hydrochlorothiazide has been researched along with timolol in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (73.42) | 18.7374 |
| 1990's | 2 (2.53) | 18.2507 |
| 2000's | 11 (13.92) | 29.6817 |
| 2010's | 7 (8.86) | 24.3611 |
| 2020's | 1 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Drayer, JI; Laragh, JH; Weber, MA | 1 |
| Mikkelsen, E; Pedersen, OL | 3 |
| Goldet, L; Jouve, A; Mathieu, M | 1 |
| Lederballe Pedersen, O | 1 |
| Glitz, T; Lion, MF; Moscovici, H; Occhialini, RP; Pinheiro, JP; Shiguematsu, S | 1 |
| Castenfors, H | 1 |
| Alimadadian, H; Aronow, WS; Burwell, D; Greenfield, R; Mann, W; Van Herick, R | 1 |
| Overlack, A; Stumpe, KO | 1 |
| Bobik, A; Jennings, G; Korner, P | 1 |
| Bergis, K | 1 |
| Gillies, A; Morgan, G; Morgan, T; Wilson, M | 1 |
| Laplante, L | 1 |
| Chappin, JJ; Henquet, JW; Hintzen, AH; Slagboom, G | 1 |
| Brailovsky, D | 1 |
| Bune, AJ; Chalmers, JP; England, JD; Fletcher, PJ; Horvath, JS; Korner, PI; Tiller, DJ | 1 |
| Agabiti-Rosei, E; Alicandri, C; Ambrosioni, E; Magnani, B; Miele, N; Muiesan, G | 1 |
| Habte, B | 1 |
| Jounela, AJ; Lumme, JA | 1 |
| Freeman, D; Lamki, L; McDonald, JW; Spence, JD; Wong, DG | 1 |
| Benfield, GF; Haffner, C; Harris, P; Stableforth, DE | 1 |
| Franklin, SS; Smith, RD | 2 |
| Akbar, FA; Cranfield, FR; Markanday, S; Shelton, JR; Walters, EG | 1 |
| Spence, JD; Wong, DG | 1 |
| Bannon, JA; Delisser, O; Schrogie, JJ; Stewart, KA | 1 |
| Schiffl, H; Schollmeyer, P | 1 |
| Brunner, HR; Graf, HJ; Jaussi, A; Porchet, M; Rion, F; Waeber, B | 1 |
| Franz, IW | 1 |
| Holzgreve, H; Middeke, M | 1 |
| Hunninghake, DB; Leon, AS | 1 |
| Steiness, E | 1 |
| Lehtonen, A; Lindroos, M | 1 |
| Currie, WJ; Isitt, VL; VandenBurg, MJ; Young, JH | 1 |
| Arr, SM; Wight, L; Woollard, ML; Young, JH | 1 |
| Obel, AO | 1 |
| Cooper, WD; Currie, WJ; Vandenburg, MJ | 3 |
| Arr, S; Parry, EE; Young, J | 1 |
| Knauf, H; Steim, H | 1 |
| Gould, BA; Hornung, RS; Kieso, H; Raftery, EB | 2 |
| Arr, S; Parry, EE; Tait, D | 1 |
| Brown, JL; Chrysant, SG; Hagstrom, D | 1 |
| Hagelund, CH; Tretli, S | 1 |
| Burns, DG; Pittaway, D | 1 |
| Pittaway, D | 1 |
| Andersson, PO; Henning, R; Karlberg, BE; Lins, LE; Nilsson, OR; Odar-Cederlöf, I; Tolagen, K | 1 |
| Jalonen, K; Pörsti, P; Ryysy, L; Toivonen, T; Viherkoski, M | 1 |
| Schwartz, FN; Tiffany, J | 1 |
| Ballo, M; Cospite, M; Ferrara, F; Lo Presti, T; Meli, F; Milio, G; Raimondi, F | 1 |
| Grimshaw, JJ; Jaffé, G; Vallé-Jones, JC; Warnock, JM | 1 |
| Cubberley, RB; Durley, Y; Thomas, S | 1 |
| Borba, P; Didier, M; França, P; Santos, A; Tenório, J | 1 |
| Enenkel, W; Nobis, H; Pollak, H; Prachar, H | 1 |
| Albanesi Filho, FM; Brandão, AP; Oigman, W | 1 |
| Pedersen, TR | 1 |
| Anderson, GM; Clark, JP; Gurwitz, JH; Lau, P; Rochon, PA; Shear, NH; Tu, JV | 1 |
| Castellano, PM; Ferraro, MC; Kaufman, TS | 1 |
| Diethelm, M; Joerger, M | 1 |
| Lataifeh, A; Mohammed, MS; Wedian, F | 1 |
1 review(s) available for hydrochlorothiazide and timolol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
40 trial(s) available for hydrochlorothiazide and timolol
| Article | Year |
|---|---|
Beta-blockers and uric-acid excretion.
