hydromorphone has been researched along with naloxone in 98 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 60 (61.22) | 18.7374 |
1990's | 10 (10.20) | 18.2507 |
2000's | 15 (15.31) | 29.6817 |
2010's | 11 (11.22) | 24.3611 |
2020's | 2 (2.04) | 2.80 |
Authors | Studies |
---|---|
Howes, JF; Kotick, MP; Osgood, PF; Polazzi, JO; Razdan, RK; Schut, RN; Villarreal, JE | 1 |
Kotick, MP; Leland, DL | 1 |
Strassburg, CP; Tukey, RH | 1 |
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Pasternak, GW; Snyder, SH; Wilson, HA | 2 |
Pollock, SH | 1 |
Pasternak, GW; Snowman, AM; Snyder, SH | 1 |
Resnick, RB; Volavka, J | 1 |
Horng, JS; Smits, SE; Wong, DT | 1 |
Abbott, J; Blosser, J; Shain, W | 1 |
Simantov, R; Snowman, AM; Snyder, SH | 1 |
Simantov, R; Snyder, SH | 1 |
Greenstein, R; O'Brien, C | 1 |
Fishman, J; Foldes, FF; Hahn, EF; Ronai, AZ | 1 |
Geisow, MJ; Smyth, DG | 1 |
Caruso, TP; Larson, DL; Portoghese, PS; Takemori, AE | 2 |
Baskerville, JC; Brands, B; Gowdey, CW; Hirst, M | 1 |
Grabowski, J; Greenstein, R; McLellan, AT; O'Brien, CP; Ternes, J | 1 |
Bigelow, GE; Liebson, IA; Preston, KL; Strain, EC | 3 |
Fudala, PJ; Johnson, RE | 1 |
Kumagai, Y; Todaka, T; Toki, S | 1 |
Bigelow, GE; Liebson, IA; Preston, KL | 6 |
Bigelow, GE; Liebson, I; Preston, KL; Strain, EC | 1 |
Angel, L; Appelmans, N; Gioannini, TL; Koolpe, GA; Nelson, WL; Simon, EJ | 1 |
Archer, S; Corbett, AD; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Seyed-Mozaffari, A; Ward, S | 1 |
Goodman, RR; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
Hahn, EF; Itzhak, Y; Johnson, N; Nishimura, S; Pasternak, GW | 1 |
Randall, JI; Rodgers, RJ | 1 |
Einarsson, M; Koman, A; Terenius, L | 1 |
Ikebuchi, H; Nagamatsu, K; Ohno, Y; Takahashi, A; Takanaka, A; Terao, T | 1 |
Benyhe, S; Borsodi, A; Hosztafi, S; Toth, G; Varga, E | 1 |
Ehrman, RN; O'Brien, CP; Ternes, JW | 1 |
Larson, DL; Lemieux, C; Nguyen, TM; Portoghese, PS; Ronsisvalle, G; Schiller, PW; Takemori, AE | 1 |
Bickel, W; Bigelow, GE; Liebson, IA; Preston, KL | 1 |
Bodnar, RJ; Burks, TF; Clark, JE; Hahn, EF; Pasternak, GW; Williams, CL | 1 |
Foley, KM; Houde, RW; Inturrisi, CE; Moulin, DE; Nip, TJ; Reidenberg, B; Wallenstein, S; Weinberg, DS | 1 |
Benyhe, S; Borsodi, A; Hoffmann, G; Hosztafi, S; Toth, G; Varga, E; Wollemann, M | 1 |
Cheng, SW; North, WG; O'Connor, EF | 1 |
Copland, VS; Haskins, SC; Patz, J | 1 |
Ebertz, JM; Hanifin, JM; Hermens, JM; Hirshman, CA | 1 |
Abdelhamid, EM; Archer, S; Koolpe, GA; Michael, J; Michael, M; Nelson, WL; Simon, EJ | 1 |
Gorodetzky, CW | 1 |
Hug, CC; Vasko, MR | 1 |
Pasternak, G; Pert, CB; Snyder, SH | 1 |
Terenius, L | 1 |
Klee, WA; Streaty, RA | 1 |
Bigelow, GE; Liebson, IA; Preston, KL; Stitzer, ML | 1 |
Hahn, EF; Pasternak, GW | 1 |
Armstrong, MJ; Larson, AA | 1 |
Kanel, GC; Needham, WP; Shuster, L; Thompson, ML | 1 |
Carroll-Buatti, M; Hahn, EF; Pasternak, GW | 1 |
