hydromorphone and hydrocodone

hydromorphone has been researched along with hydrocodone in 84 studies

Research

Studies (84)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (16.67)	18.7374
1990's	10 (11.90)	18.2507
2000's	13 (15.48)	29.6817
2010's	40 (47.62)	24.3611
2020's	7 (8.33)	2.80

Authors

Authors	Studies
Kotick, MP; Leland, DL; Polazzi, JO; Schut, RN	2
Kotick, MP; Leland, DL	2
Herlihy, P; Howes, JF; Quick, J; Razdan, RK	1
Howes, JF; Kotick, MP; Osgood, PF; Polazzi, JO; Razdan, RK; Schut, RN; Villarreal, JE	1
Bousquet, A; Howes, JF; Kotick, MP; Leland, DL; Polazzi, JO	1
Bousquet, AR; Howes, JF; Kotick, MP; Leland, DL; Polazzi, JO	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B	1
Cone, EJ; Darwin, WD	1
Ciancio, SG	1
Honigberg, IL; Stewart, JT	1
Griesemer, EC; Nakamura, GR; Noguchi, TT; Park, JI	1
Ghosh, AC; Herlihy, P; Howes, JF; Lavoie, RL; Razdan, RK	1
Dietzen, DJ; Koenig, J; Turk, J	1
Bruce, NC; Caswell, DA; French, CE; Hailes, AM; Long, MT; Willey, DL	1
Bruce, NC; Hailes, AM	1
Busto, UE; Cheung, SW; Kaplan, HL; Otton, SV; Schadel, M; Sellers, EM	1
Deitermann, D; Leikin, J; Lewis, D; Moore, CM	1
Bruce, NC; French, CE; Hailes, AM; Rathbone, DA	1
Baylon, GJ; Busto, UE; Cheung, SW; Kaplan, HL; Otton, SV; Sellers, EM; Somer, G	1
Bruce, NC; French, CE; Hailes, AM; Long, MT; Rathbone, DA; Willey, DL	1
France, CP; Lelas, S; Otton, SV; Sellers, EM; Wegert, S	1
Bohrer, A; Koenig, J; Nowatzke, W; Saunders, A; Turk, J; Zeng, J	1
Balíková, M; Habrdová, V; Maresová, V	1
Boonstra, B; Bruce, NC; Rathbone, DA	1
Dersch, CM; Jacobson, AE; Marcus, J; Prisinzano, T; Rice, KC; Rothman, RB; Yu, H	1
Chen, YL; Hanson, GD; Jiang, X; Naidong, W	1
Jones, J; Moore, C; Tomlinson, K	1
BOEHME, H; HOCKE, H	1
Coller, JK; Foster, DJ; Hutchinson, MR; Menelaou, A; Somogyi, AA	1
Carroll, PJ; Dalton, DR; Wilson, ML	1
Bu, J; Jiang, Y; Ma, D; Shen, BH; Shen, M; Xiang, P; Zhuo, XY	1
Di Marino, ME; Haddox, JD; Smith, MY	1
Bernstein, RA; Dubow, J	1
Holtman, JR; Lofwall, MR; Nuzzo, PA; Walsh, SL	1
Bailey, JE; Campagna, E; Dart, RC	1
Hunek, C; Jenkins, AJ; Lavins, ES	1
Chronister, CW; Goldberger, BA; Merves, ML	1
Dahn, T; Gunn, J; Kriger, S; Terrell, AR	1
Gingras, M; Laberge, MH; Lefebvre, M	1
Anderson, PO; Lane, JR; Nguyen, N; Rafie, S; Rossi, SS; Sauberan, JB; Stellwagen, LM	1
Alford, I; Shan, X; Tiscione, NB; Yeatman, DT	1
Koren, G	1
French, D; Lynch, K; Wu, A	1
Fitzgerald, RL; Godfrey, RA; Griffin, TL; Herold, DA; Pesce, AJ; West, R; Yun, YM	1
Fine, PG; Webster, LR	1
Atayee, RS; Barakat, NH; Best, BM; Pesce, AJ	1
Bebarta, VS; Valtier, S	1
KuKanich, B; Spade, J	1
Bebarta, VS; Mueck, RL; Valtier, S	1
Black, DL; Cone, EJ; Flegel, RR; Heltsley, R; Lodico, CP; Mitchell, JM	1
Navani, DM; Yoburn, BC	1
Atayee, RS; Best, BM; Ma, JD; Yee, DA	1
Bruera, E; Hui, D; Kwon, JH; Reddy, A; Tanco, K	1
Mazer-Amirshahi, M; Mullins, PM; Pines, JM; Rasooly, I; van den Anker, J	1
Black, RA; Butler, SF; Chilcoat, HD; Coplan, PM; McNaughton, EC; Weber, SE	1
Galanie, S; Smolke, CD; Thodey, K	1
Ihenetu, K; Na, S; Rosano, TG; Swift, TA; Wood, M	1
Black, DL; Cone, EJ; DePriest, AZ; Flegel, R; Heltsley, R; LoDico, C; Mitchell, JM	1
Benitez, ME; KuKanich, B; McMurphy, R; Roush, JK	1
Cipriano, A; Friedman, K; Harris, SC; Kapil, RP; Michels, G; Mondal, SA; Shet, M	1
ElSohly, MA; Godfrey, M; Gul, SW; Gul, W; Stamper, B	1
Baumgartner, MR; Bosshard, MM; Kraemer, T; Madry, MM	1
Nascimento, R; Poklis, A; Wolf, CE	1
Darragh, A; Lee, LA; Marinova, M; Mastrianni, KR; Melendez, C; Ryan, E; Sitasuwan, P	1
Dasgupta, A; Dixon, RB	1
Blackmore, CC; Osborn, SR; Vasilyadis, M; Williams, B; Yu, J	1
Hernandez, NM; Parry, JA; Taunton, MJ	1
Baker, O; Garner, C; Nelson, LS; Poon, SJ; Rodgers, AF; Schuur, JD; Weiner, SG	1
Bynum, ND; Flegel, R; Grabenauer, M; Hayes, ED; Mitchell, JM; Moore, KN; White, RM	1
Doucette, ML; Frattaroli, S; Haring, RS; Shields, WC	1
Basilico, M; Bhashyam, AR; Harris, MB; Heng, M	1
Guevara, M; Hofilena, D; Mikel, C; West, R	1
Agüera, A; Campos-Mañas, MC; Ferrer, I; Sánchez Pérez, JA; Thurman, EM	1
Gaskins, JT; Hosseinnejad, K; Jannetto, P; Jortani, SA; Langman, LL; Stauble, ME; Wu, Y; Yin, T	1
Abrams, R; Ambardekar, A; Kandil, E; Khan, A; Minhajuddin, A; Parikh, M; Williams, T	1
Dani, M; Kennedy, D	1
Atayee, RS; Edmonds, KP; Wen, RY	1
Coulter, C; Garnier, M; Moore, C	1
Bateman, BT; Esposito, DB; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Straub, L; Werler, MM	1
