hydrochlorothiazide has been researched along with metoprolol in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (41.73) | 18.7374 |
| 1990's | 23 (18.11) | 18.2507 |
| 2000's | 23 (18.11) | 29.6817 |
| 2010's | 27 (21.26) | 24.3611 |
| 2020's | 1 (0.79) | 2.80 |
| Authors | Studies |
|---|---|
| Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Avdeef, A; Tam, KY | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bauer, D; Fischer, S; Greif, D; Hauser, C; Hauser, S; Jäckel, E; Lohse, M; Löser, R; Ludwig, FA; Pietsch, M; Pietzsch, J; Pisabarro, MT; Pufe, J; Ruiz-Gómez, G; Wodtke, R; Wong, A | 1 |
| Goodfellow, R | 1 |
| Giese, J; Ibsen, H; Leth, A; McNair, A | 1 |
| Johnsson, G; Jordö, L; Lundborg, P; Persson, BA; Regärdh, CG; Rönn, O | 1 |
| Han Wan, S; Maronde, RF; Velasquez, MT | 1 |
| Goodfellow, RM | 1 |
| Pedersen, OL | 1 |
| Dahlöf, B; Ekbom, T; Hansson, L; Lindholm, LH; Scherstén, B; Wester, PO | 1 |
| Glasser, S; LaPalio, L; Schork, A; Tifft, C | 1 |
| Beck-Nielsen, H; Faergeman, O; Gall, MA; Gerdes, LU; Hommel, E; Lauritzen, M; Mathiesen, ER; Rossing, P; Skøtt, P; Vølund, A | 1 |
| Angioni, L; Botta, G; Capra, A; Leonetti, G; Mazzola, C; Pasotti, C; Vaccarella, A; Zanchetti, A | 2 |
| Barber, H; Berglund, G; Eliasson, K; Elmfeldt, D; Jastrup, B; Karatzas, N; Leer, J; Olsson, G; Tuomilehto, J; Warnold, I | 1 |
| Berglund, G | 1 |
| Atmer, B; Hjalmers, S; Leikersfeldt, G; Rasmussen, SL; Wahlqvist, I | 1 |
| Domingo, P; Gomez, JA; Jane, F; Monmany, J; Nolla, J; Roca-Cusachs, A; Sanz, F | 1 |
| Bengtsson, C; Bengtsson, L; Lapidus, L; Lundgren, H | 1 |
| Buhr-Schinner, H; Haupt, A; Kandt, M; Scheler, F; Schoel, G; Schrader, J; Schuster, S; Warneke, G | 1 |
| Behr, U; Franz, IW; Ketelhut, R; Tönnesmann, U | 2 |
| Ahmad, S; Glasser, SP; Lucas, C; Lutz, LJ; Materson, BJ; Morledge, JH; Ramanathan, KB; Saunders, E; Schnaper, HW; Vlachakis, ND | 1 |
| Lange, HH; Scherer, B; Weber, PC; Witzgall, H | 1 |
| Davies, RO; Moncloa, F; Sromovsky, JA; Walker, JF | 1 |
| Dahlöf, B; Hansson, L; Lindholm, L; Råstam, L; Scherstén, B; Wester, PO | 1 |
| Eliasson, K; Hjemdahl, P; Hylander, B; Kahan, T | 2 |
| Cox, DA; Leader, JP; Milson, JA; Singleton, W | 1 |
| Berglund, G; Elmfeldt, D; Samuelsson, O; Wikstrand, J; Wilhelmsen, L | 1 |
| Bracchetti, D; Brunelli, A; Brunelli, D; Lombardi, G; Mainardi, A; Sangiorgio, P | 1 |
| Dieckmann, MR; Hawkins, DW; Horner, RD | 1 |
| Groom, P; Peers, E; Richardson, PD; Simpson, RJ; Singh, B; Ward, DE | 1 |
| Hardarson, T; Ragnarsson, J; Snorrason, SP | 1 |
| Berglund, G; Bracchetti, D; Feldstein, CA; Kuramoto, K; Landahl, S; Meaney, E; Ming, KS; Van Couter, A; Westergren, G; Wikstrand, J | 1 |
| O'Sullivan, J | 1 |
| Barretti, P; da Silva Franco, RJ; da Silva Franco, RS; Longo, AA; Spadaro, J | 1 |
| Brewer, DD; Eltorai, MI; Priest, RT; Ricci, BA; Weber, MA | 1 |
| Bengtsson, C | 2 |
| Bigioli, F; Corti, C; Croppi, E; Imperiale, P; Livi, R; Romano, S; Scarpelli, L; Scarpelli, PT; Stinchetti, A | 1 |
| Drayer, JI; Weber, MA | 1 |
| Frishman, WH; Johnson, BF; Michelson, EL; Poland, MP | 1 |
| Smilde, JG | 1 |
| Thomas, JP; Thomson, WH | 1 |
| Dols, DM; Houtzagers, JJ; Meems, L | 1 |
| Berglund, G; Bondjers, G; Elmfeldt, D; Fager, G; Lager, I; Olofsson, SO; Smith, U; Wiklund, O | 1 |
| Adair, D; Robinson, J; Soltero, R | 1 |
| Brugger, P; Klein, G | 1 |
| Barbour, MB; Lawrie, TD; Lorimer, AR | 1 |
| Garrett, BN; Kaplan, NM; Raskin, P | 1 |
| Honkavaara, M; Nissinen, A; Tuomilehto, J | 1 |
| Dafgärd, T; Forsén, B; Lindahl, T | 1 |
| Liedholm, H; Ursing, D | 1 |
| de Oliveira, JM | 1 |
| Hansson, L; Lavenius, B | 1 |
| Jansiriskul, V; Jiamsucson, K; Lochaya, S; Srivorpongpan, R; Suvachittanont, O | 1 |