Ishida, T; Kido, Y; Nagamatsu, K; Terao, T; Toki, S | 1 |
Hemmer, RC; Kastin, AJ; McLean, JH; Olson, GA; Olson, RD | 1 |
Ehrman, R; O'Brien, CP; Ternes, JW | 1 |
Giles, T; Merz, H; Sander, G | 1 |
Cooper, SJ; Turkish, S | 1 |
Dashwood, MR; Kiang, JG; Wei, ET | 1 |
Jacob, JJ; Rios, L | 1 |
Galetta, S; Ling, GS; Pasternak, GW | 1 |
Angel, L; Gioannini, TL; Koolpe, GA; Nelson, WL; Simon, EJ | 1 |
Manfredi, B; Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
Borowitz, JL; Gunasekar, PG; Isom, GE | 1 |
Hameedi, FA; Kosten, TA; Kosten, TR; Oliveto, AH; Rosen, MI; Woods, SW | 1 |
Bigelow, GE; Stoller, K; Strain, EC; Walsh, SL | 1 |
Bigelow, GE; Stoller, KB; Strain, EC; Walsh, SL | 1 |
Bigelow, GE; Strain, EC; Walsh, SL | 1 |
Cohen, SP; Mao, J | 1 |
Compton, P; Elashoff, D; Miotto, K | 1 |
Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE | 1 |
Borowitz, JL; Gunasekar, PG; Isom, GE; Li, L; Prabhakaran, K; Zhang, L | 1 |
Bigelow, GE; Carroll, CP; Preston, KL; Strain, EC; Walsh, SL | 1 |
Hofmann, A; Lafontaine, AL; Postuma, RB; Tangri, N | 1 |
Bigelow, GE; Correia, CJ; Strain, EC; Walsh, SL | 1 |
Mushlin, N; Roberts, R; Vahid, B | 1 |
Bernstein, RA; Dubow, J | 1 |
Bigelow, GE; Correia, CJ; Duke, AN; Strain, EC; Walsh, SL | 1 |
Bigelow, GE; Lanier, RK; Lofwall, MR; Mintzer, MZ; Strain, EC | 1 |
Chang-Chien, GC; Chu, SK; Joseph, P; McCormick, Z | 1 |
Albertson, TE; Chenoweth, JA; Clarke, SO; Gutierrez, R; Roche, BM; Sutter, ME; Wintemute, GJ | 1 |
Kharasch, S; Kostic, M; Schultz, ML | 1 |
Bailey, AM; Baum, RA; Horn, K; Justice, SN; Lewis, T; Morizio, K; Schultz, A; Weant, K | 1 |
Anis, AH; Brissette, S; Guh, D; Harrison, S; Janmohamed, A; Jutha, S; Krausz, M; MacDonald, S; Marchand, K; Marsh, DC; Oviedo-Joekes, E; Schechter, MT; Zhang, DZ | 1 |
Arthur, K; Davis, C; Fuller, J; Geik, C; Johnston, E; Leung, E; Levitt, F; McCart, G; McMichael, D; Painter, J; Staublin, T; Walroth, T | 1 |
Holland, TL; Neuss, MJ | 1 |
Baetge, CL; Coursey, CD; Lizarraga, I; Scallan, EM; Simon, BT | 1 |
Churchill, B; Root-Bernstein, R; Turke, M | 1 |
Caputo, A; Christopher, C; Compton, P; Delgado, MK; Lowenstein, M; McFadden, R; Olenik, JM; Perrone, J; Ronning, K; Sigueza, AL; Thakrar, AP; Uritsky, TJ; Winston, A | 1 |
3 review(s) available for hydromorphone and naloxone
Article | Year |
---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Review of Intranasally Administered Medications for Use in the Emergency Department.
Topics: Administration, Intranasal; Anesthetics, Dissociative; Anticonvulsants; Antidotes; Antipsychotic Agents; Dexmedetomidine; Emergency Service, Hospital; Fentanyl; Flumazenil; Haloperidol; Humans; Hydromorphone; Hypnotics and Sedatives; Ketamine; Lorazepam; Midazolam; Naloxone; Narcotic Antagonists; Narcotics | 2017 |
16 trial(s) available for hydromorphone and naloxone
Article | Year |
---|---|
Acute effects of buprenorphine, hydromorphone and naloxone in methadone-maintained volunteers.