Topics: Amiloride; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Timolol; Uric Acid | 1978 |
Results of a national therapeutic trial conducted in 10,000 hypertensive patients by 2000 general practitioners.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Drug Tolerance; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Timolol | 1978 |
[Treatment of mild to moderate essential arterial hypertension with timolol alone and in combination with hydrochlorothiazide + amiloride. A multicenter, double-blind, cross-over study].
Topics: Amiloride; Clinical Trials as Topic; Creatinine; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Placebos; Potassium; Propanolamines; Pyrazines; Timolol | 1977 |
[Double-blind study of the treatment of essential arterial hypertension with timolol and hydrochlorothiazide separately or in combination].
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Electrocardiography; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Timolol | 1977 |
Long term effect of timolol and hydrochlorothiazide, or hydrochlorothiazide and amiloride, in essential hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Propanolamines; Pulse; Pyrazines; Time Factors; Timolol | 1977 |
Effect of timolol plus hydrochlorothiazide plus hydralazine on essential hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Heart Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Placebos; Propanolamines; Timolol | 1978 |
[Antihypertensive effect of a fixed beta-receptor blockader-diuretic combination during a single daily administration].
Topics: Adult; Amiloride; Clinical Trials as Topic; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Placebos; Propanolamines; Pyrazines; Timolol | 1978 |
Serum potassium and uric acid changes during treatment with timolol alone and in combination with a diuretic.
Topics: Amiloride; Clinical Trials as Topic; Creatinine; Diuretics; Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Placebos; Potassium; Propanolamines; Sodium Chloride Symporter Inhibitors; Timolol; Uric Acid | 1979 |
Comparison of effectiveness of timolol administered once a day and twice a day in the control of blood pressure in essential hypertension.
Topics: Adult; Ambulatory Care; Amiloride; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Placebos; Posture; Propanolamines; Time Factors; Timolol | 1979 |
Individual factors influencing the response to a beta-adrenergic blocking agent given alone and in combination with a diuretic on arterial hypertension.
Topics: Adult; Aging; Amiloride; Body Weight; Clinical Trials as Topic; Drug Therapy, Combination; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Time Factors; Timolol | 1979 |
A simplified approach to the treatment of hypertension.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Placebos; Potassium; Propanolamines; Renin; Timolol | 1977 |
The use of timolol maleate alone and with diuretic in the treatment of essential hypertension.
Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Placebos; Potassium; Propanolamines; Pyrazines; Timolol | 1976 |
Quantitative effects of timolol and hydrochlorothiazide on blood pressure, heart rate and plasma renin activity: results of a double-blind factorial trial in patients with essential hypertension.
Topics: Adult; Antihypertensive Agents; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Renin; Timolol | 1976 |
Evaluation of the effect of timolol alone and in combination with hydrochlorothiazide and amiloride in the treatment of mild to moderate arterial hypertension: a double-blind, controlled study.
