Compounds > hydrogen sulfide

hydrogen sulfide and gyy 4137

hydrogen sulfide has been researched along with gyy 4137 in 126 studies

Research

Studies (126)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (1.59)29.6817
2010's90 (71.43)24.3611
2020's34 (26.98)2.80

Authors

AuthorsStudies
Baskar, R; Cheng, Y; Guan, YY; Lee, SW; Li, L; Moore, PK; Neo, KL; Tan, CH; Whiteman, M; Zhao, Y1
Li, L; Moore, PK; Salto-Tellez, M; Tan, CH; Whiteman, M1
Li, L; Moore, PK; Parkinson, DB; Rose, P; Tan, CH; Whiteman, M1
Geng, B; Tang, CS; Yu, F; Zhao, J1
Civale, L; Hancock, JT; Lewandowski, K; Lisjak, M; Srivastava, N; Teklic, T; Whiteman, M; Wilson, I; Wood, ME1
Adcock, I; Chung, KF; Hui, CK; Kirkham, P; Michaeloudes, C; Perry, MM; Whiteman, M; Wood, ME1
Chen, CS; Deng, LW; Lee, ZW; Li, L; Moore, PK; Tan, CH; Zhao, Y; Zhou, J1
Hancock, JT; Lisjak, M; Teklić, T; Whiteman, M; Wilson, ID; Wood, M1
Garrett, N; Moger, J; Whiteman, M1
Borea, PA; Fazzi, D; Gessi, S; Merighi, S; Varani, K1
Robinson, H; Wray, S1
Fox, B; Keeble, J; Li, L; Moore, PK; Salto-Tellez, M; Whiteman, M; Winyard, PG; Wood, ME1
Barahona, MV; Bustamante, S; Carballido, J; Fernandes, VS; García-Sacristán, A; Hernández, M; Martínez, AC; Martínez-Sáenz, A; Orensanz, LM; Prieto, D; Recio, P; Ribeiro, AS1
Li, ZG; Long, WB; Shen, ZZ; Yang, GX; Yang, SZ1
DellaValle, B; Hempel, C; Kurtzhals, JA; Staalsoe, T1
Kashfi, K1
Csaderova, L; Hudecova, S; Krizanova, O; Lencesova, L; Markova, J; Ondrias, K; Pastorek, M; Sedlak, J; Soltysova, A; Whiteman, M; Wood, ME1
Delyagina, E; Frank, M; Grambow, E; Kuhla, A; Mueller-Graf, F; Vollmar, B1
Antelmann, H; Bäsell, K; Becher, D; Dick, TP; Greiner, R; Nagy, P; Pálinkás, Z1
Ahmad, S; Ahmed, A; Baily, J; Buhimschi, CS; Buhimschi, IA; Cai, M; Crispi, F; Cudmore, M; Fujisawa, T; Gratacós, E; Hadoke, PW; Miller, MR; Rennie, J; Wang, K; Wang, R1
Feng, J; Guo, Q; Han, Y; Luo, Y; Tan, G; Tang, H; Xiong, H; Yang, C; Zeng, F1
Cai, B; Cui, QH; Fan, X; Geng, B; Gong, Y; Liao, F; Tang, C; Xu, GH; Yang, J; Zeng, Q; Zheng, Y1
Dymock, BW; Gruber, J; Halliwell, B; Kumar, SD; Li, L; Moore, PK; Ng, LF; Peh, MT; Qabazard, B; Rose, P; Stürzenbaum, SR; Swain, SC; Tan, CH; Wei, F1
Chitnis, MK; Njie-Mbye, YF; Ohia, SE; Opere, CA; Whiteman, M; Wood, ME1
Ahmed, S; Arlt, VM; Li, L; Moore, PK; Qabazard, B; Stürzenbaum, SR1
Hu, X; Li, WD; Liao, LZ; Wei, WB; Zhuang, XD1
Liu, P; Liu, Z; Xu, S1
Fehrenbach, H; Herold, S; Madurga, A; Mayer, K; Mižíková, I; Morty, RE; Ruiz-Camp, J; Seeger, W; Vadász, I1
Alphonse, RS; Eaton, F; Haromy, A; Ionescu, L; Machado, DS; Michelakis, ED; O'Reilly, M; Thébaud, B; Vadivel, A1
An, SS; Chan-Li, Y; DeSantiago, B; Fitzgerald, R; Foster, DB; Horton, MR; Kim, JY; Lee, DY; Panettieri, RA; Wang, R; Yang, G1
Duan, GL; Li, XH; Liu, YJ; Ni, X; Wang, CN; Zhao, W; Zhu, XY1
Deng, LW; Hagen, T; Lee, ZW; Moore, PK; Tan, CH; Tay, EY; Teo, XY1
Blanco, FJ; Burguera, EF; Magalhães, J; Meijide-Faílde, R; Vela-Anero, A1
Du, Q; Lin, W; Liu, Y; Peng, H; Wu, Z1
Barahona, MV; Benedito, S; Bustamante, S; Fernandes, VS; García-Sacristán, A; Hernández, M; López-Oliva, ME; Martínez, P; Martínez-Sáenz, A; Orensanz, LM; Prieto, D; Recio, P; Ribeiro, AS1
Chen, Y; Fan, X; Jiang, X; Lu, K; Zhang, H1
Dymock, BW; Moore, PK; Rose, P1
Casola, A; Coletta, C; Escaffre, O; Garofalo, RP; Ivanciuc, T; Kelley, JP; Komaravelli, N; Li, H; Ma, Y; Rockx, B; Szabo, C1
Paul, BD; Snyder, SH1
Dymock, BW; Feng, W; Moore, PK; Peh, MT; Tsai, CY1
Fernandes, VS; Petkov, GV; Xin, W1
Kwong, RW; Perry, SF1
Akaike, T; Honda, K; Ihara, H; Iwai, S; Sawa, T; Yamada, N; Yoshida, R1
Cao, YJ; Cheng, J; Du, HP; Hu, LF; Li, JJ; Li, Q; Liu, CF; Wang, F; Wang, YL; Xu, XS; You, SJ1
Dong, S; Li, T; Lu, F; Wang, L; Wu, J; Xu, C; Yang, F; Yu, X; Zhang, W; Zhao, Y; Zheng, D; Zhong, X1
Bucci, M; Cirino, G; Papapetropoulos, A; Perry, A; Whiteman, M; Wood, ME; Zhou, Z1
Pacheco, A; Xian, M; Zhao, Y1
Liew, OW; Lilyanna, S; Martinez, EC; Moore, PK; Peh, MT; Richards, AM; Wang, P1
Beaman, KD; Candela, J; Huang, H; Jaiswal, MK; Prakriya, M; Sun, H; Velmurugan, GV; White, C; Yamashita, M1
Bankhele, P; Jamil, JM; Kulkarni-Chitnis, M; Njie-Mbye, YF; Ohia, SE; Opere, CA; Salvi, A1
Han, P; Liu, B; Ma, L; Sun, X; Tan, G; Tang, B; Yao, X; Yu, T1
Hudecova, S; Krizanova, O; Lencesova, L; Vlcek, M1
Candela, J; Velmurugan, GV; White, C1
Babula, P; Csaderova, L; Hudecova, S; Krizanova, O; Kubickova, J; Lencesova, L; Lichvarova, L; Soltysova, A1
Habara, Y; Moustafa, A1
Haig, A; Jiang, J; Lian, D; Lin, S; Liu, W; Lobb, I; Mok, A; Sener, A; Torregrossa, R; Visram, F; Whiteman, M; Wood, ME1
Ferro, A; Gu, Y; Han, Y; Huang, Z; Ji, Y; Liu, G; Ma, Y; Meng, G; Moore, PK; Wang, H; Wang, W; Wang, X; Wang, Y; Wen, M; Xie, L; Yu, Y; Zhang, Z; Zhao, S1
Jia, Z; Liu, M; Sun, Y; Yang, T; Zhang, A1
Baxter, GF; Karwi, QG; Torregrossa, R; Whiteman, M; Wood, ME1
Ji, F; Yan, R; Zhang, B; Zhao, H; Zhou, X1
Blanco, FJ; Burguera, EF; Meijide-Failde, R1