Topics: Adult; Buprenorphine; Cognition; Drug Interactions; Hemodynamics; Humans; Hydromorphone; Injections, Intramuscular; Male; Methadone; Naloxone; Psychomotor Performance; Substance Abuse Treatment Centers; Substance-Related Disorders | 1992 |
Development of buprenorphine for the treatment of opioid dependence.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Follow-Up Studies; Heroin Dependence; Humans; Hydromorphone; Male; Middle Aged; Naloxone; Substance Withdrawal Syndrome; Testosterone | 1992 |
Buprenorphine and naloxone alone and in combination in opioid-dependent humans.
Topics: Adult; Blood Pressure; Body Temperature; Buprenorphine; Cognition; Heart Rate; Humans; Hydromorphone; Male; Naloxone; Opioid-Related Disorders; Psychomotor Performance; Respiration; Substance Withdrawal Syndrome | 1988 |
Butorphanol-precipitated withdrawal in opioid-dependent human volunteers.
Topics: Adult; Butorphanol; Cognition; Double-Blind Method; Humans; Hydromorphone; Injections, Intramuscular; Male; Methadone; Morphinans; Naloxone; Opioid-Related Disorders; Psychomotor Performance; Substance Withdrawal Syndrome | 1988 |
Antagonist effects of nalbuphine in opioid-dependent human volunteers.
Topics: Adult; Dose-Response Relationship, Drug; Humans; Hydromorphone; Male; Methadone; Morphinans; Nalbuphine; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1989 |
Precipitated withdrawal by pentazocine in methadone-maintained volunteers.
Topics: Adult; Behavior; Humans; Hydromorphone; Male; Methadone; Naloxone; Pentazocine; Psychomotor Performance; Substance Withdrawal Syndrome; Time Factors | 1993 |
Opioid antagonist effects of dezocine in opioid-dependent humans.
Topics: Adult; Bridged Bicyclo Compounds, Heterocyclic; Cognition; Cycloparaffins; Humans; Hydromorphone; Male; Monitoring, Physiologic; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Psychomotor Performance; Surveys and Questionnaires; Tetrahydronaphthalenes | 1996 |
Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers.
Topics: Administration, Sublingual; Adult; Analgesics, Opioid; Buprenorphine; Drug Combinations; Humans; Hydromorphone; Injections, Intravenous; Male; Middle Aged; Motor Activity; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Tablets; Time Factors | 2000 |
Effects of buprenorphine/naloxone in opioid-dependent humans.
Topics: Administration, Sublingual; Adolescent; Adult; Affect; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydromorphone; Injections, Intramuscular; Male; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Observer Variation; Opioid-Related Disorders; Psychomotor Performance; Substance Withdrawal Syndrome | 2001 |
Blockade of hydromorphone effects by buprenorphine/naloxone and buprenorphine.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydromorphone; Male; Naloxone; Narcotic Antagonists; Opioid-Related Disorders | 2002 |
Precipitated opioid withdrawal across acute physical dependence induction methods.
Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Heart Rate; Humans; Hydromorphone; Injections, Intramuscular; Injections, Intravenous; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pupil; Respiratory Mechanics; Substance Withdrawal Syndrome; Substance-Related Disorders | 2004 |
Effects associated with double-blind omission of buprenorphine/naloxone over a 98-h period.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hydromorphone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2006 |
Acute effects of intramuscular and sublingual buprenorphine and buprenorphine/naloxone in non-dependent opioid abusers.
Topics: Administration, Sublingual; Adult; Buprenorphine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Users; Female; Humans; Hydromorphone; Injections, Intramuscular; Male; Middle Aged; Naloxone; Opioid-Related Disorders; Surveys and Questionnaires | 2010 |
Physical dependence potential of daily tramadol dosing in humans.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydromorphone; Male; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome; Tramadol | 2010 |
Safety profile of injectable hydromorphone and diacetylmorphine for long-term severe opioid use disorder.
Topics: Adult; Analgesics, Opioid; Canada; Double-Blind Method; Drug Overdose; Female; Heroin; Heroin Dependence; Humans; Hydromorphone; Injections; Male; Middle Aged; Naloxone; Opioid-Related Disorders; Self Administration; Severity of Illness Index; Time Factors | 2017 |
The antinociceptive effects of intravenous administration of three doses of butorphanol tartrate or naloxone hydrochloride following hydromorphone hydrochloride to healthy conscious cats.
