hydrochlorothiazide has been researched along with probenecid in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (58.97) | 18.7374 |
| 1990's | 2 (5.13) | 18.2507 |
| 2000's | 5 (12.82) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Cragoe, EJ; deSolms, SJ; Fanelli, GM; Watson, LS; Woltersdorf, OW | 1 |
| Cragoe, EJ; deSolms, SJ; Woltersdorf, OW | 1 |
| Grassl, SM; Holtzman, EJ; Race, JE; Williams, WJ | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Beg, MA; Ragland, R | 1 |
| Jain, AK; McMahon, FG; Ryan, JR | 1 |
| Recker, RR | 1 |
| Yu, TF | 1 |
| Baer, JE; Beyer, KH | 1 |
| Barzaghi, D; Salvaterra, M; Setnikar, I; Veronese, M | 1 |
| Bonet Domingo, E; García Alvarez-Coque, MC; Medina Hernández, MJ; Ramis Ramos, G | 1 |
| Blaine, EH; Heinel, LA; Marsh, EA; Schorn, TW; Whinnery, MA | 1 |
| Damm, KH; Woermann, C | 1 |
| Kusus, T; Lydtin, H; Zöllner, N | 1 |
| Ina, K; Ito, M; Suzuki, Y; Yamagami, I | 1 |
| Boudry, JF | 1 |
| Hutchison, JC; McMahon, FG; Wilkinson, WH | 1 |
| Boudry, JF; Roch-Ramel, F | 1 |
| Garcia, DA; Yendt, ER | 1 |
| Bohn, DL; Fanelli, GM; Reilly, SS | 1 |
| Cummings, JR; Gussin, RZ; Ronsberg, MA; Stokey, EH | 1 |
| Brest, AN; Heider, C; Mehbod, H; Onesti, G | 1 |
| Freis, ED; Sappington, RF | 1 |
| BRANCACCIO, A; D'ALESSANDRO, B; DE LUCA, R; JACONO, G | 1 |
| BEISEL, WR; FORSHAM, PH; SMILO, RP | 1 |
| MASON, RM | 1 |
| Bach, MH; Simkin, PA | 1 |
2 review(s) available for hydrochlorothiazide and probenecid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Uricosuric drugs: the once and future therapy for hyperuricemia?
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Discovery; Enzyme Inhibitors; Glucose Transport Proteins, Facilitative; Gout; Humans; Hydrochlorothiazide; Hyperuricemia; Kidney Tubules, Proximal; Neoplasm Proteins; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
4 trial(s) available for hydrochlorothiazide and probenecid
| Article | Year |
|---|---|
Safety of tienilic acid.
Topics: Clinical Trials as Topic; Glycolates; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Kidney Diseases; Probenecid; Ticrynafen; Uric Acid | 1979 |
The hypouricaemic effect of tienilic acid: experience in patients with hyperuricaemia.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Double-Blind Method; Drug Administration Schedule; Female; Glycolates; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Probenecid; Ticrynafen; Uric Acid | 1979 |
[Saluretic treatment of hypertension and uric acid level in serum. Clinical test of a combination of hydrochlorothiazide and probenecid].
Topics: Adult; Aged; Alanine Transaminase; Blood Glucose; Blood Pressure; Blood Protein Electrophoresis; Body Weight; Clinical Trials as Topic; Depression, Chemical; Diabetes Mellitus; Diuretics; Female; Hemoglobins; Humans; Hydrochlorothiazide; Hypertension; Leukocyte Count; Male; Middle Aged; Natriuresis; Placebos; Potassium; Probenecid; Sodium; Uric Acid; Urticaria | 1969 |
Long-term effect of probenecid on diuretic-induced hyperuricemia.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Pressure Determination; Body Weight; Chlorthalidone; Humans; Hydrochlorothiazide; Hypertension; Kidney Tubules; Male; Middle Aged; Potassium; Probenecid; Uric Acid | 1966 |
33 other study(ies) available for hydrochlorothiazide and probenecid
| Article | Year |
|---|---|
(Acylaryloxy)acetic acid diuretics. 2. (2-Alkyl-2-aryl-1-oxo-5-indanyloxy)acetic acids.