Ferro, A; Gu, Y; Han, Y; Ji, Y; Liu, J; Ma, Y; Meng, G; Moore, PK; Park, CM; Tang, X; Wang, H; Wang, R; Wang, X; Xian, M; Xiao, Y; Xie, L; Yu, Y; Zhang, Z1
Frank, M; Grambow, E; Klar, E; Kundt, G; Leppin, C; Leppin, K; Vollmar, B1
Juman, S; Miki, T; Nara, Y; Negishi, H; Okuda, H; Takado, N; Yasui, N1
Duan, GL; Liu, SJ; Liu, YJ; Ni, X; Tang, XL; Wang, CN; Zhang, HX; Zhu, XY1
Bazhanov, N; Casola, A; Escaffre, O; Freiberg, AN; Garofalo, RP1
Calzia, E; Georgieff, M; Gröger, M; Hafner, S; Matallo, J; McCook, O; Nußbaum, BL; Radermacher, P; Vogt, J; Wachter, U; Wepler, M; Whiteman, M; Wood, ME1
Bu, D; Chen, S; Du, J; Huang, Y; Jin, H; Sun, Y; Tang, C; Yao, Q; Yu, W; Zhang, C1
Drapala, A; Grman, M; Koszelewski, D; Ondrias, K; Ostaszewski, R; Tomasova, L; Ufnal, M1
Fordham, M; John, AMSP; Kundu, S; Mukhopadhyay, M; Pushpakumar, S; Sen, U; Weber, G1
Fynn-Sackey, N; Gagnon, J; Pichette, J1
Anders, F; Grus, FH; Liu, A; Liu, H; Mann, C; Pfeiffer, N; Prokosch-Willing, V; Thanos, S1
Juriasingani, S; Lin, S; Sener, A1
Du, J; Guo, L; Li, J; Liu, Y; Wang, S; Zhuang, R1
Du, J; Du, S; Li, D; Liu, Y; Ni, X; Wang, C; Zhu, X1
Ahn, YJ; Kim, SH; Lee, GJ; Park, BM; Yu, L1
Baraibar, AM; de Diego, AMG; de Pascual, R; Gandía, L; García, AG; Méndez-López, I; Ohia, SE; Pérez-Ciria, M; Polo-Vaquero, I1
Bazhanov, N; Casola, A; Garofalo, M; Ivanciuc, T; Kang, J; Wu, H; Xian, M1
Augustin, VA; Grambow, E; Klar, E; Kundt, G; Strüder, D; Vollmar, B1
Aratake, T; Higashi, Y; Nakamura, K; Ono, H; Saito, M; Shimizu, S; Shimizu, T; Zou, S1
Cao, J; Lippert, AR; Wilson, JJ; Woods, JJ1
Drucker, NA; Jensen, AR; Markel, TA; Te Winkel, JP1
Bowden, NB; Brown, EM; Carter, JM; Grace, JP; Irish, EE; Salem, AK1
Bian, J; Cao, X; Moore, PK; Zhang, W1
Cui, X; Ding, W; Jiang, T; Liu, T; Liu, Y; Lv, X; Meng, Q; Yue, Z1
Babula, P; Cholujova, D; Chovancova, B; Hudecova, S; Krizanova, O; Lencesova, L; Matuskova, M; Ondrias, K; Szadvari, I; Valerian, D1
He, B; He, G; Li, L; Yang, M; Yang, X; Yin, X; Zhang, K; Zhang, X; Zhang, Z1
Abecia, L; Forcén, R; Grasa, L; Latorre, E; Layunta, E; Mesonero, JE; Peña-Cearra, A; Robles, S1
Castells-Nobau, A; Comas, F; Costas, M; Cussó, O; Fernández-Real, JM; Latorre, J; Lluch, A; Moreno-Navarrete, JM; Ortega, F; Ribas, X; Ricart, W; Sabater, M1
Chimini, JS; da Silva, MLS; Dias-Junior, CA; Possomato-Vieira, JS; Zochio, GP1
Bowden, NB; Brown, EM; Carter, JM; Irish, EE1
Deng, LW; Idres, SB; Moore, PK; Nin, DS; Song, ZJ1
Adiraj Iyer, M; Eddington, D1
Gao, S; Li, C; Yin, L1
Grambow, E; Klar, E; Klee, G; Vollmar, B1
Cui, N; Luo, H; Zhao, Y1
Chuvakova, LN; Evgen'ev, MB; Funikov, SY; Krasnov, GS; Kulikova, DA; Morozov, AV; Rezvykh, AP; Vinokurov, MG; Yurinskaya, MM; Zatsepina, OG1
Cao, S; Chen, H; Gao, Y; Gu, Y; Han, Y; Ji, Y; Miao, Q; Pu, J; Song, T; Wang, H; Xie, L; Zhang, L; Zhang, X; Zhang, Y; Zhao, S1
Jovičić, M; Kadlec, M; Pintus, E; Ros-Santaella, JL1
Blanco, FJ; Burguera, EF; Fernández-Rodríguez, JA; Filgueira-Fernández, P; Hermida-Gómez, T; Meijide-Faílde, R; Vaamonde-García, C; Vela-Anero, Á1
Li, P; Song, P; Wan, GR; Wang, QQ; Wu, ZQ; Xu, J; Yin, YL; Zhao, FR; Zhu, ML; Zhu, TT1
Cai, X; Lai, X; Li, S; Li, X; Liu, J; Liu, X; Ma, J; Shen, Y; Tu, W; Wei, M; Yu, P; Zhang, J; Zhang, Q; Zhu, W1
Kowluru, RA; Mohammad, G; Radhakrishnan, R1
Hua, Y; Ni, K1
Chen, G; Wu, J; Yang, D; Yang, F; Yin, L; Zhang, X; Zou, J1
Geng, B; Hu, J; Liao, F; Xiao, C; Yuan, J; Zhu, Z1
Al-Owais, MM; Boyle, JP; Dallas, ML; Hettiarachchi, NT; Jarosz-Griffiths, HH; Peers, C; Scragg, JL; Steele, D; Vandiver, MS1
Chen, J; Cui, W; He, M; Liu, W; Yu, F1
Hou, XO; Hu, LF; Li, Q; Liu, CF; Qian, HC; Tu, HY; Wang, F; Wang, YL; Xu, GQ; Yang, YP1
Agrawal, R; Murthy, DTN; Pal, VK; Rakshit, S; Shekar, P; Singh, A; Vyakarnam, A1
Caliendo, G; Corvino, A; Esposito, G; Fiorino, F; Frecentese, F; Magli, E; Migliaccio, M; Perissutti, E; Santagada, V; Scognamiglio, A; Severino, B; Sparaco, R1
Li, J; Li, L; Li, M; Ma, J; Yao, C; Yao, S1
Babula, P; Chovancova, B; Kajsik, M; Krizanova, O; Liskova, V1
Han, Y; Lu, Q; Qian, H; Zheng, N; Zhou, T1
Aydemir, BG; Berenyiova, A; Cacanyiova, S; Cebova, M; Golas, S; Majzunova, M1
Hou, C; Jia, S; Jiang, Y; Li, D; Ling, S; Liu, H; Liu, X; Liu, Y; Wang, H; Wang, X; Wang, YF1
Dong, Q; Duan, SF; Han, JG; Ji, XY; Li, T; Liu, W; Wu, DD; Yang, B; Yu, HL; Zhang, MM; Zhang, SH; Zhang, X; Zhang, XJ1
Badiei, A; Cornwell, A; Cowan, S; Fedotova, S1
Lai, H; Liu, W; Liu, Y; Su, W; Xu, Z; Zhou, T1
Efe, OE; Emre Aydıngöz, S; Erdem, ŞR; Kibaroğlu, S; Orhan, HG; Teimoori, A1
Borriello, M; Cohen, G; Farahat, S; Kainz, A; Kherkheulidze, S; Nopp, S; Perna, AF1
Blanco, FJ; F-Burguera, E; Fernández-Rodríguez, JA; Lendoiro-Cino, N; Meijide-Faílde, R; Rodríguez-Coello, A; Saborido, A; Vaamonde-García, C1
Chapel, M; Garle, M; Harper, A; Hodgson, G; Malinowski, K; Ralevic, V; Yates, I1
Geng, Q; Li, L; Meng, J; Miao, Y; Tian, D; Wang, R; Wu, Y; Xu, M; Xue, H; Zhang, X1
Brokaw, JP; Hosfield, BD; Hunter, CE; Liu, J; Manohar, K; Markel, TA; Mesfin, FM; Pecoraro, AR; Shelley, WC1
Lee, CT; Lee, YT; Liu, CH; Ng, HY; Wang, Y; Zhong, HR1

