hydralazine and spironolactone

hydralazine has been researched along with spironolactone in 64 studies

Research

Studies (64)

Timeframe	Studies, this research(%)	All Research%
pre-1990	39 (60.94)	18.7374
1990's	2 (3.13)	18.2507
2000's	13 (20.31)	29.6817
2010's	10 (15.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Michel, D	1
Oparil, S; Rick, JH	1
Kuchel, OG; Mahon, WA; McKenzie, JK; Ogilvie, RI	1
Andersson, O; Berglund, G; Hansson, L; Sannerstedt, R; Sievertsson, R; Wikstrand, J; Wilhelmsen, L	1
Moses, C	1
Riddiough, MA	1
Daniele, E; De Nardo, D	1
Ebel, H; Klaus, D; Lübke, H; Witzgall, H; Zehner, J	1
Grim, CE	1
Angelino, PF	2
Voudoukis, IJ	1
Bishop, SP; Smith, SH	1
Kincaid-Smith, P	1
Simpson, FO	1
Perrier, CV; Sitavanc, L	1
Rahn, KH	1
Biglieri, EG; Giebink, GS; Gotlin, RW; Katz, FH	1
Branche, G; Chiles, B; Garnier, C; Kilcoyne, MM; Soland, T; Thomson, GE; Williams, M	1
Kilcoyne, MM	1
Kim, KE; Onesti, G; Swartz, C	1
Finnerty, FA	2
Fishback, DB	1
Isdale, JM; Katz, S; Thomson, PD	1
Sova, J	1
Loggie, JM	1
Milliez, P; Safar, M	2
Storm-Mathisen, H	1
Lagrue, G; Milliez, P; Safar, M; Schlotterer, P	1
Pomerantz, HZ	1
Stevenson, JG; Umstead, GS	1
Moyer, JH	1
Rutishauser, W	1
Bombig, MT; Costa, A; Ferreira Filho, C; Ferreira, C; Luna Filho, B; Murad, N; Póvoa, R	1
King, SR; Smeda, J; Vasdev, S	1
Gould, PA; Kaye, DM	1
Neves, MF; Schiffrin, EL; Virdis, A	1
Neves, MF; Pu, Q; Schiffrin, EL; Touyz, RM; Virdis, A	1
MATHISEN, HS	1
HILDEN, T	1
MIZGALA, HF	1
LATTA, H; LITMAN, N; SMITH, FG	1
de Resende, MM; Gomes, Mda G; Leite, CM; Milanez, Mda C; Mill, JG	1
Endemann, DH; Iglarz, M; Savoia, C; Schiffrin, EL; Touyz, RM	1
Fiscella, K	1
Fujita, T; Gotoda, T; Nagase, M; Nagase, T; Shibata, S; Yoshida, S	1
Fujita, T; Kawachi, H; Nagase, M; Shibata, S; Yoshida, S	1
Amann, K; Hartner, A; Hilgers, KF; Klanke, B; Melk, A; Steinbach, MP; Westhoff, JH	1
Cordasic, N; Hartner, A; Hilgers, KF; Klanke, B; Schmieder, RE; Veelken, R	1
Cohn, JN; Ghali, JK; Lindenfeld, J; Sabolinski, ML; Tam, SW; Taylor, AL; Worcel, M	1
Grossman, E; Kamari, Y; Koren, F; Peleg, E; Sharabi, Y; Shimoni, N	1
Ando, K; Fujita, M; Fujita, T; Kawarazaki, H; Matsui, H; Nagae, A	1
Fan, YY; Felder, RA; Fujisawa, Y; Hitomi, H; Kitada, K; Kohno, M; Nakano, D; Nishiyama, A; Noma, T; Ohsaki, H; Rafiq, K; Sherajee, SJ; Yatabe, J; Yatabe, M	1
Black, HR; Slim, HB; Thompson, PD	1
Deguchi, K; Hitomi, H; Kitada, K; Kobori, H; Lei, B; Masaki, T; Minamino, T; Mori, H; Nakano, D; Nishiyama, A	1
Amann, K; Habib, SL; Hey, V; Queisser, N; Schupp, N	1
Dorrance, AM; Jackson, WF; Pires, PW	1
Gong, H; Li, H; Lu, Y; Ma, X; Wang, B; Wang, C; Wu, Z; Yan, Y; Zhang, X	1

