hydrazine and sq 29548
hydrazine has been researched along with sq 29548 in 503 studies
Research
Studies (503)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 88 (17.50) | 18.7374 |
| 1990's | 234 (46.52) | 18.2507 |
| 2000's | 137 (27.24) | 29.6817 |
| 2010's | 42 (8.35) | 24.3611 |
| 2020's | 2 (0.40) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Diederich, A; Diederich, D; Fu-Xiang, D; Jameson, M; Skopec, J | 1 |
| Chiyotani, A; Isono, K; Kondo, M; Konno, K; Sakai, N; Tamaoki, J | 1 |
| Hunt, JA; Keen, M; MacDermot, J; Merritt, JE | 1 |
| Cohen, RA; Tesfamariam, B | 1 |
| Fitzpatrick, F; Hill, E; Murphy, RC | 1 |
| Campbell, WB; Pfister, SL | 1 |
| Ishii, A; Miki, I; Nonaka, H | 1 |
| Gutierrez, G; Hazle, JD; Ogletree, ML; Pettigrew, LC; Smith, CD | 1 |
| Darius, H; Meyer, J; Michael-Hepp, J | 1 |
| Badr, KF; Ebert, J; Fukunaga, M; Hoover, RL; Morrow, JD; Nammour, TM; Roberts, LJ; Takahashi, K | 1 |
| Hedberg, A; Monshizadegan, H; Webb, ML | 1 |
| Brune, KA; Dubé, GP; Jakubowski, JA; Kurtz, WL; Mais, DE; Rinkema, LE; True, TA; Utterback, BG | 1 |
| Mayhan, WG | 2 |
| Ishii, A; Miki, I | 1 |
| Armstrong, ML; Densen, P; Heistad, DD; Lopez, JA; Mügge, A; Padgett, RC; Piegors, DJ | 1 |
| Ishii, A; Kase, H; Miki, I | 1 |
| Ishii, A; Kishibayashi, N; Miki, I; Nonaka, H; Obase, H; Ohshima, E; Takami, H | 1 |
| Fenoy, FJ; Nasjletti, A; Roman, RJ; Yamaguchi, Y | 1 |
| Boyd, VL; Harbison, R; Kadowitz, PJ; Kvamme, P; McNamara, DB | 1 |
| Allen, GT; Ogletree, ML | 1 |
| Lagarde, M; Le Breton, GC; Parent, CA; Venton, DL | 1 |
| Allen, GT; Floyd, DM; Goldenberg, HJ; Hall, SE; Han, WC; Harris, DN; Hartl, KS; Michel, IM; Schumacher, WA; Steinbacher, TE | 1 |
| Hood, JS; Hyman, AL; Kadowitz, PJ; McMahon, TJ; Nossaman, BD | 1 |
| Dieter, JP; Knezevic, I; Le Breton, GC | 1 |
| Ibe, BO; Raj, JU; Toga, H | 1 |
| Goldman, G; Hechtman, HB; Klausner, JM; Shepro, D; Valeri, CR; Welbourn, R | 1 |
| Higashihara, M; Ishii, A; Miki, I; Nakao, A; Ogura, M; Saito, H; Seyama, Y; Sunaga, S; Watanabe, T; Yatomi, Y | 1 |
| Anderson, HV; Benedict, CR; Buja, LM; Campbell, WB; Cui, K; Maffrand, JP; McNatt, J; Ober, JC; Rosolowsky, M; Yao, SK | 1 |
| Hall, SE; Kim, SO; Komiotis, D; Lam, SC; Le Breton, GC; Lim, CT; Venton, DL | 1 |
| Banerjee, M; Biaggioni, I; Fukushima, M; Kang, KH; King, LS; Newman, JH | 1 |
| Mayhan, WG; Sharpe, GM; Simmons, LK | 1 |
| Halushka, PV; Mais, DE; Masuda, A; Morinelli, TA; Naka, M; Oatis, JE; Okwu, AK; Saussy, DL | 1 |
| Fitzgerald, DJ; Fitzgerald, GA; Furci, L | 1 |
| Baron, DA; Halushka, PV; Hazard, ES; Mais, DE; Mayeux, PR; Morinelli, TA; Oatis, JE; Williams, TC | 1 |
| Doyle, K; Feller, DR; Gerhardt, MA; Harrold, MW; Miller, DD; Patil, PN; Romstedt, KJ; Shin, Y | 1 |
| Cahill, BE; Haile, DM; Kadowitz, PJ; Neely, CF | 1 |
| Bagchus, WM; Bresnahan, BA; Lianos, EA; Roman, RJ | 1 |
| Faul, C; Jaschonek, K; Renn, W | 1 |
| Bellan, JA; Kadowitz, PJ; McMahon, TJ; McNamara, DB; Minkes, RK | 1 |
| Feng, CJ; Hood, JS; Ibrahim, IN; Kadowitz, PJ; McMahon, TJ; Nossaman, BD | 1 |
| Snellen, H; Welch, WJ; Wilcox, CS | 1 |
| Cockerham, C; Hedberg, SA; Runge, MS; Webb, ML | 1 |
| Lin, L; Nasjletti, A | 1 |
| Miller, FN; Reed, MW; Schuschke, DA | 1 |
| Clark, JE; Harder, DR; Kauser, K; Ma, YH; Masters, BS; Ortiz de Montellano, PR; Roman, RJ | 1 |
| Brown, BR; Hall, SE; Han, WC; Harris, DN; Hedberg, A; Misra, RN; Webb, ML | 1 |
| Abe, MT; Nakahata, N; Nakanishi, H; Sato, K | 1 |
| Lin, L; Mistry, M; Nasjletti, A; Stier, CT | 1 |
| Feinberg, H; Lee, SL; Levitsky, S | 1 |
| Adeagbo, AS; Malik, KU | 1 |
| Amsterdam, EA; Longhurst, JC; Stahl, GL; Symons, JD | 1 |
| Aksoy, MO; Harakal, C; Smith, JB; Stewart, GJ; Zerweck, CR | 1 |
| Cyran, JA; Lea, MA; Lysz, TW | 1 |
| Baudendistel, LJ; Bradley, JD; Dahms, TE; Webster, RO; Zanaboni, PB | 1 |
| Badr, KF; Harris, RC; Munger, KA; Takahashi, K | 1 |
| Mok, LL; Reynolds, EE | 1 |
| Fitzgerald, DJ; FitzGerald, GA; Murray, R; Takahara, K | 1 |
| Mistry, M; Nasjletti, A | 3 |
| Feller, DR; Miller, DD; Shams, G; Wallace, LJ | 1 |
| Felsen, D; Loo, MH; Marion, DN; Vaughan, ED | 1 |
| Bech, FR; Cronenwett, JL; Freeman, DH; McDaniel, MD; Ogletree, ML | 1 |
| Anderson, HV; Buja, LM; De Clerck, F; Golino, P; NcNatt, JM; Rosolowsky, M; Willerson, JT; Yao, SK | 1 |
| Buja, LM; De Clerck, F; Golino, P; McNatt, J; Rosolowsky, M; Willerson, JT; Yao, SK | 1 |
| Le Breton, GC; Lim, CT; Vaidya, CM; Venton, DL | 1 |
| Fasciolo, JC; Lama, MC; Nolly, H; Vargas, L | 1 |
| Sato, K | 1 |
| Mistry, M; Muirhead, EE; Nasjletti, A; Yamaguchi, Y | 1 |
| Cappelli-Bigazzi, M; Harrison, DG; Lamping, KG; Nuno, DW | 1 |
| Nieves, AL; Williams, LS; Woodward, DF | 1 |
| Conger, JD; Robinette, JB | 1 |
| Anderson, CB; Halstead, M; Jendrisak, MD; Mangino, MJ; Murphy, MK | 1 |
| Busija, DW; Wagerle, LC | 1 |
| Welch, WJ; Wilcox, CS | 3 |
| Arita, H; Hanasaki, K; Kishi, M | 1 |
| McCall, CE; Salzer, WL | 1 |
| Armstead, WM; Higuera, TR; Kadowitz, PJ; Lepak, KA; Lippton, HL; McNamara, DB; Minkes, RK | 1 |
| Alemayehu, A; Chou, CC | 2 |
| Hock, CE; Lefer, AM; Whitney, CC | 1 |
| Brezinski, ME; Lefer, AM; Yanagisawa, A | 1 |
| Hyman, AL; Kadowitz, PJ; Kriseman, T; McNamara, DB; Underwood, DC | 1 |
| Grover, GJ; Schumacher, WA | 1 |
| Stürzebecher, S; Witt, W | 1 |
| Gabriel, D; Prior, G; Schillinger, E; Thierauch, KH | 1 |
| Stein, EA; Trachte, GJ | 2 |
| Ashton, JH; Buja, LM; Glas-Greenwalt, P; Golino, P; McNatt, J; O'Brien, RA; Willerson, JT; Yao, SK | 1 |
| Arita, H; Hanasaki, K; Nakano, T | 1 |
| Baker, R; Cassin, S; Davis, T; Gause, G; ter Riet, M | 1 |
| Escalante, B; Falck, JR; Schwartzman, ML; Yadagiri, P | 1 |
| Dunbar, KR; Welch, WJ; Wilcox, CS | 1 |
| Lawson, DL; Mehta, JL; Mehta, P; Nichols, WW | 1 |
| Ashton, JH; Buja, LM; Golino, P; McNatt, JM; Willerson, JT | 1 |
| Hedberg, A; Hollander, AM; Liu, EC; Mento, PF; Wilkes, BM | 1 |
| McGiff, JC; Nasjletti, A; Quilley, J | 1 |
| Fujimoto, M; Hara, S; Ide, M; Mihara, S; Ueda, M | 2 |
| Maita, M; Mento, PF; Solomon, J; Wilkes, BM | 1 |
| Hyman, AL; Kadowitz, PJ; McNamara, DB; Tilden, SJ; Underwood, DC | 1 |
| Cook, JA; Halushka, PV; Heffner, JE | 1 |
| Akar, F; Kanzik, I | 1 |
| Goldman, G; Hechtman, HB; Klausner, JM; Kobzik, L; Paterson, IS; Shepro, D; Valeri, CR; Welbourn, R | 1 |
| Arita, H; Hanasaki, K; Kasai, H; Nakano, K | 1 |
| Armstead, WM; Busija, DW; Leffler, CW; Mirro, R | 1 |
| Franzini, D; Lawson, D; Mehta, J; Nichols, WW; Wargovich, TJ | 1 |
| Matsuoka, I; Nakahata, N; Nakanishi, H; Ono, T | 1 |
| Bernardini, R; Calogero, AE; Chiarenza, A; Chrousos, GP; Gold, PW | 1 |
| Bradley, LM; Czaja, JF; Goldstein, RE; Stambouly, JJ | 1 |
| Woods, LL | 1 |
| Allison, P; Ashton, J; Buja, LM; Eidt, JF; Golino, P; McNatt, J; Noble, S; Willerson, JT | 2 |
| Ikeda, K; Sasaki, H; Sasaki, T; Shimura, S; Takishima, T | 1 |
| Aramburo, MJ; Hammerman, C; Hill, V | 1 |
| Goldman, G; Hechtman, HB; Klausner, JM; Kobzik, L; Paterson, IS; Shepro, D; Valeri, CR | 1 |
| Bellan, JA; Graybar, GB; Harrington, JK; Kadowitz, PJ; McNamara, DB; Underwood, DC | 1 |
| Kakushi, H; Shike, T; Uchida, K | 1 |
| Kadowitz, PJ; Underwood, DC | 1 |
| Bradley, LM; Feuerstein, G; Goldstein, RE | 1 |
| Blair, IA; Cragoe, EJ; Frazer, M; Limbird, LE; Reed, PW; Schwartzberg, MS; Sweatt, JD | 1 |
| Daniel, EE; Serio, R | 1 |
| Regal, JF | 1 |
| Boehm, A; Halushka, PV; Mais, DE | 1 |
| Bradley, LM; Czaja, JF; Feuerstein, G; Goldstein, RE | 1 |
| Grover, GJ; Parham, CS | 1 |
| Darius, H; Lefer, AM | 2 |
| Darius, H; Lefer, AM; Stahl, GL | 1 |
| Brown, JA; Zipser, RD | 1 |
| Adams, HD; Ogletree, ML; Schumacher, WA | 1 |
| Bolds, JM; FitzGerald, GA; Kühl, PG; Loyd, JE | 1 |
| Arita, H; Doteuchi, M; Hanasaki, K; Kasai, H; Nakano, K; Ohtani, K | 1 |
| Bolds, JM; FitzGerald, GA; Kühl, PG; Loyd, JE; Snapper, JR | 1 |
| Arita, H; Hanasaki, K; Kasai, H; Kurihara, H; Nakano, K | 1 |
| Hall, SE; Harris, DN; Hedberg, A; Liu, EC; Ogletree, ML | 1 |
| Grover, GJ; Parham, C; Sleph, PG | 1 |
| Darius, H; Lefer, AM; Smith, JB | 1 |
| Doran, J; Fitzgerald, DJ; FitzGerald, GA; Jackson, E | 1 |
| Trachte, GJ | 1 |
| Brezinski, ME; Hock, CE; Lefer, AM | 1 |
| Graf, PD; Nadel, JA; Osborne, ML; Sekizawa, K; Tamaoki, J; Ueki, IF | 1 |
| Hyman, AL; Kadowitz, PJ; Kriseman, T; Underwood, DC | 1 |
| Ashton, JH; Buja, LM; Glas-Greenwalt, P; Golino, P; McNatt, J; Willerson, JT | 1 |
| Myers, AK; Nakanishi, T; Ramwell, P | 1 |
| Bjøro, K; Stray-Pedersen, S | 1 |
| Kaldunski, ML; Mattson, DL; Mistry, M; Nasjletti, A; Roman, RJ | 1 |
| Fulmor, IE; Grover, GJ | 1 |
| Hollenberg, NK; Monteiro, K; Sandor, T | 1 |
| Mento, PF; Wilkes, BM | 1 |
| Ashton, JH; Buja, LM; Golino, P; Kulkarni, P; Taylor, A; Willerson, JT | 1 |
| Campbell, PB; Tolson, TA | 1 |
| Kimura, A; Lawson, D; Lee-Ambrose, L; Mehta, P; Ward, MB | 1 |
| Chignard, M; Selak, MA; Smith, JB | 1 |
| Gann, DS; Handy, JR; Hulstyn, M; Husain, SE; Slotman, GJ; Yellin, SA | 1 |
| Kot, PA; Maddox, YT; Ramwell, PW; Van Dam, J | 1 |
| Bigby, TD; Graf, PD; Nadel, JA; Sekizawa, K; Tamaoki, J; Ueki, IF | 1 |
| Lawson, D; Mehta, J; Mehta, P; Ward, MB | 1 |
| Keith, RA; Salama, AI | 1 |
| Olson, RW; Smith, EF | 1 |
| Lefer, AM; Smith, JB; Yanagisawa, A; Zipkin, R | 1 |
| Foegh, ML; Melki, TS; Ramwell, PW | 1 |
| Farrugia, R; Slotman, GJ; Teplitz, C; Yellin, SA | 1 |
| Greenberg, R; Liu, EC; O'Keefe, EH; Ogletree, ML | 1 |
| Greenberg, R; Harris, DN; Haslanger, MF; Nakane, M; Ogletree, ML | 1 |
| Kojima, C; Muramatsu, M; Tanabe, H; Tanaka, M | 1 |
| Brooks, LA; Dellsperger, KC; Eller, BT | 1 |
| Taddei, S; Vanhoutte, PM | 2 |
| Mehta, JL; Yang, BC | 1 |
| Murai, A; Nakahata, N; Nakamura, H; Ohizumi, Y; Rho, MC | 1 |
| Andrews, S; Chen, J; De Vries, GW; Guarino, P; McLaughlin, A; Woodward, DF | 1 |
| Brown, ML; Cohen, RA; Tesfamariam, B | 1 |
| Abe, K; Abe, T; Takahashi, N; Takeuchi, K; Taniyama, Y; Tsutsumi, E | 1 |
| Bochnowicz, S; Underwood, DC | 1 |
| Bertolino, F; Bessac, AM; Colpaert, FC; Delhon, A; Grelac, F; Lévy-Toledano, S; Maclouf, J; Maffre, M; Patoiseau, JF; Valentin, JP | 1 |
| Hay, DW; Hubbard, WC; Undem, BJ | 1 |
| Bayon, Y; Chirouze, V; Croset, M; Daveloose, D; Guerbette, F; Kader, JC; Lagarde, M; Viret, J | 1 |
| Grosser, T; Halushka, PV; Morinelli, T; Sachinidis, A; Schrör, K; Vetter, H; Zucker, TP | 1 |
| Bird, JE; Waldron, TL | 1 |
| Gibson, RL; Murphy, TD; Standaert, TA; Woodrum, DE | 1 |
| Kurahashi, K; Nishimura, Y; Suzuki, A; Usui, H | 1 |
| Conger, JD; Falk, SA; Lanese, DM | 1 |
| Craven, PA; DeRubertis, FR; Studer, RK | 2 |
| Folger, WH; Welch, WJ; Wilcox, CS | 1 |
| Bemis, KG; Brune, KA; Dubé, GP; Jakubowski, JA; Kurtz, WL | 1 |
| Batra, V; Haile, D; Matot, I; Neely, CF; Nguyen, J | 1 |
| Bertolino, F; Bessac, AM; John, GW; Maffre, M; Valentin, JP | 1 |
| Beck, LD; Briglia, FA; Hock, CE; Patel, JP | 1 |
| Longmire, AW; Morrow, JD; Roberts, LJ | 1 |
| Astarie-Dequeker, C; Devynck, MA; Korichneva, I | 1 |
| Hollander, AM; Mento, PF; Wilkes, BM | 1 |
| Feller, DR; Miller, DD; Romstedt, KJ; Shin, Y | 1 |
| Kaiser, L; Lamb, VL; Rohn, WR; Schwartz, AJ | 1 |
| Cozzi, P; Ferrario, R; Giordani, A; Menichincheri, M; Pillan, A; Pinciroli, V; Rossi, A; Tamburin, M; Tonani, R; Volpi, D | 1 |
| Hanss, BG; Lewy, JE; Vari, RC | 1 |
| Liu, F; Orr, JA; Wu, JY | 1 |
| Campbell, AK; Leikauf, GD; Myatt, L; Rapoport, RM; Roszell, N; Williams, SP | 1 |
| Cudd, TA; Wood, CE | 1 |
| Bernheim, J; Cohen, E; Haviv, Y; Popovtzer, MM; Rubinger, D; Shiloni, E | 1 |
| Brezis, M; Greenfeld, Z; Rathaus, M | 1 |
| Collins, LJ; Kent, KC; McGrail, SH; Raychowdhury, MK; Ware, JA; Yukawa, M | 1 |
| Edberg, KE; Fish, W; Hellerqvist, C; Parker, RA; Sandberg, K; Sundell, H | 1 |
| Dorn, GW; Rapoport, RM; Williams, SP | 1 |
| Coffman, TM; Middleton, JP; Raymond, JR; Spurney, RF | 1 |
| Bertolino, F; Bessac, AM; John, GW; Jover, B; Maffre, M; Valentin, JP | 2 |
| Halushka, PV; Mais, DE; Okwu, AK | 1 |
| Dai, FX; Diederich, A; Diederich, D; Skopec, J | 1 |
| Brooks, RM; Heistad, DD; Kaul, S; Padgett, RC; Waack, BJ | 1 |
| Bhattacharya, J; Sadurski, R; Yang, GG | 1 |
| Doak, KW; Fingar, VH; Siegel, KA; Wieman, TJ | 1 |
| Le, SQ; Mombouli, JV; Vanhoutte, PM; Wasserstrum, N | 1 |
| Armstrong, RA; Humphrey, PP; Lumley, P | 1 |
| Huang, A; Koller, A; Sun, D | 2 |
| Borg, C; Knezevic, I; Le Breton, GC | 1 |
| Rapoport, RM | 1 |
| Eisert, W; Heckel, A; Müller, TH; Nickl, J; Soyka, R; Weisenberger, H | 1 |
| Davidge, ST; Hubel, CA; McLaughlin, MK | 3 |
| Hay, DW; Luttmann, MA; Muccitelli, RM; Torphy, TJ; Underwood, DC; Wasserman, MA | 1 |
| Badr, KF; Fukunaga, M; Makita, N; Morrow, JD; Roberts, LJ; Takahashi, K | 1 |
| Gao, Y; Vanhoutte, PM | 1 |
| Kan, WM; Tai, HH | 1 |
| Ambrosio, G; Chiariello, M; Golino, P; Gresele, P; Leproux, GB; Pascucci, I; Ragni, M; Russolillo, E | 1 |
| Cook, JA; Halushka, PV; Moore, JN; Simmons, TR | 1 |
| Cerletti, C; De Gaetano, G; Rotondo, S | 1 |
| Badr, KF; Fukunaga, M; Takahashi, K | 1 |
| Badr, K; Ebert, J; Frazer, M; Hardie, WD; Takahashi, K | 1 |
| Ambrosio, G; Chiariello, M; Condorelli, M; de Clerk, F; Focaccio, A; Golino, P; Pace, L; Ragni, M; Villari, B | 1 |
| Harris, DN; Misra, RN; Ogletree, ML; Schumacher, WA; Webb, ML | 1 |
| Coffman, TM; Onorato, JJ; Pisetsky, DS; Ruiz, P; Spurney, RF | 1 |
| Baron, DA; Heffner, JE; Zamora, CA | 1 |
| Banerjee, M; Kang, KH; Morrow, JD; Newman, JH; Roberts, LJ | 1 |
| Albers, FJ; Coffman, TM; Onorato, JJ; Spurney, RF | 1 |
| Haile, D; Matot, I; Neely, CF | 1 |
| Goldenberg, H; Harris, DN; Hedberg, A; Liu, EC; Misra, RN; Monshizadegan, H; Webb, ML | 1 |
| Appleyard, RF; Byrne, JG; Cohn, LH; Couper, GS; Laurence, RG; Sloane, JA; Sun, SC | 1 |
| Kryscio, RJ; Pettigrew, LC | 1 |
| Collins, LJ; Kent, KC; Raychowdhury, MK; Schwerin, FT; Ware, JA | 1 |
| Boineau, FG; Lewy, JE; Vari, RC | 1 |
| Burk, RM; Chen, J; Gac, TS; Gibson, LL; Krauss, AH; Lai, RK; Protzman, CE; Shan, T; Williams, LS; Woodward, DF | 1 |
| Druker, BJ; Handa, M; Ikeda, Y; Kato, T; Miyakawa, Y; Miyazaki, H; Oda, A; Ozaki, K; Shimosaka, A; Shirasawa, Y; Yabusaki, K | 1 |
| Rapoport, RM; Williams, SP | 1 |
| Ebina, S; Nakahata, N; Nakanishi, H; Yamamoto, K | 1 |
| Dieter, JP; Komiotis, D; Le Breton, GC; Lim, CT; Wencel-Drake, JD | 1 |
| Adam, LP; Franklin, MT; Mohler, ER | 1 |
| Chua, BH; Chua, CC; Hamdy, RC | 1 |
| Huang, A; Koller, A | 2 |
| Gao, XP; Jaffe, HA; Olopade, CO; Pakhlevaniants, S; Rubinstein, I; Suzuki, H | 1 |
| Heinisch, G; Holzer, W; Kunz, F; Langer, T; Lukavsky, P; Pechlaner, C; Weissenberger, H | 1 |
| Chiang, N; Kan, WM; Tai, HH | 1 |
| Baudry, N; Rasetti, C; Vicaut, E | 1 |
| Abbas, F; Burk, RM; Gac, TS; Gibson, LL; Krauss, AH; Marshall, K; Protzman, CE; Roof, MB; Senior, J; Williams, LS; Woodward, DF | 1 |
| Hidaka, T; Ishizuka, T; Kawakami, M; Matsuki, Y; Nakamura, H; Suzuki, K | 1 |
| Cicala, C; Cirino, G; Pinto, A; Sorrentino, L; Sorrentino, R | 1 |
| Carlisle, SJ; D'Angelo, DD; Dorn, GW; Lynch, KR; Terasawa, T | 1 |
| Hong, JL; Lee, LY | 1 |
| Nakahata, N; Ohizumi, Y; Ohkubo, S | 1 |
| Anand, R; Davies, S; Fernando, B; Harry, D; Marley, R; Moore, K | 1 |
| Bessac, AM; John, GW; Maffre, M; Valentin, JP | 1 |
| Epstein, M; Hayashi, K; Loutzenhiser, R | 1 |
| Bertolino, F; Fauré, P; John, GW; Valentin, JP; Vieu, S | 1 |
| Forster, H; Takenaka, T | 1 |
| Knight, DA; Stewart, GA; Thompson, PJ | 1 |
| Manchanda, SC; Seth, S; Seth, SD; Singh, J | 1 |
| Cofie, DQ; Dogan, S; Fugate, RD; Kem, DC; Turnbaugh, D; Zhang, M | 1 |
| Ellis, EF; Hoffman, SW; Moore, S | 1 |
| D'Angelo, DD; Davis, MG; Dorn, GW | 1 |
| Badr, KF; Fukunaga, M; Grygorczyk, R; Yura, T | 1 |
| Calzada, C; Lagarde, M; Vericel, E | 1 |
| Becker, BF; Gerlach, E; Möbert, J; Zahler, S | 1 |
| Ko, FN | 1 |
| Abbass, F; Burk, RM; Gac, TS; Gibson, LL; Krauss, AH; Marshall, K; Protzman, CE; Senior, J; Woodward, DF | 1 |
| Abbas, F; Amin, Z; Burk, RM; Krauss, AH; Marshall, K; Senior, J; Woodward, DF | 1 |
| Bertolino, F; Colpaert, FC; John, GW; Patoiseau, JF; Rieu, JP; Valentin, JP | 1 |
| Brisac, AM; Champeroux, P; Safar, M; Zerrouk, A | 1 |
| John, GW; Valentin, JP | 1 |
| Carretero, OA; Liu, YH; Pomposiello, S; Rhaleb, NE; Sevilla, M; Surakanti, M; Yang, XP | 1 |
| Meyer-Kirchrath, J; Muck, S; Schrör, K; Weber, AA | 1 |
| Devynck, MA; Kunes, J; Mazeaud, MM; Zicha, J | 1 |
| Kaley, G; Koller, A; Mizuno, R | 2 |
| Paul, RJ; Rapoport, RM; Tosun, M | 1 |
| Davis-Bruno, K; Halushka, PV; Schrör, K | 1 |
| Lane, K; Marshall, K; Senior, J | 1 |
| Auguet, M; Chabrier, PE; Zerrouk, A | 1 |
