixed Function Oxygenases; Neoplasm Proteins; Phenols; Recombinant Proteins; T-Lymphocytes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1987 |
Determination of catechol and quinol in the urine of workers exposed to benzene.
Topics: Benzene; Catechols; Chromatography, High Pressure Liquid; Environmental Exposure; Female; Humans; Hydroquinones; Male | 1988 |
Hydroquinone inhibits bone marrow pre-B cell maturation in vitro.
Topics: Animals; B-Lymphocytes; Benzene; Bone Marrow; Cells, Cultured; Female; Hematopoietic Stem Cells; Hydroquinones; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phenotype | 1987 |
Formation of reactive metabolites from benzene.
Topics: Animals; Benzene; Benzoquinones; Biotransformation; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; Guanine; Hydroquinones; Mass Spectrometry; Mitochondria; Quinones; Rabbits; Rats; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1987 |
DNA damage in L5178YS cells following exposure to benzene metabolites.
Topics: Animals; Benzene; Benzoquinones; Catechols; DNA, Neoplasm; Dose-Response Relationship, Drug; Hydroquinones; Leukemia L5178; Leukemia, Experimental; NADP; Phenol; Phenols; Quinones | 1986 |
Correlation between the induction of micronuclei in bone marrow by benzene exposure and the excretion of metabolites in urine of CD-1 mice.
Topics: Animals; Benzene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Bone Marrow; Catechols; Cell Nucleus; Chromosome Aberrations; Female; Hydroquinones; Male; Methylcholanthrene; Mice; Mutagenicity Tests; Phenol; Phenols; Proadifen; Toluene | 1986 |
Benzene myeloclastogenicity: a function of its metabolism.
Topics: Animals; Benzene; Benzoflavones; beta-Naphthoflavone; Bone Marrow; Catechols; Chromosome Aberrations; Enzyme Induction; Female; Germ-Free Life; Hydroquinones; Male; Methylcholanthrene; Mice; Mixed Function Oxygenases; Phenobarbital; Phenol; Phenols; Sex Factors | 1985 |
Covalent binding of benzene and its metabolites to DNA in rabbit bone marrow mitochondria in vitro.
Topics: Animals; Benzene; Benzoquinones; Bone Marrow; Catechols; DNA, Mitochondrial; Guanine Nucleotides; Hydroquinones; Hydroxides; Hydroxyl Radical; Male; Mitochondria; Nucleotides; Phenol; Phenols; Quinones; Rabbits; Rats; Rats, Inbred Strains; RNA | 1984 |
In vitro effects of benzene metabolites on mouse bone marrow stromal cells.
Topics: Animals; Benzene; Benzoquinones; Bone Marrow; Catechols; Dose-Response Relationship, Drug; Hematopoiesis; Hematopoietic Stem Cells; Hydroquinones; Male; Mice; Phenol; Phenols; Quinones | 1984 |
The use of liquid chromatography with dual-electrode electrochemical detection in the investigation of glutathione oxidation during benzene metabolism.
Topics: Animals; Benzene; Chromatography, Liquid; Electrochemistry; Glutathione; Hydroquinones; In Vitro Techniques; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Proteins | 1984 |
Prooxidant and antioxidant properties of iron-hydroquinone and iron-1,2,4-benzenetriol complex. Implications for benzene toxicity.
Topics: Animals; Antioxidants; Benzene; Bleomycin; Bone Marrow; Brain; Catalysis; DNA; Female; Glutamates; Glutamic Acid; Hydroquinones; In Vitro Techniques; Iron; Iron Chelating Agents; Lipid Peroxidation; Oxidants; Rats; Rats, Wistar | 1994 |
Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes.
Topics: Benzene; Cells, Cultured; Chromosome Aberrations; Chromosomes, Human, Pair 9; Diploidy; DNA Probes; Humans; Hydroquinones; In Situ Hybridization, Fluorescence; Interphase; Lymphocytes; Male; Mutagens | 1994 |
In vivo genotoxic interactions among three phenolic benzene metabolites.
Topics: Animals; Benzene; Catechols; Drug Interactions; Hydroquinones; Male; Mice; Micronuclei, Chromosome-Defective; Phenol; Phenols | 1994 |
Effect of the benzene metabolite, hydroquinone, on interleukin-1 secretion by human monocytes in vitro.
Topics: Benzene; Cell Survival; Cells, Cultured; Humans; Hydroquinones; Interleukin-1; Monocytes; Protein Biosynthesis; Proteins; RNA | 1995 |
Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor.
Topics: Animals; Arachidonate 5-Lipoxygenase; Benzene; Cell Differentiation; Cell Division; Cell Line; Granulocyte Colony-Stimulating Factor; Granulocytes; Hematopoiesis; Hematopoietic Stem Cells; Humans; Hydroquinones; Interleukin-3; Leukemia, Promyelocytic, Acute; Leukotriene Antagonists; Leukotriene D4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Protein Kinase C; Receptors, Leukotriene; Signal Transduction; Sphingosine; Tumor Cells, Cultured | 1995 |
Synergistic increase in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice.
Topics: Animals; Benzene; Chromatin; Chromosome Aberrations; DNA Repair; Drug Synergism; Hydroquinones; Male; Mice; Micronuclei, Chromosome-Defective; Phenol; Phenols; Staining and Labeling | 1995 |
Differences in xenobiotic detoxifying activities between bone marrow stromal cells from mice and rats: implications for benzene-induced hematotoxicity.