Reviews

11 review(s) available for hydralazine and spironolactone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Management of high blood pressure using beta-sympatholytics. Review]. Fortschritte der Medizin, 1976, Nov-11, Volume: 94, Issue:32 Topics: Adrenergic beta-Antagonists; Clonidine; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Spironolactone	1976
Preventing, detecting and managing adverse reactions of antihypertensive agents in the ambulant patient with essential hypertension. American journal of hospital pharmacy, 1977, Volume: 34, Issue:5 Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Drug Interactions; Ethacrynic Acid; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Prazosin; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors; Spironolactone	1977
[Report on the incidence and pathogenetic problems of drug-induced gastroduodenal lesions]. La Clinica terapeutica, 1978, Apr-15, Volume: 85, Issue:1 Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Drug-Related Side Effects and Adverse Reactions; Estrogens; Gastrointestinal Diseases; Humans; Hydralazine; Hydroxybenzoates; Hypoglycemic Agents; Indoleacetic Acids; Nicotinic Acids; ortho-Aminobenzoates; Phenylacetates; Propionates; Pyrazoles; Reserpine; Rheumatic Diseases; Spironolactone	1978
Combination antihypertensive therapy. Cardiovascular clinics, 1971, Volume: 2, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amphetamine; Antidepressive Agents; Antihypertensive Agents; Benzothiadiazines; Clonidine; Debrisoquin; Diuretics; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Monoamine Oxidase Inhibitors; Phenylbutazone; Phytotherapy; Plants, Medicinal; Potassium Chloride; Rauwolfia; Reserpine; Secologanin Tryptamine Alkaloids; Sodium Chloride Symporter Inhibitors; Spironolactone; Sympathomimetics; Triamterene	1971
[Current antihypertensive drugs: mechanism of action]. Schweizerische medizinische Wochenschrift, 1973, Nov-24, Volume: 103, Issue:47 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Catecholamines; Central Nervous System; Clonidine; Diazoxide; Diuretics; Drug Synergism; Guanethidine; Guanidines; Humans; Hydralazine; Methyldopa; Propranolol; Reserpine; Spironolactone	1973
Hypertension in children and adolescents. II. Drug therapy. The Journal of pediatrics, 1969, Volume: 74, Issue:4 Topics: Age Factors; Antihypertensive Agents; Blood Pressure Determination; Child; Chlorothiazide; Chronic Disease; Diazoxide; Female; Ferricyanides; Glomerulonephritis; Guanethidine; Humans; Hydralazine; Hypertension; Hypotension, Orthostatic; Methyldopa; Phenoxybenzamine; Phentolamine; Reserpine; Spironolactone	1969
Drug systems approach to hypertension. Pennsylvania medicine, 1984, Volume: 87, Issue:5 Topics: Captopril; Clonidine; Drug Combinations; Drug Therapy, Combination; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Hypertension, Malignant; Methyldopa; Patient Compliance; Prazosin; Proteinuria; Renin-Angiotensin System; Reserpine; Spironolactone	1984
Clinical treatment regimens for chronic heart failure: a review. Expert opinion on pharmacotherapy, 2002, Volume: 3, Issue:11 Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiotonic Agents; Digoxin; Diuretics; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Pacemaker, Artificial; Spironolactone; Vasodilator Agents	2002
NEWER DRUGS IN THE TREATMENT OF HYPERTENSION. Canadian Medical Association journal, 1965, Apr-24, Volume: 92 Topics: Antihypertensive Agents; Bretylium Compounds; Chlorothiazide; Chlorthalidone; Diuretics; Drug Therapy; Essential Hypertension; Guanethidine; Hydralazine; Hypertension; Methyldopa; Pargyline; Rauwolfia; Spironolactone; Toxicology	1965
Older blood pressure medications-do they still have a place? The American journal of cardiology, 2011, Jul-15, Volume: 108, Issue:2 Topics: Antihypertensive Agents; Chlorthalidone; Clonidine; Diuretics; Ethacrynic Acid; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Reserpine; Spironolactone; Vasodilator Agents	2011