| Chung, JH; Chung, SM; Lee, JY; Lee, MY | 1 |
| Chiang, N; Tai, HH | 1 |
| Becker, BF; Möbert, J | 1 |
| Fitzgerald, D; Harriott, P; Moran, N; O'Luanaigh, N; Reilly, D; Stephens, G; Walker, B | 1 |
| Coffman, TM; Levenson, R; Mannon, RB; Spurney, RF | 1 |
| Connolly, C; Docherty, JR; McCormick, PA | 1 |
| Carretero, OA; Garvin, JL; Juncos, LA; Yu, H | 1 |
| García-Sacristán, A; Prieto, D; Simonsen, U | 1 |
| Kinsella, BT; Miggin, SM | 2 |
| Baena, AB; García-Cohen, EC; González, R; Marín, J; Rodríguez-Martínez, MA; Salaíces, M | 1 |
| FitzGerald, GA; Habib, A; Maclouf, J | 1 |
| Frölich, JC; Ikic, M; Raida, M; Tewes, KS; Tsikas, D | 1 |
| Lagarde, M; Lecomte, M; Michoud, E; Wiernsperger, N | 1 |
| Sekiguchi, F; Shimamura, K; Sunano, S; Tanaka, S; Watanabe, H | 1 |
| Laemmel, E; Stücker, O; Vicaut, E | 1 |
| Becker, BF; Conzen, PF; Heindl, B | 1 |
| Arendshorst, WJ; Brännström, K | 1 |
| Becker, KP; Garnovskaya, M; Gettys, T; Halushka, PV | 1 |
| Cruz, BV; Escalante, B | 1 |
| Bachschmid, M; Zou, MH | 1 |
| Damas, J; Delarge, J; Dogne, JM; Fontaine, J; Lacan, F; Lembege, M; Masereel, B; Nuhrich, A; Pochet, L | 1 |
| Grobuschek, T; Hammer-Kogler, S; Juan, H; Sametz, W; Wintersteiger, R | 1 |
| Crews, BC; Daniel, TO; Liu, H; Marnett, LJ; Morrow, JD | 1 |
| Fukami, MH; Holmsen, H; Idsøe, R; Selheim, F; Vassbotn, FS | 1 |
| Becker, K; Brodde, OE; Heinroth-Hoffmann, I; Osten, B; Pönicke, K | 1 |
| Brasch, F; Falk, S; Göggel, R; Heydasch, U; Müller, KM; Uhlig, S; Wendel, A | 1 |
| Bresnahan, BA; Lianos, EA | 1 |
| Chen, Y; Honn, KV; Lamberti, M; Li, L; Nie, D; Szekeres, K; Tang, K; Zacharek, A | 1 |
| Durieux, M; Erera, JS; Gear, AR; Honemann, CW; Lo, B; Polanowska-Grabowska, R | 1 |
| Nakahata, N; Ohizumi, Y; Takano, H | 1 |
| Mathy, MJ; Peters, SL; Pfaffendorf, M; van Zwieten, PA | 1 |
| Best, PJ; Holmes, DR; Lerman, A; Lerman, LO; Richardson, DM; Wilson, SH | 1 |
| Fischer, LG; Hollmann, MW; Horstman, DJ; Rich, GF | 1 |
| Jung, SM; Moroi, M | 1 |
| Awe, SO; Harris, LC; Ohia, SE; Opere, CA; Uketui, AJ | 1 |
| Hong, D; Ikezaki, H; Rubinstein, I; Suzuki, H | 1 |
| Davidge, ST; Stewart, KG; Zhang, Y | 1 |
| David, JL; de Leval, X; Delarge, J; Dogné, JM; Massereel, B; Neven, P; Rolin, S; Wauters, J | 1 |
| Inoue, S; Nishihara, M; Osumi, Y; Yokotani, K | 1 |
| Glaser, S; Hennerbichler, S; Juan, H; Sametz, W; Wintersteiger, R | 1 |
| Ammar, RF; Brooks, LA; Dellsperger, KC; Gutterman, DD | 1 |
| Campbell, AK; Rapoport, RM; Williams, SP | 1 |
| Kim, NN; Moreland, RB; Nehra, A; Parulkar, BG; Traish, A | 1 |
| Ashton, AW; Gao, Y; Tang, S; Ware, JA; Yokota, R | 1 |
| Armstead, WM | 1 |
| Martin, C; Uhlig, S; Wohlsen, A | 1 |
| Abe, Y; Chen, QH; Kosaka, H; Tian, RX; Yamamoto, A; Yoneyama, H; Zhang, L; Zhou, MS | 1 |
| Cartledge, JJ; Eardley, I; Joyce, AD; Minhas, S; Morrison, JF | 1 |
| Teoh, H; Trang, AJ; Ward, ME | 1 |
| Han, S; Purdy, RE; Sangha, DS | 1 |
| Blackman, SC; DeVries, GH; Le Breton, GC; Muja, N | 1 |
| Delarge, J; Dogné, JM; Masereel, B; Michaux, C; Rolin, S | 1 |
| Abeywardena, MY; Head, RJ | 1 |
| Awe, SO; Harris, LC; LeDay, AM; Ohia, SE; Opere, CA | 1 |
| Davenport, AP; Katugampola, SD | 1 |
| Gao, YJ; Lee, RM | 2 |
| Bagi, Z; Koller, A; Ungvari, Z | 1 |
| Asbóth, G; López, BA; Moore, F | 1 |
| Gresele, P; Mezzasoma, AM; Venditti, G; Vezza, R | 1 |
| Duarte, J; Galisteo, M; Jiménez, R; Zarzuelo, A | 1 |
| Hinek, A; Pace-Asciak, CR; Reynaud, D | 1 |
| Ballerio, R; Buccellati, C; Casagrande, C; Ciceri, P; Folco, G; Nicosia, S | 1 |
| Csiszar, A; Edwards, JG; Kaley, G; Kaminski, P; Koller, A; Ungvari, Z; Wolin, MS | 1 |
| Kita, Y; Shimizu, T; Uozumi, N; Wong, DA | 1 |
| Alonso, MJ; Briones, AM; Hernanz, R; Salaices, M; Tovar, S; Vila, E | 1 |
| Fang, Q; Kim, HJ; Kobayashi, T; Kohyama, T; Liu, X; Rennard, SI; Wen, FQ; Wyatt, TA | 1 |
| Abram, SR; Alexander, BT; Crell, A; Granger, JP; Llinás, MT; Seedek, M | 1 |
| Eilertsen, KE; Østerud, B | 1 |
| Higashi, M; Hiroki, J; Kunihiro, I; Matoba, T; Morikawa, K; Mukai, Y; Shimokawa, H; Takeshita, A; Talukder, HM | 1 |
| Hilbun, LR; Pallone, TL; Silldorff, EP | 1 |
| Fulton, CT; Stallone, JN | 1 |
| Cominacini, L; Fontana, L; Giagulli, C; Laudanna, C; Lechi, A; Minuz, P; Pasini, AF; Sala, A | 1 |
| Heinemann, A; Holzer, P; Peskar, BA; Shahbazian, A | 1 |
| Albadawi, H; Goldstein, I; Kim, NN; Min, KS; Moreland, RB; Nehra, A; Traish, AM; Watkins, MT | 1 |
| Blaie, S; Gallet, C; Habib, A; Lévy-Toledano, S | 1 |
| Huang, A; Huang, G; Li, D; Ruan, KH; So, SP; Wu, J | 1 |
| Fischer, MB; Gruber, R; Karreth, F; Schöfnagl, M; Watzek, G | 1 |
| Kudo, I; Nakayama, K; Saito, M; Tanabe, Y | 1 |
| Bonnardel-Phu, E; Hou, X; Laemmel, E; Seror, J; Vicaut, E | 1 |
| Ruan, KH; So, SP; Wu, J | 1 |
| Becker, WM; Branscheid, D; Lepp, U; Magnussen, H; Martin, C; Uhlig, S; Vollmer, E; Wohlsen, A | 1 |
| Lund, T; Østerud, B | 1 |
| Buikema, H; de Zeeuw, D; Gschwend, S; Henning, RH; Pinto, YM; van Gilst, WH | 1 |
| Ikezawa, S; Isogaya, M; Miyamoto, M; Ohno, M; Otake, A; Suzuki, M; Umemura, K; Yamada, N | 1 |
| Daray, FM; Minvielle, AI; Puppo, S; Rothlin, RP | 2 |
| Bosca, L; Cogolludo, A; Moreno, L; Perez-Vizcaino, F; Tamargo, J | 1 |
| Gilani, AU; Rasheed, H; Saeed, SA | 1 |
| Duka, A; Duka, I; Gavras, H; Gavras, I; Johns, C; Kintsurashvili, E | 1 |
| Demin, P; Halushka, PV; Pace-Asciak, CR; Qiao, N; Reynaud, D | 1 |
| Field, MC; Tippins, JR; Valentin, F | 1 |
| Böhm, E; Heinemann, A; Kollroser, M; McNamee, A; Pease, JE; Peskar, BA; Sandig, H; Shichijo, M; Sturm, GJ; Weiglhofer, I | 1 |
| Hilliard, GM; Paul, RJ; Thorne, GD | 1 |
| Ashton, AW; Cheng, Y; Helisch, A; Ware, JA | 1 |
| Alonso, MJ; Briones, AM; Hernanz, R; Salaices, M; Vila, E | 1 |
| Savci, V; Yalcin, M | 1 |
| Sharif, NA; Xu, SX | 1 |
| Bolla, M; Habib, A; Henrion, D; Levy, BI; Levy-Toledano, S; Loufrani, L; You, D | 1 |
| Ashton, AW; Ware, JA | 1 |
| Kulkarni, KH; LeDay, AM; Ohia, SE; Opere, CA | 1 |
| Bowen, IM; Chester, AH; Elliott, J; Marr, CM; Wheeler-Jones, CP | 1 |
| Kinsella, BT; O'Meara, SJ | 1 |
| Kostetskaia, E; Roche, AM; Smyth, EM; Wilson, SJ | 1 |
| Kingdon, E; Kumar, A; Norman, J | 1 |
| Clemens, MG; Karaa, A; Korneszczuk, K; Lin, T; Xu, H; Zhang, JX | 1 |
| Duckles, SP; Ghaffari, AA; Gonzales, RJ; Krause, DN | 1 |
| Oyekan, AO | 1 |
| Acosta Cazal, MC; Fortepiani, LA; Reckelhoff, JF; Santacruz, F | 1 |
| Bund, SJ; Healy, J; Hogan, M; O'Brien, S; O'Malley, KD | 1 |
| Cavun, S; Savci, V; Yalcin, M; Yilmaz, MS | 2 |
| Coviello, A; Jerez, S; Peral de Bruno, M | 1 |
| Hester, RL; Hodnett, BL; Naik, JS; Xiang, L | 2 |
| Bacon, KB; Okano, M; Shichijo, M; Sugimoto, H | 1 |
| Cyrus, T; Praticò, D; Tang, M; Vocun, L; Yao, Y | 1 |
| Gazi, L; Gyles, SL; Hunter, MG; Pettipher, R; Townsend, E; Wettey, FR; Xue, L | 1 |
| Allemann, R; Flammer, J; Haefliger, IO; Vysniauskiene, I | 1 |
| Betancourt, A; Freerksen, N; Garfield, R; Günter, HH; Maul, H; Orise, P; Saade, G; Sohn, C; Vedernikov, Y; Wentz, M | 1 |
| DiLizio, C; Kim, D; Manning, DR; Smyth, EM; Zhang, L | 1 |
| Pollock, DM; Williams, JM | 1 |
| Ak, F; Erturk, M; Yalcin, M | 1 |
| Miyosawa, K; Nakahata, N; Ohkubo, S; Sasaki, M | 1 |
| Bellahcène, A; Benoit, V; Castronovo, V; Dassesse, T; de Leval, X; Dogné, JM; Pirotte, B; Waltregny, D | 1 |
| Allona, A; Angulo, J; Cuevas, P; de Tejada, IS; Fernández, A; La Fuente, JM; Martín-Morales, A; Moncada, I | 1 |
| Carnish, E; Dowling, JK; Smyth, EM; Wilson, SJ; Zhao, L | 1 |
| Honma, S; Kurimoto, T; Nakahata, N; Ohkubo, S; Sato, Y; Shimura, T; Tanaka, T; Yoshida, M | 1 |
| Korstjens, IJ; Legerstee, N; Tangelder, GJ; Ter Wee, PM; van Rodijnen, WF | 1 |
| Allen, KE; Kharasch, ED; Sheffels, P; Totah, RA; Whittington, D | 1 |
| Boveris, D; Cesio, CE; Daray, FM; Errasti, AE; Luciani, LI; Nowak, W; Pelorosso, FG; Rothlin, RP; Tramontano, J | 1 |
| Bonaventura, D; de Oliveira, AM; Tirapelli, CR | 1 |
| Arendshorst, WJ; Iversen, BM; Vågnes, ØB | 1 |
| Iwashita, M; Nakahata, N; Saito, M; Takagaki, R; Yamaguchi, Y | 1 |
| Iwashita, M; Nakahata, N; Ohkubo, S; Oka, N; Saito, M | 1 |
| Cherdon, C; Dogne, JM; Hanson, J; Masereel, B; Pratico, D; Rolin, S; Vastersaegher, C | 1 |
| Gendron, ME; Thorin, E | 1 |
| Andoh, T; Kamimura, K; Kawai, S; Kuraishi, Y; Nakano, T; Nojima, H; Ohtsuka, E | 1 |
| Kawai, K; Kawai, S; Kawai, T; Kitagawa, T; Nagino, M; Watanabe, K; Yokoyama, Y | 1 |
| Aras-López, R; Balfagón, G; Blanco-Rivero, J; Ferrer, M; Martorell, A; Sagredo, A | 1 |
| Feletou, M; Jensen, BL; Leung, GP; Man, RY; Skott, O; Tang, EH; Vanhoutte, PM | 1 |
| Arezzini, B; Comporti, M; De Montis, MG; Gardi, C; Monaco, B; Vecchio, D | 1 |
| Che, M; Chen, Y; Guo, Y; Honn, KV; Nie, D; Qiao, Y; Tang, Y; Wang, MT; Yang, D; Zacharek, A | 1 |
| Higashino, H; Ishizuka, T | 1 |
| Abram, SR; Carter, C; Dearman, J; Hester, RL; Xiang, L | 1 |
| Boegehold, MA; Frisbee, JC; Samora, JB | 1 |
| Benavente-García, O; Castillo, J; Diaz-Ricart, M; Escolar, G; Lozano, ML; Martínez, C; Navarro-Núñez, L; Palomo, M; Rivera, J; Vicente, V | 1 |
| Holmsen, H; Vorland, M | 1 |
| Frisbee, JC; Goodwill, AG; James, ME | 1 |
| Agren, P; Blanco, CE; Cogolludo, AL; van der Sterren, S; Villamor, E | 1 |
| Garrido, A; Muñoz, Y; Valladares, L | 1 |
| Benndorf, RA; Böger, RH; Didié, M; Ergün, S; Gnann, A; Kom, G; Schwedhelm, E; Steenpass, A; Taheri, R | 1 |
| Brass, LF; Manning, DR; Zhang, L | 1 |
| Araujo, M; Welch, WJ | 1 |
| Bagi, Z; Erdei, N; Koller, A; Racz, A; Veresh, Z | 1 |
| Benavente-García, O; Castillo, J; Lozano, ML; Martínez, C; Navarro-Núñez, L; Rivera, J; Vicente, V | 1 |
| Priviero, FB; Teixeira, CE; Webb, RC; Zemse, SM | 1 |
| Grammas, P; Hutson, JC; Pandey, AK; Schiffer, RB; Stocco, DM; Wang, X; Yin, X | 1 |
| Han, JH; Lee, MY; Myung, SC | 1 |
| Destache, CJ; Ohia, SE; Opere, CA; Zhao, M | 1 |
| Aras-López, R; Balfagón, G; Ferrer, M; Martorell, A; Sagredo, A | 1 |
| Graham, DA; Rush, JW | 1 |
| Brotto, M; Gilbert, WJ; Kelly, JK; Kosloski, LM; Moore, DS; Orr, JA; Touchberry, CD; Wacker, MJ | 1 |
| Higashiyama, S; Nakahata, N; Obara, Y; Saito, M; Sasaki, M; Uchiyama, K | 1 |
| Daly, ME; Dawood, BB; Mumford, AD; Mundell, SJ; Murden, SL; Protty, MB; Spalton, JC; Watson, SP; Wheatley, M; Williams, MD | 1 |
| Khasawneh, FT; Murray, WJ; Ting, HJ | 1 |
| Matsushita, T; Miyamoto, M; Ohno, M; Ohtake, A; Yamada, N | 1 |
| Chen, GG; Hsin, MK; Huang, RY; Li, MY; Ma, LT; Mok, TS; Underwood, MJ; Warner, TD | 1 |
| Alioua, A; Kundu, P; Li, M; Lu, R; Marijic, J; Sanchez-Pastor, E; Stefani, E; Tanaka, Y; Toro, L; Wu, Y | 1 |
| Butcher, JT; Frisbee, JC; Goodwill, AG; Olfert, IM | 1 |
| Yalcin, M | 1 |
| Antonioli, L; Aydinoglu, F; Bernardini, N; Blandizzi, C; Colucci, R; Duranti, E; Fornai, M; Ippolito, C; Neves, MF; Rugani, I; Solini, A; Taddei, S; Virdis, A | 1 |
| Belvisi, MG; Birrell, MA; Buckley, J; Clarke, DL; Maher, SA; Nials, AT | 1 |
| Hester, RL; Lu, S; Sebai, M; Xiang, L | 1 |
| Beard, DA; Frisbee, JC; Wu, F | 1 |
| Llorens, S; Mendizábal, Y; Nava, E | 1 |
| Hausermann, L; St-Louis, J | 1 |
| Chakraborty, R; Chelikani, P; Dakshinamurti, S; Gleim, S; Hwa, J; Pydi, SP | 1 |
| Aschner, JL; Brown, N; Chen, JX; Ehinger, NJ; O'Mara, PW; Paria, BC; Poole, SD; Reese, J; Slaughter, JC | 1 |
| Abraham, NG; Bellner, L; Lamon, BD; Monu, SR; Nasjletti, A; Puri, N; Sodhi, K; Zhang, F; Zhang, Y | 1 |
| Brewer, J; Dechend, R; Ekholm, E; Gauster, M; Herse, F; Hoyer, J; Hubel, CA; Huppertz, B; Kaartokallio, T; Kacik, M; Laivuori, H; Lamarca, B; Lokki, AI; Luft, FC; Muller, DN; Novotny, S; Park, JK; Rothe, M; Ryan, MJ; Schunck, WH; Staff, AC; Sugulle, M; Verlohren, S; Wallukat, G | 1 |
| Campbell, WB; Gauthier, KM; Pfister, SL; Siangjong, L; Smyth, EM | 1 |
| Butcher, JT; Frisbee, JC; Goodwill, AG; Stanley, SC | 1 |
| Bachelot-Loza, C; Darnige, L; Fischer, AM; Gandrille, S; Gaussem, P; Jones, ML; Mumford, AD; Mundell, SJ; Nisar, S; Zinzindohoue, F | 1 |
| Debreczeni, B; Gara, E; Hamar, J; Koller, A; Marki, A; Matics, R; Racz, A; Veresh, Z | 1 |
| Chen, GG; Guo, HZ; Huang, RY; Huang, Y; Li, MY; Li, SS; Zeng, X; Zhang, X | 1 |
| Bhullar, RP; Chakraborty, R; Chelikani, P; Dakshinamurti, S; Hwa, J | 1 |
| Cogolludo, AL; Kessels, L; Perez-Vizcaino, F; van der Sterren, S; Villamor, E | 1 |
| Brooks, SD; Butcher, JT; Chantler, PD; Frisbee, JC; Stanley, SC; Wu, F | 1 |
| Choi, JK; Kim, HJ; Kim, SY; Lee, CH; Lim, KM; Nakahata, N; Park, MK | 1 |
| Antunes-Rodrigues, J; Carda, AP; Marchi, KC; Mecawi, AS; Padovan, CM; Rizzi, E; Tirapelli, CR | 1 |
| Brose, SA; Combs, CK; Ghatak, A; Golovko, MY; Puig, KL; Rebel, AA; Urquhart, SA | 1 |
| de Verdier, PJ; Guan, NN; Gustafsson, LE; Svennersten, K; Wiklund, NP | 1 |
| Adner, M; Al-Ameri, M; Bergman, P; Bood, J; Dahlén, SE; Delin, I; Manson, ML; Orre, AC; Säfholm, J | 1 |
| Barton, M; Fredette, NC; Meyer, MR; Prossnitz, ER | 1 |
| Duranti, E; Natali, A; Rossi, C; Solini, A; Taddei, S; Virdis, A | 1 |
| Leoncini, G; Signorello, MG | 1 |
| Chen, G; Liu, G; Liu, Q; Tao, B; Xiong, H; Yu, Y; Zhu, Q | 1 |
| Ha, KT; Jung, MH; Kim, BJ; Kim, HJ; So, I; Wie, J | 1 |
| Abrante, B; Diaz-Flores, F; Gonzalez-Paredes, FJ; Hernández Mesa, G; Hernández-Guerra, M; Marcelino Reyes, R; Morales Arraez, D; Quintero, E; Salido, E | 1 |
| Fu, N; Fu, Y; Shao, J; Shen, F; Xia, W; Yan, A; Yang, X; Zhang, T | 1 |
| Chakraborti, S; Chakraborti, T; Chowdhury, A; Sarkar, J | 1 |
| Du, Z; Sun, H; Sun, P; Zhang, W | 1 |
| Brun, BF; Campos-Toimil, M; Dias, AT; Gava, AL; Gil-Longo, J; Leal, MAS; Meyrelles, SS; Pereira, TMC; Porto, ML; Vasquez, EC | 1 |
| Cai, G; Fu, N; Fu, Y; Yan, A | 1 |
| Fu, H; Fu, J; Lu, H; Luo, Y; Ma, S; Wang, W; Xu, H; Zhang, Z; Zhu, X | 1 |
| Costa, KG; Fighera, MR; Freitas, ML; Furian, AF; Mello, FK; Moreira, MP; Neuberger, B; Oliveira, MS; Royes, LF; Souto, NS; Zorzi, VN | 1 |
| Aalkjaer, C; Chen, H; Simonsen, U | 1 |
Other Studies
503 other study(ies) available for hydrazine and sq 29548
| Article | Year |
|---|---|
Endothelial dysfunction of resistance arteries of spontaneously hypertensive rats.
Topics: Acetylcholine; Amitrole; Animals; Bridged Bicyclo Compounds, Heterocyclic; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Indomethacin; Male; Mesenteric Arteries; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred SHR; Renal Artery; Superoxides; Thromboxane A2; Vasodilation | 1992 |
Thromboxane A2 mimetic U46619 stimulates ciliary motility of rabbit tracheal epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cilia; Cyclic AMP; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Fatty Acids, Unsaturated; Hydrazines; Isoproterenol; Isoquinolines; Male; Movement; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Thromboxane A2; Trachea; Verapamil | 1992 |
Characterization of the thromboxane receptor mediating prostacyclin release from cultured endothelial cells.
Topics: Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Phenylacetates; Phosphatidylinositols; Prostaglandin Endoperoxides, Synthetic; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1992 |
Role of superoxide anion and endothelium in vasoconstrictor action of prostaglandin endoperoxide.
Topics: Acetylcholine; Animals; Anions; Bridged Bicyclo Compounds, Heterocyclic; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Prostaglandin Endoperoxides; Rabbits; Superoxide Dismutase; Superoxides; Thromboxane A2; Vasoconstriction; Vasodilation | 1992 |
Biological activity and metabolism of 20-hydroxyeicosatetraenoic acid in the human platelet.
Topics: Adult; Arachidonate 12-Lipoxygenase; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cyclic AMP; Fatty Acids, Unsaturated; Humans; Hydrazines; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Thromboxane A2 | 1992 |
Arachidonic acid- and acetylcholine-induced relaxations of rabbit aorta.
Topics: Acetylcholine; Animals; Aorta; Arachidonic Acid; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Cyclic GMP; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Male; Masoprocol; Metyrapone; Nitroarginine; Rabbits; Receptors, Thromboxane; Vasodilation | 1992 |
Characterization of thromboxane A2/prostaglandin H2 receptors and histamine H1 receptors in cultured guinea-pig tracheal smooth-muscle cells.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Fatty Acids, Unsaturated; Guinea Pigs; Histamine H1 Antagonists; Hydrazines; Male; Muscle, Smooth; Prostaglandin Endoperoxides, Synthetic; Prostaglandins H; Pyrilamine; Receptors, Histamine H1; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Trachea | 1992 |
Correction of ischaemic brain acidosis with SQ29,548/1-benzylimidazole.