| Penman, WA; Smith, RG | 1 |
| Bravo, EL; Fouad, FM; Tarazi, RC | 1 |
| Geisler, LS | 1 |
| Novo, S; Salvia, A; Strano, A | 1 |
| Goodfellow, RM; Westberg, B | 1 |
| Avellone, G; Buzzetti, G; Davì, G; Fazio, M; Micci, S; Modica, R; Novo, S | 1 |
| Nissinen, A; Tuomilehto, J | 1 |
| Kokkinos, P; Narayan, P; Papademetriou, V | 1 |
| Abrahamsson, B; Lundborg, P; Walter, M; Wieselgren, I | 1 |
| Aurell, M; Berglund, G; Hartford, M; Lindstedt, G; Ljungman, S; Wikstrand, J | 1 |
| Beck-Nielsen, H; Faergeman, O; Gall, MA; Gerdes, LU; Hommel, EE; Lauritzen, M; Mathiesen, ER; Rossing, P; Skøtt, P; Vølund, A | 1 |
| Lacourcière, Y; Nadeau, A; Poirier, L; Tancrède, G | 1 |
| Storková, H; Válek, J; Válková, L | 1 |
| Allen, LV; Erickson, MA | 1 |
| Bartens, W; Nauck, M; Wanner, C | 1 |
| Koch, B; Stimpel, M | 1 |
| Belz, GG; Breithaupt-Grögler, K; Gerhardt, G; Lehmann, G; Notter, T | 1 |
| Airaksinen, KE; Huikuri, HV; Sellin, L; Ylitalo, A | 1 |
| Klein, G | 1 |
| Anderson, GM; Clark, JP; Gurwitz, JH; Lau, P; Rochon, PA; Shear, NH; Tu, JV | 1 |
| Fukuzawa, M; Miyaguchi, S; Nakazawa, T; Ohta, S; Qiang, X; Sakata, Y; Satoh, J; Takahashi, K; Takizawa, Y; Toyota, T | 1 |
| Bohlscheid, V; Fischer, HM; Hildemann, SK; Pittrow, D | 2 |
| Bajraktari, G; Beqiri, A; Berisha, I; Elezi, S; Kastrati, S; Manaj, R; Thaqi, S | 1 |
| Falkner, B; Francos, G; Kushner, H | 1 |
| Hainer, JW; Munzer, D; Papademetriou, V; Sugg, J | 1 |
| Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T | 1 |
| Hainer, JW; Sugg, J | 1 |
| Balwinski, KM; Mitchell, SA | 1 |
| Bakris, GL; Bell, DS; Fonseca, V; Holdbrook, FK; Iyengar, M; Katholi, RE; Lukas, MA; McGill, JB; Messerli, FH; Phillips, RA; Raskin, P; Wright, JT | 1 |
| Chen, YY; Liu, HL; Shen, FR; Sun, NL; Tao, J; Wu, HY; Xiang, XP; Yu, ZQ; Zhang, FC; Zhang, L; Zhang, WZ; Zhao, JA | 1 |
| Böhm, M; Laufs, U; Weingärtner, O | 1 |
| Chandurkar, NB; Karnik, ND; Pareek, A; Salagre, SB; Zawar, SD | 1 |
| Cui, X; Gao, F; Gu, J; Sun, Y; Wang, Z; Zhang, M | 1 |
| Chae, JB; Chong, S; Chung, SJ; Kim, DD; Lee, KR; Maeng, HJ; Shim, CK | 1 |
| Acero, JL; Benitez, FJ; Casas, F; Real, FJ; Roldan, G | 1 |
| Almeida, A; De Beer, T; Dierickx, L; Remon, JP; Saerens, L; Vervaet, C | 1 |
| Aldughaish, AM; Alnajjar, AO; Attimarad, MV; Elgorashe, RE; Idris, AM | 1 |
| Pandey, S; Parmar, S; Patel, H; Shah, D; Shah, R | 1 |
| Cammenga, M; Eeftinck Schattenkerk, DW; Stroes, ES; van den Bogaard, B; van den Born, BJ; Westerhof, BE | 1 |
| De Beer, T; Monteyne, T; Remon, JP; Saerens, L; Vervaeck, A; Vervaet, C | 1 |
| Reeder, MJ; Wood, GS | 1 |
| Vandamme, TF; Vranic, BZ | 1 |
| Bongaers, E; Lin, H; Remon, JP; Vervaet, C; Voorspoels, J; Vynckier, AK; Willart, JF; Zeitler, JA | 1 |
| Chen, Z; Hao, G; Li, Y; Ma, L; Wang, X; Wang, Z; Zhang, L; Zhao, X; Zhu, M | 1 |
| Ayyagari, R; Chen, S; Cheng, D; Huang, XY; Wu, EQ; Xie, J | 1 |
| Blaich, C; Hoffmann, F; Johannsen, JO; Müller, C; Reuter, H; Streichert, T; Wiesen, MHJ | 1 |
| Larios, J; Marshall, M; Reap, LE; Rodd, C | 1 |
| Bachmann, HS; Besser, M; Severing, AL; Stuermer, EK; Terberger, N | 1 |
| Chang, Y; Chen, X; Cheng, X; He, J; Jia, Q; Ma, W; Ouyang, H; Wei, J; Yao, G | 1 |
| Agrawal, S; Anand, J; Bachani, D; Doshi, M; Gaikwad, VB; Halder, SK; Kinholkar, B; Kumar, DA; Kumbhar, A; Mathur, R; Mehta, S; Sarkar, G; Sharma, A | 1 |
5 review(s) available for hydrochlorothiazide and metoprolol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Enalapril in hypertension and congestive heart failure. Overall review of efficacy and safety.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Enalapril; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Physical Exertion; Propranolol | 1985 |