Trials

1 trial(s) available for hydralazine and spironolactone

Article	Year
[Treatment of essential hypertension with a combination of propranolol, spironolactone-thiabutazide and dihydralazine (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1978, Oct-20, Volume: 103, Issue:42 Topics: Anxiety; Bradycardia; Dihydralazine; Drug Therapy, Combination; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Paresthesia; Potassium; Propranolol; Renin; Spironolactone	1978

Article

Year

[Treatment of essential hypertension with a combination of propranolol, spironolactone-thiabutazide and dihydralazine (author's transl)].

Deutsche medizinische Wochenschrift (1946), 1978, Oct-20, Volume: 103, Issue:42

Topics: Anxiety; Bradycardia; Dihydralazine; Drug Therapy, Combination; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Paresthesia; Potassium; Propranolol; Renin; Spironolactone

1978

Other Studies

52 other study(ies) available for hydralazine and spironolactone

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Drug treatment of hypertension. Comprehensive therapy, 1977, Volume: 3, Issue:5 Topics: Clonidine; Diazoxide; Diuretics; Ganglionic Blockers; Guanethidine; Humans; Hydralazine; Hypertension; Mecamylamine; Methyldopa; Mineralocorticoid Receptor Antagonists; Minoxidil; Nitroprusside; Prazosin; Propranolol; Secologanin Tryptamine Alkaloids; Sodium Chloride Symporter Inhibitors; Spironolactone; Sympatholytics; Triamterene; Trimethaphan; Vasodilator Agents	1977
Approach to drug therapy for hypertension. Canadian Medical Association journal, 1979, Mar-03, Volume: 120, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Guanidines; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Patient Care Planning; Patient Compliance; Prazosin; Reserpine; Sodium Chloride Symporter Inhibitors; Spironolactone; Vasodilator Agents	1979
Effect of treatment of hypertension in the primary preventive trial, Göteborg, Sweden. British journal of clinical pharmacology, 1979, Volume: 7 Suppl 2 Topics: Adrenergic beta-Antagonists; Bethanidine; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease; Diuretics; Drug Evaluation; Furosemide; Humans; Hydralazine; Hypertension; Male; Middle Aged; Myocardial Infarction; Spironolactone; Sweden	1979
Drug treatment of mild hypertension: adverse consequences. Annals of the New York Academy of Sciences, 1978, Mar-30, Volume: 304 Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Drug Interactions; Female; Guanethidine; Humans; Hydralazine; Hypertension; Male; Methyldopa; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors; Spironolactone	1978
Office management of hypertension. American family physician, 1976, Volume: 14, Issue:1 Topics: Antihypertensive Agents; Diuretics; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Physical Examination; Physicians, Family; Potassium; Propranolol; Spironolactone; Triamterene	1976
[Therapeutic combinations, side effects and interactions of antihypertensive drugs]. Minerva cardioangiologica, 1976, Volume: 24, Issue:6 Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Dihydralazine; Diuretics; Drug Interactions; Drug Therapy, Combination; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Propranolol; Reserpine; Spironolactone	1976
[Drug combinations in the treatment of primary arterial hypertension]. Minerva medica, 1975, Feb-21, Volume: 66, Issue:13 Topics: Antihypertensive Agents; Blood Volume; Cardiac Output; Diuretics; Drug Combinations; Drug Therapy, Combination; Guanethidine; Heart; Humans; Hydralazine; Hypertension; Methyldopa; Propranolol; Renin; Reserpine; Spironolactone; Vascular Resistance	1975
Prognostic and therapeutic considerations in pure hypertension vs hypertension and superimposed arteriosclerosis. Angiology, 1975, Volume: 26, Issue:1 Pt. 1 Topics: Arteriosclerosis; Blood Pressure; Cold Temperature; Digitalis; Female; Follow-Up Studies; Humans; Hydralazine; Hypertension; Male; Plants, Medicinal; Plants, Toxic; Private Practice; Prognosis; Reserpine; Sex Factors; Spironolactone; Statistics as Topic	1975