Topics: Adult; Amiloride; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1976 |
The efficacy of hydrochlorothiazide, timolol and enalapril in Ethiopians with essential hypertension.
Topics: Adult; Double-Blind Method; Drug Therapy, Combination; Enalapril; Ethiopia; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Timolol | 1992 |
Combined action of enalapril or timolol with hydrochlorothiazide plus amiloride in hypertension.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Clinical Trials as Topic; Drug Therapy, Combination; Enalapril; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Magnesium; Male; Middle Aged; Potassium; Timolol | 1987 |
Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics.
Topics: 6-Ketoprostaglandin F1 alpha; Adrenergic beta-Antagonists; Adult; Amiloride; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indenes; Male; Middle Aged; Naproxen; Piroxicam; Random Allocation; Sulindac; Thiazines; Thromboxane A2; Timolol | 1986 |
Comparison of effects of enalapril plus hydrochlorothiazide versus standard triple therapy on renal function in renovascular hypertension.
Topics: Adult; Aged; Blood Pressure; Enalapril; Female; Glomerular Filtration Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension, Renovascular; Kidney; Male; Middle Aged; Renal Circulation; Timolol | 1985 |
A comparison of enalapril plus hydrochlorothiazide with standard triple therapy in renovascular hypertension.
Topics: Adult; Aged; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Heart Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension, Renovascular; Kidney; Male; Middle Aged; Patient Dropouts; Prospective Studies; Random Allocation; Timolol | 1986 |
A comparative study of Spiroprop and Moducren in the treatment of mild to moderate hypertension in general practice.
Topics: Adolescent; Amiloride; Antihypertensive Agents; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Propranolol; Spironolactone; Timolol | 1988 |
Amiloride with or without salbutamol versus placebo: effects on lipoproteins in hypertensive patients treated with timolol-hydrochlorothiazide.
Topics: Albuterol; Amiloride; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Lipoproteins; Timolol | 1986 |
Metabolic consequences of long-term thiazide-based antihypertensive treatment of renal hypertension.
Topics: Adolescent; Adult; Aged; Amiloride; Blood Glucose; Blood Pressure; Cholesterol; Coronary Disease; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension, Renal; Lipids; Male; Middle Aged; Timolol; Triglycerides | 1985 |
[Usefulness of ambulatory registration of arterial pressure in therapeutic trials of antihypertensive agents].
Topics: Adult; Aged; Ambulatory Care; Amiloride; Antihypertensive Agents; Blood Pressure Determination; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Male; Methyldopa; Middle Aged; Private Practice; Timolol | 1985 |
[Potassium metabolism during antihypertensive treatment with beta-receptor blocker and diuretic treatment].
Topics: Adrenergic beta-Antagonists; Amiloride; Clopamide; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypokalemia; Natriuresis; Pindolol; Potassium; Timolol | 1981 |
A multiclinic double-blind comparison of timolol and hydrochlorothiazide alone and in combination in th e treatment of essential hypertension.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Time Factors; Timolol | 1983 |
Timolol and a hydrochlorothiazide-amiloride combination in the treatment of essential hypertension in young and middle-aged patients: a comparative study with once-daily administration.
Topics: Adult; Amiloride; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Random Allocation; Timolol | 1984 |
Comparison of a fixed ratio combination of hydrochlorothiazide, amiloride and timolol ('Moducren') given once versus twice daily in mild to moderate hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Drug Administration Schedule; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Time Factors; Timolol | 1984 |
Efficacy and tolerance of a fixed ratio combination of hydrochlorothiazide, amiloride and timolol, taken before or after food, in the treatment of hypertension.
Topics: Adult; Aged; Amiloride; Drug Combinations; Female; Food; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Timolol | 1984 |
A comparison of timolol plus hydrochlorothiazide plus amiloride and methyldopa in essential hypertension in Black Africans.