[Exertion hypertension in coronary disease and its importance in prevention and rehabilitation].
Topics: Adult; Coronary Disease; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Myocardial Infarction; Physical Exertion; Prognosis | 1982 |
Metoprolol succinate extended release/hydrochlorothiazide combination tablets.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Delayed-Action Preparations; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Randomized Controlled Trials as Topic | 2007 |
Drug-induced pseudo-Sezary syndrome: a case report and literature review.
Topics: Adrenergic beta-1 Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomarkers; Biopsy; Diagnosis, Differential; Diuretics; Drug Eruptions; Flow Cytometry; Fosinopril; Genes, T-Cell Receptor; Humans; Hydrochlorothiazide; Immunohistochemistry; Male; Metoprolol; Middle Aged; Predictive Value of Tests; Prognosis; Sezary Syndrome; Skin; Skin Neoplasms; T-Lymphocytes | 2015 |
60 trial(s) available for hydrochlorothiazide and metoprolol
| Article | Year |
|---|---|
Bioavailability and disposition of metoprolol and hydrochlorothiazide combined in one tablet and of separate doses of hydrochlorothiazide.
Topics: Biological Availability; Drug Combinations; Half-Life; Humans; Hydrochlorothiazide; Kinetics; Metoprolol; Propanolamines; Time Factors | 1979 |
Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Potassium; Propanolamines; Substance Withdrawal Syndrome; Uric Acid | 1976 |
Antihypertensive efficacy and side effects of three beta-blockers and a diuretic in elderly hypertensives: a report from the STOP-Hypertension study.
Topics: Aged; Aged, 80 and over; Amiloride; Atenolol; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Pindolol; Prospective Studies; Treatment Outcome | 1992 |
Safety and efficacy of metoprolol in the treatment of hypertension in the elderly.
Topics: Age Factors; Aged; Blood Pressure; Clinical Protocols; Diastole; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Physicians, Family; Prospective Studies; Systole | 1992 |
Placebo-controlled comparison of captopril, metoprolol, and hydrochlorothiazide therapy in non-insulin-dependent diabetic patients with primary hypertension.
Topics: Aged; Captopril; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Hypoglycemic Agents; Lipids; Male; Metoprolol; Middle Aged | 1992 |
Treatment of hypertension in the elderly: effects on blood pressure, heart rate, and physical fitness.
Topics: Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Captopril; Female; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Physical Endurance; Physical Fitness | 1991 |
Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the MAPHY Study.
Topics: Adult; Arteriosclerosis; Bendroflumethiazide; Death, Sudden; Diuretics; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Sodium Chloride Symporter Inhibitors | 1991 |
Symptoms and well-being during antihypertensive treatment with thiazide diuretics.
Topics: Aged; Blood Pressure; Diuretics; Double-Blind Method; Female; Health Status; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Placebos; Quality of Life; Sodium Chloride Symporter Inhibitors; Substance Withdrawal Syndrome; Surveys and Questionnaires | 1990 |
Efficacy and tolerability of a fixed combination of metoprolol CR/ZOK 100 mg and hydrochlorothiazide (HCT) 12.5 mg in comparison with the fixed combination of metoprolol and HCT.
Topics: Adult; Aged; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Exercise; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Randomized Controlled Trials as Topic; Tablets | 1990 |
Effects of long-term treatment with metoprolol and hydrochlorothiazide on plasma lipids and lipoproteins.