Miksys, S; Novalen, M; Richards, J; Tyndale, RF	1
Cassella-Mclane, G; Choucair, I; Durant, TJS; El-Khoury, JM; Vera, MA; Villalba, CF	1

Reviews

1 review(s) available for hydromorphone and hydrocodone

Article	Year
Engineering novel biocatalytic routes for production of semisynthetic opiate drugs. Biomolecular engineering, 2001, Volume: 18, Issue:2 Topics: 17-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Biotechnology; Catalysis; Drug Design; Escherichia coli; Hydrocodone; Hydromorphone; Models, Chemical; Morphine; Narcotics; Recombinant Proteins	2001

Trials

6 trial(s) available for hydromorphone and hydrocodone

Article	Year
Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1 Topics: Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Humans; Hydrocodone; Hydromorphone; Quinidine; Substance-Related Disorders	1997
The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. Drug and alcohol dependence, 2008, Dec-01, Volume: 98, Issue:3 Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Euphoria; Humans; Hydrocodone; Hydromorphone; Miosis; Oculomotor Muscles; Opioid-Related Disorders; Oxycodone; Prescription Drugs; Psychomotor Performance; Pupil	2008
Prescription opioids. II. Metabolism and excretion patterns of hydrocodone in urine following controlled single-dose administration. Journal of analytical toxicology, 2013, Volume: 37, Issue:8 Topics: Administration, Oral; Adult; Analgesics, Opioid; Chromatography, Liquid; Codeine; Creatinine; Female; Humans; Hydrocodone; Hydrolysis; Hydromorphone; Limit of Detection; Male; Metabolic Clearance Rate; Prescription Drug Misuse; Substance Abuse Detection; Tandem Mass Spectrometry; Tissue Distribution; Young Adult	2013
Prescription Opioids. IV: Disposition of Hydrocodone in Oral Fluid and Blood Following Single-Dose Administration. Journal of analytical toxicology, 2015, Volume: 39, Issue:7 Topics: Analgesics, Opioid; Biotransformation; Chromatography, Liquid; Codeine; Healthy Volunteers; Humans; Hydrocodone; Hydromorphone; Limit of Detection; Predictive Value of Tests; Prescription Drugs; Reproducibility of Results; Saliva; Tandem Mass Spectrometry; Tissue Distribution	2015
Pharmacokinetics of hydrocodone and tramadol administered for control of postoperative pain in dogs following tibial plateau leveling osteotomy. American journal of veterinary research, 2015, Volume: 76, Issue:9 Topics: Acetaminophen; Analgesics, Opioid; Animals; Area Under Curve; Dogs; Half-Life; Hydrocodone; Hydromorphone; Osteotomy; Pain, Postoperative; Tramadol	2015
Effects of paroxetine, a CYP2D6 inhibitor, on the pharmacokinetic properties of hydrocodone after coadministration with a single-entity, once-daily, extended-release hydrocodone tablet. Clinical therapeutics, 2015, Oct-01, Volume: 37, Issue:10 Topics: Adult; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme System; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Hydrocodone; Hydromorphone; Male; Paroxetine; Tablets	2015

Other Studies

77 other study(ies) available for hydromorphone and hydrocodone

Article	Year
Analgesic narcotic antagonists. 1. 8 beta-Alkyl-, 8 beta-acyl-, and 8 beta-(tertiary alcohol)dihydrocodeinones and -dihydromorphinones. Journal of medicinal chemistry, 1980, Volume: 23, Issue:2 Topics: Acetates; Analgesics; Animals; Codeine; Hydrocodone; Hydromorphone; Male; Mice; Morphine; Narcotic Antagonists; Rats; Reaction Time; Structure-Activity Relationship	1980
Analgesic narcotic antagonists. 5. 7,7-Dimethyldihydrocodeinones and 7,7-dimethyldihydromorphinones. Journal of medicinal chemistry, 1981, Volume: 24, Issue:6 Topics: Analgesics, Opioid; Animals; Codeine; Hydrocodone; Hydromorphone; Mice; Narcotic Antagonists; Rats; Structure-Activity Relationship	1981
Novel opiates and antagonists. 4. 7-Alkanoylhydromorphones. Journal of medicinal chemistry, 1982, Volume: 25, Issue:8 Topics: Animals; Chemical Phenomena; Chemistry; Hydromorphone; Mice; Narcotic Antagonists; Narcotics; Reaction Time	1982
Analgesic narcotic antagonists. 2. 8-Alkymorphinan-6-ones. Journal of medicinal chemistry, 1980, Volume: 23, Issue:2 Topics: Acetates; Analgesics; Animals; Haplorhini; Humans; Mice; Morphinans; Morphine Dependence; Narcotic Antagonists; Rats; Reaction Time; Structure-Activity Relationship; Substance Withdrawal Syndrome; Substance-Related Disorders	1980