Reviews

11 review(s) available for hydrogen sulfide and gyy 4137

ArticleYear
Anti-cancer activity of new designer hydrogen sulfide-donating hybrids.
    Antioxidants & redox signaling, 2014, Feb-10, Volume: 20, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Hydrogen Sulfide; Morpholines; Neoplasms; Organothiophosphorus Compounds; Reactive Oxygen Species; Signal Transduction

2014
Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis.
    International journal of cardiology, 2014, Mar-15, Volume: 172, Issue:2

    Topics: Animals; Atherosclerosis; Carbon Dioxide; Cystathionine gamma-Lyase; Humans; Hydrogen Sulfide; Mice; Morpholines; Nitric Oxide; Organothiophosphorus Compounds; Oxidative Stress; Signal Transduction

2014
GYY4137, a novel water-soluble, H2S-releasing molecule.
    Methods in enzymology, 2015, Volume: 554

    Topics: Animals; Humans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Solubility; Vasodilator Agents; Water

2015
Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors.
    Handbook of experimental pharmacology, 2015, Volume: 230

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cytoprotection; Humans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds

2015
Medicinal Chemistry: Insights into the Development of Novel H2S Donors.
    Handbook of experimental pharmacology, 2015, Volume: 230

    Topics: Chemistry, Pharmaceutical; Garlic; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Sulfides; Thiones; Thiophenes

2015
Hydrogen Sulfide and Inflammatory Joint Diseases.
    Current drug targets, 2017, Volume: 18, Issue:14

    Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Clinical Trials as Topic; Disease Models, Animal; Humans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Osteoarthritis; Sulfides; Treatment Outcome

2017
Is hydrogen sulfide a potential novel therapy to prevent renal damage during ureteral obstruction?
    Nitric oxide : biology and chemistry, 2018, 02-28, Volume: 73

    Topics: Animals; Carbon Monoxide; Disease Models, Animal; Fibrosis; Gasotransmitters; Humans; Hydrogen Sulfide; Kidney; Male; Morpholines; Nitric Oxide; Organothiophosphorus Compounds; Ureteral Obstruction

2018
Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity.
    International journal of molecular sciences, 2019, Jan-14, Volume: 20, Issue:2

    Topics: Cisplatin; Cystathionine gamma-Lyase; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Sulfide; Kidney; Kidney Diseases; Morpholines; Neoplasms; Organothiophosphorus Compounds; Oxidation-Reduction; Reactive Oxygen Species; Smell

2019
Biological Effects of Morpholin-4-Ium 4 Methoxyphenyl (Morpholino) Phosphinodithioate and Other Phosphorothioate-Based Hydrogen Sulfide Donors.
    Antioxidants & redox signaling, 2020, 01-10, Volume: 32, Issue:2

    Topics: Animals; Humans; Hydrogen Sulfide; Molecular Structure; Morpholines; Organothiophosphorus Compounds; Phosphorothioate Oligonucleotides; Structure-Activity Relationship

2020
H
    Biomolecules, 2021, 12-18, Volume: 11, Issue:12

    Topics: Animals; Benzenesulfonates; Chemistry, Pharmaceutical; Drug Discovery; Gasotransmitters; Humans; Hydrogen Sulfide; Morpholines; Naproxen; Organothiophosphorus Compounds

2021
Effect of hydrogen sulfide on ischemia-reperfusion injury of kidney: A systematic review and meta-analysis of in vivo animal studies.
    European journal of pharmacology, 2023, Mar-15, Volume: 943

    Topics: Animals; Creatinine; Hydrogen Sulfide; Kidney; Reperfusion Injury

2023

Other Studies

115 other study(ies) available for hydrogen sulfide and gyy 4137

ArticleYear
Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.
    Circulation, 2008, May-06, Volume: 117, Issue:18

    Topics: Animals; Antihypertensive Agents; Aorta; Cells, Cultured; Delayed-Action Preparations; Hydrogen Sulfide; Male; Morpholines; Organothiophosphorus Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Solubility; Vasodilator Agents; Water

2008
GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.
    Free radical biology & medicine, 2009, Jul-01, Volume: 47, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Cell Line; Cyclooxygenase 2; Cytokines; Cytoprotection; Hydrogen Sulfide; Lipopolysaccharides; Liver; Lung; Macrophages; Male; Mice; Morpholines; NF-kappa B; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Shock, Septic; STAT3 Transcription Factor

2009
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages.
    Antioxidants & redox signaling, 2010, May-15, Volume: 12, Issue:10

    Topics: Activating Transcription Factor 2; Air Pollutants; Animals; Cell Line; HSP27 Heat-Shock Proteins; Hydrogen Sulfide; Inflammation Mediators; Lipopolysaccharides; Macrophages; Mice; Morpholines; NF-kappa B; Organothiophosphorus Compounds; Sulfides

2010
[Effect of synthesized GYY4137, a slowly releasing hydrogen sulfide donor, on cell viability and distribution of hydrogen sulfide in mice].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2010, Oct-18, Volume: 42, Issue:5

    Topics: Animals; Cell Survival; Hep G2 Cells; Humans; Hydrogen Sulfide; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred ICR; Morpholines; Organothiophosphorus Compounds; Tissue Distribution

2010
A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation.
    Plant physiology and biochemistry : PPB, 2010, Volume: 48, Issue:12

    Topics: Arabidopsis; Darkness; Hydrogen Sulfide; Light; Morpholines; Nitric Oxide; Organothiophosphorus Compounds; Plant Stomata; Sulfhydryl Compounds

2010
Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:4

    Topics: Bronchi; Cell Proliferation; Cells, Cultured; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydrogen Sulfide; Interleukin-1beta; Interleukin-8; Methemoglobin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Myocytes, Smooth Muscle; Organothiophosphorus Compounds; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Serum; Sulfides

2011
The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; HCT116 Cells; Hep G2 Cells; HL-60 Cells; Humans; Hydrogen Sulfide; Mice; Mice, SCID; Morpholines; Organothiophosphorus Compounds; Xenograft Model Antitumor Assays

2011
Hydrogen sulfide effects on stomatal apertures.
    Plant signaling & behavior, 2011, Volume: 6, Issue:10

    Topics: Capsicum; Hydrogen Sulfide; Morpholines; Nitric Oxide; Organothiophosphorus Compounds; Plant Stomata; Sulfides

2011
Imaging the uptake of gold nanoshells in live cells using plasmon resonance enhanced four wave mixing microscopy.
    Optics express, 2011, Aug-29, Volume: 19, Issue:18

    Topics: Animals; Biological Transport, Active; Cell Line; Gold; Hydrogen Sulfide; Image Processing, Computer-Assisted; Mice; Microscopy; Morpholines; Nanoshells; Optical Phenomena; Organothiophosphorus Compounds; Single-Cell Analysis; Spectrum Analysis, Raman; Surface Plasmon Resonance

2011
Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes.
    Pharmacological research, 2012, Volume: 66, Issue:5

    Topics: Cell Line; Cell Proliferation; Cell Survival; Humans; Hydrogen Sulfide; Keratinocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitric Oxide; Nitric Oxide Synthase Type II; Organothiophosphorus Compounds; Proto-Oncogene Proteins c-akt; Sulfides; Vascular Endothelial Growth Factor A

2012
A new slow releasing, H₂S generating compound, GYY4137 relaxes spontaneous and oxytocin-stimulated contractions of human and rat pregnant myometrium.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adult; Animals; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Female; Glyburide; Humans; Hydrogen Sulfide; KATP Channels; Labor, Obstetric; Middle Aged; Morpholines; Myometrium; Obstetric Labor, Premature; Organothiophosphorus Compounds; Oxytocics; Oxytocin; Pregnancy; Rats; Sulfides; Tocolytic Agents; Uterine Contraction

2012
The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells.
    Journal of cellular and molecular medicine, 2013, Volume: 17, Issue:3

    Topics: Acute Disease; Animals; Arthritis; Cartilage; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Hydrogen Sulfide; Inflammation; Inflammation Mediators; Joints; Lipopolysaccharides; Mice; Morpholines; NF-kappa B; Nitric Oxide Synthase Type II; Organothiophosphorus Compounds; Synovial Membrane; Tumor Necrosis Factor-alpha

2013
Hydrogen sulfide mediated inhibitory neurotransmission to the pig bladder neck: role of KATP channels, sensory nerves and calcium signaling.
    The Journal of urology, 2013, Volume: 190, Issue:2

    Topics: Acetanilides; Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Calcium Signaling; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Glyburide; Guanylate Cyclase; Hydrogen Sulfide; Indomethacin; KATP Channels; Morpholines; Muscle, Smooth; Organothiophosphorus Compounds; Phenylephrine; Pituitary Adenylate Cyclase-Activating Polypeptide; Purines; Pyrazoles; Sensory Receptor Cells; Swine; Synaptic Transmission; Urinary Bladder