Topics: Acetates; Animals; Chlorides; Diuretics; Dogs; Natriuresis; Pan troglodytes; Potassium; Rats; Stereoisomerism; Structure-Activity Relationship; Uricosuric Agents | 1978 |
(Acylaryloxy)acetic acid diuretics. 4. Indeno[5,4-b]furan-2-carboxylic acids.
Topics: Animals; Chemical Phenomena; Chemistry; Diuretics; Indans; Indenes; Pan troglodytes; Rats; Species Specificity; Structure-Activity Relationship; Uricosuric Agents | 1981 |
Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).
Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Biological Transport; Blotting, Northern; Carrier Proteins; Chromosomes, Human, Pair 11; Cloning, Molecular; Humans; Kidney; Mice; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Effect of hydrochlorothiazide on phosphorus during treatment with diphosphonate.
Topics: Adult; Calcium; Creatinine; Drug Interactions; Etidronic Acid; Humans; Hydrochlorothiazide; Kidney; Kidney Tubules; Male; Middle Aged; Organophosphorus Compounds; Phosphates; Phosphorus; Probenecid; Stimulation, Chemical; Time Factors | 1975 |
Pharmacokinetic and clinical studies of a new uricosuric agent - benzbromarone.
Topics: Adult; Aged; Arthritis; Benzbromarone; Benzofurans; Chemical Phenomena; Chemistry; Chronic Disease; Gout; Humans; Hydrochlorothiazide; Kinetics; Middle Aged; Probenecid; Sulfinpyrazone; Uric Acid | 1976 |
The site and mode of action of some sulfonamide-derived diuretics.
Topics: Acetazolamide; Aminohippuric Acids; Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Chlorides; Chlorothiazide; Chlorthalidone; Cyclopenthiazide; Depression, Chemical; Dichlorphenamide; Diffusion; Diuretics; Hydrochlorothiazide; Kidney Cortex; Kidney Medulla; Natriuresis; Probenecid; Rabbits; Sodium; Trichlormethiazide | 1975 |
Effects of different drugs on the urinary excretion of nifurpipone (NP) and of nitrofurantoin (NTF) in the rat.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydrochlorothiazide; Male; Nitrofurans; Nitrofurantoin; Phenobarbital; Proadifen; Probenecid; Quinine; Rats; Time Factors | 1975 |
High-performance liquid chromatographic determination of diuretics in urine by micellar liquid chromatography.
Topics: Acetazolamide; Bendroflumethiazide; Chlorothiazide; Chromatography, High Pressure Liquid; Chromatography, Liquid; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hydrochlorothiazide; Micelles; Probenecid; Sodium Dodecyl Sulfate | 1992 |
The character of the atrial natriuretic response: pressure and volume effects.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Dose-Response Relationship, Drug; Extracellular Space; Female; Furosemide; Hydrochlorothiazide; Macaca mulatta; Male; Natriuresis; Probenecid; Rats; Rats, Inbred Strains; Time Factors | 1986 |
The effect of probenecid on the in vitro absorption of cardiac glycosides.
Topics: Animals; Biological Transport; Body Water; Calcium; Cardiac Glycosides; Chromatography, Thin Layer; Digitoxin; Digoxin; Ethacrynic Acid; Furosemide; Glucose; Hydrochlorothiazide; In Vitro Techniques; Intestinal Absorption; Jejunum; Mersalyl; Mice; Mice, Inbred Strains; Osmolar Concentration; Ouabain; Oxygen Consumption; Potassium; Probenecid; Sodium; Tritium | 1974 |
[Pharmacological studies of diuretics. 4. Changes of serum uric acid level by the succesive administration of thiazide diuretics and other drugs and effects of uricosuric drugs].