Analgesic narcotic antagonists. 15. Potent narcotic agonist 7 beta-(arylalkyl)-4,5 alpha-epoxymorphinans. Journal of medicinal chemistry, 1983, Volume: 26, Issue:7 Topics: Analgesics; Indicators and Reagents; Morphinans; Narcotic Antagonists; Structure-Activity Relationship	1983
Analgesic narcotic antagonists. 4. 7-Methyl-N-(cycloalkylmethyl)-3-hydroxymorphinan-6-ones and -isomorphinan-6-ones. Journal of medicinal chemistry, 1980, Volume: 23, Issue:12 Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Humans; Morphinans; Morphine Dependence; Narcotic Antagonists; Substance Withdrawal Syndrome	1980
Analgesic narcotic antagonists. 8. 7 alpha-Alkyl-4,5 alpha-epoxymorphinan-6-ones. Journal of medicinal chemistry, 1981, Volume: 24, Issue:12 Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Codeine; Hydrocodone; In Vitro Techniques; Mice; Narcotic Antagonists; Rats; Reaction Time	1981
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1. Journal of medicinal chemistry, 2019, 11-14, Volume: 62, Issue:21 Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation	2019
Simultaneous determination of hydromorphone, hydrocodone and their 6alpha- and 6beta-hydroxy metabolites in urine using selected ion recording with methane chemical ionization. Biomedical mass spectrometry, 1978, Volume: 5, Issue:4 Topics: Codeine; Humans; Hydrocodone; Hydromorphone; Mass Spectrometry; Methane	1978
8 beta-alkyl-N-cycloalkyl-dihydro-codeinones and -morphinones as analgesic narcotic antagonists. NIDA research monograph, 1979, Volume: 27 Topics: Codeine; Hydrocodone; Hydromorphone; Narcotic Antagonists	1979
Drugs in dentistry. Narcotic analgesics: the opioids. Dental management, 1987, Volume: 27, Issue:8 Topics: Analgesics, Opioid; Dental Care; Humans; Hydrocodone; Hydromorphone; Oxycodone	1987
Radioimmunoassay of hydromorphone and hydrocodone in human plasma. Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:10 Topics: Codeine; Humans; Hydrocodone; Hydromorphone; Radioimmunoassay	1980
Hydromorphone detected in bile following hydrocodone ingestion. Journal of forensic sciences, 1982, Volume: 27, Issue:1 Topics: Adult; Bile; Codeine; Humans; Hydrocodone; Hydromorphone; Male	1982
14-alkoxy dihydrocodeinones, dihydromorphinones, and morphinanones--a new class of narcotic analgesics. NIDA research monograph, 1982, Volume: 41 Topics: Analgesics, Opioid; Animals; Codeine; Hydrocodone; Hydromorphone; Mice; Morphine Derivatives; Nociceptors; Rats	1982
Facilitation of thin-layer chromatographic identification of opiates by derivatization with acetic anhydride or methoxyamine. Journal of analytical toxicology, 1995, Volume: 19, Issue:5 Topics: Acetic Anhydrides; Chromatography, Thin Layer; Codeine; Humans; Hydrocodone; Hydromorphone; Hydroxylamines; Indicators and Reagents; Morphine; Morphine Derivatives; Narcotics; Oxycodone; Oxymorphone	1995
Towards engineering pathways for the synthesis of analgesics and antitussives. Annals of the New York Academy of Sciences, 1994, May-02, Volume: 721 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Amino Acid Sequence; Analgesics; Antitussive Agents; Bacterial Proteins; Base Sequence; Biotransformation; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Genetic Engineering; Hydrocodone; Hydromorphone; Molecular Sequence Data; Morphine; Oxidoreductases; Pseudomonas putida; Sequence Homology, Amino Acid	1994
Biological synthesis of the analgesic hydromorphone, an intermediate in the metabolism of morphine, by Pseudomonas putida M10. Applied and environmental microbiology, 1993, Volume: 59, Issue:7 Topics: Biodegradation, Environmental; Codeine; Hydrocodone; Hydromorphone; Morphine; NAD; Oxidoreductases; Pseudomonas putida	1993
CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone. Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:5 Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Humans; Hydrocodone; Hydromorphone; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; Mutation; Oxidation-Reduction; Phenotype; Reference Values	1993
The detection of hydrocodone in meconium: two case studies. Journal of analytical toxicology, 1995, Volume: 19, Issue:6 Topics: Codeine; Gas Chromatography-Mass Spectrometry; Humans; Hydrocodone; Hydrolysis; Hydromorphone; Infant, Newborn; Meconium; Morphine	1995
