hydrochlorothiazide and trandolapril

hydrochlorothiazide has been researched along with trandolapril in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (17.24)18.2507
2000's16 (55.17)29.6817
2010's7 (24.14)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Andricopulo, AD; Moda, TL; Montanari, CA1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Pauly, NC; Safar, ME1
Meyer, BH; Pauly, NC1
de Leeuw, PW; Notter, T; Zilles, P1
Novrit, BA; Punzi, HA1
Belz, GG; Breithaupt-Grögler, K; Gerhardt, G; Lehmann, G; Notter, T1
Cifková, R; Compagnone, D; Hejl, Z; Nakov, R; Novozámská, E; Petrzílková, Z; Poledne, R; Stávek, P1
Fernández, R; Garrido, J; Puig, JG; Redon, J; Rodríguez-Pérez, JC1
Armenteros, S; Fernández González, R; Garrido, J; Goicolea, I; Martínez, JM; Moreno Carretero, E; Piniés, J1
Bakris, GL; Bristol, HA; Cangiano, JL; Cohen, JD; Cooper-DeHoff, RM; Erdine, S; Garcia-Barreto, D; Handberg, EM; Keltai, M; Kolb, HR; Kowey, P; Mancia, G; Marks, RG; Messerli, FH; Parmley, WW; Pepine, CJ1
Flack, JM1
Diethelm, M; Joerger, M1
Cooper-DeHoff, R; Elliott, WJ; Hewkin, AC; Kupfer, S; Pepine, CJ1
Bakris, GL; Cohen, JD; Cooper-Dehoff, R; Erdine, S; Hewkin, AC; Kupfer, S; Messerli, FH; Pepine, CJ1
Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T1
Cangiano, JL; Cooper-DeHoff, RM; Garcia-Barreto, D; Gaxiola, E; Handberg, E; Pepine, CJ; Zhou, Q1
Benetos, A; Champion, A; Coca, A; Cooper-DeHoff, RM; Messerli, FH; Pepine, CJ; Zhou, Q1
Bacher, P; Bakris, G; Champion, A; Molitch, M; Sarafidis, P; Sowers, JR; Zhou, Q1
Bakris, GL; Champion, A; Cooper-Dehoff, RM; Kupfer, S; Pepine, CJ; Zhou, Q1
Champion, A; Cooper-DeHoff, RM; Handberg, EM; Legler, UF; Mancia, G; Pepine, CJ; Zhou, Q1
Cervenka, L; Chábová, VČ; Husková, Z; Kompanowska-Jezierska, E; Kopkan, L; Kramer, HJ; Kujal, P; Malý, J; Netuka, I; Opočenský, M; Rakušan, D; Sadowski, J; Schejbalová, S; Skaroupková, P; Vaněčková, I; Vaňourková, Z; Vernerová, Z; Walkowska, A1
Brumback, BA; Cooper-Dehoff, RM; Delaney, JA; Gerhard, T; Johnson, JA; Pepine, CJ; Shuster, J; Winterstein, AG1
Bailey, KR; Beitelshees, AL; Boerwinkle, E; Chapman, AB; Cooper-DeHoff, RM; Gong, Y; Gums, JG; Johnson, JA; Kubo, M; Magvanjav, O; McDonough, CW; Pepine, CJ; Tanaka, T; Turner, ST1
Cooper-DeHoff, RM; Dasa, O; Gong, Y; Handberg, E; Howard, G; Pepine, CJ; Smith, SM1

Reviews

1 review(s) available for hydrochlorothiazide and trandolapril

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

16 trial(s) available for hydrochlorothiazide and trandolapril

ArticleYear
Comparison of the efficacy and safety of trandolapril and captopril for 16 weeks in mild-to-moderate essential hypertension. Investigator Study Group.
    Journal of cardiovascular pharmacology, 1994, Volume: 23 Suppl 4

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Captopril; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Middle Aged; Time Factors

1994
Double-blind comparison of the efficacy and safety of trandolapril 2 mg and hydrochlorothiazide 25 mg in patients with mild-to-moderate essential hypertension. Investigator Study Group.
    Journal of cardiovascular pharmacology, 1994, Volume: 23 Suppl 4

    Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Middle Aged

1994
Comparison of different fixed antihypertensive combination drugs: a double-blind, placebo-controlled parallel group study.
    Journal of hypertension, 1997, Volume: 15, Issue:1

    Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Drug Tolerance; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Lisinopril; Male; Middle Aged; Safety; Verapamil

1997
The treatment of severe hypertension with trandolapril, verapamil, and hydrochlorothiazide. Trandolapril/Verapamil Multicenter Study Group.
    Journal of human hypertension, 1997, Volume: 11, Issue:8

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Diuretics; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Middle Aged; Safety; Single-Blind Method; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Verapamil

1997
Blood pressure and aortic elastic properties--verapamil SR/trandolapril compared to a metoprolol/hydrochlorothiazide combination therapy.
    International journal of clinical pharmacology and therapeutics, 1998, Volume: 36, Issue:8

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aorta; Blood Pressure; Bradycardia; Calcium Channel Blockers; Cough; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Metoprolol; Middle Aged; Sodium Chloride Symporter Inhibitors; Verapamil

1998
Evaluation of the effects of fixed combinations of sustained-release verapamil/trandolapril versus captopril/hydrochlorothiazide on metabolic and electrolyte parameters in patients with essential hypertension.
    Journal of human hypertension, 2000, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Confidence Intervals; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Electrolytes; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Lipoproteins; Male; Middle Aged; Treatment Outcome; Vasodilator Agents; Verapamil

2000
Effect of two antihypertensive combinations on metabolic control in type-2 diabetic hypertensive patients with albuminuria: a randomised, double-blind study.
    Journal of human hypertension, 2001, Volume: 15, Issue:12

    Topics: Aged; Albuminuria; Analysis of Variance; Antihypertensive Agents; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Middle Aged; Multivariate Analysis; Probability; Prospective Studies; Spain; Treatment Outcome; Verapamil

2001
[Effect of antihypertensive combinations on arterial pressure, albuminuria, and glycemic control in patients with type II diabetic nephropathy: a randomized study].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2002, Volume: 22, Issue:2

    Topics: Aged; Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; Blood Pressure; Carbohydrate Metabolism; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hydrochlorothiazide; Hypertension; Indoles; Lipids; Losartan; Male; Middle Aged; Prospective Studies; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Vasodilator Agents; Verapamil

2002
A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial.
    JAMA, 2003, Dec-03, Volume: 290, Issue:21

    Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Blood Pressure; Calcium Channel Blockers; Coronary Artery Disease; Diuretics; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Verapamil

2003
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
    The American journal of cardiology, 2006, Oct-01, Volume: 98, Issue:7

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Channel Blockers; Coronary Artery Disease; Diabetes Mellitus; Drug Therapy, Combination; Female; Follow-Up Studies; Hispanic or Latino; Humans; Hydrochlorothiazide; Hypercholesterolemia; Hypertrophy, Left Ventricular; Indoles; Ischemic Attack, Transient; Male; Myocardial Revascularization; Residence Characteristics; Risk Factors; Stroke; Systole; Verapamil

2006
Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study.
    Circulation, 2007, Apr-17, Volume: 115, Issue:15

    Topics: Adult; Aged; Antihypertensive Agents; Appetite Depressants; Blood Pressure; Body Weight; Cyclobutanes; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Felodipine; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Metoprolol; Middle Aged; Obesity; Prospective Studies; Ramipril; Treatment Outcome; Verapamil

2007
Influence of Hispanic ethnicity on blood pressure control and cardiovascular outcomes in women with CAD and hypertension: findings from INVEST.
    Journal of women's health (2002), 2007, Volume: 16, Issue:5

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Confidence Intervals; Coronary Artery Disease; Female; Follow-Up Studies; Hispanic or Latino; Humans; Hydrochlorothiazide; Hypertension; Indoles; Middle Aged; Odds Ratio; Proportional Hazards Models; Treatment Outcome; White People; Women's Health

