Page last updated: 2024-09-05

hydrastine and berberine

hydrastine has been researched along with berberine in 17 studies

Compound Research Comparison

Studies
(hydrastine)
Trials
(hydrastine)
Recent Studies (post-2010)
(hydrastine)
Studies
(berberine)
Trials
(berberine)
Recent Studies (post-2010) (berberine)
580114,1061022,791

Protein Interaction Comparison

ProteinTaxonomyhydrastine (IC50)berberine (IC50)
AcetylcholinesteraseElectrophorus electricus (electric eel)0.7827
Lysine-specific histone demethylase 1AHomo sapiens (human)6.97
CholinesteraseHomo sapiens (human)1.09
AcetylcholinesteraseHomo sapiens (human)0.4
Aldo-keto reductase family 1 member C3Homo sapiens (human)4.99
Aldo-keto reductase family 1 member C2 Homo sapiens (human)6.71
CholinesteraseEquus caballus (horse)9.4
Cytochrome P450 1B1Homo sapiens (human)0.9747

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19903 (17.65)18.7374
1990's1 (5.88)18.2507
2000's7 (41.18)29.6817
2010's5 (29.41)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Moniot, JL; Shamma, M1
Baker, W; Gentry, EJ; Humble, D; Jampani, HB; Keshavarz-Shokri, A; Mitscher, LA; Morton, MD; Shawar, R; Telikepalli, H; Velde, DV1
Abdel-Haq, H; Cometa, MF; Leone, MG; Palmery, M; Saso, L; Silvestrini, B1
Abourashed, EA; Khan, IA1
Fitzloff, JF; Li, W1
MIRZA, R; ROBINSON, R1
Holzgrabe, U; Laug, S; Unger, M1
Joseph, M; Weber, HA1
Bilski, P; Chignell, CF; He, YY; Inbaraj, JJ; Kukielczak, BM; Sik, RH1
KEENAN, GL1
Gupta, PK; Gurley, B; Hendrickson, HP; Hubbard, M1
Douglas, JA; Follett, JM; Littler, RA; Parmenter, GA; Perry, NB; Sansom, CE1
Burns, JT; Cech, NB; Ettefagh, KA; Junio, HA; Kaatz, GW1
Brettell, T; Dawes, ML1
Gurley, BJ; Markowitz, JS; Munoz, J; Wang, X; Zhu, HJ1
Farjon, J; Giraudeau, P; Le, PM; Martineau, E; Milande, C1
Caesar, LK; Cech, NB; Kellogg, JJ; Khin, M1

Other Studies

17 other study(ies) available for hydrastine and berberine

ArticleYear
The conversion of berberine into (+/-)-alpha- and (+/-)-beta-hydrastine.
    Journal of the American Chemical Society, 1976, Oct-13, Volume: 98, Issue:21

    Topics: Benzylisoquinolines; Berberine; Berberine Alkaloids; Isoquinolines

1976
Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.
    Journal of natural products, 1998, Volume: 61, Issue:10

    Topics: Alkaloids; Antitubercular Agents; Benzylisoquinolines; Berberine; Biological Products; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Plant Roots; Plants, Medicinal; Quinic Acid

1998
Relaxant effects of Hydrastis canadensis L. and its major alkaloids on guinea pig isolated trachea.
    Pharmacology & toxicology, 2000, Volume: 87, Issue:5

    Topics: Alkaloids; Animals; Benzylisoquinolines; Berberine; Bronchodilator Agents; Complementary Therapies; Drug Synergism; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Plant Extracts; Plants, Medicinal; Trachea

2000
High-performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal.
    Journal of pharmaceutical sciences, 2001, Volume: 90, Issue:7

    Topics: Alkaloids; Benzylisoquinolines; Berberine; Chromatography, High Pressure Liquid; Dietary Supplements; Plants, Medicinal

2001
A validated high performance liquid chromatographic method for the analysis of Goldenseal.
    The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:3

    Topics: Alkaloids; Benzylisoquinolines; Berberine; Chromatography, High Pressure Liquid; Plant Preparations; Reproducibility of Results