Topics: Animals; Benzene; Benzoquinones; Bone Marrow; Cells, Cultured; Glutathione; Hematologic Diseases; Hydroquinones; Inactivation, Metabolic; Male; Mice; Mice, Inbred DBA; NAD(P)H Dehydrogenase (Quinone); Rats; Rats, Sprague-Dawley; Species Specificity; Stromal Cells | 1995 |
In vitro conjugation of benzene metabolites by human liver: potential influence of interindividual variability on benzene toxicity.
Topics: Adolescent; Adult; Animals; Benzene; Biotransformation; Body Fluid Compartments; Child, Preschool; Female; Glucuronates; Humans; Hydroquinones; Inactivation, Metabolic; Individuality; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Middle Aged; Mutagens; Phenol; Phenols; Rats; Rats, Sprague-Dawley | 1995 |
Critical issues in benzene toxicity and metabolism: the effect of interactions with other organic chemicals on risk assessment.
Topics: Animals; Benzene; Bone Marrow; Cell Division; Drug Interactions; Ethanol; Female; Humans; Hydroquinones; Male; Mice; Micronuclei, Chromosome-Defective; Microsomes, Liver; Phenol; Phenols; Risk Assessment; Time Factors; Toluene | 1994 |
ESR evidence for the generation of reactive oxygen species from the copper-mediated oxidation of the benzene metabolite, hydroquinone: role in DNA damage.
Topics: Animals; Azides; Benzene; Catalase; Cattle; Chelating Agents; Copper; DNA Damage; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Glutathione; Hydrogen Peroxide; Hydroquinones; Mannitol; Mutagens; Oxidation-Reduction; Oxygen Consumption; Phenanthrolines; Radiation-Protective Agents; Reactive Oxygen Species; Sodium Azide; Superoxide Dismutase | 1995 |
Age-related changes in benzene disposition in male C57BL/6N mice described by a physiologically based pharmacokinetic model.
Topics: Adipose Tissue; Administration, Oral; Aging; Animals; Benzene; Biotransformation; Body Weight; Hydroquinones; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Perfusion; Sorbic Acid; Tissue Distribution | 1994 |
Distinct actions of benzene and its metabolites on nitric oxide production by bone marrow leukocytes.
Topics: Animals; Benzene; Benzoquinones; Bone Marrow Cells; Cytokines; Female; Hydroquinones; In Vitro Techniques; Interferon-gamma; Leukocytes; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Nitric Oxide; Recombinant Proteins | 1995 |
Erythroid progenitor cells that survive benzene exposure exhibit greater resistance to the toxic benzene metabolites benzoquinone and hydroquinone.
Topics: Animals; Benzene; Benzoquinones; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Drug Resistance; Erythroid Precursor Cells; Granulocytes; Hydroquinones; Liver; Male; Mice; Mice, Inbred C57BL; Species Specificity; Sulfhydryl Compounds | 1994 |
Benzene and benzene metabolites as embryotoxic agents: effects on cultured rat embryos.
Topics: Animals; Aroclors; Benzene; Benzene Derivatives; Benzoquinones; Carcinogens; Catechols; Cell Survival; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Embryo, Mammalian; Embryonic and Fetal Development; Hydroquinones; Male; Microsomes, Liver; Phenol; Phenols; Rats; Rats, Sprague-Dawley | 1994 |
Benzene metabolism by reconstituted cytochromes P450 2B1 and 2E1 and its modulation by cytochrome b5, microsomal epoxide hydrolase, and glutathione transferases: evidence for an important role of microsomal epoxide hydrolase in the formation of hydroquino
Topics: Animals; Benzene; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochromes b5; Epoxide Hydrolases; Glutathione; Glutathione Transferase; Hydroquinones; In Vitro Techniques; Liver; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenol; Phenols; Rats; Rats, Sprague-Dawley | 1993 |
Simultaneous determination of hydroquinone, catechol and phenol in urine using high-performance liquid chromatography with fluorimetric detection.
Topics: Animals; Benzene; Catechols; Chromatography, High Pressure Liquid; Humans; Hydroquinones; Indicators and Reagents; Male; Occupational Exposure; Phenol; Phenols; Rabbits; Smoking; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1993 |
Pharmacokinetic interaction between benzene metabolites, phenol and hydroquinone, in B6C3F1 mice.
Topics: Animals; Benzene; Drug Interactions; Glucuronates; Hydroquinones; Male; Mice; Mice, Inbred Strains; Models, Biological; Phenol; Phenols; Sulfates | 1994 |
Investigation of benzene-DNA adducts and their detection in human bone marrow.
Topics: Benzene; Benzoquinones; Bone Marrow; Cell Line; DNA; DNA Damage; Environmental Monitoring; Humans; Hydroquinones; In Vitro Techniques | 1993 |
Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo.
Topics: Animals; Benzene; Bone Marrow; Catechols; DNA; DNA Damage; Humans; Hydroquinones; Leukemia, Promyelocytic, Acute; Male; Mice; Mice, Inbred Strains; Oxidation-Reduction; Phenol; Phenols; Tumor Cells, Cultured | 1993 |
Inhibition of the conversion of pre-interleukins-1 alpha and 1 beta to mature cytokines by p-benzoquinone, a metabolite of benzene.
Topics: Benzene; Benzoquinones; Blotting, Western; Calpain; Caspase 1; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Hydroquinones; Indomethacin; Interleukin-1; Macrophages; Protein Precursors; Recombinant Proteins; Tumor Cells, Cultured | 1995 |
Differences in rates of benzene metabolism correlate with observed genotoxicity.