Topics: Administration, Oral; Allopurinol; Ammonium Chloride; Animals; Barbiturates; Blood Glucose; Chlorothiazide; Cyclohexanes; Diuretics; Electrolytes; Ethacrynic Acid; Glycine; Hydrochlorothiazide; Hydroflumethiazide; Injections, Subcutaneous; Male; Nucleosides; Phenylbutazone; Probenecid; Quinolines; Rats; Sulfinpyrazone; Sulfonamides; Thiadiazines; Uric Acid; Uricosuric Agents; Xanthenes | 1971 |
[Effect of transtubular transport inhibitors in the renal excretion of uric acid in the rat].
Topics: Aminohippuric Acids; Animals; Hydrochlorothiazide; Kidney; Kidney Tubules; Male; Metabolic Clearance Rate; Probenecid; Rats; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1971 |
Drug-induced hyperuricemia prevented by probenecid.
Topics: Adult; Aged; Female; Gout; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Probenecid; Uric Acid | 1971 |
[Renal excretion of uric acid in rats].
Topics: Animals; Glomerular Filtration Rate; Hydrochlorothiazide; Kidney Concentrating Ability; Probenecid; Rats; Sulfinpyrazone; Uric Acid | 1969 |
The effects of probenecid and thiazides and their combination on the urinary excretion of electrolytes and on acid-base equilibrium.
Topics: Acid-Base Equilibrium; Bicarbonates; Calcium; Calcium Metabolism Disorders; Chlorides; Citrates; Drug Synergism; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentration; Kidney Calculi; Magnesium; Male; Natriuresis; Phosphorus; Potassium; Probenecid; Uric Acid | 1970 |
Renal effects of uricosuric agents in the chimpanzee.
Topics: Aminohippuric Acids; Animals; Benzoates; Benzyl Compounds; Chlorothiazide; Electrolytes; Glomerular Filtration Rate; Hominidae; Hydrochlorothiazide; Inulin; Iodopyracet; Kidney; Male; Probenecid; Sodium Salicylate; Sulfinpyrazone; Sulfonamides; Uric Acid; Uricosuric Agents; Zoxazolamine | 1971 |
CL 65,562 (4-(a,a,a-trifluoro-m-toluidino)-nicotinic acid), a novel "high ceiling" diuretic.
Topics: Acidosis; Aminohippuric Acids; Animals; Chemical Phenomena; Chemistry; Chlorides; Diuresis; Diuretics; Dogs; Female; Furosemide; Glomerular Filtration Rate; Hydrochlorothiazide; Mannitol; Nicotinic Acids; Potassium; Probenecid; Rats; Sodium; Species Specificity; Water-Electrolyte Balance | 1969 |
Drug control of diuretic-induced hyperuricemia.
Topics: Blood; Chlorothiazide; Humans; Hydrochlorothiazide; Hypertension; Probenecid; Sulfonamides; Uric Acid | 1966 |
The effect of probenecid and hydrochlorothiazide on the clearances of free and conjugated 17-hydroxycorticosteroids, total 17-ketosteroids, dehydroepiandrosterone and androsterone.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Androgens; Androsterone; Chlorothiazide; Dehydroepiandrosterone; Humans; Hydrochlorothiazide; Probenecid | 1961 |
Reversal of thiazide-induced transient hyperuricemia by uricosuric agents.
Topics: Chlorthalidone; Humans; Hydrochlorothiazide; Hyperuricemia; Probenecid; Pyrazoles; Thiazides; Uric Acid; Uricosuric Agents | 1962 |
INFLAMMATORY POLYARTHRITIC DISEASE. IV. GOUT.
Topics: Arthritis; Aspirin; Chlorothiazide; Colchicine; Gout; Hydrochlorothiazide; Mecamylamine; Pempidine; Phenylbutazone; Probenecid; Pyrazoles; Salicylates | 1963 |