Selection criteria for drug-treated animals in two-kidney, one clip renal hypertension. Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:8 Topics: Animals; Atrophy; Constriction; Hydralazine; Hypertension, Renal; Kidney; Male; Organ Size; Rats; Rats, Inbred Strains; Spironolactone	1986
Management of severe hypertension. The American journal of cardiology, 1973, Sep-20, Volume: 32, Issue:4 Topics: Benzothiadiazines; Blood Pressure; Clonidine; Diazoxide; Diet, Sodium-Restricted; Disseminated Intravascular Coagulation; Ethanolamines; Female; Glomerular Filtration Rate; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Pre-Eclampsia; Pregnancy; Propranolol; Renin; Sodium; Spironolactone	1973
[Differential therapeutic principles in the drug therapy of high blood pressure]. Der Internist, 1974, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Cardiac Volume; Clonidine; Diuretics; Drug Combinations; Guanethidine; Humans; Hydralazine; Hypertension; Kidney Failure, Chronic; Methyldopa; Renin; Reserpine; Sodium Chloride Symporter Inhibitors; Spironolactone; Time Factors; Triamterene	1974
A kindred with familial glucocorticoid suppressible aldosteronism. The Journal of clinical endocrinology and metabolism, 1973, Volume: 36, Issue:4 Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aldosterone; Binding, Competitive; Child; Dexamethasone; Female; Fluorometry; Humans; Hydralazine; Hydrocortisone; Hyperaldosteronism; Male; Methyldopa; Pregnanetriol; Radioimmunoassay; Renin; Spironolactone; Tetrahydrocortisone	1973
Characteristics of hypertension in the black population. Circulation, 1974, Volume: 50, Issue:5 Topics: Adult; Angiotensin II; Animals; Black or African American; Cardiomegaly; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Drug Therapy, Combination; Female; Guanethidine; Heart Ventricles; Humans; Hydralazine; Hypertension; Male; Methyldopa; Middle Aged; New York City; Rabbits; Radioimmunoassay; Renin; Sodium; Spironolactone	1974
Adolescent hypertension. II. Characteristics and response to treatment. Circulation, 1974, Volume: 50, Issue:5 Topics: Adolescent; Adult; Angiotensin II; Black or African American; Female; Humans; Hydralazine; Hypertension; Kidney; Latin America; Male; Mass Screening; Methyldopa; New York City; Propranolol; Radioimmunoassay; Renin; Sodium; Spironolactone	1974
Problems in therapy for the hypertensive patient. Geriatrics, 1973, Volume: 28, Issue:3 Topics: Antihypertensive Agents; Blood Pressure; Carotid Sinus; Diuretics; Electric Stimulation; Ethacrynic Acid; Female; Furosemide; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Hypertension, Malignant; Hypertension, Renal; Hypotension, Orthostatic; Male; Methyldopa; Nephrectomy; Phytotherapy; Plants, Medicinal; Posture; Rauwolfia; Spironolactone; Uremia	1973
How to treat arterial hypertension. American family physician, 1973, Volume: 7, Issue:4 Topics: Antihypertensive Agents; Chlorothiazide; Chlorthalidone; Cooperative Behavior; Diazoxide; Diuretics; Ethacrynic Acid; Furosemide; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney; Methyldopa; Physician-Patient Relations; Reserpine; Spironolactone; Sulfonamides; Triamterene	1973
Fluorescein circulation time and the treatment of hypertension in the aged. Journal of the American Geriatrics Society, 1973, Volume: 21, Issue:11 Topics: Adult; Age Factors; Aged; Blood Circulation Time; Blood Pressure; Carbamates; Ethacrynic Acid; Female; Fluoresceins; Furosemide; Glomerular Filtration Rate; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney Failure, Chronic; Male; Methyldopa; Middle Aged; Potassium; Reserpine; Spironolactone	1973
Infantile polycystic disease of the kidneys. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Oct-13, Volume: 47, Issue:40 Topics: Child, Preschool; Chlorothiazide; Female; Guanethidine; Humans; Hydralazine; Hypertension, Renal; Infant; Infant, Newborn; Kidney; Liver; Liver Cirrhosis; Male; Methyldopa; Polycystic Kidney Diseases; Propranolol; Spironolactone; Urography	1973