Topics: Cholesterol; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Time Factors; Triglycerides | 1990 |
Antihypertensive drugs and glucose metabolism: comparison between a diuretic, a beta-blocker and felodipine, a new calcium antagonist in subjects with arterial hypertension and diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus; Double-Blind Method; Felodipine; Female; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged | 1990 |
[24-hour blood pressure behavior in patients with untreated and treated hypertension in comparison with normotensive patients].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitors; Circadian Rhythm; Drug Therapy, Combination; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Nitrendipine; Pindolol; Randomized Controlled Trials as Topic | 1989 |
[Regression of left heart hypertrophy in hypertensive patients as a result of antihypertensive therapy].
Topics: Acebutolol; Adult; Antihypertensive Agents; Atenolol; Cardiac Output; Cardiac Volume; Cardiomegaly; Drug Therapy, Combination; Echocardiography; Enalapril; Female; Gallopamil; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Nifedipine | 1989 |
Influence of beta 2 agonism and beta 1 and beta 2 antagonism on adverse effects and plasma lipoproteins: results of a multicenter comparison of dilevalol and metoprolol.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Cholesterol; Coronary Disease; Double-Blind Method; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Labetalol; Lipoproteins; Male; Metoprolol; Middle Aged; Multicenter Studies as Topic; Random Allocation; Risk Factors; Supination; Triglycerides | 1989 |
Does hormone analysis predict the antihypertensive response of basic medical treatment?
Topics: Adolescent; Adult; Aldosterone; Clinical Trials as Topic; Dinoprost; Dinoprostone; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Random Allocation; Renin | 1989 |
Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients.
Topics: Aged; Amiloride; Antihypertensive Agents; Captopril; Drug Evaluation; Drug Therapy, Combination; Drug Tolerance; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Physical Endurance | 1989 |
Metoprolol or hydrochlorothiazide in patients with hypertension aged 60-75 years. With special reference to assessment of compliance. Hunter Hypertension Research Group.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Patient Compliance; Potassium; Pulse; Random Allocation; Uric Acid | 1986 |
Swedish trial in old patients with hypertension. A prospective multicentre study in Swedish primary health care.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Amiloride; Atenolol; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Pindolol; Prospective Studies; Random Allocation; Sweden | 1986 |
Responses to mental stress and physical provocations before and during long term treatment of hypertensive patients with beta-adrenoceptor blockers or hydrochlorothiazide.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cyclic AMP; Epinephrine; Female; Glycerol; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Norepinephrine; Posture; Propranolol; Stress, Psychological | 1987 |
The antihypertensive effects of doxazosin: a clinical overview.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Kinetics; Male; Metoprolol; Middle Aged; Nadolol; Prazosin; Propanolamines; Random Allocation; Risk; Triglycerides | 1986 |
QRS-amplitudes during antihypertensive treatment: a comparison between beta-blocker and thiazide diuretic regimens.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; Electrocardiography; Follow-Up Studies; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Random Allocation | 1986 |
[Double-blind comparative study of the efficacy of metoprolol and hydrochlorothiazide in the elderly hypertensive. Italian results of an international multicenter study].
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Italy; Male; Metoprolol; Middle Aged; Random Allocation | 1988 |
Diuretics and hypertension in black adults.
Topics: Adult; Black People; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Random Allocation; Renin | 1988 |
A double-blind comparison of felodipine and hydrochlorothiazide added to metoprolol to control hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dizziness; Double-Blind Method; Drug Therapy, Combination; Felodipine; Female; Headache; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Nitrendipine; Random Allocation; Time Factors | 1988 |
Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker.
Topics: Aged; Amiloride; Arrhythmias, Cardiac; Bendroflumethiazide; Clinical Trials as Topic; Drug Combinations; Heart Ventricles; Humans; Hydrochlorothiazide; Hypertension; Magnesium; Male; Metoprolol; Middle Aged; Potassium; Propranolol; Random Allocation | 1987 |
Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. Report from a double-blind international multicenter study.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Patient Dropouts; Potassium; Random Allocation; Statistics as Topic; Uric Acid | 1986 |
Hypertension in the elderly.
Topics: Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol | 1985 |
[Treatment of arterial hypertension with a combination metoprolol-hydrochlorothiazide].
Topics: Blood Pressure; Clinical Trials as Topic; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Potassium; Uric Acid | 1985 |
Seven years on a selective beta-blocker - metoprolol. A long-term study of women with arterial hypertension.
Topics: Adrenergic beta-Antagonists; Alprenolol; Clinical Trials as Topic; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Middle Aged; Propanolamines | 1981 |
Single-agent and combination therapy of essential hypertension.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aldosterone; Blood Pressure; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propranolol; Renin-Angiotensin System | 1984 |
Multiclinic comparison of labetalol to metoprolol in treatment of mild to moderate systemic hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Ethanolamines; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Labetalol; Lipids; Male; Metoprolol; Middle Aged | 1983 |
Comparison of the antihypertensive effect of a double dose of metoprolol versus the addition of hydrochlorothiazide to metoprolol.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged | 1983 |
Comparison of thiazides and amiloride in treatment of moderate hypertension.