Topics: Administration, Intravenous; Analgesics, Opioid; Animals; Butorphanol; Cats; Cross-Over Studies; Drug Therapy, Combination; Female; Hydromorphone; Naloxone; Pain; Pain Measurement; Random Allocation; Skin Temperature | 2019 |
79 other study(ies) available for hydromorphone and naloxone
Article | Year |
---|---|
Analgesic narcotic antagonists. 2. 8-Alkymorphinan-6-ones.
Topics: Acetates; Analgesics; Animals; Haplorhini; Humans; Mice; Morphinans; Morphine Dependence; Narcotic Antagonists; Rats; Reaction Time; Structure-Activity Relationship; Substance Withdrawal Syndrome; Substance-Related Disorders | 1980 |
Analgesic narcotic antagonists. 4. 7-Methyl-N-(cycloalkylmethyl)-3-hydroxymorphinan-6-ones and -isomorphinan-6-ones.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Humans; Morphinans; Morphine Dependence; Narcotic Antagonists; Substance Withdrawal Syndrome | 1980 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Differentiation of opiate agonist and antagonist receptor binding by protein modifying reagents.
Topics: Animals; Binding Sites; Brain; Chloromercuribenzoates; Ethylmaleimide; Hydromorphone; In Vitro Techniques; Iodoacetates; Levallorphan; Levorphanol; Naloxone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Receptors, Drug; Structure-Activity Relationship; Sulfhydryl Reagents; Tritium | 1975 |
Differential effects of protein-modifying reagents on receptor binding of opiate agonists and antagonists.
Topics: Animals; Binding Sites; Hydromorphone; In Vitro Techniques; Iodoacetamide; Male; Mercury; Naloxone; Narcotic Antagonists; Organometallic Compounds; Rats; Receptors, Drug; Sodium; Sulfhydryl Reagents; Temperature | 1975 |
Dihydromorphinine ketone reductases.
Topics: Alcohol Oxidoreductases; Animals; Chickens; Cytosol; Hydromorphone; Ketamine; Liver; Molecular Weight; Morphine; NADH, NADPH Oxidoreductases; Naloxone; Rabbits; Species Specificity; Structure-Activity Relationship | 1975 |
Selective enhancement of [3H]opiate agonist binding by divalent cations.
Topics: Animals; Brain; Cations, Divalent; Chelating Agents; Hydromorphone; Magnesium; Male; Manganese; Morphine Derivatives; Naloxone; Narcotic Antagonists; Rats; Receptors, Drug; Sodium | 1975 |
Letter: Treatment of accidental naltrexone-induced withdrawal.
Topics: Adult; Humans; Hydromorphone; Male; Methadone; Naloxone; Naltrexone; Substance Withdrawal Syndrome | 1976 |
The binding of the optical isomers of methadone, alpha-methadol, alpha-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain.
Topics: Animals; Brain; Dealkylation; Hydromorphone; In Vitro Techniques; Isomerism; Methadone; Methadyl Acetate; Naloxone; Rats; Receptors, Drug | 1976 |
Sympathetic ganglion cell C neuroblastoma hybrids with opiate receptors.
Topics: Animals; Binding, Competitive; Cell Line; Ganglia, Spinal; Hydromorphone; Mice; Morphine Derivatives; Naloxone; Neuroblastoma; Receptors, Opioid | 1976 |
Temperature and ionic influences on opiate receptor binding.
Topics: Animals; Antimetabolites; Brain; Calcium; Cations, Divalent; Cations, Monovalent; Cesium; Hydromorphone; In Vitro Techniques; Lithium; Magnesium; Male; Manganese; Naloxone; Rats; Receptors, Opioid; Sodium; Temperature | 1976 |
Morphine-like peptides, leucine enkephalin and methionine enkephalin: interactions with the opiate receptor.
Topics: Animals; Bacitracin; Binding, Competitive; Cations, Divalent; Cations, Monovalent; Hydromorphone; In Vitro Techniques; Kinetics; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Serum Albumin, Bovine; Temperature; Time Factors | 1976 |
Naltrexone in a behavioral treatment program.
Topics: Behavior; Conditioning, Psychological; Extinction, Psychological; Humans; Hydromorphone; Injections; Naloxone; Naltrexone; Remission, Spontaneous; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1976 |
Orientation of the oxygen atom at C-6 as a determinant of agonistic activity in the oxymorphone series.