Drugs used in the treatment of hypertension. Modern concepts of cardiovascular disease, 1973, Volume: 42, Issue:7 Topics: Administration, Oral; Antihypertensive Agents; Clonidine; Diazoxide; Diuretics; Ethacrynic Acid; Ferricyanides; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Nitric Oxide; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors; Spironolactone; Triamterene; Vasodilator Agents	1973
[New trends in the diagnosis, prognosis and treatment of hypertension]. Vnitrni lekarstvi, 1974, Volume: 20, Issue:3 Topics: Dexamethasone; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Prognosis; Propranolol; Reserpine; Spironolactone	1974
[Hemodynamic basis of the medical treatment of arterial hypertension]. Bulletin de l'Academie nationale de medecine, 1971, Jan-19, Volume: 155, Issue:3 Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Output; Diuretics; Female; Guanethidine; Hemodynamics; Humans; Hydralazine; Hypertension; Male; Methyldopa; Spironolactone	1971
[Antihypertensive therapy]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1972, Jul-10, Volume: 92, Issue:19 Topics: Adult; Antihypertensive Agents; Clonidine; Diuretics; Drug Interactions; Female; Humans; Hydralazine; Hypertension; Male; Methyldopa; Middle Aged; Phytotherapy; Plants, Medicinal; Rauwolfia; Spironolactone; Sympatholytics	1972
[Medical treatment of arterial hypertension. Clinical study]. La Presse medicale, 1971, Feb-13, Volume: 79, Issue:8 Topics: Adult; Antihypertensive Agents; Diuretics; Female; Guanethidine; Humans; Hydralazine; Hypertension; Male; Methyldopa; Middle Aged; Prognosis; Spironolactone	1971
[Medical treatment of arterial hypertension: hemodynamic study]. Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1971, Volume: 16, Issue:4 Topics: Adult; Antihypertensive Agents; Cardiac Output; Chlorothiazide; Diuretics; Female; Hemodynamics; Humans; Hydralazine; Hypertension; Male; Methyldopa; Spironolactone	1971
Hypotensive drug therapy in the management of hypertension. American heart journal, 1969, Volume: 78, Issue:4 Topics: Antihypertensive Agents; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Methyldopa; Pargyline; Reserpine; Spironolactone	1969
Sexual dysfunction due to antihypertensive agents. Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:2 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Female; Guanethidine; Humans; Hydralazine; Male; Methyldopa; Prazosin; Propranolol; Reserpine; Sex; Sexual Dysfunction, Physiological; Sodium Chloride Symporter Inhibitors; Spironolactone	1984
A review of the long-term effects of prazosin and hydralazine in chronic congestive heart failure. European heart journal, 1983, Volume: 4 Suppl A Topics: Chronic Disease; Drug Therapy, Combination; Follow-Up Studies; Heart Failure; Humans; Hydralazine; Nitrates; Prazosin; Quinazolines; Spironolactone; Time Factors	1983
[Spironolactone protection from hydralazine-induced stress in the rat myocardium]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 1998, Volume: 17, Issue:9 Topics: Adrenal Glands; Animals; Antihypertensive Agents; Drug Evaluation, Preclinical; Heart; Hydralazine; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Wistar; Spironolactone; Stress, Physiological	1998
Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Aldosterone; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Captopril; Cerebral Hemorrhage; Dexamethasone; Drug Interactions; Hydralazine; Hypertension; Male; Rats; Rats, Inbred SHR; Spironolactone; Stroke; Survival Rate; Time Factors	1999
Resistance artery mechanics and composition in angiotensin II-infused rats: effects of aldosterone antagonism. Journal of hypertension, 2003, Volume: 21, Issue:1 Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Collagen; Hydralazine; Male; Mesenteric Arteries; Microscopy, Confocal; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Renin; Spironolactone; Vascular Resistance; Vasodilator Agents	2003
Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:1 Topics: Aldosterone; Animals; Blood Pressure; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Matrix; Heart; Hydralazine; Intercellular Adhesion Molecule-1; Male; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Spironolactone; Thiobarbituric Acid Reactive Substances; Vasodilator Agents	2003
[DRUG THERAPY OF HIGH BLOOD PRESSURE IN THE PAST, PRESENT AND FUTURE]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1963, Nov-15, Volume: 83 Topics: Antihypertensive Agents; Chlorothiazide; Chlorthalidone; Guanethidine; Humans; Hydralazine; Hypertension; Mecamylamine; Monoamine Oxidase Inhibitors; Pentolinium Tartrate; Pharmacology; Rauwolfia; Spironolactone; Veratrum	1963
[MEDICAL TREATMENT OF HYPERTENSION]. Ugeskrift for laeger, 1964, Apr-23, Volume: 126 Topics: Antihypertensive Agents; Bretylium Compounds; Diuretics; Ganglionic Blockers; Guanethidine; Hydralazine; Hypertension; Methyldopa; Rauwolfia; Spironolactone	1964
LUPUS GLOMERULONEPHRITIS. THE EFFECT OF LARGE DOSES OF CORTICOSTEROIDS ON RENAL FUNCTION AND RENAL LESIONS IN TWO CHILDREN. American journal of diseases of children (1960), 1965, Volume: 110 Topics: Adolescent; Adrenal Cortex Hormones; Cortisone; Drug Therapy; Glomerulonephritis; Guanethidine; Hydralazine; Hydrochlorothiazide; Kidney Function Tests; Lupus Erythematosus, Systemic; Lupus Nephritis; Methantheline; Pathology; Prednisone; Propantheline; Quaternary Ammonium Compounds; Reserpine; Spironolactone; Triamcinolone	1965
Spironolactone prevents cardiac collagen proliferation after myocardial infarction in rats. Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:10 Topics: Animals; Cicatrix; Collagen; Hydralazine; Losartan; Male; Myocardial Infarction; Myocardium; Organ Size; Rats; Rats, Wistar; Spironolactone	2003
Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:6 Topics: Acetylcholine; Aldosterone; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Collagen; Dose-Response Relationship, Drug; Endothelium, Vascular; Eplerenone; Fibrosis; Heart; Hydralazine; Hypertension; Male; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; Myocardium; Natriuresis; Organ Size; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone; Thiobarbituric Acid Reactive Substances; Tunica Media; Vasodilation	2004
Update on outpatient treatment of systolic heart failure. American family physician, 2005, Oct-01, Volume: 72, Issue:7 Topics: Ambulatory Care; Black or African American; Diuretics; Drug Therapy, Combination; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Spironolactone; Treatment Outcome; Vasodilator Agents	2005
Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension (Dallas, Tex. : 1979), 2006, Volume: 47, Issue:6 Topics: Animals; Apoptosis; Biomarkers; Blood Pressure; Eplerenone; Fibrosis; Glomerulosclerosis, Focal Segmental; Hydralazine; Hypertension; Kidney; Male; Microscopy, Electron; Mineralocorticoid Receptor Antagonists; Nephritis; Oxidative Stress; Podocytes; Proteinuria; Rats; Rats, Inbred Dahl; Spironolactone; Time Factors	2006
Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:2 Topics: Aldosterone; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Cells, Cultured; Cyclic N-Oxides; Enzyme Activation; Eplerenone; Hydralazine; Immediate-Early Proteins; Infusion Pumps; Kidney; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Nephrectomy; Oxidative Stress; Podocytes; Protein Serine-Threonine Kinases; Proteinuria; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Spin Labels; Spironolactone; Time Factors; Up-Regulation	2007
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:1 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Desoxycorticosterone; Heart Ventricles; Humans; Hydralazine; Hydrochlorothiazide; Hypertension, Renal; Kidney; Losartan; Mice; Mineralocorticoid Receptor Antagonists; Nephrosclerosis; p38 Mitogen-Activated Protein Kinases; Rats; Renin; Reserpine; RNA, Messenger; Spironolactone	2008
Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:11 Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Disease Progression; Diuretics; Dose-Response Relationship, Drug; Glomerulonephritis; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Nephrosclerosis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reserpine; Spironolactone	2008
Exploring the potential synergistic action of spironolactone on nitric oxide-enhancing therapy: insights from the African-American Heart Failure Trial. Journal of cardiac failure, 2008, Volume: 14, Issue:9 Topics: Adult; Aged; Black or African American; Clinical Trials, Phase III as Topic; Drug Combinations; Drug Synergism; Female; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Male; Middle Aged; Multicenter Studies as Topic; Nitric Oxide Donors; Randomized Controlled Trials as Topic; Retrospective Studies; Spironolactone	2008
High-salt diet increases plasma adiponectin levels independent of blood pressure in hypertensive rats: the role of the renin-angiotensin-aldosterone system. Journal of hypertension, 2010, Volume: 28, Issue:1 Topics: Adiponectin; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Clonidine; Eplerenone; Hydralazine; Hypertension; Male; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium Chloride, Dietary; Spironolactone; Telmisartan	2010
Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:9 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Cyclic N-Oxides; Deoxyguanosine; Eplerenone; Hydralazine; Hypertension; Kidney; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Dahl; Receptors, Mineralocorticoid; Renal Insufficiency; Sodium Chloride, Dietary; Spin Labels; Spironolactone	2010
Aldosterone/Mineralocorticoid receptor stimulation induces cellular senescence in the kidney. Endocrinology, 2011, Volume: 152, Issue:2 Topics: Acetylglucosaminidase; Aldosterone; Animals; Blood Pressure; Blotting, Western; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Eplerenone; Humans; Hydralazine; Hypertension; Kidney; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sirtuin 1; Spironolactone; Tumor Suppressor Protein p53	2011
Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice. American journal of hypertension, 2012, Volume: 25, Issue:3 Topics: Actins; Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cellular Senescence; Eplerenone; Genes, p16; Genes, p53; Hydralazine; Hypertension; Imidazoles; Kidney; Mice; Mice, Inbred C57BL; p21-Activated Kinases; Sirtuin 1; Sodium Chloride; Spironolactone; Tetrazoles	2012
Blood pressure has only minor influence on aldosterone-induced oxidative stress and DNA damage in vivo. Free radical biology & medicine, 2013, Volume: 54 Topics: Aldosterone; Animals; Apoptosis; Blood Pressure; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic N-Oxides; DNA Damage; Hydralazine; Hypertension; Kidney; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Mineralocorticoid; Spin Labels; Spironolactone	2013
Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. American journal of physiology. Heart and circulatory physiology, 2015, Jul-01, Volume: 309, Issue:1 Topics: Animals; Antihypertensive Agents; Arterioles; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebrovascular Circulation; Cerebrum; Compliance; Eplerenone; Hydralazine; Hydrochlorothiazide; Hypertension; Middle Cerebral Artery; Mineralocorticoid Receptor Antagonists; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Mineralocorticoid; Reserpine; Spironolactone; Vascular Remodeling; Vascular Stiffness	2015
Mineralocorticoid receptor antagonism protects the aorta from vascular smooth muscle cell proliferation and collagen deposition in a rat model of adrenal aldosterone-producing adenoma. Journal of physiology and biochemistry, 2018, Volume: 74, Issue:1 Topics: ACTH-Secreting Pituitary Adenoma; Aldosterone; Animals; Antihypertensive Agents; Aorta; Cell Proliferation; Collagen; Disease Models, Animal; Eplerenone; Hydralazine; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-mdm2; Random Allocation; Rats, Sprague-Dawley; Spironolactone; Transforming Growth Factor beta; Vascular Remodeling; Vasodilator Agents	2018