Topics: Adult; Amiloride; Antihypertensive Agents; Black People; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Kenya; Male; Methyldopa; Middle Aged; Pyrazines; Random Allocation; Timolol | 1983 |
Comparison of timolol/hydrochlorothiazide/amiloride ('Moducren') with cyclopenthiazide/potassium in mild to moderate hypertension.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Cyclopenthiazide; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Timolol | 1982 |
A general practice study of timolol/hydrochlorothiazide/amiloride ('Moducren'), a new therapy for hypertension, and the doctor's influence on management.
Topics: Adult; Aged; Amiloride; Blood Pressure; Drug Combinations; Family Practice; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Patient Compliance; Propanolamines; Pyrazines; Timolol | 1983 |
The influence of physicians' instructions on the outcome of antihypertensive therapy.
Topics: Adult; Aged; Amiloride; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Outcome and Process Assessment, Health Care; Patient Compliance; Physician-Patient Relations; Timolol | 1983 |
[Clinical trials with hypertensive patients in general practice].
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Random Allocation; Timolol | 1980 |
Combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A multicentre trial.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Maleates; Middle Aged; Placebos; Potassium; Propanolamines; Pyrazines; Timolol; Urate Oxidase | 1980 |
Evaluation of a fixed combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A long-term multicentre trial.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Diastole; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Patient Compliance; Potassium; Propanolamines; Pulse; Pyrazines; Systole; Time Factors; Timolol; Uric Acid | 1980 |
Timolol and hydrochlorothiazide-amiloride in primary hypertension.
Topics: Adult; Amiloride; Blood Pressure; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Renin; Timolol | 1980 |
Antihypertensive action of drug combination: Timolol, hydralazine, hydrochlorothiazide and triamterene.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Random Allocation; Timolol; Triamterene | 1981 |
Timolol maleate and hydrochlorothiazide in control of essential hypertension: use of a fixed combination for once-a-day administration.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Timolol | 1981 |
Antihypertensive effect of oral timolol maleate and hydrochlorothiazide once daily compared with hydrochlorothiazide once daily.
Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Timolol | 1981 |
[Hypertension treated with hydrochlorothiazide/amilorid and timolol maleate].
Topics: Adult; Amiloride; Blood Pressure; Double-Blind Method; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Propanolamines; Pyrazines; Timolol | 1980 |
38 other study(ies) available for hydrochlorothiazide and timolol
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Beta-blockade, renin and blood-pressure.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Drug Synergism; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Renin; Timolol | 1977 |
[Results of a field study with Moducrin in 12596 hypertensive patients].
Topics: Amiloride; Drug Combinations; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1979 |
[Comparison of timolol, hydrochlorothiazide and timolol-hydrochlorothiazide combination: study in 21 patients with mild to moderate essential arterial hypertension].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Timolol | 1978 |
Concomitant administration of timolol and hydrochlorothiazide/amiloride in hypertensive patients. Results of a titration study.
Topics: Adult; Aged; Amiloride; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1978 |
Dilutional hyponatraemia masquerading as subarachnoid haemorrhage in patient on hydrochlorothiazide/amiloride/timolol combined drug.
Topics: Amiloride; Diagnosis, Differential; Drug Combinations; Drug Interactions; Female; Humans; Hydrochlorothiazide; Hypertension; Hyponatremia; Middle Aged; Subarachnoid Hemorrhage; Timolol | 1986 |
Postmarketing study of timolol-hydrochlorothiazide antihypertensive therapy.
Topics: Adolescent; Adult; Aged; Dizziness; Drug Combinations; Fatigue; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nausea; Timolol | 1985 |
[The antihypertensive effect of a fixed combination of beta receptor blockaders and diuretics on the resting and exertion blood pressure of patients with essential hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Amiloride; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Physical Exertion; Rest; Timolol | 1980 |
Thiazide-induced potassium loss not prevented by beta blockade.