2013
Hydrogen sulphide may be a novel downstream signal molecule in nitric oxide-induced heat tolerance of maize (Zea mays L.) seedlings.
    Plant, cell & environment, 2013, Volume: 36, Issue:8

    Topics: Acclimatization; Hot Temperature; Hydrogen Sulfide; Morpholines; Nitric Oxide; Nitroprusside; Organothiophosphorus Compounds; Plant Leaves; Seedlings; Signal Transduction; Zea mays

2013
Investigation of hydrogen sulfide gas as a treatment against P. falciparum, murine cerebral malaria, and the importance of thiolation state in the development of cerebral malaria.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Blood Platelets; Dose-Response Relationship, Drug; Erythrocytes; Humans; Hydrogen Sulfide; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Morpholines; Organothiophosphorus Compounds; Plasmodium berghei; Plasmodium falciparum; Species Specificity; Sulfhydryl Compounds; Sulfides

2013
Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.
    Acta physiologica (Oxford, England), 2013, Volume: 208, Issue:4

    Topics: Apoptosis; Calcium Signaling; HeLa Cells; Humans; Hydrogen Sulfide; Inositol 1,4,5-Trisphosphate Receptors; Morpholines; Organothiophosphorus Compounds; Up-Regulation

2013
Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice.
    Platelets, 2014, Volume: 25, Issue:3

    Topics: Acid Phosphatase; Animals; Blood Platelets; Humans; Hydrogen Sulfide; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Morpholines; Organothiophosphorus Compounds; P-Selectin; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Tartrate-Resistant Acid Phosphatase; Thrombosis

2014
Polysulfides link H2S to protein thiol oxidation.
    Antioxidants & redox signaling, 2013, Nov-20, Volume: 19, Issue:15

    Topics: Catalytic Domain; Cell Line; Cysteine; Enzyme Activation; Humans; Hydrogen Sulfide; Kinetics; Morpholines; Organothiophosphorus Compounds; Oxidation-Reduction; Proteins; PTEN Phosphohydrolase; Solutions; Sulfhydryl Compounds; Sulfides

2013
Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia.
    Circulation, 2013, Jun-25, Volume: 127, Issue:25

    Topics: Adolescent; Adult; Alkynes; Animals; Antigens, CD; Cells, Cultured; Cystathionine gamma-Lyase; Disease Models, Animal; Endoglin; Endothelium, Vascular; Female; Fetal Development; Glycine; Humans; Hydrogen Sulfide; Hypertension; Mice; Mice, Inbred C57BL; Morpholines; Neovascularization, Physiologic; Organ Culture Techniques; Organothiophosphorus Compounds; Placenta; Placenta Diseases; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Proteins; Pregnancy, Animal; Receptors, Cell Surface; Vascular Endothelial Growth Factor Receptor-1; Young Adult

2013
Hydrogen sulfide inhibits abnormal proliferation of lymphocytes via AKT/GSK3β signal pathway in systemic lupus erythematosus patients.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 31, Issue:6

    Topics: Cell Proliferation; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hydrogen Sulfide; Lithium Chloride; Lupus Erythematosus, Systemic; Lymphocytes; Morpholines; Organothiophosphorus Compounds; Phosphorylation; Phytohemagglutinins; Proto-Oncogene Proteins c-akt; S Phase Cell Cycle Checkpoints; Signal Transduction

2013
Increase or decrease hydrogen sulfide exert opposite lipolysis, but reduce global insulin resistance in high fatty diet induced obese mice.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Adipocytes; Alkynes; Animals; Blood Glucose; Carrier Proteins; Cystathionine gamma-Lyase; Cysteine; Diet, High-Fat; Enzyme Inhibitors; Glycerol; Glycine; Hydrogen Sulfide; Insulin; Insulin Resistance; Isoproterenol; Lipolysis; Mice; Morpholines; Obesity; Organothiophosphorus Compounds; Perilipin-1; Phosphoproteins; Primary Cell Culture; Pyridoxal Phosphate; Rats; Sterol Esterase

2013
Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans.
    Antioxidants & redox signaling, 2014, Jun-01, Volume: 20, Issue:16

    Topics: Aging; Animals; Caenorhabditis elegans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Structure-Activity Relationship

2014
Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery.
    Experimental eye research, 2013, Volume: 116

    Topics: Animals; Cattle; Ciliary Arteries; Delayed-Action Preparations; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Phenylephrine; Vasoconstrictor Agents; Vasodilation

2013
C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Aging; Animals; Aorta; Caenorhabditis elegans; Cattle; Cell Death; Cell Survival; Cells, Cultured; Cysteine Synthase; Endoplasmic Reticulum; Endothelial Cells; Hydrogen Peroxide; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Reactive Oxygen Species

2013
GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK/mTOR signal pathway in H9c2 cells.
    Molecular and cellular biochemistry, 2014, Volume: 389, Issue:1-2

    Topics: AMP-Activated Protein Kinases; Animals; Cardiotonic Agents; Cell Line; Cell Survival; Cytoprotection; Glucose; Hydrogen Sulfide; Membrane Potential, Mitochondrial; Morpholines; Myocytes, Cardiac; Organothiophosphorus Compounds; Phosphorylation; Protective Agents; Rats; Signal Transduction; TOR Serine-Threonine Kinases

2014
Systemic hydrogen sulfide administration partially restores normal alveolarization in an experimental animal model of bronchopulmonary dysplasia.
    American journal of physiology. Lung cellular and molecular physiology, 2014, Apr-01, Volume: 306, Issue:7

    Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Cytokines; Disease Models, Animal; Hydrogen Sulfide; Hyperoxia; Lung; Mice; Morpholines; Organothiophosphorus Compounds; Oxygen; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli; Sulfides; Wound Healing

2014
Exogenous hydrogen sulfide (H2S) protects alveolar growth in experimental O2-induced neonatal lung injury.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Disease Models, Animal; Endothelial Cells; Humans; Hydrogen Sulfide; Hyperoxia; Infant, Newborn; Lung; Lung Injury; Mitochondria; Morpholines; Organothiophosphorus Compounds; Oxygen; Prodrugs; Protective Agents; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2014
H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channel.
    Biochemical and biophysical research communications, 2014, Mar-28, Volume: 446, Issue:1

    Topics: Bronchi; Bronchodilator Agents; Cells, Cultured; Cystathionine gamma-Lyase; Glyburide; Humans; Hydrogen Sulfide; KATP Channels; Morpholines; Muscle Relaxation; Myocytes, Smooth Muscle; Organothiophosphorus Compounds; Pinacidil; Sarcolemma; Sulfides

2014
CBS and CSE are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
    Antioxidants & redox signaling, 2014, Dec-01, Volume: 21, Issue:16

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Endotoxemia; Glucocorticoids; Hydrogen Sulfide; Lipopolysaccharides; Mice; Mitochondria; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; RNA, Small Interfering

2014
Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance.
    British journal of pharmacology, 2014, Volume: 171, Issue:18

    Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Survival; Glucose; Glycolysis; Humans; Hydrogen Sulfide; Hydrogen-Ion Concentration; Morpholines; Neoplasms; Organothiophosphorus Compounds; Sulfides

2014
Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes.
    Osteoarthritis and cartilage, 2014, Volume: 22, Issue:7

    Topics: Aged; Aged, 80 and over; Biomarkers; Cartilage, Articular; Cells, Cultured; Chondrocytes; Dinoprostone; Female; Humans; Hydrogen Sulfide; Inflammation; Interleukin-1beta; Interleukin-6; Male; Matrix Metalloproteinase 13; Metabolism; Morpholines; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Organothiophosphorus Compounds; Osteoarthritis; Sulfides

2014
GYY4137, a hydrogen sulfide‑releasing molecule, inhibits the inflammatory response by suppressing the activation of nuclear factor‑kappa B and mitogen‑activated protein kinases in Coxsackie virus B3‑infected rat cardiomyocytes.
    Molecular medicine reports, 2015, Volume: 11, Issue:3

    Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Cells, Cultured; Coxsackievirus Infections; DNA-Binding Proteins; Enterovirus B, Human; Enzyme Activation; Humans; Hydrogen Sulfide; Inflammation Mediators; Mitogen-Activated Protein Kinases; Morpholines; Myocarditis; Myocytes, Cardiac; NF-kappa B; Organothiophosphorus Compounds; Protein Transport; Proteolysis; Rats

2015
Hydrogen sulfide plays a key role in the inhibitory neurotransmission to the pig intravesical ureter.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Female; Hydrogen Sulfide; Male; Morpholines; Muscle, Smooth; Neuropeptides; Organothiophosphorus Compounds; Swine; Synaptic Transmission; Ureter; Vasoconstrictor Agents