Topics: Adult; Aged; Amiloride; Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Middle Aged; Potassium; Pyrazines | 1983 |
An evaluation of the effect on resting and exercise blood pressure of some first line treatments in hypertension.
Topics: Adult; Blood Pressure Determination; Drug Combinations; Exercise Test; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Rest | 1983 |
Clinical evaluation of the antihypertensive effect of metoprolol in combination with hydrochlorothiazide and hydralazine in an unselected hypertensive population.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Lipids; Male; Metoprolol; Middle Aged; Propanolamines | 1980 |
Comparative study of hydrochlorothiazide and a fixed combination of metoprolol and hydrochlorothiazide essential hypertension.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines | 1981 |
Antihypertensive effect and tolerability of two fixed combination of metoprolol and hydrochlorothiazide followed by a long-term tolerance study with one combination.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Combinations; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines | 1981 |
[Verapamil-hydrochlorothiazide vs. metoprolol-hydrochlorothiazide. Trial in hypertensive patients].
Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Verapamil | 1981 |
A double-blind comparison of spironolactone and hydrochlorothiazide in hypertensive patients treated with metoprolol.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Spironolactone | 1982 |
Antihypertensive effects of metoprolol and reserpine-hydrochlorothiazide.
Topics: Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Random Allocation; Reserpine | 1982 |
Pilot study of antihypertensive treatment in the elderly.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Pilot Projects; Propanolamines; Random Allocation | 1982 |
[Effects of metoprolol and a combination of metoprolol and hydrochlorothiazide on arterial tension values in hypertensive patients at rest and following exertion. Crossed double-blind study].
Topics: Adult; Aged; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Physical Exertion; Propanolamines | 1981 |
Effects of diltiazem, metoprolol, enalapril and hydrochlorothiazide on frequency of ventricular premature complexes.
Topics: Analysis of Variance; Antihypertensive Agents; Cardiac Complexes, Premature; Diltiazem; Echocardiography; Electrocardiography, Ambulatory; Enalapril; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Metoprolol; Regression Analysis | 1994 |
The pharmacokinetics and pharmacodynamics of metoprolol after conventional and controlled-release administration in combination with hydrochlorothiazide in healthy volunteers.
Topics: Adult; Chemistry, Pharmaceutical; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Humans; Hydrochlorothiazide; Male; Metoprolol | 1993 |
[The effect of captopril, metoprolol and hydrochlorothiazide therapy in patients with non-insulin-dependent diabetes (NIDDM) and primary hypertension. A double-blind, randomized cross-over study].
Topics: Aged; Captopril; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged | 1993 |
Captopril or conventional therapy in hypertensive type II diabetics. Three-year analysis.
Topics: Aged; Albuminuria; Blood Pressure; Captopril; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Kidney; Male; Metoprolol; Middle Aged; Prospective Studies | 1993 |
[Glycemia increases during treatment of hypertension. 13 years' experience in the treatment of middle-aged men, randomized for treatment with beta blockers and diuretics].
Topics: Adrenergic beta-Antagonists; Blood Glucose; Blood Pressure; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Sodium Chloride Symporter Inhibitors | 1996 |
[Combination antihypertensive therapy in patients with an increased risk profile].
Topics: Adult; Aged; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Isoquinolines; Lipids; Male; Metoprolol; Middle Aged; Quinapril; Risk Factors; Tetrahydroisoquinolines; Triglycerides | 1996 |
Antihypertensive treatment with moexipril plus HCTZ vs metoprolol plus HCTZ in patients with mild-to-moderate hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Isoquinolines; Male; Metoprolol; Middle Aged; Tetrahydroisoquinolines | 1997 |
Blood pressure and aortic elastic properties--verapamil SR/trandolapril compared to a metoprolol/hydrochlorothiazide combination therapy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aorta; Blood Pressure; Bradycardia; Calcium Channel Blockers; Cough; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Metoprolol; Middle Aged; Sodium Chloride Symporter Inhibitors; Verapamil | 1998 |
Effects of combination antihypertensive therapy on baroreflex sensitivity and heart rate variability in systemic hypertension.
Topics: Aged; Antihypertensive Agents; Baroreflex; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Echocardiography, Doppler, Color; Electrocardiography, Ambulatory; Enalapril; Felodipine; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Phenylephrine | 1999 |
Combination therapy with felodipine and metoprolol compared with captopril and hydrochlorothiazide. German MC Study Group.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Captopril; Double-Blind Method; Drug Therapy, Combination; Felodipine; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged | 1998 |
Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazide combination.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Models, Statistical; Treatment Outcome; United States | 2006 |
Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study.
