hydromorphone has been researched along with naltrexone in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (53.19) | 18.7374 |
| 1990's | 6 (12.77) | 18.2507 |
| 2000's | 8 (17.02) | 29.6817 |
| 2010's | 8 (17.02) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bousquet, AR; Howes, JF; Kotick, MP; Leland, DL; Polazzi, JO | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Denhardt, C; Ganorkar, R; Guo, C; Jin, J; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B | 1 |
| Resnick, RB; Volavka, J | 1 |
| Greenstein, R; O'Brien, C | 1 |
| Fishman, J; Foldes, FF; Hahn, EF; Ronai, AZ | 1 |
| Caruso, TP; Larson, DL; Portoghese, PS; Takemori, AE | 2 |
| Grabowski, J; Greenstein, R; McLellan, AT; O'Brien, CP; Ternes, J | 1 |
| Grabowski, J; Jordan-Hayes, J; O'Brien, CP; Ternes, JW; Wellerstein, H | 1 |
| Angel, L; Appelmans, N; Gioannini, TL; Koolpe, GA; Nelson, WL; Simon, EJ | 1 |
| Archer, S; Corbett, AD; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Seyed-Mozaffari, A; Ward, S | 1 |
| Goodman, RR; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Einarsson, M; Koman, A; Terenius, L | 1 |
| Erking, W; Lücker, PW; Wetzelsberger, N | 1 |
| Galetta, S; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Bickel, WK; Bigelow, GE; Jasinski, DR; Johnson, RE; Liebson, IA; Stitzer, ML | 1 |
| Botros, S; Larson, DL; Lipkowski, AW; Portoghese, PS; Stark, PA; Takemori, AE | 1 |
| Cheng, SW; North, WG; O'Connor, EF | 1 |
| Abdelhamid, EM; Archer, S; Koolpe, GA; Michael, J; Michael, M; Nelson, WL; Simon, EJ | 1 |
| Hahn, EF; Pasternak, GW | 1 |
| Armstrong, MJ; Larson, AA | 1 |
| Carroll-Buatti, M; Hahn, EF; Pasternak, GW | 1 |
| Giles, T; Merz, H; Sander, G | 1 |
| France, CP; Jacobson, AE; Woods, JH | 2 |
| Angel, L; Gioannini, TL; Koolpe, GA; Nelson, WL; Simon, EJ | 1 |
| Bigelow, GE; Preston, KL | 1 |
| Archer, S; Bidlack, JM; Jiang, Q; Seyed-Mozaffari, A | 1 |
| Bigelow, GE; Garner, JE; Preston, KL; Sullivan, JT; Walsh, SL | 1 |
| Manfredi, B; Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
| Fang, X; Larson, DL; Portoghese, PS | 1 |
| Schuh, KJ; Stitzer, ML; Walsh, SL | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| Gupta, SK; Sathyan, G; Thipphawong, J; Xu, E | 1 |
| Greenwald, MK | 1 |
| Ariyawansa, J; Marricco, NC; Moore, KT; Morelli, G; Natarajan, J; Pagé, V; Richarz, U; St-Fleur, D | 1 |
| Bigelow, GE; Dong, Q; Gastfriend, DR; Preston, KL; Schmittner, J | 1 |
| Craig, LB; Lofwall, MR; Nuzzo, PA; Siegel, AJ; Stoops, WW; Walsh, SL | 1 |
| Franc, MA; Francke, S; Lu, CC; Richards, H; Van Den Bergh, A; Vandenbossche, J | 1 |
| Blackney, KA; Edwards, DA; Kamdar, NV; Liu, CA | 1 |
2 review(s) available for hydromorphone and naltrexone
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
8 trial(s) available for hydromorphone and naltrexone
| Article | Year |
|---|---|
Differential naltrexone antagonism of hydromorphone and pentazocine effects in human volunteers.
Topics: Adult; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Humans; Hydromorphone; Male; Naltrexone; Pentazocine; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Effects of naltrexone on response to intravenous cocaine, hydromorphone and their combination in humans.
Topics: Adult; Buprenorphine; Cocaine; Cross-Over Studies; Double-Blind Method; Drug Interactions; Humans; Hydromorphone; Liver; Male; Naltrexone; Narcotic Antagonists; Narcotics; Respiration; Substance-Related Disorders | 1996 |
Onset, magnitude and duration of opioid blockade produced by buprenorphine and naltrexone in humans.