2014
GYY4137 promotes bone formation in a rabbit distraction osteogenesis model: a preliminary report.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2015, Volume: 73, Issue:4

    Topics: Absorptiometry, Photon; Animals; Bone Density; Bone Regeneration; External Fixators; Hydrogen Sulfide; Injections, Intravenous; Male; Mandible; Morpholines; Organothiophosphorus Compounds; Osteogenesis; Osteogenesis, Distraction; Pliability; Rabbits; Random Allocation; Sodium Chloride; Spectrophotometry; Stress, Mechanical; Time Factors; Tomography, X-Ray Computed

2015
Role of hydrogen sulfide in paramyxovirus infections.
    Journal of virology, 2015, Volume: 89, Issue:10

    Topics: Alkynes; Cell Line; Chemokines; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Humans; Hydrogen Sulfide; Inflammation Mediators; Interferon Regulatory Factor-3; Morpholines; NF-kappa B; Organothiophosphorus Compounds; Paramyxoviridae Infections; Promoter Regions, Genetic; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Signal Transduction; Virus Replication

2015
Protein sulfhydration.
    Methods in enzymology, 2015, Volume: 555

    Topics: Biotin; Cell Line; Cysteine; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); Humans; Hydrogen Sulfide; Maleimides; Morpholines; Organothiophosphorus Compounds; Oxidation-Reduction; Phenanthrolines; Protein Processing, Post-Translational; Signal Transduction; Staining and Labeling; Streptavidin; Sulfides

2015
Hydrogen sulfide promotes adipogenesis in 3T3L1 cells.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Fatty Acid-Binding Proteins; Gene Expression; Glycerol; Hydrogen Sulfide; Lipid Metabolism; Lipolysis; Mice; Morpholines; Organothiophosphorus Compounds; RNA, Messenger; Sulfides; Sulfurtransferases

2015
Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: role of BK channels and cholinergic neurotransmission.
    American journal of physiology. Cell physiology, 2015, Jul-15, Volume: 309, Issue:2

    Topics: Acetylcholine; Animals; Calcium Channels, L-Type; Calcium Signaling; Cholinergic Fibers; Dose-Response Relationship, Drug; Guinea Pigs; Hydrogen Sulfide; In Vitro Techniques; Isometric Contraction; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Morpholines; Muscle, Smooth; Organothiophosphorus Compounds; Potassium; Potassium Channel Blockers; Synaptic Transmission; Time Factors; Urinary Bladder

2015
Hydrogen sulfide promotes calcium uptake in larval zebrafish.
    American journal of physiology. Cell physiology, 2015, Jul-01, Volume: 309, Issue:1

    Topics: Animals; Animals, Genetically Modified; Calcium; Cyclic AMP-Dependent Protein Kinases; Cystathionine beta-Synthase; Gene Knockdown Techniques; Hydrogen Sulfide; Ion Transport; Larva; Morpholines; Morpholinos; Oligonucleotides, Antisense; Organothiophosphorus Compounds; Protein Kinase Inhibitors; Sodium-Potassium-Exchanging ATPase; Sulfides; Time Factors; Zebrafish; Zebrafish Proteins

2015
8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis.
    Plant & cell physiology, 2015, Volume: 56, Issue:8

    Topics: Arabidopsis; Calcium; Cyclic GMP; Hydrogen Sulfide; Morpholines; Mutation; Nitric Oxide; Organothiophosphorus Compounds; Plant Leaves; Plant Stomata; Seedlings; Signal Transduction

2015
Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter.
    International journal of molecular sciences, 2015, Jun-03, Volume: 16, Issue:6

    Topics: Animals; Cells, Cultured; Cystathionine gamma-Lyase; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia; Inflammation Mediators; Macrophages; Male; Methionine; Mice; Morpholines; Organothiophosphorus Compounds; Promoter Regions, Genetic; Signal Transduction

2015
Exogenous Hydrogen Sulfide Attenuates Cardiac Fibrosis Through Reactive Oxygen Species Signal Pathways in Experimental Diabetes Mellitus Models.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 36, Issue:3

    Topics: Animals; Animals, Newborn; Diabetes Mellitus, Experimental; Fibroblasts; Gene Expression Regulation; Glucose; Hydrogen Sulfide; Hyperglycemia; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NADPH Oxidase 4; NADPH Oxidases; Organothiophosphorus Compounds; Primary Cell Culture; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Streptozocin; Sulfides

2015
GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia.
    Journal of molecular and cellular cardiology, 2015, Volume: 87

    Topics: Animals; Atrial Natriuretic Factor; Cardiotonic Agents; Humans; Hydrogen Sulfide; Ischemia; Morpholines; Myocardial Infarction; Natriuretic Peptide, Brain; Organothiophosphorus Compounds; Rats; Ventricular Dysfunction, Left; Ventricular Remodeling

2015
Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production.
    Science signaling, 2015, Dec-15, Volume: 8, Issue:407

    Topics: Adipose Tissue; Animals; Calcium Channels; Calcium Signaling; Cell Line; Cytokines; Hydrogen Sulfide; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Morpholines; Obesity; Organothiophosphorus Compounds

2015
Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro.
    Neurochemical research, 2016, Volume: 41, Issue:5

    Topics: Animals; Cattle; Ciliary Body; Cysteine; Electric Stimulation; Hydrogen Sulfide; In Vitro Techniques; Morpholines; Norepinephrine; Organothiophosphorus Compounds; Prostaglandins; Prostaglandins F, Synthetic; Sympathetic Nervous System; Synaptic Transmission; Thioctic Acid; Uvea

2016
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
    Journal of vascular surgery, 2017, Volume: 65, Issue:2

    Topics: Acute Lung Injury; Alkynes; Angiopoietin-2; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Constriction; Cystathionine gamma-Lyase; Cytoprotection; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Lung; Lyases; Male; Morpholines; Organothiophosphorus Compounds; Pneumonia; Proto-Oncogene Proteins c-akt; Rats, Wistar

2017
Hypoxic conditions increases H₂S-induced ER stress in A2870 cells.
    Molecular and cellular biochemistry, 2016, Volume: 414, Issue:1-2

    Topics: Amino Acids, Dicarboxylic; Cell Hypoxia; Cell Line, Tumor; Endoplasmic Reticulum Stress; Gene Expression; Humans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds

2016
Hydrogen sulfide depletion contributes to microvascular remodeling in obesity.
    American journal of physiology. Heart and circulatory physiology, 2016, 05-01, Volume: 310, Issue:9

    Topics: Alkynes; Animals; Arterioles; Cells, Cultured; Collagen; Collagenases; Cystathionine gamma-Lyase; Diet, High-Fat; Disease Models, Animal; Elastin; Enzyme Inhibitors; Fibronectins; Gene Expression Regulation; Glycine; Hydrogen Sulfide; Hypertrophy; Male; Mesentery; Mice, Inbred C57BL; Morpholines; Obesity; Organothiophosphorus Compounds; Signal Transduction; Vascular Remodeling; Vascular Stiffness

2016
Slow sulfide donor GYY4137 differentiates NG108-15 neuronal cells through different intracellular transporters than dbcAMP.
    Neuroscience, 2016, 06-14, Volume: 325

    Topics: Animals; Bucladesine; Calcium; Cell Differentiation; Cell Line, Tumor; Hydrogen Sulfide; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Inbred BALB C; Morpholines; Neurons; Organothiophosphorus Compounds; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases

2016
Cross talk between polysulfide and nitric oxide in rat peritoneal mast cells.
    American journal of physiology. Cell physiology, 2016, 06-01, Volume: 310, Issue:11

    Topics: Animals; Calcium Signaling; Enzyme Activation; Homeostasis; Hydrazines; Hydrogen Sulfide; Male; Mast Cells; Morpholines; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Organothiophosphorus Compounds; Peritoneum; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Sodium Compounds; Sulfides; Time Factors

2016
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy.
    The Journal of urology, 2016, Volume: 196, Issue:6

    Topics: Animals; Chronic Disease; Hydrogen Sulfide; Kidney Diseases; Male; Morpholines; Organothiophosphorus Compounds; Rats; Rats, Inbred Lew; Swine; Ureteral Obstruction

2016
Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.
    Diabetes, 2016, Volume: 65, Issue:10

    Topics: Active Transport, Cell Nucleus; Animals; Atherosclerosis; Diabetes Mellitus; Female; Glucose; Heme Oxygenase-1; Hydrogen Sulfide; Kelch-Like ECH-Associated Protein 1; Lipoproteins, LDL; Macrophages, Peritoneal; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; NF-E2-Related Factor 2; Organothiophosphorus Compounds; Protein Binding; Receptors, LDL