Topics: Animals; Guinea Pigs; Hydromorphone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxygen; Oxymorphone; Structure-Activity Relationship | 1977 |
Preparation and properties of lipotropin C-fragment with anionic substituents attached to the lysine residues.
Topics: Animals; beta-Lipotropin; Binding, Competitive; Brain; Hydromorphone; Lysine; Naloxone; Peptide Fragments; Rats; Receptors, Opioid | 1977 |
Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity.
Topics: Alkylating Agents; Animals; Chlorambucil; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hydromorphone; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Norepinephrine; Oxymorphone; Phenoxybenzamine; Receptors, Opioid | 1979 |
Dependence in rats after one injection of heroin-, LAAM- or hydromorphone-zinc tannate.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Heroin; Heroin Dependence; Humans; Hydromorphone; Methadone; Methadyl Acetate; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1979 |
Unreinforced self-injections: effects on rituals and outcome in heroin addicts.
Topics: Extinction, Psychological; Follow-Up Studies; Heroin Dependence; Humans; Hydromorphone; Male; Naloxone; Naltrexone; Reinforcement, Psychology; Research Design; Self Administration | 1979 |
A new metabolic pathway of morphine: in vivo and in vitro formation of morphinone and morphine-glutathione adduct in guinea pig.
Topics: Animals; Bile; Glutathione; Guinea Pigs; Hydromorphone; In Vitro Techniques; Lithocholic Acid; Liver; Male; Morphine; Naloxone | 1990 |
Discrimination of butorphanol and nalbuphine in opioid-dependent humans.
Topics: Adult; Behavior; Blood Pressure; Body Temperature; Butorphanol; Discrimination, Psychological; Generalization, Psychological; Humans; Hydromorphone; Male; Methadone; Middle Aged; Nalbuphine; Naloxone; Psychomotor Performance; Pupil; Receptors, Opioid | 1990 |
The effects of buprenorphine in methadone-dependent volunteers.
Topics: Buprenorphine; Double-Blind Method; Humans; Hydromorphone; Male; Methadone; Naloxone; Opioid-Related Disorders; Pupil | 1990 |
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone.
Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry; Circular Dichroism; Epoxy Compounds; Ethers, Cyclic; Hydromorphone; Lactones; Male; Naloxone; Naltrexone; Oxymorphone; Propionates; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1985 |
10-Ketonaltrexone and 10-ketooxymorphone.
Topics: Animals; Biological Assay; Brain; Chemical Phenomena; Chemistry; Guinea Pigs; Hydromorphone; Ileum; Male; Mice; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1985 |
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
Topics: Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1985 |
Irreversible opiate agonists and antagonists. III. Phenylhydrazone derivatives of naloxone and oxymorphone.
Topics: Albumins; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrazones; Hydromorphone; In Vitro Techniques; Male; Naloxone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship; Tritium | 1985 |
Social conflict analgesia: studies on naloxone antagonism and morphine cross-tolerance in male DBA/2 mice.
Topics: Analgesia; Animals; Conflict, Psychological; Drug Tolerance; Hydromorphone; Male; Mice; Mice, Inbred DBA; Morphine; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Oxymorphone | 1985 |
Agonist-antagonist properties of fluorescent opioid probes in the guinea-pig myenteric plexus-longitudinal muscle preparation.
Topics: Animals; Chemical Phenomena; Chemistry; Depression, Chemical; Fluorescent Dyes; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Male; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Stereoisomerism; Stimulation, Chemical | 1985 |
Morphine metabolism in isolated rat hepatocytes and its implications for hepatotoxicity.
Topics: Animals; Cell Survival; Glutathione; Hydromorphone; Isoenzymes; L-Lactate Dehydrogenase; Liver; Male; Morphine; Morphine Derivatives; Naloxone; Perfusion; Rats; Rats, Inbred Strains | 1986 |
Synthesis and binding of 3H-oxymorphazone to rat brain membranes.
Topics: Animals; Binding, Competitive; Brain; Hydromorphone; In Vitro Techniques; Isotope Labeling; Kinetics; Naloxone; Oxymorphone; Radioligand Assay; Rats; Receptors, Opioid; Tritium | 1987 |
Nondependent monkeys self-administer hydromorphone.
Topics: Animals; Cocaine; Drug Tolerance; Hydromorphone; Macaca; Macaca fascicularis; Macaca mulatta; Naloxone; Opioid-Related Disorders; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders | 1985 |
Hybrid bivalent ligands with opiate and enkephalin pharmacophores.