Engineering pathways in Escherichia coli for the synthesis of morphine alkaloid analgesics and antitussives. Annals of the New York Academy of Sciences, 1996, Oct-12, Volume: 799 Topics: Alcohol Oxidoreductases; Bacterial Proteins; Biotransformation; Cloning, Molecular; Codeine; Escherichia coli; Hydrocodone; Hydromorphone; Morphine; Oxidoreductases; Plasmids; Pseudomonas putida	1996
Biological production of semisynthetic opiates using genetically engineered bacteria. Bio/technology (Nature Publishing Company), 1995, Volume: 13, Issue:7 Topics: Alcohol Oxidoreductases; Analgesics, Opioid; Bacterial Proteins; Codeine; Escherichia coli; Genetic Engineering; Hydrocodone; Hydromorphone; Morphine; Oxidoreductases; Plasmids; Recombinant Proteins	1995
Inhibitors of cytochrome P450 differentially modify discriminative-stimulus and antinociceptive effects of hydrocodone and hydromorphone in rhesus monkeys. Drug and alcohol dependence, 1999, May-03, Volume: 54, Issue:3 Topics: Analgesics, Opioid; Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Discrimination Learning; Enzyme Inhibitors; Female; Hydrocodone; Hydromorphone; Macaca mulatta; Pain Measurement; Piperidines; Quinidine; Receptors, Opioid, mu	1999
Distinction among eight opiate drugs in urine by gas chromatography-mass spectrometry. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 20, Issue:5 Topics: Codeine; Gas Chromatography-Mass Spectrometry; Humans; Hydrocodone; Hydromorphone; Molecular Structure; Morphine; Morphine Derivatives; Narcotics; Oxycodone; Oxymorphone	1999
[Evaluation of methods of trace analysis of various opiates including hydrocodone and hydromorphone in the blood and urine using gas chromatography-mass spectrometry]. Soudni lekarstvi, 2000, Volume: 45, Issue:1 Topics: Gas Chromatography-Mass Spectrometry; Humans; Hydrocodone; Hydromorphone; Narcotics; Substance Abuse Detection	2000
Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. Bioorganic & medicinal chemistry letters, 2002, Jan-21, Volume: 12, Issue:2 Topics: Hydrocodone; Hydromorphone; Indoles; Receptors, Opioid; Structure-Activity Relationship	2002
Simultaneous determination of hydrocodone and hydromorphone in human plasma by liquid chromatography with tandem mass spectrometric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Mar-25, Volume: 769, Issue:1 Topics: Automation; Calibration; Chromatography, Liquid; Humans; Hydrocodone; Hydromorphone; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2002
The simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, 6-acetylmorphine, and oxycodone in hair and oral fluid. Journal of analytical toxicology, 2002, Volume: 26, Issue:3 Topics: Codeine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Hydrocodone; Hydromorphone; Morphine; Morphine Derivatives; Narcotics; Oxycodone; Reproducibility of Results; Saliva; Substance Abuse Detection	2002
[On the chromatographic evaluation of the purity of dihydromorphinone hydrochloride, dihydrocodeine bitartrate, dihydrocodeinone bitartrate and codeine phosphate. 8. Report on the behavior of alkaloid salt solutions on aluminum oxide columns]. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1960, Volume: 293/65 Topics: Alkaloids; Aluminum Oxide; Chromatography; Codeine; Hydrocodone; Hydromorphone	1960
CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. British journal of clinical pharmacology, 2004, Volume: 57, Issue:3 Topics: Analgesics, Opioid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydrocodone; Hydromorphone; Microsomes, Liver; Oxidation-Reduction	2004
Decoration of the aromatic ring of dihydrocodeinone (hydrocodone) and 14-hydroxydihydrocodeinone (oxycodone). The Journal of organic chemistry, 2005, Aug-05, Volume: 70, Issue:16 Topics: Acids; Bromine; Hydrocodone; Hydromorphone; Iodine; Molecular Structure; Narcotics; Oxycodone	2005
[Determination of opiates in biological human samples by liquid chromatography-tandem mass spectrometry]. Fa yi xue za zhi, 2006, Volume: 22, Issue:1 Topics: Chromatography, Liquid; Codeine; Forensic Medicine; Hair; Humans; Hydrocodone; Hydromorphone; Morphine; Narcotics; Reproducibility of Results; Saliva; Substance Abuse Detection; Tandem Mass Spectrometry	2006
Correlates of nonmedical use of hydromorphone and hydrocodone:results from a national household survey. Journal of pain & palliative care pharmacotherapy, 2007, Volume: 21, Issue:3 Topics: Adolescent; Adult; Analgesics, Opioid; Child; Cross-Sectional Studies; Drug Combinations; Female; Health Behavior; Health Status; Humans; Hydrocodone; Hydromorphone; Male; Opioid-Related Disorders; Prevalence; Socioeconomic Factors; Substance-Related Disorders; United States	2007