Topics: Acetone; Administration, Inhalation; Animals; Benzene; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Ditiocarb; Dose-Response Relationship, Drug; Enzyme Induction; Female; Hydroquinones; Injections, Intravenous; Liver; Male; Mice; Mutagens; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Phenols; Sex Characteristics; Sister Chromatid Exchange | 1996 |
Comparison of rat hepatic and pulmonary microsomal metabolism of benzene and the lack of benzene-induced pneumotoxicity and hepatotoxicity.
Topics: Animals; Benzene; Bronchoalveolar Lavage Fluid; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Ditiocarb; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; gamma-Glutamyltransferase; Hydroquinones; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Lung; Male; Microsomes; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Pyridines; Rats; Rats, Sprague-Dawley | 1995 |
Benzene: a case study in parent chemical and metabolite interactions.
Topics: Administration, Oral; Animals; Benzene; Benzoquinones; Drug Interactions; Drug Synergism; Hydroquinones; Male; Mice; Microsomes, Liver; Oxidation-Reduction; Peroxidase; Phenol; Phenols | 1995 |
Induction of apoptosis by benzene metabolites in HL60 and CD34+ human bone marrow progenitor cells.
Topics: Adult; Antigens, CD; Antigens, CD34; Apoptosis; Benzene; Benzene Derivatives; Biomarkers; Bone Marrow Cells; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Female; Hematopoietic Stem Cells; HL-60 Cells; Humans; Hydroquinones; Male; Phenols; Structure-Activity Relationship | 1996 |
Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor.
Topics: Animals; Benzene; Cell Differentiation; Cell Line; Granulocyte Colony-Stimulating Factor; Granulocytes; Hematopoiesis; Hematopoietic Stem Cells; Humans; Hydroquinones; Indomethacin; Leukemia, Myeloid, Acute; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Mice; Peroxidase; Propionates; Quinolines; Receptors, Leukotriene; Signal Transduction | 1996 |
Cytochromes P450 in benzene metabolism and involvement of their metabolites and reactive oxygen species in toxicity.
Topics: Animals; Benzene; Benzoquinones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; DNA Adducts; DNA Damage; Humans; Hydroquinones; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Proteins; Rats; Rats, Wistar; Reactive Oxygen Species | 1996 |
Impact of benzene metabolites on differentiation of bone marrow progenitor cells.
Topics: Animals; Benzene; Cell Differentiation; Colony-Forming Units Assay; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cells; Humans; Hydroquinones; Interleukin-3; Male; Mice; Mice, Inbred C57BL; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins | 1996 |
Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone.
Topics: Animals; Arachidonate 5-Lipoxygenase; Benzene; Carcinogens; Cell Differentiation; Granulocytes; HL-60 Cells; Humans; Hydroquinones; Leukemia, Myeloid, Acute; Leukotriene Antagonists; Leukotriene D4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Protein Kinase C; Receptors, Leukotriene | 1996 |
Inhibition of human DNA topoisomerase II by hydroquinone and p-benzoquinone, reactive metabolites of benzene.
Topics: Animals; Benzene; Benzoquinones; Carcinogens; DNA Damage; DNA, Kinetoplast; Enzyme Inhibitors; Humans; Hydroquinones; In Vitro Techniques; Leukemia, Myeloid, Acute; Topoisomerase II Inhibitors | 1996 |
Hydroquinone stimulates granulocyte-macrophage progenitor cells in vitro and in vivo.
Topics: Animals; Benzene; Colony-Forming Units Assay; Granulocytes; Hematopoiesis; Hematopoietic Stem Cells; Hydroquinones; In Vitro Techniques; Macrophages; Male; Mice; Mice, Inbred C57BL; Phenol; Phenols | 1996 |
Detection of DNA damage in human lymphocytes by alkaline single cell gel electrophoresis after exposure to benzene or benzene metabolites.
Topics: Age Factors; Benzene; Benzene Derivatives; Benzoquinones; Cytarabine; DNA Damage; DNA Repair; Electrophoresis, Agar Gel; Gasoline; Humans; Hydroquinones; Interphase; Lymphocytes; Male; Matched-Pair Analysis; Middle Aged; Mutagens; Occupational Exposure; Smoking | 1997 |
Biological monitoring of vehicle mechanics and other workers exposed to low concentrations of benzene.
Topics: Adult; Air Pollutants, Occupational; Belgium; Benzene; Breath Tests; Carcinogens; Catechols; Cross-Sectional Studies; Environmental Monitoring; Humans; Hydroquinones; Likelihood Functions; Male; Middle Aged; Motor Vehicles; Phenol; Phenols; Solvents | 1997 |
Identification of quinol thioethers in bone marrow of hydroquinone/phenol-treated rats and mice and their potential role in benzene-mediated hematotoxicity.
Topics: Animals; Benzene; Bone Marrow; Erythrocytes; Glutathione; Hydroquinones; Male; Mice; Mice, Inbred DBA; Phenol; Phenols; Rats; Rats, Sprague-Dawley | 1997 |
Hydroquinone, a reactive metabolite of benzene, inhibits NF-kappa B in primary human CD4+ T lymphocytes.
Topics: Benzene; CD4-Positive T-Lymphocytes; Cells, Cultured; Gene Expression Regulation; Humans; Hydroquinones; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Mutagens; NF-kappa B; Receptors, Interleukin-2; Signal Transduction; Tumor Necrosis Factor-alpha | 1998 |
Influence of gender and acetone pretreatment on benzene metabolism in mice exposed by nose-only inhalation.
Topics: Acetone; Administration, Inhalation; Animals; Benzene; Bone Marrow; Carbon Radioisotopes; Cytochrome P-450 CYP2E1; Enzyme Induction; Female; Hydroquinones; Hydroxylation; Liver; Male; Mice; Nasal Cavity; Phenol; Sex Factors; Solvents | 1998 |
Enhancement of myeloid cell growth by benzene metabolites via the production of active oxygen species.