Topics: Adult; Buprenorphine; Cross-Over Studies; Double-Blind Method; Humans; Hydromorphone; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Time Factors | 1999 |
Pharmacokinetic profile of a 24-hour controlled-release OROS formulation of hydromorphone in the presence and absence of food.
Topics: Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Female; Food-Drug Interactions; Half-Life; Humans; Hydromorphone; Male; Middle Aged; Naltrexone; Narcotic Antagonists | 2007 |
A randomized study of the effects of food on the pharmacokinetics of once-daily extended-release hydromorphone in healthy volunteers.
Topics: Adult; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Confidence Intervals; Cross-Over Studies; Delayed-Action Preparations; Diet, High-Fat; Fasting; Female; Food-Drug Interactions; Humans; Hydromorphone; Male; Naltrexone; Therapeutic Equivalency | 2011 |
Opioid challenge evaluation of blockade by extended-release naltrexone in opioid-abusing adults: dose-effects and time-course.
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Hydromorphone; Male; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Oxygen; Pupil; Respiratory Rate; Skin Temperature; Time Factors | 2012 |
Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydromorphone; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Tramadol | 2012 |
The effect of UGT2B7*2 polymorphism on the pharmacokinetics of OROS® hydromorphone in Taiwanese subjects.
Topics: Adult; Analgesics, Opioid; Area Under Curve; Asian People; Delayed-Action Preparations; Female; Genotype; Glucuronates; Glucuronosyltransferase; Humans; Hydromorphone; Male; Naltrexone; Polymorphism, Genetic; Taiwan; Young Adult | 2014 |
37 other study(ies) available for hydromorphone and naltrexone
| Article | Year |
|---|---|
Analgesic narcotic antagonists. 8. 7 alpha-Alkyl-4,5 alpha-epoxymorphinan-6-ones.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Codeine; Hydrocodone; In Vitro Techniques; Mice; Narcotic Antagonists; Rats; Reaction Time | 1981 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Syntheses of novel high affinity ligands for opioid receptors.
Topics: Analgesics, Opioid; Crystallography, X-Ray; Furans; Humans; Ligands; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid | 2009 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation | 2019 |
Letter: Treatment of accidental naltrexone-induced withdrawal.
Topics: Adult; Humans; Hydromorphone; Male; Methadone; Naloxone; Naltrexone; Substance Withdrawal Syndrome | 1976 |
Naltrexone in a behavioral treatment program.
Topics: Behavior; Conditioning, Psychological; Extinction, Psychological; Humans; Hydromorphone; Injections; Naloxone; Naltrexone; Remission, Spontaneous; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1976 |
Orientation of the oxygen atom at C-6 as a determinant of agonistic activity in the oxymorphone series.
Topics: Animals; Guinea Pigs; Hydromorphone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxygen; Oxymorphone; Structure-Activity Relationship | 1977 |
Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity.
Topics: Alkylating Agents; Animals; Chlorambucil; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hydromorphone; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Norepinephrine; Oxymorphone; Phenoxybenzamine; Receptors, Opioid | 1979 |
Unreinforced self-injections: effects on rituals and outcome in heroin addicts.
Topics: Extinction, Psychological; Follow-Up Studies; Heroin Dependence; Humans; Hydromorphone; Male; Naloxone; Naltrexone; Reinforcement, Psychology; Research Design; Self Administration | 1979 |
Conditioned drug responses to naturalistic stimuli.
Topics: Conditioning, Psychological; Heart Rate; Humans; Hydromorphone; Methadone; Naltrexone; Opioid-Related Disorders; Personality Tests; Self Administration; Skin Temperature | 1979 |
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone.
Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry; Circular Dichroism; Epoxy Compounds; Ethers, Cyclic; Hydromorphone; Lactones; Male; Naloxone; Naltrexone; Oxymorphone; Propionates; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1985 |
10-Ketonaltrexone and 10-ketooxymorphone.
Topics: Animals; Biological Assay; Brain; Chemical Phenomena; Chemistry; Guinea Pigs; Hydromorphone; Ileum; Male; Mice; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1985 |
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
Topics: Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1985 |
Agonist-antagonist properties of fluorescent opioid probes in the guinea-pig myenteric plexus-longitudinal muscle preparation.
Topics: Animals; Chemical Phenomena; Chemistry; Depression, Chemical; Fluorescent Dyes; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Male; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Stereoisomerism; Stimulation, Chemical | 1985 |
High-pressure liquid chromatographic method for the determination of hydromorphone in human plasma with electrochemical detection.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hydromorphone; Naltrexone | 1986 |
Oxymorphone-naltrexonazine, a mixed opiate agonist-antagonist.