Topics: Analgesics; Animals; Enkephalins; Guinea Pigs; Hydromorphone; Ligands; Male; Mice; Muscle, Smooth; Naloxone; Oxymorphone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Three-choice drug discrimination in opioid-dependent humans: hydromorphone, naloxone and saline.
Topics: Adult; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Humans; Hydromorphone; Male; Methadone; Naloxone; Opioid-Related Disorders; Psychomotor Performance | 1987 |
Abuse liability assessment of buprenorphine-naloxone combinations.
Topics: Blood Pressure; Buprenorphine; Drug Combinations; Heart Rate; Humans; Hydromorphone; Male; Naloxone; Pupil; Respiration; Skin Temperature; Substance-Related Disorders; Surveys and Questionnaires | 1987 |
Butorphanol-precipitated withdrawal in opioid-dependent human volunteers.
Topics: Butorphanol; Heart Rate; Humans; Hydromorphone; Male; Methadone; Morphinans; Naloxone; Opioid-Related Disorders; Pupil; Respiration; Skin Temperature; Substance Withdrawal Syndrome; Surveys and Questionnaires | 1987 |
Irreversible opiate agonists and antagonists. IV. Analgesic actions of 14-hydroxydihydromorphinone hydrazones.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrazones; Hydromorphone; Male; Mice; Naloxone; Oxymorphone; Receptors, Opioid; Time Factors | 1988 |
Sublingual absorption of selected opioid analgesics.
Topics: Administration, Sublingual; Adult; Analgesics, Opioid; Analysis of Variance; Biological Availability; Buprenorphine; Fentanyl; Heroin; Humans; Hydromorphone; Levorphanol; Methadone; Morphine; Mouth; Naloxone; Oxycodone; Time Factors | 1988 |
Effects of oxymorphazone in frogs: long lasting antinociception in vivo, and apparently irreversible binding in vitro.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug; Hydromorphone; Kinetics; Naloxone; Oxymorphone; Rana esculenta; Receptors, Opioid; Spinal Cord | 1989 |
Simultaneous extraction and chromatographic analysis of morphine, dilaudid, naltrexone and naloxone in biological fluids by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Hydromorphone; Male; Morphine; Naloxone; Naltrexone; Rats | 1989 |
Naloxone reversal of oxymorphone effects in dogs.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs; Heart; Heart Rate; Hydromorphone; Naloxone; Oxygen; Oxymorphone; Pulmonary Wedge Pressure; Respiration; Tidal Volume; Vascular Resistance | 1989 |
Comparison of histamine release in human skin mast cells induced by morphine, fentanyl, and oxymorphone.
Topics: Cell Membrane; Dose-Response Relationship, Drug; Fentanyl; Histamine; Histamine Release; Humans; Hydromorphone; Leukocytes; Mast Cells; Morphine; Naloxone; Oxymorphone; Receptors, Opioid; Skin | 1985 |
Chloroacryloyl amides and alpha-methylenelactones from naltrexone, oxymorphone and fentanyl.
Topics: Acrylates; Animals; Binding Sites; Brain; Chemical Phenomena; Chemistry; Fentanyl; Hydromorphone; In Vitro Techniques; Membranes; Naloxone; Naltrexone; Oxymorphone; Rats; Stereoisomerism | 1985 |
Sensitivity of thin-layer chromatography for detection of 16 opioids, cocaine and quinine.
Topics: Alphaprodine; Chromatography, Thin Layer; Cocaine; Codeine; Cyclazocine; Dextropropoxyphene; Humans; Hydromorphone; Levallorphan; Levorphanol; Meperidine; Methadone; Methods; Morphinans; Morphine; Nalorphine; Naloxone; Oxymorphone; Pentazocine; Quinine | 1972 |
Is the uptake of narcotic analgesics by cerebral cortical slices mediated in part by active transport?
Topics: Anaerobiosis; Analgesics; Animals; Antimetabolites; Biological Transport, Active; Cerebral Cortex; Hydromorphone; Male; Nalorphine; Naloxone; Rats; Tritium | 1973 |
Opiate agonists and antagonists discriminated by receptor binding in brain.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Hydromorphone; In Vitro Techniques; Levallorphan; Levorphanol; Mice; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Oxymorphone; Receptors, Drug; Sodium; Tritium | 1973 |
Stereospecific uptake of narcotic analgesics by a subcellular fraction of the guinea-pig ileum. A preliminary communication.