Topics: Benzene; Benzoquinones; Catalase; Cell Cycle; Cell Division; DNA; Dose-Response Relationship, Drug; Flow Cytometry; HL-60 Cells; Humans; Hydroquinones; Oxygen; Reactive Oxygen Species; Time Factors; Xanthine; Xanthine Oxidase | 1999 |
A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity.
Topics: Adult; Amino Acid Substitution; Antigens, CD34; Apoptosis; Benzene; Bone Marrow Cells; Catechols; Enzyme Activation; Genetic Predisposition to Disease; Genotype; Homozygote; Humans; Hydroquinones; NAD(P)H Dehydrogenase (Quinone); Poisoning; Polymorphism, Genetic; Tumor Cells, Cultured | 1999 |
Modifications in the metabolic pathways of benzene in streptozotocin-induced diabetic rat.
Topics: Animals; Benzene; Catechols; Diabetes Mellitus, Experimental; Environmental Pollutants; Glucuronates; Hydroquinones; Inactivation, Metabolic; Male; Phenol; Rats; Rats, Sprague-Dawley; Sulfates | 1999 |
The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells.
Topics: Benzene; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 8; Hematopoietic Stem Cells; Humans; Hydroquinones; Leukemia, Myeloid, Acute; Mutagens; Myelodysplastic Syndromes; Sequence Deletion | 2000 |
Validation of biomarkers in humans exposed to benzene: urine metabolites.
Topics: Acetylcysteine; Adhesives; Adult; Benzene; Biomarkers; Catechols; China; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hydroquinones; Male; Mass Spectrometry; Mutagens; Occupational Exposure; Phenol; Reproducibility of Results; Sensitivity and Specificity; Shoes; Sorbic Acid | 2000 |
Utility of a mouse model for studying the effects of benzene on the myeloid lineage: effects of hydroquinone on a model myeloid system.
Topics: Animals; Apoptosis; Benzene; Cell Differentiation; Cells, Cultured; Granulocyte Colony-Stimulating Factor; Granulocytes; Hydroquinones; Interleukin-3; Leukotriene D4; Mice; Mice, Inbred C3H; Models, Animal; Mutagens; Myeloid Cells | 2000 |
Influence of culture conditions on the DNA-damaging effect of benzene and its metabolites in human peripheral blood mononuclear cells.
Topics: Benzene; Benzene Derivatives; Benzoquinones; Catechols; Cell Survival; Cells, Cultured; Chromosome Breakage; Comet Assay; Culture Media; Culture Techniques; DNA Damage; Dose-Response Relationship, Drug; Humans; Hydroquinones; Leukocytes, Mononuclear; Mutagenicity Tests; Phenol; Proteins | 2001 |
Benzene-free synthesis of hydroquinone.
Topics: Benzene; Chlorides; Escherichia coli; Fermentation; Glucose; Hydroquinones; Hypochlorous Acid; Oxidation-Reduction; Quinic Acid | 2001 |
Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice.
Topics: Animals; Benzene; Biotransformation; Catechols; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydroquinones; Isoenzymes; Lung; Mice; Mice, Knockout; Microsomes; Microsomes, Liver; Phenol | 2001 |
Effect of the microsomal system on quinone redox cycling, oxygen activation, and lipid peroxidation.
Topics: Animals; Benzene; Benzoquinones; Cytochrome P-450 CYP2E1; Hydroquinones; Lipid Peroxidation; Microsomes; NADP; Oxidation-Reduction; Oxygen; Rats | 2001 |
The interaction of 1,4-benzoquinone, a bioreactive intermediate of benzene, with three proteins essential for differentiation/maturation of the mouse myeloid stem cell.
Topics: Animals; Antioxidants; Apoptosis; Benzene; Benzoquinones; Caspase 3; Caspases; Cell Differentiation; DNA Topoisomerases, Type II; Hydroquinones; Membrane Proteins; Mice; Myeloid Cells; Receptors, Leukotriene | 2001 |
Aryl hydrocarbon receptor mediates benzene-induced hematotoxicity.
Topics: Administration, Inhalation; Animals; Benzene; Blood Cell Count; Bone Marrow Cells; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytochrome P-450 CYP2E1; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hydroquinones; Liver; Male; Mice; Mice, Knockout; Phenol; Receptors, Aryl Hydrocarbon; RNA, Messenger | 2002 |
Homologous recombination initiated by benzene metabolites: a potential role of oxidative stress.
Topics: Animals; Apoptosis; Benzene; Benzoquinones; Catalase; Catechols; CHO Cells; Cricetinae; Hydroquinones; Oxidative Stress; Phenol; Reactive Oxygen Species; Recombination, Genetic | 2003 |
Environmental benzene exposure assessment for parent-child pairs in Rouen, France.
Topics: Adult; Benzene; Child Day Care Centers; Child, Preschool; Environmental Monitoring; Environmental Pollutants; Female; France; Humans; Hydroquinones; Male; Parent-Child Relations; Sorbic Acid | 2003 |
Use of stable isotopically labeled benzene to evaluate environmental exposures.
Topics: Adult; Benzene; Biomarkers; Carbon Isotopes; Catechols; Environmental Exposure; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroquinones; Male; Middle Aged; Phenol; Sorbic Acid | 2003 |
Comparison of mutagenic potentials and mutation spectra of benzene metabolites using supF shuttle vectors in human cells.
Topics: Aldehydes; Benzene; DNA; Genetic Vectors; Humans; Hydroquinones; In Vitro Techniques; Mutagens; Plasmids; Point Mutation | 2004 |
Dysregulation of apoptosis by benzene metabolites and their relationships with carcinogenesis.