Amplification of acute focal ischemic deficit by narcotics. Neurocritical care, 2008, Volume: 8, Issue:3 Topics: Acute Disease; Aged; Brain Ischemia; Female; Humans; Hydrocodone; Hydromorphone; Male; Naloxone; Narcotic Antagonists; Narcotics; Pain, Postoperative	2008
The underrecognized toll of prescription opioid abuse on young children. Annals of emergency medicine, 2009, Volume: 53, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Analgesics, Opioid; Buprenorphine; Child, Preschool; Female; Humans; Hydrocodone; Hydromorphone; Infant; Infant, Newborn; Male; Methadone; Morphine; Oxycodone; Poisoning; Prescription Drugs; United States	2009
Prevalence of dihydrocodeine in hydrocodone positive postmortem specimens. Journal of forensic and legal medicine, 2009, Volume: 16, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Codeine; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydrocodone; Hydromorphone; Male; Middle Aged; Postmortem Changes; Prevalence; Substance Abuse Detection; Young Adult	2009
Quantitation of opioids in blood and urine using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.), 2010, Volume: 603 Topics: Analgesics, Opioid; Codeine; Gas Chromatography-Mass Spectrometry; Humans; Hydrocodone; Hydromorphone; Morphine; Morphine Derivatives; Reproducibility of Results; Solid Phase Extraction	2010
Quantitation of morphine, codeine, hydrocodone, hydromorphone, oxycodone, oxymorphone, and 6-monoacetylmorphine (6-MAM) in urine, blood, serum, or plasma using liquid chromatography with tandem mass spectrometry detection. Methods in molecular biology (Clifton, N.J.), 2010, Volume: 603 Topics: Chromatography, Liquid; Codeine; Humans; Hydrocodone; Hydromorphone; Morphine; Morphine Derivatives; Oxycodone; Oxymorphone; Reproducibility of Results; Tandem Mass Spectrometry	2010
Evaluation of the usefulness of an oxycodone immunoassay in combination with a traditional opiate immunoassay for the screening of opiates in urine. Journal of analytical toxicology, 2010, Volume: 34, Issue:2 Topics: Acetylation; Codeine; False Negative Reactions; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Glucuronidase; Humans; Hydrocodone; Hydromorphone; Immunoassay; Morphine; Opiate Alkaloids; Oxycodone; Oxymorphone; Substance Abuse Detection	2010
Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain. Obstetrics and gynecology, 2011, Volume: 117, Issue:3 Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Humans; Hydrocodone; Hydromorphone; Milk, Human; Pain; Postpartum Period; Pregnancy; Young Adult	2011
Quantitation of opioids in whole blood by electron impact-gas chromatography-mass spectrometry. Journal of analytical toxicology, 2011, Volume: 35, Issue:2 Topics: Analgesics, Opioid; Codeine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydrocodone; Hydromorphone; Morphine; Morphine Derivatives; Oxycodone; Oxymorphone; Substance Abuse Detection	2011
Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain. Obstetrics and gynecology, 2011, Volume: 117, Issue:6 Topics: Analgesics, Opioid; Female; Humans; Hydrocodone; Hydromorphone; Infant, Newborn; Milk, Human; Pain; Postpartum Period	2011
Hydrophilic interaction LC-MS/MS analysis of opioids in urine: significance of glucuronide metabolites. Bioanalysis, 2011, Volume: 3, Issue:23 Topics: Analgesics, Opioid; Chromatography, Liquid; Codeine; Gas Chromatography-Mass Spectrometry; Glucuronides; Humans; Hydrocodone; Hydromorphone; Hydrophobic and Hydrophilic Interactions; Oxycodone; Oxymorphone; Reproducibility of Results; Tandem Mass Spectrometry	2011
Dilute and shoot: analysis of drugs of abuse using selected reaction monitoring for quantification and full scan product ion spectra for identification. Journal of analytical toxicology, 2012, Volume: 36, Issue:2 Topics: Chromatography, Liquid; Cocaine; Humans; Hydrocodone; Hydromorphone; Ions; Methamphetamine; Reproducibility of Results; Signal-To-Noise Ratio; Substance Abuse Detection; Tandem Mass Spectrometry	2012
Overdose deaths demand a new paradigm for opioid rotation. Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:4 Topics: Adult; Analgesics, Opioid; Humans; Hydrocodone; Hydromorphone; Male; Pain Management; Pain, Intractable; Prescription Drug Misuse; Therapeutic Equivalency	2012