2016
A H 2 S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice.
    Mediators of inflammation, 2016, Volume: 2016

    Topics: Animals; Apoptosis; Cisplatin; Hydrogen Sulfide; Inflammation; Kidney; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Renal Insufficiency; Thiobarbituric Acid Reactive Substances

2016
Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137.
    Pharmacological research, 2016, Volume: 111

    Topics: Animals; Cytoprotection; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3 beta; Hemodynamics; Hydrogen Sulfide; Male; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Organothiophosphorus Compounds; Phosphatidylinositol 3-Kinase; Phosphorylation; Protective Agents; Rats, Sprague-Dawley; Signal Transduction; Time Factors

2016
Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice.
    International immunopharmacology, 2016, Volume: 39

    Topics: Animals; Caco-2 Cells; Cell Membrane Permeability; Colitis; Colon; Cystathionine beta-Synthase; Dextran Sulfate; Female; Humans; Hydrogen Sulfide; Mice; Mice, Inbred Strains; Morpholines; Organothiophosphorus Compounds; RNA, Small Interfering; Tight Junctions

2016
Hydrogen Sulfide Regulates Krüppel-Like Factor 5 Transcription Activity via Specificity Protein 1 S-Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy.
    Journal of the American Heart Association, 2016, 09-16, Volume: 5, Issue:9

    Topics: Angiotensin II; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Case-Control Studies; Cystathionine gamma-Lyase; Gene Expression Regulation; Humans; Hydrogen Sulfide; Kruppel-Like Transcription Factors; Male; Morpholines; Myocardium; Myocytes, Cardiac; Organothiophosphorus Compounds; Platelet-Derived Growth Factor; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; RNA, Messenger; Sp1 Transcription Factor; Transcriptional Activation

2016
The effects of hydrogen sulfide on platelet-leukocyte aggregation and microvascular thrombolysis.
    Platelets, 2017, Volume: 28, Issue:5

    Topics: Adult; Arterioles; Blood Platelets; Female; Humans; Hydrogen Sulfide; Leukocyte Common Antigens; Leukocytes; Male; Morpholines; Organothiophosphorus Compounds; P-Selectin; Platelet Aggregation; Tartrate-Resistant Acid Phosphatase; Thrombolytic Therapy; Venules

2017
Reduced Production of Hydrogen Sulfide and Sulfane Sulfur Due to Low Cystathionine β-Synthase Levels in Brain Astrocytes of Stroke-Prone Spontaneously Hypertensive Rats.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:12

    Topics: Animals; Astrocytes; Brain; Cell Survival; Cells, Cultured; Cystathionine beta-Synthase; Glucose Oxidase; Glutathione; Glutathione Disulfide; Hydrogen Peroxide; Hydrogen Sulfide; Hypertension; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Rats, Inbred SHR; Stroke; Sulfur

2016
H2S Attenuates LPS-Induced Acute Lung Injury by Reducing Oxidative/Nitrative Stress and Inflammation.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 40, Issue:6

    Topics: Acute Lung Injury; Animals; Antioxidants; Endotoxemia; Hydrogen Peroxide; Hydrogen Sulfide; Inflammation; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Malondialdehyde; Mice, Inbred ICR; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrosation; Organothiophosphorus Compounds; Oxidative Stress; Tyrosine

2016
Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses.
    Scientific reports, 2017, 01-20, Volume: 7

    Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Cell Line; Cytokines; Humans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; RNA Viruses; Virus Replication

2017
Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery Disease.
    Shock (Augusta, Ga.), 2017, Volume: 48, Issue:2

    Topics: Animals; Coronary Artery Disease; Delayed-Action Preparations; Disease Models, Animal; Heart; Hydrogen Sulfide; Kidney; Morpholines; Organothiophosphorus Compounds; Resuscitation; Shock, Septic; Swine

2017
Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide.
    Oncotarget, 2017, May-09, Volume: 8, Issue:19

    Topics: Animals; Aorta; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activation; Guanylate Cyclase; Hydrogen Sulfide; Male; Morpholines; Myocytes, Smooth Muscle; Organothiophosphorus Compounds; Protein Multimerization; Rats; Signal Transduction; Sulfides; Vasodilator Agents

2017
Parenteral Na
    Acta biochimica Polonica, 2017, Volume: 64, Issue:3

    Topics: Animals; Blood Pressure; Buffers; Drug Stability; Half-Life; Hydrogen Sulfide; Hydrogen-Ion Concentration; Infusions, Intravenous; Injections, Intraperitoneal; Male; Morpholines; Organothiophosphorus Compounds; Rats, Wistar; Sulfides

2017
GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney.
    Scientific reports, 2017, 09-07, Volume: 7, Issue:1

    Topics: Animals; Collagen; Diabetic Nephropathies; Disease Models, Animal; Endothelial Cells; Hydrogen Sulfide; Matrix Metalloproteinases; Mice; MicroRNAs; Morpholines; Organothiophosphorus Compounds; Poly (ADP-Ribose) Polymerase-1; Treatment Outcome

2017
Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice.
    Endocrinology, 2017, 10-01, Volume: 158, Issue:10

    Topics: Animals; Blotting, Western; Chondroitin Sulfates; Colon; Desulfovibrio; DNA, Bacterial; Eating; Feces; Gastrointestinal Microbiome; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hydrogen Sulfide; Insulin; Insulin Secretion; Intestinal Mucosa; Male; Mice; Morpholines; Organothiophosphorus Compounds; Prebiotics; Real-Time Polymerase Chain Reaction; Sulfides

2017
Hydrogen Sulfide Protects Retinal Ganglion Cells Against Glaucomatous Injury In Vitro and In Vivo.
    Investigative ophthalmology & visual science, 2017, 10-01, Volume: 58, Issue:12

    Topics: Animals; Disease Models, Animal; Female; Glaucoma; Hydrogen Peroxide; Hydrogen Sulfide; Hydrostatic Pressure; Intraocular Pressure; Morpholines; Nerve Crush; Neuroprotective Agents; Optic Nerve Injuries; Organothiophosphorus Compounds; Oxidative Stress; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells

2017
Exogenous hydrogen sulfide inhibits oral mucosal wound-induced macrophage activation via the NF-κB pathway.
    Oral diseases, 2018, Volume: 24, Issue:5

    Topics: Animals; Cell Line; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Female; Hydrogen Sulfide; Macrophage Activation; Macrophages, Peritoneal; Mice, Inbred C57BL; Morpholines; Mouth Mucosa; NF-kappa B; Nitric Oxide Synthase Type II; Organothiophosphorus Compounds; Signal Transduction; Wound Healing; Wounds and Injuries

2018
Endogenous H
    Molecular and cellular endocrinology, 2018, 10-15, Volume: 474

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Apoptosis; Corticosterone; Cystathionine beta-Synthase; Cysteine; Endotoxemia; Hydrogen Sulfide; Lipopolysaccharides; Male; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proton-Translocating ATPases; Morpholines; Organothiophosphorus Compounds; Sulfides

2018
Hydrogen sulfide donor, NaHS, stimulates ANP secretion via the K
    Peptides, 2019, Volume: 111

    Topics: Animals; Atrial Natriuretic Factor; Heart Atria; Hydrogen Sulfide; In Vitro Techniques; KATP Channels; Male; Morpholines; Nitric Oxide Synthase; Organothiophosphorus Compounds; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Soluble Guanylyl Cyclase; Sulfides; Thiosulfates

2019
Hydrogen sulphide facilitates exocytosis by regulating the handling of intracellular calcium by chromaffin cells.
    Pflugers Archiv : European journal of physiology, 2018, Volume: 470, Issue:8

    Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Cytosol; Endoplasmic Reticulum; Exocytosis; Hydrogen Sulfide; Mitochondria; Morpholines; Organothiophosphorus Compounds; Potassium

2018
Thiol-Activated Hydrogen Sulfide Donors Antiviral and Anti-Inflammatory Activity in Respiratory Syncytial Virus Infection.
    Viruses, 2018, 05-10, Volume: 10, Issue:5

    Topics: A549 Cells; Administration, Intranasal; Animals; Antiviral Agents; Cytokines; Disease Models, Animal; Female; Humans; Hydrogen Sulfide; Lung; Mice; Mice, Inbred BALB C; Morpholines; Organothiophosphorus Compounds; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Sulfhydryl Compounds; Virus Replication