2002
Conversion of hydrastine into berberine, and an instance of the asymmetrical quaternization of a tertiary base.
    Nature, 1950, Aug-12, Volume: 166, Issue:4215

    Topics: Benzylisoquinolines; Berberine; Biological Products; Humans; Hydrastis

1950
Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts.
    Electrophoresis, 2005, Volume: 26, Issue:12

    Topics: Alkaloids; Benzylisoquinolines; Berberine; Dietary Supplements; Electrophoresis, Capillary; Hydrastis; Plant Extracts; Quality Control; Reproducibility of Results; Sensitivity and Specificity

2005
[Extraction and HPLC analysis of alkaloids in goldenseal].
    Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2004, Volume: 20, Issue:2

    Topics: Benzylisoquinolines; Berberine; Chromatography, High Pressure Liquid; Hydrastis; Plant Roots

2004
Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine.
    Chemical research in toxicology, 2006, Volume: 19, Issue:6

    Topics: Alkaloids; Benzylisoquinolines; Berberine; Berberine Alkaloids; Cell Line; Cell Survival; Humans; Hydrastis; Molecular Structure; Oxygen; Photochemistry; Photosensitizing Agents; Spectrum Analysis; Tetrahydroisoquinolines

2006
Microscopic identity tests for hydrastis and its principal alkaloids, hydrastine and berberine.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1948, Volume: 37, Issue:1

    Topics: Alkaloids; Benzylisoquinolines; Berberine; Biological Products; Hydrastis

1948
Validation of a liquid chromatography-tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum.
    Journal of pharmaceutical and biomedical analysis, 2009, May-01, Volume: 49, Issue:4

    Topics: Benzylisoquinolines; Berberine; Calibration; Chromatography, High Pressure Liquid; Dietary Supplements; Humans; Indicators and Reagents; Quality Control; Reproducibility of Results; Solvents; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2009
Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis.
    Fitoterapia, 2010, Volume: 81, Issue:7

    Topics: Benzylisoquinolines; Berberine; Hydrastis; Plant Structures; Seasons

2010
Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition.
    Planta medica, 2011, Volume: 77, Issue:8

    Topics: Alkaloids; Anti-Bacterial Agents; Bacterial Proteins; Benzylisoquinolines; Berberine; Drug Synergism; Ethidium; Hydrastis; Multidrug Resistance-Associated Proteins; Plant Components, Aerial; Plant Extracts; Plant Roots; Staphylococcus aureus

2011
Analysis of goldenseal, Hydrastis canadensis L., and related alkaloids in urine using HPLC with UV detection.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jan-01, Volume: 880, Issue:1

    Topics: Benzylisoquinolines; Berberine; Chromatography, High Pressure Liquid; Humans; Hydrastis; Limit of Detection; Linear Models; Plant Extracts; Plant Roots; Reproducibility of Results; Spectrophotometry, Ultraviolet; Substance Abuse Detection

2012
An ex vivo approach to botanical-drug interactions: a proof of concept study.
    Journal of ethnopharmacology, 2015, Apr-02, Volume: 163

    Topics: Adult; Benzylisoquinolines; Berberine; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Female; Herb-Drug Interactions; Humans; Hydrastis; Male; Microsomes, Liver; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult

2015
Quantification of natural products in herbal supplements: A combined NMR approach applied on goldenseal.
    Journal of pharmaceutical and biomedical analysis, 2019, Feb-20, Volume: 165

    Topics: Alkaloids; Benzylisoquinolines; Berberine; Biological Products; Chromatography, High Pressure Liquid; Hydrastis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Extracts; Plant Roots; Reproducibility of Results

2019
Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches.
    The Yale journal of biology and medicine, 2020, Volume: 93, Issue:2

    Topics: Benzylisoquinolines; Berberine; Berberine Alkaloids; Drug Stability; Drug Storage; Humans; Hydrastis; Infections; Mass Spectrometry; Plant Preparations; Plant Roots; Principal Component Analysis

2020