Relationship between the concentration of hydrocodone and its conversion to hydromorphone in chronic pain patients using urinary excretion data. Journal of analytical toxicology, 2012, Volume: 36, Issue:4 Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Chronic Pain; Drug Monitoring; Humans; Hydrocodone; Hydromorphone; Reference Values; Reproducibility of Results; Retrospective Studies; Tandem Mass Spectrometry; Time Factors	2012
Excretion profile of hydrocodone, hydromorphone and norhydrocodone in urine following single dose administration of hydrocodone to healthy volunteers. Journal of analytical toxicology, 2012, Volume: 36, Issue:7 Topics: Administration, Oral; Analgesics, Opioid; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Hydromorphone; Limit of Detection; Male; Pain; Solid Phase Extraction; Substance Abuse Detection; Tandem Mass Spectrometry	2012
Pharmacokinetics of hydrocodone and hydromorphone after oral hydrocodone in healthy Greyhound dogs. Veterinary journal (London, England : 1997), 2013, Volume: 196, Issue:2 Topics: Acetaminophen; Animals; Area Under Curve; Dogs; Drug Combinations; Half-Life; Hydrocodone; Hydromorphone	2013
Quantitative method for analysis of hydrocodone, hydromorphone and norhydrocodone in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Apr-15, Volume: 925 Topics: Chromatography, Liquid; Drug Stability; Humans; Hydrocodone; Hydromorphone; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2013
In vivo activity of norhydrocodone: an active metabolite of hydrocodone. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 347, Issue:2 Topics: Analgesics, Opioid; Animals; Binding, Competitive; Hydrocodone; Hydromorphone; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Ligands; Male; Mice; Mice, Inbred Strains; Pain; Protein Binding; Receptors, Opioid, mu; Seizures	2013
Observations on the urine metabolic profile of codeine in pain patients. Journal of analytical toxicology, 2014, Volume: 38, Issue:2 Topics: Analgesics, Opioid; Biotransformation; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Monitoring; Enzyme Inhibitors; Humans; Hydrocodone; Hydromorphone; Pain; Retrospective Studies; Risk Assessment; Risk Factors; Urinalysis	2014
Chemical coping versus pseudoaddiction in patients with cancer pain. Palliative & supportive care, 2014, Volume: 12, Issue:5 Topics: Adaptation, Psychological; Adult; Analgesics, Opioid; Comorbidity; Head and Neck Neoplasms; Humans; Hydrocodone; Hydromorphone; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Opioid-Related Disorders; Pain	2014
Rising opioid prescribing in adult U.S. emergency department visits: 2001-2010. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2014, Volume: 21, Issue:3 Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Emergency Service, Hospital; Female; Health Care Surveys; Humans; Hydrocodone; Hydromorphone; Male; Middle Aged; Morphine; Oxycodone; Pain; Pain Measurement; Patient Discharge; Practice Patterns, Physicians'; United States	2014
Monitoring of internet forums to evaluate reactions to the introduction of reformulated OxyContin to deter abuse. Journal of medical Internet research, 2014, May-02, Volume: 16, Issue:5 Topics: Acetaminophen; Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Combinations; Humans; Hydrocodone; Hydromorphone; Internet; Opioid-Related Disorders; Oxycodone; Social Media	2014
A microbial biomanufacturing platform for natural and semisynthetic opioids. Nature chemical biology, 2014, Volume: 10, Issue:10 Topics: Bacterial Proteins; Codeine; Gene Dosage; Gene Expression; Hydrocodone; Hydromorphone; Metabolic Engineering; Metabolic Networks and Pathways; Morphine; Oxycodone; Papaver; Plant Proteins; Pseudomonas putida; Saccharomyces cerevisiae; Thebaine	2014
Multi-drug and metabolite quantification in postmortem blood by liquid chromatography-high-resolution mass spectrometry: comparison with nominal mass technology. Journal of analytical toxicology, 2014, Volume: 38, Issue:8 Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Chromatography, Liquid; Citalopram; Cocaine; Codeine; Dextromethorphan; Diphenhydramine; Evaluation Studies as Topic; Forensic Pathology; Humans; Hydrocodone; Hydromorphone; Meperidine; Methadone; Morphine; Oxycodone; Oxymorphone; Pyrrolidines; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry	2014