Topics: Acidosis; Animals; Brain Ischemia; Bridged Bicyclo Compounds, Heterocyclic; Drug Therapy, Combination; Fatty Acids, Unsaturated; Hydrazines; Hydrogen-Ion Concentration; Imidazoles; Magnetic Resonance Imaging; Male; Prosencephalon; Rats; Rats, Wistar; Receptors, Thromboxane; Reperfusion Injury; Thromboxane A2; Thromboxane-A Synthase | 1992 |
Receptor binding properties of the new and specific thromboxane receptor antagonist Bay U 3405.
Topics: Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Kinetics; Membranes; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxanes | 1992 |
Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Fatty Acids, Unsaturated; Free Radicals; Glomerular Filtration Rate; Hematocrit; Hydrazines; Kidney Glomerulus; Male; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Renal Circulation; Thromboxane A2 | 1992 |
Characterization of binding of a specific antagonist, [3H]-SQ 29,548, to soluble thromboxane A2/prostaglandin H2 (TP) receptors in human platelet membranes.
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Humans; Hydrazines; Prostaglandin Antagonists; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Solubility; Thromboxane A2 | 1992 |
In vitro characterization of a novel TXA2/PGH2 receptor ligand (S-145) in platelets and vascular and airway smooth muscle.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; In Vitro Techniques; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Stereoisomerism; Trachea | 1992 |
Impairment of endothelium-dependent dilatation of the basilar artery during diabetes mellitus.
Topics: Acetylcholine; Animals; Basilar Artery; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Male; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Vasodilation | 1992 |
Characterization of thromboxane A2/prostaglandin H2 receptors in porcine coronary artery--the inhibitory effect of a novel dibenzoxepin derivative, KW-3635.
Topics: Animals; Benzimidazoles; Benzoxepins; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Fatty Acids, Unsaturated; Hydrazines; Membranes; Prostaglandins H; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Swine; Thromboxane A2 | 1992 |
Activation of leukocytes with complement C5a is associated with prostanoid-dependent constriction of large arteries in atherosclerotic monkeys in vivo.
Topics: Animals; Arteries; Arteriosclerosis; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Leukocytes; Lipids; Macaca fascicularis; Male; Platelet Activating Factor; Prostaglandins; Thromboxane A2; Triazoles; Vasoconstriction | 1992 |
Differences in activities of thromboxane A2 receptor antagonists in smooth muscle cells.
Topics: Animals; Benzimidazoles; Benzoxepins; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Fatty Acids, Unsaturated; Hydrazines; Male; Muscle, Smooth, Vascular; Phenylacetates; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Wistar; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; Thromboxane A2 | 1992 |
Effects of KW-3635, a novel dibenzoxepin derivative of a selective thromboxane A2 antagonist, on human, guinea pig and rat platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzimidazoles; Benzoxepins; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; In Vitro Techniques; Kinetics; Prostaglandin Endoperoxides, Synthetic; Radioligand Assay; Rats; Receptors, Thromboxane; Species Specificity; Thromboxane A2; Tritium; Vasoconstrictor Agents | 1992 |
Angiotensin II influences the renal hemodynamic response to blockade of thromboxane A2 and prostaglandin H2 receptors.
Topics: Angiotensin II; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Kidney; Male; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Renal Circulation; Thromboxane A2; Vascular Resistance | 1992 |
Actions of SQ 29,548 on contractile responses and arachidonic acid metabolism of intrapulmonary arteries, in vitro.
Topics: Animals; Arachidonic Acid; Arteries; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Lung; Microsomes; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Pulmonary Veins; Thromboxane A2; Vasoconstriction | 1992 |
Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Antagonism; Fatty Acids, Unsaturated; Heptanoic Acids; Hydrazines; Indoles; Male; Muscle, Smooth, Vascular; Phenylacetates; Prostaglandin Endoperoxides, Synthetic; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Species Specificity; Sulfonamides; Thromboxane A2 | 1992 |
Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes.
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cholic Acids; Detergents; Digitonin; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Humans; Hydrazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1992 |
Pharmacological characterization of potent, long-acting thromboxane receptor antagonists, SQ 33,261 and SQ 33,552.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Pressure; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; Hydrazones; Male; Mice; Muscle Contraction; Muscle, Smooth; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Radioimmunoassay; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents | 1992 |
Characterization of thromboxane receptor blocking effects of SQ 29548 in the feline pulmonary vascular bed.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cats; Fatty Acids, Unsaturated; Female; Hydrazines; Kinetics; Male; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Receptors, Prostaglandin; Receptors, Thromboxane; Vasoconstriction | 1992 |
Role of prostaglandin H2-thromboxane A2 in responses of cerebral arterioles during chronic hypertension.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arterioles; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chronic Disease; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; Male; Nitroglycerin; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thromboxane A2; Vasodilator Agents | 1992 |
Mechanism of inositol 1,4,5-trisphosphate-induced aggregation in saponin-permeabilized platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane Permeability; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Indomethacin; Inositol 1,4,5-Trisphosphate; Platelet Aggregation; Platelet Aggregation Inhibitors; Saponins; Thromboxane A2 | 1992 |
In vitro responses of ovine intrapulmonary arteries and veins to endothelin-1.
Topics: Aging; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Endothelins; Fatty Acids, Unsaturated; Fetus; Hydrazines; Indomethacin; Pulmonary Artery; Pulmonary Veins; Sheep; Thromboxane A2; Vasoconstriction | 1992 |
Thromboxane mediates diapedesis after ischemia by activation of neutrophil adhesion receptors interacting with basally expressed intercellular adhesion molecule-1.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; CD18 Antigens; Cell Adhesion Molecules; Dactinomycin; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Intercellular Adhesion Molecule-1; Ischemia; Male; Methacrylates; Muscles; Neutrophils; Rabbits; Receptors, Leukocyte-Adhesion; Reference Values; Regional Blood Flow; Reperfusion; Skin; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1991 |
Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s.
Topics: Adenylate Cyclase Toxin; Alprostadil; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cyclic AMP; Cyclic GMP; Dinoprostone; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Iloprost; Leukemia, Megakaryoblastic, Acute; Pertussis Toxin; Prostaglandin D2; Prostaglandins F; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-injured canine coronary arteries.
Topics: Adenosine Diphosphate; Animals; Apyrase; Bridged Bicyclo Compounds, Heterocyclic; Clopidogrel; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Thromboxane A2; Ticlopidine | 1992 |
Purification of the human blood platelet thromboxane A2/prostaglandin H2 receptor protein.
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Affinity; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Fatty Acids, Unsaturated; Humans; Hydrazines; Membrane Proteins; Molecular Weight; Platelet Activation; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1992 |
Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular System; Dinoprost; Fatty Acids, Unsaturated; Hydrazines; Prostaglandin D2; Pulmonary Circulation; Receptors, Prostaglandin; Receptors, Thromboxane; Respiratory Mechanics; Sheep; Thromboxane A2; Thromboxanes; Vasoconstriction | 1991 |
Mechanism of impaired responses of cerebral arterioles during diabetes mellitus.
Topics: Animals; Arginine; Arterioles; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diabetes Mellitus, Experimental; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Nitric Oxide; omega-N-Methylarginine; Prostaglandins H; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxanes; Vasoconstriction; Vasodilation | 1991 |
Characterization of thromboxane A2/prostaglandin H2 receptors of various tissues using a new radioiodinated thromboxane A2/prostaglandin H2 mimetic, I-BOP.
Topics: Animals; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; Lung; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1991 |
Heterogeneity of prostaglandin H2/thromboxane A2 receptors: distinct subtypes mediate vascular smooth muscle contraction and platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding, Competitive; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Fatty Acids, Unsaturated; Heptanoic Acids; Hydrazines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1991 |
Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bromosuccinimide; Carbazoles; Cell Membrane; Diethyl Pyrocarbonate; Fatty Acids, Unsaturated; Histidine; Humans; Hydrazines; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Ligands; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Protein Binding; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Solubility; Thromboxane A2 | 1991 |
Pharmacologic antagonism of thromboxane A2 receptors by trimetoquinol analogs in vitro and in vivo.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Death, Sudden; Disease Models, Animal; Fatty Acids, Unsaturated; Humans; Hydrazines; Male; Mice; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Stereoisomerism; Thromboxane A2; Tretoquinol; Tritium | 1991 |
Adenosine and ATP produce vasoconstriction in the feline pulmonary vascular bed by different mechanisms.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cats; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Lung; Meclofenamic Acid; Phenylisopropyladenosine; Purinergic Antagonists; Receptors, Prostaglandin; Receptors, Purinergic; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction; Vasodilator Agents; Xanthines | 1991 |
Mesangial cell immune injury: effects of thromboxane receptor antagonism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antilymphocyte Serum; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Eicosanoids; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Glomerular Mesangium; Hydrazines; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1991 |
Platelet endoperoxide/thromboxane A2 (PGH2/TXA2) receptors in patients with myeloproliferative disorders.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Aged; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; In Vitro Techniques; Kinetics; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane | 1991 |
Influence of SQ 29,548 on vasoconstrictor responses in the hindquarters vascular bed of the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cats; Fatty Acids, Unsaturated; Hydrazines; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Vascular Resistance; Vasoconstriction | 1991 |
Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Cats; Dinoprost; Endothelins; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin; Thromboxane A2; Vasoconstriction | 1991 |
Thromboxane mediates renal hemodynamic response to infused angiotensin II.
Topics: Angiotensin II; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Imidazoles; Male; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Renal Circulation; Thromboxane A2; Thromboxane-A Synthase; Vascular Resistance | 1991 |
Regulation of the rat aortic smooth muscle cell thromboxane A2 receptor.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Culture Techniques; Fatty Acids, Unsaturated; Hydrazines; Kinetics; Muscle, Smooth, Vascular; Rats; Receptors, Thromboxane | 1991 |
Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction.
Topics: Acetylcholine; Analysis of Variance; Angiotensin II; Animals; Aorta; Aortic Coarctation; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelins; Endothelium; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Phenylephrine; Prostaglandin Endoperoxides, Synthetic; Pyridines; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasoconstriction | 1991 |
Prostanoid antagonists inhibit the response of the microcirculation to "early" photodynamic therapy.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Male; Microcirculation; Muscles; Photochemotherapy; Prostaglandin Antagonists; Rats; Rats, Inbred Strains; Thromboxane A2 | 1991 |
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dogs; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Ketoconazole; Kinetics; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Phosphorylcholine; Proadifen; Renal Artery; Triazoles | 1991 |
Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2 antagonists. Semicarbazone omega-chains.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Humans; Hydrazines; Magnetic Resonance Spectroscopy; Mice; Semicarbazones; Stereoisomerism; Thromboxane A2 | 1991 |
ONO NT-126 is a potent and selective thromboxane A2 antagonist in human astrocytoma cells.
Topics: Astrocytoma; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Humans; Hydrazines; Hydrolysis; Inositol Phosphates; Phosphatidylinositols; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Tumor Cells, Cultured | 1990 |
Role of prostanoids in renin-dependent and renin-independent hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Male; Prostaglandins; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Prostaglandin; Renin; Thromboxane A2; Thromboxane B2 | 1991 |
Endogenous vasoconstrictor prostanoids: role in serotonin and vasopressin-induced coronary vasoconstriction.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Drug Interactions; Fatty Acids, Unsaturated; Hydrazines; Male; Prostaglandins; Prostanoic Acids; Rats; Rats, Inbred Strains; Serotonin Antagonists; Thromboxane A2; Vasoconstriction; Vasopressins | 1991 |
Mechanism of vascular actions of prostacyclin in the rat isolated perfused mesenteric arteries.
Topics: Adenylyl Cyclases; Animals; Arginine Vasopressin; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Male; Mesenteric Arteries; Norepinephrine; Ouabain; Perfusion; Potassium; Potassium Channels; Rats; Superoxide Dismutase | 1990 |
Role of thromboxane A2 in the cardiovascular response to intracoronary C5a.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular System; Complement C5a; Coronary Vessels; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; Injections; Male; Swine; Tachyphylaxis; Thromboxane A2; Thromboxanes | 1990 |
Mediation of bradykinin-induced contraction in canine veins via thromboxane/prostaglandin endoperoxide receptor activation.
Topics: Animals; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Pyridines; Receptors, Prostaglandin; Sulfonamides; Thromboxane-A Synthase; Thromboxanes; Veins | 1990 |
Influence of inhibitors of eicosanoid metabolism on proliferation of rat hepatoma cells and on tumor-host interaction.
Topics: Acrylates; Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Eicosanoids; Fatty Acids, Unsaturated; Flurbiprofen; Hydrazines; Liver Neoplasms, Experimental; Male; Methacrylates; Rats; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured | 1990 |
Cyclooxygenase inhibition prevents PMA-induced increases in lung vascular permeability.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Body Fluids; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Methacrylates; Prostaglandins; Pulmonary Circulation; Rabbits; Tetradecanoylphorbol Acetate; Thromboxane A2; Thromboxane-A Synthase; Vascular Resistance | 1990 |
Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Epidermal Growth Factor; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Ibuprofen; Ketoconazole; Kidney; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Regional Blood Flow | 1990 |
Role of thromboxane A2/prostaglandin H2 receptor in the vasoconstrictor response of rat aorta to endothelin.
Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Endothelins; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Peptides; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1990 |
The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Edetic Acid; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; In Vitro Techniques; Indomethacin; Kinetics; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Structure-Activity Relationship; Thrombin; Thromboxane A2; Thromboxanes | 1990 |
Contrasting effect of thromboxane synthase inhibitors and a thromboxane receptor antagonist on the development of angiotensin II-salt-induced hypertension in rats.
Topics: Angiotensin II; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; Male; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Sodium Chloride; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Effects of thromboxane A2 on thoracic aorta of young and old rats: use of selective thromboxane receptor antagonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aging; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred F344; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Tretoquinol | 1990 |
Involvement of platelet activating factor and thromboxane A2 in the renal response to unilateral ureteral obstruction.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Fatty Acids, Unsaturated; Female; Hydrazines; Platelet Activating Factor; Pressure; Prostaglandin Endoperoxides, Synthetic; Quinolinium Compounds; Receptors, Prostaglandin; Receptors, Thromboxane; Renal Circulation; Thromboxane A2; Ureter; Ureteral Obstruction; Vascular Resistance; Vasoconstriction | 1990 |
The effect of thromboxane receptor blockade versus thromboxane synthase inhibition on canine arterial graft patency.
Topics: Animals; Aspirin; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Dipyridamole; Dogs; Fatty Acids, Unsaturated; Graft Occlusion, Vascular; Hydrazines; Male; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Vascular Patency | 1990 |
Combined thromboxane A2 synthetase inhibition and receptor blockade are effective in preventing spontaneous and epinephrine-induced canine coronary cyclic flow variations.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Dogs; Epinephrine; Epoprostenol; Ergolines; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; Male; Pentanoic Acids; Pyridines; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin Antagonists; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activator. Effects of simultaneous inhibition of thromboxane A2 synthase and blockade of thromboxane A2/prostaglandin H2 receptors in a canine
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Coronary Thrombosis; Cricetinae; Dogs; Fatty Acids, Unsaturated; Fibrinolysis; Hydrazines; Imidazoles; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Thromboxane-A Synthase; Tissue Plasminogen Activator | 1990 |
Thromboxane A2/prostaglandin H2 receptor antagonists.
Topics: Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Kinetics; Molecular Structure; Phenylacetates; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Structure-Activity Relationship; Sulfonamides; Thromboxane A2 | 1990 |
Bradykinin-induced vasoconstriction of rat mesenteric arteries precontracted with noradrenaline.
Topics: Animals; Aspirin; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Eicosanoids; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; In Vitro Techniques; Indomethacin; Meclofenamic Acid; Mesenteric Arteries; Norepinephrine; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction | 1990 |
[Characterization of thromboxane A2 receptors in rat kidney].
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Kidney; Kidney Diseases; Male; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Subcellular Fractions; Thromboxane A2 | 1990 |
Renal function in rats with angiotensin II-salt-induced hypertension: effect of thromboxane synthesis inhibition and receptor blockade.
Topics: Angiotensin II; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; Kidney; Male; Rats; Rats, Inbred Strains; Sodium, Dietary; Thromboxane A2; Thromboxane-A Synthase; Vascular Resistance | 1990 |
Leukocyte and platelet-derived factors augment canine coronary constriction to serotonin.
Topics: Acetylcholine; Aminoquinolines; Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Cyclic GMP; Dogs; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; In Vitro Techniques; Leukocytes; Male; Nitroprusside; Serotonin; Thromboxane A2; Vasoconstriction; Vasodilation | 1990 |
Thromboxane A2-mimetics are potent microvascular permeability factors in the conjunctiva.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Conjunctiva; Conjunctivitis; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; Male; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1990 |
Angiotensin and thromboxane in the enhanced renal adrenergic nerve sensitivity of acute renal failure.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Blood Flow Velocity; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Kidney; Norepinephrine; Rats; Rats, Inbred Strains; Renal Circulation; Saralasin; Sympathetic Nervous System; Thromboxane A2 | 1990 |
Prostanoids and hypothermic renal preservation injury.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Dogs; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Kidney; Organ Preservation; Prostaglandins; Pyridines; Renal Circulation; Reperfusion Injury; Thromboxanes | 1990 |
Effect of thromboxane A2/endoperoxide antagonist SQ29548 on the contractile response to acetylcholine in newborn piglet cerebral arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Animals, Newborn; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Arteries; Dinoprost; Drug Synergism; Fatty Acids, Unsaturated; Hydrazines; Norepinephrine; Pia Mater; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Vasoconstriction | 1990 |
Feedback responses during sequential inhibition of angiotensin and thromboxane.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Feedback; Hydrazines; Male; Pilot Projects; Rats; Rats, Inbred Strains; Saralasin; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Phorbol ester-induced expression of the common, low-affinity binding site for primary prostanoids in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alprostadil; Animals; Aorta, Thoracic; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dinoprost; Fatty Acids, Unsaturated; Hydrazines; Isoquinolines; Kinetics; Male; Muscle, Smooth, Vascular; Piperazines; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Tetradecanoylphorbol Acetate | 1990 |
Primed stimulation of isolated perfused rabbit lung by endotoxin and platelet activating factor induces enhanced production of thromboxane and lung injury.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Drug Synergism; Endotoxins; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; In Vitro Techniques; Indomethacin; Lipopolysaccharides; Lung; Perfusion; Platelet Activating Factor; Pulmonary Edema; Rabbits; Thromboxanes; Tumor Necrosis Factor-alpha | 1990 |
Thromboxane mediation of the pressor response to infused angiotensin II.
Topics: Angiotensin II; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; Infusions, Intravenous; Male; Phenoxybenzamine; Phenylephrine; Pressoreceptors; Rats; Rats, Inbred Strains; Saralasin; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Urine | 1990 |
Influence of SQ 29,548 on vasoconstrictor responses in the mesenteric vascular bed of the cat.
Topics: Angiotensin II; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cats; Dinoprost; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Norepinephrine; Perfusion; Prostaglandin Endoperoxides, Synthetic; Splanchnic Circulation; Thromboxane B2; Time Factors; Vasoconstriction; Vasodilation | 1990 |
Thromboxane plays a role in postprandial jejunal oxygen uptake and capillary exchange.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; Dogs; Eating; Fatty Acids, Unsaturated; Female; Hydrazines; Jejunum; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Oxygen; Oxygen Consumption; Regional Blood Flow; Thromboxane A2 | 1990 |
Mechanism of the pressor effect of the calcium agonist, BAY k 8644, in the intact rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetophenones; Animals; Arginine Vasopressin; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Catecholamines; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Male; Nifedipine; Nisoldipine; Nitrendipine; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Saralasin; Tetrazoles | 1986 |
Cardioprotective actions of specific thromboxane receptor antagonist in acute myocardial ischemia.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cats; Creatine Kinase; Fatty Acids, Unsaturated; Heart; Heart Rate; Hydrazines; Isoenzymes; Male; Myocardial Infarction; Myocardium; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane | 1987 |
Blockade of thromboxane responses in the airway of the cat by SQ 29,548.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cats; Cytochrome P-450 Enzyme System; Dinoprost; Dose-Response Relationship, Drug; Epoprostenol; Fatty Acids, Unsaturated; Female; Hydrazines; Intramolecular Oxidoreductases; Isomerases; Male; Meclofenamic Acid; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-E Synthases; Prostaglandins D; Prostaglandins F; Serotonin; Thromboxanes | 1987 |
Effect of the thromboxane receptor antagonist SQ 29,548 on myocardial infarct size in dogs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Myocardial Infarction; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Regional Blood Flow; Thromboxane A2 | 1988 |
The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Drug Synergism; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Iloprost; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandins, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides | 1988 |
Desensitisation of human platelets against stimulation by thromboxane mimics--reduction in receptor capacity and loss of functional response.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Iloprost; Kinetics; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Receptors, Prostaglandin; Thromboxane A2 | 1988 |
Thromboxane mimetics enhance adrenergic neurotransmission in the rabbit-isolated portal vein.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Electric Stimulation; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Prostaglandin Endoperoxides, Synthetic; Rabbits; Sympathetic Nervous System; Synaptic Transmission; Thromboxane A2 | 1989 |
Simultaneous administration of thromboxane A2- and serotonin S2-receptor antagonists markedly enhances thrombolysis and prevents or delays reocclusion after tissue-type plasminogen activator in a canine model of coronary thrombosis.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Coronary Disease; Coronary Thrombosis; Dogs; Drug Therapy, Combination; Ergolines; Fatty Acids, Unsaturated; Hydrazines; Myocardial Reperfusion; Platelet Aggregation; Recombinant Proteins; Recurrence; Serotonin; Serotonin Antagonists; Thromboxane A2; Time Factors; Tissue Plasminogen Activator | 1989 |
Possible involvement of cytoskeleton in collagen-stimulated activation of phospholipases in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Collagen; Cytochalasin B; Cytoskeleton; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Indomethacin; Inositol Phosphates; Kinetics; Phospholipases; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1989 |
Do inhibitors of lipoxygenase and cyclooxygenase block neonatal hypoxic pulmonary vasoconstriction?
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Animals, Newborn; Arachidonate Lipoxygenases; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hypoxia; Phenylbutyrates; Pulmonary Circulation; Pyrazoles; Sheep; SRS-A | 1989 |
Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites.
Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Male; Mass Spectrometry; Microsomes; Muscle Contraction; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Seminal Vesicles; Sheep; Vasoconstrictor Agents | 1989 |
Modulation of renin by thromboxane: studies with thromboxane synthase inhibitor, receptor antagonists, and mimetic.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Analysis of Variance; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Dibenzothiepins; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Imidazoles; Indomethacin; Kidney; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Reference Values; Renin; Thromboxane-A Synthase; Thromboxanes | 1989 |
Modulation of vascular tone by neutrophils: dependence on endothelial integrity.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Captopril; Endothelium, Vascular; Epinephrine; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Indomethacin; Muscle Tonus; Muscle, Smooth, Vascular; Neutrophils; Rats; Rats, Inbred Strains; Thromboxane A2 | 1989 |
Serotonin S2 and thromboxane A2-prostaglandin H2 receptor blockade provide protection against epinephrine-induced cyclic flow variations in severely narrowed canine coronary arteries.
Topics: Animals; Blood Flow Velocity; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Dogs; Epinephrine; Ergolines; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Male; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin Antagonists; Yohimbine | 1989 |
Evidence for functional thromboxane A2-prostaglandin H2 receptors in human placenta.
Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; In Vitro Techniques; Kinetics; Placenta; Pregnancy; Prostaglandin Endoperoxides; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1989 |
Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Kidney; Male; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Prostaglandins H; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction | 1989 |
Comparison of vascular and platelet thromboxane A2/prostaglandin H2 receptors in the pig.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Platelets; Blood Vessels; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Ligands; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Swine; Thromboxane A2 | 1989 |
Characterization of glomerular thromboxane receptor sites in the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Kidney Glomerulus; Kinetics; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Renal Circulation; Thromboxane B2 | 1989 |
Role of TXA2 in the pathogenesis of severe angiotensin II-salt hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; In Vitro Techniques; Kidney; Kidney Cortex; Muscle, Smooth, Vascular; Rats; Reference Values; Sodium, Dietary; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1989 |
Inhibition of thromboxane responses in the airway of the cat by SQ29,548 and OKY 1581.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acrylates; Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Cats; Dinoprost; Fatty Acids, Unsaturated; Hydrazines; Lung; Methacrylates; Prostaglandin Endoperoxides, Synthetic; Respiratory Function Tests; Thromboxane A2; Thromboxane-A Synthase | 1989 |
Human platelets modulate edema formation in isolated rabbit lungs.
Topics: Animals; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Dehydroepiandrosterone; Fatty Acids, Unsaturated; Female; Glucosephosphate Dehydrogenase; Humans; Hydrazines; Male; Papaverine; Perfusion; Pulmonary Edema; Pulmonary Wedge Pressure; Purines; Rabbits; Thromboxane B2; Xanthine Oxidase | 1989 |
Involvement of prostanoids in the pulmonary pressor effect of histamine.
Topics: Animals; Arachidonic Acids; Biological Assay; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Fatty Acids, Unsaturated; Guinea Pigs; Histamine; Hydrazines; Imidazoles; In Vitro Techniques; Indomethacin; Lung; Pulmonary Artery; Rabbits; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane-A Synthase | 1989 |
Thromboxane mediates the ischemia-induced neutrophil oxidative burst.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Flow Cytometry; Hindlimb; Hydrazines; Hydrogen Peroxide; Ischemia; Male; Methacrylates; Neutrophils; Oxidation-Reduction; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Reperfusion; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1989 |
Biochemical characterization and comparison of rat thromboxane A2/prostaglandin H2 receptors in platelets and cultured aortic smooth muscle cells.