Topics: Aldosterone; Amiloride; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Kidney; Male; Potassium; Renin; Timolol | 1984 |
Do elderly patients respond differently to treatment with Moducren?
Topics: Adult; Age Factors; Aged; Amiloride; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Timolol | 1984 |
The use of a single combination tablet containing a beta blocker and a diuretic in patients uncontrolled on either alone.
Topics: Amiloride; Antihypertensive Agents; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Timolol | 1984 |
[Reliable lowering of blood pressure with one tablet of Moducrin daily (author's transl)].
Topics: Amiloride; Blood Pressure; Circadian Rhythm; Drug Combinations; Drug Evaluation; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Timolol | 1980 |
[Therapy of hypertension with timolol, hydrochlorothiazide and amiloride].
Topics: Amiloride; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Timolol | 1983 |
Antihypertensive and metabolic effects of hydrochlorothiazide, amiloride-hydrochlorothiazide, and timolol.
Topics: Amiloride; Antihypertensive Agents; Blood Pressure; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Timolol | 1983 |
[Antihypertensive effects of timolol and of the combination timolol, amiloride and hydrochlorothiazide].
Topics: Adult; Amiloride; Blood Pressure; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Renin; Sodium; Timolol | 1981 |
A comparative study of Moducren and Moduretic and their effect on plasma potassium in essential hypertension.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Body Weight; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Random Allocation; Timolol | 1982 |
The effect of a combination of timolol, hydrochlorothiazide and amiloride on 24 hour blood pressure control using ambulatory intra-arterial monitoring.
Topics: Adult; Amiloride; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Drug Combinations; Humans; Hydrochlorothiazide; Male; Middle Aged; Monitoring, Physiologic; Propanolamines; Pyrazines; Timolol | 1982 |
[Comparative study of the association of propranolol-chlorthalidone and the fixed combination of timolol-hydrochlorothiazide-amiloride in the treatment of arterial hypertension].
Topics: Amiloride; Antihypertensive Agents; Chlorthalidone; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Propranolol; Timolol | 1981 |
[Moducrin--a new combined preparation in the treatment of hypertension (author's transl)].
Topics: Adult; Amiloride; Antihypertensive Agents; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Prospective Studies; Pyrazines; Timolol | 1981 |
[Treatment of arterial hypertension: comparative study of atenolol + chlorthalidone vs. timolol maleate-hydrochlorthiazide-amiloride association].
Topics: Adult; Aged; Amiloride; Atenolol; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1981 |
Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Confidence Intervals; Databases as Topic; Diuretics; Drug Compounding; Evaluation Studies as Topic; Female; Humans; Hydrochlorothiazide; Logistic Models; Male; Metolazone; Metoprolol; Myocardial Infarction; Odds Ratio; Ontario; Propranolol; Retrospective Studies; Sex Factors; Sodium Chloride Symporter Inhibitors; Timolol | 1999 |
Chemometric determination of amiloride hydrochloride, atenolol, hydrochlorothiazide and timolol maleate in synthetic mixtures and pharmaceutical formulations.
Topics: Amiloride; Atenolol; Chemistry, Pharmaceutical; Hydrochlorothiazide; Least-Squares Analysis; Spectrophotometry, Ultraviolet; Timolol | 2004 |
[Lethal polypharmacy in a patient with arterial hypertension].
Topics: Aged; Aged, 80 and over; Amiloride; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Infarction; Diuretics; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Hypotension; Indoles; Male; Polypharmacy; Sodium Chloride Symporter Inhibitors; Timolol; Tomography, X-Ray Computed; Verapamil | 2004 |
Simultaneous spectrofluorometric analysis of tablets containing hydrochlorothiazide combined with timolol maleate or amiloride hydrochloride.
Topics: Amiloride; Drug Combinations; Hydrochlorothiazide; Limit of Detection; Reproducibility of Results; Spectrometry, Fluorescence; Tablets; Temperature; Timolol | 2020 |