Topics: Analgesics; Animals; Codeine; Dextromoramide; Female; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Intestinal Absorption; Levorphanol; Male; Methadone; Morphine; Muscle, Smooth; Nalorphine; Naloxone; Narcotics; Subcellular Fractions; Tritium | 1973 |
Narcotic receptor sites in morphine-dependent rats.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Drug Tolerance; Female; Humans; Hydromorphone; In Vitro Techniques; Male; Morphinans; Morphine; Morphine Dependence; Naloxone; Physostigmine; Rats; Receptors, Drug; Tritium | 1974 |
Three-choice discrimination in methadone maintenance patients: hydromorphone, naloxone, and saline.
Topics: Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Humans; Hydromorphone; Male; Methadone; Naloxone; Substance-Related Disorders | 1984 |
Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones.
Topics: Analgesics, Opioid; Animals; Brain; Delayed-Action Preparations; Hydrazones; Hydromorphone; In Vitro Techniques; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Receptors, Opioid | 1980 |
Morphine analgesia after intrathecal administration of a narcotic agonist, chloroxymorphamine and antagonist, chlornaltrexamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydromorphone; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone; Rats | 1980 |
Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine.
Topics: Analgesics; Animals; Brain; Hydromorphone; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone | 1980 |
Liver damage from narcotics in mice.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cytochrome P-450 Enzyme System; Drug Tolerance; Female; Hydromorphone; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Morphine; Naloxone; Narcotics; Sex Factors; Species Specificity | 1981 |
Irreversible opiate agonists and antagonists: the 14-hydroxydihydromorphinone azines.
Topics: Animals; Brain; Cell Membrane; Dihydromorphine; Drug Stability; Hydromorphone; Kinetics; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship | 1982 |
Effect of morphinone on opiate receptor binding and morphine-elicited analgesia.
Topics: Analgesia; Animals; Cysteine; Dihydromorphine; Glutathione; Hydromorphone; Kinetics; Mice; Morphine; Naloxone; Receptors, Opioid | 1982 |
Effects of naloxone and its quaternary form on fluid consumption in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Hydromorphone; Injections, Intraperitoneal; Injections, Intraventricular; Male; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains | 1982 |
Cynomolgus monkeys do not develop tolerance to opioids.
Topics: Animals; Drug Tolerance; Humans; Hydromorphone; Macaca fascicularis; Macaca mulatta; Naloxone; Opioid-Related Disorders; Species Specificity | 1983 |
Quaternary opiate antagonists lower blood pressure and inhibit leucine-enkephalin responses.
Topics: Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Heart Rate; Hydromorphone; Naloxone; Naltrexone; Oxymorphone; Quaternary Ammonium Compounds | 1983 |
Fluid consumption in water-deprived rats after administration of naloxone or quaternary naloxone.
Topics: Animals; Drinking; Hydromorphone; Male; Muridae; Naloxone; Oxymorphone; Receptors, Opioid; Taste; Thirst; Water Deprivation | 1983 |
An etorphine-evoked vagal reflex in rats is inhibited by naloxone, N-methylnaloxone, and SMS 201-995.
Topics: Animals; Blood Pressure; Etorphine; Heart Rate; Hydromorphone; Male; Morphinans; Naloxone; Octreotide; Oxymorphone; Rats; Rats, Inbred Strains; Reflex; Respiration; Somatostatin; Vagus Nerve | 1983 |
Local inhibition of inflammatory pain by naloxone and its N-methyl quaternary analogue.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Foot; Hydromorphone; Injections, Subcutaneous; Male; Morphine; Naloxone; Nociceptors; Oxymorphone; Rats; Rats, Inbred Strains | 1983 |
Oxymorphazone: a long-acting opiate analgesic.
Topics: Analgesia; Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Hydromorphone; Injections, Intraventricular; Morphine; Naloxone; Oxymorphone; Rats; Receptors, Opioid; Time Factors | 1984 |
Diastereomeric 6-desoxy-6-spiro-alpha-methylene-gamma-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted michael acceptor liga
Topics: Animals; Brain; Cell Membrane; Chromatography, Thin Layer; Hydromorphone; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Conformation; Naloxone; Naltrexone; Narcotic Antagonists; Optical Rotation; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1984 |
Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study.