Topics: Animals; Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hydrazines; Kinetics; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1989 |
Permissive role of prostanoids in acetylcholine-induced cerebral vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebrovascular Circulation; Dinoprost; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Swine; Vasoconstriction | 1989 |
Antagonistic actions of S-145 on vascular and platelet thromboxane A2 receptors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Swine; Thromboxane A2 | 1989 |
Reduced myocardial neutrophil accumulation and infarct size following thromboxane synthetase inhibitor or receptor antagonist.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Chemotaxis, Leukocyte; Creatine Kinase; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Male; Myocardial Infarction; Myocardium; Neutrophils; Peroxidase; Platelet Aggregation; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1989 |
Thromboxane receptor agonists enhance adrenergic neurotransmission in rabbit isolated mesenteric arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Mesenteric Arteries; Norepinephrine; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Synaptic Transmission; Thromboxane A2; Thromboxanes; Vasoconstriction | 1989 |
Thromboxane A2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein.
Topics: Adenosine Diphosphate; Astrocytoma; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Enzyme Activation; Fatty Acids, Unsaturated; GTP-Binding Proteins; Hydrazines; Inositol Phosphates; Pertussis Toxin; Phosphatidylinositols; Receptors, Prostaglandin; Receptors, Thromboxane; Ribose; Thromboxane A2; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1989 |
Arachidonic acid metabolites modulate rat hypothalamic corticotropin-releasing hormone secretion in vitro.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Corticotropin-Releasing Hormone; Culture Techniques; Dexamethasone; Dinoprost; Dinoprostone; Eicosanoids; Fatty Acids, Unsaturated; Hydrazines; Hypothalamus; Indomethacin; L-Lactate Dehydrogenase; Leukotriene B4; Male; Prostaglandin Antagonists; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Serotonin; SRS-A; Thromboxane A2; Thromboxane B2 | 1989 |
Influence of thromboxane A2 receptor antagonism on pulmonary vasoconstrictor responses.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Animals, Newborn; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Hypoxia; Lung; Male; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Vasoconstriction | 1989 |
Importance of prostaglandins in hypertension during reduced uteroplacental perfusion pressure.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Fatty Acids, Unsaturated; Female; Hydrazines; Hypertension; Ischemia; Meclofenamic Acid; ortho-Aminobenzoates; Placenta; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy, Animal; Prostaglandins; Reperfusion; Thromboxane A2; Uterus | 1989 |
Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury.
Topics: Animals; Antithrombin III; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hemodynamics; Heparin; Hydrazines; Ketanserin; Male; Peptide Hydrolases; Pipecolic Acids; Platelet Aggregation; Sulfonamides; Thrombin | 1989 |
Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland.
Topics: Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cats; Fatty Acids, Unsaturated; Glucosamine; Glycoconjugates; Hydrazines; In Vitro Techniques; Indomethacin; Kinetics; Methysergide; Mucous Membrane; Phospholipid Ethers; Platelet Activating Factor; Radioisotope Dilution Technique; Thromboxane A2; Trachea; Tritium | 1989 |
Intravenous lipids in newborn lungs: thromboxane-mediated effects.
Topics: Animals; Animals, Newborn; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fat Emulsions, Intravenous; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Hypertension, Pulmonary; Lung; Oxygen Consumption; Pulmonary Artery; Swine; Thromboxane B2; Thromboxanes; Vascular Resistance; Vasodilation | 1989 |
Thromboxane A2 mediates increased pulmonary microvascular permeability following limb ischemia.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Drug Combinations; Fatty Acids, Unsaturated; Female; Hydrazines; Ibuprofen; Ischemia; Leg; Lung; Methacrylates; Microcirculation; Pulmonary Artery; Reperfusion; Sheep; Thromboxane A2; Thromboxane-A Synthase | 1989 |
Inhibition of pulmonary thromboxane A2 synthase activity and airway responses by CGS 13080.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Cats; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Imidazoles; Lung; Male; Meclofenamic Acid; Microsomes; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyridines; Thromboxane A2; Thromboxane-A Synthase | 1989 |
[Effect of a new thromboxane A2 antagonist, S-145, on platelet aggregation].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Administration, Oral; Adult; Animals; Arachidonic Acids; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Collagen; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thromboxane A2 | 1989 |
Analysis of bronchoconstrictor responses to platelet-activating factor in the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Cats; Fatty Acids, Unsaturated; Female; Hydrazines; Lung Compliance; Male; Meclofenamic Acid; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1989 |
The role of lipid mediators in hypoxic pulmonary vasoconstriction in newborns.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetophenones; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hypoxia; Lipids; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; SRS-A; Swine; Tetrazoles; Thromboxane A2; Vasoconstriction | 1989 |
Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF.
Topics: Amiloride; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydrazines; Indomethacin; Platelet Activating Factor; Platelet Aggregation; Protons; Serotonin; Sodium; Thromboxane A2; Thromboxane B2 | 1987 |
Thromboxane effects on canine trachealis neuromuscular function.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Fatty Acids, Unsaturated; Female; Hydrazines; In Vitro Techniques; Leukotriene B4; Male; Muscle, Smooth; Neuromuscular Junction; Platelet Activating Factor; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; SRS-A; Thromboxane A2; Trachea | 1988 |
Role of arachidonate metabolites in C5a-induced bronchoconstriction.
Topics: Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Complement C5; Complement C5a; Dinoprost; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; Injections, Intravenous; Leukotriene B4; Lung; Prostaglandin D2; Prostaglandins D; Prostaglandins F; Thromboxane B2; Thromboxane-A Synthase | 1988 |
Polymyxin B increases TXA2/PGH2 agonist and antagonist affinities in human platelet membranes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Isoquinolines; Piperazines; Polymyxin B; Polymyxins; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins H; Protein Kinase Inhibitors; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1988 |
Circulatory effects of PAF-acether in newborn piglets.
Topics: 6-Ketoprostaglandin F1 alpha; Acetophenones; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Indomethacin; Platelet Activating Factor; Pulmonary Circulation; Pulmonary Wedge Pressure; Swine; Tetrazoles; Thromboxane B2; Vascular Resistance | 1989 |
Role of thromboxane A2 in the control of myocardial O2 supply/consumption balance and severity of ischemia during pacing-induced ischemia.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Electrocardiography; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Male; Myocardium; Oxygen Consumption; Thromboxane A2; Time Factors | 1989 |
Antiaggregatory effects of thromboxane receptor antagonists in vivo.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Fatty Acids, Unsaturated; Fibrinolytic Agents; Hydrazines; Imidazoles; Kinetics; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane-A Synthase; Thromboxanes | 1985 |
Antagonism of thromboxane actions in the isolated perfused rat heart.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine Vasopressin; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Fatty Acids, Unsaturated; Hydrazines; Male; Pressure; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; SRS-A; Thromboxane A2; Vascular Resistance; Vasoconstriction | 1986 |
Prostaglandin regulation of colonic blood flow in rabbit colitis.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Output; Colitis; Colon; Dinitrochlorobenzene; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; Immune Complex Diseases; Male; Prostaglandins; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Regional Blood Flow; Thromboxane-A Synthase | 1987 |
Effect of the thromboxane A2-receptor antagonists, SQ 29,548 and SQ 28,668, on the pulmonary hypertensive response to endotoxemia in swine.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Endotoxins; Escherichia coli; Fatty Acids, Unsaturated; Female; Hydrazines; Hypertension, Pulmonary; Male; Receptors, Prostaglandin; Receptors, Thromboxane; Swine; Thromboxane A2 | 1987 |
Thromboxane receptor mediated vascular and airway changes in the presence of increased thromboxane biosynthesis in sheep endotoxemia.
Topics: Airway Resistance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Endotoxins; Fatty Acids, Unsaturated; Hydrazines; Pulmonary Circulation; Receptors, Prostaglandin; Receptors, Thromboxane; Sheep; Thromboxanes; Toxemia | 1987 |
Specific receptors for thromboxane A2 in cultured vascular smooth muscle cells of rat aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Fatty Acids, Unsaturated; Hydrazines; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1988 |
Thromboxane receptor-mediated bronchial and hemodynamic responses in ovine endotoxemia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Output; Eicosanoic Acids; Endotoxins; Fatty Acids, Unsaturated; Female; Gas Chromatography-Mass Spectrometry; Hemodynamics; Hydrazines; Lymph; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Receptors, Prostaglandin; Receptors, Thromboxane; Respiratory Distress Syndrome; Sepsis; Sheep; Vascular Resistance | 1988 |
Identification of thromboxane A2 receptor in cultured vascular endothelial cells of rat aorta.
Topics: Animals; Aorta; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Male; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane | 1988 |
Modulating role for thromboxane in the tubuloglomerular feedback response in the rat.
Topics: Analysis of Variance; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Hydrostatic Pressure; Imidazoles; Indomethacin; Kidney Glomerulus; Kidney Tubules; Male; Prostaglandins F; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1988 |
Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets.
Topics: Binding Sites; Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Kinetics; Platelet Aggregation; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1988 |
The role of thromboxane A2 in reperfusion injury.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Dogs; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Male; Myocardial Infarction; Receptors, Prostaglandin; Receptors, Thromboxane; Regional Blood Flow; Thromboxane A2 | 1988 |
Blockade of thromboxane and the prevention of eicosanoid-induced sudden death in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Bicyclic Monoterpenes; Bridged Bicyclo Compounds, Heterocyclic; Death, Sudden; Fatty Acids, Unsaturated; Fibrinolytic Agents; Hydrazines; Imidazoles; Injections, Intravenous; Male; Mice; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyridines; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombosis; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Beneficial effects of a new potent and specific thromboxane receptor antagonist (SQ-29,548) in vitro and in vivo.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Lysosomes; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Prostaglandin-Endoperoxide Synthases; Rabbits; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane B2; Thromboxane-A Synthase | 1985 |
Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arterial Occlusive Diseases; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Dibenzothiepins; Dogs; Fatty Acids, Unsaturated; Hydrazines; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides; Prostanoic Acids; Rats; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1986 |
Thromboxane agonist (U46619) potentiates norepinephrine efflux from adrenergic nerves.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Sympathetic Nervous System; Thromboxanes; Tritium; Vas Deferens | 1986 |
Anti-ischemic actions of a new thromboxane receptor antagonist, SQ-29,548, in acute myocardial ischemia.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Coronary Disease; Coronary Vessels; Creatine Kinase; Fatty Acids, Unsaturated; Heart Rate; Hemodynamics; Hydrazines; Male; Myocardium; Oxygen Consumption; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane | 1986 |
Platelet aggregation increases cholinergic neurotransmission in canine airway.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Fibers; Dogs; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Physostigmine; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Respiratory Physiological Phenomena; Synaptic Transmission; Thromboxane A2 | 1987 |
Analysis of airway responses to A23187 in the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcimycin; Cats; Dinoprost; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Meclofenamic Acid; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Prostaglandins F; Respiratory System | 1986 |
Mediation of reocclusion by thromboxane A2 and serotonin after thrombolysis with tissue-type plasminogen activator in a canine preparation of coronary thrombosis.
Topics: Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Coronary Thrombosis; Dogs; Fatty Acids, Unsaturated; Hydrazines; Ketanserin; Platelet Aggregation; Recombinant Proteins; Recurrence; Serotonin; Thromboxane A2; Tissue Plasminogen Activator | 1988 |
Antagonism of PAF-induced death in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Diterpenes; Epinephrine; Fatty Acids, Unsaturated; Furans; Ginkgolides; Hydrazines; Lactones; Male; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Pyridines; Thiazoles; Thromboxane A2 | 1988 |
Characterization of the responses to serotonin and prostanoids in human umbilical arteries perfused in vitro.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; In Vitro Techniques; Indomethacin; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins E; Prostaglandins F; Serotonin; Umbilical Arteries; Vasoconstriction; Vasodilation | 1986 |
Role of pressor prostanoids in rats with angiotensin II-salt-induced hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Animals; Arteries; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; Kidney Cortex; Male; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; Rats; Rats, Inbred Strains; Sodium Chloride; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1988 |
Influence of eicosanoids on renal function of DOCA-salt hypertensive rats.
Topics: Animals; Benzofurans; Body Water; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Hypertension; Kidney; Male; Meclofenamic Acid; Prostaglandins; Rats; Rats, Inbred Strains; Renal Circulation; Sodium; Sodium Chloride; Thromboxanes | 1988 |
Thromboxane A2 antagonist and diltiazem-induced enhancement of contractile function: the effect of timing of treatment.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Diltiazem; Dogs; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Myocardial Contraction; Perfusion; Thromboxane A2; Time Factors | 1988 |
Endothelial injury provokes collateral arterial vasoconstriction: response to a serotonin 2 antagonist, thromboxane antagonist or synthetase inhibition.
Topics: Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collateral Circulation; Endothelium, Vascular; Extremities; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; Ketanserin; Rabbits; Serotonin Antagonists; Species Specificity; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction | 1988 |
Thrombin is an important mediator of cyclic coronary blood flow variations due to platelet aggregation in stenosed canine coronary arteries.
Topics: Animals; Antithrombins; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Dogs; Fatty Acids, Unsaturated; Female; Heparin; Hydrazines; Ketanserin; Male; Pipecolic Acids; Platelet Aggregation; Sulfonamides; Thrombin; Thromboxane A2 | 1988 |
Bradykinin-induced vasoconstriction and thromboxane release in perfused human placenta.
Topics: Angiotensin II; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Indomethacin; Organ Culture Techniques; Placenta; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Thromboxane B2; Vascular Resistance; Vasoconstriction | 1988 |
Effect of thromboxane and serotonin receptor antagonists on intracoronary platelet deposition in dogs with experimentally stenosed coronary arteries.
Topics: Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Coronary Disease; Coronary Vessels; Dogs; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Male; Platelet Aggregation; Receptors, Serotonin; Serotonin Antagonists; Thromboxane A2 | 1988 |
Modulation of human monocyte leukotactic responsiveness by thromboxane A2 and 12-hydroxyheptadecatrienoic acid (12-HHT).
Topics: Bridged Bicyclo Compounds, Heterocyclic; Chemotactic Factors; Chemotaxis, Leukocyte; Dinoprostone; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Lymphokines; Monocytes; Prostaglandin Endoperoxides, Synthetic; Prostaglandins E; Radioimmunoassay; Thromboxane A2 | 1988 |
Effects of thromboxane A2 inhibition on osteogenic sarcoma cell-induced platelet aggregation.
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Fatty Acids, Unsaturated; Humans; Hydrazines; Methacrylates; Osteosarcoma; Platelet Aggregation; Thromboxane A2 | 1986 |
Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin).
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydrazines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylmethylsulfonyl Fluoride; Platelet Activating Factor; Platelet Aggregation | 1986 |
Thromboxane A2 mediates hemodynamic and respiratory dysfunction in graded bacteremia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aeromonas; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Cardiac Output; Epoprostenol; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Hypertension, Pulmonary; Hypoxia; Male; Prostaglandin Endoperoxides, Synthetic; Pulmonary Gas Exchange; Sepsis; Shock, Septic; Swine; Thromboxane A2; Thromboxane B2 | 1986 |
Role of the vascular endothelium in the contractile response to prostacyclin in the isolated rat aorta.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Endothelium; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Male; Methacrylates; Muscle, Smooth, Vascular; Prostaglandins E; Rats; Rats, Inbred Strains | 1986 |
Effect of macrophage stimulation on parasympathetic airway contraction in dogs.
Topics: Animals; Asthma; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Dogs; Electric Stimulation; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Macrophages; Muscle Contraction; Parasympathetic Nervous System; Thromboxane A2 | 1987 |
Spontaneous platelet aggregation: observations on potential mechanisms.
Topics: Adult; Apyrase; Aspirin; Blood Platelet Disorders; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; In Vitro Techniques; Methacrylates; Platelet Aggregation; Thromboxane A2; Yohimbine | 1987 |
Individual variations of prostanoid agonist responses in rabbit aorta: evidence for the independent regulation of prostanoid receptor subtypes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenotype; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Rabbits; Receptors, Prostaglandin | 1987 |
Synergism between a phosphodiesterase inhibitor and modulators of thromboxane formation on thrombin-induced sudden death in rabbits.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Death, Sudden; Drug Synergism; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; Indomethacin; Isoquinolines; Male; Pyridines; Rabbits; Tetrahydroisoquinolines; Thrombin; Thrombosis; Thromboxane A2; Thromboxane-A Synthase | 1987 |
Constriction of cat coronary arteries by synthetic thromboxane A2 and its antagonism.
Topics: Animals; Bicyclic Monoterpenes; Bridged Bicyclo Compounds, Heterocyclic; Cats; Coronary Vessels; Fatty Acids, Unsaturated; Hydrazines; Phenylacetates; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Sulfonamides; Thromboxane A2; Vasoconstriction | 1987 |
Implication of thromboxane in frusemide diuresis in rats.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dibenzothiepins; Diuresis; Drug Synergism; Fatty Acids, Unsaturated; Furosemide; Hydrazines; Male; Methacrylates; Osmolar Concentration; Rats; Rats, Inbred Strains; Sodium; Thromboxane A2; Thromboxane-A Synthase | 1986 |
Interaction of thromboxane A2 and tissue pathology during graded bacteremia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Kidney; Liver; Lung; Male; Myocardium; Prostaglandin Endoperoxides, Synthetic; Radioimmunoassay; Sepsis; Spleen; Swine; Thromboxane A2; Thromboxane B2 | 1987 |
Effects of a thromboxane synthetase inhibitor and a thromboxane antagonist on release and activity of thromboxane A2 and prostacyclin in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Epoprostenol; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; Imidazoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxidoreductases; Rats; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1985 |
Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Platelet Aggregation; Rats; Stereoisomerism; Stomach; Thromboxane A2; Thromboxanes; Trachea | 1985 |
Binding affinities of isocarbacyclin methyl ester and its free acid to prostanoid receptors.
Topics: Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Dinoprostone; Epoprostenol; Fatty Acids, Unsaturated; Fibrinolytic Agents; Guinea Pigs; Hydrazines; Iloprost; In Vitro Techniques; Mice; Platelet Aggregation Inhibitors; Rats; Receptors, Prostaglandin; Tumor Cells, Cultured | 1995 |
Thromboxane contributes to submaximal coronary dilation during myocardial ischemia.
Topics: Animals; Blood Gas Analysis; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Dogs; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Male; Microcirculation; Muscle Tonus; Thromboxanes; Vasodilation; Video Recording | 1995 |
Endothelium-dependent contractions to endothelin in the rat aorta are mediated by thromboxane A2.
Topics: Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Endothelins; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thromboxane A2; Thromboxane-A Synthase | 1993 |
Platelets increase the tone of quiescent rat aortic rings by release of serotonin and potentiate the subsequent contractile response to norepinephrine.
Topics: Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Apyrase; Arginine; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Endothelium, Vascular; Ergolines; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Thromboxane A2 | 1994 |
Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol.
Topics: Alkaloids; Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Chlorpheniramine; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Genistein; Histamine H1 Antagonists; Hydrazines; Imidazoles; Indomethacin; Isoflavones; Male; Marine Toxins; Methysergide; Platelet Aggregation Inhibitors; Polyenes; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Serotonin Antagonists; Staurosporine; Tetrodotoxin; Thromboxane A2; Thromboxane B2 | 1995 |
An EP receptor with a novel pharmacological profile in the T-cell line Jurkat.
Topics: Adenylyl Cyclases; Animals; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclic AMP; Dinoprost; Dinoprostone; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Leukemia, T-Cell; Prostaglandin D2; Rabbits; Receptors, Prostaglandin E; Swine; T-Lymphocytes; Tumor Cells, Cultured | 1995 |
15-Hydroxyeicosatetraenoic acid and diabetic endothelial dysfunction in rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 Enzyme Inhibitors; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; Fatty Acids, Unsaturated; Glucose; Hydrazines; Hydroxyeicosatetraenoic Acids; Imidazoles; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Proadifen; Prostaglandin H2; Prostaglandins H; Rabbits; Radioimmunoassay; Superoxide Dismutase; Thromboxane A2 | 1995 |
Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line, Transformed; Cells, Cultured; Chlorocebus aethiops; Cloning, Molecular; Consensus Sequence; DNA, Complementary; Epithelium; Fatty Acids, Unsaturated; Gene Expression; Glomerular Mesangium; Humans; Hydrazines; Kidney; Kidney Pelvis; Mice; Molecular Sequence Data; Muscle Proteins; Muscle, Smooth, Vascular; Oocytes; Rats; Receptors, Thromboxane; Recombinant Fusion Proteins; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Species Specificity; Xenopus laevis | 1995 |
Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Bronchoconstriction; Capillary Permeability; Chromones; Fatty Acids, Unsaturated; Furans; Guinea Pigs; Hydrazines; Hydroxyurea; Leukotriene D4; Lipoxygenase Inhibitors; Lung; Male; Meclofenamic Acid; Plasma; Prostaglandin Endoperoxides, Synthetic; Pyrilamine; Receptors, Thromboxane; SRS-A; Thromboxane A2; Trachea; Vasoconstrictor Agents | 1995 |
Intrinsic activity of the non-prostanoid thromboxane A2 receptor antagonist, daltroban (BM 13,505), in human platelets in vitro and in the rat vasculature in vivo.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Platelets; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hematocrit; Humans; Hydrazines; In Vitro Techniques; Male; Phenylacetates; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Sulfonamides; Thromboxane A2; Thromboxanes | 1995 |
Endothelin-induced contraction and mediator release in human bronchus.
Topics: Acetylcholine; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Dicarboxylic Acids; Endothelins; Fatty Acids, Unsaturated; Histamine Release; Humans; Hydrazines; In Vitro Techniques; Indomethacin; Inflammation; Leukotrienes; Lung; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth; Platelet Aggregation Inhibitors; Prostaglandins; Spectrometry, Fluorescence; SRS-A; Thromboxane A2; Triazoles | 1993 |
Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Docosahexaenoic Acids; Electron Spin Resonance Spectroscopy; Esterification; Fatty Acids, Unsaturated; Humans; Hydrazines; Linoleic Acid; Linoleic Acids; Membrane Fluidity; Membrane Lipids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 1995 |
Potentiation of PDGF-induced growth responses in coronary artery smooth muscle cells by thromboxane.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Electrophoresis; Fatty Acids, Unsaturated; Female; Hydrazines; Immunoblotting; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Radioligand Assay; Receptors, Thromboxane; Thromboxanes; Thymidine | 1995 |
Endogenous synthesis of endothelin-1 may mediate a delayed pressor response after injection of endothelin-1 in rats.
Topics: Alanine; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Enalaprilat; Endothelin Receptor Antagonists; Endothelins; Fatty Acids, Unsaturated; Glycopeptides; Hydrazines; Injections, Intravenous; Male; Peptides, Cyclic; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane | 1995 |
Diaphragmatic failure during group B streptococcal sepsis in piglets: the role of thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Gas Analysis; Bridged Bicyclo Compounds, Heterocyclic; Diaphragm; Electric Stimulation; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Indomethacin; Muscle Contraction; Pressure; Prostaglandin Endoperoxides, Synthetic; Pulmonary Gas Exchange; Receptors, Thromboxane; Regional Blood Flow; Respiratory Mechanics; Streptococcal Infections; Streptococcus agalactiae; Swine; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Endothelium-dependent contraction induced by acetylcholine in isolated rat renal arteries.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arginine; Aspirin; Atropine; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hexamethonium; Hydrazines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroarginine; Phospholipases A; Quinacrine; Rats; Rats, Inbred WKY; Receptors, Prostaglandin; Renal Artery; Terpenes; Thromboxane A2; Thromboxane-A Synthase | 1995 |
Sequential agonist activation and site-specific mediation of acute cyclosporine constriction in rat renal arterioles.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cyclosporine; Endothelin Receptor Antagonists; Endothelins; Fatty Acids, Unsaturated; Furans; Hydrazines; Kidney; Peptides, Cyclic; Platelet Activating Factor; Prostaglandins H; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 1994 |
Low-density lipoprotein stimulation of mesangial cell fibronectin synthesis: role of protein kinase C and transforming growth factor-beta.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Fatty Acids, Unsaturated; Female; Fibronectins; Glomerular Mesangium; Hydrazines; Indoles; Intracellular Signaling Peptides and Proteins; Lipoproteins, LDL; Maleimides; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phorbol 12,13-Dibutyrate; Phosphorylation; Piroxicam; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Thromboxane A2; Transforming Growth Factor beta | 1995 |
Renal vasoconstriction with U-46,619; role of arachidonate metabolites.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hemodynamics; Hydrazines; Leukotrienes; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Renal Circulation; Thromboxane A2; Vascular Resistance; Vasoconstriction | 1994 |
In vivo effects of a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) partial agonist, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]- bicyclohept-2-exo-yl]-heptenoic acid [(+)-S-145], on vascular, platelet and cardiac function.
Topics: Animals; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Guinea Pigs; Hemodynamics; Hydrazines; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2 | 1995 |
Tone-dependent responses of histamine in feline pulmonary vascular bed.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cats; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Histamine; Histamine Agonists; Histamine Antagonists; Hydrazines; Meclofenamic Acid; Pulmonary Circulation; Receptors, Thromboxane; Vasomotor System | 1995 |
TxA2 receptor activation elicits organ-specific increases in microvascular permeability in the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Proteins; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Fatty Acids, Unsaturated; Hematocrit; Hemodynamics; Hydrazines; Male; Microcirculation; Nephrectomy; Osmolar Concentration; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Serum Albumin; Splenectomy; Thromboxane A2 | 1995 |
Beneficial effects of combined thromboxane and leukotriene receptor antagonism in hemorrhagic shock.