2007
Reversal of diuretic-associated impaired glucose tolerance and new-onset diabetes: results of the STAR-LET study.
    Journal of the cardiometabolic syndrome, 2008,Winter, Volume: 3, Issue:1

    Topics: Analysis of Variance; Chi-Square Distribution; Diabetes Mellitus; Diuretics; Female; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Hypertension; Indoles; Insulin Resistance; Losartan; Male; Metabolic Syndrome; Middle Aged; Renin-Angiotensin System; Verapamil

2008
Dual therapy in hypertensive patients with coronary artery disease: the role of calcium channel blockers and beta-blockers.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2007, Volume: 7 Suppl 1

    Topics: Adrenergic beta-Antagonists; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Blood Pressure; Calcium Channel Blockers; Coronary Artery Disease; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Treatment Outcome; Verapamil

2007
Comparing marginal structural models to standard methods for estimating treatment effects of antihypertensive combination therapy.
    BMC medical research methodology, 2012, Aug-06, Volume: 12

    Topics: Aged; Antihypertensive Agents; Blood Pressure; Confounding Factors, Epidemiologic; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Middle Aged; Models, Structural; Proportional Hazards Models; Risk Factors; Treatment Outcome; Verapamil

2012
Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.
    Journal of the American Heart Association, 2017, Nov-02, Volume: 6, Issue:11

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aldehyde Dehydrogenase 1 Family; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Blood Pressure; Calcium Channel Blockers; Chi-Square Distribution; Drug Combinations; Drug Resistance; Female; Florida; Genome-Wide Association Study; Georgia; Humans; Hydrochlorothiazide; Hypertension; Indoles; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pharmacogenetics; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Prospective Studies; Retinal Dehydrogenase; Risk Factors; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Vasodilator Agents; Verapamil; Young Adult

2017

Other Studies

12 other study(ies) available for hydrochlorothiazide and trandolapril

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Calcium antagonist strategies for coronary artery disease.
    Current hypertension reports, 2004, Volume: 6, Issue:3

    Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Coronary Artery Disease; Diastole; Humans; Hydrochlorothiazide; Indoles; Randomized Controlled Trials as Topic; Systole; Verapamil

2004
[Lethal polypharmacy in a patient with arterial hypertension].
    Deutsche medizinische Wochenschrift (1946), 2004, Dec-10, Volume: 129, Issue:50

    Topics: Aged; Aged, 80 and over; Amiloride; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Infarction; Diuretics; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Hypotension; Indoles; Male; Polypharmacy; Sodium Chloride Symporter Inhibitors; Timolol; Tomography, X-Ray Computed; Verapamil

2004
A drug dose model for predicting clinical outcomes in hypertensive coronary disease patients.
    Journal of clinical hypertension (Greenwich, Conn.), 2005, Volume: 7, Issue:11

    Topics: Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Chi-Square Distribution; Coronary Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Predictive Value of Tests; Proportional Hazards Models; Randomized Controlled Trials as Topic; Treatment Outcome; Verapamil

2005
Predicting stroke risk in hypertensive patients with coronary artery disease: a report from the INVEST.
    Stroke, 2008, Volume: 39, Issue:2

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Black People; Coronary Artery Disease; Databases, Factual; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Risk Factors; Stroke; United States; Verapamil

2008
INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study.
    Expert review of cardiovascular therapy, 2009, Volume: 7, Issue:11

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Coronary Artery Disease; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Diuretics; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Randomized Controlled Trials as Topic; Verapamil

2009
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:12

    Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Creatinine; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Furosemide; Hydrochlorothiazide; Hypertension; Indoles; Kidney Failure, Chronic; Labetalol; Losartan; Proteinuria; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System

2010
Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease: A Post Hoc Analysis of a Randomized Clinical Trial.
    JAMA network open, 2021, 04-01, Volume: 4, Issue:4

    Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Coronary Artery Disease; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Kaplan-Meier Estimate; Male; Middle Aged; Mortality; Proportional Hazards Models; Randomized Controlled Trials as Topic; Sex Factors; Verapamil

2021