LC-MS-MS Method for Analysis of Opiates in Wastewater During Football Games II. Journal of analytical toxicology, 2016, Volume: 40, Issue:5 Topics: Analgesics, Opioid; Chromatography, Liquid; Codeine; Football; Humans; Hydrocodone; Hydromorphone; Morphine; Opiate Alkaloids; Oxycodone; Oxymorphone; Substance Abuse Detection; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical	2016
Hair analysis for opiates: hydromorphone and hydrocodone as indicators of heroin use. Bioanalysis, 2016, Volume: 8, Issue:9 Topics: Analgesics, Opioid; Chromatography, Liquid; Female; Hair; Heroin; Heroin Dependence; Humans; Hydrocodone; Hydromorphone; Male; Morphine; Morphine Derivatives; Opiate Alkaloids; Substance Abuse Detection; Tandem Mass Spectrometry	2016
Evaluation of a Newly Formulated Enzyme Immunoassay for the Detection of Hydrocodone and Hydromorphone in Pain Management Compliance Testing. Journal of analytical toxicology, 2016, Volume: 40, Issue:8 Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Hydrocodone; Hydromorphone; Immunoenzyme Techniques; Opiate Alkaloids; Pain Management; Sensitivity and Specificity; Specimen Handling; Substance Abuse Detection; Tandem Mass Spectrometry	2016
Degradation of Opioids and Opiates During Acid Hydrolysis Leads to Reduced Recovery Compared to Enzymatic Hydrolysis. Journal of analytical toxicology, 2016, Volume: 40, Issue:8 Topics: Analgesics, Opioid; Chromatography, Liquid; Codeine; Cytochrome P-450 CYP2D6; Glucuronidase; Humans; Hydrocodone; Hydrolysis; Hydromorphone; Morphine; Morphine Derivatives; Opiate Alkaloids; Oxycodone; Oxymorphone; Specimen Handling; Tandem Mass Spectrometry	2016
Suitability of the DRI Hydrocodone/Hydromorphone Immunoassay in the Clinical Environment at a Lower Cutoff: Validation With LC-MS/MS Analysis. Therapeutic drug monitoring, 2016, Volume: 38, Issue:6 Topics: Analgesics, Opioid; Chromatography, Liquid; Humans; Hydrocodone; Hydromorphone; Immunoassay; Oxycodone; Oxymorphone; Sensitivity and Specificity; Substance Abuse Detection; Tandem Mass Spectrometry	2016
Changes in Provider Prescribing Patterns After Implementation of an Emergency Department Prescription Opioid Policy. The Journal of emergency medicine, 2017, Volume: 52, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Codeine; Drug Prescriptions; Emergency Service, Hospital; Female; Humans; Hydrocodone; Hydromorphone; Male; Middle Aged; Organizational Policy; Practice Patterns, Physicians'; Quality Improvement; United States	2017
Patients at Risk: Large Opioid Prescriptions After Total Knee Arthroplasty. The Journal of arthroplasty, 2017, Volume: 32, Issue:8 Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Drug Combinations; Drug Prescriptions; Female; Follow-Up Studies; Humans; Hydrocodone; Hydromorphone; Knee Joint; Male; Middle Aged; Morphine; Opioid-Related Disorders; Oxycodone; Pain, Postoperative; Patient Discharge; Reoperation; Retrospective Studies	2017
The Effect of Opioid Prescribing Guidelines on Prescriptions by Emergency Physicians in Ohio. Annals of emergency medicine, 2017, Volume: 70, Issue:6 Topics: Adult; Analgesics, Opioid; Codeine; Emergency Service, Hospital; Female; Guideline Adherence; Humans; Hydrocodone; Hydromorphone; Male; Middle Aged; Ohio; Oxycodone; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tramadol	2017
Development of a Quantitative LC-MS-MS Assay for Codeine, Morphine, 6-Acetylmorphine, Hydrocodone, Hydromorphone, Oxycodone and Oxymorphone in Neat Oral Fluid. Journal of analytical toxicology, 2018, Jul-01, Volume: 42, Issue:6 Topics: Analgesics, Opioid; Calibration; Chromatography, Liquid; Codeine; Humans; Hydrocodone; Hydromorphone; Morphine; Morphine Derivatives; Opioid-Related Disorders; Oxycodone; Oxymorphone; Predictive Value of Tests; Reference Standards; Reproducibility of Results; Saliva; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry	2018
Storing and Disposing of Opioid Analgesics: What Does Our Medicine Tell Us? Annals of internal medicine, 2018, 08-07, Volume: 169, Issue:3 Topics: Analgesics, Opioid; Drug Labeling; Drug Storage; Fentanyl; Humans; Hydrocodone; Hydromorphone; Medical Waste Disposal; Morphine; Oxycodone; Prescription Drug Diversion; Safety; Tramadol	2018
Prescription Opioid Type and the Likelihood of Prolonged Opioid Use After Orthopaedic Surgery. The Journal of the American Academy of Orthopaedic Surgeons, 2019, May-01, Volume: 27, Issue:9 Topics: Analgesics, Opioid; Drug Utilization; Female; Humans; Hydrocodone; Hydromorphone; Male; Morphine; Musculoskeletal System; Orthopedic Procedures; Patient Discharge; Prescriptions; Therapeutic Equivalency; Time Factors	2019