Topics: Adult; Aged; Antihypertensive Agents; Appetite Depressants; Blood Pressure; Body Weight; Cyclobutanes; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Felodipine; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Metoprolol; Middle Aged; Obesity; Prospective Studies; Ramipril; Treatment Outcome; Verapamil | 2007 |
Lowering blood pressure with beta-blockers in combination with other renin-angiotensin system blockers in patients with hypertension and type 2 diabetes: results from the GEMINI Trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Carbazoles; Carvedilol; Diabetes Mellitus, Type 2; Diuretics; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Renin-Angiotensin System | 2007 |
[Efficacy, safety and tolerance of Felodipine controlled release tablets and Felodipine controlled release tablets associated combination therapy in the treatment of mild to moderate essential hypertension in China].
Topics: Adult; Aged; Antihypertensive Agents; China; Delayed-Action Preparations; Drug Therapy, Combination; Felodipine; Female; Humans; Hydrochlorothiazide; Hypertension; Lisinopril; Male; Metoprolol; Middle Aged; Patient Compliance | 2007 |
Antihypertensive efficacy of metoprolol XL/low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in indian patients with mild-to-moderate essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Time Factors; Treatment Outcome | 2009 |
Lack of difference between nebivolol/hydrochlorothiazide and metoprolol/hydrochlorothiazide on aortic wave augmentation and central blood pressure.
Topics: Aged; Antihypertensive Agents; Aorta; Benzopyrans; Blood Pressure; Cross-Over Studies; Double-Blind Method; Ethanolamines; Female; Humans; Hydrochlorothiazide; Male; Metoprolol; Middle Aged; Nebivolol | 2013 |
Cost-effectiveness of nitrendipine and hydrochlorothiazide or metoprolol to treat hypertension in rural community health centers in China.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Beijing; Blood Pressure; Community Health Centers; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Health Care Costs; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Nitrendipine; Prospective Studies; Rural Health Services; Young Adult | 2017 |
Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study.
Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Coronary Artery Disease; Drug Therapy, Combination; Essential Hypertension; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Metoprolol; Telmisartan; Tetrazoles | 2022 |
62 other study(ies) available for hydrochlorothiazide and metoprolol
| Article | Year |
|---|---|
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans.
Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
N
Topics: Animals; Catalysis; Catalytic Domain; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Kinetics; Lysine; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Protein Conformation; Protein Glutamine gamma Glutamyltransferase 2; Pyridazines; Structure-Activity Relationship; Tissue Distribution; Transglutaminases | 2018 |
Dangerous antihypertensive treatment.
Topics: Adrenergic beta-Antagonists; Diuretics; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Propanolamines | 1979 |
Angiotensin II blockade during combined thiazide-beta-adrenoreceptor-blocker treatment.
Topics: Adult; Angiotensin II; Atenolol; Blood Pressure; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Plasma Volume; Propanolamines; Propranolol; Renin; Saralasin; Sodium | 1979 |
Effects of metoprolol on blood pressure and plasma renin activity in thiazide-resistant hypertensive patients.
Topics: Adult; Blood Pressure; Creatinine; Drug Resistance; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Renin; Sodium | 1979 |
A fixed combination of metoprolol and hydrochlorothiazide for hypertension: a multi-centre study.
Topics: Adult; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Potassium; Propanolamines; Pulse; Uric Acid | 1979 |
Metoprolol and hydrochlorothiazide in the treatment of elderly hypertensive patients. A Dutch multicentre trial. The Dutch Investigators Group for the Study of Antihypertensive Treatment in the Elderly.
Topics: Aged; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Random Allocation | 1988 |
Reactivity to mental stress and cold provocation during long-term treatment with metoprolol, propranolol or hydrochlorothiazide.
Topics: Adult; Blood Pressure; Catecholamines; Cold Temperature; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Propranolol; Psychological Tests; Stress, Psychological; Time Factors | 1986 |
Low-dose diuretic and beta adrenoceptor blocker in essential hypertension.
Topics: Adrenergic beta-Antagonists; Aldosterone; Analysis of Variance; Black People; Blood Pressure; Diuretics; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Posture; Potassium; Renin | 1980 |
Impairment of physical performance after treatment with beta blockers and alpha blockers.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Alprenolol; Heart Rate; Humans; Hydrochlorothiazide; Labetalol; Male; Metoprolol; Physical Exertion; Pindolol; Prazosin; Propranolol; Running | 1984 |
Assessment of optimal dose of diuretic associated with fixed dose of beta-blocking: a new experimental model based on multiple sampling of blood pressure performed by self-measurements.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Blood Pressure Determination; Diuretics; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Models, Biological | 1984 |
Slow-release metoprolol, hydrochlorothiazide and hydralazine in stepwise treatment of essential hypertension.
Topics: Adolescent; Adult; Aged; Delayed-Action Preparations; Drug Combinations; Drug Evaluation; Female; Follow-Up Studies; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged | 1984 |
Effects of anti-hypertensive therapy on serum lipoproteins. Treatment with metoprolol, propranolol and hydrochlorothiazide.