Topics: Acetophenones; Animals; Blood Pressure; Blood Volume; Bridged Bicyclo Compounds, Heterocyclic; Cathepsin D; Fatty Acids, Unsaturated; Hydrazines; Leukotriene Antagonists; Leukotriene D4; Leukotriene E4; Male; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Shock, Hemorrhagic; Tetrazoles; Thromboxane A2 | 1995 |
Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: additional evidence for the existence of a unique isoprostane receptor.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Fatty Acids, Unsaturated; Humans; Hydrazines; Isomerism; Isoprostanes; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins H; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2 | 1994 |
Different effects of endothelin-3 on the Ca2+ discharge induced by agonists and Ca(2+)-ATPase inhibitors in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Antioxidants; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Agonists; Calcium-Transporting ATPases; Endothelins; Fatty Acids, Unsaturated; Fura-2; Humans; Hydrazines; Hydroquinones; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Endothelin; Receptors, Thromboxane; Terpenes; Thapsigargin; Thrombin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Reduced thromboxane receptor affinity and vasoconstrictor responses in placentae from diabetic pregnancies.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Placenta; Pregnancy; Pregnancy in Diabetics; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Thromboxane A2; Thromboxane B2; Vasoconstriction; Vasoconstrictor Agents | 1994 |
Interactions of nonprostanoid trimetoquinol analogs with thromboxane A2/prostaglandin H2 receptors in human platelets, rat vascular endothelial cells and rat vascular smooth muscle cells.
Topics: Adrenergic beta-Agonists; Animals; Aorta, Thoracic; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Endothelium, Vascular; Fatty Acids, Unsaturated; Humans; Hydrazines; Kinetics; Male; Models, Biological; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Structure-Activity Relationship; Tretoquinol; Tritium | 1993 |
Cyclooxygenase inhibitors depress norepinephrine constriction of rat abdominal, but not thoracic, aorta.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Aorta, Abdominal; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Dinoprost; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Male; Mefenamic Acid; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Thromboxane; Serotonin; Species Specificity | 1994 |
Agents combining thromboxane receptor antagonism with thromboxane synthase inhibition: [[[2-(1H-imidazol-1-yl)ethylidene]amino]oxy]alkanoic acids.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Computer Simulation; Dogs; Fatty Acids, Unsaturated; Fibrinolytic Agents; Humans; Hydrazines; Imidazoles; Male; Models, Molecular; Molecular Structure; Pentanoic Acids; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Stereoisomerism; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1994 |
Alterations in glomerular dynamics in congenital, unilateral hydronephrosis.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Hydronephrosis; Imidazoles; Kidney Glomerulus; Losartan; Male; Rats; Rats, Inbred Strains; Rats, Wistar; Saralasin; Tetrazoles; Thromboxane A2 | 1994 |
Prostaglandin B2-induced pulmonary hypertension is mediated by TxA2/PGH2 receptor stimulation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hypertension, Pulmonary; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins B; Prostaglandins H; Pulmonary Circulation; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1994 |
Modulation of phorbol ester-induced contraction by endogenously released cyclooxygenase products in rat aorta.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Kinetics; Male; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins, Synthetic; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thromboxane A2; Time Factors | 1994 |
Thromboxane A2 receptor antagonism prevents hormonal and cardiovascular responses to mineral acid infusion.
Topics: Adrenocorticotropic Hormone; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Heart Rate; Hematocrit; Hormones; Hydrazines; Hydrochloric Acid; Hydrocortisone; Infusions, Intravenous; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Sheep; Thromboxane A2; Thromboxane B2; Time Factors | 1994 |
Increased thromboxane mediates the adverse renal effects of interleukin-2 in rats.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Creatinine; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Interleukin-2; Kidney; Male; Prostaglandin Antagonists; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Thromboxane; Thromboxane B2; Thromboxanes; Time Factors | 1994 |
Functional significance of pharmacological blocking of renal thromboxane in old and young rat kidneys.
Topics: Aging; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Imidazoles; Kidney; Male; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxanes | 1994 |
Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Bridged Bicyclo Compounds, Heterocyclic; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary; Down-Regulation; Endothelium, Vascular; Fatty Acids, Unsaturated; Humans; Hydrazines; Molecular Sequence Data; Placenta; Receptors, Thromboxane; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thromboxane A2; Transfection | 1994 |
Thromboxane receptor blockade (SQ 29,548) in group B streptococcal toxin challenge in young lambs.
Topics: Airway Resistance; Animals; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Output; Disease Models, Animal; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Lung; Pulmonary Gas Exchange; Receptors, Thromboxane; Respiratory Mechanics; Sheep; Streptococcal Infections; Streptococcus agalactiae; Stroke Volume; Thromboxane A2; Vascular Resistance | 1994 |
Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Male; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents; Vasomotor System | 1994 |
Modulation of thromboxane receptor activation in rat glomerular mesangial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Fatty Acids, Unsaturated; Glomerular Mesangium; Hydrazines; Inositol Phosphates; Intracellular Membranes; Prostaglandin Endoperoxides, Synthetic; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Thromboxane; Thromboxane A2; Thromboxanes | 1994 |
Prevention of thromboxane A2 receptor-mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Enalapril; Fatty Acids, Unsaturated; Hematocrit; Hydrazines; Hypertension, Pulmonary; Imidazoles; Losartan; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Tetrazoles; Thromboxane A2 | 1994 |
Agonist-induced phosphorylation of human platelet TXA2/PGH2 receptors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chromatography, Affinity; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Kinetics; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Vasoconstrictor Agents | 1994 |
Diabetes-induced endothelial dysfunction in streptozotocin-treated rats: role of prostaglandin endoperoxides and free radicals.
Topics: Animals; Arginine; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelium, Vascular; Fatty Acids, Unsaturated; Free Radical Scavengers; Free Radicals; Hydrazines; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin Endoperoxides; Rats; Rats, Inbred WKY; Receptors, Thromboxane; Renal Artery; Superoxide Dismutase; Thiourea; Vasodilation | 1993 |
Interaction of human platelets and leukocytes in modulation of vascular tone.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Animals; Arginine; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Carotid Artery, Common; Ergolines; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Muscle Tonus; Muscle, Smooth, Vascular; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroarginine; Nitroprusside; Phenylephrine; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Thromboxane; Serotonin Antagonists; Superoxide Dismutase; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1994 |
Hemodynamic effects of brief pulmonary hemostasis.
Topics: Animals; Blood Platelets; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; Erythrocytes; Fatty Acids, Unsaturated; Hemodynamics; Hemostasis; Hydrazines; In Vitro Techniques; Indomethacin; Papaverine; Perfusion; Platelet Aggregation Inhibitors; Platelet Count; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Thromboxane A2; Vascular Resistance | 1993 |
The effects of thromboxane inhibitors on the microvascular and tumor response to photodynamic therapy.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Chondrosarcoma; Fatty Acids, Unsaturated; Female; Flunarizine; Hydrazines; Pentanoic Acids; Photochemotherapy; Pyridines; Rats; Rats, Sprague-Dawley; Thromboxanes; Vasoconstriction | 1993 |
Contractile effect of endothelin in human placental veins: role of endothelium prostaglandins and thromboxane.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Bridged Bicyclo Compounds, Heterocyclic; Endothelins; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Imidazoles; In Vitro Techniques; Indomethacin; Placenta; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents; Veins | 1993 |
Reduction in the number of thromboxane receptors on human platelets after exposure to GR32191.
Topics: Binding, Competitive; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Down-Regulation; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; In Vitro Techniques; Ligands; Platelet Aggregation Inhibitors; Radioligand Assay; Receptors, Thromboxane; Sulfonamides | 1993 |
Endothelial dysfunction augments myogenic arteriolar constriction in hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arachidonic Acid; Arterioles; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; In Vitro Techniques; Indomethacin; Male; Muscles; Nitroprusside; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins; Prostaglandins H; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents | 1993 |
Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chromatography, Affinity; Fatty Acids, Unsaturated; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Hydrazines; Immunoblotting; Kinetics; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstrictor Agents | 1993 |
Potentiation of norepinephrine-induced contraction by primary prostaglandin receptor activation in rat aorta.
Topics: Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Dinoprost; Dinoprostone; Drug Synergism; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin | 1993 |
6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Drug Design; Fatty Acids, Unsaturated; Humans; Hydrazines; Molecular Conformation; Molecular Structure; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Receptors, Thromboxane; Structure-Activity Relationship; Thromboxane A2; Thromboxane-A Synthase; Tritium | 1994 |
Lipid peroxidation increases arterial cyclooxygenase activity during pregnancy.
Topics: Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Lipid Peroxidation; Malondialdehyde; Mesenteric Arteries; Methacholine Chloride; Nitroprusside; Pregnancy; Pregnancy, Animal; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Vasodilation; Vitamin E Deficiency | 1994 |
Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig.
Topics: Acetylcholine; Animals; Atropine; Bridged Bicyclo Compounds, Heterocyclic; Bronchoconstrictor Agents; Dinoprost; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Prostaglandin D2; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; Thromboxane A2; Trachea | 1994 |
Differences in vascular response to thromboxane between intestinal mucosa and muscularis.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Fatty Acids, Unsaturated; Female; Hydrazines; Infusions, Intra-Arterial; Intestinal Mucosa; Jejunum; Male; Microspheres; Muscle, Smooth; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Regional Blood Flow; Thromboxane A2 | 1993 |
Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Cells, Cultured; Dinoprost; DNA; Fatty Acids, Unsaturated; Hydrazines; Inositol 1,4,5-Trisphosphate; Male; Muscle, Smooth, Vascular; Rats; Receptors, Thromboxane; Transfection | 1993 |
Products of cyclooxygenase mediate the responses of the guinea pig trachea to hydrogen peroxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Epithelium; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; Hydrogen Peroxide; Imidazoles; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Radioimmunoassay; Receptors, Thromboxane; Thromboxane-A Synthase; Trachea; Vasoconstrictor Agents | 1993 |
Characterization of (5Z)-7-[3-endo-[(4-iodophenylsulfonyl) amino] -bicyclo[2.2.1]hep-2-exo-yl]heptenoic acid (IS-145) as an antagonist for the study of thromboxane A2 receptor.
Topics: Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; GTP Phosphohydrolases; Guanosine Triphosphate; Humans; Hydrazines; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Radioligand Assay; Receptors, Thromboxane | 1993 |
The in vivo antiplatelet effects of thromboxane A2 synthase inhibitors are potentiated by simultaneous thromboxane A2/prostaglandin H2 receptor blockade.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Epinephrine; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; Male; Phthalic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane-A Synthase | 1993 |
Activation of protein kinase C reduces thromboxane receptors in glomeruli and mesangial cells.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Enzyme Activation; Fatty Acids, Unsaturated; Female; Glomerular Mesangium; Glucose; Hydrazines; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kidney Glomerulus; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane | 1993 |
Thromboxane A2 receptors in equine monocytes: identification of a new subclass of TXA2 receptors.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Cell Membrane; Cell Separation; Cyclic AMP; Fatty Acids, Unsaturated; Horses; Hydrazines; Iodine Radioisotopes; Kinetics; Monocytes; Radioligand Assay; Receptors, Thromboxane; Tumor Necrosis Factor-alpha | 1993 |
Antiplatelet activity of 2-(6-carboxyhexyl)-3-n-hexylcyclohexylamine (IBI P-05006), a thromboxane receptor antagonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cyclic AMP; Cyclohexylamines; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Radioligand Assay; Receptors, Thromboxane | 1993 |
Vascular smooth muscle actions and receptor interactions of 8-iso-prostaglandin E2, an E2-isoprostane.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dinoprostone; Enzyme Activation; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Inositol 1,4,5-Trisphosphate; Isomerism; Isoprostanes; Kidney; Kinetics; Male; Muscle, Smooth, Vascular; Phospholipases; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Thromboxane; Regional Blood Flow | 1993 |
Role of endothelium in endothelin-evoked contractions in the rat aorta.
Topics: Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Endothelins; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hypertension; In Vitro Techniques; Indomethacin; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thromboxane B2; Vasoconstriction | 1993 |
The effect of thromboxane A2 receptor antagonism on amphotericin B-induced renal vasoconstriction in the rat.
Topics: Amphotericin B; Animals; Blood Flow Velocity; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Ibuprofen; Male; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Renal Artery; Vasoconstriction | 1993 |
Endogenous prostaglandin endoperoxides may alter infarct size in the presence of thromboxane synthase inhibition: studies in a rabbit model of coronary artery occlusion-reperfusion.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Pentanoic Acids; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Pyridines; Rabbits; Receptors, Thromboxane; Thromboxane-A Synthase | 1993 |
Pharmacological profile of BMS 180,291: a potent, long-acting, orally active thromboxane A2/prostaglandin endoperoxide receptor antagonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Oral; Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Coronary Vessels; Dinoprostone; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; In Vitro Techniques; Male; Mice; Muscle Contraction; Oxazoles; Platelet Aggregation; Propionates; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Swine; Thromboxane B2; Trachea | 1993 |
Characterization of glomerular thromboxane receptors in murine lupus nephritis.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Kidney Glomerulus; Lupus Nephritis; Mice; Mice, Inbred Strains; Receptors, Thromboxane; Thromboxanes | 1993 |
Thromboxane contributes to pulmonary hypertension in ischemia-reperfusion lung injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hypertension, Pulmonary; In Vitro Techniques; Ischemia; Lung; Organ Size; Pulmonary Circulation; Pulmonary Edema; Rabbits; Radioimmunoassay; Receptors, Thromboxane; Reperfusion Injury; Thromboxane A2; Thromboxane B2; Thromboxanes; Vasoconstriction | 1993 |
Airway and vascular effects of 8-epi-prostaglandin F2 alpha in isolated perfused rat lung.
Topics: Air Pressure; Airway Resistance; Animals; Arginine; Atrial Natriuretic Factor; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Lung; Lung Compliance; Microcirculation; Nitroarginine; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Respiratory Mechanics; Tidal Volume; Vasoconstrictor Agents | 1993 |
Thromboxane binding and signal transduction in rat glomerular mesangial cells.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Heptanoic Acids; Hydrazines; Inositol Phosphates; Intracellular Signaling Peptides and Proteins; Kidney Glomerulus; Kinetics; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C; Proteins; Rats; Signal Transduction; Thromboxanes | 1993 |
Tone-dependent responses of 5-hydroxytryptamine in the feline pulmonary vascular bed are mediated by two different 5-hydroxytryptamine receptors.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cats; Fatty Acids, Unsaturated; Hydrazines; Ketanserin; Lung; Meclofenamic Acid; Propanolamines; Pulmonary Artery; Pulmonary Circulation; Receptors, Serotonin; Serotonin; Vascular Resistance; Vasoconstriction | 1993 |
Binding and function of a potent new thromboxane receptor antagonist, BMS 180,291, in human platelets.
Topics: Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; In Vitro Techniques; Kinetics; Oxazoles; Platelet Aggregation; Propionates; Receptors, Thromboxane | 1993 |
Cardiac-derived thromboxane A2. An initiating mediator of reperfusion injury?
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Output; Cardioplegic Solutions; Coronary Circulation; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Stroke Volume; Thromboxane A2; Thromboxane B2 | 1993 |
Thromboxane receptor antagonism and synthase inhibition in cerebral ischemia.
Topics: Animals; Brain Ischemia; Bridged Bicyclo Compounds, Heterocyclic; Cerebrovascular Circulation; Drug Synergism; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; Male; Rats; Rats, Wistar; Receptors, Thromboxane; Regional Blood Flow; Thromboxane-A Synthase | 1993 |
Identification of functional PGH2/TxA2 receptors on human endothelial cells.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Osmolar Concentration; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Spectrometry, Fluorescence | 1993 |
Angiotensin or thromboxane receptor antagonism in rats with congenital hydronephrosis.
Topics: Angiotensin Receptor Antagonists; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Hydronephrosis; Male; Rats; Rats, Wistar; Receptors, Angiotensin; Receptors, Thromboxane; Saralasin | 1993 |
Cyclooxygenase-dependent vasoconstrictor alters vascular function in the vitamin E-deprived rat.
Topics: Animals; Aorta; Arachidonic Acids; Arginine; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Lipid Peroxidation; Meclofenamic Acid; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation; Vitamin E Deficiency | 1993 |
AGN 191976: a novel thromboxane A2-mimetic with ocular hypotensive properties.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Animals; Antihypertensive Agents; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Conjunctiva; Dogs; Fatty Acids, Unsaturated; Female; Guinea Pigs; Humans; Hydrazines; Intraocular Pressure; Macaca fascicularis; Male; Muscle, Smooth; Ocular Hypertension; Ophthalmic Solutions; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pupil; Receptors, Thromboxane; Thromboxane A2; Tonometry, Ocular; Vasoconstrictor Agents | 1995 |
Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists.
Topics: Adenosine Diphosphate; Blood Viscosity; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Drug Synergism; Epinephrine; Fatty Acids, Unsaturated; Hematopoietic Cell Growth Factors; Hirudins; Humans; Hydrazines; Interleukins; Oligopeptides; Platelet Aggregation; Recombinant Proteins; Serotonin; Stress, Mechanical; Thrombin; Thrombopoietin; Vasopressins | 1996 |
Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Endothelium, Vascular; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Prostaglandins; Prostaglandins F; Prostaglandins H; Rats; Rats, Inbred F344; Rats, Inbred SHR; Rats, Inbred WKY | 1996 |
Thromboxane A2 receptor-mediated signal transduction in rabbit aortic smooth muscle cells.
Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phosphatidylinositols; Rabbits; Receptors, Thromboxane; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Labeling of human platelet plasma membrane thromboxane A2/prostaglandin H2 receptors using SQB, a novel biotinylated receptor probe.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Biotin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Humans; Hydrazines; Microscopy, Fluorescence; Molecular Probes; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Spectrometry, Fluorescence; Sulfonamides; Thromboxane A2 | 1996 |
Intracellular signaling by 8-epi-prostaglandin F2 alpha is mediated by thromboxane A2/prostaglandin endoperoxide receptors in porcine carotid arteries.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium-Calmodulin-Dependent Protein Kinases; Carotid Arteries; Dinoprost; F2-Isoprostanes; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Muscle, Smooth, Vascular; Myosin Light Chains; Oxazoles; Phosphorylation; Receptors, Prostaglandin; Receptors, Thromboxane; Signal Transduction; Swine; Vasoconstriction | 1996 |
Regulation of endothelin-1 production by a thromboxane A2 mimetic in rat heart smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Endothelins; Fatty Acids, Unsaturated; Gene Expression; Hydrazines; Isoquinolines; Muscle, Smooth; Myocardium; Piperazines; Promoter Regions, Genetic; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rats; Receptors, Thromboxane; RNA, Messenger; Thromboxane A2 | 1996 |
Both nitric oxide and prostaglandin-mediated responses are impaired in skeletal muscle arterioles of hypertensive rats.
Topics: Acetylcholine; Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Calcimycin; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Male; Muscle, Skeletal; Nitric Oxide; Nitroarginine; Nitroprusside; Prostaglandins H; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Substance P | 1996 |
Aqueous smokeless tobacco extract impairs endothelium-dependent vasodilation in the oral mucosa.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cricetinae; Cyclooxygenase Inhibitors; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Male; Mesocricetus; Mouth Mucosa; Muscle Tonus; Plant Extracts; Plants, Toxic; Tobacco, Smokeless; Vasodilation; Vasodilator Agents | 1996 |
On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel.
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydrazines; Molecular Structure; Pentanoic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Receptors, Thromboxane; Structure-Activity Relationship; Thromboxane-A Synthase; Tritium | 1996 |
Site-directed mutagenesis of cysteinyl and serine residues of human thromboxane A2 receptor in insect cells.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cloning, Molecular; Cysteine; Disulfides; DNA Primers; DNA, Complementary; Fatty Acids, Unsaturated; Humans; Hydrazines; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Receptors, Thromboxane; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Spodoptera | 1996 |
Differences between cytokine effects in the microcirculation of the rat.
Topics: Animals; Arterioles; Blood Circulation; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Interleukin-1; Interleukin-6; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Recombinant Proteins; Time Factors; Tumor Necrosis Factor-alpha | 1996 |
Evidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alpha.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F, Synthetic; Receptors, Thromboxane; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Thromboxane A2 receptor blockade suppresses intercellular adhesion molecule-1 expression by stimulated vascular endothelial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cyclic AMP; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydrazines; Intercellular Adhesion Molecule-1; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Protein Kinase Inhibitors; Protein Kinases; Radioligand Assay; Receptors, Thromboxane; Thromboxane A2; Tumor Necrosis Factor-alpha | 1996 |
Indomethacin and thromboxane A2/prostaglandin H2 antagonist SQ29,548 impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Phenylephrine; Potassium; Prostaglandin H2; Prostaglandins H; Rats; Rats, Wistar; Receptors, Thromboxane; Thromboxane B2; Vasoconstriction | 1996 |
Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amino Acid Sequence; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Cloning, Molecular; Electrophysiology; Fatty Acids, Unsaturated; Hydrazines; Kidney; Male; Molecular Sequence Data; Oocytes; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Sequence Alignment; Sequence Analysis; Thromboxane A2; Xenopus laevis | 1996 |
Cigarette smoke-induced bronchoconstriction: causative agents and role of thromboxane receptors.
Topics: Air Pressure; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bronchial Diseases; Bronchoalveolar Lavage Fluid; Cholinergic Antagonists; Constriction, Pathologic; Dinoprost; Fatty Acids, Unsaturated; Guinea Pigs; Hemodynamics; Hexamethonium; Hydrazines; Male; Nicotine; Nicotinic Agonists; Receptors, Thromboxane; Smoke; Smoking | 1996 |
Thromboxane A2 stimulates mitogen-activated protein kinase and arachidonic acid liberation in rabbit platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Blood Platelets; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Fatty Acids, Unsaturated; Hydrazines; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorus Radioisotopes; Phosphorylation; Prostaglandin Endoperoxides, Synthetic; Protein-Tyrosine Kinases; Rabbits; Thromboxane A2; Time Factors; Vasoconstrictor Agents | 1996 |
8-Isoprostaglandin F2 alpha, a product of lipid peroxidation, increases portal pressure in normal and cirrhotic rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; F2-Isoprostanes; Fatty Acids, Unsaturated; Hydrazines; Lipid Peroxidation; Liver Cirrhosis, Experimental; Male; Portal Pressure; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents | 1997 |
Impairment of vascular function is associated with an age-related increase of lipid peroxidation in rats.
Topics: Aging; Animals; Arteries; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; Lipid Peroxides; Meclofenamic Acid; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 1996 |
Nitric oxide regulation of TP receptor-mediated pulmonary vasoconstriction in the anesthetized, open-chest rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthesia, General; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heart Rate; Hemodynamics; Hydrazines; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 1996 |
Direct evidence that thromboxane mimetic U44069 preferentially constricts the afferent arteriole.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Kidney Glomerulus; Male; Nifedipine; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction | 1997 |
Differential involvement of serotonin 2A/C and thromboxane A2/prostanoid receptors in high- vs. low-shear rate arterial thrombosis in rabbits.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Carotid Stenosis; Endothelium, Vascular; Fatty Acids, Unsaturated; Heart Rate; Hemodynamics; Hydrazines; Jugular Veins; Ketanserin; Male; Oxadiazoles; Piperazines; Platelet Aggregation; Prazosin; Rabbits; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Prostaglandin; Receptors, Serotonin; Receptors, Thromboxane; Ritanserin; Serotonin Antagonists; Stress, Mechanical | 1997 |
Arginine vasopressin interacts with thromboxane in hydronephrosis.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Arterioles; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hydronephrosis; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Reference Values; Renal Circulation; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction | 1997 |
Histamine-induced contraction of human isolated bronchus is enhanced by endogenous prostaglandin F2 alpha and activation of TP receptors.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Carbachol; Cholinergic Agonists; Dinoprost; Fatty Acids, Unsaturated; Histamine; Humans; Hydrazines; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Receptors, Prostaglandin | 1997 |
Protective actions of a thromboxane receptor antagonist, SQ 29548 on the ischemic myocardium: morphologic and hemodynamic effects.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Fatty Acids, Unsaturated; Female; Heart Rate; Hemodynamics; Hydrazines; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Necrosis; Receptors, Thromboxane; Thromboxane A2 | 1997 |
Thromboxane A2 receptor mediation of calcium and calcium transients in rat cardiomyocytes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Fatty Acids, Unsaturated; Heart; Hydrazines; Myocardium; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Wistar; Receptors, Thromboxane; Thromboxane A2 | 1997 |
Isoprostanes: free radical-generated prostaglandins with constrictor effects on cerebral arterioles.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dinoprostone; F2-Isoprostanes; Fatty Acids, Unsaturated; Free Radicals; Hydrazines; Isoprostanes; Male; Pia Mater; Prostaglandins; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents | 1997 |
Structural determinants for agonist binding affinity to thromboxane/prostaglandin endoperoxide (TP) receptors. Analysis of chimeric rat/human TP receptors.