Topics: Analgesia; Animals; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; Male; Mice; Mice, Inbred ICR; Naltrexone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1987 |
Buprenorphine: dose-related blockade of opioid challenge effects in opioid dependent humans.
Topics: Adult; Buprenorphine; Dose-Response Relationship, Drug; Humans; Hydromorphone; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pupil; Respiration | 1988 |
Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine.
Topics: Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guinea Pigs; Hydromorphone; Male; Mice; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Structure-Activity Relationship | 1989 |
Simultaneous extraction and chromatographic analysis of morphine, dilaudid, naltrexone and naloxone in biological fluids by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Hydromorphone; Male; Morphine; Naloxone; Naltrexone; Rats | 1989 |
Chloroacryloyl amides and alpha-methylenelactones from naltrexone, oxymorphone and fentanyl.
Topics: Acrylates; Animals; Binding Sites; Brain; Chemical Phenomena; Chemistry; Fentanyl; Hydromorphone; In Vitro Techniques; Membranes; Naloxone; Naltrexone; Oxymorphone; Rats; Stereoisomerism | 1985 |
Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones.
Topics: Analgesics, Opioid; Animals; Brain; Delayed-Action Preparations; Hydrazones; Hydromorphone; In Vitro Techniques; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Receptors, Opioid | 1980 |
Morphine analgesia after intrathecal administration of a narcotic agonist, chloroxymorphamine and antagonist, chlornaltrexamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydromorphone; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone; Rats | 1980 |
Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine.
Topics: Analgesics; Animals; Brain; Hydromorphone; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone | 1980 |
Irreversible opiate agonists and antagonists: the 14-hydroxydihydromorphinone azines.
Topics: Animals; Brain; Cell Membrane; Dihydromorphine; Drug Stability; Hydromorphone; Kinetics; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship | 1982 |
Quaternary opiate antagonists lower blood pressure and inhibit leucine-enkephalin responses.
Topics: Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Heart Rate; Hydromorphone; Naloxone; Naltrexone; Oxymorphone; Quaternary Ammonium Compounds | 1983 |
Discriminative stimulus effects of reversible and irreversible opiate agonists: morphine, oxymorphazone and buprenorphine.
Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Hydromorphone; Morphinans; Morphine; Naltrexone; Oxymorphone; Time Factors | 1984 |
Irreversible and reversible narcotic agonists: discriminative and analgesic effects of buprenorphine, oxymorphazone, and morphine.
Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Hydromorphone; Mice; Morphinans; Morphine; Naltrexone; Nociceptors; Oxymorphone | 1984 |
Diastereomeric 6-desoxy-6-spiro-alpha-methylene-gamma-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted michael acceptor liga
Topics: Animals; Brain; Cell Membrane; Chromatography, Thin Layer; Hydromorphone; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Conformation; Naloxone; Naltrexone; Narcotic Antagonists; Optical Rotation; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1984 |
Antinociceptive evaluation of 14 beta-(bromoacetamido)-7,8-dihydro- N(cyclopropylmethyl)-normorphinone in mice.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Cattle; Corpus Striatum; Drug Interactions; Hydromorphone; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study.
Topics: Animals; Cell Division; Codeine; Hydromorphone; Immune System; Immunosuppression Therapy; Interleukin-2; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Oxycodone; Structure-Activity Relationship | 1997 |
7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.
Topics: Animals; Electric Stimulation; Guinea Pigs; Hydromorphone; In Vitro Techniques; Ligands; Male; Mice; Molecular Conformation; Molecular Structure; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotics; Oxymorphone; Receptors, Opioid, delta; Spiro Compounds; Structure-Activity Relationship | 1997 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Behavioral economic analysis of drug preference using multiple choice procedure data.
Topics: Choice Behavior; Economics; Fentanyl; Fluoxetine; Hallucinogens; Humans; Hydromorphone; Injections, Intramuscular; Methadone; Models, Psychological; Motivation; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Narcotics; Psychotropic Drugs; Recreation; Selective Serotonin Reuptake Inhibitors; Substance Abuse, Intravenous; Substance-Related Disorders | 2008 |
Methylnaltrexone-Associated Bowel Perforation in Postoperative Opioid-Induced Constipation and Ogilvie Syndrome: A Case Report.
Topics: Analgesics, Opioid; Colonic Pseudo-Obstruction; Constipation; Decompression, Surgical; Humans; Hydromorphone; Intestinal Perforation; Low Back Pain; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Postoperative Complications; Quaternary Ammonium Compounds; Spinal Stenosis | 2019 |