Topics: Adipose Tissue; Apolipoproteins; Blood Glucose; Catecholamines; Fatty Acids; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoprotein Lipase; Lipoproteins; Male; Metoprolol; Middle Aged; Propanolamines; Propranolol | 1983 |
Dissolution profile determination of a multicomponent product using a rapid liquid chromatographic analysis.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Combinations; Hydrochlorothiazide; Metoprolol; Solubility; Spectrophotometry, Ultraviolet | 1984 |
Metoprolol in diabetes mellitus: effect on glucose homeostasis.
Topics: Aged; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Female; Glucagon; Homeostasis; Humans; Hydrochlorothiazide; Hypertension; Insulin; Male; Metoprolol; Middle Aged; Propanolamines; Renin | 1980 |
Relation of cardiovascular response to the hypotensive effect of metoprolol.
Topics: Adult; Blood Pressure; Cardiac Output; Drug Therapy, Combination; Female; Furosemide; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines | 1982 |
[Hypertension therapy in the aged. Possibilities and chances of success].
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Child; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Prognosis | 1981 |
[Effects of metoprolol and of the combination of metoprolol and hydrochlorothiazide arterial hypertension patients].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines | 1980 |
The treatment of high blood pressure in the elderly: a multi-centre evaluation of a fixed combination of metoprolol and hydrochlorothiazide ("Co-Betaloc") in general practice.
Topics: Age Factors; Aged; Blood Pressure; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines | 1981 |
Experiences with metoprolol Durules, a slow-release formulation in hypertension.
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines | 1980 |
Effects of long-term antihypertensive treatment and aging on renal function and albumin excretion in primary hypertension.
Topics: Aging; Albuminuria; Case-Control Studies; Drug Therapy, Combination; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney; Male; Metoprolol; Middle Aged; Renal Circulation | 1993 |
[Decreasing the antihypertensive dosage during longterm treatment and complete regression of left ventricular hypertrophy].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Echocardiography; Exercise Test; Female; Heart Ventricles; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Male; Metoprolol; Prospective Studies; Treatment Outcome; Weight Loss | 1996 |
Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diuretics; Dosage Forms; Drug Compounding; Drug Stability; Humans; Hydrochlorothiazide; Labetalol; Metoprolol; Sodium Chloride Symporter Inhibitors; Spironolactone; Suspensions; Verapamil | 1996 |
Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Confidence Intervals; Databases as Topic; Diuretics; Drug Compounding; Evaluation Studies as Topic; Female; Humans; Hydrochlorothiazide; Logistic Models; Male; Metolazone; Metoprolol; Myocardial Infarction; Odds Ratio; Ontario; Propranolol; Retrospective Studies; Sex Factors; Sodium Chloride Symporter Inhibitors; Timolol | 1999 |
Modulation of tumor necrosis factor-alpha production with anti-hypertensive drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Diuretics; Doxazosin; Humans; Hydrochlorothiazide; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Metoprolol; Mice; Mice, Inbred BALB C; Monocytes; Nicardipine; Nitrobenzenes; Piperazines; Sodium Chloride Symporter Inhibitors; Tumor Necrosis Factor-alpha | 2000 |
[Antihypertensive first-line and add-on treatment with a fixed controlled release combination of metoprololsuccinate/hydrochlorothiazide. Prospective doctor's office observational study in 14,964 patients].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Delayed-Action Preparations; Diuretics; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Middle Aged; Patient Compliance; Risk Factors; Sodium Chloride Symporter Inhibitors; Tablets; Time Factors; Treatment Outcome | 2003 |
[Antihypertensive first-line and add-on treatment with a fixed controlled release combination of metoprololsuccinate/hydrochlorothiazide. Prospective doctor's office observational study in 14,964 patients].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Drug Combinations; Drug Therapy, Combination; Family Practice; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Internal Medicine; Male; Metoprolol; Middle Aged; Prospective Studies | 2003 |
Acute myocardial infarction in a patient with severe unrecognized mitral stenosis.
Topics: Analgesics; Anti-Arrhythmia Agents; Anticholesteremic Agents; Anticoagulants; Aspirin; Atrial Fibrillation; Diuretics; Echocardiography, Transesophageal; Electrocardiography; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Hydrochlorothiazide; Metoprolol; Middle Aged; Mitral Valve Stenosis; Myocardial Infarction; Nadroparin; Simvastatin; Time Factors; Treatment Outcome | 2006 |
Metoprolol succinate, a selective beta-adrenergic blocker, has no effect on insulin sensitivity.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Cholesterol; Cholesterol, LDL; Female; Glucose Clamp Technique; Humans; Hydrochlorothiazide; Hypertension; Insulin Resistance; Male; Metoprolol | 2006 |
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets.
Topics: Acetaminophen; Caffeine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Excipients; Hydrochlorothiazide; Hypromellose Derivatives; Ketoprofen; Methylcellulose; Metoprolol; Molecular Weight; Particle Size; Solubility; Tablets; Theophylline; Viscosity | 2007 |
[67-year-old patient with abdominal pain and pronounced peritonitis].
