hydrochlorothiazide and doxazosin

hydrochlorothiazide has been researched along with doxazosin in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19905 (18.52)18.7374
1990's10 (37.04)18.2507
2000's7 (25.93)29.6817
2010's3 (11.11)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Andricopulo, AD; Moda, TL; Montanari, CA1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Agabiti-Rosei, E; Beschi, M; Calebich, S; Castellano, M; Muiesan, G; Muiesan, ML; Rizzoni, D; Zulli, R1
Nelson, EB; Pool, JL; Taylor, AA1
Pool, JL1
Claessens, J; Nelemans, F; Riesen, W; Streulens, Y; Trost, BN; Weidmann, P1
Cox, DA; Leader, JP; Milson, JA; Singleton, W1
Daae, L; Hjermann, I; Hjortdahl, P; Holme, I; von Krogh, H1
Jones, DW; Sands, CD1
Agbedana, EO; Ahaneku, JE; Salako, LA; Taylor, GO; Walker, O1
Carruthers, G; Dessain, P; Fodor, G; Newman, C; Palmer, W; Sim, D1
Agbedana, OE; Ahaneku, JE; Taylor, OG1
Flack, JM; Gonzalez, NM; Grimm, RH; Liebson, PR; Schoenberger, JA1
Ahaneku, JE1
Agbedana, EO; Ahaneku, JE; Salako, LA; Sowunmi, A; Taylor, GO; Walker, O1
Half-Onn, E; Levi, Z; Rachmani, R; Ravid, M; Slavachevsky, I1
Ritz, E; Schwenger, V; Zeier, M1
Fukuzawa, M; Miyaguchi, S; Nakazawa, T; Ohta, S; Qiang, X; Sakata, Y; Satoh, J; Takahashi, K; Takizawa, Y; Toyota, T1
Birkenhägeri, JC; de Groot, E; de Heide, LH; de Ridder, MA; Hoogerbrugge, N; Jansen, H; Stijnen, T1
Alcázar, JM; Campo, C; Rodicio, JL; Roldán, C; Ruilope, LM; Segura, J1
Dobrokhod, AS; Kushnir, SM; Radchenko, GD; Sirenko, YM; Torbas, OO1
Brown, MJ; Caulfield, M; Cruickshank, JK; Ford, I; MacDonald, TM; Mackenzie, IS; McCann, GP; McInnes, G; Morant, S; Padmanabhan, S; Salsbury, J; Sever, P; Webb, DJ; Williams, B1
Böhm, M; Götzinger, F; Hohl, M; Hübner, U; Lauder, L; Lehnert, U; Mahfoud, F; Meyer, MR; Schneider, C; Sevimli, Ö; Tokcan, M; Wagmann, L1

Reviews

2 review(s) available for hydrochlorothiazide and doxazosin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Review of the effects of doxazosin, a new selective alpha 1-adrenergic inhibitor, on lipoproteins in patients with essential hypertension.
    The American journal of medicine, 1989, Aug-16, Volume: 87, Issue:2A

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Doxazosin; Humans; Hydrochlorothiazide; Hypertension; Lipoproteins; Prazosin

1989

Trials

16 trial(s) available for hydrochlorothiazide and doxazosin

ArticleYear
Plasma lipid lowering effects of doxazosin, a new selective alpha1 adrenergic inhibitor for systemic hypertension.
    The American journal of cardiology, 1987, May-29, Volume: 59, Issue:14

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Double-Blind Method; Doxazosin; Humans; Hydrochlorothiazide; Hypertension; Lipids; Placebos; Prazosin

1987
Comparative effects of doxazosin and hydrochlorothiazide on serum lipids and blood pressure in essential hypertension.
    The American journal of cardiology, 1987, May-29, Volume: 59, Issue:14

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male; Middle Aged; Prazosin; Prospective Studies; Random Allocation

1987
The antihypertensive effects of doxazosin: a clinical overview.
    British journal of clinical pharmacology, 1986, Volume: 21 Suppl 1

    Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Kinetics; Male; Metoprolol; Middle Aged; Nadolol; Prazosin; Propanolamines; Random Allocation; Risk; Triglycerides

1986
A 24-week multicenter double-blind study of doxazosin and hydrochlorothiazide in patients with mild to moderate essential hypertension.
    Acta medica Scandinavica, 1987, Volume: 221, Issue:5

    Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male; Middle Aged; Prazosin; Random Allocation; Time Factors

1987
Effects of doxazosin and hydrochlorothiazide on lipid levels in Korean patients with essential hypertension.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:3

    Topics: Adult; Aged; Blood Pressure; Cholesterol, HDL; Cholesterol, LDL; Diet; Double-Blind Method; Doxazosin; Female; Humans; Hydrochlorothiazide; Hypertension; Korea; Lipids; Male; Middle Aged; Triglycerides

1993
Changes in lipid and lipoprotein values during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients.
    JPMA. The Journal of the Pakistan Medical Association, 1994, Volume: 44, Issue:7

    Topics: Adult; Aged; Amiloride; Amlodipine; Antihypertensive Agents; Cross-Over Studies; Double-Blind Method; Doxazosin; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins; Middle Aged

1994
Comparative trial of doxazosin and atenolol on cardiovascular risk reduction in systemic hypertension. The Alpha Beta Canada Trial Group.
    The American journal of cardiology, 1993, Mar-01, Volume: 71, Issue:7