Positivity rates of drugs in patients treated for opioid dependence with buprenorphine: A comparison of oral fluid and urine using paired collections and LC-MS/MS. Drug and alcohol dependence, 2018, 12-01, Volume: 193 Topics: Buprenorphine; Cannabinoids; Chromatography, Liquid; Humans; Hydrocodone; Hydromorphone; Illicit Drugs; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Oxymorphone; Retrospective Studies; Saliva; Substance Abuse Detection; Tandem Mass Spectrometry	2018
Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis. The Science of the total environment, 2019, May-10, Volume: 664 Topics: Analgesics, Opioid; Chromatography, Liquid; Codeine; Data Analysis; Environmental Monitoring; Fentanyl; Heroin; Hydrocodone; Hydromorphone; Minnesota; Morphine; Morphine Derivatives; Oxycodone; Retrospective Studies; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol; Wastewater; Water Pollutants, Chemical	2019
Lack of Influence by CYP3A4 and CYP3A5 Genotypes on Pain Relief by Hydrocodone in Postoperative Cesarean Section Pain Management. The journal of applied laboratory medicine, 2019, Volume: 3, Issue:6 Topics: Analgesics, Opioid; Biomarkers, Pharmacological; Cesarean Section; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Female; Humans; Hydrocodone; Hydromorphone; Pain Management; Pain, Postoperative; Pharmacogenomic Testing; Polymorphism, Genetic	2019
Opioid prescribing practices in a pediatric burn tertiary care facility: Is it time to change? Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:1 Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adolescent; Ambulatory Care; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Conduction; Burn Units; Burns; Child; Child, Preschool; Codeine; Drug Combinations; Female; Fentanyl; Hospitalization; Humans; Hydrocodone; Hydromorphone; Infant; Length of Stay; Male; Morphine; Pain Management; Patient Discharge; Practice Patterns, Physicians'; Retrospective Studies; Tertiary Care Centers; Tramadol	2020
Comparative Analysis of ELISA Immunoassay and LC-QTOF for Opiate Screening. Journal of analytical toxicology, 2020, May-18, Volume: 44, Issue:4 Topics: Analgesics, Opioid; Chromatography, Liquid; Codeine; Enzyme-Linked Immunosorbent Assay; Humans; Hydrocodone; Hydromorphone; Morphine; Morphine Derivatives; Oxycodone; Oxymorphone; Substance Abuse Detection	2020
A Comparison of Institutional Opioid Equianalgesia Tools: A National Study. Journal of palliative medicine, 2022, Volume: 25, Issue:11 Topics: Administration, Oral; Analgesics, Opioid; Fentanyl; Humans; Hydrocodone; Hydromorphone; Levorphanol; Morphine; Oxycodone; Tapentadol; Tramadol	2022
Rapid Extraction and Qualitative Screening of 30 Drugs in Oral Fluid at Concentrations Recommended for the Investigation of DUID Cases. Journal of analytical toxicology, 2022, Oct-14, Volume: 46, Issue:8 Topics: 2-Propanol; 3,4-Methylenedioxyamphetamine; Alprazolam; Amphetamines; Buprenorphine; Carisoprodol; Clonazepam; Cocaine; Codeine; Dronabinol; Fentanyl; Hexanes; Hydrocodone; Hydromorphone; Lorazepam; Meprobamate; Methadone; Methamphetamine; Morphine Derivatives; N-Methyl-3,4-methylenedioxyamphetamine; Nordazepam; Oxazepam; Oxycodone; Oxymorphone; Pharmaceutical Preparations; Phencyclidine; Tandem Mass Spectrometry; Temazepam; Tramadol; Zolpidem	2022
Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns. JAMA network open, 2022, 08-01, Volume: 5, Issue:8 Topics: Adult; Analgesics, Opioid; Codeine; Cohort Studies; Female; Humans; Hydrocodone; Hydromorphone; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Morphine; Neonatal Abstinence Syndrome; Oxycodone; Pain; Pregnancy; Prescriptions; Substance Withdrawal Syndrome; Tramadol; United States	2022
CYP2D in the brain impacts oral hydrocodone analgesia in vivo. Neuropharmacology, 2022, 12-15, Volume: 221 Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Hydrocodone; Hydromorphone; Male; Pain; Propranolol; Rats; Rats, Wistar; Tandem Mass Spectrometry	2022
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical biochemistry, 2023, Volume: 112 Topics: Analgesics, Opioid; Chromatography, Liquid; Humans; Hydrocodone; Hydromorphone; Opioid-Related Disorders; Oxycodone; Oxymorphone; Tandem Mass Spectrometry	2023