Topics: Amino Acid Sequence; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydrazines; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Recombinant Fusion Proteins; Structure-Activity Relationship | 1997 |
Evidence for the distinct nature of F2-isoprostane receptors from those of thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aequorin; Animals; Aorta; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Dinoprost; DNA, Complementary; Enzyme Activation; F2-Isoprostanes; Fatty Acids, Unsaturated; Glomerular Mesangium; Humans; Hydrazines; Kidney Glomerulus; Kinetics; Male; Muscle, Smooth, Vascular; Oocytes; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Recombinant Fusion Proteins; Recombinant Proteins; Thromboxane A2; Xenopus laevis | 1997 |
Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Deferoxamine; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Hydrazines; Hydrogen Peroxide; Leukotrienes; Lipid Peroxides; Oligopeptides; Peroxides; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; tert-Butylhydroperoxide; Thromboxane B2; Vitamin E | 1997 |
Hemodynamic effects of isoprostanes (8-iso-prostaglandin F2alpha and E2) in isolated guinea pig hearts.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Dinoprost; Dinoprostone; Endothelin-1; F2-Isoprostanes; Fatty Acids, Unsaturated; Guinea Pigs; Heart Rate; Hemodynamics; Hydrazines; In Vitro Techniques; Isoprostanes; Lactic Acid; Male; Myocardial Contraction; Myocardium; Pyruvic Acid; Receptors, Thromboxane; Vasoconstrictor Agents | 1997 |
Low-affinity thromboxane receptor mediates proliferation in cultured vascular smooth muscle cells of rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amino Acid Sequence; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cells, Cultured; DNA; Enzyme Activation; Fatty Acids, Unsaturated; Guanosine Triphosphate; Hydrazines; Inositol Phosphates; Ligands; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Muscle, Smooth, Vascular; Peptides; Phosphotyrosine; Prostaglandin Endoperoxides, Synthetic; Protein Kinases; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Thromboxane; Thromboxane A2 | 1997 |
Pharmacological evidence for thromboxane receptor heterogeneity--implications for the eye.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Cats; Chickens; Conjunctiva; Dogs; Eye; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; Intraocular Pressure; Muscle Contraction; Muscle, Smooth; Ocular Hypotension; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pupil; Rats; Receptors, Thromboxane; Thromboxane A2; Vasoconstrictor Agents | 1997 |
A comparative study of thromboxane (TP) receptor mimetics and antagonists on isolated human umbilical artery and myometrium.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Myometrium; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Umbilical Arteries | 1997 |
Losartan prevents thromboxane A2/prostanoid (TP) receptor mediated increase in microvascular permeability in the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Enalapril; Fatty Acids, Unsaturated; Hematocrit; Hydrazines; Losartan; Male; Microcirculation; Plasma Volume; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Thromboxane; Serum Albumin; Vasoconstrictor Agents | 1997 |
Evidence for partial agonist properties of daltroban (BM 13,505) at TP receptors in the anaesthetized open-chest rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hypertension, Pulmonary; Male; Phenylacetates; Rats; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1997 |
Role of endothelium in the endothelin-1-mediated potentiation of the norepinephrine response in the aorta of hypertensive rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Male; Nifedipine; Norepinephrine; Oligopeptides; Peptides, Cyclic; Piperidines; Piroxicam; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Endothelin; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Endothelin and prostaglandin H2 enhance arteriolar myogenic tone in hypertension.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Endothelins; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Male; Muscle, Smooth, Vascular; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasomotor System | 1997 |
Analysis of the pulmonary hypertensive effects of the isoprostane derivative, 8-iso-PGF2alpha, in the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dose-Response Relationship, Drug; F2-Isoprostanes; Fatty Acids, Unsaturated; Hydrazines; Hypertension, Pulmonary; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Vasoconstrictor Agents | 1997 |
Autacoids mediate coronary vasoconstriction induced by nitric oxide synthesis inhibition.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Autacoids; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Vessels; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Free Radical Scavengers; Hydrazines; Imidazoles; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Prostaglandin H2; Prostaglandins H; Pyridines; Rats; Superoxides; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents | 1997 |
The bovine thromboxane A2 receptor: molecular cloning, expression, and functional characterization.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; COS Cells; DNA, Complementary; Endothelium, Vascular; Fatty Acids, Unsaturated; Gene Library; Humans; Hydrazines; Molecular Sequence Data; Prostaglandins; Radioligand Assay; Receptors, Thromboxane; Sequence Homology; Transfection | 1998 |
Platelet hypoaggregability in hereditary hypertriglyceridemic rats: relation to plasma triglycerides.
Topics: Adenosine Diphosphate; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Hypertriglyceridemia; Kinetics; Male; Platelet Aggregation; Rats; Rats, Inbred Lew; Receptors, Thromboxane; Thrombin; Triglycerides | 1997 |
Regulation of the vasomotor activity of lymph microvessels by nitric oxide and prostaglandins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Endothelium, Lymphatic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Lymphatic System; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Perfusion; Prostaglandins; Rats; Rats, Wistar | 1998 |
Intracellular Ca2+ elevation and contraction due to prostaglandin F2alpha in rat aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Calcium Channels; Dinoprost; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Verapamil | 1997 |
Modification on ligand binding to TXA2/PGH2 receptors by diethylpyrocarbonate.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Diethyl Pyrocarbonate; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2 | 1997 |
Growth inhibitory effects of thromboxane antagonists on breast cancer cell lines: a preliminary study.
Topics: Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Phenylacetates; Prostaglandins, Synthetic; Sulfonamides; Thromboxanes; Tumor Cells, Cultured | 1997 |
Augmented endothelium-dependent contraction to angiotensin II in the SHR aorta: role of an inducible cyclooxygenase metabolite.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Cycloheximide; Cyclooxygenase Inhibitors; Dactinomycin; Endothelium, Vascular; Enzyme Induction; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Nitrobenzenes; Piroxicam; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Synthesis Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sulfonamides; Time Factors; Vasoconstrictor Agents | 1998 |
Chemically induced platelet lysis causes vasoconstriction by release of serotonin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Endothelium, Vascular; Ergolines; Fatty Acids, Unsaturated; Hemostatics; Hydrazines; In Vitro Techniques; Ketanserin; L-Lactate Dehydrogenase; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents; Vitamin K | 1998 |
The role of N-glycosylation of human thromboxane A2 receptor in ligand binding.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Baculoviridae; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; COS Cells; Dinoprost; F2-Isoprostanes; Fatty Acids, Unsaturated; Glycoproteins; Glycosylation; Humans; Hydrazines; Ligands; Mutation; Protein Binding; Receptors, Thromboxane; Recombinant Proteins; RNA, Messenger; Spodoptera; Tunicamycin | 1998 |
Cyclooxygenase inhibition aggravates ischemia-reperfusion injury in the perfused guinea pig heart: involvement of isoprostanes.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Dinoprost; Fatty Acids, Unsaturated; Guinea Pigs; Heart; Hemodynamics; Hydrazines; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Receptors, Thromboxane; Vascular Resistance; Vasoconstriction | 1998 |
A sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis.
Topics: Acetates; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Dual Specificity Phosphatase 2; Fatty Acids, Unsaturated; Flow Cytometry; Humans; Hydrazines; Integrins; Microscopy, Fluorescence; Peptide Fragments; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Signal Transduction; Thromboxane A2; Tyrosine | 1998 |
Thromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Fatty Acids, Unsaturated; Fibrinolysin; Fibrinolysis; Glomerular Mesangium; Hydrazines; Kinetics; Plasminogen Activator Inhibitor 1; Rats; Receptors, Thromboxane; Recombinant Proteins; RNA, Messenger; Thromboxane A2; Tissue Plasminogen Activator; Transcription, Genetic; Transfection | 1998 |
Effects of the selective cyclooxygenase-2 inhibitor nimesulide on vascular contractions in endothelium-denuded rat aorta.
Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelin-1; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Muscle Contraction; Nifedipine; Phenylephrine; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides | 1998 |
Biphasic effect of bradykinin on rabbit afferent arterioles.
Topics: Animals; Arterioles; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; NG-Nitroarginine Methyl Ester; Rabbits; Renal Circulation; Vasodilation | 1998 |
Characterization of NPY receptors mediating contraction in rat intramyocardial coronary arteries.
Topics: Animals; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth, Vascular; Neuropeptide Y; Peptide YY; Prostaglandins; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Receptors, Thromboxane; Vasoconstriction | 1998 |
Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoforms.
Topics: Blotting, Southern; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Endothelium, Vascular; Fatty Acids, Unsaturated; Humans; Hydrazines; Intestine, Small; Protein Isoforms; Receptors, Thromboxane; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboxane A2; Thymus Gland; Trophoblasts; Tumor Cells, Cultured | 1998 |
Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats. Endothelial modulation and mechanism involved.
Topics: Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dimethyl Sulfoxide; Endothelium, Vascular; Fatty Acids, Unsaturated; Free Radical Scavengers; Hydrazines; Hydrogen Peroxide; Hypertension; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxidants; Prostaglandins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Superoxide Dismutase | 1998 |
Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.
Topics: Arachidonic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Electrophoresis, Polyacrylamide Gel; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Protein Kinase C; Receptors, Thromboxane; Thrombin; Thromboxane A2 | 1999 |
Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Cyclic GMP; Cysteine; Fatty Acids, Unsaturated; Glutathione; Guanylate Cyclase; Humans; Hydrazines; Inhibitory Concentration 50; Nitric Oxide; Nitrites; Nitroprusside; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Thromboxane A2 | 1999 |
In vivo effect of 8-epi-PGF2alpha on retinal circulation in diabetic and non-diabetic rats.
Topics: Angiography; Animals; Blood Flow Velocity; Bridged Bicyclo Compounds, Heterocyclic; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dinoprost; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Male; Phenylacetates; Prostaglandin H2; Prostaglandins H; Rats; Rats, Wistar; Regional Blood Flow; Retinal Vessels; Sulfonamides; Vasoconstrictor Agents | 1998 |
Endothelium-derived relaxing, contracting and hyperpolarizing factors of mesenteric arteries of hypertensive and normotensive rats.
Topics: Acetylcholine; Animals; Apamin; Blood Pressure; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glyburide; Hydrazines; Hypertension; In Vitro Techniques; Indomethacin; Membrane Potentials; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Nitroprusside; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Systole; Tetraethylammonium; Vasodilation; Vasodilator Agents | 1999 |
Role of endothelial factors in the specific response of mouse tumour-feeding arterioles to stimulation of 5-HT1 receptors.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Fibrosarcoma; Hydrazines; Masoprocol; Mefenamic Acid; Mice; Mice, Inbred BALB C; Nitroarginine; Oligopeptides; Phosphodiesterase Inhibitors; Phosphorylcholine; Receptors, Serotonin; Serotonin Receptor Agonists; Vasoconstrictor Agents | 1999 |
The volatile anesthetic sevoflurane mitigates cardiodepressive effects of platelets in reperfused hearts.
Topics: Adult; Anesthetics, Inhalation; Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; Lactic Acid; Male; Methyl Ethers; Myocardial Reperfusion; Platelet Adhesiveness; Platelet Membrane Glycoproteins; Sevoflurane; Thromboxane B2 | 1999 |
Thromboxane A2 contributes to the enhanced tubuloglomerular feedback activity in young SHR.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Age Factors; Animals; Blood Pressure; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; Enzyme Inhibitors; Fatty Acids, Unsaturated; Feedback; Hematocrit; Hydrazines; Imidazoles; Juxtaglomerular Apparatus; Kidney Tubules, Proximal; Loop of Henle; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Thromboxane A2; Vasoconstrictor Agents | 1999 |
Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling.
Topics: Animals; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; DNA, Complementary; Fatty Acids, Unsaturated; GTP-Binding Proteins; Hydrazines; Muscle, Smooth, Vascular; Protein Isoforms; Receptors, Thromboxane; Transfection | 1999 |
Renal vascular interaction of angiotensin II and prostaglandins in renovascular hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthesia; Angiotensin II; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Interactions; Fatty Acids, Unsaturated; Hydrazines; Hypertension, Renovascular; Indomethacin; Kidney; Perfusion; Prostaglandins; Rats; Vasoconstrictor Agents | 1999 |
Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Coronary Vasospasm; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Hydrazines; Hypoxia; In Vitro Techniques; Indomethacin; Intramolecular Oxidoreductases; Nitrates; Oxygen; Tyrosine | 1999 |
Thromboxane A2 receptor antagonism in man and rat by a sulphonylcyanoguanidine (BM-144) and a sulphonylurea (BM-500).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Male; Platelet Aggregation; Rats; Rats, Wistar; Receptors, Thromboxane; Sulfonamides; Sulfonylurea Compounds; Vasoconstriction | 1999 |
Influence of isoprostanes on vasoconstrictor effects of noradrenaline and angiotensin II.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dose-Response Relationship, Drug; Drug Interactions; Ear; F2-Isoprostanes; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Norepinephrine; Perfusion; Prostaglandins; Rabbits; Regional Blood Flow; Vasoconstriction; Vasoconstrictor Agents | 1999 |
Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Movement; Cells, Cultured; Cornea; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Endothelium, Vascular; Fatty Acids, Unsaturated; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Humans; Hydrazines; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Microcirculation; Neovascularization, Pathologic; Neovascularization, Physiologic; Prostaglandin-Endoperoxide Synthases; Renal Circulation; Tetradecanoylphorbol Acetate; Thromboxane A2 | 1999 |
Formation of PI 3-kinase products in platelets by thrombin, but not collagen, is dependent on synergistic autocrine stimulation, particularly through secreted ADP.
Topics: Adenosine Diphosphate; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Creatine Kinase; Cyproheptadine; Diterpenes; Drug Synergism; Fatty Acids, Unsaturated; Ginkgolides; Humans; Hydrazines; In Vitro Techniques; Lactones; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphocreatine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin | 1999 |
Gq/11-coupled receptors and protein synthesis in rat cardiomyocytes: role of Gi-proteins and protein kinase C-isozymes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Fatty Acids, Unsaturated; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Heart Ventricles; Hydrazines; Indoles; Inositol Phosphates; Isoenzymes; Maleimides; Norepinephrine; Pertussis Toxin; Phenylalanine; Protein Biosynthesis; Protein Kinase C; Proteins; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tritium; Virulence Factors, Bordetella | 1999 |
Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation.
Topics: Airway Resistance; Animals; Aspirin; Benzoquinones; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Chloroquine; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; In Vitro Techniques; Interleukin-6; Lipoxygenase Inhibitors; Lung; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Pulmonary Circulation; Pulmonary Edema; Quinidine; Quinine; Quinolines; Rats; Rats, Wistar; Receptors, Thromboxane; Tumor Necrosis Factor-alpha; Vascular Resistance; Vasoconstriction | 1999 |
Effect of thromboxane A2 inhibition and antagonism on prostaglandin and leukotriene synthesis in glomerular immune injury.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Antilymphocyte Serum; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Disease Models, Animal; Fatty Acids, Unsaturated; Glomerulonephritis, Membranoproliferative; Hydrazines; Kidney Glomerulus; Leukotriene B4; Macrophages; Rats; Rats, Wistar; Thromboxane A2; Thromboxane-A Synthase; Thy-1 Antigens | 1999 |
Flow reduces the amplitude and increases the frequency of lymphatic vasomotion: role of endothelial prostanoids.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Endothelium; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Lymph; Lymph Nodes; Lymphatic System; Male; Microscopy, Video; Nitroarginine; Pressure; Prostaglandins; Rats; Rats, Wistar; Receptors, Thromboxane | 1999 |
Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Chemotaxis; Dinoprost; Dinoprostone; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Unsaturated; Fibroblast Growth Factor 2; Humans; Hydrazines; Lung Neoplasms; Lymphokines; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Rats; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Local anesthetic effects on TXA2 receptor mediated platelet aggregation using quenched flow aggregometry.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Anesthetics, Local; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Bupivacaine; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Lidocaine; Platelet Aggregation; Receptors, Thromboxane; Ropivacaine; Signal Transduction; Thromboxane A2 | 1999 |
Thromboxane A2 receptor-mediated tonic contraction is attributed to an activation of phosphatidylcholine-specific phospholipase C in rabbit aortic smooth muscles.
Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cells, Cultured; Enzyme Activation; Fatty Acids, Unsaturated; Female; Hydrazines; Inhibitory Concentration 50; Isotonic Contraction; Male; Muscle, Smooth, Vascular; Norbornanes; Norepinephrine; Phorbol 12,13-Dibutyrate; Phosphatidylcholines; Phosphorylcholine; Rabbits; Receptors, Thromboxane; Signal Transduction; Thiocarbamates; Thiones; Thromboxane A2; Type C Phospholipases | 2000 |
Reactive oxygen species-induced aortic vasoconstriction and deterioration of functional integrity.
Topics: Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Flavonoids; Hydrazines; Indomethacin; Male; Methoxamine; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Potassium Chloride; Rats; Rats, Wistar; Reactive Oxygen Species; Vasoconstriction | 2000 |
Enhanced coronary vasoconstriction to oxidative stress product, 8-epi-prostaglandinF2 alpha, in experimental hypercholesterolemia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Analysis of Variance; Animals; Arginine; Arteries; Bridged Bicyclo Compounds, Heterocyclic; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Vessels; Dinoprost; Dinoprostone; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; Hypercholesterolemia; Immunohistochemistry; In Vitro Techniques; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitro Compounds; omega-N-Methylarginine; Oxidative Stress; Random Allocation; Swine; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 1999 |
Cyclooxygenase inhibitors attenuate bradykinin-induced vasoconstriction in septic isolated rat lungs.
Topics: Animals; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hypoxia; Lipopolysaccharides; Lung; Male; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Sepsis; Vasoconstriction | 2000 |
Signal-transducing mechanisms involved in activation of the platelet collagen receptor integrin alpha(2)beta(1).
Topics: Adenosine Diphosphate; Androstadienes; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Fatty Acids, Unsaturated; Hydrazines; Indoles; Integrins; Kinetics; Maleimides; Models, Biological; Peptide Fragments; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Conformation; Protein-Tyrosine Kinases; Receptors, Collagen; Signal Transduction; Thrombin; Wortmannin | 2000 |
Shear stress-induced release of prostaglandin H(2) in arterioles of hypertensive rats.
Topics: Animals; Arterioles; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Stress, Mechanical; Thromboxane-A Synthase | 2000 |
Effect of isoprostanes on sympathetic neurotransmission in the human isolated iris-ciliary body.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Aged; Bridged Bicyclo Compounds, Heterocyclic; Ciliary Body; Dinoprost; Drug Synergism; Electric Stimulation; F2-Isoprostanes; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Middle Aged; Norepinephrine; Receptors, Thromboxane; Sympathetic Nervous System; Synaptic Transmission; Vasoconstrictor Agents | 2000 |
PGH(2)-TxA(2)-receptor blockade restores vasoreactivity in a new rodent model of genetic hypertension.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cheek; Cricetinae; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Male; Nitroglycerin; Prostaglandin H2; Prostaglandins H; Thromboxane A2; Vasoactive Intestinal Peptide; Vasodilation; Vasodilator Agents; Vasomotor System | 2000 |
Aging increases PGHS-2-dependent vasoconstriction in rat mesenteric arteries.
Topics: Aging; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 2; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; In Vitro Techniques; Isoenzymes; Mesenteric Arteries; Methacholine Chloride; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstriction; Vasodilation | 2000 |
Effects of a novel non-carboxylic thromboxane A2 receptor antagonist (BM-531) derived from torasemide on platelet function.
Topics: Adenosine Diphosphate; Binding, Competitive; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hemostasis; Humans; Hydrazines; Inhibitory Concentration 50; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Sulfonamides; Sulfonylurea Compounds; Time Factors; Torsemide | 2000 |
U-46619, a selective thromboxane A2 mimetic, inhibits the release of endogenous noradrenaline from the rat hippocampus in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hippocampus; Hydrazines; Male; Norepinephrine; Potassium Chloride; Rats; Rats, Wistar; Receptors, Thromboxane | 2000 |
Characterization of prostanoid receptors mediating actions of the isoprostanes, 8-iso-PGE(2) and 8-iso-PGF(2alpha), in some isolated smooth muscle preparations.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dinoprostone; Dioxanes; Dose-Response Relationship, Drug; F2-Isoprostanes; Fatty Acids, Unsaturated; Female; Gastric Fundus; Guinea Pigs; Hydrazines; Ileum; In Vitro Techniques; Isoprostanes; Muscle Contraction; Muscle, Smooth; Oxazepines; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Thromboxane; Vasoconstriction; Vasoconstrictor Agents | 2000 |
Impaired dilation of coronary arterioles during increases in myocardial O(2) consumption with hyperglycemia.
Topics: Adrenergic beta-Agonists; Animals; Arterioles; Blood Gas Analysis; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Vessels; Diabetes Mellitus, Experimental; Dobutamine; Dogs; Endothelium, Vascular; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Hydrogen-Ion Concentration; Hyperglycemia; Myocardium; Oxygen Consumption; Perfusion; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Vasodilation; Vasodilator Agents | 2000 |
Phorbol ester-induced phosphoinositide hydrolysis in rat aorta: role of cyclooxygenase products.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Hydrolysis; Indomethacin; Inositol Phosphates; Muscle, Smooth, Vascular; Phosphatidylinositols; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate | 2000 |
Misoprostol induces relaxation of human corpus cavernosum smooth muscle: comparison to prostaglandin E1.
Topics: Alprostadil; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Hydrazines; Male; Misoprostol; Muscle Relaxation; Muscles; Penis; Receptors, Thromboxane | 2000 |
Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of AKT phosphorylation in endothelial cells by thromboxane A(2).
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angiogenesis Inhibitors; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Clone Cells; Colforsin; Cyclic AMP; Endothelium, Vascular; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Hydrazines; Isoquinolines; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Thromboxane; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Thromboxane A2; Time Factors | 2000 |
Role of altered cyclooxygenase metabolism in impaired cerebrovasodilation to nociceptin/orphanin FQ following brain injury.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blood; Blood Pressure; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Fatty Acids, Unsaturated; Female; Hydrazines; Indomethacin; Male; Nociceptin; Opioid Peptides; Pia Mater; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Superoxide Dismutase; Swine; Vasodilation | 2000 |
Changes in airway resistance by simultaneous exposure to TNF-alpha and IL-1beta in perfused rat lungs.
Topics: Airway Resistance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bronchoconstrictor Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Combinations; Fatty Acids, Unsaturated; Female; Hydrazines; In Vitro Techniques; Interleukin-1; Isoenzymes; Lung; Membrane Proteins; Methacholine Chloride; Perfusion; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Thromboxane; RNA, Messenger; Thromboxane-A Synthase; Tumor Necrosis Factor-alpha | 2001 |
L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arginine; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclic GMP; Endothelins; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydralazine; Hydrazines; Hypertension; In Vitro Techniques; Indomethacin; Male; Methacrylates; Natriuresis; Nitrates; Nitrites; Nitroprusside; Rats; Rats, Inbred Dahl; Renal Artery; Thromboxane A2; Vasoconstriction | 2001 |
Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Androstadienes; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Dinoprost; Enzyme Activation; F2-Isoprostanes; Fatty Acids, Unsaturated; Female; Fluorescent Antibody Technique, Indirect; Humans; Hydrazines; Isoquinolines; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Muscle, Smooth; Receptors, Thromboxane; Sulfonamides; Uterus; Wortmannin | 2001 |
The interaction of nitric oxide and prostaglandins in the control of corporal smooth muscle tone: evidence for production of a cyclooxygenase-derived endothelium-contracting factor.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle, Smooth; Nitric Oxide; Nitroarginine; Norepinephrine; omega-N-Methylarginine; Penis; Prostaglandins; Rabbits | 2001 |
Inhibition of prostanoid-mediated contraction to endothelin-1 after hypoxia in rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hypoxia; In Vitro Techniques; Male; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
Simulated microgravity upregulates an endothelial vasoconstrictor prostaglandin.
Topics: Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Cyclooxygenase Inhibitors; Endothelium, Vascular; Fatty Acids, Unsaturated; Hindlimb Suspension; Hydrazines; Ibuprofen; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Norepinephrine; Rats; Rats, Wistar; Receptors, Thromboxane; Time Factors; Vasoconstriction; Weightlessness Simulation | 2001 |
Identification and functional characterization of thromboxane A2 receptors in Schwann cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Fractionation; Cells, Cultured; Culture Media, Conditioned; Culture Media, Serum-Free; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Fatty Acids, Unsaturated; Humans; Hydrazines; Immunoblotting; Microscopy, Fluorescence; Radioligand Assay; Rats; Receptors, Thromboxane; Schwann Cells; Thromboxane A2; Vasoconstrictor Agents | 2001 |
Activity of a novel dual thromboxane A(2)receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth muscles.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Aorta; Arachidonic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; Inhibitory Concentration 50; Models, Chemical; Muscle, Smooth; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Thromboxane; Sulfonamides; Thromboxane-A Synthase; Torsemide; Trachea; Vasoconstrictor Agents | 2001 |
Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat.
Topics: Acetylcholine; alpha-Tocopherol; Animals; Antioxidants; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular Agents; Diet; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Flavonoids; Hydrazines; Hypertension; Indomethacin; Kaempferols; Lipid Metabolism; Nitric Oxide; Phthalic Acids; Plant Oils; Platelet Aggregation Inhibitors; Quercetin; Rats; Rats, Inbred SHR; Rutin; Umbelliferones | 2001 |
Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Dinoprost; Dinoprostone; Electric Stimulation; F2-Isoprostanes; Fatty Acids, Unsaturated; Hydrazines; Hydrogen Peroxide; Iris; Isomerism; Isoprostanes; Norepinephrine; Receptors, Thromboxane; Sympathetic Nervous System; Synaptic Transmission; Thromboxane-A Synthase; Vasoconstrictor Agents | 2001 |
Thromboxane receptor density is increased in human cardiovascular disease with evidence for inhibition at therapeutic concentrations by the AT(1) receptor antagonist losartan.
Topics: Adult; Angiotensin Receptor Antagonists; Binding, Competitive; Blood Vessels; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular Diseases; Fatty Acids, Unsaturated; Female; Heart Atria; Heart Ventricles; Humans; Hydrazines; In Vitro Techniques; Kinetics; Losartan; Male; Middle Aged; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptors, Thromboxane | 2001 |
Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production.
Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Culture Techniques; Dioxanes; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hydrogen Peroxide; Hypertension; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tachyphylaxis; Thromboxane A2; Thromboxane B2 | 2001 |
Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Catalase; Fatty Acids, Unsaturated; Hydrazines; Hyperhomocysteinemia; Male; Muscle, Skeletal; Nitric Oxide; Peroxynitrous Acid; Prostaglandins; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thromboxane A2; Vasoconstriction; Vasodilation | 2002 |
Thromboxane receptor signalling in human myometrial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Caspase 3; Caspase Inhibitors; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Myometrium; Oligopeptides; Protein Isoforms; Protein Serine-Threonine Kinases; Pyridines; Receptors, Thromboxane; rho-Associated Kinases; Signal Transduction; Type C Phospholipases | 2002 |
Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cells, Cultured; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Imidazoles; Inositol Phosphates; Kidney; Methacrylates; Phenylacetates; Platelet Activating Factor; Platelet Activation; Prostaglandin H2; Prostaglandins H; Protein Isoforms; Receptors, Thromboxane; Recombinant Fusion Proteins; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 2002 |
Involvement of protein kinase C and Na+/K+-ATPase in the contractile response induced by myricetin in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Flavonoids; Hydrazines; In Vitro Techniques; Male; Potassium Chloride; Prostaglandin H2; Prostaglandins H; Protein Kinase C; Rats; Rats, Wistar; Receptors, Prostaglandin; Receptors, Thromboxane; Sodium-Potassium-Exchanging ATPase; Staurosporine; Thromboxane A2; Vasoconstriction | 2002 |
The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Diphosphate; Anticoagulants; Arachidonic Acids; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated; Heparin; Humans; Hydrazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2002 |
Evaluation of the effects of anti-thromboxane agents in platelet-vessel wall interaction.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Communication; Dinoprost; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Methacrylates; Muscle Tonus; Muscle, Smooth, Vascular; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 2002 |
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Aging; Animals; Arginine; Arterioles; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Immunohistochemistry; In Vitro Techniques; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tyrosine; Vasodilation; Xanthine Oxidase | 2002 |
Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Bleeding Time; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Cytosol; Fatty Acids, Unsaturated; Group IV Phospholipases A2; Hydrazines; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Phospholipases A; Platelet Aggregation; Thromboembolism; Thromboxane B2 | 2002 |
Hypertension alters the participation of contractile prostanoids and superoxide anions in lipopolysaccharide effects on small mesenteric arteries.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 2; Dexamethasone; Dose-Response Relationship, Drug; Drug Combinations; Fatty Acids, Unsaturated; Hydrazines; Hypertension; In Vitro Techniques; Indomethacin; Isoenzymes; Lipopolysaccharides; Male; Mesenteric Arteries; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Thromboxane; Sulfonamides; Superoxide Dismutase; Thromboxane A2 | 2002 |
PGD(2) modulates fibroblast-mediated native collagen gel contraction.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Cells, Cultured; Collagen; Cyclic GMP; Enzyme Inhibitors; Estrenes; Fatty Acids, Unsaturated; Fibroblasts; Gels; Humans; Hydrazines; Indoles; Lung; Mesylates; Naphthalenes; Prostaglandin Antagonists; Prostaglandin D2; Protein Kinase C; Pyrroles; Pyrrolidinones; Rats; Receptors, Immunologic; Receptors, Prostaglandin; Thionucleotides; Type C Phospholipases; Wound Healing; Xanthenes; Xanthones | 2002 |
Enhanced thromboxane synthesis during chronic reductions in uterine perfusion pressure in pregnant rats.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Fatty Acids, Unsaturated; Female; Hydrazines; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Rats; Renal Circulation; Thromboxane A2; Uterus | 2002 |
The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood.
Topics: Arachidonic Acids; Benzopyrans; Bridged Bicyclo Compounds, Heterocyclic; Creatine Kinase; Cyproheptadine; Diterpenes; Enzyme Inhibitors; Escherichia coli; Fatty Acids, Unsaturated; Ginkgolides; Humans; Hydrazines; Indoles; Lactones; Lipopolysaccharides; Maleimides; Monocytes; Oligopeptides; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Thromboxane; Sulfonamides; Sulfones; Tumor Necrosis Factor-alpha | 2002 |
Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 2; Drug Administration Schedule; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; Indomethacin; Isoenzymes; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrobenzenes; Olmesartan Medoxomil; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred WKY; Renin-Angiotensin System; Sulfonamides; Superoxides; Tetrazoles; Thiazepines | 2002 |
Angiotensin II constriction of rat vasa recta is partially thromboxane dependent.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Benzofurans; Blood Vessels; Bridged Bicyclo Compounds, Heterocyclic; Culture Techniques; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; Indomethacin; Kidney Medulla; Kinetics; Lipoxygenase Inhibitors; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents | 2002 |
Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.
Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Estrogens; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; Indomethacin; Male; Ovariectomy; Phenylephrine; Progesterone; Prostaglandins; Rats; Rats, Sprague-Dawley; Sex Characteristics; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents; Vasopressins | 2002 |
Beta2 integrin-dependent neutrophil adhesion induced by minimally modified low-density lipoproteins is mainly mediated by F2-isoprostanes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; CD18 Antigens; Cell Adhesion; F2-Isoprostanes; Fatty Acids, Unsaturated; Fibrinogen; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Hydrazines; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Neutrophils; Pertussis Toxin; Receptors, Thromboxane; Signal Transduction; Ultraviolet Rays | 2002 |
Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Female; Guinea Pigs; Hydantoins; Hydrazines; Iloprost; In Vitro Techniques; Intestine, Small; Leukotriene Antagonists; Leukotriene D4; Male; Oxazepines; Peristalsis; Prostaglandin D2; Prostaglandins A; Receptors, Leukotriene; Receptors, Prostaglandin; Xanthenes; Xanthones; Yohimbine | 2002 |
Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydantoins; Hydrazines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Penis; Receptors, Immunologic; Receptors, Prostaglandin; RNA, Messenger; Vasoconstriction; Vasodilation | 2002 |
Epidermal-growth-factor receptor and metalloproteinases mediate thromboxane A2-dependent extracellular-signal-regulated kinase activation.
Topics: Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Enzyme Activation; ErbB Receptors; Fatty Acids, Unsaturated; Flavonoids; Humans; Hydrazines; Metalloendopeptidases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Thromboxane A2 | 2003 |
Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approach.
Topics: Amino Acid Sequence; Animals; Bridged Bicyclo Compounds, Heterocyclic; COS Cells; Fatty Acids, Unsaturated; Hydrazines; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Receptors, Thromboxane; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2003 |
The stable analog carbocyclic TXA2 but not platelet-released TXA2 induces osteoclast-like cell formation.
Topics: Acid Phosphatase; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Bone Marrow Cells; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cell Nucleus; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Membrane Glycoproteins; Mice; Nitrobenzenes; Osteoclasts; Prostaglandin-Endoperoxide Synthases; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Stromal Cells; Sulfonamides; Tartrates; Thromboxane A2 | 2003 |
Endothelium-derived prostaglandin H2 evokes the stretch-induced contraction of rabbit pulmonary artery.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dinoprostone; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Isometric Contraction; Methacrylates; Oligopeptides; Prostaglandin Antagonists; Prostaglandin H2; Pulmonary Artery; Rabbits; Receptors, Thromboxane A2, Prostaglandin H2; Stress, Mechanical; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasodilator Agents | 2003 |
Interaction between nitric oxide and prostanoids in arterioles of rat cremaster muscle in vivo.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Catalase; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Feedback, Physiological; Hydrazines; Male; Microcirculation; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Superoxide Dismutase | 2003 |
Solution structure of the third extracellular loop of human thromboxane A2 receptor.
Topics: Amino Acid Sequence; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Fatty Acids, Unsaturated; Humans; Hydrazines; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Peptides; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Thromboxane; Rhodopsin; Spectrometry, Fluorescence | 2003 |
The early allergic response in small airways of human precision-cut lung slices.
Topics: Acetates; Anti-Allergic Agents; Anti-Asthmatic Agents; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Cilia; Culture Techniques; Cyclopropanes; Fatty Acids, Unsaturated; Humans; Hydrazines; Hypersensitivity; Immunization, Passive; Lung; Quinolines; Reaction Time; Sulfides; Time Factors; Triprolidine | 2003 |
The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Fatty Acids, Unsaturated; Humans; Hydrazines; Interleukin-8; Lipopolysaccharides; Receptors, Thromboxane; Thromboxane A2; Tumor Necrosis Factor-alpha | 2003 |
Myogenic constriction is increased in mesenteric resistance arteries from rats with chronic heart failure: instantaneous counteraction by acute AT1 receptor blockade.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Captopril; Chronic Disease; Coronary Vessels; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Fatty Acids, Unsaturated; Heart; Heart Failure; Hydrazines; Imidazoles; Indomethacin; Lisinopril; Losartan; Male; Mesenteric Arteries; Nitric Oxide; omega-N-Methylarginine; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Superoxide Dismutase; Sympathetic Nervous System; Tetrazoles; Tetrodotoxin; Vascular Resistance | 2003 |
TRA-418, a novel compound having both thromboxane A(2) receptor antagonistic and prostaglandin I(2) receptor agonistic activities: its antiplatelet effects in human and animal platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cats; Cell Membrane; Cyclic AMP; Dogs; Epoprostenol; Fatty Acids, Unsaturated; Haplorhini; Heart Rate; Humans; Hydrazines; Inhibitory Concentration 50; Kinetics; Models, Chemical; Oxazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding; Rats; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstrictor Agents | 2003 |
Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Bridged Bicyclo Compounds, Heterocyclic; Dioxanes; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Thromboxane; Umbilical Veins; Vasoconstriction; Vasoconstrictor Agents | 2003 |
Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction: role of protein kinase Czeta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels, Voltage-Gated; Protein Kinase C; Pulmonary Artery; Rats; Rats, Wistar; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 2003 |
Synergism interaction between arachidonic acid by 5-hydroxytryptamine in human platelet aggregation is mediated through multiple signalling pathways.
Topics: Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Cyproheptadine; Diltiazem; Drug Synergism; Estrenes; Fatty Acids, Unsaturated; Humans; Hydrazines; Methysergide; Platelet Aggregation; Pyrrolidinones; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Signal Transduction; Type C Phospholipases | 2003 |
Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin.
Topics: Animals; Blood Pressure; Bradykinin B1 Receptor Antagonists; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Thromboxane A2, Prostaglandin H2; RNA, Messenger; Vasodilation | 2003 |
The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Autoradiography; Blood Platelets; Blood Proteins; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Collagen; COS Cells; Densitometry; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Isomerism; Phosphoproteins; Phosphorylation; Radioligand Assay; Receptors, Thromboxane; Stimulation, Chemical; Transfection | 2003 |
The mechanism of oxidative stress stabilization of the thromboxane receptor in COS-7 cells.
Topics: Animals; Biological Transport; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chlorocebus aethiops; Cloning, Molecular; Coronary Vessels; COS Cells; Cycloheximide; Drug Stability; Endoplasmic Reticulum; Fatty Acids, Unsaturated; Fluorescent Antibody Technique; Gene Expression; Golgi Apparatus; Green Fluorescent Proteins; Humans; Hydrazines; Hydrogen Peroxide; Kinetics; Luminescent Proteins; Muscle, Smooth, Vascular; Oxidative Stress; Protein Isoforms; Receptors, Thromboxane A2, Prostaglandin H2; Recombinant Fusion Proteins; Transfection; Tritium | 2004 |
11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Basophils; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Carbazoles; Cell Size; Chemotaxis, Leukocyte; Enzyme Inhibitors; Eosinophils; Fatty Acids, Unsaturated; Flow Cytometry; Humans; Hydrazines; Pertussis Toxin; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Thromboxane B2; Transfection; Type C Phospholipases | 2004 |
Vascular oxygen sensing: detection of novel candidates by proteomics and organ culture.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Fatty Acids, Unsaturated; Hydrazines; Hypoxia; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Organ Culture Techniques; Oxygen; Proteomics; rho GTP-Binding Proteins; Swine; Tropomyosin; Vasoconstrictor Agents | 2004 |
Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Movement; Endocytosis; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Unsaturated; Fibroblast Growth Factor 2; Humans; Hydrazines; Inflammation; Integrin alphaVbeta3; Ischemia; Ligands; Neovascularization, Physiologic; Protein Isoforms; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Receptors, Thromboxane A2, Prostaglandin H2; Thrombospondin 1; Thromboxane A2; Transcription, Genetic; Tumor Suppressor Protein p53 | 2004 |
Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries.
Topics: Animals; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Arteries; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Isoenzymes; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Sulfonamides; Vasodilation | 2004 |
Restoration of blood pressure by centrally injected U-46619, a thromboxane A(2) analog, in hemorrhaged hypotensive rats: investigation of different brain areas.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-1 Receptor Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Antidiuretic Hormone Receptor Antagonists; Blood Pressure; Brain; Bridged Bicyclo Compounds, Heterocyclic; Catecholamines; Fatty Acids, Unsaturated; Heart Rate; Hemodynamics; Hemorrhage; Hydrazines; Hypotension; Injections; Injections, Intraventricular; Male; Medulla Oblongata; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Renin; Shock, Hemorrhagic; Solitary Nucleus; Thromboxane A2; Vasoconstrictor Agents; Vasopressins | 2004 |
Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates.
Topics: Animals; Binding Sites; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cloprostenol; Cricetinae; Dinoprost; Dinoprostone; Enprostil; Epoprostenol; Fatty Acids, Unsaturated; Female; Hydantoins; Hydrazines; Iloprost; Latanoprost; Misoprostol; Prostaglandins; Prostaglandins E, Synthetic; Prostaglandins F, Synthetic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Tritium; Uterus | 2004 |
Cyclooxygenase involvement in thromboxane-dependent contraction in rat mesenteric resistance arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Endothelin-1; Fatty Acids, Unsaturated; Flurbiprofen; Hydrazines; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mesenteric Arteries; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred WKY; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; Thromboxane A2; Vascular Resistance; Vasoconstriction | 2004 |
Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; Cell Movement; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Unsaturated; Focal Adhesions; Humans; Hydrazines; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Donors; Phosphorylation; Protein Isoforms; Protein Kinases; Protein Processing, Post-Translational; Rats; Receptors, Thromboxane A2, Prostaglandin H2; Recombinant Proteins; Signal Transduction; Transfection; Umbilical Veins; Vascular Endothelial Growth Factor A | 2004 |
Arachidonic acid metabolites and peroxide-induced inhibition of [3H]D-aspartate release from bovine isolated retinae.
Topics: Animals; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cyclooxygenase Inhibitors; D-Aspartic Acid; Dinoprost; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Unsaturated; Flurbiprofen; Hydrazines; Hydrogen Peroxide; Potassium Chloride; Receptors, Thromboxane; Retina | 2004 |
In-vitro contraction of the equine aortic valve.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Aortic Valve; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelin-1; Fatty Acids, Unsaturated; Free Radical Scavengers; Horses; Hydrazines; Medetomidine; Models, Animal; Models, Cardiovascular; Myocardial Contraction; Norepinephrine; Phenylephrine; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Serotonin; Statistics as Topic; Vasoconstrictor Agents | 2004 |
Effect of the statin atorvastatin on intracellular signalling by the prostacyclin receptor in vitro and in vivo.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenylyl Cyclases; Animals; Atorvastatin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Cell Line, Tumor; Cholesterol; Clinical Trials as Topic; Cyclic AMP; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated; Female; Heptanoic Acids; Humans; Hydantoins; Hydrazines; Iloprost; Ireland; Lipids; Male; Mice; Middle Aged; Propanolamines; Protein Prenylation; Pyrroles; Radioligand Assay; Receptor Cross-Talk; Receptors, Epoprostenol; Receptors, Immunologic; Receptors, Prostaglandin; Signal Transduction; Tritium | 2004 |
Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dinoprostone; Dioxanes; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; In Vitro Techniques; Isoprostanes; Receptors, Thromboxane; Umbilical Veins; Vasoconstrictor Agents | 2004 |
Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Binding Sites; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Epitopes; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Immunoblotting; Immunoprecipitation; Inositol Phosphates; Isoprostanes; Ligands; Mice; Muscle, Smooth; Platelet Aggregation; Protein Binding; Radioimmunoassay; Receptors, Epoprostenol; Receptors, Thromboxane; Signal Transduction; Time Factors; Transfection | 2004 |
The isoprostane 8-iso-PGF2alpha suppresses monocyte adhesion to human microvascular endothelial cells via two independent mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Adhesion; Cell Line; Culture Media, Conditioned; Dinoprost; Dose-Response Relationship, Drug; Endothelial Cells; Fatty Acids, Unsaturated; Humans; Hydrazines; Inflammation; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Kidney; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; Rats; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Skin; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2005 |
Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Endothelin-1; Endotoxemia; Fatty Acids, Unsaturated; Gadolinium; Hydrazines; Kupffer Cells; Lipopolysaccharides; Liver; Male; Portal Pressure; Portal System; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 2005 |
Testosterone treatment increases thromboxane function in rat cerebral arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Androgens; Animals; Benzofurans; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Male; Middle Cerebral Artery; Orchiectomy; Rats; Rats, Inbred F344; Receptors, Thromboxane; Testosterone; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2005 |
Differential effects of 20-hydroxyeicosatetraenoic acid on intrarenal blood flow in the rat.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebrovascular Circulation; Dinoprostone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Hydroxyeicosatetraenoic Acids; Indomethacin; Kidney Medulla; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasoconstriction | 2005 |
Gender difference in response to thromboxane A2/prostaglandin H2 receptor antagonism in spontaneously hypertensive rats.
Topics: Analysis of Variance; Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Male; Rats; Rats, Inbred SHR; Sex Factors; Thromboxane-A Synthase | 2004 |
Implications for repetitive application of acetylcholine in the determination of the mechanisms of endothelium-dependent relaxation.
Topics: Acetylcholine; Animals; Apamin; Barium; Bridged Bicyclo Compounds, Heterocyclic; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Femoral Artery; Hydrazines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Nitroarginine; Norepinephrine; Potassium; Rats; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
The involvement of central cholinergic system in the pressor effect of intracerebroventricularly injected U-46619, a thromboxane A2 analog, in conscious normotensive rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Central Nervous System; Choline; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Hypothalamus, Posterior; Injections, Intraventricular; Male; Mecamylamine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Thromboxane A2, Prostaglandin H2; Time Factors; Vasoconstrictor Agents | 2005 |
Nitric oxide modulates angiotensin II-induced endothelial vasoconstrictor prostanoid release.
Topics: Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Ascorbic Acid; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Potassium Channel Blockers; Prostaglandins; Rabbits; Receptors, Thromboxane; Tetraethylammonium; Vasoconstriction; Vasomotor System | 2005 |
Altered arachidonic acid metabolism impairs functional vasodilation in metabolic syndrome.
Topics: Animals; Arachidonic Acid; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Iloprost; Metabolic Syndrome; Muscle, Skeletal; Nitroprusside; Obesity; Rats; Rats, Zucker; Vasodilation; Vasodilator Agents | 2006 |
Hydrogen peroxide is an endothelium-dependent contracting factor in rat renal artery.
Topics: Acetylcholine; Animals; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Catalase; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hydrogen Peroxide; In Vitro Techniques; Male; Muscle, Smooth, Vascular; NADPH Oxidases; Nitric Oxide Synthase; Nitroarginine; Onium Compounds; Rats; Rats, Inbred WKY; Receptors, Thromboxane A2, Prostaglandin H2; Renal Artery; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents | 2005 |
CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Carbazoles; Cell Line; Cell Movement; Cyclic AMP; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Hydrazines; Indomethacin; Models, Biological; Pentanoic Acids; Prostaglandin D2; Pyridines; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Transfection; Tritium | 2005 |
Involvement of thromboxane receptor in the proatherogenic effect of isoprostane F2alpha-III: evidence from apolipoprotein E- and LDL receptor-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Humans; Hydrazines; Isoprostanes; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL; Receptors, Thromboxane | 2005 |
Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells.
Topics: Base Sequence; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Cells, Cultured; Cytokines; DNA; Fatty Acids, Unsaturated; Humans; Hydantoins; Hydrazines; Inflammation; Inflammation Mediators; Interleukin-13; Interleukin-4; Interleukin-5; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Th2 Cells; Up-Regulation | 2005 |
Vasoactive responses of U46619, PGF2alpha, latanoprost, and travoprost in isolated porcine ciliary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Ciliary Arteries; Cloprostenol; Dinoprost; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Latanoprost; Prostaglandins F, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Swine; Travoprost; Vasoconstriction; Vasoconstrictor Agents | 2006 |
PAR-2 activating peptide-induced stimulation of pregnant rat myometrium contractile activity partly involves the other membrane receptors.
Topics: Animals; Atropine; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hydrazines; Ibuprofen; In Vitro Techniques; Ketanserin; Ketotifen; Metabolic Networks and Pathways; Myometrium; Oligopeptides; Platelet Membrane Glycoproteins; Pregnancy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptors, G-Protein-Coupled; Receptors, Histamine H1; Receptors, Serotonin; Receptors, Thromboxane A2, Prostaglandin H2; Uterine Contraction | 2007 |
The G12 family of G proteins as a reporter of thromboxane A2 receptor activity.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Dinoprost; Electrophoresis, Polyacrylamide Gel; Fatty Acids, Unsaturated; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Hydrazines; Radioligand Assay; Receptors, Thromboxane A2, Prostaglandin H2; Spodoptera | 2006 |
Contribution of prostanoid tp receptors to the pressor and intrarenal haemodynamic response to endothelin.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Endothelin B Receptor Antagonists; Endothelins; Fatty Acids, Unsaturated; Hydrazines; Infusions, Intravenous; Laser-Doppler Flowmetry; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Renal Circulation | 2006 |
The role of the central thromboxane A2 in cardiovascular effects of a phospholipase A2 activator melittin administrated intracerebroventricularly in normotensive conscious rats.
Topics: Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Male; Melitten; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 2006 |
Physiological significance of thromboxane A(2) receptor dimerization.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alternative Splicing; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dimerization; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Green Fluorescent Proteins; Humans; Hydrazines; Microscopy, Confocal; Oligopeptides; Peptides; Protein Isoforms; Receptors, Thromboxane A2, Prostaglandin H2; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2006 |
Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents.
Topics: Angiogenesis Inhibitors; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Adhesion; Cell Movement; Cells, Cultured; Cyclooxygenase Inhibitors; Endothelial Cells; Fatty Acids, Unsaturated; Humans; Hydrazines; Male; Platelet Aggregation; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Torsemide | 2006 |
Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity.
Topics: Alprostadil; Bridged Bicyclo Compounds, Heterocyclic; Diabetes Mellitus; Endothelium; Erectile Dysfunction; Fatty Acids, Unsaturated; Humans; Hydrazines; Indoles; Male; Maleimides; Middle Aged; Muscle Relaxation; Penis; Protein Kinase C; Receptors, Thromboxane | 2006 |
Activation of the central cholinergic system mediates the reversal of hypotension by centrally administrated U-46619, a thromboxane A2 analog, in hemorrhaged rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Fibers; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Fluid; Fatty Acids, Unsaturated; Hemorrhage; Hydrazines; Hypotension; Hypothalamus, Posterior; Injections, Intraventricular; Male; Neural Pathways; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Time Factors; Vasoconstrictor Agents | 2006 |
Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells: role of receptor heterodimerization.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cells, Cultured; Dimerization; Endocytosis; Epoprostenol; Fatty Acids, Unsaturated; Gene Expression Regulation; Humans; Hydrazines; Iloprost; Mice; Muscle, Smooth, Vascular; Protein Transport; Receptors, Epoprostenol; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thromboxane A2; Transfection | 2007 |
Distinct effects of z-335, a new thromboxane A2 receptor antagonist, on rabbit platelets and aortic smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Animals; Aorta, Thoracic; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Shape; Cells, Cultured; Dose-Response Relationship, Drug; Endothelins; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indans; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Norepinephrine; Platelet Aggregation; Rabbits; Radioligand Assay; Receptors, Thromboxane A2, Prostaglandin H2; Tritium; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Direct vasoconstrictor effect of prostaglandin E2 on renal interlobular arteries: role of the EP3 receptor.
Topics: Angiotensin II; Animals; Arteries; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hydronephrosis; In Vitro Techniques; Kidney Cortex; Male; Muscle, Smooth, Vascular; Norepinephrine; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Thromboxane A2, Prostaglandin H2; Renal Circulation; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Enantiomeric metabolic interactions and stereoselective human methadone metabolism.
Topics: Algorithms; Aryl Hydrocarbon Hydroxylases; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydrazines; Kinetics; Methadone; Mixed Function Oxygenases; Narcotics; Nitrobenzenes; Oxidoreductases, N-Demethylating; Rifampin; Stereoisomerism; Sulfonamides; Superoxides; Thiobarbituric Acid Reactive Substances | 2007 |
Potentiation of adrenaline vasoconstrictor response by sub-threshold concentrations of U-46619 in human umbilical vein: involvement of smooth muscle prostanoid TP(alpha) receptor isoform.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Epinephrine; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Muscle, Smooth, Vascular; Protein Isoforms; Receptors, Thromboxane; Reverse Transcriptase Polymerase Chain Reaction; Umbilical Veins; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Functional characterization of the mechanisms underlying bradykinin-induced relaxation in the isolated rat carotid artery.
Topics: Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Imines; In Vitro Techniques; Indazoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptor, Bradykinin B2; Vasodilation; Xanthones | 2007 |
Short-term ANG II produces renal vasoconstriction independent of TP receptor activation and TxA2/isoprostane production.
Topics: Angiotensin II; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Fatty Acids, Unsaturated; Hydrazines; Isoprostanes; Male; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Renal Circulation; Thromboxane A2; Time Factors; Vasoconstriction | 2007 |
Inhibitory effect of ethanol extract of Piper longum L. on rabbit platelet aggregation through antagonizing thromboxane A2 receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Dioxolanes; Fatty Acids, Unsaturated; Hydrazines; Male; Phosphatidylinositols; Piper; Piperidines; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Polyunsaturated Alkamides; Rabbits; Receptors, Thromboxane A2, Prostaglandin H2 | 2007 |
Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dioxolanes; Fatty Acids, Unsaturated; Heterocyclic Compounds, 1-Ring; Hydrazines; Male; Phosphatidylinositols; Piper; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Thromboxane A2, Prostaglandin H2 | 2007 |
BM-520, an original TXA2 modulator, inhibits the action of thromboxane A2 and 8-iso-prostaglandin F2alphain vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Diphenylamine; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; Male; Models, Chemical; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Sulfonylurea Compounds; Thromboxane A2 | 2007 |
A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice.