    Topics: Adult; Aged; Atenolol; Cholesterol; Cholesterol, HDL; Coronary Disease; Double-Blind Method; Doxazosin; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prospective Studies; Risk Factors

1993
Relationship between body mass index (BMI) and changes in plasma total and HDL-cholesterol levels during treatment of hypertension in African patients.
    Acta medica Okayama, 1995, Volume: 49, Issue:5

    Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Black People; Body Mass Index; Cholesterol; Cholesterol, HDL; Doxazosin; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nigeria

1995
Alpha-blockade and thiazide treatment of hypertension. A double-blind randomized trail comparing doxazosin and hydrochlorothiazide.
    American journal of hypertension, 1996, Volume: 9, Issue:5

    Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Double-Blind Method; Doxazosin; Echocardiography; Female; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male; Middle Aged; Patient Compliance; Pulse; Quality of Life; Sodium Chloride Symporter Inhibitors

1996
Blood pressure and blood glucose levels during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients.
    The Kobe journal of medical sciences, 1996, Volume: 42, Issue:1

    Topics: Adult; Aged; Amiloride; Amlodipine; Antihypertensive Agents; Blood Glucose; Blood Pressure; Cross-Over Studies; Doxazosin; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Treatment Outcome

1996
Biochemical changes during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients.
    JPMA. The Journal of the Pakistan Medical Association, 1996, Volume: 46, Issue:4

    Topics: Adult; Aged; Amiloride; Amlodipine; Antihypertensive Agents; Blood Proteins; Calcium; Creatinine; Cross-Over Studies; Double-Blind Method; Doxazosin; Drug Combinations; Electrolytes; Humans; Hydrochlorothiazide; Hypertension; Middle Aged

1996
Effect of an alpha-adrenergic blocker, and ACE inhibitor and hydrochlorothiazide on blood pressure and on renal function in type 2 diabetic patients with hypertension and albuminuria. A randomized cross-over study.
    Nephron, 1998, Volume: 80, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Cilazapril; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Doxazosin; Female; Humans; Hydrochlorothiazide; Hypertension; Kidney Function Tests; Male; Middle Aged

1998
Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study). Doxazosin Atherosclerosis Progression Study in Hypertensives in the Netherlands.
    The Netherlands journal of medicine, 2002, Volume: 60, Issue:9

    Topics: Aged; Antihypertensive Agents; Arteriosclerosis; Carotid Arteries; Disease Progression; Diuretics; Double-Blind Method; Doxazosin; Femoral Artery; Humans; Hydrochlorothiazide; Hypercholesterolemia; Hypertension; Male; Middle Aged; Sodium Chloride Symporter Inhibitors

2002
Doxazosin GITS versus hydrochlorothiazide as add-on therapy in patients with uncontrolled hypertension.
    Blood pressure. Supplement, 2003, Volume: 2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cholesterol; Doxazosin; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Treatment Outcome; Uric Acid

2003
Comparative effectiveness of a fixed-dose combination of losartan + HCTZ versus bisoprolol + HCTZ in patients with moderate-to-severe hypertension: results of the 6-month ELIZA trial.
    Vascular health and risk management, 2013, Volume: 9

    Topics: Adrenergic beta-1 Receptor Antagonists; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Bisoprolol; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Chi-Square Distribution; Diuretics; Doxazosin; Drug Combinations; Drug Therapy, Combination; Electrocardiography; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Pulse Wave Analysis; Severity of Illness Index; Time Factors; Treatment Outcome; Ukraine; Vascular Stiffness

2013
Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.
    Journal of the American Heart Association, 2017, Nov-18, Volume: 6, Issue:11

    Topics: Adolescent; Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Doxazosin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Treatment Outcome; Young Adult

2017

Other Studies

9 other study(ies) available for hydrochlorothiazide and doxazosin

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Reduction of left ventricular hypertrophy after longterm antihypertensive treatment with doxazosin.
    Journal of human hypertension, 1992, Volume: 6, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adult; Aldosterone; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Catecholamines; Diastole; Dose-Response Relationship, Drug; Doxazosin; Drug Therapy, Combination; Female; Heart Rate; Heart Ventricles; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male; Middle Aged; Organ Size; Prazosin; Renin; Rest; Stress, Physiological; Systole; Time Factors

1992
Antihypertensive therapy in renal patients - benefits and difficulties.
    Nephron, 1999, Volume: 83, Issue:3

    Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Captopril; Diuretics; Doxazosin; Humans; Hydrochlorothiazide; Hypertension, Renal; Kidney Failure, Chronic; Kidney Glomerulus; Male; Nitrendipine; Proteinuria; Renal Circulation; Triamterene

1999
Modulation of tumor necrosis factor-alpha production with anti-hypertensive drugs.
    Immunopharmacology, 2000, Volume: 48, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Diuretics; Doxazosin; Humans; Hydrochlorothiazide; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Metoprolol; Mice; Mice, Inbred BALB C; Monocytes; Nicardipine; Nitrobenzenes; Piperazines; Sodium Chloride Symporter Inhibitors; Tumor Necrosis Factor-alpha

2000
Efficacy of Antihypertensive Drugs of Different Classes After Renal Denervation in Spontaneously Hypertensive Rats.
    Hypertension (Dallas, Tex. : 1979), 2023, Volume: 80, Issue:6

    Topics: Aldosterone; Amlodipine; Animals; Antihypertensive Agents; Bisoprolol; Blood Pressure; Cardiomyopathies; Denervation; Doxazosin; Hydrochlorothiazide; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Renin; Sympathectomy

2023