2018
The effects of hydrogen sulfide on microvascular circulation in the axial pattern flap ear model in hairless mice.
    Microvascular research, 2018, Volume: 120

    Topics: Animals; Capillaries; Ear; Edema; Hydrogen Sulfide; Mice, Hairless; Microcirculation; Morpholines; Necrosis; Organothiophosphorus Compounds; Regional Blood Flow; Surgical Flaps; Tissue Survival

2018
Possible role of hydrogen sulfide as an endogenous relaxation factor in the rat bladder and prostate.
    Neurourology and urodynamics, 2018, Volume: 37, Issue:8

    Topics: Adrenergic beta-Antagonists; Animals; Carbachol; Hydrogen Sulfide; Male; Morpholines; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Organothiophosphorus Compounds; Parasympathomimetics; Propranolol; Prostate; Rats; Rats, Wistar; Sympathomimetics; Urinary Bladder; Urination

2018
Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex.
    Journal of the American Chemical Society, 2018, 10-03, Volume: 140, Issue:39

    Topics: A549 Cells; Cell Line; Coordination Complexes; Crystallography, X-Ray; Humans; Hydrogen Sulfide; Morpholines; Myocytes, Cardiac; Organothiophosphorus Compounds; Photochemical Processes; Prodrugs; Reperfusion Injury; Ruthenium

2018
Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia.
    The Journal of surgical research, 2019, Volume: 234

    Topics: Animals; Biomarkers; Cytokines; Drug Administration Schedule; Endothelium, Vascular; Enterocolitis, Necrotizing; Hydrogen Sulfide; Injections, Intraperitoneal; Intestinal Mucosa; Male; Mesenteric Ischemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Organothiophosphorus Compounds; Protective Agents; Reperfusion Injury; Treatment Outcome

2019
Improved growth of pea, lettuce, and radish plants using the slow release of hydrogen sulfide from GYY-4137.
    PloS one, 2018, Volume: 13, Issue:12

    Topics: Hydrogen Sulfide; Hydrolysis; Lactuca; Morpholines; Organothiophosphorus Compounds; Pisum sativum; Raphanus; Water

2018
Hydrogen sulfide attenuates lung ischemia-reperfusion injury through SIRT3-dependent regulation of mitochondrial function in type 2 diabetic rats.
    Surgery, 2019, Volume: 165, Issue:5

    Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Drug Evaluation, Preclinical; Humans; Hydrogen Sulfide; Lung; Lung Injury; Male; Mitochondria; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Rats; Reperfusion Injury; RNA, Small Interfering; Signal Transduction; Sirtuins; Streptozocin

2019
Sodium/calcium exchanger is involved in apoptosis induced by H
    Nitric oxide : biology and chemistry, 2019, 06-01, Volume: 87

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Hydrogen Sulfide; Hydrogen-Ion Concentration; Mice, Nude; Morpholines; Organothiophosphorus Compounds; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchanger 1

2019
Treatment with hydrogen sulfide donor attenuates bone loss induced by modeled microgravity.
    Canadian journal of physiology and pharmacology, 2019, Volume: 97, Issue:7

    Topics: 3T3 Cells; Animals; Bone Resorption; Cell Differentiation; Gene Expression Regulation; Hydrogen Sulfide; Interleukin-6; Male; Mice; Morpholines; Organothiophosphorus Compounds; Osteoblasts; Rats; Rats, Sprague-Dawley; Weightlessness Simulation

2019
TLR2 and TLR4 interact with sulfide system in the modulation of mouse colonic motility.
    Neurogastroenterology and motility, 2019, Volume: 31, Issue:9

    Topics: Animals; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hydrogen Sulfide; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Muscle Contraction; Organ Culture Techniques; Organothiophosphorus Compounds; Toll-Like Receptor 2; Toll-Like Receptor 4

2019
Hydrogen sulfide impacts on inflammation-induced adipocyte dysfunction.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 131

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Alkynes; Animals; Cell Differentiation; Gene Expression; Glycine; Hydrogen Sulfide; Inflammation; Mice; Morpholines; Organothiophosphorus Compounds; Sulfides

2019
Effects of fast versus slow-releasing hydrogen sulfide donors in hypertension in pregnancy and fetoplacental growth restriction.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:12

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Female; Fetal Growth Retardation; Fetus; Hydrogen Sulfide; Hypertension; Litter Size; Malondialdehyde; Morpholines; Organothiophosphorus Compounds; Placenta; Pregnancy; Rats, Wistar; Sulfides

2019
Characterization of Dialkyldithiophosphates as Slow Hydrogen Sulfide Releasing Chemicals and Their Effect on the Growth of Maize.
    Journal of agricultural and food chemistry, 2019, Oct-30, Volume: 67, Issue:43

    Topics: Delayed-Action Preparations; Drug Carriers; Drug Compounding; Hydrogen Sulfide; Hydrolysis; Morpholines; Organothiophosphates; Organothiophosphorus Compounds; Zea mays

2019
Autonomous Temporal Control of Hydrogen Sulfide Delivery.
    Analytical chemistry, 2019, 12-17, Volume: 91, Issue:24

    Topics: Animals; Cell Culture Techniques; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Printing, Three-Dimensional

2019
Exogenous hydrogen sulfide alleviates surgery-induced neuroinflammatory cognitive impairment in adult mice by inhibiting NO signaling.
    BMC anesthesiology, 2020, 01-09, Volume: 20, Issue:1

    Topics: Animals; Brain Chemistry; Cognitive Dysfunction; Encephalitis; Enzyme Inhibitors; Hippocampus; Hydrogen Sulfide; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Organothiophosphorus Compounds; Postoperative Complications; Signal Transduction

2020
The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice.
    Clinical hemorheology and microcirculation, 2020, Volume: 75, Issue:4

    Topics: Animals; Carotid Arteries; Carotid Artery, Common; Disease Models, Animal; Hydrogen Sulfide; Male; Mice; Morpholines; Neointima; Organothiophosphorus Compounds

2020
Protective effect of GYY4137, a water‑soluble hydrogen sulfide‑releasing molecule, on intestinal ischemia‑reperfusion.
    Molecular medicine reports, 2020, Volume: 21, Issue:3

    Topics: Animals; Apoptosis; Biomarkers; Disease Models, Animal; Gene Expression; Hydrogen Sulfide; Immunohistochemistry; Intestinal Mucosa; Intestines; Male; Malondialdehyde; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Protective Agents; Rats; Reperfusion Injury; Superoxide Dismutase

2020
H
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020, Volume: 69, Issue:5

    Topics: Anti-Inflammatory Agents; Cell Line; Cytokines; Humans; Hydrogen Sulfide; Inflammation; Lipopolysaccharides; Morpholines; Nitric Oxide; Organothiophosphorus Compounds; Reactive Oxygen Species; Signal Transduction; Sulfides; Transcriptome

2020
Hydrogen Sulfide Alleviates Liver Injury Through the S-Sulfhydrated-Kelch-Like ECH-Associated Protein 1/Nuclear Erythroid 2-Related Factor 2/Low-Density Lipoprotein Receptor-Related Protein 1 Pathway.
    Hepatology (Baltimore, Md.), 2021, Volume: 73, Issue:1

    Topics: Animals; Diet, High-Fat; Hepatocytes; Humans; Hydrogen Sulfide; Kelch-Like ECH-Associated Protein 1; Lipoproteins, LDL; Liver; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice; Mice, Inbred C57BL; Morpholines; NF-E2-Related Factor 2; Organothiophosphorus Compounds; Oxidative Stress; Signal Transduction; Streptozocin

2021
Divergent effect of fast- and slow-releasing H
    Scientific reports, 2020, 04-16, Volume: 10, Issue:1

    Topics: Animals; Antioxidants; Humans; Hydrogen Sulfide; Male; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Sperm Motility; Spermatozoa; Sulfides; Swine

2020
Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis.
    International journal of molecular sciences, 2020, Oct-08, Volume: 21, Issue:19

    Topics: Animals; Arthralgia; Cartilage, Articular; Cyclooxygenase 2; Disease Models, Animal; Female; Gene Expression Regulation; Hydrogen Sulfide; Injections, Intra-Articular; Matrix Metalloproteinase 13; Morpholines; Motor Activity; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Organothiophosphorus Compounds; Osteoarthritis; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Rotarod Performance Test; Signal Transduction; Treatment Outcome

2020
The antihypertension effect of hydrogen sulfide (H
    Life sciences, 2021, Feb-15, Volume: 267

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Sulfide; Hypertension; Male; Malondialdehyde; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Protective Agents; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Superoxide Dismutase; Vascular Endothelial Growth Factor A