Topics: Abdominal Pain; Aged; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Ascites; Coronary Disease; Diagnosis, Differential; Edema; Female; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Peritonitis; Pharyngeal Diseases; Respiratory Insufficiency; Tomography, X-Ray Computed | 2009 |
Simultaneous quantitation of hydrochlorothiazide and metoprolol in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Administration, Oral; Antihypertensive Agents; Calibration; Chromatography, Liquid; Drug Combinations; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentration; Male; Metoprolol; Observer Variation; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry | 2010 |
Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway.
Topics: 1-Methyl-4-phenylpyridinium; Administration, Intranasal; Animals; Area Under Curve; Biological Transport; Blood-Brain Barrier; Brain; Chemical Phenomena; Donepezil; Gene Expression; HEK293 Cells; Humans; Hydrochlorothiazide; Indans; Linear Models; Male; Metoprolol; Nootropic Agents; Ofloxacin; Olfactory Mucosa; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; p-Aminohippuric Acid; Pharmaceutical Preparations; Pharmacokinetics; Piperidines; Ranitidine; Rats; Rats, Sprague-Dawley; Transfection | 2010 |
Bromination of selected pharmaceuticals in water matrices.
Topics: Amoxicillin; Halogenation; Hydrochlorothiazide; Hydrogen-Ion Concentration; Kinetics; Metoprolol; Naproxen; Pharmaceutical Preparations; Phenacetin; Water Pollutants, Chemical | 2011 |
Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices.
Topics: Adrenergic beta-1 Receptor Antagonists; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Delayed-Action Preparations; Diuretics; Drug Combinations; Drug Compounding; Excipients; Hot Temperature; Hydrochlorothiazide; Metoprolol; Polyesters; Polyethylene Glycols; Spectrum Analysis, Raman; Tablets; Time Factors; X-Ray Diffraction | 2012 |
Capillary electrophoresis assay method for metoprolol and hydrochlorothiazide in their combined dosage form with multivariate optimization.
Topics: Drug Combinations; Electrophoresis, Capillary; Hydrochlorothiazide; Limit of Detection; Metoprolol; Multivariate Analysis; Reproducibility of Results; Tablets | 2013 |
Formulation development of metoprolol succinate and hydrochlorothiazide compression coated tablets.
Topics: Antihypertensive Agents; Delayed-Action Preparations; Diffusion; Drug Compounding; Drug Stability; Drug Storage; Excipients; Hydrochlorothiazide; Hydrogen-Ion Concentration; Hypromellose Derivatives; Methylcellulose; Metoprolol; Pharmacopoeias as Topic; Polyethylene Glycols; Polymers; Tablets | 2013 |
Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations.
Topics: Adrenergic beta-1 Receptor Antagonists; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Diuretics; Dosage Forms; Fatty Acids; Hydrochlorothiazide; In Vitro Techniques; Metoprolol; Particle Size; Polyethylene Glycols; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman | 2014 |
Preliminary study of an offline simultaneous determination of metoprolol tartrate and hydrochlorothiazide in powders and tablets by reflectance near-infrared spectroscopy.
Topics: Calibration; Hydrochlorothiazide; Metoprolol; Powders; Reference Standards; Spectroscopy, Near-Infrared; Tablets | 2015 |
Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion.
Topics: Calorimetry, Differential Scanning; Delayed-Action Preparations; Drug Carriers; Drug Combinations; Drug Liberation; Hydrochlorothiazide; Metoprolol; Solubility; Tablets; Technology, Pharmaceutical; X-Ray Diffraction; X-Ray Microtomography | 2015 |
A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Nebivolol; Random Allocation; Retrospective Studies; Treatment Outcome | 2018 |
Reliable and easy-to-use LC-MS/MS-method for simultaneous determination of the antihypertensives metoprolol, amlodipine, canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension.
Topics: Amlodipine; Antihypertensive Agents; Canrenone; Carbon Isotopes; Chromatography, High Pressure Liquid; Deuterium; Drug Monitoring; Drug Resistance; Humans; Hydrochlorothiazide; Hypertension; Limit of Detection; Male; Metoprolol; Middle Aged; Reproducibility of Results; Tandem Mass Spectrometry | 2019 |
Hydrochlorothizide-induced acute generalised exanthematous pustulosis presenting with bilateral periorbital impetigo.
Topics: Acute Generalized Exanthematous Pustulosis; Administration, Topical; Aged, 80 and over; Anti-Infective Agents; Betamethasone; Drug-Related Side Effects and Adverse Reactions; Eye Diseases; Female; Glucocorticoids; Humans; Hydrochlorothiazide; Impetigo; Metoprolol; Treatment Outcome | 2019 |
Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Cell Line; Cell Movement; Diuretics; Fibroblasts; Humans; Hydrochlorothiazide; Keratinocytes; Metoprolol; Ramipril; Tetrazoles; Wound Healing | 2019 |
A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats.
Topics: Animals; Antihypertensive Agents; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; High-Throughput Screening Assays; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Rats; Tandem Mass Spectrometry | 2019 |