Topics: Acetylcysteine; Animals; Apoptosis; Benzene; Benzoquinones; Caspase 3; Caspases; Cell Division; Enzyme Activation; Guanosine; Hydroquinones; Mice; Neoplasms; NIH 3T3 Cells; Reactive Oxygen Species | 2004 |
Comparison of the mutagenic activity of the benzene metabolites, hydroquinone and para-benzoquinone in the supF forward mutation assay: a role for minor DNA adducts formed from hydroquinone in benzene mutagenicity.
Topics: Base Sequence; Benzene; Benzoquinones; DNA Adducts; DNA Primers; Genes, Suppressor; Humans; Hydroquinones; Molecular Sequence Data; Mutagenicity Tests; RNA, Transfer | 2004 |
Nonrandom aneuploidy of chromosomes 1, 5, 6, 7, 8, 9, 11, 12, and 21 induced by the benzene metabolites hydroquinone and benzenetriol.
Topics: Acute Disease; Benzene; Cells, Cultured; Chromosome Deletion; Chromosomes, Human; Female; Humans; Hydroquinones; In Situ Hybridization, Fluorescence; Leukemia, Myeloid; Lymphocytes; Monosomy; Mutagens; Poisson Distribution; Trisomy | 2005 |
Effects of co-exposure to extremely low frequency (ELF) magnetic fields and benzene or benzene metabolites determined in vitro by the alkaline comet assay.
Topics: Benzene; Catechols; Cell Survival; Comet Assay; DNA Damage; Electromagnetic Fields; Humans; Hydroquinones; Jurkat Cells; Mutagens | 2005 |
Inhibition of interleukin-12 production in mouse macrophages by hydroquinone, a reactive metabolite of benzene, via suppression of nuclear factor-kappaB binding activity.
Topics: Animals; Benzene; Cell Line; Female; Hydroquinones; I-kappa B Kinase; Interleukin-12; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Transcription, Genetic | 2005 |
Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene.
Topics: Benzene; Benzoquinones; Carcinogens; Dithiothreitol; DNA Topoisomerases, Type II; DNA, Kinetoplast; HL-60 Cells; Humans; Hydrogen Peroxide; Hydroquinones; Leukemia; Peroxidase; Topoisomerase II Inhibitors | 2005 |
Benzene metabolites block gap junction intercellular communication. Role in hematotoxicity and leukemia?
Topics: Aldehydes; Animals; Benzene; Cell Communication; Cell Line; Gap Junctions; Hematologic Diseases; Hydroquinones; Leukemia | 2005 |
Genotoxicity of the benzene metabolites para-benzoquinone and hydroquinone.
Topics: Benzene; Benzoquinones; Cell Line; Chromatography, High Pressure Liquid; DNA Adducts; Genes, Suppressor; Humans; Hydroquinones; Mutagenicity Tests; Phosphorus Radioisotopes; RNA, Transfer | 2005 |
Specific immune responses in workers exposed to benzene.
Topics: Adult; Air Pollutants, Occupational; Antibody Formation; Benzene; Benzoquinones; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroquinones; Immunoglobulin G; Male; Middle Aged; Occupational Exposure; Sorbic Acid | 2005 |
Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism.
Topics: Acetylcysteine; Adolescent; Adult; Benzene; Case-Control Studies; Catechols; Dose-Response Relationship, Drug; Female; Humans; Hydroquinones; Male; Middle Aged; Occupational Exposure; Phenol; Sorbic Acid; Urinalysis | 2006 |
Investigating the role of the aryl hydrocarbon receptor in benzene-initiated toxicity in vitro.
Topics: Animals; Benzene; Benzoquinones; Carcinogens; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Gene Expression; Hydroquinones; Mice; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Response Elements | 2007 |
The safety of hydroquinone.
Topics: Antioxidants; Benzene; Humans; Hydroquinones; Neoplasms | 2006 |
Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes.
Topics: Algorithms; Animals; Antimetabolites, Antineoplastic; Benzene; Benzoquinones; Catechols; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Doxorubicin; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Hydroquinones; Hydroxyl Radical; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Orchiectomy; Oxidative Stress; Structure-Activity Relationship; Swine; Swine, Miniature | 2007 |
Hydroquinone, a reactive metabolite of benzene, reduces macrophage-mediated immune responses.
Topics: Androstadienes; Animals; Benzene; Cell Adhesion; Cell Line; Chromones; Cytokines; Enzyme Activation; Heme Oxygenase-1; Hydroquinones; Immunity; Integrin beta1; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Morpholines; Nitric Oxide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Protoporphyrins; Reactive Oxygen Species; Signal Transduction; Wortmannin | 2007 |
The benzene metabolite hydroquinone enhances G2-chromosomal radiosensitivity by inducing a less-efficient G2-M-checkpoint in irradiated lymphocytes.
Topics: Benzene; Carcinogens; Cell Division; Cells, Cultured; Chromosome Aberrations; G2 Phase; Humans; Hydroquinones; Karyotyping; Lymphocytes; Marine Toxins; Oxazoles; Radiation Tolerance | 2007 |
Identification of human cell responses to benzene and benzene metabolites.
Topics: Anti-Inflammatory Agents; Benzene; Benzoquinones; Catechols; Cells, Cultured; Cytokines; Gene Expression Profiling; Humans; Hydroquinones; Interleukin-10; Leukocytes, Mononuclear; MAP Kinase Signaling System; Models, Biological; RNA | 2007 |
Benzene's metabolites alter c-MYB activity via reactive oxygen species in HD3 cells.