Topics: Acetylcholine; Acetylcysteine; Aging; Animals; Antioxidants; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Catechin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation, Enzymologic; Hydrazines; Indomethacin; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Oxidation-Reduction; Reactive Oxygen Species; Receptors, Thromboxane A2, Prostaglandin H2; Renal Artery; RNA, Messenger; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasodilator Agents | 2007 |
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
Topics: Animals; Arachidonate 5-Lipoxygenase; Betamethasone Valerate; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Chromones; Cimetidine; Culicidae; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Hydroxyurea; Hypersensitivity; Indoles; Indomethacin; Ketoprofen; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Phenylpropionates; Phospholipid Ethers; Propionates; Pruritus; Quinolines; Terfenadine | 2007 |
Up-regulated thromboxane production in the rat liver with biliary obstruction does not contribute to promote hepatic injury.
Topics: Alanine Transaminase; Animals; Bilirubin; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation, Enzymologic; Hyaluronic Acid; Hydrazines; Liver; Liver Diseases; Male; Methacrylates; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Time Factors | 2008 |
Orchidectomy increases the formation of prostanoids and modulates their role in the acetylcholine-induced relaxation in the rat aorta.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 2; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Male; Orchiectomy; Prostaglandins; Rats; Rats, Sprague-Dawley; Testosterone; Thromboxane A2; Vasodilation | 2008 |
The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Immunohistochemistry; Naphthalenes; Phenylephrine; Potassium Chloride; Propionates; Prostaglandin Antagonists; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Thromboxane; Sulfonamides; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Xanthones | 2008 |
F2-isoprostane receptors on hepatic stellate cells.
Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Collagen; Dinoprost; DNA; F2-Isoprostanes; Fatty Acids, Unsaturated; Humans; Hydrazines; Liver; Pericytes; Receptors, Thromboxane A2, Prostaglandin H2; Tritium; Vasoconstrictor Agents | 2008 |
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydrazines; Ligands; Male; Prostatic Neoplasms; Pyridines; Receptors, Thromboxane A2, Prostaglandin H2; rhoA GTP-Binding Protein | 2008 |
Alpha-adrenoceptor-mediated vasoconstriction is not involved in impaired functional vasodilation in the obese Zucker rat.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Male; Muscle, Skeletal; Obesity; Phenylephrine; Rats; Rats, Zucker; Receptors, Adrenergic, alpha; Vasoconstriction; Vasodilation | 2008 |
TP receptor as a therapeutic target in atherosclerosis and related cardiovascular diseases.
Topics: Animals; Atherosclerosis; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular Diseases; Fatty Acids, Unsaturated; Humans; Hydrazines; Lipoxygenase Inhibitors; Naphthalenes; Oxidative Stress; Propionates; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction | 2006 |
Insulin resistance and impaired functional vasodilation in obese Zucker rats.
Topics: Animals; Antioxidants; Arachidonic Acid; Arterioles; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Cyclic N-Oxides; Disease Models, Animal; Electric Stimulation; Fatty Acids, Unsaturated; Hydrazines; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Resistance; Kidney Cortex; Male; Muscle, Skeletal; NADPH Oxidases; Obesity; Oxidative Stress; Rats; Rats, Zucker; Receptors, Thromboxane; Rosiglitazone; Spin Labels; Superoxides; Thiazolidinediones; Thromboxanes; Time Factors; Triglycerides; Vasoconstriction; Vasodilation | 2008 |
Increased myogenic responsiveness of skeletal muscle arterioles with juvenile growth.
Topics: Acetylcholine; Age Factors; Animals; Arterioles; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heme Oxygenase (Decyclizing); Hydrazines; Male; Mesoporphyrins; Muscle Development; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitroprusside; Phenylephrine; Prostaglandin H2; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Regional Blood Flow; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2008 |
Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway.
Topics: Apigenin; Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Endothelium; Fatty Acids, Unsaturated; Humans; Hydrazines; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Receptors, Thromboxane A2, Prostaglandin H2; Thrombosis | 2008 |
Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation.
Topics: Actins; Adenosine Diphosphate; Antibodies, Monoclonal; Autocrine Communication; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane; Fatty Acids, Unsaturated; Glycerophospholipids; Humans; Hydrazines; Isoenzymes; Lysosomes; Oligopeptides; Phospholipase D; Platelet Activation; Platelet Aggregation Inhibitors; Thrombin | 2008 |
Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Unsaturated; Free Radical Scavengers; Hydrazines; Hypoxia; Imidazoles; Indomethacin; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Obesity; Oxidative Stress; Polyethylene Glycols; Rats; Rats, Zucker; Receptors, Thromboxane; Superoxide Dismutase; Thromboxane A2; Thromboxane-A Synthase; Up-Regulation; Vasodilation | 2008 |
Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus.
Topics: Age Factors; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Cyclic AMP; Dinoprostone; Ductus Arteriosus; Fatty Acids, Unsaturated; Hydrazines; Isoproterenol; Milrinone; Muscle Contraction; Xanthones | 2009 |
Equol is more active than soy isoflavone itself to compete for binding to thromboxane A(2) receptor in human platelets.
Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Equol; Fatty Acids, Unsaturated; Genistein; Humans; Hydrazines; Isoflavones; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane A2, Prostaglandin H2 | 2009 |
Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between ox
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Actins; Angiogenesis Inhibitors; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Movement; Cells, Cultured; Chick Embryo; Chorioallantoic Membrane; Coronary Vessels; Dinoprost; Dinoprostone; Dioxanes; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Unsaturated; Focal Adhesion Kinase 1; Humans; Hydrazines; Isoprostanes; Mice; Neovascularization, Physiologic; Oxidative Stress; Phosphorylation; Prostaglandins A; Proto-Oncogene Proteins c-akt; Receptors, Thromboxane A2, Prostaglandin H2; RNA Interference; RNA, Small Interfering; Stress Fibers; Sulfonylurea Compounds; Tissue Culture Techniques; Vascular Endothelial Growth Factor A | 2008 |
The Gq and G12 families of heterotrimeric G proteins report functional selectivity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Bicyclic Monoterpenes; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Cell Shape; Cytosol; Dinoprost; Fatty Acids, Unsaturated; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrazines; Inhibitory Concentration 50; Kidney; Ligands; Molecular Conformation; Platelet Aggregation; Radioligand Assay; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 2009 |
Cyclooxygenase 2 inhibition suppresses tubuloglomerular feedback: roles of thromboxane receptors and nitric oxide.
Topics: Animals; Arginine; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Feedback, Physiological; Hydrazines; Isoxazoles; Kidney Glomerulus; Kidney Tubules; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction | 2009 |
Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2.
Topics: Animals; Blood Flow Velocity; Blood Viscosity; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Male; Methacrylates; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin H2; Rats; Rats, Wistar; Regional Blood Flow; Stress, Mechanical; Thromboxane A2; Venules | 2009 |
Thromboxane A2 receptor antagonism by flavonoids: structure-activity relationships.
Topics: Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Flavonoids; Humans; Hydrazines; Receptors, Thromboxane A2, Prostaglandin H2; Structure-Activity Relationship; Tritium | 2009 |
Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats.
Topics: Acetophenones; Acetylcholine; Animals; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Fatty Acids, Unsaturated; Guanylate Cyclase; Hydrazines; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Pyrazoles; Pyridines; Rats; Rats, Inbred SHR; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxide Dismutase; Vasodilation; Vasodilator Agents | 2009 |
Involvement of the thromboxane A2 receptor in the regulation of steroidogenic acute regulatory gene expression in murine Leydig cells.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cyclooxygenase 2; Fatty Acids, Unsaturated; Gene Expression Regulation; Hydrazines; Leydig Cells; Male; Mice; Phosphoproteins; Rats; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonylurea Compounds; Thromboxane A2; Thromboxane-A Synthase | 2009 |
The effect of endothelin-1 on the production of interleukin-6 in cultured human detrusor smooth muscle cells, and the effect of interleukin-6 on the contractile response of bladder smooth muscle strips from rats.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cyclooxygenase Inhibitors; Cystitis; Dose-Response Relationship, Drug; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Unsaturated; Humans; Hydrazines; Indomethacin; Interleukin-6; Muscle Contraction; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder | 2009 |
Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.
Topics: Animals; Benzofurans; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cyclooxygenase Inhibitors; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Fatty Acids, Unsaturated; Flurbiprofen; Glutamic Acid; Glutamine; Glycine; Hydrazines; Isoprostanes; Neurotransmitter Agents; Nitrobenzenes; Prostaglandins; Receptors, Prostaglandin; Retina; Sulfonamides; Xanthones | 2009 |
Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta.
Topics: Acetylcholine; Animals; Aorta; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Fatty Acids, Unsaturated; Female; Hydrazines; Intramolecular Oxidoreductases; Membrane Proteins; Nitric Oxide; Nitrobenzenes; Ovariectomy; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Tranylcypromine; Vasodilation; Vasodilator Agents | 2009 |
Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.
Topics: Acetylcholine; Age Factors; Aging; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Hypertension; Indomethacin; Male; Membrane Proteins; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Epoprostenol; Receptors, Thromboxane A2, Prostaglandin H2; Sex Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2009 |
Inhibition of thromboxane A2-induced arrhythmias and intracellular calcium changes in cardiac myocytes by blockade of the inositol trisphosphate pathway.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arrhythmias, Cardiac; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Fatty Acids, Unsaturated; Heart Atria; Heart Ventricles; Hydrazines; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Myocytes, Cardiac; Rabbits; Receptors, Thromboxane A2, Prostaglandin H2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thromboxane A2; Vasoconstrictor Agents | 2009 |
Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; ErbB Receptors; Extracellular Fluid; Fatty Acids, Unsaturated; Humans; Hydrazines; Intracellular Fluid; Isoenzymes; Ligands; PC12 Cells; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Receptors, Thromboxane A2, Prostaglandin H2; Transcriptional Activation; Tumor Cells, Cultured | 2009 |
A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adolescent; Amino Acid Motifs; Amino Acid Substitution; Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; CHO Cells; Cricetinae; Cricetulus; Cytosol; Fatty Acids, Unsaturated; Female; Gene Expression; Hemorrhagic Disorders; Humans; Hydrazines; Ligands; Male; Mutation, Missense; Protein Binding; Protein Structure, Tertiary; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstrictor Agents | 2010 |
Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A(2) receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Binding Sites; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cyclic AMP; Fatty Acids, Unsaturated; Glyburide; Humans; Hydrazines; Platelet Aggregation Inhibitors; Receptors, Thromboxane A2, Prostaglandin H2; Scintillation Counting; Spectrometry, Fluorescence | 2010 |
TRA-418, a thromboxane A2 receptor antagonist and prostacyclin receptor agonist, inhibits platelet-leukocyte interaction in human whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Communication; Cell Separation; Cells, Cultured; Epinephrine; Epoprostenol; Fatty Acids, Unsaturated; Flow Cytometry; Humans; Hydrazines; Leukocytes; Oxazines; Peptide Fragments; Platelet Activation; Receptors, Epoprostenol; Receptors, Thromboxane A2, Prostaglandin H2; Thrombosis | 2010 |
4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinogens; Cell Growth Processes; Cell Survival; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Unsaturated; Humans; Hydrazines; Lung Neoplasms; Nitrosamines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Thromboxane A2, Prostaglandin H2; Smoking; Thromboxane A2; Thromboxane-A Synthase; Tumor Cells, Cultured | 2011 |
Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Enzyme Activation; Fatty Acids, Unsaturated; GTP-Binding Proteins; Humans; Hydrazines; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstriction; Vasoconstrictor Agents | 2010 |
Divergence between arterial perfusion and fatigue resistance in skeletal muscle in the metabolic syndrome.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antioxidants; Arteries; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hyperemia; Hypertension; In Vitro Techniques; Male; Metabolic Syndrome; Methacholine Chloride; Muscle Fatigue; Muscle, Skeletal; Obesity; Oxygen; Perfusion; Peripheral Vascular Diseases; Phenylephrine; Rats; Rats, Zucker; Vasoconstriction | 2011 |
Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid.
Topics: Animals; Arachidonic Acid; Benzofurans; Blood Pressure; Bradycardia; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular System; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Indomethacin; Infusions, Intraventricular; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thromboxane A2 | 2011 |
Resistance artery mechanics and composition in angiotensin II-infused mice: effects of cyclooxygenase-1 inhibition.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Angiotensin II; Animals; Biomechanical Phenomena; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Collagen Type I; Coronary Vessels; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprost; Elastin; Fatty Acids, Unsaturated; Fibronectins; Humans; Hydrazines; Immunohistochemistry; Male; Mesenteric Arteries; Mice; Mice, Knockout; Pyrazoles; Vascular Resistance | 2012 |
EP4 receptor as a new target for bronchodilator therapy.
Topics: Alprostadil; Animals; Asthma; Bridged Bicyclo Compounds, Heterocyclic; Bronchodilator Agents; Dinoprostone; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; Macaca fascicularis; Methyl Ethers; Mice; Mice, Inbred C57BL; Naphthalenes; Phenylbutyrates; Prostanoic Acids; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Regression Analysis; Species Specificity; Trachea; Xanthones | 2011 |
Improved functional vasodilation in obese Zucker rats following exercise training.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Blood Glucose; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Eating; Electric Stimulation; Exercise Therapy; Fatty Acids, Unsaturated; Glucose Tolerance Test; Hydrazines; Insulin Resistance; Male; Muscle, Skeletal; Obesity, Morbid; Oxygen Consumption; Rats; Rats, Zucker; Receptors, Thromboxane; Recovery of Function; Time Factors; Vasoconstriction; Vasodilation | 2011 |
Computational analyses of intravascular tracer washout reveal altered capillary-level flow distributions in obese Zucker rats.
Topics: Albumins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; Computer Simulation; Cyclic N-Oxides; Disease Models, Animal; Endovascular Procedures; Fatty Acids, Unsaturated; Hydrazines; Iodine Radioisotopes; Male; Models, Animal; Models, Biological; Muscle, Skeletal; Obesity; Phentolamine; Rats; Rats, Zucker; Regional Blood Flow; Spin Labels | 2011 |
Effects of pioglitazone and rosiglitazone on vascular function of mesenteric resistance arteries in rat genetic hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelium, Vascular; Epinephrine; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Hypoglycemic Agents; Indomethacin; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Pioglitazone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rosiglitazone; Thiazolidinediones; Thromboxane A2; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 2011 |
Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Dioxanes; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; In Vitro Techniques; Isoprostanes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Perfusion; Placenta; Pregnancy; Prostaglandins; Receptors, Prostaglandin E; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxanes; Xanthones | 2011 |
Site-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alanine; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Chlorocebus aethiops; COS Cells; Fatty Acids, Unsaturated; Glycine; HEK293 Cells; Humans; Hydrazines; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Mutation, Missense; Polymorphism, Single Nucleotide; Protein Structure, Secondary; Radioligand Assay; Receptors, Thromboxane A2, Prostaglandin H2; Structure-Activity Relationship; Temperature | 2012 |
Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dinoprostone; Ductus Arteriosus; Ductus Arteriosus, Patent; Fatty Acids, Unsaturated; Female; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Hydrazines; Isoprostanes; Mice; Myography; Oxidative Stress; Oxygen; Pregnancy; Premature Birth; Receptors, Prostaglandin E, EP4 Subtype; Receptors, Thromboxane A2, Prostaglandin H2; Vasodilation | 2012 |
Antioxidants condition pleiotropic vascular responses to exogenous H(2)O(2): role of modulation of vascular TP receptors and the heme oxygenase system.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antioxidants; Base Sequence; Blood Vessels; Bridged Bicyclo Compounds, Heterocyclic; DNA Primers; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heme Oxygenase (Decyclizing); Hydrazines; Hydrogen Peroxide; Imidazoles; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane | 2013 |
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Oligonucleotide Array Sequence Analysis; Placenta; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley | 2012 |
Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Blood Platelets; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Chromatography, High Pressure Liquid; Endothelium, Vascular; Fatty Acids, Unsaturated; HEK293 Cells; Humans; Hydrazines; Isometric Contraction; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstrictor Agents; Vasodilator Agents | 2013 |
Blunted temporal activity of microvascular perfusion heterogeneity in metabolic syndrome: a new attractor for peripheral vascular disease?
Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cyclic N-Oxides; Disease Models, Animal; Fatty Acids, Unsaturated; Humans; Hydrazines; Male; Metabolic Syndrome; Microvessels; Muscle, Skeletal; Obesity; Oxidative Stress; Peripheral Vascular Diseases; Phentolamine; Rats; Rats, Zucker; Spin Labels | 2013 |
Platelet dysfunction associated with the novel Trp29Cys thromboxane A₂ receptor variant.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Coagulation Disorders; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Unsaturated; Genetic Predisposition to Disease; Genetic Variation; HEK293 Cells; Humans; Hydrazines; Ligands; Male; Microscopy, Fluorescence; Middle Aged; Phenotype; Platelet Aggregation; Radioligand Assay; Receptors, Thromboxane A2, Prostaglandin H2; Transfection | 2013 |
Hydrogen peroxide via thromboxane A2 receptors mediates myogenic response of small skeletal muscle veins in rats.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; Muscle, Skeletal; Pressure; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Veins | 2013 |
Thromboxane A2 exerts promoting effects on cell proliferation through mediating cyclooxygenase-2 signal in lung adenocarcinoma cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Benzofurans; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Unsaturated; Flow Cytometry; Humans; Hydrazines; Immunoenzyme Techniques; Lung Neoplasms; Nitrobenzenes; Real-Time Polymerase Chain Reaction; Receptors, Thromboxane; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Sulfonylurea Compounds; Thromboxane A2; Thromboxane-A Synthase | 2014 |
Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor.
Topics: Amino Acid Substitution; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Carbazoles; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated; HEK293 Cells; Humans; Hydrazines; Inositol 1,4,5-Trisphosphate; Mutagenesis, Site-Directed; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides | 2014 |
Prenatal exposure to hyperoxia modifies the thromboxane prostanoid receptor-mediated response to H2O2 in the ductus arteriosus of the chicken embryo.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Cyclooxygenase Inhibitors; Ductus Arteriosus; Fatty Acids, Unsaturated; Hydrazines; Hydrogen Peroxide; Hyperoxia; Indomethacin; Receptors, Thromboxane; Vasoconstriction; Vasodilation | 2014 |
Impact of increased intramuscular perfusion heterogeneity on skeletal muscle microvascular hematocrit in the metabolic syndrome.
Topics: Animals; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Cyclic N-Oxides; Fatty Acids, Unsaturated; Hematocrit; Hydrazines; Metabolic Syndrome; Microcirculation; Muscle, Skeletal; Rats; Receptors, Thromboxane A2, Prostaglandin H2; Spin Labels | 2014 |
Novel inhibitory effects of cardamonin on thromboxane A2-induced scratching response: Blocking of Gh/transglutaminase-2 binding to thromboxane A2 receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Behavior, Animal; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chalcones; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; GTP-Binding Proteins; Humans; Hydrazines; Mice; Protein Binding; Protein Glutamine gamma Glutamyltransferase 2; Pruritus; Radioligand Assay; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Transglutaminases; Tritium | 2014 |
Acute restraint stress induces endothelial dysfunction: role of vasoconstrictor prostanoids and oxidative stress.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Endothelium, Vascular; Fatty Acids, Unsaturated; Glutathione; Hydrazines; Hydrogen Peroxide; Indomethacin; Male; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Phenylephrine; Prostaglandins; Rats; Rats, Wistar; Restraint, Physical; Serotonin; Stress, Psychological; Thiobarbituric Acid Reactive Substances; Thromboxane B2; Vasoconstrictor Agents | 2015 |
Brain changes associated with thromboxane receptor antagonist SQ 29,548 treatment in a mouse model.
Topics: Animals; Anxiety; Brain; Bridged Bicyclo Compounds, Heterocyclic; Depression; Disease Models, Animal; Fatty Acids, Unsaturated; Hydrazines; Male; Mice; Mice, Inbred C57BL; Receptors, Thromboxane; Treatment Outcome | 2015 |
Receptors involved in the modulation of guinea pig urinary bladder motility by prostaglandin D2.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Guinea Pigs; Hydantoins; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Prostaglandin D2; Receptors, Prostaglandin; Receptors, Thromboxane; Urinary Bladder | 2015 |
Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Asthma; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Bronchoconstriction; Cells, Cultured; Dinoprost; Dinoprostone; Fatty Acids, Unsaturated; Histamine; Humans; Hydrazines; Immunoglobulin E; In Vitro Techniques; Mast Cells; Molecular Targeted Therapy; Naphthalenes; Phenylbutyrates; Prostaglandin D2; Receptors, Prostaglandin; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Receptors, Thromboxane | 2015 |
Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging.
Topics: Acetylcholine; Aging; Animals; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Cyclic N-Oxides; Endothelium-Dependent Relaxing Factors; Fatty Acids, Unsaturated; Hydrazines; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Phenylephrine; Receptors, Thromboxane; RNA, Messenger; Spin Labels; Tissue Culture Techniques; Vasoconstrictor Agents; Vasodilator Agents | 2015 |
Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase.
Topics: Adamantane; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptides; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrazoles; Vascular Remodeling; Vasodilation | 2016 |
Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Arachidonic Acids; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cannabinoid Receptor Agonists; Cells, Cultured; Chromones; Cyclic AMP; Dose-Response Relationship, Drug; Endocannabinoids; Estrenes; Fatty Acids, Unsaturated; Glycerides; Humans; Hydrazines; Immunoblotting; Indoles; Intracellular Space; Maleimides; Milrinone; Morpholines; Phosphatidylinositol 3-Kinases; Phosphodiesterase 3 Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Protein Kinase C; Pyrrolidinones; Receptors, Thromboxane; Type C Phospholipases | 2016 |
Thromboxane A2 Receptor Inhibition Suppresses Multiple Myeloma Cell Proliferation by Inducing p38/c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase (MAPK)-mediated G2/M Progression Delay and Cell Apoptosis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Bridged Bicyclo Compounds, Heterocyclic; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cyclin B1; Cyclin-Dependent Kinases; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Hydrazines; Leukocytes, Mononuclear; MAP Kinase Signaling System; Multiple Myeloma; Neoplasm Proteins; Receptors, Thromboxane A2, Prostaglandin H2; RNA Interference | 2016 |
Menthol Modulates Pacemaker Potentials through TRPA1 Channels in Cultured Interstitial Cells of Cajal from Murine Small Intestine.
Topics: Acetanilides; Amides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Fatty Acids, Unsaturated; Gastrointestinal Motility; Hydrazines; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Menthol; Mice; Mice, Inbred BALB C; Oximes; Patch-Clamp Techniques; Purines; Pyrazoles; Pyridines; rho-Associated Kinases; Thromboxanes; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2016 |
Contribution of Cyclooxygenase End Products and Oxidative Stress to Intrahepatic Endothelial Dysfunction in Early Non-Alcoholic Fatty Liver Disease.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclic N-Oxides; Dietary Fats; Endothelium; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Male; Nitric Oxide; Nitroarginine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Labels; Splanchnic Circulation; Thromboxane B2 | 2016 |
Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophages activation and enrichment, and ameliorates brain injury.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytokines; Disease Models, Animal; Fatty Acids, Unsaturated; Gliosis; Hydrazines; Macrophage Activation; Mice, Inbred ICR; Receptors, Thromboxane A2, Prostaglandin H2; Reperfusion Injury; Stroke; Treatment Outcome | 2016 |
Role of ADP ribosylation factor6- Cytohesin1-PhospholipaseD signaling axis in U46619 induced activation of NADPH oxidase in pulmonary artery smooth muscle cell membrane.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetophenones; ADP Ribose Transferases; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Antioxidants; Botulinum Toxins; Brefeldin A; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Gene Expression Regulation; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrazines; Myocytes, Smooth Muscle; NADPH Oxidases; Phospholipase D; Primary Cell Culture; Protein Synthesis Inhibitors; Pulmonary Artery; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Triazoles; Vasoconstrictor Agents | 2017 |
Antagonist of thromboxane A2 receptor by SQ29548 lowers DOCA-induced hypertension in diabetic rats.
Topics: Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone Acetate; Diabetes Mellitus, Experimental; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Male; Nitric Oxide Synthase Type III; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2 | 2017 |
Sildenafil (Viagra®) Prevents Cox-1/ TXA2 Pathway-Mediated Vascular Hypercontractility in ApoE-/- Mice.
Topics: Animals; Apolipoproteins E; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Interleukin-10; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Phenylephrine; Pyrazoles; Receptors, Thromboxane; Sildenafil Citrate; Sulfonamides; Thromboxane A2; Vasoconstriction | 2017 |
Thromboxane A2 receptor antagonist SQ29548 attenuates SH‑SY5Y neuroblastoma cell impairments induced by oxidative stress.
Topics: Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Caspases; Catalase; Cell Line, Tumor; Cell Survival; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Hydrazines; Hydrogen Peroxide; Intracellular Space; MAP Kinase Signaling System; Neuroblastoma; Oxidative Stress; Receptors, Thromboxane A2, Prostaglandin H2; Superoxide Dismutase | 2018 |
Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Glucosides; Glycogen Synthase Kinase 3 beta; Hydrazines; Luteolin; Phosphatidylinositol 3-Kinases; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Purinergic P2Y12; Receptors, Thromboxane A2, Prostaglandin H2; rhoA GTP-Binding Protein; Serotonin; Signal Transduction; Thromboxane A2; Tritium | 2018 |
Neuroprotective effects of thromboxane receptor antagonist SQ 29,548 after pilocarpine-induced status epilepticus in mice.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Fatty Acids, Unsaturated; Female; Glial Fibrillary Acidic Protein; Hippocampus; Hydrazines; Mice; Motor Activity; Neurons; Neuroprotective Agents; Pilocarpine; Proto-Oncogene Proteins c-fos; Receptors, Thromboxane; Status Epilepticus | 2020 |
A sex-specific, COX-derived/thromboxane receptor activator causes depolarization and vasoconstriction in male mice mesenteric resistance arteries.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Mice; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Obesity; Piperazines; Receptors, Thromboxane; Sex Characteristics; Thiazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 2020 |