Topics: Animals; Cell Division; Codeine; Hydromorphone; Immune System; Immunosuppression Therapy; Interleukin-2; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Oxycodone; Structure-Activity Relationship | 1997 |
Hydrogen cyanide generation by mu-opiate receptor activation: possible neuromodulatory role of endogenous cyanide.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Cricetinae; Female; Hydrogen Cyanide; Hydromorphone; In Vitro Techniques; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Neurotransmitter Agents; PC12 Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Hydromorphone-naloxone combinations in opioid-dependent humans under a naloxone novel-response discrimination procedure.
Topics: Adult; Discrimination Learning; Dose-Response Relationship, Drug; Female; Humans; Hydromorphone; Male; Methadone; Naloxone; Opioid-Related Disorders | 1998 |
Is the analgesic effect of systemic lidocaine mediated through opioid receptors?
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Drug Interactions; Female; Humans; Hydromorphone; Infusions, Intravenous; Lidocaine; Middle Aged; Naloxone; Narcotic Antagonists | 2003 |
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2004 |
Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain.
Topics: Analysis of Variance; Animals; Atropine; Brain; Carbachol; Cells, Cultured; Cholinergic Agonists; Cyanides; Drug Interactions; Embryo, Mammalian; Hydromorphone; Morphine; Muscarinic Agonists; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Narcotics; Oxotremorine; PC12 Cells; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface | 2004 |
Assessment of agonist and antagonist effects of tramadol in opioid-dependent humans.
Topics: Adult; Analgesics, Opioid; Heart Rate; Humans; Hydromorphone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Tramadol | 2006 |
Myoclonus as an acute complication of low-dose hydromorphone in multiple system atrophy.
Topics: Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Hydromorphone; Male; Multiple System Atrophy; Myoclonus; Naloxone; Narcotic Antagonists | 2006 |
Use of naloxone in hydromorphone-induced anaphylactoid reaction.
Topics: Aged; Analgesics, Opioid; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Hydromorphone; Naloxone | 2007 |
Amplification of acute focal ischemic deficit by narcotics.
Topics: Acute Disease; Aged; Brain Ischemia; Female; Humans; Hydrocodone; Hydromorphone; Male; Naloxone; Narcotic Antagonists; Narcotics; Pain, Postoperative | 2008 |
Acute pain control challenges with buprenorphine/naloxone therapy in a patient with compartment syndrome secondary to McArdle's disease: a case report and review.
Topics: Acetaminophen; Acute Pain; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Compartment Syndromes; Creatine Kinase; Drug Combinations; Glycogen Storage Disease Type V; Humans; Hydromorphone; Injections, Intramuscular; Male; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Pain Measurement; Rhabdomyolysis | 2013 |
The Changing Use of Intravenous Opioids in an Emergency Department.
Topics: Adult; Analgesics, Opioid; Drug Utilization; Emergency Service, Hospital; Emergency Treatment; Female; Fentanyl; Humans; Hydromorphone; Infusions, Intravenous; Male; Middle Aged; Morphine; Naloxone; Retrospective Studies; Trauma Centers | 2015 |
A Case of Toxic Breast-feeding?
Topics: Analgesics, Opioid; Breast Feeding; Humans; Hydromorphone; Infant, Newborn; Milk, Human; Mothers; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Postpartum Period | 2019 |
A Multisite Retrospective Study Evaluating the Implementation of the Pasero Opioid-Induced Sedation Scale (POSS) and Its Effect on Patient Safety Outcomes.
Topics: Adult; Aged; Female; Humans; Hydromorphone; Hypnotics and Sedatives; Male; Middle Aged; Naloxone; Narcotic Antagonists; Outcome Assessment, Health Care; Pain Management; Patient Safety; Respiratory Insufficiency; Retrospective Studies | 2017 |
Digital ischaemia after intra-arterial drug injection.
Topics: Buprenorphine; Constriction, Pathologic; Fingers; Humans; Hydromorphone; Injections, Intra-Arterial; Ischemia; Male; Middle Aged; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Peripheral Vascular Diseases; Toes | 2017 |
Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse.
Topics: Analgesics, Opioid; Ascorbic Acid; Dehydroascorbic Acid; Enkephalin, Methionine; Glutathione; Humans; Hydromorphone; Methadone; Morphine; Naloxone; Peptides; Receptors, Adrenergic, beta-2; Receptors, Dopamine D1; Receptors, Histamine H1; Receptors, Opioid; Receptors, Opioid, mu | 2020 |
Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Hydromorphone; Male; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Pain | 2023 |