Topics: Acetyltransferases; Animals; Benzene; Benzene Derivatives; Benzoquinones; Carcinogens; Cell Line; Chickens; Dose-Response Relationship, Drug; Erythroblasts; Fluoresceins; Fluorescence; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Hydroquinones; Immunoblotting; Luciferases; Phenol; Polyethylene Glycols; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myb; Reactive Oxygen Species; Rhodamines; Superoxide Dismutase; Transfection | 2007 |
Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone.
Topics: Apoptosis; Benzene; Blotting, Western; Cell Proliferation; Comet Assay; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Exodeoxyribonucleases; Flow Cytometry; HeLa Cells; Histones; Humans; Hydroquinones; RecQ Helicases; RNA Interference; RNA, Small Interfering; Transfection; Tumor Suppressor Protein p53; Werner Syndrome Helicase | 2008 |
Benzene's toxicity: a consolidated short review of human and animal studies by HA Khan.
Topics: Animals; Benzene; Biotransformation; Bone Marrow; Cell Transformation, Neoplastic; Chromosome Aberrations; DNA; DNA Damage; Environmental Pollutants; Glutathione; Hematologic Neoplasms; Humans; Hydroquinones; Mutagens; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Phenol; Risk Assessment; Toxicity Tests | 2007 |
Synthesis of benzannulated N-heterocycles by a palladium-catalyzed C-C/C-N coupling of bromoalkylamines.
Topics: Alkylation; Amines; Benzene; Bromine Compounds; Carbon; Catalysis; Heterocyclic Compounds; Hydroquinones; Indoles; Molecular Structure; Nitrogen; Palladium | 2007 |
Studies in detoxication; the metabolism of benzene; the determination of phenol in urine with 2:6-dichloroquinonechloroimide; the excretion of phenol, glucuronic acid and ethereal sulphate by rabbits receiving benzene and phenol; observations on the deter
Topics: Animals; Benzene; Catechols; Glucuronic Acid; Humans; Hydroquinones; Phenol; Phenols; Rabbits; Sorbic Acid; Sulfates; Urine | 1949 |
Studies in detoxication; the metabolism of benzene; the isolation of phenol, catechol, quinol and hydroxyquinol from ethereal sulphate fraction of the urine of rabbits receiving benzene orally.
Topics: Animals; Benzene; Catechols; Hydroquinones; Phenol; Phenols; Rabbits; Sulfates; Urine | 1949 |
Studies in detoxication; the fates of quinol and resorcinol in the rabbit in relation to the metabolism of benzene.
Topics: Animals; Benzene; Hydroquinones; Rabbits; Resorcinols | 1949 |
Correlation of the aquarium goldfish toxicities of some phenols, quinones, and other benzene derivatives with their inhibition of autooxidative reactions.
Topics: Animals; Benzene; Benzene Derivatives; Fishes; Goldfish; Hydroquinones; Phenols; Quinones | 1949 |
Generation of phosphorylated histone H2AX by benzene metabolites.
Topics: Benzene; Benzoquinones; Cell Survival; DNA Breaks, Double-Stranded; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Histones; HL-60 Cells; Humans; Hydroquinones; Leukemia, Promyelocytic, Acute; Mutagens; Phosphorylation; Reactive Oxygen Species; Time Factors | 2008 |
Suppressive effect of hydroquinone, a benzene metabolite, on in vitro inflammatory responses mediated by macrophages, monocytes, and lymphocytes.
Topics: Animals; Benzene; Cell Adhesion; Cell Line; Cell Proliferation; Cells, Cultured; Flow Cytometry; Humans; Hydroquinones; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Lymphocytes; Macrophages; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Monocytes; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; U937 Cells | 2008 |
Investigation of solvent effects on UV-vis absorption spectra of dihydroxybenzene derivatives by solvatochromic parameters.
Topics: Benzene; Hydrogen; Hydroquinones; Molecular Structure; Resorcinols; Solvents; Spectrophotometry | 2009 |
The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells.
Topics: Benzene; Cell Line, Tumor; Chromosomes; DNA Damage; Dose-Response Relationship, Drug; Etoposide; Genomics; Humans; Hydroquinones; Lymphocytes; Metaphase; Mutagenicity Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Topoisomerase II Inhibitors | 2009 |
Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells.
Topics: Benzene; Bone Marrow Cells; Cell Line; Collagen; Drug Combinations; Endothelial Cells; Humans; Hydroquinones; Intercellular Signaling Peptides and Proteins; Laminin; Membrane Proteins; NAD(P)H Dehydrogenase (Quinone); Proteoglycans; RNA, Messenger; RNA, Small Interfering; Up-Regulation | 2009 |
Modulation of the benzene metabolite hydroquinone induced toxicity: evidence for an important role of fau.
Topics: Animals; Apoptosis; Benzene; Cell Line, Tumor; Cell Survival; Gene Expression; Hydroquinones; Mice; Ribosomal Proteins | 2010 |
Analysis of hydroquinone and catechol in peripheral blood of benzene-exposed workers.
Topics: Adult; Benzene; Catechols; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroquinones; Male; Middle Aged; Occupational Exposure; Sensitivity and Specificity | 2010 |
Human benzene metabolism following occupational and environmental exposures.
Topics: Benzene; Catechols; China; Environmental Exposure; Enzymes; Female; Humans; Hydroquinones; Models, Biological; Occupational Exposure; Phenol | 2010 |
Topoisomerase II inhibition by the bioactivated benzene metabolite hydroquinone involves multiple mechanisms.