2021
Hydrogen sulfide restores sevoflurane postconditioning mediated cardioprotection in diabetic rats: Role of SIRT1/Nrf2 signaling-modulated mitochondrial dysfunction and oxidative stress.
    Journal of cellular physiology, 2021, Volume: 236, Issue:7

    Topics: Animals; Cardiotonic Agents; Diabetes Mellitus, Experimental; Heme Oxygenase (Decyclizing); Hydrogen Sulfide; Mitochondria; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; NADPH Oxidase 2; NF-E2-Related Factor 2; Organothiophosphorus Compounds; Oxidative Stress; Peroxiredoxins; Rats; Sevoflurane; Signal Transduction; Sirtuin 1

2021
Hydrogen Sulfide: A Potential Therapeutic Target in the Development of Diabetic Retinopathy.
    Investigative ophthalmology & visual science, 2020, 12-01, Volume: 61, Issue:14

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Fluorescent Antibody Technique; Humans; Hydrogen Sulfide; Male; Matrix Metalloproteinase 9; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Reactive Oxygen Species; Retina; Retinal Vessels; Tomography, Optical Coherence

2020
Hydrogen sulfide exacerbated periodontal inflammation and induced autophagy in experimental periodontitis.
    International immunopharmacology, 2021, Volume: 93

    Topics: Animals; Anti-Inflammatory Agents; Autophagy; Beclin-1; Cells, Cultured; Humans; Hydrogen Sulfide; Inflammation; Lactosylceramides; Male; Models, Animal; Morpholines; Organothiophosphorus Compounds; Periodontitis; Rats; Rats, Sprague-Dawley

2021
Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78/mTOR pathway in rat chondrocytes subjected to oxidative stress.
    International journal of molecular medicine, 2021, Volume: 47, Issue:4

    Topics: Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Survival; Chloroquine; Chondrocytes; Cytoprotection; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Hydrogen Sulfide; Male; Morpholines; Organothiophosphorus Compounds; Oxidative Stress; Peroxides; Protective Agents; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases

2021
Hydrogen sulfide inhibits calcium and phosphorus loss after fracture by negatively regulating glucocorticoid/glucocorticoid receptor α.
    Life sciences, 2021, Jun-01, Volume: 274

    Topics: Animals; Calcium; Femoral Fractures; Gasotransmitters; Gene Expression Regulation; Hydrogen Sulfide; Male; Morpholines; Organothiophosphorus Compounds; Phosphorus; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid

2021
Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1.
    Scientific reports, 2021, 04-14, Volume: 11, Issue:1

    Topics: Action Potentials; Animals; Cells, Cultured; Down-Regulation; HEK293 Cells; Hippocampus; Humans; Hydrogen Sulfide; Morpholines; Neurons; Organothiophosphorus Compounds; Phosphorylation; Primary Cell Culture; Rats; Shab Potassium Channels

2021
GYY4137 protected the integrity of the blood-brain barrier via activation of the Nrf2/ARE pathway in mice with sepsis.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:7

    Topics: Animals; Apoptosis; Biological Transport; Blood-Brain Barrier; Brain; Disease Models, Animal; Hydrogen Sulfide; Kelch-Like ECH-Associated Protein 1; Male; Mice; Mice, Inbred C57BL; Morpholines; NF-E2-Related Factor 2; Organothiophosphorus Compounds; Oxidative Stress; Sepsis; Signal Transduction

2021
AMPK S-sulfuration contributes to H
    Neurochemistry international, 2021, Volume: 150

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cell Survival; Dopaminergic Neurons; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; PC12 Cells; Phosphorylation; Rats; Sulfides

2021
Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis.
    eLife, 2021, 11-18, Volume: 10

    Topics: Energy Metabolism; HIV; Homeostasis; Hydrogen Sulfide; Mitochondria; Morpholines; Organothiophosphorus Compounds; Oxidation-Reduction; Virus Latency; Virus Replication

2021
Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury.
    Molecular immunology, 2022, Volume: 141

    Topics: Acute Lung Injury; Animals; Autophagy; Cecum; Cell Line; Disease Models, Animal; Ferroptosis; Hydrogen Sulfide; Ligation; Lung; Male; Mice; Mice, Inbred C57BL; Morpholines; Multiple Organ Failure; Organothiophosphorus Compounds; RAW 264.7 Cells; Sepsis; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2022
Slow sulfide donor GYY4137 potentiates effect of paclitaxel on colorectal carcinoma cells.
    European journal of pharmacology, 2022, May-05, Volume: 922

    Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Humans; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Paclitaxel; Sulfides

2022
GYY4137 ameliorates sepsis-induced cardiomyopathy via NLRP3 pathway.
    Biochimica et biophysica acta. Molecular basis of disease, 2022, 12-01, Volume: 1868, Issue:12

    Topics: Animals; Cardiomyopathies; Cytokines; Hydrogen Sulfide; Inflammasomes; Lipopolysaccharides; Mice; Morpholines; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Organothiophosphorus Compounds; Reactive Oxygen Species; RNA; Sepsis

2022
Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H
    International journal of molecular sciences, 2022, Aug-16, Volume: 23, Issue:16

    Topics: Animals; Cystathionine gamma-Lyase; Fructose; Hydrogen Sulfide; Morpholines; Nitric Oxide; Organothiophosphorus Compounds; Rats; Rats, Inbred SHR; Sulfides; Tumor Necrosis Factor-alpha

2022
Excitatory Effects of Astrocytic Hydrogen Sulfide on the Electrical Activity of Oxytocin Neurons in the Supraoptic Nucleus.
    Neuroendocrinology, 2023, Volume: 113, Issue:3

    Topics: Animals; Astrocytes; Hydrogen Sulfide; Male; Neurons; Oxytocin; Rats; Supraoptic Nucleus

2023
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
    Experimental cell research, 2022, 11-01, Volume: 420, Issue:1

    Topics: Apoptosis; Autophagy; beta Catenin; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Glycogen Synthase Kinase 3 beta; Humans; Hyaluronic Acid; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Sulfides; Thiones; TOR Serine-Threonine Kinases

2022
Cystathionine γ-lyase and hydrogen sulfide modulates glucose transporter Glut1 expression via NF-κB and PI3k/Akt in macrophages during inflammation.
    PloS one, 2022, Volume: 17, Issue:12

    Topics: Cystathionine gamma-Lyase; Glucose Transport Proteins, Facilitative; Humans; Hydrogen Sulfide; Inflammation; Lipopolysaccharides; Macrophages; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Isoforms; Proto-Oncogene Proteins c-akt

2022
Hydrogen Sulfide Promotes Osteogenesis by Modulating Macrophage Polarization.
    International immunopharmacology, 2023, Volume: 115

    Topics: Hydrogen Sulfide; Macrophages; Morpholines; Osteogenesis

2023
Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes.
    Toxins, 2023, 03-04, Volume: 15, Issue:3

    Topics: Cysteine; Escherichia coli; Hydrogen Sulfide; Neutrophils; Phosphatidylinositol 3-Kinases

2023
Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance.
    Journal of physiology and biochemistry, 2023, Volume: 79, Issue:3

    Topics: Diabetes Mellitus, Type 2; Humans; Hydrogen Sulfide; Macrophages; Osteoarthritis; Phenotype

2023
GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid.
    Vascular pharmacology, 2023, Volume: 152

    Topics: Animals; Bradykinin; Coronary Vessels; Endothelium, Vascular; Hydrogen Peroxide; Hydrogen Sulfide; Hypochlorous Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxidase; Swine

2023
Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway.
    Acta biochimica et biophysica Sinica, 2023, Aug-16, Volume: 55, Issue:9

    Topics: Endothelial Cells; Humans; Hydrogen Sulfide; Inflammation; PPAR delta; Sodium-Glucose Transporter 2; STAT3 Transcription Factor

2023
Hydrogen Sulfide Improves Outcomes in a Murine Model of Necrotizing Enterocolitis via the Cys440 Residue on Endothelial Nitric Oxide Synthase.
    Journal of pediatric surgery, 2023, Volume: 58, Issue:12

    Topics: Animals; Disease Models, Animal; Enterocolitis, Necrotizing; Humans; Hydrogen Sulfide; Infant, Newborn; Infant, Newborn, Diseases; Lung Injury; Mice; Nitric Oxide; Nitric Oxide Synthase Type III

2023
Ageing-Related Alterations in Renal Epithelial Glucose Transport.
    International journal of molecular sciences, 2023, Nov-17, Volume: 24, Issue:22

    Topics: Aging; Animals; Blood Glucose; Glucose; Hydrogen Sulfide; Kidney; Male; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley

2023