Topics: Benzene; DNA; DNA Topoisomerases, Type II; Hydroquinones; Protein Binding; Topoisomerase II Inhibitors | 2010 |
Role of hydroquinone-thiol conjugates in benzene-mediated toxicity.
Topics: Animals; Benzene; Bone Marrow; Cell Line; Erythropoietin; Female; gamma-Glutamyltransferase; Hydroquinones; Lymphocyte Count; Male; Phenol; Rats; Sulfhydryl Compounds | 2010 |
The fate of benzene-oxide.
Topics: Aldehydes; Animals; Benzene; Bone Marrow; Cyclohexanes; Glutathione; Hydroquinones; Mice; Phenol; Rats | 2010 |
Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects.
Topics: Animals; Benzene; Chromatography, Liquid; Cysteine; Hydroquinones; Immunosuppressive Agents; Inhibitory Concentration 50; Male; Mass Spectrometry; Mercaptoethanol; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microscopy, Confocal; Proto-Oncogene Proteins c-akt | 2010 |
In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species.
Topics: Animals; Benzene; Cell Differentiation; Environmental Pollutants; Erythroid Cells; Erythroid Precursor Cells; Erythropoiesis; Female; Growth Inhibitors; Hydroquinones; Liver; Maternal Exposure; Metabolic Networks and Pathways; Mice; Models, Animal; Phenol; Pregnancy; Reactive Oxygen Species; Superoxide Dismutase | 2010 |
Defining the contribution of non-benzene sources of benzene metabolites in urine: implications for biomonitoring and risk assessment.
Topics: Acetylcysteine; Benzene; Benzene Derivatives; Catechols; Environmental Exposure; Humans; Hydroquinones; Phenol; Risk Assessment; Sorbic Acid | 2010 |
Hydroquinone, a benzene metabolite, induces Hog1-dependent stress response signaling and causes aneuploidy in Saccharomyces cerevisiae.
Topics: Aneuploidy; Benzene; Cell Cycle; Cell Cycle Proteins; Checkpoint Kinase 2; Genes, Fungal; Hydroquinones; Mitogen-Activated Protein Kinases; Mutagens; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Stress, Physiological | 2010 |
Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells.
Topics: Antigens, CD; Benzene; Cell Differentiation; Erythroid Precursor Cells; GATA1 Transcription Factor; GATA2 Transcription Factor; Glycophorins; Hemin; Hemoglobins; Humans; Hydroquinones; K562 Cells; Phenol; Receptors, Transferrin | 2011 |
Substrate interactions during the biodegradation of BTEX and THF mixtures by Pseudomonas oleovorans DT4.
Topics: Benzene; Benzene Derivatives; Biodegradation, Environmental; Catechols; Complex Mixtures; Furans; Gas Chromatography-Mass Spectrometry; Hydroquinones; Pseudomonas oleovorans; Time Factors; Toluene; Xylenes | 2011 |
Study on the cytogenetic changes induced by benzene and hydroquinone in human lymphocytes.
Topics: Adult; Animals; Apoptosis; Benzene; Cell Culture Techniques; Cell Cycle; Cell Survival; Cells, Cultured; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Environmental Pollutants; Flow Cytometry; Humans; Hydroquinones; Lymphocytes; Male; Principal Component Analysis; Rats; Rats, Wistar; Reactive Oxygen Species; Young Adult | 2012 |
Hydroquinone-induced apoptosis of human lymphocytes through caspase 9/3 pathway.
Topics: Apoptosis; Benzene; Caspase 3; Caspase 9; Cells, Cultured; Culture Media, Conditioned; Cytokines; Cytotoxins; Enzyme Activation; Humans; Hydroquinones; Lymphocytes; Phenol; Reactive Oxygen Species | 2012 |
How benzene and its metabolites affect human marrow derived mesenchymal stem cells.
Topics: Apoptosis; Benzene; Benzoquinones; Calcium-Binding Proteins; Caspases; Cell Survival; Chemokine CXCL12; Core Binding Factor Alpha 1 Subunit; Gene Expression Regulation; Humans; Hydroquinones; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Leukemia, Myeloid, Acute; Membrane Proteins; Mesenchymal Stem Cells; Real-Time Polymerase Chain Reaction; RNA; Serrate-Jagged Proteins; Stem Cell Factor; Young Adult | 2012 |
Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow.
Topics: Adult Stem Cells; Animals; Apoptosis; Benzene; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Colony-Forming Units Assay; Embryo, Mammalian; Hematopoietic Stem Cells; Hydroquinones; Male; Mice; Yolk Sac | 2013 |
Human CYP2E1-dependent and human sulfotransferase 1A1-modulated induction of micronuclei by benzene and its hydroxylated metabolites in Chinese hamster V79-derived cells.
Topics: Animals; Arylsulfotransferase; Benzene; Benzene Derivatives; Catechols; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP2E1; Humans; Hydroquinones; Hydroxyl Radical; Hydroxylation; Inactivation, Metabolic; Micronuclei, Chromosome-Defective; Micronucleus Tests | 2014 |
Aqueous benzene-diols react with an organic triplet excited state and hydroxyl radical to form secondary organic aerosol.
Topics: Aerosols; Benzene; Catechols; Hydroquinones; Hydroxyl Radical; Organic Chemicals; Resorcinols; Water | 2015 |
The molecular mechanisms of liver and islets of Langerhans toxicity by benzene and its metabolite hydroquinone in vivo and in vitro.
Topics: Animals; Apoptosis; Benzene; Biomarkers; DNA Damage; Dose-Response Relationship, Drug; Environmental Pollutants; Hydroquinones; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Lipid Peroxidation; Liver; Male; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Random Allocation; Rats, Wistar; Tissue Culture Techniques | 2015 |
Down-regulation of miRNA-451a and miRNA-486-5p involved in benzene-induced inhibition on erythroid cell differentiation in vitro and in vivo.
Topics: Adult; Animals; Benzene; CD4 Antigens; Cell Differentiation; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Hydroquinones; K562 Cells; Male; Mice, Inbred C57BL; MicroRNAs; Middle Aged | 2018 |
Assessment of genotoxicity of four volatile pollutants from cigarette smoke based on the in vitro γH2AX assay using high content screening.
Topics: A549 Cells; Acetaldehyde; Acrolein; Benzene; Cell Proliferation; Cell Survival; DNA Breaks, Double-Stranded; Dose-Response Relationship, Drug; Formaldehyde; Histones; Humans; Hydroquinones; Mutagenicity Tests; Time Factors; Tobacco Smoke Pollution | 2017 |
Non-parametric estimation of low-concentration benzene metabolism.
Topics: Acetylcysteine; Adult; Air Pollution, Indoor; Bayes Theorem; Benzene; Catechols; Creatinine; Environmental Monitoring; Female; Humans; Hydroquinones; Linear Models; Male; Middle Aged; Occupational Exposure; Phenol; Statistics, Nonparametric; Toluene; Young Adult | 2017 |
Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of β-catenin signaling.
Topics: Adolescent; Adult; Apoptosis; Benzene; beta Catenin; Bone Marrow Cells; Cell Survival; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Humans; Hydroquinones; Leukocytes, Mononuclear; Middle Aged; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Young Adult | 2018 |
Evidence for non-linear metabolism at low benzene exposures? A reanalysis of data.
Topics: Acetylcysteine; Air Pollution, Indoor; Algorithms; Benzene; Catechols; Humans; Hydroquinones; Occupational Exposure; Phenol; Sorbic Acid; Toluene | 2017 |
Benzene induces haematotoxicity by promoting deacetylation and autophagy.
Topics: Acetylation; Adult; Animals; Antigens, CD34; Apoptosis; Autophagy; Benzene; Bone Marrow Cells; Chloroquine; Female; Hematologic Diseases; Humans; Hydroquinones; Leukocytes, Mononuclear; Male; Mice; Models, Animal; Young Adult | 2019 |
Chemo- and Regioselective Dihydroxylation of Benzene to Hydroquinone Enabled by Engineered Cytochrome P450 Monooxygenase.
Topics: Benzene; Cytochrome P-450 Enzyme System; Escherichia coli; Glucosyltransferases; Hydroquinones; Hydroxylation; Models, Molecular; Oxidation-Reduction; Protein Engineering; Rauwolfia; Recombinant Proteins | 2019 |
Benzene metabolite hydroquinone promotes DNA homologous recombination repair via the NF-κB pathway.
Topics: Benzene; Carcinogenesis; Cell Line; DNA Breaks, Double-Stranded; DNA Repair; Hematopoietic Stem Cells; Homologous Recombination; Humans; Hydroquinones; Mutation; NF-kappa B; Phenylenediamines; RNA-Seq; Small Molecule Libraries | 2019 |
Up-regulation of DNMT3b contributes to HOTAIRM1 silencing via DNA hypermethylation in cells transformed by long-term exposure to hydroquinone and workers exposed to benzene.
Topics: Benzene; Case-Control Studies; Cell Line, Transformed; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroquinones; Leukemia, Myeloid, Acute; MicroRNAs; Occupational Diseases; Occupational Exposure; Promoter Regions, Genetic; Risk Assessment | 2020 |
The DNMT1-associated lncRNA UCA1 was upregulated in TK6 cells transformed by long-term exposure to hydroquinone and benzene-exposed workers via DNA hypomethylation.
Topics: Azacitidine; Benzene; Cell Line; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Humans; Hydroquinones; Hydroxamic Acids; Occupational Exposure; Promoter Regions, Genetic; RNA, Long Noncoding; Up-Regulation | 2021 |
PARP-1 modulates the expression of miR-223 through histone acetylation to involve in the hydroquinone-induced carcinogenesis of TK6 cells.
Topics: Acetylation; Benzene; Cell Transformation, Neoplastic; Epigenesis, Genetic; Histones; Humans; Hydroquinones; MicroRNAs; NF-kappa B; Poly(ADP-ribose) Polymerase Inhibitors | 2022 |
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Topics: Animals; Benzene; Endoplasmic Reticulum Stress; Humans; Hydroquinones; Inflammasomes; Lymphocytes; Oxidative Stress; Prospective Studies; Pyroptosis; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon | 2023 |
Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR.
Topics: Activating Transcription Factor 6; Apoptosis; Autophagy; Benzene; Endoplasmic Reticulum Stress; Humans; Hydroquinones; Reactive Oxygen Species; TOR Serine-Threonine Kinases | 2023 |
Benzene metabolite hydroquinone enhances self-renewal and proliferation of preleukemic cells through the Ppar-γ pathway.
Topics: Animals; Benzene; Cell Proliferation; Hydroquinones; Leukemia; Mice; PPAR gamma | 2023 |
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells.
Topics: Benzene; Decitabine; DNA; DNA Methylation; Humans; Hydroquinones; Poly(ADP-ribose) Polymerase Inhibitors; Promoter Regions, Genetic; RNA, Long Noncoding | 2023 |
The role of GATA switch in benzene metabolite hydroquinone inhibiting erythroid differentiation in K562 cells.
Topics: Benzene; Cell Differentiation; GATA1 Transcription Factor; Hemin; Humans; Hydroquinones; K562 Cells; RNA, Messenger | 2023 |